Hub : Genes

Prodh2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr1_85764788_85764858 0.02 0.02 9.3e-03 0.02 0.02 0.02 0.02 3.6e-03 1.0e-02 5.1e-03 1.0e-02
2 Adipose gene expression Prodh2 0.06 0.04 3.9e-06 0.04 0.03 0.03 0.03 4.9e-05 2.1e-04 4.1e-04 2.0e-04
3 Liver isoform ratio XR_005487884.1 0.07 0.05 3.8e-06 0.03 0.04 0.03 0.03 8.0e-04 7.1e-05 6.0e-04 2.8e-04
4 PL intron excision ratio chr1_85764788_85764858 0.09 0.06 5.5e-03 0.02 0.01 0 0.02 3.3e-03 7.0e-02 8.9e-02 5.3e-03
5 PL gene expression Prodh2 0.07 0.05 7.5e-04 0.04 0.02 0.01 0.02 9.9e-05 9.3e-04 2.0e-02 1.0e-03
6 Brain gene expression Prodh2 0.08 0.05 2.3e-04 0.04 0.04 0.03 0.04 5.8e-05 2.0e-04 6.6e-04 4.4e-05
7 Liver intron excision ratio chr1_85754328_85754415 0.68 0.09 0.0e+00 0.49 0.5 0.5 0.5 4.4e-61 7.5e-63 1.8e-64 5.4e-63
8 Liver intron excision ratio chr1_85754098_85754190 0.37 0.13 0.0e+00 0.18 0.19 0.19 0.19 1.1e-19 5.7e-21 2.0e-20 5.2e-21
9 Liver intron excision ratio chr1_85754298_85754415 0.65 0.09 0.0e+00 0.48 0.49 0.5 0.49 1.8e-59 2.7e-61 6.4e-63 2.8e-61
10 Liver gene expression Prodh2 0.48 0.12 0.0e+00 0.18 0.31 0.31 0.31 3.7e-20 3.7e-35 6.1e-35 8.3e-35
11 Liver isoform ratio XM_039081896.1 0.31 0.13 0.0e+00 0.16 0.18 0.17 0.18 9.3e-18 1.2e-19 9.2e-19 4.5e-19
12 Liver mRNA stability Prodh2 0.49 0.13 0.0e+00 0.31 0.33 0.32 0.32 2.3e-35 4.0e-37 3.6e-36 2.3e-36
13 Liver isoform ratio NM_001038588.1 0.51 0.17 0.0e+00 0.26 0.27 0.26 0.26 9.0e-29 1.7e-30 2.3e-28 2.6e-29
14 Liver intron excision ratio chr1_85763435_85764858 0.56 0.12 0.0e+00 0.33 0.35 0.35 0.35 2.0e-37 2.0e-40 9.0e-41 9.0e-40
15 Liver intron excision ratio chr1_85763435_85764816 0.41 0.14 0.0e+00 0.23 0.22 0.23 0.22 1.1e-24 1.2e-24 8.6e-25 2.1e-24

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.01.72.8-1.1-1.1-1.4-1.70.4-1.5-1.61.61.6-1.1-1.41.41.2-0.91.2
Area under the delay curve0.90.92.0-0.5-0.10.20.9-1.10.71.0-1.1-1.01.21.0-1.0-0.71.4-1.3
BMI with tail0.20.71.20.60.91.10.90.21.01.0-0.7-1.00.60.8-1.0-1.00.8-0.8
BMI without tail0.10.10.5-0.7-0.1-0.3-0.20.4-0.2-0.20.30.2-0.3-0.40.30.5-0.20.3
Body weight1.25.012.3-3.5-3.4-3.2-2.9-1.4-2.3-2.22.12.1-0.4-1.91.91.80.00.7
Weight adjusted by age0.10.10.60.3-0.7-0.2-0.5-0.2-0.8-0.30.40.3-0.1-0.10.2-0.30.10.1
Bone surface0.50.83.2-1.8-1.6-1.4-1.0-1.2-0.6-0.70.60.70.3-0.40.50.40.4-0.1
Bone volume0.71.12.8-1.6-1.7-1.6-1.4-0.9-1.0-1.11.01.1-0.1-0.80.90.70.10.3
Breakpoint value in progressive ratio session0.80.92.4-1.6-0.7-0.50.6-1.20.30.8-1.0-0.91.20.5-0.70.11.4-1.2
Number of licking bursts3.23.76.02.21.62.32.2-0.22.02.1-2.0-2.11.52.2-2.1-2.51.2-1.6
Context. condit. distance diff. score0.91.11.60.1-0.00.70.9-1.11.21.1-1.1-1.11.31.2-1.1-1.21.2-1.2
Locomotion velocity, session 10.60.71.30.90.50.1-0.61.2-0.9-0.70.80.7-1.1-0.80.70.6-1.11.1
Locomotion distance, session 10.40.51.5-0.9-1.0-0.40.1-1.20.30.3-0.4-0.40.90.4-0.4-0.41.0-0.8
Locomotion velocity, session 20.20.21.20.61.10.40.30.80.20.1-0.1-0.1-0.4-0.1-0.00.3-0.40.4
Locomotion distance, session 21.72.43.31.21.51.71.7-0.31.51.7-1.6-1.71.31.7-1.8-1.71.5-1.5
Locomotion velocity, session 30.10.10.70.70.90.40.30.20.30.3-0.2-0.30.10.3-0.3-0.50.1-0.1
Locomotion distance, session 32.22.46.3-1.7-1.2-0.60.7-2.51.31.2-1.2-1.22.21.3-1.2-1.02.4-2.0
Stereotopy head waving bouts, day 31.82.15.40.70.9-0.1-0.92.3-1.2-1.21.41.2-2.0-1.51.31.4-2.01.8
Stereotopy head waving duration, day 31.72.06.51.21.40.4-0.62.6-1.1-1.01.21.0-2.0-1.31.11.2-1.91.7
Locomotion velocity, session 70.70.71.7-0.8-0.6-0.00.4-1.30.80.7-0.7-0.71.20.8-0.8-0.81.3-1.1
Locomotion distance, session 70.10.10.4-0.4-0.5-0.4-0.3-0.6-0.1-0.20.10.20.30.00.0-0.20.3-0.1
Stereotopy head waving bouts, day 71.31.52.51.11.01.31.5-0.11.61.3-1.4-1.31.01.3-1.3-1.30.8-1.1
Stereotopy head waving duration, day 71.01.32.91.71.71.71.40.81.21.1-1.0-1.10.30.9-1.1-1.00.2-0.6
Locomotion velocity, session 82.83.45.82.02.22.42.30.12.02.0-2.0-1.91.21.9-2.0-2.00.9-1.3
Locomotion distance, session 82.74.05.80.91.01.72.1-1.32.12.2-2.3-2.22.22.3-2.3-2.42.1-2.1
Degree of sensitization distance1.21.22.90.60.2-0.1-0.81.2-1.2-1.11.11.2-1.4-1.11.00.8-1.71.5
Degree of sensitization stereotypy2.42.64.01.21.11.61.9-0.52.01.7-1.9-1.71.51.8-1.8-1.81.2-1.5
Conditioned locomotion0.60.71.20.90.81.01.10.20.91.0-0.9-1.00.50.7-0.9-0.60.6-0.6
Cocaine response after cond. corrected1.41.52.80.20.4-0.4-1.11.5-1.2-1.31.41.3-1.7-1.31.31.3-1.61.5
Cocaine response after cond. not corrected3.03.35.40.00.4-0.9-1.72.0-1.8-1.92.01.9-2.3-2.02.02.0-2.32.2
Cocaine response before conditioning0.91.02.5-1.3-1.0-1.6-1.2-0.5-1.0-1.10.91.1-0.5-0.91.11.1-0.70.8
Saline control response0.30.40.6-0.20.0-0.4-0.70.5-0.7-0.60.70.6-0.7-0.80.60.8-0.60.7
Bone: connectivity density0.20.30.7-0.8-0.4-0.8-0.70.2-0.5-0.70.70.7-0.4-0.60.70.6-0.30.5
Bone: cortical apparent density1.11.53.61.91.51.71.30.31.11.2-1.1-1.20.61.2-1.3-1.40.7-0.8
Bone: cortical area0.81.12.2-1.4-1.3-1.5-1.3-0.6-1.3-1.21.01.1-0.5-1.01.11.0-0.30.7
Bone: cortical porosity2.52.84.51.11.51.62.1-0.22.02.0-2.0-2.01.41.9-1.8-1.71.2-1.5
Bone: cortical porosity3.43.75.51.31.61.92.3-0.42.32.3-2.3-2.21.62.2-2.1-2.01.4-1.7
Bone: cortical thickness0.50.91.4-0.5-0.5-1.0-1.20.3-1.2-1.11.11.1-0.9-1.11.11.0-0.70.9
Bone: cortical thickness0.30.41.20.90.80.4-0.11.1-0.5-0.30.40.3-0.9-0.50.30.3-0.70.7
Bone: cortical tissue density1.41.84.12.01.71.91.50.31.21.3-1.2-1.30.71.3-1.4-1.50.8-0.9
Condit. Reinf. active minus inactive responses0.10.20.50.60.70.50.60.30.10.3-0.3-0.30.10.3-0.4-0.30.3-0.2
Condit. Reinf. active-inactive response ratio0.60.61.90.40.70.1-0.41.4-1.0-0.60.80.6-1.2-0.80.70.8-0.80.9
Condit. Reinf. active responses1.62.03.51.71.91.91.70.41.31.5-1.4-1.50.71.3-1.5-1.31.0-1.1
Condit. Reinf. inactive responses3.44.15.91.71.82.22.2-0.62.42.3-2.2-2.31.72.1-2.3-2.11.8-1.9
Incentive salience index mean0.30.40.70.40.80.70.90.10.50.7-0.6-0.70.40.6-0.7-0.50.7-0.6
Condit. Reinf. lever presses0.40.61.0-0.20.40.40.9-0.50.80.9-0.9-0.90.80.8-0.8-0.51.0-0.9
Condit. Reinf. active minus inactive responses0.40.52.6-1.6-0.6-1.3-0.7-0.6-0.3-0.60.50.6-0.1-0.60.61.00.10.2
Condit. Reinf. active-inactive response ratio0.00.00.30.20.50.1-0.00.10.1-0.00.10.0-0.2-0.10.0-0.0-0.10.1
Condit. Reinf. active responses0.91.36.5-2.6-1.6-1.9-0.9-1.4-0.4-0.70.50.60.4-0.50.71.00.4-0.1
Condit. Reinf. inactive responses1.21.57.1-2.7-2.0-1.7-0.2-2.00.20.0-0.3-0.11.30.30.00.31.1-0.9
Condit. Reinf. lever presses2.83.811.7-3.4-2.7-3.1-2.2-1.3-1.5-1.81.61.7-0.4-1.61.82.0-0.20.7
Condit. Reinf. lever reinforcers received0.91.36.5-2.6-1.8-1.8-0.7-1.8-0.1-0.40.20.40.8-0.20.40.60.7-0.4
Conditioned reinforcement - actives0.00.00.30.50.30.20.20.10.40.1-0.1-0.10.00.2-0.1-0.2-0.20.1
Conditioned reinforcement - inactives3.74.17.1-0.9-0.40.52.0-2.22.12.2-2.2-2.22.72.2-2.1-1.72.7-2.6
Conditioned locomotion2.63.24.71.71.62.02.2-0.02.12.1-2.0-2.11.41.9-1.9-1.81.2-1.5
Patch foraging indifference point 0 sec0.00.10.1-0.30.1-0.20.2-0.20.40.3-0.3-0.30.30.2-0.10.10.2-0.2
Patch foraging indifference point AUC0.20.20.90.70.90.40.10.9-0.0-0.10.20.1-0.5-0.20.10.1-0.60.4
Delay disc. indifference point, 0s delay3.43.76.8-0.1-0.21.11.8-2.11.82.0-2.1-2.02.42.0-2.2-1.92.6-2.5
Delay disc. indifference point, 16s delay1.11.12.3-0.6-0.10.00.9-1.20.91.2-1.1-1.21.31.0-0.9-0.61.5-1.4
Delay disc. indifference point, 2s delay1.21.33.4-1.0-1.0-0.10.6-1.90.80.8-0.9-0.81.61.0-1.0-0.91.8-1.5
Delay disc. indifference point, 24s delay0.90.82.5-1.6-1.2-0.70.1-1.60.30.5-0.5-0.51.10.5-0.4-0.21.3-1.1
Delay disc. indifference point, 4s delay0.90.91.4-0.00.50.71.2-0.41.01.1-1.1-1.11.01.1-1.0-0.91.0-1.1
Delay disc. indifference point, 8s delay0.10.10.4-0.4-0.2-0.20.1-0.7-0.00.2-0.3-0.20.40.3-0.2-0.20.5-0.4
Indifference point function ln k0.10.20.5-0.7-0.7-0.6-0.4-0.5-0.5-0.30.20.30.1-0.30.20.50.3-0.1
Indifference point function log k0.10.20.5-0.7-0.7-0.6-0.4-0.5-0.5-0.30.20.30.1-0.30.20.50.3-0.1
Patch foraging total patch changes 0 sec0.10.10.2-0.5-0.1-0.30.2-0.40.40.2-0.3-0.20.40.3-0.10.00.3-0.3
Patch foraging total patch changes 12 sec0.20.20.6-0.00.5-0.2-0.10.8-0.1-0.30.30.3-0.6-0.40.40.6-0.70.6
Patch foraging total patch changes 18 sec0.30.30.70.2-0.00.30.6-0.50.80.6-0.6-0.60.70.8-0.6-0.80.5-0.6
Patch foraging total patch changes 24 sec0.60.72.3-0.9-1.1-0.40.2-1.50.60.5-0.6-0.51.20.7-0.5-0.71.1-1.0
Patch foraging total patch changes 6 sec0.00.10.2-0.20.3-0.3-0.10.40.0-0.10.10.1-0.2-0.10.30.3-0.40.3
Patch foraging time to switch 0 sec0.30.41.60.61.00.5-0.01.3-0.3-0.20.30.2-1.0-0.40.40.4-1.10.8
Patch foraging water rate 0 sec0.40.71.11.01.11.01.00.30.90.9-0.9-0.90.50.8-0.8-0.70.6-0.6
Patch foraging water rate 12 sec0.20.41.6-0.7-1.3-0.8-0.1-1.20.4-0.1-0.30.10.80.4-0.0-0.30.4-0.3
Patch foraging water rate 18 sec0.00.10.20.30.50.20.40.20.30.0-0.2-0.0-0.00.0-0.00.1-0.20.2
Patch foraging water rate 24 sec2.73.86.40.1-0.30.91.9-1.91.92.0-2.2-2.02.52.2-2.1-2.22.4-2.3
Patch foraging water rate 6 sec0.91.44.1-1.3-1.4-0.60.5-2.00.90.7-1.0-0.71.71.0-0.8-0.81.6-1.4
Seeking ratio, delayed vs. immediate footshock1.31.55.2-0.7-1.4-0.30.7-2.30.80.8-1.1-0.81.71.2-1.0-1.21.6-1.4
Distance traveled before self-admin0.10.10.1-0.3-0.1-0.2-0.30.1-0.4-0.30.20.3-0.2-0.30.20.4-0.30.3
Distance traveled after self-admin1.01.15.2-2.3-2.0-1.8-0.9-1.1-0.5-0.60.50.60.5-0.50.60.80.4-0.1
Extensor digitorum longus weight0.20.92.10.80.80.3-1.01.3-1.4-0.81.20.8-1.4-1.10.70.4-0.70.9
Bone: elastic displacement0.50.50.90.20.2-0.4-0.60.6-0.8-0.90.80.9-0.9-0.80.80.7-0.90.9
Bone: elastic work0.91.22.4-1.5-1.6-1.5-1.3-0.5-1.2-1.21.11.2-0.5-1.01.01.0-0.30.6
Bone: endosteal estimation0.61.24.5-2.1-1.9-1.7-1.1-1.4-0.9-0.80.50.80.2-0.60.80.90.20.1
Bone: endosteal perimeter0.40.83.2-1.8-1.7-1.4-0.5-1.7-0.4-0.30.00.30.6-0.10.30.50.6-0.3
Epididymis fat weight0.10.10.7-0.4-0.8-0.2-0.2-0.50.3-0.00.00.00.50.2-0.2-0.40.5-0.3
Delta time in closed arm before/after self-admin1.21.22.5-1.5-1.6-1.5-1.5-0.9-1.4-1.01.01.0-0.3-1.01.00.90.00.3
Delta time in open arm before/after self-admin0.20.21.40.50.70.40.11.20.60.00.20.0-0.4-0.00.2-0.0-0.60.4
Diff in mean of infusions in LGA sessions1.31.52.50.00.91.21.6-0.21.11.6-1.5-1.61.21.2-1.5-0.81.2-1.4
Delay discount exponential model param0.60.61.40.70.2-0.0-0.71.0-0.5-0.80.80.8-1.0-0.80.70.5-1.21.1
Extinction: sum of active levers before priming2.02.03.7-1.8-1.9-1.9-1.70.2-1.7-1.41.51.4-0.6-1.41.41.5-0.40.7
Active lever presses in extinction session 65.95.79.2-2.1-1.4-2.4-2.60.7-2.6-2.72.42.7-2.2-2.82.63.0-2.12.4
Bone: final force0.40.72.9-1.7-1.6-1.2-0.9-0.9-0.5-0.50.50.50.3-0.40.40.40.6-0.2
Bone: final moment0.61.03.7-1.9-1.8-1.5-1.2-0.9-0.8-0.70.80.70.1-0.60.70.60.5-0.1
Food consumed during 24 hour testing period0.70.92.5-1.0-0.8-0.30.5-1.60.50.8-0.9-0.81.30.9-0.7-0.61.3-1.2
Glucose0.50.81.50.50.2-0.2-0.81.0-0.9-1.00.91.0-1.1-0.90.80.6-1.21.2
Heart weight0.40.61.3-0.4-0.50.10.6-1.10.80.7-0.8-0.71.10.8-0.8-0.61.1-1.0
Delay discount hyperbolic model param0.70.71.70.50.2-0.2-0.81.0-0.6-0.90.90.9-1.1-0.90.80.7-1.31.2
Intermittent access intake day 1-15 change0.80.83.4-1.6-1.8-1.3-1.0-1.3-0.7-0.70.60.70.3-0.40.60.30.3-0.0
Intermittent access intake escalation0.70.73.3-1.5-1.8-1.1-0.7-1.5-0.5-0.40.30.40.6-0.10.30.00.6-0.3
Intermittent access intake escalation 20.80.82.2-1.5-1.3-1.3-1.0-0.6-0.8-0.90.70.9-0.2-0.80.90.8-0.30.4
Intermitt. access day 1 inactive lever presses0.80.84.8-2.2-1.3-1.4-0.6-1.0-0.8-0.20.30.20.3-0.40.50.90.5-0.3
Intermitt. access day 15 inactive lever presses1.11.22.2-0.5-0.20.21.0-1.20.91.2-1.2-1.21.41.1-1.0-0.81.5-1.5
Intermitt. access escalation Index1.11.01.70.40.10.80.9-0.71.31.1-1.1-1.11.11.1-1.2-1.11.1-1.1
Intermittent access day 1 total infusions4.45.18.12.01.42.22.6-0.82.92.5-2.5-2.52.02.6-2.5-2.61.8-2.1
Intermittent access day 15 total infusions3.64.06.00.6-0.11.11.9-1.92.42.1-2.2-2.12.42.3-2.1-2.32.3-2.3
Intermittent access terminal intake (last 3 days)3.74.06.60.80.41.32.1-1.52.62.2-2.3-2.22.32.3-2.2-2.22.0-2.1
Intermittent access total infusions3.74.27.01.30.51.52.2-1.42.72.2-2.4-2.22.22.4-2.2-2.31.9-2.1
Intermittent access day 1 locomotion5.05.37.71.01.11.92.7-1.22.82.6-2.7-2.62.42.6-2.6-2.42.2-2.4
Intermittent access day 15 total locomotion3.43.65.90.1-0.11.02.0-1.92.22.0-2.1-2.02.42.2-2.1-2.02.2-2.2
Intermittent access total locomotion3.13.55.21.11.11.72.3-0.72.32.2-2.2-2.11.82.1-2.1-2.01.6-1.8
Intermittent access standard deviation1.61.76.0-2.3-2.4-1.6-0.3-2.50.50.1-0.3-0.11.40.4-0.1-0.11.4-1.0
Left kidney weight2.46.911.5-2.5-3.2-3.2-3.4-0.2-3.2-3.03.03.0-1.6-2.62.82.3-1.31.8
Right kidney weight3.49.616.3-3.7-4.0-4.0-3.9-0.8-3.6-3.43.43.3-1.6-3.03.22.8-1.11.9
Cocaine induced anxiety0.30.40.9-1.0-0.5-0.7-0.70.0-0.6-0.60.70.6-0.4-0.60.60.8-0.20.3
Post-drug Anxiety0.20.20.70.20.70.1-0.00.8-0.2-0.10.20.1-0.6-0.30.30.5-0.50.3
Baseline Anxiety1.11.22.21.51.51.31.30.31.21.2-1.1-1.20.51.1-1.0-1.10.4-0.7
Tail length2.88.417.1-4.1-3.8-4.1-3.4-1.1-3.0-3.02.73.0-1.2-2.72.92.9-1.21.8
Length with tail3.412.331.6-5.6-5.5-5.3-4.1-2.7-3.3-3.43.03.3-0.5-2.83.13.0-0.31.3
Length without tail1.83.913.0-3.4-3.6-3.0-2.2-2.4-1.4-1.61.41.50.4-1.11.31.00.7-0.0
Times rat made contact with spout0.80.91.61.00.00.0-0.91.1-1.1-1.01.11.0-1.3-0.90.80.4-1.21.2
Lifetime Intake2.22.44.41.40.61.31.7-0.92.11.7-1.7-1.71.61.8-1.7-1.91.3-1.5
Liver weight, left0.50.92.41.00.60.2-0.71.6-0.5-0.81.00.8-1.4-0.90.80.5-1.11.1
Liver weight, right0.40.72.40.40.5-0.2-0.71.6-0.4-0.70.90.7-1.2-0.90.80.8-0.91.0
Locomotor activity1.72.75.50.80.8-0.4-1.12.3-1.2-1.51.71.5-2.2-1.81.61.7-2.32.1
Locomotor testing distance0.81.43.20.90.5-0.2-0.81.6-0.8-1.11.11.1-1.5-1.21.11.1-1.81.6
Locomotor testing rearing0.40.63.92.01.01.10.31.30.20.00.00.0-0.60.1-0.1-0.5-0.80.6
Locomotion in novel chamber0.30.31.10.21.00.20.11.0-0.4-0.10.20.1-0.7-0.50.30.9-0.60.5
Locomotion in novel chamber post-restriction0.10.10.4-0.40.4-0.10.00.2-0.40.1-0.1-0.1-0.3-0.30.10.7-0.20.2
Fecal boli incidents, locomotor time 10.80.83.71.51.91.10.91.7-0.10.4-0.3-0.3-0.7-0.1-0.30.4-0.70.5
Change in fecal boli incidents, locomotor task1.61.52.2-0.80.0-0.8-1.11.1-1.4-1.31.31.3-1.5-1.41.41.4-1.41.4
Time >=10cm from walls, locomotor time 10.10.10.20.50.20.10.00.30.1-0.20.10.2-0.3-0.00.1-0.1-0.40.3
Bouts of movement, locomotor time 11.31.53.0-0.6-0.70.11.0-1.71.01.1-1.3-1.21.71.2-1.2-0.91.6-1.5
Total resting periods, locomotor time 10.91.02.0-0.6-0.50.00.9-1.40.70.9-1.1-0.91.41.0-1.0-0.61.3-1.2
Rest time, locomotor task time 10.40.42.20.71.50.90.81.2-0.10.4-0.4-0.4-0.4-0.1-0.40.4-0.30.2
Distance moved, locomotor task time 10.10.10.7-0.1-0.6-0.1-0.2-0.8-0.2-0.1-0.10.10.40.3-0.2-0.70.3-0.3
Vertical activity count, locomotor time 10.70.73.1-1.8-1.6-1.2-0.7-1.5-0.2-0.20.20.20.60.00.3-0.00.6-0.4
Time >=10cm from walls, locomotor time 20.90.92.71.51.61.41.30.80.80.9-0.9-0.90.10.7-0.9-0.60.0-0.3
Bouts of movement, locomotor time 20.10.10.30.0-0.10.00.1-0.30.60.2-0.2-0.20.30.3-0.2-0.30.2-0.2
Total resting periods, locomotor time 20.00.00.2-0.00.20.00.10.10.50.1-0.1-0.10.10.1-0.1-0.0-0.10.1
Rest time, locomotor task time 20.20.21.00.11.00.40.50.9-0.00.1-0.2-0.1-0.4-0.20.00.6-0.60.4
Distance moved, locomotor task time 20.50.51.90.5-0.10.60.4-0.80.30.5-0.6-0.60.90.9-0.8-1.40.9-0.8
Vertical activity count, locomotor time 20.50.61.9-0.9-1.0-0.4-0.1-1.40.10.4-0.3-0.41.00.6-0.4-0.71.2-1.0
Light reinforcement 10.30.51.20.30.70.50.9-0.31.10.8-0.8-0.80.80.9-0.8-0.90.6-0.7
Light reinforcement 21.01.45.11.72.31.81.31.20.91.1-0.9-1.10.10.7-1.0-0.80.4-0.5
Bone: marrow area0.61.34.7-2.2-1.9-1.8-1.2-1.4-1.0-0.90.60.90.0-0.80.91.00.10.2
Bone: maximum diameter0.51.02.5-1.6-1.5-1.5-1.0-1.0-1.0-0.90.70.9-0.2-0.70.90.9-0.10.4
Bone: maximum force0.71.24.7-2.2-2.1-1.6-1.2-1.3-0.7-0.70.70.70.4-0.40.60.50.7-0.3
Bone: maximum moment0.91.55.5-2.3-2.2-1.8-1.4-1.4-0.9-0.90.80.80.3-0.60.70.60.7-0.2
Mean time between licks in bursts0.20.30.6-0.20.00.30.7-0.20.80.7-0.7-0.70.60.7-0.6-0.50.7-0.7
Mean num. licks in bursts3.44.15.7-1.2-1.4-1.9-2.40.8-2.3-2.32.32.3-1.9-2.32.22.2-1.72.0
Cd content in liver0.30.30.5-0.0-0.6-0.5-0.60.0-0.6-0.70.60.7-0.4-0.50.60.4-0.70.6
Co content in liver0.10.10.70.30.80.60.30.60.20.3-0.2-0.3-0.20.1-0.2-0.2-0.1-0.0
Cu content in liver0.20.21.0-0.9-1.0-0.5-0.3-0.7-0.1-0.10.10.10.30.00.1-0.10.5-0.3
Fe content in liver0.00.10.10.10.10.20.4-0.10.30.3-0.3-0.30.20.3-0.2-0.20.0-0.2
K content in liver0.00.00.1-0.30.2-0.10.30.10.20.2-0.2-0.20.00.10.00.20.1-0.0
Mg content in liver0.20.21.20.51.10.50.41.10.20.2-0.0-0.2-0.5-0.10.00.2-0.30.3
Mn content in liver0.91.03.20.81.30.3-0.11.8-0.5-0.60.60.6-1.4-0.80.81.0-1.51.3
Na content in liver0.50.52.2-1.2-1.2-0.80.0-1.50.10.1-0.4-0.20.90.4-0.1-0.20.7-0.6
Rb content in liver1.21.52.40.10.31.01.3-0.71.31.5-1.4-1.51.21.3-1.3-1.11.5-1.5
Se content in liver2.22.79.93.13.22.61.42.41.01.0-0.6-0.9-0.80.6-0.9-0.9-0.60.2
Sr content in liver0.50.41.10.81.00.4-0.01.1-0.3-0.40.30.4-0.8-0.40.40.4-1.10.8
Zn content in liver0.10.10.30.00.40.50.40.20.40.5-0.4-0.50.10.4-0.4-0.40.5-0.4
Bone: minimum diameter0.81.56.5-2.5-2.1-1.7-0.6-2.4-0.2-0.1-0.20.11.10.10.20.41.1-0.8
Time in familiar zone, hab. session 12.01.93.6-0.5-0.7-1.0-1.80.7-1.9-1.61.81.6-1.4-1.61.41.3-1.01.3
Time in novel zone, hab. session 12.52.54.41.11.41.52.1-0.31.91.9-2.0-1.91.41.8-1.6-1.50.9-1.3
Total zone transitions, hab. session 10.40.61.0-0.10.20.50.8-0.70.80.9-0.8-0.91.00.8-0.9-0.81.0-1.0
Total locomotion distance, hab. session 10.30.42.1-1.5-1.0-1.1-0.1-0.6-0.0-0.20.00.20.3-0.20.30.8-0.00.0
Locomotion velocity, hab. session 10.30.51.5-1.2-0.9-1.1-0.4-0.2-0.4-0.50.40.5-0.2-0.60.71.1-0.50.5
Time in familiar zone, hab. session 22.32.44.9-1.9-1.1-1.8-1.40.3-1.7-1.51.31.5-1.3-1.71.82.2-1.31.4
Time in novel zone, hab. session 20.80.82.41.61.01.20.80.20.90.7-0.6-0.70.50.9-0.9-1.30.5-0.6
Total zone transitions, hab. session 21.62.14.41.82.12.01.80.71.31.5-1.4-1.50.61.3-1.5-1.40.5-0.8
Total locomotion distance, hab. session 20.60.81.80.10.40.61.3-0.41.11.1-1.2-1.11.01.0-0.9-0.60.6-0.8
Locomotion velocity, hab. session 20.40.51.40.20.50.61.2-0.10.80.9-1.0-0.90.70.8-0.8-0.50.4-0.6
Novel to familiar place preference ratio0.20.20.4-0.20.10.00.2-0.70.60.3-0.4-0.30.60.5-0.3-0.50.5-0.5
Novelty place preference0.20.20.6-0.10.10.10.4-0.80.60.4-0.5-0.40.70.6-0.4-0.60.5-0.5
Time in novel zone, NPP test0.40.40.70.20.30.30.5-0.70.80.5-0.7-0.60.80.8-0.6-0.80.6-0.7
Total zone transitions, NPP test0.00.00.10.10.30.20.10.10.10.1-0.0-0.10.10.1-0.2-0.20.2-0.1
Total locomotion distance, NPP test1.21.63.8-1.9-1.8-2.0-1.3-0.5-1.1-1.31.11.3-0.4-1.11.31.4-0.50.8
Locomotion velocity, NPP test1.42.04.4-2.1-1.7-2.1-1.4-0.4-1.3-1.41.21.4-0.6-1.31.41.7-0.71.0
Intraocular pressure0.30.50.80.20.20.50.7-0.60.60.8-0.9-0.80.80.7-0.8-0.60.7-0.8
Delta distance traveled before/after self-admin1.11.24.7-2.2-2.2-1.8-0.9-1.4-0.3-0.50.50.50.6-0.30.60.50.7-0.4
Delta ambulatory time before/after self-admin1.41.56.4-2.5-2.4-1.9-0.9-1.8-0.3-0.50.30.50.8-0.30.50.50.8-0.5
Parametrial fat weight3.67.011.90.20.2-1.2-2.73.0-2.6-2.83.22.9-3.5-3.02.82.6-3.03.1
Pavlov. Cond. lever latency0.20.20.7-0.2-0.8-0.4-0.8-0.3-0.7-0.50.60.5-0.3-0.50.40.3-0.20.2
Pavlov. Cond. magazine entry latency0.20.20.70.60.70.10.20.8-0.1-0.30.00.3-0.4-0.10.30.3-0.80.7
Pavlov. Cond. change in total contacts1.31.42.10.21.00.81.5-0.51.41.3-1.5-1.31.21.4-1.2-1.11.1-1.1
Pavlov. Cond. index score0.20.21.20.51.10.40.60.80.40.2-0.3-0.2-0.20.2-0.10.0-0.40.3
Pavlov. Cond. latency score0.10.20.70.30.90.40.70.50.50.4-0.5-0.40.10.4-0.3-0.1-0.1-0.0
Pavlov. Cond. lever contacts0.10.10.3-0.40.5-0.10.50.10.40.3-0.4-0.30.20.3-0.20.20.2-0.2
Pavlov. Cond. magazine entry number0.10.20.7-0.7-0.8-0.4-0.5-0.7-0.3-0.10.30.10.2-0.20.10.10.4-0.3
Pavlov. Cond. intertrial magazine entries0.30.41.21.11.11.00.50.40.70.5-0.4-0.50.10.4-0.6-0.60.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.20.31.40.61.20.60.80.70.50.3-0.5-0.3-0.00.4-0.2-0.1-0.30.2
Pavlov. Cond. response bias0.30.31.00.20.7-0.2-0.11.0-0.3-0.50.30.5-0.7-0.50.50.7-0.90.8
Pavlov. Cond. lever latency1.31.77.22.72.32.11.21.80.50.8-0.7-0.7-0.60.5-0.7-0.8-0.70.2
Pavlov. Cond. magazine entry latency0.70.93.9-2.0-1.5-1.6-0.7-1.0-0.4-0.60.40.50.2-0.50.71.00.10.1
Pavlov. Cond. change in total contacts2.12.811.3-3.4-3.2-2.5-1.1-2.9-0.3-0.60.30.61.3-0.20.50.51.2-0.7
Pavlov. Cond. index score1.31.76.8-2.6-2.4-2.1-1.2-1.8-0.5-0.80.60.70.5-0.50.70.80.6-0.2
Pavlov. Cond. latency score1.21.56.4-2.5-2.2-2.0-1.0-1.8-0.4-0.60.50.60.6-0.40.60.80.6-0.2
Pavlov. Cond. lever contacts1.11.66.2-2.5-2.3-1.9-1.1-2.0-0.4-0.60.50.50.8-0.30.50.40.9-0.4
Pavlov. Cond. magazine entry number1.21.55.12.12.31.91.21.60.80.9-0.8-0.9-0.30.6-0.8-0.8-0.3-0.1
Pavlov. Cond. intertrial magazine entries0.30.41.21.01.11.00.50.80.40.5-0.3-0.4-0.10.4-0.4-0.6-0.2-0.0
Pavlov. Cond. lever-magazine prob. diff.1.41.86.6-2.6-2.4-2.2-1.3-1.7-0.7-0.90.80.90.3-0.70.91.00.30.0
Pavlov. Cond. response bias1.31.86.9-2.6-2.6-2.0-1.0-2.4-0.2-0.50.30.41.0-0.10.40.31.1-0.6
Time in closed arm before self-admin2.52.84.52.11.72.12.00.12.11.7-1.7-1.71.11.8-1.8-2.00.8-1.1
Time in closed arm after self-admin0.40.40.70.20.20.40.6-0.70.50.7-0.7-0.70.70.7-0.8-0.60.8-0.8
Time in open arm before self-admin3.74.07.0-2.6-2.0-2.6-2.3-0.6-2.4-2.21.82.1-1.2-2.02.12.2-1.21.5
Time in open arm after self-admin1.41.62.8-1.6-1.2-1.7-1.5-0.0-0.9-1.41.21.4-0.8-1.21.51.3-1.01.1
Bone: periosteal estimation0.81.74.5-2.1-2.0-2.0-1.5-1.3-1.3-1.21.01.2-0.2-1.01.11.2-0.00.5
Bone: periosteal perimeter0.81.32.7-1.4-1.3-1.6-1.2-0.6-1.3-1.20.91.2-0.6-1.11.21.4-0.60.8
Bone: post-yield work1.01.44.1-1.6-1.4-0.60.3-2.00.80.6-0.8-0.71.60.9-0.7-0.71.6-1.4
Progressive ratio test 1 active lever presses1.92.03.8-0.6-0.70.21.1-1.91.71.3-1.5-1.32.01.5-1.4-1.41.8-1.7
Progressive ratio test 1 breakpoint1.21.33.2-0.9-0.9-0.20.7-1.81.30.9-1.1-0.91.61.1-1.0-0.91.4-1.3
Progressive ratio test 1 inactive lever presses2.93.15.5-0.8-0.30.51.6-1.82.21.9-1.9-1.92.31.9-1.8-1.42.3-2.2
Progressive ratio test 2 active lever presses1.51.62.70.5-0.30.51.2-1.41.41.3-1.4-1.31.61.5-1.4-1.51.4-1.4
Progressive ratio test 2 breakpoint1.11.32.10.6-0.20.51.1-1.21.31.1-1.3-1.11.41.3-1.2-1.31.2-1.2
Progressive ratio test 2 inactive lever presses5.96.811.8-0.4-0.30.92.5-2.72.52.9-2.9-2.93.32.8-2.8-2.23.4-3.4
Incentive Sensitization - Responses0.50.50.80.9-0.00.50.7-0.60.50.7-0.7-0.70.80.8-0.8-0.90.6-0.7
Incentive Sensitization - Breakpoint0.40.40.80.9-0.10.50.6-0.60.30.6-0.6-0.60.70.7-0.7-0.90.6-0.6
Sum of active levers in priming session hrs 5-60.10.10.3-0.6-0.4-0.3-0.1-0.2-0.6-0.20.00.1-0.0-0.30.10.30.1-0.0
Progressive ratio0.00.00.4-0.30.1-0.10.20.10.6-0.0-0.10.00.00.00.00.3-0.20.1
Food seeking constrained by brief footshock1.11.35.0-2.2-1.7-1.9-1.0-1.0-0.3-0.90.70.90.0-0.81.01.3-0.20.4
Seeking ratio, punishment vs. effort0.20.20.9-0.7-0.7-0.5-0.1-1.00.10.2-0.2-0.20.60.2-0.1-0.10.6-0.5
Retroperitoneal fat weight0.72.27.62.21.81.0-0.62.8-0.6-1.01.21.0-2.0-1.10.80.4-1.81.7
Reaction time number correct0.00.10.1-0.2-0.1-0.1-0.30.2-0.4-0.30.30.3-0.2-0.30.20.2-0.10.2
Reaction time mean minus median0.20.30.7-0.5-0.8-0.8-0.7-0.5-0.6-0.60.50.6-0.2-0.40.60.2-0.30.4
Reaction time mean minus median AUC0.70.91.7-0.9-1.3-1.2-1.2-0.6-1.1-1.10.91.1-0.5-0.71.00.5-0.50.7
Reaction time num false alarms0.40.62.41.50.81.10.90.20.70.7-0.7-0.70.30.7-0.6-0.90.1-0.3
Reaction time num false alarms AUC0.40.62.71.61.01.11.00.40.70.7-0.7-0.70.10.6-0.6-0.7-0.1-0.2
Reaction time trials correct on left0.00.10.1-0.2-0.1-0.1-0.30.2-0.4-0.30.30.3-0.2-0.30.20.2-0.10.2
Reaction time trials on left0.10.10.2-0.1-0.1-0.1-0.30.3-0.4-0.30.40.3-0.3-0.40.30.3-0.10.2
Reaction time mean0.10.21.0-0.0-1.0-0.4-0.3-0.8-0.2-0.30.10.30.10.00.2-0.3-0.10.2
Reaction time mean AUC0.10.10.60.1-0.8-0.4-0.3-0.5-0.3-0.40.20.4-0.1-0.10.4-0.1-0.30.4
Median of all reaction times0.10.10.60.2-0.8-0.2-0.0-0.70.1-0.1-0.10.10.20.20.0-0.40.00.1
Reaction time omissions0.30.40.80.2-0.3-0.4-0.60.5-0.6-0.80.70.8-0.9-0.70.80.6-0.80.9
Reaction time false alarm rate0.40.62.01.40.81.01.00.10.80.8-0.8-0.80.30.8-0.7-0.80.0-0.3
Reaction time premature initiation rate0.60.81.5-0.50.00.21.1-0.91.11.1-1.2-1.11.21.0-0.9-0.50.8-1.0
Reaction time premature initiations0.40.61.1-0.6-0.00.20.9-0.70.90.9-1.0-0.91.00.8-0.8-0.30.8-0.9
Std. dev. reaction times0.20.31.6-0.6-1.3-0.8-0.5-1.2-0.3-0.40.10.40.30.00.3-0.30.20.0
Reaction time trials completed0.10.10.2-0.1-0.1-0.1-0.30.3-0.4-0.30.40.3-0.3-0.40.30.3-0.10.2
Reaction time trials AUC0.20.30.5-0.0-0.0-0.2-0.50.6-0.7-0.60.70.6-0.6-0.70.50.5-0.50.5
Run reversals in cocaine runway, females0.40.41.1-0.5-1.1-0.3-0.0-1.00.10.2-0.2-0.20.80.4-0.3-0.60.9-0.7
Run reversals in cocaine runway, males4.74.67.7-0.10.4-1.0-1.92.4-2.0-2.32.42.3-2.8-2.32.42.2-2.72.7
Latency to leave start box in cocaine runway0.91.02.0-0.3-0.80.30.6-1.40.80.9-0.9-0.91.31.0-1.0-1.21.4-1.3
Latency to leave start box in cocaine runway, F1.11.22.5-0.1-0.20.60.9-1.00.91.2-1.0-1.21.31.2-1.2-1.31.6-1.5
Latency to leave start box in cocaine runway, M0.10.10.4-0.1-0.7-0.2-0.3-0.4-0.0-0.30.10.30.0-0.10.10.0-0.20.2
Std. dev. time between licks in bursts1.92.34.0-1.00.00.41.7-1.32.01.8-1.9-1.81.91.6-1.5-0.91.6-1.8
Total sessions with >9 infusions0.40.41.61.30.90.90.60.50.70.4-0.4-0.40.00.5-0.4-0.8-0.20.0
Short access day 1 total inactive lever presses4.55.18.4-0.2-0.01.12.3-2.02.12.6-2.5-2.62.82.4-2.4-2.02.9-2.9
Short access day 10 total inactive lever presses0.60.71.9-1.3-0.9-0.50.3-1.20.20.7-0.6-0.71.10.4-0.5-0.01.4-1.2
Short access day 1 total infusions0.30.40.80.50.20.50.5-0.40.70.6-0.6-0.60.60.7-0.7-0.90.5-0.6
Short access day 10 total infusions0.50.61.41.10.50.80.7-0.21.20.7-0.8-0.70.50.8-0.7-1.00.4-0.5
Short access total infusions0.40.42.01.40.70.90.60.30.90.4-0.5-0.40.10.6-0.5-0.8-0.1-0.1
Short access day 1 locomotion0.20.30.60.40.50.60.50.00.60.5-0.4-0.50.40.6-0.5-0.80.4-0.4
Short access day 10 total locomotion1.01.22.2-1.1-0.5-0.21.0-1.41.41.0-1.1-1.01.51.1-0.9-0.61.3-1.2
Short access total locomotion0.80.81.70.81.11.01.20.11.31.0-0.9-1.00.51.0-0.9-0.90.4-0.6
One hour access (0.3 mA shock)1.82.15.0-0.6-1.1-0.31.1-2.21.81.2-1.5-1.22.11.5-1.2-1.21.6-1.6
Compulsive drug intake0.10.10.1-0.1-0.1-0.3-0.20.00.2-0.30.20.3-0.2-0.20.30.3-0.20.3
One hour access (shock baseline)1.51.82.90.3-0.20.51.4-1.41.61.4-1.5-1.41.71.6-1.4-1.41.5-1.5
Social response proportion0.40.42.1-1.5-0.8-0.9-0.3-1.0-0.60.00.0-0.10.5-0.10.10.50.8-0.6
Social responses0.10.21.3-1.10.2-0.60.1-0.3-0.30.1-0.0-0.10.1-0.20.20.90.2-0.2
Social time0.91.25.5-1.9-1.7-1.2-0.2-2.30.10.1-0.4-0.21.30.3-0.2-0.11.3-1.0
Soleus weight0.10.20.50.30.70.2-0.20.7-0.4-0.20.30.2-0.6-0.40.30.3-0.40.4
Bone: stiffness0.30.52.1-1.5-1.4-0.9-0.7-1.0-0.2-0.20.20.20.5-0.10.10.20.9-0.5
Tibialis anterior weight0.62.03.70.30.2-0.4-1.61.3-1.9-1.51.81.5-1.9-1.71.41.0-1.31.5
Time to tail flick, vehicle, before self-admin0.60.61.51.21.01.10.90.11.10.8-0.7-0.80.30.7-0.8-0.80.3-0.4
Time to tail flick, vehicle, after self-admin0.20.20.7-0.30.5-0.20.10.50.3-0.20.10.2-0.4-0.40.30.8-0.70.5
Time to tail flick, test, before self-admin4.03.97.31.1-0.01.41.8-1.62.12.0-1.9-2.02.32.4-2.1-2.72.4-2.3
Time to tail flick, test, after self-admin0.10.10.2-0.00.10.10.3-0.10.40.3-0.3-0.30.40.3-0.3-0.30.4-0.4
Delta time to tail flick, vehicle, before/after SA0.40.41.5-1.2-0.5-0.9-0.50.0-0.2-0.50.50.5-0.2-0.50.60.8-0.50.5
Delta time to tail flick, test, before/after SA2.92.64.7-0.40.7-0.7-1.22.0-1.4-1.61.61.6-2.0-1.91.72.1-2.22.0
Tibia length0.92.69.8-2.6-3.1-2.3-2.0-1.9-1.5-1.31.31.30.3-0.91.00.60.8-0.1
Ambulatory time before self-admin0.00.00.1-0.20.2-0.00.00.3-0.3-0.0-0.10.0-0.1-0.10.00.3-0.20.2
Ambulatory time after self-admin1.82.09.8-3.1-2.7-2.2-0.8-1.8-0.4-0.30.20.31.1-0.30.40.71.1-0.7
Bone: tissue strength1.31.33.5-1.9-1.8-0.8-0.1-1.90.50.4-0.4-0.51.40.7-0.5-0.71.6-1.3
Total heroin consumption0.50.51.1-0.7-0.6-0.00.7-0.80.50.8-0.8-0.81.00.6-0.7-0.41.0-1.0
Bone: trabecular number0.50.72.6-1.6-1.6-1.3-1.0-0.8-0.6-0.70.70.70.2-0.40.50.40.4-0.0
Bone: trabecular spacing0.81.02.1-0.5-0.3-1.0-0.80.5-0.7-1.00.81.0-1.0-1.11.21.5-1.51.2
Bone: trabecular thickness0.10.10.40.4-0.20.2-0.1-0.1-0.2-0.00.20.00.10.2-0.2-0.60.4-0.2
Bone: trabecular tissue density2.43.47.22.11.60.4-1.02.6-1.5-1.51.61.5-2.5-1.71.51.2-2.72.4
Water consumed over 24 hours0.20.20.6-0.7-0.8-0.6-0.5-0.5-0.6-0.30.30.30.1-0.20.20.10.3-0.1
Number of responses in last shaping day2.12.23.10.00.20.81.5-1.21.71.6-1.7-1.61.81.7-1.7-1.51.7-1.7