Hub : Genes

Ppwd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA alternative TSS XM_063281507.1 0.03 0.03 9.7e-03 0.01 -0 0 -0 5.4e-02 8.5e-01 1.6e-01 7.8e-01
2 Liver isoform ratio XM_063281507.1 0.02 0.02 7.7e-03 0.01 0.01 0 0.01 3.3e-02 3.4e-02 1.3e-01 6.3e-02
3 BLA alternative polyA XM_063281506.1 0.06 0.06 5.3e-03 0.03 0.03 0.03 0.01 7.5e-03 1.5e-02 9.8e-03 1.5e-01
4 LHb alternative TSS XM_063281506.1 0.15 0.12 6.3e-03 0.04 0.04 0.01 0.02 4.8e-02 3.3e-02 2.1e-01 8.8e-02
5 Liver alternative polyA XM_063281506.1 0.04 0.04 2.4e-04 0.02 0.02 0.02 0.02 2.1e-03 1.1e-03 2.4e-03 3.3e-03
6 Liver alternative polyA NM_001106406.1 0.03 0.03 1.7e-03 0.01 0.02 0.01 0.01 8.3e-03 5.8e-03 1.0e-02 1.5e-02
7 Liver alternative polyA XM_063281506.1 0.03 0.03 8.3e-04 0.02 0.02 0.02 0.01 5.0e-03 2.9e-03 5.6e-03 8.1e-03
8 IC intron excision ratio chr2_37090704_37093909 0.08 0.08 8.6e-03 0.04 0.01 0 0.02 8.8e-03 7.8e-02 2.4e-01 4.9e-02
9 BLA alternative polyA NM_001106406.1 0.06 0.06 4.4e-03 0.03 0.02 0.01 0.02 1.5e-02 3.4e-02 1.5e-01 3.4e-02
10 BLA alternative polyA XM_063281506.1 0.06 0.06 4.0e-03 0.03 0.02 0.02 0.02 1.1e-02 3.3e-02 4.3e-02 2.7e-02
11 pVTA alternative polyA XM_063281506.1 0.03 0.03 6.0e-03 0.02 -0 0.02 -0 4.3e-03 3.8e-01 6.2e-03 5.8e-01
12 LHb isoform ratio XM_063281506.1 0.26 0.21 9.1e-04 0.11 0.07 0.05 0.01 1.8e-03 8.5e-03 2.1e-02 1.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.61.11.4-1.11.11.0-1.01.0-1.01.01.0-1.01.00.9-1.2
Area under the delay curve0.40.50.70.5-0.1-0.90.7-0.70.7-0.7-0.80.9-0.9-0.20.6
BMI with tail2.17.18.1-2.72.92.5-2.62.7-2.72.72.5-2.62.62.8-2.7
BMI without tail0.41.21.9-1.41.41.0-1.11.1-1.11.10.9-1.01.01.3-1.1
Body weight3.716.317.04.0-4.1-4.14.1-4.14.1-4.1-4.14.0-4.0-3.83.9
Weight adjusted by age0.00.10.20.3-0.5-0.20.2-0.20.2-0.20.20.1-0.1-0.20.4
Bone surface0.00.00.00.00.0-0.10.0-0.00.0-0.0-0.10.0-0.00.0-0.1
Bone volume0.00.10.1-0.30.30.2-0.20.2-0.20.20.2-0.20.20.2-0.4
Breakpoint value in progressive ratio session3.13.74.4-1.81.71.9-1.81.9-1.91.92.0-2.12.12.0-2.1
Number of licking bursts2.13.43.9-1.81.81.8-1.81.8-1.81.81.8-1.91.92.0-1.7
Context. condit. distance diff. score1.72.12.51.5-1.5-1.41.5-1.51.5-1.5-1.61.5-1.5-1.11.3
Locomotion velocity, session 10.30.30.60.8-0.7-0.60.6-0.60.6-0.6-0.60.5-0.5-0.40.3
Locomotion distance, session 10.70.91.11.0-0.9-1.01.0-1.01.0-1.0-1.10.9-0.9-0.90.8
Locomotion velocity, session 24.14.85.12.3-2.2-2.32.2-2.22.2-2.2-2.22.2-2.2-2.12.0
Locomotion distance, session 20.71.01.31.1-1.1-1.11.0-1.01.0-1.0-1.11.0-1.0-0.80.7
Locomotion velocity, session 35.15.87.02.6-2.7-2.42.4-2.42.4-2.4-2.32.2-2.2-2.42.4
Locomotion distance, session 37.58.18.83.0-3.0-2.92.9-2.92.9-2.9-2.82.8-2.8-2.82.8
Stereotopy head waving bouts, day 30.20.20.60.4-0.3-0.30.4-0.40.4-0.4-0.40.4-0.4-0.80.6
Stereotopy head waving duration, day 30.00.10.1-0.20.20.3-0.30.2-0.20.20.3-0.30.3-0.0-0.1
Locomotion velocity, session 70.10.10.20.3-0.3-0.20.2-0.20.2-0.2-0.20.1-0.1-0.40.4
Locomotion distance, session 70.30.40.60.6-0.7-0.70.7-0.70.7-0.7-0.60.6-0.6-0.80.6
Stereotopy head waving bouts, day 70.00.00.00.00.10.2-0.10.1-0.10.10.2-0.20.2-0.10.1
Stereotopy head waving duration, day 70.10.10.30.3-0.2-0.20.3-0.30.3-0.3-0.20.2-0.2-0.60.5
Locomotion velocity, session 82.32.83.41.8-1.8-1.71.7-1.71.7-1.7-1.71.6-1.6-1.51.4
Locomotion distance, session 84.46.47.22.6-2.6-2.52.6-2.62.6-2.6-2.72.6-2.6-2.22.2
Degree of sensitization distance3.83.94.7-2.22.21.9-2.02.0-2.02.01.9-1.91.91.7-1.9
Degree of sensitization stereotypy0.00.00.1-0.00.10.2-0.20.2-0.20.20.2-0.30.30.1-0.1
Conditioned locomotion0.00.00.00.1-0.00.1-0.00.0-0.00.00.2-0.10.1-0.20.1
Cocaine response after cond. corrected1.72.02.31.4-1.3-1.41.4-1.41.4-1.4-1.41.4-1.4-1.41.5
Cocaine response after cond. not corrected2.32.72.91.6-1.5-1.71.7-1.71.7-1.7-1.61.7-1.7-1.61.6
Cocaine response before conditioning0.30.30.50.6-0.6-0.60.6-0.60.6-0.6-0.70.6-0.6-0.50.2
Saline control response1.21.62.01.3-1.4-1.31.3-1.31.3-1.3-1.31.3-1.3-1.11.0
Bone: connectivity density0.10.10.1-0.30.30.2-0.30.3-0.30.30.2-0.30.30.2-0.4
Bone: cortical apparent density0.00.00.00.1-0.0-0.10.1-0.10.1-0.1-0.10.1-0.1-0.20.2
Bone: cortical area0.10.20.40.4-0.4-0.40.5-0.50.5-0.5-0.40.4-0.4-0.60.4
Bone: cortical porosity2.62.83.3-1.51.61.7-1.61.6-1.61.61.7-1.71.71.8-1.7
Bone: cortical porosity2.42.72.9-1.51.51.7-1.61.6-1.61.61.7-1.71.71.7-1.6
Bone: cortical thickness0.10.10.40.2-0.1-0.30.3-0.30.3-0.3-0.20.2-0.2-0.60.4
Bone: cortical thickness1.21.41.61.2-1.2-1.31.2-1.21.2-1.2-1.21.2-1.2-0.81.0
Bone: cortical tissue density0.00.00.10.1-0.1-0.10.1-0.10.1-0.1-0.10.1-0.1-0.20.2
Condit. Reinf. active minus inactive responses1.71.92.5-1.61.51.5-1.41.4-1.41.41.5-1.41.40.9-1.0
Condit. Reinf. active-inactive response ratio1.81.92.5-1.51.51.6-1.41.4-1.41.41.6-1.41.40.9-0.9
Condit. Reinf. active responses0.20.30.4-0.60.60.6-0.60.5-0.50.50.6-0.50.50.1-0.2
Condit. Reinf. inactive responses1.21.51.81.3-1.3-1.21.2-1.21.2-1.2-1.31.2-1.2-1.11.1
Incentive salience index mean1.11.41.8-1.31.31.3-1.21.2-1.21.21.3-1.21.20.9-0.8
Condit. Reinf. lever presses0.20.20.3-0.50.50.5-0.50.5-0.50.50.5-0.50.50.5-0.3
Condit. Reinf. active minus inactive responses4.45.76.92.6-2.6-2.32.4-2.42.4-2.4-2.32.3-2.3-2.22.4
Condit. Reinf. active-inactive response ratio2.22.63.01.7-1.7-1.51.6-1.61.6-1.6-1.51.6-1.6-1.61.7
Condit. Reinf. active responses1.52.12.81.6-1.7-1.31.5-1.41.4-1.4-1.41.4-1.4-1.31.4
Condit. Reinf. inactive responses0.10.10.20.4-0.4-0.30.3-0.30.3-0.3-0.30.3-0.3-0.20.2
Condit. Reinf. lever presses1.92.63.21.7-1.7-1.51.6-1.61.6-1.6-1.51.6-1.6-1.61.8
Condit. Reinf. lever reinforcers received2.02.83.61.9-1.9-1.51.7-1.71.7-1.7-1.61.6-1.6-1.51.7
Conditioned reinforcement - actives2.13.65.02.0-2.2-2.11.8-1.81.8-1.8-1.61.8-1.8-2.11.6
Conditioned reinforcement - inactives1.01.53.11.0-1.0-1.31.1-1.21.2-1.2-1.01.2-1.2-1.81.3
Conditioned locomotion0.81.01.51.2-1.2-1.01.0-1.01.0-1.0-0.71.0-1.0-1.20.9
Patch foraging indifference point 0 sec3.76.88.12.3-2.4-2.62.5-2.62.6-2.6-2.52.7-2.7-2.72.8
Patch foraging indifference point AUC0.30.51.2-0.50.50.5-0.70.7-0.70.70.6-0.60.61.1-0.9
Delay disc. indifference point, 0s delay0.40.50.7-0.80.90.5-0.60.6-0.60.60.8-0.70.70.6-0.7
Delay disc. indifference point, 16s delay1.21.41.81.2-0.9-1.21.2-1.21.2-1.2-1.31.3-1.3-0.91.1
Delay disc. indifference point, 2s delay0.20.20.4-0.40.70.2-0.40.4-0.40.40.5-0.40.40.5-0.6
Delay disc. indifference point, 24s delay1.01.21.50.9-0.7-1.11.1-1.11.1-1.1-1.21.2-1.2-0.91.2
Delay disc. indifference point, 4s delay0.00.00.1-0.20.4-0.30.1-0.10.1-0.1-0.20.2-0.20.10.0
Delay disc. indifference point, 8s delay0.20.20.30.20.3-0.60.4-0.40.4-0.4-0.50.5-0.50.20.4
Indifference point function ln k2.95.06.02.2-2.2-2.22.2-2.22.2-2.2-2.22.2-2.2-2.52.3
Indifference point function log k2.95.06.02.2-2.2-2.22.2-2.22.2-2.2-2.22.2-2.2-2.52.3
Patch foraging total patch changes 0 sec4.38.19.32.6-2.7-2.92.8-2.82.8-2.8-2.73.0-3.0-3.03.1
Patch foraging total patch changes 12 sec0.00.00.1-0.10.1-0.30.1-0.10.1-0.1-0.20.1-0.10.1-0.0
Patch foraging total patch changes 18 sec0.00.00.0-0.1-0.1-0.20.0-0.00.0-0.00.20.1-0.10.10.1
Patch foraging total patch changes 24 sec0.71.11.50.9-0.8-1.11.0-1.11.1-1.1-1.01.2-1.2-1.01.1
Patch foraging total patch changes 6 sec0.91.41.80.8-0.9-1.41.2-1.21.2-1.2-1.11.3-1.3-1.11.3
Patch foraging time to switch 0 sec4.49.09.8-3.13.12.9-3.03.0-3.03.03.1-3.03.02.9-2.9
Patch foraging water rate 0 sec3.57.38.02.6-2.6-2.72.7-2.72.7-2.7-2.82.8-2.8-2.72.6
Patch foraging water rate 12 sec3.47.17.52.6-2.6-2.52.7-2.72.7-2.7-2.62.7-2.7-2.72.7
Patch foraging water rate 18 sec5.48.49.02.9-2.7-2.92.9-2.92.9-2.9-3.03.0-3.0-3.02.7
Patch foraging water rate 24 sec2.53.54.01.9-1.9-2.01.9-1.91.9-1.9-1.81.8-1.8-2.01.6
Patch foraging water rate 6 sec13.019.020.14.3-4.3-4.24.4-4.44.4-4.4-4.44.5-4.5-4.54.1
Seeking ratio, delayed vs. immediate footshock0.91.11.6-1.00.90.9-1.11.1-1.11.10.9-1.01.01.2-1.2
Distance traveled before self-admin0.81.11.90.8-0.8-1.01.0-1.01.0-1.0-1.31.4-1.4-0.90.8
Distance traveled after self-admin1.31.72.01.2-1.1-1.31.3-1.31.3-1.3-1.41.4-1.4-1.01.3
Extensor digitorum longus weight3.915.116.2-3.93.73.8-3.93.9-3.93.93.8-3.93.94.0-4.0
Bone: elastic displacement1.92.22.5-1.51.61.5-1.51.5-1.51.51.5-1.51.51.5-1.3
Bone: elastic work0.50.60.8-0.90.90.7-0.80.8-0.80.80.7-0.80.80.7-0.7
Bone: endosteal estimation0.40.91.00.9-0.9-1.01.0-0.90.9-1.0-1.01.0-1.0-0.90.8
Bone: endosteal perimeter0.00.00.10.2-0.2-0.20.2-0.20.2-0.2-0.20.2-0.2-0.20.1
Epididymis fat weight0.93.03.71.7-1.7-1.61.7-1.81.8-1.7-1.41.7-1.7-1.91.9
Delta time in closed arm before/after self-admin3.23.04.0-1.71.71.8-1.71.8-1.81.81.7-1.71.72.0-1.6
Delta time in open arm before/after self-admin0.20.20.4-0.40.40.4-0.40.4-0.40.40.4-0.40.40.3-0.7
Diff in mean of infusions in LGA sessions0.00.00.00.1-0.00.10.0-0.00.0-0.00.0-0.00.00.1-0.2
Delay discount exponential model param0.40.50.8-0.50.10.9-0.70.7-0.70.70.8-0.90.90.2-0.7
Extinction: sum of active levers before priming2.73.03.6-1.71.71.8-1.71.7-1.71.71.9-1.91.91.5-1.5
Active lever presses in extinction session 63.13.13.9-1.51.51.8-1.71.8-1.81.81.8-1.91.92.0-1.8
Bone: final force0.40.70.80.8-0.8-0.90.8-0.80.8-0.8-0.90.9-0.9-0.90.8
Bone: final moment0.71.11.21.0-1.0-1.11.0-1.01.0-1.0-1.11.0-1.0-1.11.0
Food consumed during 24 hour testing period0.91.21.51.0-1.0-1.21.1-1.11.1-1.1-1.21.0-1.0-1.21.0
Glucose0.30.40.8-0.90.90.7-0.70.7-0.70.70.7-0.50.50.2-0.4
Heart weight0.71.21.50.9-1.2-1.01.0-1.01.0-1.0-0.91.2-1.2-1.21.1
Delay discount hyperbolic model param0.40.40.7-0.50.10.8-0.70.6-0.60.60.7-0.80.80.2-0.6
Intermittent access intake day 1-15 change0.00.00.1-0.2-0.10.1-0.10.1-0.10.10.3-0.20.2-0.4-0.1
Intermittent access intake escalation0.00.10.30.1-0.4-0.20.2-0.30.3-0.2-0.10.2-0.2-0.60.2
Intermittent access intake escalation 20.20.30.5-0.50.20.6-0.50.5-0.50.50.7-0.60.60.2-0.7
Intermitt. access day 1 inactive lever presses0.41.42.1-1.31.21.2-1.21.2-1.21.21.5-1.31.30.7-0.9
Intermitt. access day 15 inactive lever presses0.51.11.5-1.11.10.9-1.01.0-1.01.01.1-0.90.90.9-1.2
Intermitt. access escalation Index0.20.30.60.8-0.6-0.50.6-0.60.6-0.6-0.60.4-0.4-0.40.5
Intermittent access day 1 total infusions1.32.12.81.7-1.5-1.51.4-1.41.4-1.4-1.21.3-1.3-1.61.4
Intermittent access day 15 total infusions2.23.35.01.8-2.0-1.81.7-1.81.8-1.8-1.61.7-1.7-2.21.8
Intermittent access terminal intake (last 3 days)1.41.93.11.4-1.7-1.41.3-1.31.3-1.3-1.11.2-1.2-1.81.2
Intermittent access total infusions3.54.25.42.1-2.2-2.22.0-2.02.0-2.0-1.82.0-2.0-2.31.9
Intermittent access day 1 locomotion2.53.24.72.0-2.0-1.71.7-1.71.7-1.7-1.61.6-1.6-2.21.7
Intermittent access day 15 total locomotion2.13.75.42.0-2.1-1.91.9-1.91.9-1.9-1.61.9-1.9-2.31.8
Intermittent access total locomotion4.95.98.12.6-2.7-2.42.4-2.42.4-2.4-2.12.4-2.4-2.82.2
Intermittent access standard deviation0.00.00.1-0.2-0.0-0.0-0.20.2-0.20.20.4-0.20.20.3-0.3
Left kidney weight2.712.313.13.5-3.5-3.53.5-3.53.5-3.5-3.53.5-3.5-3.53.6
Right kidney weight2.611.912.73.6-3.6-3.33.4-3.43.4-3.4-3.43.5-3.5-3.53.5
Cocaine induced anxiety0.81.11.41.0-1.1-1.11.1-1.11.1-1.1-1.11.1-1.1-0.61.2
Post-drug Anxiety0.60.70.90.7-0.8-0.90.8-0.80.8-0.8-1.00.9-0.9-0.30.9
Baseline Anxiety0.10.10.2-0.40.40.3-0.30.3-0.30.30.2-0.20.20.3-0.4
Tail length10.038.940.46.1-6.1-6.26.3-6.36.3-6.3-6.36.2-6.2-6.46.2
Length with tail15.366.471.28.2-8.4-8.18.2-8.28.2-8.2-8.18.1-8.1-8.08.0
Length without tail10.935.239.76.2-6.3-5.96.0-6.06.0-6.0-5.95.8-5.8-5.75.8
Times rat made contact with spout0.40.40.5-0.60.70.6-0.60.6-0.60.60.6-0.70.70.7-0.6
Lifetime Intake2.93.54.61.9-1.9-2.01.8-1.81.8-1.8-1.71.8-1.8-2.21.8
Liver weight, left5.08.311.62.6-2.6-2.72.8-2.92.9-2.9-2.92.8-2.8-3.43.0
Liver weight, right0.10.10.50.0-0.0-0.20.2-0.20.2-0.2-0.40.2-0.2-0.70.7
Locomotor activity0.30.50.70.8-0.8-0.60.7-0.70.7-0.7-0.60.8-0.8-0.50.7
Locomotor testing distance0.20.30.6-0.60.60.7-0.60.6-0.60.60.6-0.40.40.6-0.4
Locomotor testing rearing0.10.20.6-0.50.40.7-0.50.5-0.50.50.6-0.30.30.5-0.3
Locomotion in novel chamber0.71.01.6-1.00.91.0-0.90.9-0.90.90.9-0.90.91.2-1.1
Locomotion in novel chamber post-restriction0.00.00.1-0.20.20.1-0.10.1-0.10.1-0.1-0.20.20.3-0.3
Fecal boli incidents, locomotor time 11.11.62.1-1.01.01.4-1.31.3-1.31.31.4-1.41.40.9-1.0
Change in fecal boli incidents, locomotor task0.10.10.2-0.30.3-0.0-0.10.1-0.10.1-0.30.0-0.00.4-0.4
Time >=10cm from walls, locomotor time 12.12.22.5-1.61.41.6-1.61.6-1.61.61.3-1.51.51.2-1.4
Bouts of movement, locomotor time 10.30.40.6-0.50.60.7-0.60.6-0.60.60.8-0.60.60.7-0.6
Total resting periods, locomotor time 10.00.00.1-0.00.10.2-0.20.2-0.20.20.3-0.20.20.2-0.1
Rest time, locomotor task time 10.60.81.1-0.60.71.1-0.90.9-1.00.90.8-0.70.71.0-0.9
Distance moved, locomotor task time 10.81.21.60.9-1.0-1.31.2-1.21.2-1.2-1.11.0-1.0-1.11.0
Vertical activity count, locomotor time 10.30.61.20.7-0.7-1.10.9-0.90.9-0.9-0.80.7-0.7-0.40.4
Time >=10cm from walls, locomotor time 20.71.11.8-1.31.31.0-1.11.1-1.11.10.7-0.90.90.9-1.1
Bouts of movement, locomotor time 20.10.20.30.4-0.4-0.50.4-0.40.4-0.4-0.40.5-0.5-0.0-0.1
Total resting periods, locomotor time 20.00.00.3-0.10.00.0-0.00.1-0.10.10.10.1-0.10.4-0.5
Rest time, locomotor task time 23.03.84.7-1.71.82.2-2.02.0-2.02.02.1-2.02.01.8-1.8
Distance moved, locomotor task time 21.31.52.31.2-1.3-1.51.3-1.31.3-1.3-1.31.1-1.1-0.90.9
Vertical activity count, locomotor time 20.10.10.40.2-0.2-0.60.4-0.40.4-0.4-0.30.1-0.1-0.10.0
Light reinforcement 11.94.65.22.3-2.3-1.92.0-2.02.0-2.0-2.12.2-2.2-2.32.2
Light reinforcement 20.10.10.2-0.10.30.5-0.40.4-0.40.40.4-0.40.4-0.0-0.2
Bone: marrow area0.40.91.00.9-0.9-1.01.0-0.90.9-0.9-1.01.0-1.0-0.90.8
Bone: maximum diameter0.20.40.6-0.60.60.6-0.60.6-0.60.60.7-0.70.70.5-0.8
Bone: maximum force0.10.20.30.4-0.4-0.50.5-0.50.5-0.5-0.50.5-0.5-0.60.5
Bone: maximum moment0.30.60.70.7-0.7-0.80.8-0.80.8-0.8-0.80.8-0.8-0.80.8
Mean time between licks in bursts0.10.20.4-0.60.60.2-0.40.4-0.40.40.3-0.40.40.3-0.3
Mean num. licks in bursts1.42.22.61.4-1.4-1.51.5-1.51.5-1.5-1.51.5-1.5-1.61.4
Cd content in liver1.92.13.01.3-1.3-1.41.4-1.41.4-1.4-1.41.4-1.4-1.71.7
Co content in liver0.00.00.0-0.10.10.1-0.10.1-0.10.10.1-0.10.10.1-0.1
Cu content in liver0.10.10.30.1-0.1-0.10.2-0.20.2-0.2-0.10.1-0.1-0.50.5
Fe content in liver1.21.41.51.2-1.2-1.21.2-1.21.2-1.2-1.21.2-1.2-1.21.1
K content in liver1.41.31.81.3-1.3-1.21.2-1.21.1-1.2-1.21.2-1.2-0.60.6
Mg content in liver0.10.10.20.3-0.3-0.20.1-0.10.1-0.1-0.20.2-0.20.4-0.5
Mn content in liver0.50.50.60.8-0.8-0.70.7-0.70.7-0.7-0.70.7-0.7-0.80.6
Na content in liver0.00.00.2-0.10.10.1-0.10.1-0.10.10.1-0.20.2-0.0-0.4
Rb content in liver1.61.92.91.4-1.4-1.21.3-1.31.3-1.3-1.21.3-1.3-1.71.6
Se content in liver0.81.01.3-1.01.00.9-0.90.9-0.90.90.9-1.01.01.1-1.1
Sr content in liver2.42.02.7-1.41.41.4-1.41.4-1.41.41.4-1.41.41.4-1.6
Zn content in liver0.10.20.20.4-0.4-0.40.4-0.40.4-0.4-0.40.4-0.4-0.20.4
Bone: minimum diameter2.54.55.32.0-2.0-2.12.2-2.22.2-2.2-2.12.1-2.1-2.32.1
Time in familiar zone, hab. session 14.44.24.42.1-2.1-2.02.1-2.12.1-2.1-2.02.1-2.1-2.02.1
Time in novel zone, hab. session 16.46.46.6-2.52.52.5-2.52.5-2.52.52.5-2.62.62.5-2.5
Total zone transitions, hab. session 10.00.00.00.2-0.2-0.20.1-0.10.1-0.1-0.20.1-0.10.2-0.2
Total locomotion distance, hab. session 10.10.20.40.6-0.6-0.40.4-0.30.3-0.3-0.40.5-0.50.1-0.0
Locomotion velocity, hab. session 10.10.10.30.6-0.6-0.30.3-0.30.3-0.3-0.30.4-0.40.1-0.1
Time in familiar zone, hab. session 21.92.02.31.5-1.5-1.41.4-1.41.4-1.4-1.31.5-1.5-1.31.4
Time in novel zone, hab. session 22.42.52.7-1.61.61.5-1.61.6-1.61.61.5-1.61.61.4-1.6
Total zone transitions, hab. session 20.10.10.20.5-0.4-0.40.3-0.30.3-0.3-0.40.2-0.20.0-0.0
Total locomotion distance, hab. session 20.00.00.20.2-0.2-0.0-0.00.0-0.10.1-0.1-0.00.00.4-0.4
Locomotion velocity, hab. session 20.10.10.30.5-0.5-0.30.3-0.30.3-0.3-0.40.3-0.30.1-0.1
Novel to familiar place preference ratio2.22.42.9-1.71.71.6-1.61.6-1.61.61.5-1.61.61.3-1.2
Novelty place preference1.71.82.2-1.51.51.4-1.41.4-1.31.41.4-1.41.41.1-1.1
Time in novel zone, NPP test1.92.02.3-1.51.51.5-1.41.4-1.41.41.4-1.51.51.2-1.2
Total zone transitions, NPP test1.42.02.51.6-1.5-1.41.4-1.41.4-1.4-1.51.5-1.5-1.11.2
Total locomotion distance, NPP test0.20.20.50.7-0.6-0.40.5-0.40.4-0.4-0.50.5-0.5-0.10.2
Locomotion velocity, NPP test0.71.01.51.2-1.1-1.01.0-1.01.0-1.0-1.01.0-1.0-0.60.8
Intraocular pressure3.95.66.8-2.32.22.6-2.42.4-2.42.42.6-2.62.61.6-2.0
Delta distance traveled before/after self-admin0.80.91.21.1-1.0-1.01.0-1.01.0-1.0-0.90.7-0.7-0.81.1
Delta ambulatory time before/after self-admin0.81.01.41.2-1.0-1.01.0-1.01.0-1.0-1.10.8-0.8-0.91.1
Parametrial fat weight0.00.00.10.0-0.1-0.30.2-0.20.2-0.2-0.20.2-0.2-0.20.3
Pavlov. Cond. lever latency0.00.00.0-0.10.10.1-0.10.1-0.10.10.0-0.10.10.1-0.1
Pavlov. Cond. magazine entry latency1.82.43.01.6-1.5-1.71.6-1.61.6-1.6-1.61.7-1.7-1.11.2
Pavlov. Cond. change in total contacts3.53.74.01.9-1.9-2.01.9-2.01.9-2.0-1.91.9-1.9-1.91.9
Pavlov. Cond. index score0.60.81.00.9-0.9-1.00.9-0.90.9-0.9-0.91.0-1.0-0.70.7
Pavlov. Cond. latency score0.20.30.40.5-0.5-0.60.5-0.50.5-0.5-0.50.6-0.6-0.40.5
Pavlov. Cond. lever contacts0.60.70.80.9-0.9-0.90.9-0.90.9-0.9-0.80.8-0.8-0.80.8
Pavlov. Cond. magazine entry number3.13.94.7-2.02.02.2-2.02.0-2.02.02.0-2.12.11.6-1.6
Pavlov. Cond. intertrial magazine entries5.66.77.4-2.62.62.7-2.62.6-2.62.62.7-2.72.72.3-2.4
Pavlov. Cond. lever-magazine prob. diff.0.91.11.31.0-1.0-1.11.1-1.11.1-1.1-1.01.1-1.1-0.90.9
Pavlov. Cond. response bias2.63.23.91.9-1.9-2.01.8-1.81.8-1.8-1.81.9-1.9-1.51.5
Pavlov. Cond. lever latency2.83.84.3-1.91.91.9-1.91.9-1.91.92.0-2.02.01.9-2.1
Pavlov. Cond. magazine entry latency1.11.31.61.3-1.3-1.21.2-1.21.2-1.2-1.21.1-1.1-0.61.0
Pavlov. Cond. change in total contacts4.67.48.02.7-2.7-2.72.7-2.72.7-2.7-2.82.8-2.8-2.52.7
Pavlov. Cond. index score2.63.54.01.9-1.9-1.91.9-1.91.9-1.9-2.01.9-1.9-1.51.9
Pavlov. Cond. latency score2.73.54.01.9-1.9-1.91.9-1.91.9-1.9-2.01.9-1.9-1.51.9
Pavlov. Cond. lever contacts2.12.93.41.6-1.6-1.61.7-1.71.7-1.7-1.71.7-1.7-1.71.9
Pavlov. Cond. magazine entry number2.12.63.3-1.81.81.7-1.71.6-1.61.71.8-1.61.61.0-1.4
Pavlov. Cond. intertrial magazine entries0.00.00.20.2-0.20.10.1-0.10.1-0.10.10.1-0.1-0.50.2
Pavlov. Cond. lever-magazine prob. diff.2.83.74.22.0-2.0-2.02.0-1.91.9-1.9-2.01.9-1.9-1.61.9
Pavlov. Cond. response bias1.62.22.41.5-1.5-1.51.5-1.51.5-1.5-1.61.5-1.5-1.31.5
Time in closed arm before self-admin0.30.40.50.6-0.7-0.70.6-0.60.6-0.6-0.70.7-0.7-0.40.3
Time in closed arm after self-admin0.10.10.30.0-0.10.1-0.20.2-0.20.20.1-0.10.10.6-0.5
Time in open arm before self-admin0.10.10.40.1-0.3-0.30.3-0.30.3-0.3-0.10.1-0.1-0.60.7
Time in open arm after self-admin0.60.70.9-0.90.80.9-0.80.8-0.80.80.8-0.80.80.5-0.8
Bone: periosteal estimation0.30.60.70.7-0.7-0.80.8-0.80.8-0.8-0.80.8-0.8-0.90.6
Bone: periosteal perimeter0.10.20.30.4-0.4-0.50.5-0.50.5-0.5-0.40.4-0.4-0.60.4
Bone: post-yield work0.20.30.40.5-0.5-0.60.5-0.50.5-0.5-0.50.5-0.5-0.60.4
Progressive ratio test 1 active lever presses2.22.73.61.6-1.7-1.81.6-1.61.6-1.6-1.61.6-1.6-1.91.6
Progressive ratio test 1 breakpoint2.53.14.01.7-1.8-1.91.7-1.71.7-1.7-1.71.7-1.7-2.01.7
Progressive ratio test 1 inactive lever presses0.91.32.10.9-0.7-1.41.1-1.11.2-1.2-1.21.2-1.2-1.41.0
Progressive ratio test 2 active lever presses2.73.14.01.8-2.0-1.91.7-1.71.7-1.7-1.71.7-1.7-1.91.4
Progressive ratio test 2 breakpoint2.93.34.21.9-2.0-2.01.8-1.81.8-1.8-1.81.8-1.8-1.91.4
Progressive ratio test 2 inactive lever presses0.71.22.51.1-1.2-1.21.0-1.01.0-1.0-0.81.0-1.0-1.60.8
Incentive Sensitization - Responses2.84.04.52.1-2.1-2.12.0-2.02.0-2.0-2.02.0-2.0-2.01.6
Incentive Sensitization - Breakpoint2.53.33.61.9-1.9-1.91.8-1.81.8-1.8-1.91.8-1.8-1.81.5
Sum of active levers in priming session hrs 5-61.81.72.1-1.21.11.3-1.41.4-1.41.41.3-1.31.31.4-1.4
Progressive ratio0.10.10.40.2-0.6-0.30.3-0.30.3-0.3-0.40.3-0.3-0.60.3
Food seeking constrained by brief footshock2.83.43.91.7-1.6-1.91.8-1.81.8-1.8-1.92.0-2.0-1.81.9
Seeking ratio, punishment vs. effort0.60.91.11.0-0.6-1.00.9-0.90.9-0.9-0.91.0-1.0-0.81.1
Retroperitoneal fat weight0.00.20.30.4-0.4-0.40.5-0.50.5-0.5-0.50.4-0.4-0.40.5
Reaction time number correct6.612.615.13.9-3.9-3.63.6-3.63.6-3.5-3.73.4-3.4-3.43.0
Reaction time mean minus median0.00.00.10.2-0.2-0.20.1-0.10.1-0.10.0-0.10.1-0.3-0.0
Reaction time mean minus median AUC0.10.30.70.7-0.8-0.50.5-0.50.5-0.5-0.40.4-0.4-0.70.3
Reaction time num false alarms0.30.40.7-0.80.60.6-0.70.7-0.70.70.7-0.60.60.4-0.4
Reaction time num false alarms AUC0.71.01.4-1.20.91.0-1.11.1-1.11.11.1-1.01.00.7-0.8
Reaction time trials correct on left6.612.615.13.9-3.9-3.63.6-3.63.6-3.5-3.73.4-3.4-3.43.0
Reaction time trials on left6.812.715.23.9-3.9-3.63.6-3.63.6-3.6-3.73.5-3.5-3.43.1
Reaction time mean1.62.62.7-1.61.61.6-1.61.6-1.61.61.6-1.61.61.4-1.6
Reaction time mean AUC1.42.22.3-1.51.51.5-1.51.5-1.51.51.4-1.51.51.3-1.5
Median of all reaction times2.94.14.4-2.12.02.1-2.12.1-2.12.12.0-2.02.01.8-1.9
Reaction time omissions0.20.40.70.7-0.8-0.60.5-0.50.5-0.5-0.40.5-0.5-0.70.7
Reaction time false alarm rate5.37.39.0-3.02.72.7-2.82.8-2.82.82.8-2.72.72.4-2.3
Reaction time premature initiation rate4.05.56.22.3-2.4-2.42.4-2.42.4-2.4-2.32.4-2.4-2.22.5
Reaction time premature initiations9.116.318.14.2-4.3-4.14.1-4.04.0-4.0-4.04.0-4.0-3.83.9
Std. dev. reaction times0.20.30.5-0.40.40.5-0.60.6-0.60.60.6-0.70.70.4-0.7
Reaction time trials completed6.812.715.23.9-3.9-3.63.6-3.63.6-3.6-3.73.5-3.5-3.43.1
Reaction time trials AUC6.111.613.83.7-3.7-3.43.4-3.43.4-3.4-3.53.3-3.3-3.33.0
Run reversals in cocaine runway, females0.50.51.1-0.60.60.7-0.70.7-0.70.70.6-0.50.51.0-0.9
Run reversals in cocaine runway, males0.10.10.30.5-0.5-0.30.2-0.20.2-0.2-0.30.2-0.20.1-0.1
Latency to leave start box in cocaine runway2.22.53.2-1.61.31.7-1.61.6-1.61.61.4-1.51.51.8-1.7
Latency to leave start box in cocaine runway, F0.20.20.4-0.50.50.6-0.50.5-0.50.50.1-0.30.30.6-0.5
Latency to leave start box in cocaine runway, M2.62.43.2-1.51.21.5-1.51.5-1.51.51.6-1.71.71.8-1.6
Std. dev. time between licks in bursts0.70.91.6-0.80.80.8-0.90.9-0.90.90.9-1.11.11.3-1.1
Total sessions with >9 infusions0.91.11.81.0-1.0-1.10.9-1.01.0-1.0-1.10.9-0.9-1.31.1
Short access day 1 total inactive lever presses1.11.42.40.9-0.9-1.21.2-1.21.2-1.2-1.01.1-1.1-1.51.3
Short access day 10 total inactive lever presses0.10.20.3-0.40.30.6-0.50.5-0.50.50.4-0.50.50.5-0.5
Short access day 1 total infusions0.50.71.90.6-0.6-0.90.7-0.80.8-0.8-0.90.8-0.8-1.40.9
Short access day 10 total infusions1.72.22.71.6-1.6-1.61.4-1.41.4-1.4-1.41.5-1.5-1.61.4
Short access total infusions1.31.72.41.2-1.2-1.51.2-1.31.3-1.3-1.31.3-1.3-1.51.3
Short access day 1 locomotion0.10.20.90.4-0.4-0.20.3-0.30.3-0.3-0.30.2-0.2-0.90.3
Short access day 10 total locomotion0.50.91.4-0.50.61.1-1.01.0-1.01.01.2-1.11.10.6-0.8
Short access total locomotion0.30.40.90.8-0.7-0.50.5-0.50.5-0.5-0.40.4-0.4-1.00.6
One hour access (0.3 mA shock)2.32.74.51.9-1.9-1.61.6-1.61.6-1.6-1.31.5-1.5-2.11.4
Compulsive drug intake1.61.92.7-1.21.31.4-1.41.4-1.41.41.3-1.21.21.6-1.5
One hour access (shock baseline)3.45.18.02.3-2.3-2.32.2-2.22.2-2.2-2.02.1-2.1-2.82.3
Social response proportion0.00.00.1-0.10.10.2-0.20.2-0.20.20.3-0.20.20.2-0.1
Social responses1.41.82.71.6-1.6-1.41.3-1.31.3-1.3-1.41.4-1.4-0.71.0
Social time0.00.00.10.20.00.1-0.10.1-0.10.10.4-0.20.2-0.40.1
Soleus weight0.20.60.8-0.80.80.9-0.80.8-0.80.80.9-0.90.90.3-0.3
Bone: stiffness0.20.40.50.6-0.7-0.60.6-0.60.6-0.6-0.60.6-0.6-0.70.6
Tibialis anterior weight2.68.811.1-3.02.82.8-3.03.0-3.03.02.8-3.03.03.3-3.1
Time to tail flick, vehicle, before self-admin1.81.92.81.5-1.2-1.21.3-1.31.3-1.3-1.31.3-1.3-1.61.7
Time to tail flick, vehicle, after self-admin0.00.10.2-0.1-0.3-0.30.2-0.20.2-0.2-0.40.3-0.3-0.1-0.0
Time to tail flick, test, before self-admin0.20.20.5-0.30.40.4-0.40.4-0.40.40.7-0.50.50.1-0.3
Time to tail flick, test, after self-admin1.51.52.0-1.21.21.2-1.31.3-1.31.31.1-1.01.01.4-1.4
Delta time to tail flick, vehicle, before/after SA0.90.81.5-1.20.80.7-0.90.9-0.90.90.7-0.80.81.1-1.2
Delta time to tail flick, test, before/after SA0.00.00.2-0.00.0-0.1-0.00.0-0.00.0-0.30.2-0.20.4-0.2
Tibia length6.718.521.94.2-4.2-4.24.2-4.34.3-4.3-4.34.2-4.2-4.64.7
Ambulatory time before self-admin0.10.20.40.2-0.3-0.40.4-0.40.4-0.4-0.60.6-0.6-0.30.2
Ambulatory time after self-admin1.01.21.91.0-0.9-1.01.1-1.11.1-1.1-1.41.2-1.2-0.81.1
Bone: tissue strength0.80.80.9-0.90.80.9-0.90.9-0.90.90.9-0.90.90.6-0.8
Total heroin consumption1.51.72.2-1.31.01.3-1.31.3-1.31.31.2-1.41.41.4-1.5
Bone: trabecular number0.00.00.0-0.0-0.0-0.00.0-0.00.0-0.0-0.10.0-0.0-0.0-0.1
Bone: trabecular spacing0.10.20.2-0.50.50.4-0.40.4-0.40.40.5-0.40.40.3-0.2
Bone: trabecular thickness0.60.70.9-0.80.80.9-0.90.9-0.90.90.8-0.90.90.7-1.0
Bone: trabecular tissue density2.73.94.4-1.91.92.1-2.02.0-2.02.02.0-2.02.01.9-1.9
Water consumed over 24 hours0.40.60.8-0.80.90.7-0.80.8-0.80.80.7-0.70.70.7-0.7
Number of responses in last shaping day0.60.61.0-1.00.60.7-0.90.9-0.90.90.6-0.90.90.4-0.9