Hub : Genes

Prkd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Prkd1	0.22	0.16	1.2e-09	0.06	0.09	0.1	0.09	2.1e-06	4.1e-09	3.8e-09	6.8e-09
2	Liver	alternative polyA	XM_063262561.1	0.03	0.02	7.6e-04	0.01	0.02	0.02	0.02	7.3e-03	1.5e-03	2.1e-03	5.0e-03
3	pVTA	isoform ratio	NM_001276715.2	0.03	0.03	7.1e-03	0.02	0.03	0.01	0.01	1.6e-02	3.7e-03	5.7e-02	2.0e-02
4	PL	gene expression	Prkd1	0.03	0.02	1.3e-03	0.03	0.03	0.02	0.02	7.3e-04	8.9e-04	1.6e-03	1.0e-03
5	Liver	gene expression	Prkd1	0.11	0.06	0.0e+00	0.18	0.17	0.18	0.18	6.4e-20	2.5e-18	2.9e-19	1.9e-19
6	IC	gene expression	Prkd1	0.11	0.08	2.3e-04	0.06	0.07	0.05	0.06	1.8e-03	5.0e-04	2.8e-03	1.9e-03
7	Adipose	alternative TSS	XM_039113019.2	0.49	0.17	4.1e-03	-0	0.02	0.03	0	9.5e-01	2.8e-03	6.1e-04	3.7e-01
8	NAcc	gene expression	Prkd1	0.18	0.1	0.0e+00	0.15	0.15	0.14	0.16	1.6e-22	2.5e-22	2.5e-20	8.8e-23

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bone: apparent density	3.7	6.3	11.2	3.3	-2.9	2.8	2.7	2.8	2.7	0.9	0.0
Area under the delay curve	0.2	0.2	0.5	-0.7	0.5	-0.6	-0.4	-0.4	-0.5	-0.2	0.0
BMI with tail	0.7	2.6	4.1	1.7	-1.8	1.7	2.0	2.0	1.8	-0.2	0.0
BMI without tail	2.3	7.1	10.6	3.3	-3.1	2.9	3.2	3.2	2.9	0.0	0.0
Body weight	2.4	10.5	14.3	3.7	-3.7	3.7	3.8	3.7	3.7	0.8	0.0
Weight adjusted by age	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.4	-0.4	-0.5	-0.1	0.0
Bone surface	2.1	3.9	8.3	2.9	-2.2	2.1	2.2	2.2	2.0	-0.4	0.0
Bone volume	3.2	5.8	11.8	3.4	-2.7	2.6	2.6	2.6	2.5	0.4	0.0
Breakpoint value in progressive ratio session	3.1	3.7	6.1	1.5	-2.2	2.1	2.4	2.5	2.3	-1.2	0.0
Number of licking bursts	0.2	0.3	0.9	-0.9	0.4	-0.4	-0.4	-0.3	-0.4	-0.9	0.0
Context. condit. distance diff. score	0.8	1.0	1.8	1.3	-1.1	1.1	0.9	0.9	1.1	0.9	0.0
Locomotion velocity, session 1	0.2	0.2	0.7	0.6	-0.3	0.3	0.2	0.3	0.3	0.9	0.0
Locomotion distance, session 1	1.1	1.4	1.9	-1.4	1.3	-1.3	-1.4	-1.4	-1.3	-0.7	0.0
Locomotion velocity, session 2	2.7	3.2	4.5	-1.9	2.1	-2.0	-2.1	-2.1	-2.0	-0.1	0.0
Locomotion distance, session 2	2.9	4.0	5.1	-2.1	2.2	-2.3	-2.2	-2.2	-2.3	-1.6	0.0
Locomotion velocity, session 3	2.0	2.3	3.8	-1.0	1.8	-1.7	-2.0	-2.0	-1.9	0.7	0.0
Locomotion distance, session 3	0.4	0.4	0.6	-0.5	0.7	-0.7	-0.7	-0.7	-0.8	-0.6	0.0
Stereotopy head waving bouts, day 3	2.0	2.3	3.2	-1.5	1.7	-1.7	-1.8	-1.8	-1.7	0.9	0.0
Stereotopy head waving duration, day 3	1.5	1.8	2.5	-1.4	1.5	-1.5	-1.6	-1.6	-1.5	0.9	0.0
Locomotion velocity, session 7	0.1	0.1	0.2	0.2	0.3	-0.3	-0.3	-0.3	-0.4	0.1	0.0
Locomotion distance, session 7	0.1	0.1	0.5	0.7	-0.1	0.1	0.0	0.0	-0.0	0.1	0.0
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.2	0.2	-0.2	-0.3	-0.3	-0.2	0.4	0.0
Stereotopy head waving duration, day 7	0.6	0.7	1.2	-1.1	0.9	-0.9	-1.0	-1.0	-0.8	-0.1	0.0
Locomotion velocity, session 8	0.2	0.2	1.3	-0.0	0.2	-0.1	-0.3	-0.3	-0.1	1.1	0.0
Locomotion distance, session 8	0.1	0.1	0.2	0.1	0.3	-0.2	-0.5	-0.5	-0.3	0.4	0.0
Degree of sensitization distance	0.3	0.3	0.7	0.8	-0.5	0.5	0.4	0.4	0.4	0.8	0.0
Degree of sensitization stereotypy	0.4	0.5	0.7	0.7	-0.8	0.8	0.8	0.8	0.8	-0.0	0.0
Conditioned locomotion	1.8	2.1	3.3	-1.0	1.6	-1.5	-1.8	-1.8	-1.6	1.4	0.0
Cocaine response after cond. corrected	0.0	0.1	0.1	0.3	0.2	-0.2	-0.3	-0.3	-0.3	0.2	0.0
Cocaine response after cond. not corrected	0.2	0.2	0.8	0.9	-0.5	0.5	0.4	0.4	0.4	0.1	0.0
Cocaine response before conditioning	0.5	0.5	0.9	0.5	-0.8	0.7	1.0	0.9	0.8	-0.7	0.0
Saline control response	1.3	1.8	4.6	1.3	-1.3	1.3	1.2	1.1	1.3	2.1	0.0
Bone: connectivity density	5.8	9.1	15.7	4.0	-3.4	3.3	3.2	3.2	3.2	1.7	0.0
Bone: cortical apparent density	0.2	0.3	1.4	-0.1	0.3	-0.2	-0.5	-0.5	-0.3	1.2	0.0
Bone: cortical area	0.8	1.2	2.6	1.6	-1.2	1.2	1.1	1.2	1.1	0.3	0.0
Bone: cortical porosity	0.0	0.0	0.1	-0.2	0.3	-0.2	-0.3	-0.2	-0.2	0.3	0.0
Bone: cortical porosity	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.2	-0.2	-0.2	-0.1	0.0
Bone: cortical thickness	0.3	0.5	1.0	1.0	-0.8	0.8	0.8	0.8	0.7	-0.0	0.0
Bone: cortical thickness	0.1	0.1	0.3	-0.6	0.3	-0.3	-0.2	-0.2	-0.3	-0.5	0.0
Bone: cortical tissue density	0.2	0.3	1.4	-0.1	0.3	-0.2	-0.5	-0.5	-0.3	1.2	0.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.0	-0.6	0.6	0.6	0.6	0.6	-0.2	0.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.1	-0.3	0.3	0.3	0.3	0.4	-0.4	0.0
Condit. Reinf. active responses	0.2	0.2	0.4	0.1	-0.5	0.5	0.6	0.6	0.6	-0.3	0.0
Condit. Reinf. inactive responses	0.0	0.1	0.2	0.1	-0.2	0.1	0.3	0.3	0.1	-0.5	0.0
Incentive salience index mean	0.1	0.1	0.4	-0.2	-0.3	0.3	0.4	0.4	0.4	-0.7	0.0
Condit. Reinf. lever presses	0.2	0.3	2.0	-0.6	0.2	-0.3	-0.0	-0.0	-0.2	-1.4	0.0
Condit. Reinf. active minus inactive responses	0.2	0.3	0.6	-0.5	0.6	-0.6	-0.5	-0.5	-0.7	-0.8	0.0
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.3	-0.5	0.5	-0.6	-0.4	-0.4	-0.6	-1.1	0.0
Condit. Reinf. active responses	0.3	0.4	0.7	-0.5	0.7	-0.8	-0.7	-0.7	-0.8	-0.5	0.0
Condit. Reinf. inactive responses	0.0	0.1	0.2	0.3	-0.2	0.2	0.1	0.1	0.2	0.4	0.0
Condit. Reinf. lever presses	1.3	1.8	2.8	1.3	-1.5	1.4	1.7	1.7	1.5	-0.2	0.0
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	0.2	0.1	-0.1	-0.1	-0.1	-0.2	0.2	0.0
Conditioned reinforcement - actives	0.7	1.3	1.8	1.3	-1.2	1.2	1.3	1.3	1.2	0.8	0.0
Conditioned reinforcement - inactives	2.5	3.7	5.8	2.4	-2.2	2.2	2.1	2.1	2.2	1.2	0.0
Conditioned locomotion	0.7	0.9	4.8	1.4	-0.4	0.5	0.4	0.4	0.3	2.2	0.0
Patch foraging indifference point 0 sec	0.1	0.1	0.2	0.2	-0.4	0.3	0.3	0.4	0.4	-0.4	0.0
Patch foraging indifference point AUC	0.6	0.8	3.0	-0.6	0.8	-0.6	-0.9	-0.9	-0.7	1.7	0.0
Delay disc. indifference point, 0s delay	0.3	0.3	1.7	0.0	-0.4	0.2	0.6	0.6	0.4	-1.3	0.0
Delay disc. indifference point, 16s delay	0.3	0.3	0.5	-0.6	0.7	-0.7	-0.7	-0.7	-0.7	0.4	0.0
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	0.1	0.0	-0.1	0.0	0.0	-0.0	0.2	0.0
Delay disc. indifference point, 24s delay	0.2	0.2	1.0	-1.0	0.5	-0.6	-0.3	-0.3	-0.4	-0.2	0.0
Delay disc. indifference point, 4s delay	0.9	0.9	1.6	-1.3	1.1	-1.1	-1.0	-1.0	-1.0	-0.3	0.0
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.5	0.4	-0.5	-0.3	-0.3	-0.3	0.1	0.0
Indifference point function ln k	0.2	0.3	1.3	0.6	-0.5	0.4	0.4	0.5	0.4	-1.2	0.0
Indifference point function log k	0.2	0.3	1.3	0.6	-0.5	0.4	0.4	0.5	0.4	-1.2	0.0
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	0.2	-0.3	0.2	0.2	0.3	0.3	0.0	0.0
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	-0.3	-0.2	0.3	0.3	0.3	0.4	0.1	0.0
Patch foraging total patch changes 18 sec	0.2	0.2	1.1	-1.0	0.4	-0.4	-0.3	-0.3	-0.2	-0.6	0.0
Patch foraging total patch changes 24 sec	0.1	0.1	0.9	0.2	-0.0	0.1	0.1	0.0	0.0	1.0	0.0
Patch foraging total patch changes 6 sec	0.3	0.4	0.5	0.5	-0.7	0.7	0.7	0.7	0.7	0.7	0.0
Patch foraging time to switch 0 sec	0.2	0.5	3.5	-0.5	-0.1	0.0	0.3	0.2	0.1	-1.9	0.0
Patch foraging water rate 0 sec	0.2	0.5	2.8	0.3	0.4	-0.3	-0.5	-0.5	-0.5	1.7	0.0
Patch foraging water rate 12 sec	1.4	3.0	6.0	2.5	-1.8	1.8	1.7	1.7	1.6	1.9	0.0
Patch foraging water rate 18 sec	0.3	0.5	1.0	1.0	-0.7	0.7	0.7	0.7	0.7	0.5	0.0
Patch foraging water rate 24 sec	0.8	1.1	6.3	1.3	-0.4	0.5	0.2	0.2	0.3	2.5	0.0
Patch foraging water rate 6 sec	0.4	0.6	2.0	1.4	-0.8	0.8	0.8	0.7	0.6	0.5	0.0
Seeking ratio, delayed vs. immediate footshock	3.2	4.0	5.5	-2.2	2.3	-2.3	-2.3	-2.2	-2.3	0.4	0.0
Distance traveled before self-admin	0.2	0.3	1.9	0.2	0.2	-0.3	-0.0	-0.0	-0.3	-1.4	0.0
Distance traveled after self-admin	0.2	0.2	0.9	0.9	-0.5	0.5	0.5	0.4	0.4	0.1	0.0
Extensor digitorum longus weight	4.7	18.5	25.0	5.0	-4.9	4.8	5.0	5.0	4.9	1.4	0.0
Bone: elastic displacement	0.2	0.3	1.7	-0.1	-0.2	0.3	0.1	0.1	0.3	1.3	0.0
Bone: elastic work	1.2	1.5	2.3	1.5	-1.4	1.4	1.4	1.4	1.3	0.3	0.0
Bone: endosteal estimation	0.0	0.1	0.3	0.6	0.1	-0.1	-0.1	-0.1	-0.2	-0.5	0.0
Bone: endosteal perimeter	0.0	0.1	0.1	0.2	0.2	-0.2	-0.3	-0.3	-0.3	-0.1	0.0
Epididymis fat weight	0.2	0.8	1.1	0.9	-1.0	1.0	1.0	1.0	1.0	0.4	0.0
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	0.4	-0.5	0.6	0.7	0.7	0.6	0.5	0.0
Delta time in open arm before/after self-admin	0.9	0.9	1.4	0.7	-1.1	1.0	1.2	1.2	1.1	-1.0	0.0
Diff in mean of infusions in LGA sessions	0.5	0.6	1.3	-0.9	0.7	-0.9	-0.6	-0.6	-0.7	-1.2	0.0
Delay discount exponential model param	0.4	0.5	0.8	0.9	-0.8	0.9	0.7	0.7	0.7	0.2	0.0
Extinction: sum of active levers before priming	2.7	3.0	4.5	1.3	-2.0	2.0	2.1	2.1	2.1	0.7	0.0
Active lever presses in extinction session 6	3.4	3.4	5.4	1.7	-2.1	2.1	2.3	2.3	2.1	-0.1	0.0
Bone: final force	0.4	0.7	2.3	1.5	-0.9	0.8	0.8	0.8	0.7	-0.3	0.0
Bone: final moment	0.5	0.8	2.9	1.7	-0.9	0.9	0.9	0.9	0.7	-0.2	0.0
Food consumed during 24 hour testing period	0.3	0.5	1.5	0.2	-0.6	0.5	0.7	0.8	0.7	-1.2	0.0
Glucose	2.2	3.5	9.2	1.7	-1.7	1.8	1.7	1.7	1.8	3.0	0.0
Heart weight	1.1	1.7	2.5	1.6	-1.5	1.5	1.5	1.5	1.5	0.4	0.0
Delay discount hyperbolic model param	0.4	0.5	0.9	0.9	-0.8	0.9	0.7	0.7	0.7	0.2	0.0
Intermittent access intake day 1-15 change	2.0	4.0	5.8	2.2	-2.3	2.3	2.3	2.4	2.3	-0.2	0.0
Intermittent access intake escalation	1.3	2.7	3.8	1.9	-1.9	1.9	1.9	1.9	1.9	0.1	0.0
Intermittent access intake escalation 2	1.6	1.8	3.2	1.8	-1.5	1.5	1.5	1.5	1.5	-0.2	0.0
Intermitt. access day 1 inactive lever presses	0.2	0.6	0.8	0.7	-0.9	0.8	0.8	0.9	0.8	-0.8	0.0
Intermitt. access day 15 inactive lever presses	0.4	0.9	1.5	0.7	-1.1	1.1	1.1	1.1	1.2	-0.4	0.0
Intermitt. access escalation Index	0.0	0.0	0.2	-0.4	0.1	-0.0	-0.1	-0.1	-0.0	-0.3	0.0
Intermittent access day 1 total infusions	0.3	0.4	1.5	-0.4	0.6	-0.5	-0.7	-0.7	-0.6	1.2	0.0
Intermittent access day 15 total infusions	0.9	1.3	2.4	1.5	-1.1	1.2	1.0	1.0	1.2	1.5	0.0
Intermittent access terminal intake (last 3 days)	0.7	1.0	1.6	1.3	-1.0	1.0	0.9	1.0	1.0	1.2	0.0
Intermittent access total infusions	0.6	0.7	1.1	1.0	-0.8	0.9	0.8	0.8	0.9	1.0	0.0
Intermittent access day 1 locomotion	0.0	0.0	0.2	0.2	-0.1	0.1	0.2	0.1	0.1	0.5	0.0
Intermittent access day 15 total locomotion	0.8	1.5	3.1	1.7	-1.3	1.2	1.4	1.4	1.2	0.8	0.0
Intermittent access total locomotion	0.7	0.9	1.5	1.2	-1.0	1.0	1.0	1.0	1.0	0.7	0.0
Intermittent access standard deviation	0.9	1.8	2.7	1.6	-1.6	1.5	1.5	1.5	1.5	-0.3	0.0
Left kidney weight	1.8	8.5	14.6	3.8	-3.3	3.1	3.4	3.4	3.1	0.6	0.0
Right kidney weight	1.1	5.1	7.8	2.8	-2.6	2.5	2.6	2.6	2.5	0.4	0.0
Cocaine induced anxiety	1.5	2.1	4.9	-2.2	1.4	-1.5	-1.1	-1.1	-1.3	-1.9	0.0
Post-drug Anxiety	0.7	0.8	1.7	-1.3	1.0	-1.0	-0.9	-0.9	-0.9	-0.5	0.0
Baseline Anxiety	1.3	1.5	5.2	1.9	-0.9	1.0	0.6	0.6	0.8	2.3	0.0
Tail length	1.8	7.1	10.7	3.3	-3.1	3.0	3.1	3.0	3.0	0.3	0.0
Length with tail	1.8	7.7	10.5	3.2	-3.2	3.2	3.1	3.1	3.2	1.2	0.0
Length without tail	0.5	1.5	2.2	1.2	-1.4	1.4	1.5	1.5	1.4	0.5	0.0
Times rat made contact with spout	0.2	0.2	0.6	-0.7	0.6	-0.6	-0.5	-0.5	-0.5	0.2	0.0
Lifetime Intake	1.0	1.2	2.0	1.4	-1.1	1.1	1.0	1.0	1.1	1.4	0.0
Liver weight, left	3.1	5.1	6.6	2.5	-2.5	2.5	2.6	2.6	2.6	1.4	0.0
Liver weight, right	1.3	2.3	3.5	1.5	-1.8	1.8	1.8	1.8	1.9	0.4	0.0
Locomotor activity	6.4	10.0	14.9	3.4	-3.6	3.5	3.9	3.9	3.6	-0.1	0.0
Locomotor testing distance	4.5	8.1	11.7	3.1	-3.3	3.2	3.4	3.4	3.3	0.3	0.0
Locomotor testing rearing	3.8	7.7	11.3	2.9	-3.2	3.1	3.4	3.3	3.2	0.6	0.0
Locomotion in novel chamber	0.9	1.1	2.0	-0.6	1.2	-1.1	-1.4	-1.4	-1.2	0.6	0.0
Locomotion in novel chamber post-restriction	1.9	3.1	4.7	-1.4	2.1	-2.1	-2.2	-2.2	-2.1	0.7	0.0
Fecal boli incidents, locomotor time 1	2.6	3.8	5.4	2.2	-2.3	2.2	2.3	2.3	2.2	-0.4	0.0
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.1	-0.2	0.1	0.3	0.3	0.2	0.0	0.0
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.2	0.4	-0.7	0.7	0.8	0.8	0.7	-1.1	0.0
Bouts of movement, locomotor time 1	0.7	0.8	1.6	0.5	-0.9	0.8	1.0	1.0	0.8	-1.3	0.0
Total resting periods, locomotor time 1	0.7	0.8	1.8	0.5	-0.9	0.7	1.0	1.0	0.8	-1.4	0.0
Rest time, locomotor task time 1	0.2	0.2	1.3	-0.7	0.1	-0.2	0.1	0.1	-0.0	-1.1	0.0
Distance moved, locomotor task time 1	0.2	0.3	1.9	0.8	-0.2	0.3	0.0	0.1	0.2	1.4	0.0
Vertical activity count, locomotor time 1	0.4	0.9	2.4	1.5	-0.9	1.0	0.8	0.8	0.9	1.0	0.0
Time >=10cm from walls, locomotor time 2	0.5	0.7	2.0	-0.1	-0.8	0.8	0.9	0.9	0.9	-1.4	0.0
Bouts of movement, locomotor time 2	0.4	0.6	1.6	-0.9	0.8	-0.6	-0.7	-0.8	-0.7	1.3	0.0
Total resting periods, locomotor time 2	0.3	0.6	1.1	-0.9	0.8	-0.6	-0.7	-0.8	-0.7	1.1	0.0
Rest time, locomotor task time 2	0.1	0.1	0.3	0.2	-0.4	0.3	0.5	0.5	0.4	-0.0	0.0
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.0	0.1	-0.0	-0.1	-0.0	-0.0	0.3	0.0
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.3	0.1	-0.1	-0.2	-0.2	-0.1	0.1	0.0
Light reinforcement 1	0.4	1.0	1.3	1.1	-1.0	1.0	1.0	1.1	1.0	1.1	0.0
Light reinforcement 2	1.0	1.6	2.1	-1.2	1.4	-1.4	-1.4	-1.3	-1.4	-1.2	0.0
Bone: marrow area	0.0	0.1	0.4	0.6	0.0	-0.1	-0.0	-0.0	-0.2	-0.5	0.0
Bone: maximum diameter	0.1	0.2	0.7	0.8	-0.4	0.3	0.4	0.3	0.2	-0.5	0.0
Bone: maximum force	0.3	0.6	2.0	1.4	-0.8	0.7	0.7	0.7	0.6	-0.3	0.0
Bone: maximum moment	0.3	0.6	2.3	1.5	-0.8	0.7	0.7	0.7	0.6	-0.3	0.0
Mean time between licks in bursts	0.7	1.7	4.2	1.5	-1.2	1.3	1.0	1.0	1.2	2.1	0.0
Mean num. licks in bursts	0.2	0.3	1.1	0.8	-0.4	0.4	0.4	0.4	0.4	1.1	0.0
Cd content in liver	0.8	0.8	2.2	1.1	-0.8	0.9	0.7	0.7	0.9	1.5	0.0
Co content in liver	1.2	1.4	3.2	1.8	-1.3	1.3	1.3	1.3	1.2	0.3	0.0
Cu content in liver	0.1	0.2	0.3	-0.1	0.5	-0.6	-0.5	-0.5	-0.6	-0.2	0.0
Fe content in liver	0.5	0.6	3.7	0.7	-0.4	0.2	0.5	0.5	0.2	-1.9	0.0
K content in liver	7.6	7.3	10.1	-2.7	3.1	-3.1	-3.0	-3.0	-3.2	-2.0	0.0
Mg content in liver	6.2	6.3	8.7	-2.6	2.9	-2.9	-2.9	-2.9	-2.9	-1.2	0.0
Mn content in liver	3.7	4.1	6.1	-1.9	2.4	-2.3	-2.5	-2.5	-2.5	0.1	0.0
Na content in liver	2.8	3.0	6.0	-2.0	1.7	-1.8	-1.5	-1.5	-1.8	-2.4	0.0
Rb content in liver	1.2	1.4	1.8	-1.2	1.3	-1.3	-1.2	-1.2	-1.3	-1.2	0.0
Se content in liver	4.0	4.7	10.1	-2.0	2.1	-2.3	-2.1	-2.1	-2.3	-3.2	0.0
Sr content in liver	0.6	0.5	0.7	0.8	-0.7	0.8	0.7	0.7	0.8	0.8	0.0
Zn content in liver	1.5	1.6	2.6	-1.6	1.5	-1.5	-1.3	-1.3	-1.4	-1.1	0.0
Bone: minimum diameter	0.3	0.5	1.2	1.1	-0.8	0.8	0.7	0.8	0.7	-0.2	0.0
Time in familiar zone, hab. session 1	0.7	0.7	1.0	1.0	-0.9	0.9	1.0	1.0	0.9	0.5	0.0
Time in novel zone, hab. session 1	0.2	0.2	1.1	-0.1	0.3	-0.2	-0.4	-0.4	-0.3	1.1	0.0
Total zone transitions, hab. session 1	3.2	4.5	6.3	-2.5	2.5	-2.4	-2.4	-2.4	-2.4	-0.7	0.0
Total locomotion distance, hab. session 1	2.7	3.8	6.7	-2.6	2.2	-2.2	-2.0	-2.0	-2.1	-1.4	0.0
Locomotion velocity, hab. session 1	4.3	6.1	10.7	-3.3	2.7	-2.7	-2.5	-2.5	-2.6	-2.0	0.0
Time in familiar zone, hab. session 2	0.7	0.8	1.2	0.5	-1.0	0.9	1.1	1.1	1.0	-0.9	0.0
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.2	0.4	-0.3	-0.4	-0.4	-0.3	0.7	0.0
Total zone transitions, hab. session 2	5.1	6.6	9.8	-3.1	2.9	-2.9	-2.8	-2.8	-2.9	-1.3	0.0
Total locomotion distance, hab. session 2	4.4	5.8	11.1	-3.3	2.6	-2.7	-2.3	-2.3	-2.5	-2.1	0.0
Locomotion velocity, hab. session 2	5.1	6.9	12.3	-3.5	2.9	-2.9	-2.7	-2.7	-2.8	-1.6	0.0
Novel to familiar place preference ratio	0.5	0.5	2.3	0.0	0.5	-0.4	-0.8	-0.7	-0.5	1.5	0.0
Novelty place preference	0.5	0.6	3.4	0.1	0.4	-0.3	-0.6	-0.6	-0.4	1.8	0.0
Time in novel zone, NPP test	0.5	0.5	3.5	0.4	0.2	-0.1	-0.4	-0.4	-0.2	1.9	0.0
Total zone transitions, NPP test	2.1	3.0	5.0	-2.2	1.8	-1.8	-1.7	-1.7	-1.8	-1.9	0.0
Total locomotion distance, NPP test	2.7	3.7	6.3	-2.5	2.1	-2.1	-2.0	-2.0	-2.1	-1.4	0.0
Locomotion velocity, NPP test	2.4	3.3	5.9	-2.4	2.0	-2.0	-1.9	-1.8	-1.9	-1.4	0.0
Intraocular pressure	0.6	0.8	1.6	0.5	-1.1	1.1	1.0	1.0	1.3	0.6	0.0
Delta distance traveled before/after self-admin	0.4	0.4	2.8	0.3	-0.0	0.2	-0.2	-0.2	0.1	1.7	0.0
Delta ambulatory time before/after self-admin	0.3	0.3	2.2	0.1	0.2	-0.0	-0.4	-0.4	-0.1	1.5	0.0
Parametrial fat weight	3.1	7.3	10.4	3.2	-2.9	3.0	2.7	2.7	3.0	2.6	0.0
Pavlov. Cond. lever latency	0.9	1.2	6.6	0.9	-0.7	0.8	0.5	0.5	0.8	2.6	0.0
Pavlov. Cond. magazine entry latency	4.1	5.2	8.8	-3.0	2.4	-2.4	-2.2	-2.1	-2.3	-2.7	0.0
Pavlov. Cond. change in total contacts	1.3	1.4	5.3	-1.4	0.9	-1.1	-0.7	-0.7	-0.9	-2.3	0.0
Pavlov. Cond. index score	3.2	4.0	10.2	-2.4	1.9	-2.0	-1.6	-1.6	-1.9	-3.2	0.0
Pavlov. Cond. latency score	2.8	3.5	9.7	-2.1	1.7	-1.8	-1.5	-1.5	-1.8	-3.1	0.0
Pavlov. Cond. lever contacts	0.9	1.1	7.0	-0.8	0.5	-0.7	-0.3	-0.3	-0.6	-2.6	0.0
Pavlov. Cond. magazine entry number	4.5	5.7	10.0	3.2	-2.4	2.5	2.1	2.1	2.3	3.0	0.0
Pavlov. Cond. intertrial magazine entries	2.8	3.4	5.2	2.3	-2.0	2.0	2.1	2.1	2.0	1.0	0.0
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.7	9.5	-2.3	1.8	-1.9	-1.5	-1.5	-1.8	-3.1	0.0
Pavlov. Cond. response bias	3.2	4.0	9.6	-2.5	1.8	-2.0	-1.6	-1.6	-1.8	-3.1	0.0
Pavlov. Cond. lever latency	1.8	2.4	3.6	-1.6	1.8	-1.7	-1.9	-1.9	-1.7	-0.4	0.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.5	-0.7	0.2	-0.2	-0.0	-0.1	-0.1	-0.7	0.0
Pavlov. Cond. change in total contacts	1.6	2.5	4.1	1.4	-1.8	1.8	2.0	2.0	1.9	0.5	0.0
Pavlov. Cond. index score	1.1	1.5	2.6	0.9	-1.4	1.4	1.6	1.6	1.4	-0.2	0.0
Pavlov. Cond. latency score	0.6	0.8	1.4	0.5	-1.0	1.0	1.2	1.2	1.1	-0.1	0.0
Pavlov. Cond. lever contacts	1.8	2.5	3.8	1.7	-1.8	1.8	1.9	1.9	1.8	0.5	0.0
Pavlov. Cond. magazine entry number	0.3	0.4	0.8	-0.4	0.7	-0.7	-0.9	-0.8	-0.7	-0.0	0.0
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	0.3	0.2	-0.2	-0.3	-0.3	-0.3	0.2	0.0
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	2.7	0.9	-1.4	1.4	1.6	1.6	1.5	-0.2	0.0
Pavlov. Cond. response bias	1.9	2.6	4.0	1.7	-1.8	1.8	2.0	1.9	1.8	0.4	0.0
Time in closed arm before self-admin	2.7	3.4	5.6	-1.6	2.1	-2.1	-2.4	-2.3	-2.2	0.7	0.0
Time in closed arm after self-admin	1.5	1.6	2.8	-1.0	1.5	-1.4	-1.7	-1.6	-1.5	0.6	0.0
Time in open arm before self-admin	0.0	0.0	0.3	0.0	0.1	0.0	-0.1	-0.2	-0.0	0.5	0.0
Time in open arm after self-admin	0.3	0.4	2.6	-0.4	0.2	-0.3	-0.0	-0.1	-0.2	-1.6	0.0
Bone: periosteal estimation	0.1	0.2	1.1	1.0	-0.3	0.3	0.3	0.3	0.2	-0.2	0.0
Bone: periosteal perimeter	0.1	0.3	0.9	1.0	-0.4	0.4	0.4	0.4	0.4	0.5	0.0
Bone: post-yield work	0.4	0.5	1.4	1.2	-0.8	0.7	0.8	0.8	0.7	-0.5	0.0
Progressive ratio test 1 active lever presses	1.1	1.3	2.1	1.5	-1.3	1.2	1.2	1.3	1.2	0.6	0.0
Progressive ratio test 1 breakpoint	0.9	1.1	1.7	1.3	-1.2	1.2	1.2	1.2	1.2	0.5	0.0
Progressive ratio test 1 inactive lever presses	0.9	1.2	2.1	1.5	-1.3	1.3	1.1	1.2	1.2	0.6	0.0
Progressive ratio test 2 active lever presses	0.2	0.3	0.5	-0.1	0.6	-0.5	-0.7	-0.7	-0.6	0.7	0.0
Progressive ratio test 2 breakpoint	0.2	0.3	0.5	-0.1	0.5	-0.5	-0.6	-0.6	-0.5	0.7	0.0
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.3	0.3	-0.5	0.5	0.4	0.5	0.6	0.2	0.0
Incentive Sensitization - Responses	2.6	3.6	4.9	-2.0	2.2	-2.2	-2.2	-2.2	-2.2	-0.9	0.0
Incentive Sensitization - Breakpoint	2.3	3.0	4.0	-1.8	2.0	-2.0	-2.0	-2.0	-2.0	-0.9	0.0
Sum of active levers in priming session hrs 5-6	2.2	2.1	3.8	0.7	-1.6	1.6	1.9	1.9	1.7	-0.9	0.0
Progressive ratio	0.3	0.5	0.9	-0.9	0.9	-0.9	-0.7	-0.7	-0.8	-0.2	0.0
Food seeking constrained by brief footshock	0.2	0.2	0.9	-0.4	0.3	-0.3	-0.4	-0.4	-0.3	-0.9	0.0
Seeking ratio, punishment vs. effort	0.2	0.2	0.4	0.5	-0.6	0.6	0.4	0.4	0.6	-0.2	0.0
Retroperitoneal fat weight	0.8	3.3	5.7	2.4	-2.1	2.1	1.9	1.9	2.0	1.0	0.0
Reaction time number correct	0.3	0.5	2.7	0.7	-0.4	0.4	0.4	0.4	0.3	1.6	0.0
Reaction time mean minus median	3.3	8.3	12.0	-3.1	3.0	-3.1	-2.8	-2.8	-3.1	-3.5	0.0
Reaction time mean minus median AUC	2.1	5.4	9.4	-2.7	2.3	-2.5	-2.1	-2.1	-2.4	-3.1	0.0
Reaction time num false alarms	0.4	0.5	3.6	-0.7	0.0	-0.1	0.1	0.2	0.0	-1.9	0.0
Reaction time num false alarms AUC	0.3	0.5	3.2	-0.9	0.1	-0.2	-0.0	0.0	-0.1	-1.8	0.0
Reaction time trials correct on left	0.3	0.5	2.7	0.7	-0.4	0.4	0.4	0.4	0.3	1.6	0.0
Reaction time trials on left	0.2	0.4	2.1	0.7	-0.3	0.3	0.3	0.3	0.2	1.4	0.0
Reaction time mean	1.2	1.9	5.7	-1.9	1.1	-1.2	-1.0	-1.0	-1.1	-2.4	0.0
Reaction time mean AUC	1.2	1.9	6.0	-1.8	1.1	-1.2	-0.9	-0.9	-1.1	-2.5	0.0
Median of all reaction times	0.4	0.5	2.6	-1.1	0.3	-0.3	-0.1	-0.1	-0.1	-1.6	0.0
Reaction time omissions	2.7	3.9	9.3	-2.1	1.9	-2.0	-1.7	-1.7	-1.9	-3.1	0.0
Reaction time false alarm rate	0.4	0.6	3.6	-0.9	0.1	-0.2	-0.0	0.0	0.0	-1.9	0.0
Reaction time premature initiation rate	0.2	0.3	0.5	0.6	-0.6	0.6	0.7	0.6	0.6	0.2	0.0
Reaction time premature initiations	0.3	0.5	0.8	0.9	-0.7	0.7	0.8	0.8	0.7	0.8	0.0
Std. dev. reaction times	2.8	5.3	8.5	-2.6	2.3	-2.4	-2.2	-2.2	-2.4	-2.9	0.0
Reaction time trials completed	0.2	0.4	2.1	0.7	-0.3	0.3	0.3	0.3	0.2	1.4	0.0
Reaction time trials AUC	0.3	0.5	1.9	0.8	-0.5	0.5	0.6	0.5	0.4	1.4	0.0
Run reversals in cocaine runway, females	0.9	0.9	1.4	-0.8	1.1	-1.0	-1.2	-1.2	-1.1	-0.2	0.0
Run reversals in cocaine runway, males	0.1	0.1	0.4	0.2	0.2	-0.2	-0.3	-0.4	-0.2	0.6	0.0
Latency to leave start box in cocaine runway	0.2	0.2	0.6	-0.8	0.3	-0.4	-0.2	-0.2	-0.3	-0.8	0.0
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.3	0.2	-0.2	-0.1	-0.2	-0.3	0.1	0.0
Latency to leave start box in cocaine runway, M	0.4	0.3	2.3	-0.7	0.1	-0.1	0.1	0.1	-0.0	-1.5	0.0
Std. dev. time between licks in bursts	0.0	0.0	0.3	0.5	-0.1	0.1	-0.0	0.0	-0.1	0.1	0.0
Total sessions with >9 infusions	1.3	1.5	2.4	1.5	-1.4	1.3	1.4	1.4	1.3	0.8	0.0
Short access day 1 total inactive lever presses	5.3	6.9	9.4	3.1	-3.0	3.0	2.8	2.8	3.1	1.5	0.0
Short access day 10 total inactive lever presses	0.0	0.1	0.2	-0.3	0.3	-0.2	-0.5	-0.5	-0.2	0.0	0.0
Short access day 1 total infusions	3.7	4.9	7.7	2.8	-2.5	2.5	2.3	2.4	2.5	1.4	0.0
Short access day 10 total infusions	0.3	0.4	1.6	0.6	-0.5	0.5	0.5	0.5	0.5	1.3	0.0
Short access total infusions	1.2	1.6	3.4	1.6	-1.2	1.3	1.1	1.1	1.2	1.8	0.0
Short access day 1 locomotion	1.1	1.4	1.8	1.2	-1.2	1.3	1.2	1.2	1.3	1.3	0.0
Short access day 10 total locomotion	0.1	0.1	0.6	0.1	-0.3	0.2	0.4	0.4	0.2	-0.8	0.0
Short access total locomotion	0.4	0.5	0.7	0.8	-0.8	0.8	0.8	0.8	0.8	0.6	0.0
One hour access (0.3 mA shock)	1.9	2.2	3.3	1.7	-1.7	1.6	1.8	1.8	1.7	0.7	0.0
Compulsive drug intake	0.3	0.3	2.2	-0.4	0.1	-0.2	0.0	-0.0	-0.2	-1.5	0.0
One hour access (shock baseline)	0.5	0.8	1.9	0.9	-0.9	0.9	0.8	0.9	0.9	1.4	0.0
Social response proportion	0.1	0.1	0.3	0.1	-0.4	0.5	0.3	0.3	0.5	0.5	0.0
Social responses	0.2	0.3	1.9	-0.1	-0.1	0.2	0.1	0.1	0.3	1.4	0.0
Social time	2.1	2.9	4.3	1.5	-1.9	2.0	1.8	1.9	2.1	1.6	0.0
Soleus weight	0.7	2.2	3.9	2.0	-1.7	1.6	1.7	1.7	1.5	-0.4	0.0
Bone: stiffness	0.2	0.3	0.5	0.2	0.5	-0.5	-0.6	-0.6	-0.7	-0.6	0.0
Tibialis anterior weight	6.8	22.9	36.5	6.0	-5.4	5.3	5.3	5.3	5.2	2.2	0.0
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.5	-1.2	1.1	-1.1	-0.9	-1.0	-1.1	-0.1	0.0
Time to tail flick, vehicle, after self-admin	0.9	1.2	2.4	-0.6	1.2	-1.2	-1.6	-1.5	-1.3	0.5	0.0
Time to tail flick, test, before self-admin	0.1	0.1	0.4	-0.6	-0.2	0.2	0.3	0.3	0.3	-0.4	0.0
Time to tail flick, test, after self-admin	1.4	1.5	2.4	1.3	-1.3	1.4	1.1	1.1	1.4	1.5	0.0
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	-0.1	0.5	-0.3	-0.8	-0.7	-0.5	0.6	0.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.4	0.7	-0.2	0.2	0.1	0.1	0.2	0.5	0.0
Tibia length	0.8	2.2	3.3	1.4	-1.7	1.5	1.8	1.8	1.5	-1.4	0.0
Ambulatory time before self-admin	0.3	0.4	3.0	0.2	-0.1	-0.1	0.3	0.2	-0.1	-1.7	0.0
Ambulatory time after self-admin	0.2	0.2	0.4	0.6	-0.5	0.5	0.5	0.5	0.4	0.1	0.0
Bone: tissue strength	0.2	0.2	0.8	0.9	-0.5	0.5	0.4	0.4	0.4	0.3	0.0
Total heroin consumption	2.5	2.9	4.9	1.2	-2.0	1.9	2.2	2.2	2.0	-0.8	0.0
Bone: trabecular number	4.9	8.2	15.1	3.9	-3.2	3.2	3.1	3.1	3.1	1.2	0.0
Bone: trabecular spacing	5.3	7.0	10.8	-3.3	2.9	-2.9	-2.9	-2.9	-2.9	-1.8	0.0
Bone: trabecular thickness	3.6	4.5	7.1	2.7	-2.4	2.4	2.4	2.4	2.3	0.8	0.0
Bone: trabecular tissue density	1.7	2.5	3.3	-1.5	1.7	-1.8	-1.6	-1.6	-1.8	-1.8	0.0
Water consumed over 24 hours	0.7	1.0	1.6	0.8	-1.1	1.1	1.2	1.3	1.2	0.2	0.0
Number of responses in last shaping day	0.4	0.5	0.7	0.4	-0.8	0.7	0.8	0.9	0.8	-0.6	0.0