Hub : Genes

Prkag1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Prkag1 0.46 0.17 4.0e-12 0.33 0.35 0.28 0.36 1.2e-08 3.8e-09 2.3e-07 1.7e-09
2 NAcc intron excision ratio chr7_131862597_131862698 0.01 0.01 3.0e-03 0.01 0.01 0.01 0.01 2.2e-03 2.2e-03 1.6e-02 7.0e-03
3 Brain gene expression Prkag1 0.4 0.14 0.0e+00 0.53 0.54 0.54 0.54 6.1e-58 1.3e-59 1.7e-59 9.5e-60
4 LHb gene expression Prkag1 0.46 0.18 8.2e-09 0.27 0.25 0.24 0.26 4.3e-07 1.1e-06 2.4e-06 7.8e-07
5 IC gene expression Prkag1 0.14 0.1 1.2e-05 0.11 0.12 0.11 0.11 1.7e-05 1.5e-05 3.4e-05 2.1e-05
6 NAcc intron excision ratio chr7_131854309_131859157 0.04 0.03 1.4e-07 0.05 0.05 0.04 0.05 7.9e-08 1.2e-07 1.7e-07 7.5e-08
7 PL alternative TSS XM_006257331.5 0.02 0.02 3.1e-03 0.02 0.02 0.02 0.02 2.1e-03 1.9e-03 5.8e-03 3.1e-03
8 NAcc gene expression Prkag1 0.25 0.09 0.0e+00 0.36 0.37 0.37 0.37 9.5e-58 2.2e-58 3.0e-59 3.1e-59
9 OFC gene expression Prkag1 0.6 0.19 2.0e-08 0.23 0.2 0.2 0.22 4.1e-06 1.3e-05 1.9e-05 4.6e-06
10 PL alternative TSS NM_013010.2 0.02 0.02 4.3e-03 0.02 0.02 0.02 0.02 3.7e-03 2.4e-03 6.4e-03 3.9e-03
11 PL gene expression Prkag1 0.36 0.15 0.0e+00 0.4 0.4 0.4 0.4 3.7e-47 5.4e-47 5.0e-47 3.2e-47
12 Adipose gene expression Prkag1 0.04 0.03 1.6e-04 0.04 0.03 0.03 0.03 7.7e-05 6.1e-04 2.6e-04 1.1e-04
13 pVTA gene expression Prkag1 0.09 0.06 1.5e-08 0.12 0.1 0.11 0.11 6.6e-10 1.3e-08 3.5e-09 2.2e-09
14 BLA gene expression Prkag1 0.21 0.11 3.6e-13 0.22 0.23 0.22 0.22 4.2e-12 1.7e-12 5.3e-12 4.8e-12
15 RMTg gene expression Prkag1 0.51 0.22 2.0e-11 0.32 0.34 0.33 0.36 2.2e-09 5.7e-10 1.5e-09 2.8e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density9.116.718.4-4.34.2-4.24.2-4.1-4.1-4.14.34.14.1-4.34.04.0-4.0-3.2
Area under the delay curve0.50.81.0-1.00.9-1.01.0-0.9-0.8-0.90.90.80.9-0.80.80.8-0.9-0.7
BMI with tail6.522.825.7-4.94.9-5.14.8-4.9-4.8-4.94.84.84.9-4.84.64.6-4.8-4.2
BMI without tail1.05.26.5-2.32.4-2.62.2-2.3-2.2-2.42.32.12.4-2.32.02.0-2.4-2.3
Body weight6.729.232.7-5.55.6-5.75.4-5.5-5.3-5.65.45.35.6-5.35.15.1-5.5-5.0
Weight adjusted by age1.44.06.2-1.92.0-1.91.9-2.0-1.9-2.11.91.92.1-1.91.91.9-2.2-2.5
Bone surface10.721.124.3-4.94.7-4.84.8-4.6-4.6-4.64.74.64.6-4.74.54.5-4.5-3.7
Bone volume8.016.018.8-4.34.1-4.24.2-4.0-4.0-4.04.23.94.0-4.23.93.9-3.9-3.2
Breakpoint value in progressive ratio session0.91.72.2-1.31.3-1.31.2-1.3-1.3-1.31.11.41.3-1.11.51.5-1.3-1.4
Number of licking bursts0.10.40.70.7-0.60.5-0.80.60.80.4-0.8-0.8-0.40.7-0.8-0.80.3-0.3
Context. condit. distance diff. score0.30.30.6-0.50.6-0.60.5-0.6-0.5-0.60.50.50.6-0.50.60.6-0.7-0.8
Locomotion velocity, session 10.70.81.00.9-1.00.9-0.81.00.91.0-1.0-0.9-1.01.0-0.9-0.90.90.6
Locomotion distance, session 12.73.54.72.1-1.92.0-1.81.91.72.0-1.8-1.6-2.01.8-1.6-1.62.02.2
Locomotion velocity, session 20.20.30.50.5-0.50.5-0.40.50.40.5-0.4-0.5-0.50.4-0.5-0.50.60.7
Locomotion distance, session 22.33.24.71.9-1.81.9-1.61.81.71.9-1.6-1.7-1.91.7-1.6-1.61.92.2
Locomotion velocity, session 34.04.64.92.1-2.22.2-2.12.22.22.2-2.1-2.2-2.22.1-2.1-2.12.22.2
Locomotion distance, session 34.85.55.92.3-2.42.4-2.22.42.32.4-2.2-2.4-2.42.2-2.3-2.32.42.3
Stereotopy head waving bouts, day 31.31.62.1-1.51.2-1.41.4-1.2-1.1-1.21.41.11.2-1.41.01.0-1.3-1.3
Stereotopy head waving duration, day 30.70.81.2-1.10.9-1.01.0-0.9-0.9-0.91.00.90.9-1.00.80.8-0.9-0.8
Locomotion velocity, session 70.20.20.40.3-0.50.4-0.30.40.50.4-0.4-0.6-0.40.4-0.6-0.60.4-0.0
Locomotion distance, session 71.51.92.51.3-1.41.4-1.21.41.51.3-1.3-1.6-1.31.3-1.6-1.61.30.8
Stereotopy head waving bouts, day 71.51.72.9-1.51.3-1.41.3-1.3-1.1-1.41.31.21.4-1.31.11.1-1.4-1.7
Stereotopy head waving duration, day 71.21.52.0-1.41.2-1.31.2-1.2-1.1-1.21.11.11.2-1.11.11.1-1.3-1.4
Locomotion velocity, session 80.00.00.10.10.1-0.0-0.1-0.1-0.0-0.1-0.10.20.10.10.10.1-0.1-0.3
Locomotion distance, session 81.21.72.41.4-1.31.4-1.31.31.21.3-1.2-1.2-1.31.3-1.1-1.11.41.6
Degree of sensitization distance0.50.51.0-0.70.7-0.80.7-0.7-0.6-0.80.70.70.8-0.70.60.6-0.8-1.0
Degree of sensitization stereotypy0.20.20.8-0.50.4-0.60.4-0.4-0.2-0.50.30.30.5-0.30.20.2-0.6-0.9
Conditioned locomotion0.10.10.6-0.20.1-0.20.3-0.2-0.1-0.20.20.00.2-0.20.20.2-0.3-0.8
Cocaine response after cond. corrected0.00.10.70.2-0.10.1-0.10.20.00.2-0.0-0.0-0.20.1-0.1-0.10.30.8
Cocaine response after cond. not corrected0.60.92.10.9-0.90.8-0.90.90.81.0-0.8-0.8-1.00.8-0.9-0.91.11.5
Cocaine response before conditioning3.64.44.92.1-2.22.1-2.12.12.12.1-2.1-2.1-2.12.1-2.0-2.02.11.8
Saline control response0.00.00.1-0.20.1-0.20.2-0.1-0.2-0.10.20.20.1-0.20.20.2-0.00.2
Bone: connectivity density6.510.411.7-3.43.3-3.43.3-3.2-3.3-3.23.43.33.2-3.43.23.2-3.1-2.3
Bone: cortical apparent density0.10.20.30.5-0.50.5-0.60.50.40.5-0.4-0.5-0.50.4-0.4-0.40.50.2
Bone: cortical area10.817.519.5-4.44.3-4.44.4-4.2-4.0-4.34.14.04.3-4.14.04.0-4.3-4.0
Bone: cortical porosity0.70.71.10.7-1.01.0-0.70.90.71.0-0.8-0.7-1.00.7-0.7-0.71.01.0
Bone: cortical porosity0.91.01.30.8-1.11.1-0.81.10.91.1-0.9-0.9-1.20.9-0.9-0.91.21.0
Bone: cortical thickness4.37.28.6-2.82.8-2.92.8-2.7-2.5-2.82.52.42.8-2.52.42.4-2.9-2.8
Bone: cortical thickness0.10.20.3-0.50.5-0.50.6-0.4-0.2-0.50.30.20.5-0.40.10.1-0.5-0.6
Bone: cortical tissue density0.20.30.40.6-0.60.7-0.70.60.50.6-0.5-0.5-0.60.5-0.5-0.50.60.3
Condit. Reinf. active minus inactive responses0.10.10.50.1-0.20.2-0.00.20.20.3-0.2-0.2-0.30.2-0.2-0.20.30.7
Condit. Reinf. active-inactive response ratio0.30.30.5-0.60.5-0.50.7-0.5-0.6-0.40.60.60.4-0.60.60.6-0.40.1
Condit. Reinf. active responses0.50.71.20.7-0.80.8-0.70.80.80.8-0.8-0.9-0.80.8-0.8-0.80.91.1
Condit. Reinf. inactive responses2.73.43.81.8-1.91.8-1.91.91.91.8-1.9-1.9-1.81.9-1.9-1.91.81.6
Incentive salience index mean0.00.00.0-0.20.2-0.10.2-0.1-0.1-0.10.10.10.1-0.10.10.1-0.10.1
Condit. Reinf. lever presses0.10.10.2-0.30.5-0.30.3-0.4-0.3-0.50.30.30.5-0.30.30.3-0.5-0.5
Condit. Reinf. active minus inactive responses0.00.00.00.1-0.20.2-0.10.10.10.2-0.1-0.1-0.20.1-0.2-0.20.10.1
Condit. Reinf. active-inactive response ratio0.20.40.50.6-0.60.6-0.60.60.60.6-0.6-0.5-0.60.6-0.7-0.70.60.6
Condit. Reinf. active responses0.20.30.40.5-0.60.6-0.50.50.50.6-0.5-0.5-0.60.4-0.6-0.60.60.4
Condit. Reinf. inactive responses0.40.70.80.8-0.90.9-0.80.80.80.8-0.8-0.8-0.80.8-0.8-0.80.80.5
Condit. Reinf. lever presses0.00.00.0-0.00.1-0.00.0-0.1-0.1-0.10.10.10.1-0.20.00.0-0.10.0
Condit. Reinf. lever reinforcers received0.50.70.80.8-0.90.9-0.80.80.80.9-0.8-0.8-0.90.8-0.9-0.90.90.7
Conditioned reinforcement - actives0.41.82.81.2-1.31.2-1.31.31.41.3-1.4-1.4-1.21.4-1.7-1.71.20.8
Conditioned reinforcement - inactives2.15.77.22.2-2.42.2-2.22.42.52.4-2.5-2.6-2.42.4-2.7-2.72.32.0
Conditioned locomotion0.10.20.40.5-0.50.5-0.50.50.50.4-0.4-0.4-0.40.4-0.6-0.60.40.1
Patch foraging indifference point 0 sec1.33.84.41.9-1.91.8-1.91.92.01.9-2.0-2.1-1.92.0-2.0-2.01.91.9
Patch foraging indifference point AUC0.51.11.40.9-1.10.8-0.91.11.11.1-1.0-1.2-1.11.0-1.1-1.11.11.0
Delay disc. indifference point, 0s delay1.21.41.7-1.31.1-1.31.3-1.1-1.1-1.11.11.11.1-1.11.11.1-1.1-1.1
Delay disc. indifference point, 16s delay0.60.81.0-0.91.0-1.00.9-0.9-0.8-1.00.80.81.0-0.80.80.8-1.0-1.0
Delay disc. indifference point, 2s delay1.21.41.5-1.11.2-1.11.1-1.2-1.2-1.21.21.21.2-1.21.21.2-1.2-1.0
Delay disc. indifference point, 24s delay0.71.21.3-1.11.1-1.11.1-1.1-1.0-1.11.01.01.1-1.01.11.1-1.1-1.2
Delay disc. indifference point, 4s delay0.30.30.4-0.50.6-0.60.4-0.5-0.6-0.50.60.60.5-0.60.60.6-0.4-0.1
Delay disc. indifference point, 8s delay1.32.22.8-1.61.6-1.71.6-1.5-1.4-1.51.41.41.5-1.41.41.4-1.5-1.2
Indifference point function ln k1.75.35.5-2.32.3-2.22.3-2.3-2.3-2.32.32.32.3-2.32.32.3-2.3-2.2
Indifference point function log k1.75.35.5-2.32.3-2.22.3-2.3-2.3-2.32.32.32.3-2.32.32.3-2.3-2.2
Patch foraging total patch changes 0 sec1.33.74.31.9-1.91.8-1.91.92.01.9-2.0-2.1-1.92.0-2.0-2.01.91.8
Patch foraging total patch changes 12 sec2.33.14.01.7-1.81.6-1.71.81.91.7-1.9-2.0-1.71.9-1.8-1.81.71.4
Patch foraging total patch changes 18 sec2.45.66.72.2-2.42.2-2.22.42.42.4-2.3-2.6-2.42.3-2.3-2.32.42.3
Patch foraging total patch changes 24 sec0.82.83.81.6-1.71.5-1.61.71.91.6-1.8-2.0-1.61.8-1.8-1.81.61.2
Patch foraging total patch changes 6 sec2.44.14.52.0-2.01.9-2.02.02.12.0-2.0-2.1-2.02.0-2.1-2.12.01.9
Patch foraging time to switch 0 sec0.93.64.12.0-1.92.0-2.01.91.91.9-1.9-2.0-1.91.9-1.7-1.71.91.6
Patch foraging water rate 0 sec1.45.46.3-2.42.4-2.52.4-2.3-2.3-2.42.32.22.4-2.32.12.1-2.4-2.2
Patch foraging water rate 12 sec1.45.56.1-2.32.3-2.32.3-2.4-2.4-2.42.52.32.4-2.52.32.3-2.4-2.2
Patch foraging water rate 18 sec0.20.40.8-0.60.7-0.60.6-0.7-0.7-0.70.60.80.7-0.50.50.5-0.7-0.9
Patch foraging water rate 24 sec3.14.55.2-2.02.1-2.02.0-2.2-2.2-2.22.12.32.2-2.02.02.0-2.2-2.3
Patch foraging water rate 6 sec4.46.47.1-2.72.5-2.52.7-2.5-2.5-2.52.62.62.5-2.62.32.3-2.6-2.6
Seeking ratio, delayed vs. immediate footshock0.10.10.2-0.30.4-0.40.3-0.3-0.3-0.30.30.20.3-0.30.20.2-0.20.3
Distance traveled before self-admin0.40.91.11.0-1.01.0-1.00.91.00.9-1.0-0.9-0.91.0-1.0-1.00.80.4
Distance traveled after self-admin0.20.30.80.5-0.50.5-0.50.50.50.5-0.5-0.4-0.50.5-0.5-0.50.60.9
Extensor digitorum longus weight3.915.718.4-3.84.1-4.13.8-4.0-3.8-4.23.73.94.2-3.73.83.8-4.2-4.3
Bone: elastic displacement3.84.85.92.4-2.32.4-2.42.22.02.3-2.2-2.0-2.32.2-1.9-1.92.32.1
Bone: elastic work0.00.00.2-0.00.00.10.1-0.1-0.4-0.00.20.40.0-0.20.40.40.00.1
Bone: endosteal estimation7.418.019.4-4.44.2-4.24.4-4.3-4.3-4.24.34.24.2-4.34.34.3-4.2-3.8
Bone: endosteal perimeter6.315.517.5-4.24.0-4.14.1-4.0-3.8-4.03.93.74.0-3.93.83.8-4.0-3.7
Epididymis fat weight0.62.83.4-1.71.7-1.71.7-1.7-1.8-1.61.81.71.6-1.81.71.7-1.6-1.2
Delta time in closed arm before/after self-admin0.00.00.30.0-0.10.1-0.10.10.20.2-0.1-0.1-0.20.2-0.1-0.10.20.6
Delta time in open arm before/after self-admin0.81.01.21.1-1.01.1-1.01.01.01.0-1.1-1.0-1.01.1-1.0-1.00.90.6
Diff in mean of infusions in LGA sessions0.71.31.5-1.11.1-1.11.0-1.1-1.2-1.11.21.21.1-1.21.21.2-1.1-1.1
Delay discount exponential model param0.50.70.80.8-0.90.9-0.80.80.80.8-0.8-0.8-0.80.8-0.8-0.80.80.6
Extinction: sum of active levers before priming1.21.92.3-1.31.3-1.31.2-1.4-1.4-1.41.31.51.4-1.31.41.4-1.4-1.5
Active lever presses in extinction session 61.21.21.4-1.21.1-1.11.2-1.1-1.1-1.11.11.11.1-1.11.11.1-1.1-0.7
Bone: final force11.118.119.9-4.54.3-4.44.5-4.3-4.3-4.24.34.34.2-4.24.34.3-4.2-3.6
Bone: final moment12.219.621.5-4.64.5-4.54.6-4.4-4.5-4.44.54.54.4-4.44.54.5-4.3-3.6
Food consumed during 24 hour testing period1.02.02.5-1.61.5-1.51.5-1.4-1.5-1.41.51.41.4-1.51.41.4-1.3-0.7
Glucose0.10.20.7-0.20.5-0.40.1-0.5-0.4-0.60.30.30.6-0.30.40.4-0.6-0.8
Heart weight0.10.10.1-0.20.3-0.30.2-0.3-0.3-0.30.30.10.3-0.30.30.3-0.3-0.2
Delay discount hyperbolic model param0.50.60.80.8-0.90.9-0.80.80.80.8-0.8-0.8-0.80.8-0.8-0.80.80.6
Intermittent access intake day 1-15 change0.00.10.30.4-0.30.4-0.30.40.40.3-0.3-0.5-0.30.3-0.4-0.40.40.2
Intermittent access intake escalation0.00.00.10.1-0.10.1-0.10.10.20.10.0-0.3-0.10.0-0.1-0.10.10.0
Intermittent access intake escalation 20.10.20.40.4-0.40.4-0.40.40.50.4-0.3-0.6-0.40.4-0.6-0.60.40.3
Intermitt. access day 1 inactive lever presses0.11.01.51.2-1.11.2-1.21.00.91.0-1.2-0.8-1.01.1-0.8-0.80.90.6
Intermitt. access day 15 inactive lever presses0.31.51.71.3-1.21.2-1.31.21.21.2-1.2-1.2-1.21.2-1.3-1.31.21.2
Intermitt. access escalation Index0.20.60.8-0.60.8-0.70.7-0.8-0.8-0.90.70.80.9-0.70.80.8-0.9-0.9
Intermittent access day 1 total infusions0.41.31.51.0-1.21.0-1.11.21.21.2-1.2-1.2-1.21.2-1.2-1.21.11.2
Intermittent access day 15 total infusions0.51.21.81.0-1.11.0-1.11.11.31.0-1.1-1.3-1.01.1-1.2-1.21.00.7
Intermittent access terminal intake (last 3 days)0.91.62.31.1-1.31.1-1.21.31.51.3-1.3-1.5-1.31.2-1.4-1.41.31.0
Intermittent access total infusions1.92.23.11.4-1.51.3-1.41.51.71.4-1.6-1.7-1.41.5-1.6-1.61.41.1
Intermittent access day 1 locomotion0.00.10.20.3-0.30.3-0.30.30.30.3-0.4-0.3-0.30.4-0.3-0.30.20.1
Intermittent access day 15 total locomotion0.00.20.30.3-0.50.4-0.40.50.60.4-0.4-0.5-0.40.4-0.5-0.50.4-0.1
Intermittent access total locomotion1.21.41.71.1-1.31.1-1.11.21.31.2-1.3-1.3-1.21.2-1.3-1.31.10.6
Intermittent access standard deviation0.10.50.70.8-0.70.7-0.80.70.80.7-0.8-0.9-0.70.8-0.6-0.60.70.5
Left kidney weight0.43.64.9-2.02.0-2.22.1-1.9-1.9-1.92.01.81.9-1.91.81.8-1.8-1.2
Right kidney weight2.719.020.7-4.44.5-4.54.3-4.4-4.3-4.44.54.24.4-4.44.24.2-4.4-4.0
Cocaine induced anxiety1.43.94.8-1.92.0-1.91.9-2.0-2.0-2.11.91.92.1-1.91.81.8-2.1-2.2
Post-drug Anxiety2.93.33.7-1.81.9-1.81.8-1.9-1.9-1.91.91.91.9-1.91.61.6-1.9-1.6
Baseline Anxiety0.00.00.0-0.10.1-0.10.1-0.1-0.1-0.10.20.10.1-0.10.20.2-0.10.2
Tail length0.00.00.10.00.1-0.2-0.0-0.1-0.0-0.20.1-0.20.2-0.10.00.0-0.2-0.3
Length with tail1.66.97.6-2.62.7-2.72.6-2.7-2.5-2.72.62.42.8-2.62.62.6-2.8-2.6
Length without tail3.417.619.1-4.34.4-4.34.3-4.3-4.2-4.34.24.34.3-4.14.24.2-4.2-3.5
Times rat made contact with spout0.10.10.20.3-0.20.2-0.40.30.40.2-0.4-0.4-0.30.4-0.4-0.40.30.4
Lifetime Intake2.32.94.21.5-1.71.5-1.61.72.01.6-1.8-2.0-1.61.7-1.9-1.91.61.3
Liver weight, left9.616.618.2-4.24.1-4.34.2-4.1-3.9-4.14.13.94.1-4.04.04.0-4.1-3.9
Liver weight, right2.74.75.4-2.32.2-2.22.3-2.2-2.2-2.12.32.12.1-2.32.22.2-2.1-1.8
Locomotor activity1.21.82.61.2-1.41.2-1.21.41.51.4-1.4-1.3-1.31.4-1.6-1.61.30.7
Locomotor testing distance1.94.86.02.0-2.32.1-2.02.32.32.2-2.2-2.2-2.22.3-2.5-2.52.11.4
Locomotor testing rearing1.03.84.62.0-2.02.0-2.02.02.11.9-2.0-2.0-1.92.0-2.1-2.11.81.2
Locomotion in novel chamber1.21.61.9-1.21.3-1.31.2-1.3-1.2-1.31.21.31.3-1.21.21.2-1.4-1.4
Locomotion in novel chamber post-restriction0.00.00.10.2-0.20.2-0.20.20.20.2-0.1-0.1-0.20.1-0.2-0.20.20.3
Fecal boli incidents, locomotor time 11.02.63.11.6-1.51.5-1.71.61.71.6-1.6-1.6-1.61.6-1.6-1.61.61.8
Change in fecal boli incidents, locomotor task0.90.91.2-0.80.9-0.80.9-0.9-1.1-0.91.01.10.9-1.01.01.0-0.9-1.0
Time >=10cm from walls, locomotor time 10.00.00.1-0.20.3-0.20.2-0.2-0.3-0.20.30.20.2-0.30.20.2-0.2-0.0
Bouts of movement, locomotor time 10.00.00.00.10.00.1-0.1-0.0-0.10.00.10.0-0.0-0.10.10.10.0-0.2
Total resting periods, locomotor time 10.20.20.40.6-0.50.6-0.60.50.40.5-0.4-0.4-0.50.4-0.4-0.40.50.3
Rest time, locomotor task time 10.20.40.60.7-0.50.6-0.80.60.50.6-0.6-0.6-0.60.6-0.6-0.60.60.6
Distance moved, locomotor task time 10.00.00.1-0.20.1-0.10.1-0.2-0.2-0.10.20.20.1-0.20.30.3-0.1-0.1
Vertical activity count, locomotor time 10.21.41.8-1.31.3-1.31.3-1.2-1.1-1.21.31.11.2-1.21.11.1-1.2-0.8
Time >=10cm from walls, locomotor time 20.30.80.90.9-0.90.9-0.90.90.90.9-0.9-1.0-0.90.9-0.8-0.80.90.6
Bouts of movement, locomotor time 21.13.55.5-1.81.8-1.81.8-1.9-1.9-1.91.91.71.9-1.91.71.7-1.9-2.3
Total resting periods, locomotor time 21.03.85.9-1.81.9-1.91.9-2.0-2.0-2.02.01.82.0-2.01.81.8-2.0-2.4
Rest time, locomotor task time 20.00.00.10.20.1-0.0-0.2-0.1-0.1-0.1-0.00.00.10.0-0.0-0.0-0.1-0.3
Distance moved, locomotor task time 20.10.10.30.1-0.30.3-0.20.30.20.3-0.2-0.1-0.30.2-0.1-0.10.30.5
Vertical activity count, locomotor time 20.00.10.2-0.40.2-0.40.4-0.2-0.1-0.20.2-0.00.2-0.2-0.0-0.0-0.2-0.2
Light reinforcement 11.15.15.92.1-2.42.2-2.12.32.42.3-2.4-2.4-2.32.4-2.4-2.42.21.4
Light reinforcement 20.51.21.41.0-1.11.0-1.01.11.21.1-1.1-1.2-1.11.1-1.1-1.11.00.7
Bone: marrow area7.217.518.8-4.34.2-4.24.3-4.2-4.2-4.24.24.24.2-4.34.24.2-4.2-3.8
Bone: maximum diameter3.97.79.2-3.02.9-3.03.0-2.8-2.6-2.92.72.52.9-2.72.52.5-2.9-2.9
Bone: maximum force14.628.930.6-5.45.4-5.45.5-5.4-5.5-5.35.45.55.3-5.45.55.5-5.3-4.6
Bone: maximum moment16.030.332.7-5.65.5-5.55.7-5.5-5.7-5.45.65.75.4-5.65.75.7-5.4-4.5
Mean time between licks in bursts0.00.20.40.4-0.50.5-0.40.50.30.5-0.3-0.3-0.50.3-0.3-0.30.50.6
Mean num. licks in bursts0.00.10.9-0.10.10.00.10.0-0.20.10.20.2-0.1-0.10.20.20.21.0
Cd content in liver0.91.01.61.3-0.91.1-1.30.90.91.0-1.0-0.8-1.01.0-0.8-0.81.01.1
Co content in liver0.20.20.50.5-0.30.3-0.50.40.70.3-0.6-0.7-0.30.6-0.7-0.70.2-0.1
Cu content in liver1.21.51.7-1.21.3-1.21.2-1.3-1.2-1.31.11.21.3-1.11.21.2-1.3-1.2
Fe content in liver1.82.22.81.4-1.51.4-1.41.51.61.5-1.7-1.5-1.41.7-1.5-1.51.41.2
K content in liver0.00.00.2-0.30.2-0.20.2-0.2-0.0-0.2-0.00.10.20.00.10.1-0.3-0.4
Mg content in liver0.10.10.20.2-0.30.2-0.20.30.40.3-0.3-0.4-0.30.3-0.4-0.40.30.3
Mn content in liver0.00.00.00.0-0.10.1-0.10.0-0.10.10.10.1-0.1-0.10.10.10.0-0.1
Na content in liver0.00.00.10.3-0.10.2-0.30.10.20.0-0.3-0.1-0.00.3-0.1-0.1-0.0-0.3
Rb content in liver0.00.00.20.20.0-0.0-0.20.00.2-0.1-0.3-0.10.10.3-0.1-0.1-0.1-0.4
Se content in liver1.61.92.31.2-1.31.2-1.21.41.51.3-1.4-1.5-1.31.4-1.5-1.51.31.2
Sr content in liver1.71.41.7-1.31.2-1.21.3-1.2-1.1-1.31.21.11.3-1.21.11.1-1.3-1.3
Zn content in liver0.80.91.20.8-1.00.9-0.81.01.10.9-1.1-1.1-0.91.1-1.1-1.10.90.6
Bone: minimum diameter9.418.119.4-4.44.3-4.34.4-4.3-4.2-4.34.24.14.3-4.24.24.2-4.3-4.1
Time in familiar zone, hab. session 10.20.20.70.4-0.50.5-0.40.50.40.5-0.4-0.4-0.50.5-0.4-0.40.60.8
Time in novel zone, hab. session 10.30.31.0-0.60.5-0.60.6-0.5-0.5-0.60.50.50.6-0.50.40.4-0.6-1.0
Total zone transitions, hab. session 10.30.40.60.8-0.70.6-0.60.70.70.7-0.7-0.6-0.70.7-0.7-0.70.60.5
Total locomotion distance, hab. session 10.00.00.10.00.1-0.00.1-0.1-0.2-0.00.20.20.0-0.30.20.2-0.00.2
Locomotion velocity, hab. session 10.00.10.1-0.10.2-0.10.3-0.2-0.3-0.10.30.30.1-0.40.30.3-0.10.1
Time in familiar zone, hab. session 20.30.30.5-0.50.6-0.50.6-0.5-0.7-0.50.60.70.5-0.60.70.7-0.4-0.0
Time in novel zone, hab. session 20.20.20.30.4-0.50.4-0.40.40.50.4-0.5-0.5-0.40.5-0.5-0.50.3-0.2
Total zone transitions, hab. session 20.30.40.50.7-0.60.6-0.50.60.60.6-0.6-0.6-0.60.6-0.5-0.50.60.7
Total locomotion distance, hab. session 20.10.10.50.4-0.30.4-0.20.30.10.3-0.1-0.2-0.40.1-0.2-0.20.40.7
Locomotion velocity, hab. session 20.00.00.30.2-0.10.2-0.10.1-0.00.20.1-0.1-0.2-0.1-0.0-0.00.20.6
Novel to familiar place preference ratio1.52.03.0-1.31.4-1.41.3-1.4-1.4-1.51.21.41.5-1.31.41.4-1.5-1.7
Novelty place preference1.21.52.5-1.11.2-1.21.1-1.2-1.2-1.31.01.21.3-1.11.21.2-1.3-1.6
Time in novel zone, NPP test1.01.32.4-1.01.1-1.11.0-1.1-1.1-1.20.91.11.2-1.01.11.1-1.2-1.5
Total zone transitions, NPP test1.31.92.21.5-1.31.4-1.31.41.41.4-1.4-1.3-1.41.4-1.3-1.31.41.5
Total locomotion distance, NPP test1.62.23.01.6-1.51.6-1.41.51.41.6-1.3-1.4-1.61.3-1.4-1.41.61.7
Locomotion velocity, NPP test0.81.22.01.2-1.11.1-1.01.11.01.1-1.0-1.0-1.10.9-1.1-1.11.21.4
Intraocular pressure6.19.911.03.0-3.23.2-3.03.23.23.2-3.1-3.3-3.23.0-3.3-3.33.22.9
Delta distance traveled before/after self-admin0.00.00.5-0.10.0-0.10.1-0.0-0.10.00.20.1-0.0-0.20.10.10.10.7
Delta ambulatory time before/after self-admin0.00.00.30.1-0.20.1-0.20.20.20.2-0.1-0.3-0.20.1-0.2-0.20.20.5
Parametrial fat weight1.02.43.11.5-1.51.4-1.51.61.71.5-1.6-1.7-1.51.6-1.8-1.81.51.2
Pavlov. Cond. lever latency0.20.20.6-0.20.3-0.10.2-0.4-0.7-0.30.50.70.3-0.50.70.7-0.2-0.1
Pavlov. Cond. magazine entry latency0.00.10.30.0-0.20.20.00.20.20.2-0.1-0.2-0.20.2-0.2-0.20.30.5
Pavlov. Cond. change in total contacts0.00.00.1-0.30.2-0.20.2-0.10.1-0.2-0.0-0.10.20.0-0.1-0.1-0.2-0.2
Pavlov. Cond. index score0.00.00.1-0.20.2-0.20.2-0.10.1-0.2-0.0-0.20.20.0-0.2-0.2-0.2-0.3
Pavlov. Cond. latency score0.00.00.1-0.20.1-0.20.2-0.00.2-0.1-0.1-0.30.10.1-0.3-0.3-0.2-0.3
Pavlov. Cond. lever contacts0.50.61.00.6-0.70.5-0.70.71.00.6-0.9-1.0-0.60.9-1.0-1.00.60.4
Pavlov. Cond. magazine entry number0.00.00.00.00.0-0.1-0.0-0.1-0.2-0.10.10.20.1-0.10.20.2-0.1-0.2
Pavlov. Cond. intertrial magazine entries0.30.40.60.6-0.60.7-0.80.60.50.6-0.6-0.5-0.60.6-0.5-0.50.70.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.40.4-0.40.4-0.3-0.1-0.40.20.10.4-0.20.10.1-0.5-0.6
Pavlov. Cond. response bias0.10.20.30.3-0.40.4-0.30.40.50.4-0.4-0.5-0.40.5-0.5-0.50.40.5
Pavlov. Cond. lever latency0.10.10.2-0.40.3-0.30.4-0.3-0.4-0.30.30.40.3-0.30.50.5-0.3-0.4
Pavlov. Cond. magazine entry latency0.91.31.6-1.31.1-1.21.2-1.2-1.2-1.11.11.21.1-1.21.11.1-1.1-0.9
Pavlov. Cond. change in total contacts0.92.22.6-1.51.6-1.61.3-1.6-1.4-1.61.41.41.6-1.51.41.4-1.6-1.4
Pavlov. Cond. index score0.50.81.0-0.91.0-0.90.8-1.0-0.9-1.00.90.91.0-0.90.90.9-1.0-0.8
Pavlov. Cond. latency score0.40.70.8-0.90.9-0.90.8-0.9-0.8-0.90.80.80.9-0.80.80.8-0.9-0.7
Pavlov. Cond. lever contacts0.00.00.10.2-0.10.2-0.20.10.20.1-0.2-0.2-0.10.2-0.3-0.30.10.2
Pavlov. Cond. magazine entry number2.43.13.31.8-1.81.8-1.71.81.71.8-1.7-1.7-1.81.7-1.7-1.71.81.7
Pavlov. Cond. intertrial magazine entries4.08.89.12.8-3.02.9-2.93.03.03.0-3.0-3.0-3.03.0-3.0-3.03.02.9
Pavlov. Cond. lever-magazine prob. diff.0.81.21.3-1.11.1-1.11.0-1.1-1.1-1.11.01.11.1-1.11.01.0-1.1-1.0
Pavlov. Cond. response bias0.00.10.1-0.20.3-0.20.2-0.3-0.2-0.30.20.30.3-0.20.20.2-0.3-0.2
Time in closed arm before self-admin1.83.13.6-1.71.8-1.71.8-1.8-1.8-1.81.71.81.8-1.71.61.6-1.8-1.9
Time in closed arm after self-admin0.10.10.2-0.40.4-0.40.5-0.4-0.4-0.40.40.40.3-0.40.30.3-0.3-0.3
Time in open arm before self-admin0.00.00.10.2-0.20.2-0.30.20.20.2-0.1-0.3-0.20.1-0.1-0.10.2-0.1
Time in open arm after self-admin0.00.00.10.3-0.20.2-0.30.10.10.1-0.2-0.2-0.10.20.00.00.1-0.1
Bone: periosteal estimation11.928.231.2-5.65.4-5.55.6-5.4-5.2-5.45.35.15.4-5.35.15.1-5.4-4.9
Bone: periosteal perimeter9.819.321.8-4.74.5-4.64.6-4.5-4.3-4.44.44.34.4-4.44.34.3-4.4-3.8
Bone: post-yield work7.913.614.6-3.73.6-3.73.8-3.7-3.7-3.73.73.83.7-3.73.83.8-3.7-3.5
Progressive ratio test 1 active lever presses3.86.78.42.5-2.62.5-2.62.62.82.5-2.7-2.9-2.52.6-2.7-2.72.41.8
Progressive ratio test 1 breakpoint3.66.17.82.4-2.52.4-2.52.52.72.4-2.6-2.8-2.42.5-2.6-2.62.31.7
Progressive ratio test 1 inactive lever presses1.13.03.81.6-1.71.6-1.61.71.81.7-1.8-1.8-1.61.8-2.0-2.01.61.2
Progressive ratio test 2 active lever presses1.62.33.21.6-1.51.5-1.71.51.71.4-1.5-1.8-1.41.4-1.7-1.71.30.6
Progressive ratio test 2 breakpoint1.62.13.01.6-1.51.5-1.61.41.61.4-1.4-1.7-1.31.4-1.6-1.61.20.6
Progressive ratio test 2 inactive lever presses0.61.92.51.4-1.41.3-1.51.41.51.3-1.4-1.6-1.31.3-1.6-1.61.20.8
Incentive Sensitization - Responses0.10.20.7-0.50.4-0.50.4-0.4-0.3-0.50.60.20.5-0.60.20.2-0.5-0.9
Incentive Sensitization - Breakpoint0.10.10.6-0.30.3-0.40.3-0.3-0.2-0.40.50.10.4-0.50.10.1-0.4-0.8
Sum of active levers in priming session hrs 5-60.00.00.10.00.10.0-0.0-0.1-0.2-0.10.10.30.1-0.10.40.4-0.10.1
Progressive ratio0.10.30.60.4-0.50.4-0.40.60.60.6-0.4-0.7-0.60.4-0.7-0.70.60.8
Food seeking constrained by brief footshock0.81.01.21.0-1.01.0-1.01.01.11.0-1.1-1.0-0.91.1-1.1-1.10.90.9
Seeking ratio, punishment vs. effort0.00.00.10.2-0.10.2-0.20.10.10.1-0.20.1-0.00.20.00.00.0-0.1
Retroperitoneal fat weight0.31.41.51.1-1.11.0-1.21.21.21.2-1.2-1.2-1.21.2-1.2-1.21.21.1
Reaction time number correct0.62.12.7-1.51.4-1.31.6-1.4-1.6-1.31.61.61.3-1.61.51.5-1.3-1.1
Reaction time mean minus median1.811.812.33.4-3.43.4-3.43.43.43.4-3.4-3.4-3.43.4-3.5-3.53.53.5
Reaction time mean minus median AUC1.28.28.83.0-2.83.0-2.92.92.82.9-2.8-2.8-2.92.7-2.9-2.92.92.9
Reaction time num false alarms1.32.23.11.4-1.51.4-1.41.51.51.5-1.4-1.5-1.51.5-1.4-1.41.61.8
Reaction time num false alarms AUC1.53.35.21.8-1.81.8-1.81.81.81.9-1.7-1.8-1.91.8-1.7-1.71.92.3
Reaction time trials correct on left0.62.12.7-1.51.4-1.31.6-1.4-1.6-1.31.61.61.3-1.61.51.5-1.3-1.1
Reaction time trials on left0.51.62.1-1.31.2-1.11.4-1.2-1.4-1.21.41.41.1-1.51.31.3-1.1-0.9
Reaction time mean0.51.11.51.1-1.01.0-1.11.01.11.0-1.0-1.2-1.00.9-1.1-1.11.00.9
Reaction time mean AUC0.20.60.90.8-0.70.8-0.80.70.80.7-0.7-1.0-0.70.7-0.8-0.80.70.7
Median of all reaction times0.00.00.0-0.00.1-0.10.0-0.10.0-0.10.1-0.20.1-0.1-0.0-0.0-0.1-0.2
Reaction time omissions9.114.815.33.9-3.83.9-3.93.93.83.9-3.7-3.8-3.93.7-3.9-3.93.93.8
Reaction time false alarm rate2.73.74.71.9-1.91.8-2.01.92.01.9-1.9-2.0-1.92.0-1.9-1.92.02.2
Reaction time premature initiation rate5.07.79.72.8-2.82.6-2.72.82.92.7-2.9-2.8-2.72.9-3.1-3.12.62.1
Reaction time premature initiations1.23.54.71.8-1.91.8-1.81.92.01.9-1.9-1.8-1.91.8-2.2-2.21.81.4
Std. dev. reaction times2.89.39.63.1-3.03.1-3.13.03.13.0-3.0-3.1-3.03.0-3.1-3.13.13.0
Reaction time trials completed0.51.62.1-1.31.2-1.11.4-1.2-1.4-1.21.41.41.1-1.51.31.3-1.1-0.9
Reaction time trials AUC0.82.63.3-1.71.5-1.51.7-1.6-1.8-1.51.81.81.5-1.81.71.7-1.5-1.2
Run reversals in cocaine runway, females0.00.00.1-0.20.1-0.20.1-0.1-0.2-0.10.10.30.1-0.10.30.3-0.1-0.2
Run reversals in cocaine runway, males1.11.21.31.0-1.11.0-1.01.11.11.1-1.1-1.1-1.11.1-1.1-1.11.11.0
Latency to leave start box in cocaine runway0.00.00.10.1-0.20.1-0.10.20.20.2-0.2-0.4-0.20.2-0.2-0.20.20.2
Latency to leave start box in cocaine runway, F0.91.11.61.0-1.11.0-1.01.11.11.1-1.0-1.3-1.11.0-1.2-1.21.00.9
Latency to leave start box in cocaine runway, M1.71.61.8-1.41.3-1.41.3-1.3-1.3-1.31.31.21.3-1.31.31.3-1.2-0.9
Std. dev. time between licks in bursts0.61.21.61.1-1.11.0-1.01.11.21.0-1.1-1.3-1.01.0-1.3-1.31.00.7
Total sessions with >9 infusions2.22.74.41.5-1.61.4-1.51.71.91.6-1.7-2.1-1.51.6-2.0-2.01.51.1
Short access day 1 total inactive lever presses1.22.43.01.5-1.51.5-1.51.51.71.5-1.7-1.7-1.51.6-1.6-1.61.41.2
Short access day 10 total inactive lever presses0.00.20.30.6-0.40.5-0.50.40.30.4-0.5-0.1-0.40.5-0.3-0.30.40.3
Short access day 1 total infusions0.50.91.50.8-0.90.8-0.80.91.10.9-0.9-1.2-0.90.9-1.2-1.20.80.7
Short access day 10 total infusions1.21.92.91.2-1.31.1-1.21.41.71.3-1.5-1.7-1.31.5-1.5-1.51.30.9
Short access total infusions2.23.24.91.5-1.71.5-1.61.82.11.7-1.9-2.2-1.71.8-2.1-2.11.61.3
Short access day 1 locomotion0.10.20.40.4-0.40.3-0.40.40.60.4-0.5-0.6-0.30.5-0.7-0.70.3-0.0
Short access day 10 total locomotion0.10.30.40.5-0.60.6-0.50.50.60.5-0.7-0.5-0.50.6-0.5-0.50.40.1
Short access total locomotion0.71.01.31.0-1.01.0-1.01.01.10.9-1.1-1.1-0.91.1-1.1-1.10.80.4
One hour access (0.3 mA shock)0.20.20.40.2-0.30.2-0.30.40.60.3-0.4-0.7-0.30.4-0.6-0.60.30.0
Compulsive drug intake0.00.00.40.0-0.0-0.00.00.10.00.1-0.1-0.1-0.10.20.10.10.20.6
One hour access (shock baseline)0.00.00.2-0.10.0-0.10.00.00.2-0.00.0-0.20.0-0.0-0.4-0.4-0.1-0.4
Social response proportion0.20.20.30.5-0.40.4-0.50.40.40.4-0.4-0.4-0.30.5-0.6-0.60.40.5
Social responses7.59.810.93.2-3.13.1-3.23.13.23.1-3.2-3.0-3.13.2-3.3-3.33.02.7
Social time0.00.00.3-0.00.1-0.00.0-0.0-0.20.00.10.2-0.0-0.00.10.10.10.6
Soleus weight0.61.72.1-1.21.3-1.31.2-1.3-1.3-1.31.21.41.3-1.21.51.5-1.3-1.3
Bone: stiffness16.830.532.6-5.65.6-5.65.7-5.6-5.6-5.55.65.55.5-5.65.55.5-5.5-4.9
Tibialis anterior weight0.93.07.0-1.41.8-1.81.4-1.8-1.5-1.91.31.52.0-1.41.51.5-2.1-2.7
Time to tail flick, vehicle, before self-admin1.41.72.01.3-1.31.3-1.41.31.31.4-1.3-1.2-1.41.2-1.3-1.31.41.4
Time to tail flick, vehicle, after self-admin0.10.10.5-0.20.3-0.20.4-0.3-0.4-0.30.30.40.3-0.40.40.4-0.4-0.7
Time to tail flick, test, before self-admin0.20.30.40.6-0.50.7-0.50.50.40.6-0.5-0.4-0.60.4-0.2-0.20.60.6
Time to tail flick, test, after self-admin0.70.71.0-0.90.8-0.80.9-0.8-0.9-0.80.90.90.8-1.00.90.9-0.7-0.6
Delta time to tail flick, vehicle, before/after SA0.50.50.6-0.70.7-0.70.8-0.7-0.7-0.80.70.70.8-0.70.70.7-0.8-0.7
Delta time to tail flick, test, before/after SA0.20.30.4-0.60.5-0.70.6-0.5-0.5-0.50.50.50.5-0.50.20.2-0.5-0.3
Tibia length7.621.122.9-4.64.7-4.84.7-4.7-4.5-4.74.64.44.7-4.54.54.5-4.7-4.4
Ambulatory time before self-admin0.82.53.01.7-1.61.7-1.71.61.61.6-1.7-1.4-1.61.7-1.6-1.61.51.0
Ambulatory time after self-admin0.81.31.51.2-1.21.2-1.21.21.21.1-1.2-1.2-1.11.2-1.2-1.21.10.9
Bone: tissue strength1.11.21.8-0.91.0-0.90.9-1.1-1.3-1.01.11.31.0-1.11.41.4-1.0-0.9
Total heroin consumption1.11.33.4-1.01.0-1.00.9-1.1-1.0-1.10.91.11.1-0.91.21.2-1.2-1.8
Bone: trabecular number5.310.112.0-3.33.2-3.33.3-3.2-3.3-3.13.53.33.1-3.43.23.2-3.0-1.9
Bone: trabecular spacing2.13.13.71.7-1.81.7-1.71.81.91.7-1.9-1.9-1.71.9-1.9-1.91.60.7
Bone: trabecular thickness0.10.10.30.2-0.20.2-0.30.30.30.3-0.2-0.4-0.30.2-0.3-0.30.30.5
Bone: trabecular tissue density0.00.00.1-0.1-0.20.1-0.00.10.10.1-0.1-0.2-0.10.0-0.0-0.00.0-0.4
Water consumed over 24 hours0.10.10.1-0.40.3-0.30.4-0.3-0.4-0.30.40.40.3-0.40.40.4-0.2-0.0
Number of responses in last shaping day0.10.10.20.4-0.30.3-0.40.20.40.1-0.3-0.4-0.10.2-0.4-0.40.1-0.4