Hub : Genes

Prkca

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Prkca 0.32 0.11 1.1e-13 0.28 0.31 0.3 0.27 5.1e-12 9.5e-14 6.6e-13 5.9e-12
2 PL gene expression Prkca 0.03 0.02 3.1e-03 0.03 0.02 0.02 0.02 5.9e-04 2.3e-03 1.8e-03 1.4e-03
3 pVTA gene expression Prkca 0.07 0.04 1.1e-04 0.03 0.05 0.04 0.03 1.5e-03 5.9e-05 1.7e-04 2.7e-03
4 pVTA mRNA stability Prkca 0.06 0.04 5.9e-04 0.04 0.03 0.04 0.02 4.2e-04 1.9e-03 4.6e-04 1.6e-02
5 Adipose gene expression Prkca 0.31 0.14 1.0e-13 0.08 0.09 0.09 0.09 4.8e-09 3.0e-10 1.6e-10 6.3e-10
6 Brain gene expression Prkca 0.15 0.07 9.1e-13 0.07 0.1 0.13 0.05 2.9e-07 1.6e-09 6.3e-12 1.4e-05
7 OFC gene expression Prkca 0.23 0.11 5.8e-04 0.05 0.09 0.14 0.06 2.9e-02 3.9e-03 3.7e-04 1.5e-02
8 Liver gene expression Prkca 0.8 0.12 0.0e+00 0.18 0.28 0.29 0.28 1.3e-19 1.1e-31 4.6e-32 1.1e-31
9 NAcc gene expression Prkca 0.02 0.02 7.7e-03 0.01 0.02 0.02 0.01 2.9e-03 1.4e-03 4.2e-04 6.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.30.51.80.40.20.0-0.6-0.10.80.61.1-1.3
Area under the delay curve0.20.20.60.1-0.10.60.80.6-0.40.40.20.5
BMI with tail2.79.325.2-3.8-2.9-3.0-0.41.7-5.0-3.0-3.61.2
BMI without tail3.711.227.2-4.2-2.8-4.0-1.21.4-5.2-3.6-3.90.0
Body weight5.624.554.8-6.7-5.8-5.0-2.45.1-7.4-5.3-1.50.7
Weight adjusted by age1.01.67.4-0.0-0.31.31.70.8-0.80.4-0.72.7
Bone surface1.62.97.8-0.9-1.2-1.5-2.81.30.50.12.6-2.4
Bone volume1.22.14.6-1.0-1.5-1.2-2.11.6-0.2-0.12.2-1.7
Breakpoint value in progressive ratio session1.92.26.01.21.50.81.3-1.40.51.9-2.41.5
Number of licking bursts0.30.51.3-0.7-1.1-0.1-0.21.2-0.5-0.60.40.6
Context. condit. distance diff. score0.20.31.0-0.4-0.50.10.50.4-0.6-0.5-0.31.0
Locomotion velocity, session 10.10.10.2-0.1-0.0-0.4-0.5-0.10.10.30.4-0.1
Locomotion distance, session 10.00.00.30.00.2-0.1-0.0-0.30.10.5-0.00.1
Locomotion velocity, session 20.91.12.40.71.1-0.6-1.1-1.31.50.70.0-1.3
Locomotion distance, session 20.60.81.90.81.3-0.2-0.3-1.41.00.9-0.5-0.8
Locomotion velocity, session 31.01.12.31.01.31.01.5-1.30.40.4-1.10.9
Locomotion distance, session 30.20.20.50.20.10.70.50.30.2-0.30.50.7
Stereotopy head waving bouts, day 34.65.38.92.92.92.11.9-3.02.42.6-1.00.1
Stereotopy head waving duration, day 32.83.45.42.32.22.01.8-2.01.82.3-0.70.5
Locomotion velocity, session 70.30.30.50.50.60.50.7-0.50.20.6-0.70.4
Locomotion distance, session 70.30.40.9-0.6-0.8-0.2-0.20.9-0.6-1.00.30.1
Stereotopy head waving bouts, day 72.52.85.32.12.31.61.6-2.01.71.3-1.10.8
Stereotopy head waving duration, day 73.94.78.12.82.82.21.9-2.52.52.1-0.80.7
Locomotion velocity, session 80.10.10.30.1-0.10.0-0.40.20.40.30.60.3
Locomotion distance, session 80.10.10.3-0.00.3-0.5-0.4-0.60.30.1-0.1-0.3
Degree of sensitization distance0.20.20.4-0.5-0.5-0.7-0.60.4-0.3-0.30.0-0.6
Degree of sensitization stereotypy1.21.32.41.11.50.81.1-1.40.80.4-1.41.1
Conditioned locomotion0.20.20.60.60.80.2-0.1-0.30.60.6-0.5-0.3
Cocaine response after cond. corrected0.40.51.4-0.2-0.60.60.41.1-0.2-0.90.81.2
Cocaine response after cond. not corrected0.70.82.7-0.1-0.60.80.41.20.2-0.91.01.6
Cocaine response before conditioning0.20.20.60.40.30.60.1-0.00.80.60.50.5
Saline control response1.82.45.1-1.7-0.7-2.1-0.8-0.2-2.1-1.7-2.30.0
Bone: connectivity density1.52.46.21.41.5-0.1-1.0-1.52.11.60.9-2.5
Bone: cortical apparent density3.34.58.12.22.62.02.8-2.60.91.2-2.61.0
Bone: cortical area0.60.92.1-1.1-0.9-1.4-1.20.4-1.1-0.8-0.7-0.7
Bone: cortical porosity1.92.06.4-1.4-1.4-1.7-2.51.4-0.1-0.41.3-1.1
Bone: cortical porosity2.32.54.7-2.0-1.9-1.8-2.21.9-1.1-0.80.9-0.4
Bone: cortical thickness3.15.218.91.32.11.12.9-2.9-0.50.3-4.31.8
Bone: cortical thickness2.42.810.21.21.80.21.1-2.80.30.6-3.20.3
Bone: cortical tissue density3.24.47.92.22.61.92.8-2.60.91.2-2.61.0
Condit. Reinf. active minus inactive responses2.93.25.8-2.1-2.4-1.7-2.02.3-1.3-1.21.6-0.7
Condit. Reinf. active-inactive response ratio0.91.02.7-0.9-1.3-0.5-1.11.6-0.3-0.21.4-0.3
Condit. Reinf. active responses2.63.24.9-2.1-2.2-2.0-2.21.8-1.2-1.51.5-1.4
Condit. Reinf. inactive responses0.70.92.0-0.9-0.6-1.3-1.1-0.1-0.6-1.00.6-1.4
Incentive salience index mean1.41.72.9-1.6-1.6-1.5-1.71.4-1.0-1.00.7-0.9
Condit. Reinf. lever presses0.10.20.6-0.4-0.1-0.6-0.3-0.1-0.4-0.5-0.8-0.4
Condit. Reinf. active minus inactive responses3.14.08.9-1.8-1.9-2.2-3.01.9-0.4-1.72.1-1.9
Condit. Reinf. active-inactive response ratio2.42.85.0-1.6-1.8-1.4-2.22.1-0.4-1.51.9-1.1
Condit. Reinf. active responses3.65.011.8-2.2-2.2-2.7-3.41.9-0.6-1.82.0-2.3
Condit. Reinf. inactive responses0.91.23.4-0.7-0.2-1.8-1.9-0.5-0.0-0.20.1-1.8
Condit. Reinf. lever presses2.83.99.1-2.2-2.0-2.8-3.01.1-1.1-1.70.6-1.9
Condit. Reinf. lever reinforcers received3.75.111.7-2.2-2.2-2.8-3.41.9-0.7-1.82.0-2.3
Conditioned reinforcement - actives0.40.61.8-0.6-0.8-0.7-1.30.6-0.10.00.5-1.3
Conditioned reinforcement - inactives1.01.52.9-1.6-1.7-0.9-0.91.6-1.6-0.90.40.2
Conditioned locomotion2.43.14.8-2.1-2.2-1.9-1.91.9-1.9-1.90.3-0.6
Patch foraging indifference point 0 sec4.17.614.5-3.3-2.8-3.8-3.11.7-2.9-3.20.5-2.0
Patch foraging indifference point AUC0.40.51.1-1.0-0.9-0.9-0.60.7-0.8-0.7-0.0-0.1
Delay disc. indifference point, 0s delay0.50.51.30.50.31.21.10.20.21.10.00.9
Delay disc. indifference point, 16s delay0.10.10.6-0.4-0.2-0.10.30.3-0.8-0.0-0.00.1
Delay disc. indifference point, 2s delay0.30.31.40.40.30.30.00.30.30.31.2-0.7
Delay disc. indifference point, 24s delay1.01.13.1-1.3-1.2-1.1-0.41.0-1.8-1.1-0.2-0.3
Delay disc. indifference point, 4s delay0.60.71.90.80.51.21.00.10.51.40.40.6
Delay disc. indifference point, 8s delay0.60.72.60.60.51.11.60.0-0.30.6-0.61.1
Indifference point function ln k0.71.22.41.51.40.90.6-1.51.40.8-0.9-0.1
Indifference point function log k0.71.22.41.51.40.90.6-1.51.40.8-0.9-0.1
Patch foraging total patch changes 0 sec3.87.214.2-3.1-2.6-3.8-3.11.5-2.7-3.20.6-2.2
Patch foraging total patch changes 12 sec3.64.69.3-2.6-2.0-3.0-2.71.6-1.8-2.01.1-1.8
Patch foraging total patch changes 18 sec1.72.55.2-2.2-1.7-2.3-1.41.0-1.9-1.9-0.1-0.6
Patch foraging total patch changes 24 sec2.03.35.8-2.4-2.1-2.4-1.81.7-2.0-1.90.6-0.7
Patch foraging total patch changes 6 sec5.88.914.5-3.7-3.3-3.6-2.92.6-3.3-3.80.6-1.0
Patch foraging time to switch 0 sec0.10.30.9-0.1-0.30.40.70.5-0.5-0.40.40.9
Patch foraging water rate 0 sec0.71.53.4-1.1-0.7-1.8-1.90.2-0.6-1.3-0.2-1.7
Patch foraging water rate 12 sec0.10.20.8-0.4-0.4-0.20.00.2-0.7-0.3-0.90.7
Patch foraging water rate 18 sec0.20.41.30.50.7-0.3-0.1-1.20.3-0.2-0.8-0.5
Patch foraging water rate 24 sec0.50.71.21.11.00.90.6-1.01.10.80.0-0.2
Patch foraging water rate 6 sec0.81.12.81.11.50.30.5-1.70.80.4-1.6-0.6
Seeking ratio, delayed vs. immediate footshock0.30.41.2-0.7-0.80.10.70.8-1.1-0.3-0.20.4
Distance traveled before self-admin1.21.52.71.61.61.31.1-1.11.51.30.9-0.0
Distance traveled after self-admin0.40.41.90.50.9-0.1-0.3-0.20.80.21.4-0.2
Extensor digitorum longus weight0.83.37.1-0.9-0.81.02.41.1-2.6-0.2-2.52.7
Bone: elastic displacement1.21.43.21.31.51.01.3-1.80.91.0-0.90.7
Bone: elastic work0.30.41.7-0.20.2-0.60.0-0.8-0.7-0.3-1.3-0.0
Bone: endosteal estimation10.422.746.6-4.8-5.6-4.7-6.85.8-2.1-2.74.9-3.3
Bone: endosteal perimeter9.620.435.5-4.6-5.5-4.1-6.05.9-2.2-2.65.1-2.8
Epididymis fat weight2.48.323.0-3.9-3.4-2.4-0.42.8-4.8-2.7-1.31.4
Delta time in closed arm before/after self-admin0.40.30.80.70.40.90.40.10.70.40.8-0.0
Delta time in open arm before/after self-admin0.60.61.01.00.80.80.8-0.90.91.00.1-0.3
Diff in mean of infusions in LGA sessions1.41.77.40.50.70.61.4-1.0-0.41.0-2.71.5
Delay discount exponential model param0.20.20.70.10.4-0.4-0.5-0.80.6-0.2-0.4-0.5
Extinction: sum of active levers before priming0.50.51.50.10.20.50.80.2-0.50.8-1.21.2
Active lever presses in extinction session 60.40.41.2-0.20.5-1.1-0.8-0.5-0.20.5-0.1-0.8
Bone: final force0.50.82.0-0.7-0.6-1.2-1.40.4-0.4-0.80.4-1.4
Bone: final moment0.60.92.6-0.6-0.6-1.2-1.50.3-0.3-0.80.5-1.6
Food consumed during 24 hour testing period1.41.95.5-1.00.0-2.3-1.2-1.1-1.4-0.7-2.0-1.4
Glucose1.11.75.50.50.01.71.90.7-0.31.4-0.82.3
Heart weight0.81.33.2-1.1-1.20.10.61.8-1.8-0.5-0.21.5
Delay discount hyperbolic model param0.20.20.60.00.3-0.6-0.6-0.80.5-0.3-0.4-0.5
Intermittent access intake day 1-15 change1.73.49.3-2.2-2.7-0.8-0.93.1-1.9-1.20.31.6
Intermittent access intake escalation1.63.38.0-2.3-2.6-1.0-1.02.8-1.9-1.40.21.3
Intermittent access intake escalation 22.73.16.9-2.2-2.6-1.2-1.42.5-1.5-1.71.10.4
Intermitt. access day 1 inactive lever presses0.72.84.7-2.2-1.9-1.5-1.12.0-2.1-1.5-0.61.4
Intermitt. access day 15 inactive lever presses0.91.94.1-1.9-1.8-1.2-0.71.6-2.0-0.9-0.70.7
Intermitt. access escalation Index0.40.51.01.00.80.70.4-0.80.90.9-0.10.3
Intermittent access day 1 total infusions0.20.30.8-0.8-0.6-0.9-0.90.1-0.6-0.2-0.1-0.3
Intermittent access day 15 total infusions2.63.87.6-2.7-2.8-1.9-1.72.4-2.3-1.4-0.00.3
Intermittent access terminal intake (last 3 days)3.85.09.4-2.9-3.1-2.3-2.52.5-2.1-1.91.2-0.8
Intermittent access total infusions2.42.95.1-2.2-2.3-1.9-2.01.6-1.6-1.50.6-0.9
Intermittent access day 1 locomotion3.54.58.0-2.8-2.4-2.4-1.91.9-2.7-2.3-0.7-0.2
Intermittent access day 15 total locomotion3.56.310.4-3.2-2.9-3.1-2.82.2-2.8-2.6-0.0-1.1
Intermittent access total locomotion8.29.816.7-4.1-3.7-3.8-3.32.7-3.7-3.2-0.2-1.2
Intermittent access standard deviation2.85.815.9-2.8-3.5-0.8-0.94.0-2.7-2.01.11.3
Left kidney weight0.21.02.7-1.1-0.9-0.7-0.00.7-1.6-0.5-1.50.9
Right kidney weight0.31.54.6-1.3-1.1-0.90.10.8-2.2-0.6-1.71.0
Cocaine induced anxiety0.30.41.20.60.10.70.1-0.11.11.10.80.0
Post-drug Anxiety1.21.32.31.40.91.51.2-0.71.41.50.10.4
Baseline Anxiety1.11.22.51.31.50.81.2-1.60.70.7-1.30.2
Tail length1.76.512.5-3.2-2.5-3.5-3.01.9-2.7-2.60.2-1.8
Length with tail2.711.621.7-4.3-4.2-3.0-2.74.7-3.9-3.32.1-0.3
Length without tail1.65.113.0-2.6-2.9-0.9-0.53.6-2.9-2.21.21.2
Times rat made contact with spout0.70.81.8-1.2-1.1-1.3-1.20.4-0.7-0.60.2-0.0
Lifetime Intake1.82.23.5-1.9-1.8-1.8-1.81.1-1.6-1.40.1-0.8
Liver weight, left1.42.34.9-1.8-1.8-1.9-2.21.5-0.8-1.21.1-0.9
Liver weight, right0.40.74.4-0.20.1-0.30.4-0.4-0.60.1-2.10.8
Locomotor activity1.62.46.8-1.9-1.1-2.6-1.80.5-1.6-1.4-1.1-1.0
Locomotor testing distance0.91.54.7-1.5-0.7-2.2-1.50.1-1.2-0.9-1.1-0.9
Locomotor testing rearing0.81.64.2-1.5-0.6-2.1-1.5-0.3-1.2-0.5-1.9-0.5
Locomotion in novel chamber0.70.81.90.90.91.01.0-0.30.61.4-0.21.1
Locomotion in novel chamber post-restriction0.40.73.3-0.3-0.3-0.4-0.50.20.0-0.91.8-1.2
Fecal boli incidents, locomotor time 10.60.92.3-0.2-1.01.00.41.5-0.21.30.91.0
Change in fecal boli incidents, locomotor task0.70.72.50.50.8-0.3-0.5-0.70.7-0.31.0-1.6
Time >=10cm from walls, locomotor time 10.60.61.80.80.61.31.0-0.11.00.60.50.6
Bouts of movement, locomotor time 10.70.82.3-0.7-0.7-0.20.50.5-1.3-0.7-1.51.1
Total resting periods, locomotor time 10.60.71.5-0.6-0.70.10.60.7-1.2-0.3-1.21.2
Rest time, locomotor task time 10.70.82.40.5-0.11.41.10.50.21.0-0.51.5
Distance moved, locomotor task time 10.40.61.6-0.30.5-0.9-0.2-0.9-0.5-1.1-0.8-1.3
Vertical activity count, locomotor time 10.20.41.8-0.30.1-0.7-0.2-0.4-0.3-1.3-0.2-1.0
Time >=10cm from walls, locomotor time 20.71.15.90.41.00.10.6-0.80.30.7-2.41.0
Bouts of movement, locomotor time 21.01.66.1-0.8-0.2-0.31.2-0.4-1.9-0.7-2.51.3
Total resting periods, locomotor time 20.81.44.1-0.7-0.30.01.4-0.0-1.8-0.7-2.01.5
Rest time, locomotor task time 23.94.914.32.51.43.82.9-0.51.82.50.51.7
Distance moved, locomotor task time 21.31.67.0-0.60.6-1.8-0.8-1.2-0.7-0.7-2.6-0.7
Vertical activity count, locomotor time 22.23.08.7-1.7-0.7-2.9-2.0-0.2-1.3-1.9-2.0-1.0
Light reinforcement 10.71.88.20.31.3-0.50.9-1.9-0.7-0.7-2.9-0.6
Light reinforcement 20.50.82.80.50.61.01.7-0.2-0.5-0.7-1.30.6
Bone: marrow area10.021.845.2-4.7-5.5-4.6-6.75.7-2.0-2.74.8-3.2
Bone: maximum diameter2.54.79.6-1.8-2.3-1.8-3.12.8-0.6-0.92.8-2.0
Bone: maximum force1.22.23.4-1.6-1.7-1.6-1.81.4-1.2-1.50.8-1.3
Bone: maximum moment1.32.23.8-1.5-1.7-1.7-2.01.3-1.1-1.50.9-1.5
Mean time between licks in bursts1.02.56.4-2.0-2.2-0.7-0.12.1-2.5-1.40.40.8
Mean num. licks in bursts0.10.20.90.10.5-0.4-0.2-0.9-0.00.2-0.5-0.4
Cd content in liver0.80.92.40.80.31.61.20.40.70.51.50.6
Co content in liver0.50.62.80.30.01.31.70.3-0.2-0.10.20.9
Cu content in liver0.10.10.3-0.1-0.2-0.1-0.30.50.1-0.40.4-0.5
Fe content in liver0.20.20.7-0.0-0.1-0.3-0.70.10.4-0.70.9-0.4
K content in liver0.70.61.61.10.70.80.3-0.71.30.20.8-0.6
Mg content in liver2.02.04.12.01.91.10.6-1.92.00.90.3-1.0
Mn content in liver2.62.96.22.12.30.6-0.3-2.02.51.70.7-1.6
Na content in liver0.70.81.51.10.81.10.6-0.61.20.90.6-0.6
Rb content in liver1.11.32.81.51.21.30.6-0.81.71.00.9-0.3
Se content in liver1.51.83.31.51.31.81.8-1.01.11.1-0.21.4
Sr content in liver0.60.51.2-0.9-0.7-0.5-0.00.6-1.1-0.1-0.90.8
Zn content in liver0.40.51.70.70.21.31.0-0.10.80.10.60.5
Bone: minimum diameter8.215.025.2-4.3-4.8-4.1-5.04.6-2.7-2.93.1-2.3
Time in familiar zone, hab. session 11.51.43.4-1.3-1.7-0.9-1.21.8-0.9-0.81.1-0.2
Time in novel zone, hab. session 11.01.02.31.01.30.40.7-1.50.70.4-1.50.1
Total zone transitions, hab. session 10.40.61.4-0.8-0.3-1.2-0.50.0-1.1-0.2-1.1-0.4
Total locomotion distance, hab. session 10.81.13.1-0.60.3-1.8-1.1-1.0-0.7-0.3-1.1-1.5
Locomotion velocity, hab. session 10.60.92.5-0.50.4-1.6-1.0-0.9-0.6-0.1-0.9-1.5
Time in familiar zone, hab. session 21.11.11.7-1.2-1.3-1.0-1.31.3-0.7-1.30.7-0.1
Time in novel zone, hab. session 21.81.83.61.71.80.90.9-1.91.41.5-0.4-0.7
Total zone transitions, hab. session 20.40.52.8-0.40.4-0.8-0.0-0.6-0.7-0.2-1.70.3
Total locomotion distance, hab. session 20.81.02.8-0.30.9-1.5-0.4-1.4-0.5-0.1-1.7-0.9
Locomotion velocity, hab. session 20.81.02.90.11.2-1.1-0.2-1.7-0.20.1-1.7-0.9
Novel to familiar place preference ratio2.32.54.6-1.8-2.2-1.3-1.42.1-1.5-1.81.2-0.4
Novelty place preference1.61.83.2-1.5-1.8-1.0-1.21.8-1.2-1.51.0-0.3
Time in novel zone, NPP test1.41.52.6-1.4-1.6-1.0-1.11.5-1.1-1.51.0-0.3
Total zone transitions, NPP test0.60.92.70.41.3-0.50.1-1.50.10.4-1.6-0.5
Total locomotion distance, NPP test1.41.95.10.41.6-1.5-1.0-2.30.50.2-1.2-2.1
Locomotion velocity, NPP test0.81.23.40.21.4-1.2-0.3-1.9-0.0-0.0-1.4-1.4
Intraocular pressure0.10.20.5-0.6-0.4-0.5-0.20.4-0.7-0.1-0.30.1
Delta distance traveled before/after self-admin0.40.41.6-0.6-0.0-1.3-1.1-0.2-0.2-0.5-0.2-0.5
Delta ambulatory time before/after self-admin0.60.82.6-0.8-0.4-1.6-1.60.4-0.2-0.60.5-0.7
Parametrial fat weight0.40.92.20.90.70.5-0.2-0.31.10.91.5-1.4
Pavlov. Cond. lever latency1.31.73.21.61.11.50.7-0.91.71.81.2-0.2
Pavlov. Cond. magazine entry latency1.51.93.2-1.6-1.4-1.8-1.61.1-1.2-1.70.4-0.9
Pavlov. Cond. change in total contacts1.92.03.7-1.8-1.5-1.9-1.51.1-1.5-1.8-0.5-0.4
Pavlov. Cond. index score1.62.03.8-1.8-1.5-1.8-1.31.2-1.5-1.9-0.2-0.5
Pavlov. Cond. latency score1.62.14.3-1.8-1.5-1.6-1.01.3-1.7-2.1-0.4-0.0
Pavlov. Cond. lever contacts1.31.63.3-1.5-1.1-1.4-0.61.0-1.7-1.8-1.00.3
Pavlov. Cond. magazine entry number1.11.42.21.41.31.41.3-1.11.11.5-0.60.6
Pavlov. Cond. intertrial magazine entries2.12.55.0-2.0-2.2-1.3-1.31.8-1.8-1.51.2-0.6
Pavlov. Cond. lever-magazine prob. diff.1.31.62.9-1.6-1.3-1.7-1.31.0-1.4-1.7-0.2-0.6
Pavlov. Cond. response bias1.11.42.8-1.3-1.0-1.7-1.60.9-0.9-1.30.3-1.1
Pavlov. Cond. lever latency0.50.72.10.60.80.91.5-0.3-0.20.2-1.00.9
Pavlov. Cond. magazine entry latency0.70.92.30.4-0.21.51.40.50.20.80.41.5
Pavlov. Cond. change in total contacts0.30.41.4-0.3-0.6-0.5-1.00.60.4-0.11.2-0.5
Pavlov. Cond. index score0.30.51.3-0.6-1.0-0.3-0.71.00.00.11.1-0.0
Pavlov. Cond. latency score0.30.41.6-0.4-0.90.0-0.51.00.20.31.30.1
Pavlov. Cond. lever contacts0.40.51.7-0.5-0.6-0.9-1.3-0.00.2-0.10.6-0.9
Pavlov. Cond. magazine entry number0.91.13.1-0.6-0.1-1.7-1.7-0.3-0.3-0.8-0.3-1.8
Pavlov. Cond. intertrial magazine entries2.74.010.5-1.4-0.6-3.2-3.1-0.2-0.8-1.8-0.0-3.1
Pavlov. Cond. lever-magazine prob. diff.0.30.41.5-0.5-0.9-0.1-0.60.90.10.21.20.1
Pavlov. Cond. response bias0.20.20.7-0.4-0.6-0.5-0.80.20.2-0.10.7-0.4
Time in closed arm before self-admin0.81.03.5-0.60.3-1.9-1.1-0.8-0.6-0.5-1.4-0.6
Time in closed arm after self-admin0.10.10.5-0.40.1-0.7-0.30.1-0.4-0.1-0.30.1
Time in open arm before self-admin1.61.84.1-1.1-1.80.91.21.7-1.5-0.40.32.0
Time in open arm after self-admin0.60.61.4-0.1-0.81.21.10.9-0.4-0.10.80.9
Bone: periosteal estimation6.313.328.1-3.9-4.4-4.0-5.34.1-2.0-2.22.9-2.7
Bone: periosteal perimeter3.96.715.4-2.9-3.5-1.9-2.83.9-1.8-1.72.5-0.7
Bone: post-yield work2.43.57.5-2.3-2.7-1.5-1.72.5-1.8-1.71.2-0.3
Progressive ratio test 1 active lever presses3.03.78.1-2.4-1.9-2.9-2.30.8-2.3-1.5-0.6-1.4
Progressive ratio test 1 breakpoint3.13.88.8-2.4-1.8-3.0-2.40.7-2.2-1.5-0.7-1.6
Progressive ratio test 1 inactive lever presses3.44.98.9-2.9-2.4-3.0-2.51.7-2.7-2.1-0.5-0.6
Progressive ratio test 2 active lever presses1.21.42.3-1.4-1.2-1.5-1.50.9-1.2-1.10.5-0.8
Progressive ratio test 2 breakpoint1.31.52.6-1.4-1.2-1.6-1.60.9-1.2-1.20.6-1.0
Progressive ratio test 2 inactive lever presses1.01.63.3-1.7-1.5-1.5-1.01.0-1.8-1.0-0.3-0.6
Incentive Sensitization - Responses0.10.10.70.2-0.00.50.10.30.40.20.8-0.0
Incentive Sensitization - Breakpoint0.10.20.90.3-0.10.50.10.30.50.20.9-0.0
Sum of active levers in priming session hrs 5-60.80.72.40.60.90.40.6-0.40.11.6-1.11.1
Progressive ratio0.71.02.20.2-0.01.41.31.2-0.10.61.51.2
Food seeking constrained by brief footshock1.41.85.2-0.9-0.4-1.7-2.30.50.1-0.41.6-2.0
Seeking ratio, punishment vs. effort1.21.85.3-0.7-0.3-2.2-2.3-0.8-0.0-0.7-0.3-2.1
Retroperitoneal fat weight1.46.116.6-3.3-2.5-2.4-0.41.9-4.1-2.6-1.91.0
Reaction time number correct0.61.22.01.41.31.30.8-0.71.41.40.3-0.1
Reaction time mean minus median0.00.10.3-0.0-0.20.40.30.3-0.20.6-0.10.2
Reaction time mean minus median AUC0.10.40.90.70.40.6-0.0-0.20.70.90.6-0.6
Reaction time num false alarms1.72.44.1-2.0-2.0-1.9-1.71.5-1.6-1.40.2-0.4
Reaction time num false alarms AUC1.82.84.6-2.1-2.1-2.1-2.11.5-1.5-1.60.4-0.6
Reaction time trials correct on left0.61.22.01.41.31.30.8-0.71.41.40.3-0.1
Reaction time trials on left0.61.11.91.41.31.20.7-0.71.31.40.3-0.2
Reaction time mean0.40.61.70.80.40.80.2-0.41.01.30.8-0.2
Reaction time mean AUC0.40.61.90.90.50.80.2-0.71.01.40.4-0.1
Median of all reaction times0.50.82.01.00.60.80.2-0.71.31.40.8-0.4
Reaction time omissions0.40.50.9-0.7-0.6-1.0-0.90.3-0.8-0.70.3-0.9
Reaction time false alarm rate2.63.66.2-2.4-2.5-2.3-2.11.7-1.9-1.90.2-0.2
Reaction time premature initiation rate1.31.83.2-1.7-1.7-1.1-0.61.2-1.8-1.5-0.81.1
Reaction time premature initiations0.20.30.5-0.6-0.7-0.3-0.20.5-0.7-0.5-0.60.7
Std. dev. reaction times0.10.20.90.3-0.00.4-0.20.20.50.80.9-0.1
Reaction time trials completed0.61.11.91.41.31.20.7-0.71.31.40.3-0.2
Reaction time trials AUC0.61.12.11.41.31.20.6-0.71.31.40.3-0.3
Run reversals in cocaine runway, females2.12.16.8-0.8-0.5-0.01.6-0.2-2.0-0.4-2.62.1
Run reversals in cocaine runway, males0.40.41.10.80.41.10.80.20.70.30.20.9
Latency to leave start box in cocaine runway1.31.54.81.11.60.20.6-2.20.91.1-1.4-0.6
Latency to leave start box in cocaine runway, F0.70.81.90.61.20.51.1-1.40.30.9-1.10.5
Latency to leave start box in cocaine runway, M1.31.23.30.91.2-0.4-0.4-1.81.00.6-1.1-1.4
Std. dev. time between licks in bursts0.30.51.50.10.7-0.00.7-1.0-0.6-0.1-1.2-0.3
Total sessions with >9 infusions0.50.62.6-0.7-0.5-0.40.00.4-1.2-0.5-1.60.7
Short access day 1 total inactive lever presses0.20.20.4-0.5-0.6-0.5-0.50.3-0.5-0.3-0.1-0.2
Short access day 10 total inactive lever presses0.20.61.5-0.7-0.90.10.31.2-1.00.1-0.61.1
Short access day 1 total infusions0.20.20.80.10.20.20.5-0.3-0.4-0.6-0.90.4
Short access day 10 total infusions3.03.97.9-2.5-1.9-2.8-2.20.9-2.4-1.9-0.7-1.1
Short access total infusions0.50.71.3-0.9-0.7-1.2-1.10.2-0.9-0.9-0.6-0.4
Short access day 1 locomotion1.92.45.8-1.6-0.8-1.6-0.40.3-2.4-2.1-2.30.0
Short access day 10 total locomotion3.46.410.8-3.3-2.6-3.0-2.62.7-3.0-2.7-0.1-0.6
Short access total locomotion3.54.29.8-2.6-2.0-2.1-1.11.7-3.1-2.2-2.00.4
One hour access (0.3 mA shock)1.71.94.2-1.7-2.1-1.0-1.51.7-1.2-1.31.00.1
Compulsive drug intake0.60.73.80.1-0.30.3-0.60.90.7-0.22.0-0.6
One hour access (shock baseline)0.60.92.0-1.3-1.4-1.0-0.70.6-1.3-0.6-0.8-0.1
Social response proportion0.50.62.7-0.6-0.6-0.8-0.70.0-0.3-1.60.6-0.5
Social responses2.22.86.5-2.0-1.6-2.5-2.00.4-1.6-2.0-0.1-1.1
Social time0.20.30.8-0.3-0.70.40.10.9-0.2-0.40.60.8
Soleus weight0.51.54.6-1.3-1.50.00.32.2-1.8-0.7-0.10.8
Bone: stiffness0.81.21.9-1.1-1.2-1.2-1.41.0-0.7-1.30.8-1.2
Tibialis anterior weight0.72.47.6-2.0-1.5-1.4-0.11.1-2.8-1.2-1.90.3
Time to tail flick, vehicle, before self-admin1.41.47.4-0.3-0.90.7-0.11.5-0.11.22.70.5
Time to tail flick, vehicle, after self-admin0.40.53.40.3-0.00.3-0.00.40.5-0.01.8-0.7
Time to tail flick, test, before self-admin0.80.82.4-0.7-0.8-0.6-1.30.80.00.11.5-1.2
Time to tail flick, test, after self-admin1.21.22.3-1.1-1.3-1.1-1.50.8-0.4-0.91.3-1.1
Delta time to tail flick, vehicle, before/after SA1.01.04.60.30.5-0.8-0.9-0.90.8-0.90.3-2.1
Delta time to tail flick, test, before/after SA0.30.30.6-0.1-0.70.50.10.80.1-0.60.80.7
Tibia length0.72.03.9-1.6-2.0-0.5-0.22.0-1.8-1.60.70.9
Ambulatory time before self-admin1.21.93.61.71.91.31.2-1.61.61.20.5-0.3
Ambulatory time after self-admin0.70.82.30.81.5-0.3-0.3-1.21.10.30.7-0.9
Bone: tissue strength1.31.32.41.51.61.31.2-1.41.40.80.00.1
Total heroin consumption0.10.20.80.20.1-0.1-0.4-0.20.40.90.10.3
Bone: trabecular number0.91.54.31.11.10.1-0.7-1.11.61.11.1-2.1
Bone: trabecular spacing0.60.83.2-0.7-0.6-0.30.20.6-1.0-0.8-0.91.8
Bone: trabecular thickness0.40.51.5-0.4-0.6-0.4-0.70.8-0.3-0.21.0-1.2
Bone: trabecular tissue density0.40.51.90.50.60.81.4-0.3-0.3-0.2-1.00.7
Water consumed over 24 hours0.70.92.8-0.10.8-1.1-0.2-1.7-0.4-0.1-1.7-0.6
Number of responses in last shaping day1.01.13.2-0.6-0.80.40.91.0-1.20.7-1.51.8