Hub : Genes

Prkca

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Prkca 0.32 0.11 1.1e-13 0.28 0.31 0.3 0.27 5.1e-12 9.5e-14 6.6e-13 6.4e-12
2 PL gene expression Prkca 0.03 0.02 3.1e-03 0.03 0.02 0.02 0.02 5.9e-04 2.3e-03 1.8e-03 1.5e-03
3 pVTA gene expression Prkca 0.07 0.04 1.1e-04 0.03 0.05 0.04 0.03 1.5e-03 5.9e-05 1.7e-04 2.8e-03
4 pVTA mRNA stability Prkca 0.06 0.04 5.9e-04 0.04 0.03 0.04 0.02 4.2e-04 1.9e-03 4.6e-04 1.7e-02
5 Adipose gene expression Prkca 0.31 0.14 1.0e-13 0.08 0.09 0.09 0.09 4.8e-09 3.0e-10 1.6e-10 6.5e-10
6 Brain gene expression Prkca 0.15 0.07 9.1e-13 0.07 0.1 0.13 0.05 2.9e-07 1.6e-09 6.3e-12 1.4e-05
7 OFC gene expression Prkca 0.23 0.11 5.8e-04 0.05 0.09 0.14 0.06 2.9e-02 3.9e-03 3.7e-04 1.5e-02
8 Liver gene expression Prkca 0.8 0.12 0.0e+00 0.18 0.28 0.29 0.28 1.3e-19 1.1e-31 4.5e-32 9.9e-32
9 NAcc gene expression Prkca 0.02 0.02 7.7e-03 0.01 0.02 0.02 0.01 2.9e-03 1.4e-03 4.2e-04 5.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.30.51.80.4-0.20.00.60.1-0.8-0.6-1.11.3
Area under the delay curve0.10.20.60.10.10.6-0.8-0.60.4-0.4-0.2-0.5
BMI with tail2.79.325.2-3.82.9-3.00.4-1.75.03.03.6-1.2
BMI without tail2.111.227.2-4.22.8-4.01.2-1.45.23.63.9-0.0
Body weight5.624.554.8-6.75.8-5.02.4-5.17.45.31.5-0.7
Weight adjusted by age0.51.67.4-0.00.31.3-1.7-0.80.8-0.40.7-2.7
Bone surface1.53.07.8-0.91.2-1.52.8-1.3-0.5-0.1-2.62.4
Bone volume1.12.14.6-1.01.5-1.22.1-1.60.20.1-2.21.7
Breakpoint value in progressive ratio session1.22.26.01.2-1.50.8-1.31.4-0.5-1.92.4-1.5
Number of licking bursts0.20.51.3-0.71.1-0.10.2-1.20.50.6-0.4-0.6
Context. condit. distance diff. score0.20.31.0-0.40.50.1-0.5-0.40.60.50.3-1.0
Locomotion velocity, session 10.10.10.2-0.10.0-0.40.50.1-0.1-0.3-0.40.1
Locomotion distance, session 10.00.00.30.0-0.2-0.10.00.3-0.1-0.50.0-0.1
Locomotion velocity, session 20.91.12.40.7-1.1-0.61.11.3-1.5-0.7-0.01.3
Locomotion distance, session 20.60.81.90.8-1.3-0.20.31.4-1.0-0.90.50.8
Locomotion velocity, session 31.01.12.31.0-1.31.0-1.51.3-0.4-0.41.1-0.9
Locomotion distance, session 30.20.20.50.2-0.10.7-0.5-0.3-0.20.3-0.5-0.7
Stereotopy head waving bouts, day 34.55.38.92.9-2.92.1-1.93.0-2.4-2.61.0-0.1
Stereotopy head waving duration, day 32.73.45.42.3-2.22.0-1.82.0-1.8-2.30.7-0.5
Locomotion velocity, session 70.30.30.50.5-0.60.5-0.70.5-0.2-0.60.7-0.4
Locomotion distance, session 70.30.40.9-0.60.8-0.20.2-0.90.61.0-0.3-0.1
Stereotopy head waving bouts, day 72.42.85.32.1-2.31.6-1.62.0-1.7-1.31.1-0.8
Stereotopy head waving duration, day 73.84.78.12.8-2.82.2-1.92.5-2.5-2.10.8-0.7
Locomotion velocity, session 80.10.10.30.10.10.00.4-0.2-0.4-0.3-0.6-0.3
Locomotion distance, session 80.10.10.3-0.0-0.3-0.50.40.6-0.3-0.10.10.3
Degree of sensitization distance0.20.20.4-0.50.5-0.70.6-0.40.30.3-0.10.6
Degree of sensitization stereotypy1.11.32.41.1-1.50.8-1.11.4-0.8-0.41.4-1.1
Conditioned locomotion0.20.20.60.6-0.80.20.10.3-0.6-0.60.50.3
Cocaine response after cond. corrected0.40.51.4-0.20.60.6-0.4-1.10.20.9-0.8-1.2
Cocaine response after cond. not corrected0.60.82.7-0.10.60.8-0.4-1.2-0.20.9-1.0-1.6
Cocaine response before conditioning0.20.20.60.4-0.30.6-0.10.0-0.8-0.6-0.5-0.5
Saline control response1.72.45.1-1.70.7-2.10.80.22.11.72.3-0.0
Bone: connectivity density1.52.46.21.4-1.5-0.11.01.5-2.1-1.6-0.92.5
Bone: cortical apparent density2.94.58.12.2-2.62.0-2.82.6-0.9-1.22.6-1.0
Bone: cortical area0.60.92.1-1.10.9-1.41.2-0.41.10.80.70.7
Bone: cortical porosity1.92.06.4-1.41.4-1.72.5-1.40.10.4-1.31.1
Bone: cortical porosity2.22.54.7-2.01.9-1.82.2-1.91.10.8-0.90.4
Bone: cortical thickness3.15.218.91.3-2.11.1-2.92.90.5-0.34.3-1.8
Bone: cortical thickness2.32.810.21.2-1.80.2-1.12.8-0.3-0.63.2-0.3
Bone: cortical tissue density2.84.47.92.2-2.61.9-2.82.6-0.9-1.22.6-1.0
Condit. Reinf. active minus inactive responses2.83.25.8-2.12.4-1.72.0-2.31.31.2-1.60.7
Condit. Reinf. active-inactive response ratio0.91.02.7-0.91.3-0.51.1-1.60.30.2-1.40.3
Condit. Reinf. active responses2.53.24.9-2.12.2-2.02.2-1.81.21.5-1.51.4
Condit. Reinf. inactive responses0.70.92.0-0.90.6-1.31.10.10.61.0-0.61.4
Incentive salience index mean1.31.72.9-1.61.6-1.51.7-1.41.01.0-0.70.9
Condit. Reinf. lever presses0.10.20.6-0.40.1-0.60.30.10.40.50.80.4
Condit. Reinf. active minus inactive responses2.64.08.9-1.81.9-2.23.0-1.90.41.7-2.11.9
Condit. Reinf. active-inactive response ratio1.72.85.0-1.61.8-1.42.2-2.10.41.5-1.91.1
Condit. Reinf. active responses3.55.011.8-2.22.2-2.73.4-1.90.61.8-2.02.3
Condit. Reinf. inactive responses0.81.23.4-0.70.2-1.81.90.50.00.2-0.11.8
Condit. Reinf. lever presses2.73.99.1-2.22.0-2.83.0-1.11.11.7-0.61.9
Condit. Reinf. lever reinforcers received3.75.111.7-2.22.2-2.83.4-1.90.71.8-2.02.3
Conditioned reinforcement - actives0.20.61.8-0.60.8-0.71.3-0.60.1-0.0-0.51.3
Conditioned reinforcement - inactives0.61.52.9-1.61.7-0.90.9-1.61.60.9-0.4-0.2
Conditioned locomotion2.13.14.8-2.12.2-1.91.9-1.91.91.9-0.30.6
Patch foraging indifference point 0 sec2.77.614.5-3.32.8-3.83.1-1.72.93.2-0.52.0
Patch foraging indifference point AUC0.20.51.1-1.00.9-0.90.6-0.70.80.70.00.1
Delay disc. indifference point, 0s delay0.50.51.30.5-0.31.2-1.1-0.2-0.2-1.1-0.0-0.9
Delay disc. indifference point, 16s delay0.10.10.6-0.40.2-0.1-0.3-0.30.80.00.0-0.1
Delay disc. indifference point, 2s delay0.30.31.40.4-0.30.3-0.0-0.3-0.3-0.3-1.20.7
Delay disc. indifference point, 24s delay0.71.13.1-1.31.2-1.10.4-1.01.81.10.20.3
Delay disc. indifference point, 4s delay0.60.71.90.8-0.51.2-1.0-0.0-0.5-1.4-0.4-0.6
Delay disc. indifference point, 8s delay0.40.72.60.6-0.51.1-1.6-0.00.3-0.60.6-1.1
Indifference point function ln k0.41.22.41.5-1.40.9-0.61.5-1.4-0.80.90.1
Indifference point function log k0.41.22.41.5-1.40.9-0.61.5-1.4-0.80.90.1
Patch foraging total patch changes 0 sec2.47.214.2-3.12.6-3.83.1-1.52.73.2-0.62.2
Patch foraging total patch changes 12 sec3.54.69.3-2.62.0-3.02.7-1.61.82.0-1.11.8
Patch foraging total patch changes 18 sec1.12.55.2-2.21.7-2.31.4-1.01.91.90.10.6
Patch foraging total patch changes 24 sec1.03.35.8-2.42.1-2.41.8-1.72.01.9-0.60.7
Patch foraging total patch changes 6 sec5.28.914.5-3.73.3-3.62.9-2.63.33.8-0.61.0
Patch foraging time to switch 0 sec0.10.30.9-0.10.30.4-0.7-0.50.50.4-0.4-0.9
Patch foraging water rate 0 sec0.41.53.4-1.10.7-1.81.9-0.20.61.30.21.7
Patch foraging water rate 12 sec0.10.20.8-0.40.4-0.2-0.0-0.20.70.30.9-0.7
Patch foraging water rate 18 sec0.20.41.30.5-0.7-0.30.11.2-0.30.20.80.5
Patch foraging water rate 24 sec0.50.71.21.1-1.00.9-0.61.0-1.1-0.8-0.00.2
Patch foraging water rate 6 sec0.81.12.81.1-1.50.3-0.51.7-0.8-0.41.60.6
Seeking ratio, delayed vs. immediate footshock0.30.41.2-0.70.80.1-0.7-0.81.10.30.2-0.4
Distance traveled before self-admin0.71.52.71.6-1.61.3-1.11.1-1.5-1.3-0.90.0
Distance traveled after self-admin0.30.41.90.5-0.9-0.10.30.2-0.8-0.2-1.40.2
Extensor digitorum longus weight0.83.37.1-0.90.81.0-2.4-1.12.60.22.5-2.7
Bone: elastic displacement1.11.43.31.3-1.51.0-1.31.8-0.9-1.00.9-0.7
Bone: elastic work0.30.41.7-0.2-0.2-0.6-0.00.80.70.31.30.0
Bone: endosteal estimation9.322.746.6-4.85.6-4.76.8-5.82.12.7-4.93.3
Bone: endosteal perimeter8.320.435.5-4.65.5-4.16.0-5.92.22.6-5.12.8
Epididymis fat weight1.68.323.0-3.93.4-2.40.4-2.84.82.71.3-1.4
Delta time in closed arm before/after self-admin0.40.30.80.7-0.40.9-0.4-0.1-0.7-0.4-0.80.0
Delta time in open arm before/after self-admin0.50.61.01.0-0.80.8-0.80.9-0.9-1.0-0.10.3
Diff in mean of infusions in LGA sessions0.91.77.40.5-0.70.6-1.41.00.4-1.02.7-1.5
Delay discount exponential model param0.20.20.70.1-0.4-0.40.50.9-0.60.20.40.5
Extinction: sum of active levers before priming0.30.51.50.1-0.20.5-0.8-0.20.5-0.81.2-1.2
Active lever presses in extinction session 60.40.41.2-0.2-0.5-1.10.80.50.2-0.50.10.8
Bone: final force0.50.82.0-0.70.6-1.21.4-0.40.40.8-0.41.4
Bone: final moment0.60.92.6-0.60.6-1.21.5-0.30.30.8-0.51.6
Food consumed during 24 hour testing period1.01.95.5-1.0-0.0-2.31.21.11.40.72.01.4
Glucose1.11.75.50.5-0.01.7-1.9-0.70.3-1.40.8-2.3
Heart weight0.81.33.2-1.11.20.1-0.6-1.81.80.50.2-1.5
Delay discount hyperbolic model param0.20.20.60.0-0.3-0.60.60.8-0.50.30.40.5
Intermittent access intake day 1-15 change0.63.49.3-2.22.7-0.80.9-3.11.91.2-0.4-1.6
Intermittent access intake escalation0.63.38.1-2.32.6-1.01.0-2.81.91.4-0.2-1.3
Intermittent access intake escalation 21.83.16.9-2.22.6-1.21.4-2.51.51.7-1.1-0.4
Intermitt. access day 1 inactive lever presses0.22.84.7-2.21.9-1.51.1-2.02.11.50.6-1.4
Intermitt. access day 15 inactive lever presses0.41.94.1-1.91.8-1.20.7-1.62.00.90.7-0.7
Intermitt. access escalation Index0.20.51.01.0-0.80.7-0.40.8-0.9-0.90.1-0.3
Intermittent access day 1 total infusions0.10.30.8-0.80.6-0.90.9-0.10.60.20.10.3
Intermittent access day 15 total infusions1.63.87.6-2.72.8-1.91.7-2.42.31.40.0-0.3
Intermittent access terminal intake (last 3 days)2.95.09.4-2.93.1-2.32.5-2.52.11.9-1.20.8
Intermittent access total infusions2.42.95.1-2.22.3-1.92.0-1.61.61.5-0.60.9
Intermittent access day 1 locomotion2.44.58.0-2.82.4-2.41.9-1.92.72.30.70.2
Intermittent access day 15 total locomotion1.66.310.4-3.22.9-3.12.8-2.22.82.60.01.1
Intermittent access total locomotion8.29.816.7-4.13.7-3.83.3-2.73.73.20.21.2
Intermittent access standard deviation1.15.815.9-2.83.5-0.80.9-4.02.72.0-1.1-1.3
Left kidney weight0.11.02.7-1.10.9-0.70.0-0.71.60.51.5-0.9
Right kidney weight0.21.54.6-1.31.1-0.9-0.1-0.82.20.61.7-1.0
Cocaine induced anxiety0.20.41.20.6-0.10.7-0.10.0-1.1-1.1-0.8-0.0
Post-drug Anxiety1.11.32.31.4-0.91.5-1.20.7-1.4-1.5-0.1-0.4
Baseline Anxiety0.71.22.51.3-1.50.8-1.21.6-0.7-0.71.3-0.2
Tail length1.26.512.5-3.22.5-3.53.0-1.92.72.6-0.21.8
Length with tail2.611.621.6-4.34.2-3.02.7-4.63.93.3-2.10.3
Length without tail1.05.112.9-2.62.9-0.90.5-3.62.92.2-1.2-1.2
Times rat made contact with spout0.70.81.8-1.21.1-1.31.2-0.40.70.6-0.20.0
Lifetime Intake1.82.23.5-1.91.8-1.81.8-1.11.61.4-0.10.8
Liver weight, left1.42.34.9-1.81.8-1.92.2-1.50.81.2-1.10.9
Liver weight, right0.40.74.4-0.2-0.1-0.3-0.40.40.6-0.12.1-0.8
Locomotor activity1.62.46.8-1.91.1-2.61.8-0.51.61.41.11.0
Locomotor testing distance0.61.54.7-1.50.7-2.21.5-0.11.20.91.10.9
Locomotor testing rearing0.41.64.2-1.50.6-2.11.50.31.20.51.90.5
Locomotion in novel chamber0.60.81.90.9-0.91.0-1.00.4-0.6-1.40.2-1.1
Locomotion in novel chamber post-restriction0.20.73.3-0.30.3-0.40.5-0.2-0.00.9-1.81.2
Fecal boli incidents, locomotor time 10.30.92.3-0.21.01.0-0.4-1.50.2-1.3-0.9-1.0
Change in fecal boli incidents, locomotor task0.60.72.50.5-0.8-0.30.50.7-0.70.3-1.01.6
Time >=10cm from walls, locomotor time 10.50.61.80.8-0.61.3-1.00.1-1.0-0.6-0.5-0.6
Bouts of movement, locomotor time 10.60.82.3-0.70.7-0.2-0.5-0.51.30.71.5-1.1
Total resting periods, locomotor time 10.60.71.5-0.60.70.1-0.6-0.71.20.31.2-1.2
Rest time, locomotor task time 10.50.82.40.50.11.4-1.1-0.5-0.2-1.00.5-1.5
Distance moved, locomotor task time 10.20.61.6-0.3-0.5-0.90.20.90.51.10.81.3
Vertical activity count, locomotor time 10.10.41.8-0.3-0.1-0.70.20.40.31.30.21.0
Time >=10cm from walls, locomotor time 20.41.15.90.4-1.00.1-0.60.9-0.3-0.72.4-1.0
Bouts of movement, locomotor time 20.51.66.0-0.80.2-0.3-1.20.41.90.72.5-1.3
Total resting periods, locomotor time 20.31.44.1-0.70.30.0-1.40.01.80.72.0-1.5
Rest time, locomotor task time 22.94.914.32.5-1.43.8-2.90.5-1.8-2.5-0.5-1.7
Distance moved, locomotor task time 21.21.67.0-0.6-0.6-1.80.81.20.70.72.60.7
Vertical activity count, locomotor time 21.33.08.7-1.70.7-2.92.00.21.31.92.01.0
Light reinforcement 10.41.88.20.3-1.3-0.5-0.91.90.70.72.90.6
Light reinforcement 20.40.82.80.5-0.61.0-1.70.20.50.71.3-0.6
Bone: marrow area8.921.845.2-4.75.5-4.66.7-5.72.02.7-4.83.2
Bone: maximum diameter2.34.79.6-1.82.3-1.83.1-2.80.60.9-2.82.0
Bone: maximum force1.12.23.4-1.61.7-1.61.8-1.41.21.5-0.81.3
Bone: maximum moment1.22.23.8-1.51.7-1.72.0-1.31.11.5-0.91.5
Mean time between licks in bursts0.42.56.4-2.02.2-0.70.1-2.12.51.4-0.4-0.8
Mean num. licks in bursts0.10.20.90.1-0.5-0.40.20.90.0-0.20.50.4
Cd content in liver0.80.92.40.8-0.31.6-1.2-0.4-0.7-0.5-1.5-0.6
Co content in liver0.50.62.80.3-0.01.3-1.7-0.30.20.1-0.2-0.9
Cu content in liver0.10.10.3-0.10.2-0.10.3-0.5-0.10.4-0.40.5
Fe content in liver0.20.20.7-0.00.1-0.30.7-0.2-0.40.7-0.90.4
K content in liver0.60.61.61.1-0.70.8-0.30.7-1.3-0.2-0.80.6
Mg content in liver1.92.04.12.0-1.91.1-0.61.8-2.0-0.9-0.31.0
Mn content in liver2.62.96.22.1-2.30.60.32.0-2.5-1.7-0.71.6
Na content in liver0.70.81.51.1-0.81.1-0.60.6-1.2-0.9-0.60.6
Rb content in liver1.11.32.81.5-1.21.3-0.60.8-1.7-1.0-0.90.3
Se content in liver1.51.83.31.5-1.31.8-1.81.0-1.1-1.10.2-1.4
Sr content in liver0.60.51.2-0.90.7-0.50.0-0.61.10.10.9-0.8
Zn content in liver0.40.51.70.7-0.21.3-1.00.1-0.8-0.1-0.6-0.5
Bone: minimum diameter7.815.025.2-4.34.8-4.15.0-4.62.72.9-3.12.3
Time in familiar zone, hab. session 11.31.53.4-1.31.7-0.91.2-1.80.90.8-1.10.2
Time in novel zone, hab. session 10.91.02.31.0-1.30.4-0.71.5-0.7-0.41.5-0.1
Total zone transitions, hab. session 10.40.61.4-0.80.3-1.20.5-0.01.10.21.10.4
Total locomotion distance, hab. session 10.81.13.1-0.6-0.3-1.81.11.00.70.31.11.5
Locomotion velocity, hab. session 10.60.92.5-0.5-0.4-1.61.00.90.60.10.91.5
Time in familiar zone, hab. session 21.01.11.7-1.21.3-1.01.3-1.30.71.3-0.70.1
Time in novel zone, hab. session 21.71.83.61.7-1.80.9-0.91.9-1.4-1.50.40.7
Total zone transitions, hab. session 20.40.52.8-0.4-0.4-0.80.00.70.70.21.7-0.3
Total locomotion distance, hab. session 20.81.02.8-0.3-0.9-1.50.41.40.50.11.70.9
Locomotion velocity, hab. session 20.81.02.90.1-1.2-1.10.21.70.2-0.11.70.9
Novel to familiar place preference ratio1.92.54.6-1.82.2-1.31.4-2.11.51.8-1.20.4
Novelty place preference1.41.83.2-1.51.8-1.01.2-1.81.21.5-1.00.3
Time in novel zone, NPP test1.21.52.6-1.41.6-1.01.1-1.51.11.5-1.00.3
Total zone transitions, NPP test0.60.92.70.4-1.3-0.5-0.11.5-0.1-0.41.60.5
Total locomotion distance, NPP test1.41.95.10.4-1.6-1.51.02.3-0.5-0.21.22.1
Locomotion velocity, NPP test0.81.23.50.2-1.4-1.20.31.90.00.01.41.4
Intraocular pressure0.10.20.5-0.60.4-0.50.2-0.40.70.10.3-0.1
Delta distance traveled before/after self-admin0.40.41.6-0.60.0-1.31.10.20.20.50.20.5
Delta ambulatory time before/after self-admin0.50.82.6-0.80.4-1.61.6-0.30.20.6-0.50.7
Parametrial fat weight0.40.92.20.9-0.70.50.20.3-1.1-0.9-1.51.4
Pavlov. Cond. lever latency1.31.73.21.6-1.11.5-0.70.9-1.7-1.8-1.20.2
Pavlov. Cond. magazine entry latency1.51.93.2-1.61.4-1.81.6-1.11.21.7-0.40.9
Pavlov. Cond. change in total contacts1.92.03.7-1.81.5-1.91.5-1.11.51.80.50.4
Pavlov. Cond. index score1.62.03.8-1.81.5-1.81.3-1.21.51.90.20.5
Pavlov. Cond. latency score1.62.14.3-1.81.5-1.61.0-1.31.72.10.40.0
Pavlov. Cond. lever contacts1.31.63.3-1.51.1-1.40.6-1.01.71.81.0-0.3
Pavlov. Cond. magazine entry number1.11.42.21.4-1.31.4-1.31.1-1.1-1.50.6-0.6
Pavlov. Cond. intertrial magazine entries2.12.55.0-2.02.2-1.31.3-1.81.81.5-1.20.6
Pavlov. Cond. lever-magazine prob. diff.1.31.62.9-1.61.3-1.71.3-1.01.41.70.20.6
Pavlov. Cond. response bias1.11.42.8-1.31.0-1.71.6-0.90.91.3-0.31.1
Pavlov. Cond. lever latency0.50.72.10.6-0.80.9-1.50.30.2-0.21.0-0.9
Pavlov. Cond. magazine entry latency0.60.92.30.40.21.5-1.4-0.5-0.2-0.8-0.4-1.5
Pavlov. Cond. change in total contacts0.20.41.4-0.30.6-0.51.0-0.6-0.40.1-1.20.5
Pavlov. Cond. index score0.30.51.3-0.61.0-0.30.7-1.0-0.0-0.1-1.10.0
Pavlov. Cond. latency score0.30.41.6-0.40.90.00.5-1.0-0.2-0.3-1.3-0.1
Pavlov. Cond. lever contacts0.30.51.7-0.50.6-0.91.30.0-0.20.1-0.60.9
Pavlov. Cond. magazine entry number0.81.13.1-0.60.1-1.71.70.30.30.80.31.8
Pavlov. Cond. intertrial magazine entries1.84.010.5-1.40.6-3.23.10.20.81.80.03.1
Pavlov. Cond. lever-magazine prob. diff.0.30.41.5-0.50.9-0.10.6-0.9-0.1-0.2-1.2-0.1
Pavlov. Cond. response bias0.20.20.7-0.40.6-0.50.8-0.2-0.20.1-0.70.4
Time in closed arm before self-admin0.61.03.5-0.6-0.3-1.91.10.80.60.51.40.6
Time in closed arm after self-admin0.10.10.5-0.4-0.1-0.70.3-0.10.40.10.3-0.1
Time in open arm before self-admin1.51.84.1-1.11.80.9-1.2-1.71.50.4-0.3-2.0
Time in open arm after self-admin0.60.61.4-0.10.81.2-1.1-0.90.40.1-0.8-0.9
Bone: periosteal estimation5.613.328.1-3.94.4-4.05.3-4.12.02.2-2.92.7
Bone: periosteal perimeter3.46.715.4-2.93.5-1.92.8-3.91.81.7-2.50.7
Bone: post-yield work2.03.57.5-2.32.7-1.51.7-2.51.81.7-1.20.3
Progressive ratio test 1 active lever presses2.13.78.1-2.41.9-2.92.3-0.82.31.50.61.4
Progressive ratio test 1 breakpoint2.23.88.8-2.41.8-3.02.4-0.72.21.50.71.6
Progressive ratio test 1 inactive lever presses1.94.98.9-2.92.4-3.02.5-1.72.72.10.50.6
Progressive ratio test 2 active lever presses1.01.42.3-1.41.2-1.51.5-0.91.21.1-0.50.8
Progressive ratio test 2 breakpoint1.21.52.6-1.41.2-1.61.6-0.91.21.2-0.61.0
Progressive ratio test 2 inactive lever presses0.51.63.3-1.71.5-1.51.0-1.01.81.00.30.6
Incentive Sensitization - Responses0.10.10.70.20.00.5-0.1-0.3-0.4-0.2-0.80.0
Incentive Sensitization - Breakpoint0.10.20.90.30.10.5-0.1-0.3-0.5-0.2-0.90.0
Sum of active levers in priming session hrs 5-60.80.72.40.6-0.90.4-0.60.4-0.1-1.61.1-1.1
Progressive ratio0.31.02.20.20.01.4-1.3-1.20.1-0.6-1.5-1.2
Food seeking constrained by brief footshock1.41.85.2-0.90.4-1.72.3-0.5-0.10.4-1.62.0
Seeking ratio, punishment vs. effort0.81.85.3-0.70.3-2.22.30.80.00.70.32.1
Retroperitoneal fat weight1.46.116.6-3.32.5-2.40.4-1.94.12.61.8-1.0
Reaction time number correct0.31.22.01.4-1.31.3-0.80.7-1.4-1.4-0.30.1
Reaction time mean minus median0.00.10.3-0.00.20.4-0.3-0.30.2-0.60.1-0.2
Reaction time mean minus median AUC0.10.40.90.7-0.40.60.00.2-0.7-0.9-0.60.6
Reaction time num false alarms1.42.44.1-2.02.0-1.91.7-1.51.61.4-0.20.4
Reaction time num false alarms AUC1.22.84.6-2.12.1-2.12.1-1.51.51.6-0.40.6
Reaction time trials correct on left0.31.22.01.4-1.31.3-0.80.7-1.4-1.4-0.30.1
Reaction time trials on left0.31.11.91.4-1.31.2-0.70.7-1.3-1.4-0.30.2
Reaction time mean0.30.61.70.8-0.40.8-0.20.4-1.0-1.3-0.80.2
Reaction time mean AUC0.20.61.90.9-0.50.8-0.20.7-1.0-1.4-0.40.1
Median of all reaction times0.50.82.01.0-0.60.8-0.20.7-1.3-1.4-0.80.4
Reaction time omissions0.30.50.9-0.70.6-1.00.9-0.30.80.7-0.30.9
Reaction time false alarm rate2.63.66.2-2.42.5-2.32.1-1.71.91.9-0.20.2
Reaction time premature initiation rate1.21.83.2-1.71.7-1.10.6-1.21.81.50.8-1.1
Reaction time premature initiations0.10.30.5-0.60.7-0.30.2-0.60.70.50.6-0.7
Std. dev. reaction times0.10.20.90.30.00.40.2-0.2-0.5-0.8-0.90.1
Reaction time trials completed0.31.11.91.4-1.31.2-0.70.7-1.3-1.4-0.30.2
Reaction time trials AUC0.31.12.11.4-1.31.2-0.60.7-1.3-1.4-0.30.3
Run reversals in cocaine runway, females1.92.16.8-0.80.5-0.0-1.60.22.00.42.6-2.1
Run reversals in cocaine runway, males0.40.41.10.8-0.41.1-0.8-0.2-0.7-0.3-0.2-0.9
Latency to leave start box in cocaine runway1.11.54.81.1-1.60.2-0.62.2-0.9-1.11.40.6
Latency to leave start box in cocaine runway, F0.70.81.90.6-1.20.5-1.11.4-0.3-0.91.1-0.5
Latency to leave start box in cocaine runway, M1.21.23.30.9-1.2-0.40.41.8-1.0-0.61.11.4
Std. dev. time between licks in bursts0.20.51.50.1-0.7-0.0-0.71.00.60.11.20.3
Total sessions with >9 infusions0.50.62.6-0.70.5-0.4-0.0-0.41.20.51.6-0.7
Short access day 1 total inactive lever presses0.10.20.4-0.50.6-0.50.5-0.30.50.30.10.2
Short access day 10 total inactive lever presses0.10.61.5-0.70.90.1-0.3-1.21.0-0.10.6-1.1
Short access day 1 total infusions0.10.20.80.1-0.20.2-0.50.30.40.60.9-0.4
Short access day 10 total infusions2.33.97.9-2.51.9-2.82.2-1.02.41.90.71.1
Short access total infusions0.50.71.3-0.90.7-1.21.1-0.30.90.90.60.4
Short access day 1 locomotion1.42.45.8-1.60.8-1.60.4-0.32.42.12.3-0.0
Short access day 10 total locomotion1.66.410.8-3.32.6-3.02.6-2.73.02.70.10.6
Short access total locomotion2.84.29.8-2.62.0-2.11.1-1.73.12.22.0-0.4
One hour access (0.3 mA shock)1.61.94.2-1.72.1-1.01.5-1.71.21.3-1.0-0.1
Compulsive drug intake0.50.73.80.10.30.30.6-0.9-0.70.2-2.00.6
One hour access (shock baseline)0.30.92.0-1.31.4-1.00.7-0.61.30.60.80.1
Social response proportion0.50.62.7-0.60.6-0.80.7-0.00.31.6-0.60.5
Social responses2.12.86.5-2.01.6-2.52.0-0.41.62.00.11.1
Social time0.20.30.8-0.30.70.4-0.1-0.90.20.4-0.6-0.8
Soleus weight0.51.54.6-1.31.50.0-0.3-2.11.80.70.1-0.8
Bone: stiffness0.71.21.9-1.11.2-1.21.4-1.00.71.3-0.81.2
Tibialis anterior weight0.72.47.6-2.01.5-1.40.1-1.12.81.21.9-0.3
Time to tail flick, vehicle, before self-admin1.11.47.4-0.30.90.70.1-1.50.1-1.2-2.7-0.5
Time to tail flick, vehicle, after self-admin0.20.53.40.30.00.30.0-0.4-0.50.0-1.80.7
Time to tail flick, test, before self-admin0.70.82.4-0.70.8-0.61.3-0.8-0.0-0.1-1.51.2
Time to tail flick, test, after self-admin1.11.22.3-1.11.3-1.11.5-0.90.40.9-1.31.1
Delta time to tail flick, vehicle, before/after SA0.91.04.60.3-0.5-0.80.90.9-0.80.9-0.32.1
Delta time to tail flick, test, before/after SA0.20.30.6-0.10.70.5-0.1-0.8-0.10.6-0.8-0.7
Tibia length0.72.03.9-1.62.0-0.50.2-2.01.81.6-0.7-0.9
Ambulatory time before self-admin0.61.93.61.7-1.91.3-1.21.6-1.6-1.2-0.50.3
Ambulatory time after self-admin0.50.82.30.8-1.5-0.30.31.2-1.1-0.3-0.70.9
Bone: tissue strength1.31.42.41.5-1.61.3-1.21.4-1.4-0.8-0.0-0.1
Total heroin consumption0.10.20.80.2-0.1-0.10.40.2-0.4-0.9-0.1-0.3
Bone: trabecular number0.81.54.31.1-1.10.10.71.1-1.6-1.1-1.12.1
Bone: trabecular spacing0.50.83.2-0.70.6-0.3-0.2-0.61.00.80.9-1.8
Bone: trabecular thickness0.40.51.5-0.40.6-0.40.7-0.80.30.3-1.01.2
Bone: trabecular tissue density0.30.51.90.5-0.60.8-1.40.40.30.21.0-0.7
Water consumed over 24 hours0.50.92.8-0.1-0.8-1.10.21.70.40.11.70.6
Number of responses in last shaping day0.91.13.2-0.60.80.4-0.9-1.01.2-0.71.5-1.8