Hub : Genes

Ppp3r1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Ppp3r1 0.35 0.03 0.0e+00 0.22 0.23 0.26 0.25 5.0e-24 6.0e-25 2.3e-28 2.1e-27
2 PL alternative polyA NM_017309.3 0.03 0.02 8.9e-04 0.01 0.02 0.01 0.01 4.9e-02 6.0e-03 4.3e-02 3.1e-02
3 PL alternative polyA XM_063273012.1 0.03 0.03 3.2e-04 0.03 0.02 0.02 0.02 8.1e-04 2.4e-03 5.9e-03 6.1e-03
4 PL alternative polyA NM_017309.3 0.03 0.02 1.1e-03 0.01 0.01 0 0 3.9e-02 9.1e-03 8.2e-02 8.4e-02
5 PL alternative polyA XM_006251517.5 0.04 0.03 1.8e-04 0.01 0.02 0.01 0.01 2.1e-02 1.6e-03 9.8e-03 1.6e-02
6 Adipose mRNA stability Ppp3r1 0.04 0.03 1.9e-05 0.01 0.04 0.05 0.04 1.2e-02 2.3e-05 1.8e-06 2.6e-05
7 BLA isoform ratio NM_017309.3 0.05 0.04 3.5e-03 0.01 0.02 -0 0 1.2e-01 3.4e-02 5.9e-01 1.6e-01
8 NAcc alternative polyA NM_017309.3 0.02 0.01 2.0e-03 0.02 0.02 0.01 0.01 1.2e-03 1.2e-03 2.6e-02 4.6e-03
9 NAcc alternative polyA NM_017309.3 0.02 0.01 1.3e-03 0.01 0.02 0.01 0.01 4.2e-03 8.3e-04 4.0e-03 2.5e-03
10 NAcc alternative polyA XM_006251517.5 0.02 0.01 1.7e-03 0.01 0.02 0.01 0.01 3.7e-03 1.7e-03 8.9e-03 7.0e-03
11 NAcc alternative polyA XM_063273012.1 0.02 0.01 1.1e-03 0.01 0.02 0.01 0.01 2.5e-03 1.1e-03 6.2e-03 4.3e-03
12 Brain mRNA stability Ppp3r1 0.05 0.04 9.0e-04 0.03 0.03 0.03 0.03 4.0e-04 4.4e-04 7.5e-04 8.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.73.23.9-1.5-1.9-1.9-2.02.0-1.3-1.8-1.9-1.91.81.8-1.6
Area under the delay curve0.91.31.5-1.2-1.2-0.7-1.11.1-1.2-1.2-1.2-1.21.21.2-1.2
BMI with tail1.65.48.1-2.6-2.2-2.8-2.22.3-2.0-2.1-2.4-2.42.42.4-2.1
BMI without tail0.31.62.1-1.3-1.2-1.5-1.11.2-1.0-1.2-1.3-1.31.31.3-1.3
Body weight1.56.68.7-2.9-2.7-2.8-2.72.7-2.9-2.5-2.4-2.32.32.3-2.1
Weight adjusted by age0.20.61.80.00.40.60.3-0.3-0.20.81.01.1-1.1-1.11.3
Bone surface2.55.06.1-2.1-2.3-2.5-2.32.4-1.8-2.2-2.3-2.32.32.3-2.1
Bone volume1.83.64.2-1.8-2.0-2.1-2.02.0-1.5-1.9-2.0-2.01.91.9-1.7
Breakpoint value in progressive ratio session1.01.82.61.61.21.01.2-1.21.61.31.31.3-1.3-1.31.5
Number of licking bursts0.61.83.0-1.7-1.6-1.3-1.61.6-1.7-1.3-1.1-1.11.11.0-0.8
Context. condit. distance diff. score1.82.23.4-1.6-1.7-1.5-1.71.7-1.8-1.5-1.3-1.21.21.2-1.0
Locomotion velocity, session 10.80.92.71.41.00.51.0-0.91.70.90.60.6-0.6-0.60.6
Locomotion distance, session 10.81.03.11.51.10.61.1-1.11.80.90.60.6-0.6-0.50.4
Locomotion velocity, session 20.30.42.21.00.60.10.6-0.51.50.3-0.2-0.20.20.3-0.2
Locomotion distance, session 24.66.512.63.22.92.42.9-2.93.52.42.02.0-2.0-1.91.7
Locomotion velocity, session 30.10.10.20.4-0.1-0.2-0.10.10.5-0.2-0.4-0.40.40.4-0.4
Locomotion distance, session 30.80.91.5-0.6-0.8-1.0-0.80.8-0.5-1.0-1.1-1.11.11.1-1.2
Stereotopy head waving bouts, day 30.20.21.10.60.30.20.3-0.31.0-0.0-0.4-0.50.40.5-0.5
Stereotopy head waving duration, day 30.40.51.41.00.80.80.8-0.81.20.60.40.4-0.4-0.30.4
Locomotion velocity, session 70.10.10.6-0.5-0.5-0.3-0.50.5-0.7-0.4-0.1-0.10.10.0-0.1
Locomotion distance, session 70.91.12.20.70.80.60.7-0.70.41.11.31.3-1.3-1.41.5
Stereotopy head waving bouts, day 70.30.30.90.70.40.70.5-0.60.7-0.2-0.4-0.40.40.4-0.9
Stereotopy head waving duration, day 70.30.30.90.70.50.70.6-0.70.8-0.2-0.3-0.40.40.4-0.9
Locomotion velocity, session 80.00.00.10.20.1-0.10.1-0.10.30.0-0.1-0.10.10.1-0.1
Locomotion distance, session 80.60.92.31.31.00.71.0-1.01.50.90.70.7-0.7-0.70.6
Degree of sensitization distance4.85.18.01.81.92.01.9-1.81.42.32.62.7-2.7-2.72.8
Degree of sensitization stereotypy0.40.41.6-0.1-0.30.1-0.20.1-0.3-0.8-0.8-0.80.80.8-1.3
Conditioned locomotion4.55.37.22.42.01.61.9-1.92.32.52.52.5-2.5-2.52.7
Cocaine response after cond. corrected0.00.00.1-0.1-0.2-0.2-0.20.3-0.10.00.00.0-0.1-0.10.3
Cocaine response after cond. not corrected0.10.10.3-0.5-0.4-0.2-0.40.4-0.6-0.4-0.3-0.30.30.3-0.2
Cocaine response before conditioning0.70.81.5-1.1-0.8-0.4-0.70.7-1.2-1.0-0.8-0.80.90.8-1.1
Saline control response0.10.20.4-0.3-0.3-0.6-0.30.3-0.1-0.3-0.5-0.50.50.5-0.4
Bone: connectivity density3.75.86.6-2.1-2.5-2.6-2.52.5-1.7-2.4-2.6-2.62.52.6-2.3
Bone: cortical apparent density0.10.10.30.00.2-0.10.2-0.10.30.40.30.3-0.3-0.30.6
Bone: cortical area2.23.54.3-1.9-1.7-2.0-1.71.7-1.6-1.9-2.0-2.02.02.0-2.1
Bone: cortical porosity0.60.70.8-0.8-0.9-0.8-0.90.9-0.6-0.8-0.9-0.90.90.9-0.7
Bone: cortical porosity0.60.70.9-0.7-0.8-0.8-0.80.8-0.5-0.8-0.9-0.90.91.0-0.9
Bone: cortical thickness3.15.16.4-2.2-2.0-2.3-2.01.9-1.8-2.3-2.5-2.52.52.5-2.5
Bone: cortical thickness2.93.54.9-2.0-2.1-1.9-2.12.1-2.2-1.9-1.7-1.71.71.6-1.5
Bone: cortical tissue density0.10.20.60.10.30.00.3-0.20.40.60.50.5-0.5-0.50.8
Condit. Reinf. active minus inactive responses0.10.10.20.00.20.40.2-0.2-0.10.30.40.4-0.4-0.40.3
Condit. Reinf. active-inactive response ratio0.10.10.2-0.30.00.1-0.00.1-0.20.30.40.4-0.4-0.40.5
Condit. Reinf. active responses0.00.00.00.00.00.1-0.00.0-0.10.10.20.2-0.2-0.20.1
Condit. Reinf. inactive responses0.00.00.10.2-0.1-0.1-0.10.1-0.0-0.10.00.0-0.0-0.00.0
Incentive salience index mean0.00.00.1-0.3-0.1-0.1-0.10.2-0.30.10.10.1-0.1-0.10.1
Condit. Reinf. lever presses0.00.00.1-0.0-0.2-0.4-0.20.20.0-0.2-0.2-0.20.20.2-0.2
Condit. Reinf. active minus inactive responses0.91.33.5-0.8-0.5-0.5-0.40.4-0.4-1.2-1.5-1.51.51.6-1.9
Condit. Reinf. active-inactive response ratio1.42.24.5-1.3-1.0-0.9-1.00.9-1.1-1.6-1.8-1.81.81.8-2.1
Condit. Reinf. active responses0.71.12.6-0.6-0.4-0.7-0.40.4-0.1-1.0-1.4-1.41.41.4-1.6
Condit. Reinf. inactive responses0.00.00.20.10.0-0.2-0.00.10.40.1-0.0-0.00.00.00.1
Condit. Reinf. lever presses2.33.44.1-1.9-1.6-1.9-1.61.6-1.4-1.8-2.0-2.02.02.0-2.0
Condit. Reinf. lever reinforcers received0.91.22.7-0.8-0.5-0.9-0.50.5-0.2-1.0-1.4-1.51.51.5-1.6
Conditioned reinforcement - actives0.10.30.40.30.60.30.6-0.60.50.60.60.5-0.6-0.50.6
Conditioned reinforcement - inactives0.92.53.3-1.5-1.6-1.8-1.61.5-1.4-1.6-1.6-1.61.61.6-1.5
Conditioned locomotion0.10.10.2-0.20.40.30.4-0.4-0.00.40.40.4-0.4-0.40.4
Patch foraging indifference point 0 sec0.10.20.90.1-0.3-0.1-0.40.50.20.30.30.3-0.4-0.40.9
Patch foraging indifference point AUC0.30.71.0-0.9-0.6-0.7-0.60.5-0.6-0.8-0.9-1.01.01.0-1.0
Delay disc. indifference point, 0s delay2.32.63.7-1.6-1.4-1.1-1.31.3-1.4-1.7-1.8-1.81.81.9-1.9
Delay disc. indifference point, 16s delay0.10.10.4-0.4-0.10.6-0.10.0-0.6-0.10.10.1-0.1-0.1-0.0
Delay disc. indifference point, 2s delay3.23.54.7-1.7-1.7-1.7-1.71.7-1.2-1.9-2.1-2.22.12.2-2.0
Delay disc. indifference point, 24s delay0.71.22.1-0.9-1.2-0.3-1.21.1-1.5-1.4-1.0-0.91.00.9-1.2
Delay disc. indifference point, 4s delay0.70.81.0-0.8-0.8-0.8-0.80.8-0.6-0.8-1.0-1.01.01.0-0.9
Delay disc. indifference point, 8s delay0.71.21.9-1.4-1.1-0.9-1.21.1-1.3-1.1-1.1-1.11.11.0-0.9
Indifference point function ln k0.10.20.80.6-0.0-0.1-0.10.20.40.40.50.5-0.6-0.60.9
Indifference point function log k0.10.20.80.6-0.0-0.1-0.10.20.40.40.50.5-0.6-0.60.9
Patch foraging total patch changes 0 sec0.10.31.20.3-0.10.0-0.20.30.50.50.50.5-0.5-0.51.1
Patch foraging total patch changes 12 sec0.00.00.1-0.4-0.20.1-0.20.2-0.2-0.1-0.1-0.10.10.10.0
Patch foraging total patch changes 18 sec0.00.00.1-0.30.1-0.20.1-0.00.20.0-0.2-0.20.20.3-0.2
Patch foraging total patch changes 24 sec0.00.10.30.20.30.10.3-0.30.50.40.20.2-0.2-0.20.4
Patch foraging total patch changes 6 sec0.10.10.3-0.3-0.4-0.3-0.40.50.1-0.2-0.4-0.40.40.4-0.1
Patch foraging time to switch 0 sec0.51.83.01.21.51.71.5-1.51.01.31.31.3-1.3-1.31.0
Patch foraging water rate 0 sec1.24.75.9-2.0-2.4-2.4-2.42.4-1.9-2.2-2.1-2.12.12.1-1.7
Patch foraging water rate 12 sec1.76.98.0-2.4-2.6-2.6-2.62.5-2.1-2.7-2.8-2.82.82.8-2.6
Patch foraging water rate 18 sec0.41.01.9-0.8-1.1-1.4-1.11.1-0.6-0.9-1.0-1.01.01.0-0.7
Patch foraging water rate 24 sec1.11.62.0-0.8-1.4-1.2-1.41.4-0.6-1.3-1.4-1.41.41.4-1.1
Patch foraging water rate 6 sec2.33.44.1-1.7-1.8-2.0-1.81.8-1.4-1.8-2.0-2.01.92.0-1.8
Seeking ratio, delayed vs. immediate footshock0.20.30.6-0.40.30.60.2-0.2-0.50.50.60.6-0.6-0.70.7
Distance traveled before self-admin1.94.25.7-0.9-2.1-2.4-2.12.1-0.8-2.2-2.3-2.32.32.3-2.1
Distance traveled after self-admin0.40.61.10.6-0.8-1.0-0.80.80.5-0.8-0.9-0.90.90.9-0.6
Extensor digitorum longus weight5.321.028.7-5.4-4.7-4.5-4.74.7-5.0-4.5-4.4-4.34.34.3-3.9
Bone: elastic displacement0.60.81.6-0.7-0.7-0.5-0.60.6-0.7-1.0-1.0-1.01.01.0-1.3
Bone: elastic work1.62.12.6-1.6-1.6-1.6-1.61.6-1.6-1.4-1.4-1.31.31.3-1.2
Bone: endosteal estimation0.00.00.10.10.1-0.10.00.00.20.30.30.3-0.3-0.30.3
Bone: endosteal perimeter0.00.00.1-0.1-0.0-0.1-0.00.0-0.10.10.20.2-0.2-0.20.1
Epididymis fat weight0.20.92.10.50.70.40.7-0.60.51.11.21.2-1.2-1.21.4
Delta time in closed arm before/after self-admin0.10.10.30.5-0.30.1-0.40.3-0.2-0.20.20.2-0.2-0.30.2
Delta time in open arm before/after self-admin0.50.60.8-0.5-0.9-0.6-0.90.9-0.6-0.9-0.8-0.80.80.8-0.6
Diff in mean of infusions in LGA sessions0.91.62.2-0.7-1.4-1.5-1.41.4-0.8-1.4-1.3-1.31.31.2-1.1
Delay discount exponential model param1.31.82.11.31.40.91.3-1.31.21.51.41.4-1.4-1.41.4
Extinction: sum of active levers before priming0.00.00.2-0.50.10.20.1-0.1-0.20.20.20.2-0.2-0.20.2
Active lever presses in extinction session 60.20.20.5-0.6-0.1-0.4-0.10.1-0.3-0.4-0.6-0.60.60.6-0.7
Bone: final force1.52.42.8-1.7-1.5-1.4-1.51.5-1.7-1.7-1.5-1.51.51.5-1.7
Bone: final moment1.62.63.1-1.7-1.6-1.5-1.61.6-1.8-1.7-1.5-1.51.51.5-1.6
Food consumed during 24 hour testing period1.83.64.4-2.0-2.0-2.1-2.02.0-1.8-1.8-1.9-1.91.81.8-1.6
Glucose1.82.84.6-2.1-1.8-1.8-1.81.8-2.2-1.6-1.4-1.31.31.3-1.1
Heart weight0.50.81.8-1.3-0.8-1.0-0.80.8-1.3-0.8-0.7-0.70.70.7-0.8
Delay discount hyperbolic model param1.52.02.41.31.41.01.4-1.41.21.51.51.5-1.5-1.51.5
Intermittent access intake day 1-15 change0.10.40.90.1-0.3-0.6-0.20.20.2-0.6-0.7-0.80.80.8-0.9
Intermittent access intake escalation0.10.40.80.1-0.4-0.8-0.40.40.1-0.7-0.8-0.80.80.8-0.9
Intermittent access intake escalation 20.30.60.9-0.4-0.7-0.9-0.60.6-0.4-0.8-0.9-0.90.90.9-1.0
Intermitt. access day 1 inactive lever presses0.00.10.3-0.3-0.30.2-0.20.2-0.6-0.2-0.00.00.0-0.0-0.1
Intermitt. access day 15 inactive lever presses0.10.51.50.1-0.4-0.2-0.40.3-0.0-0.9-0.9-0.91.01.0-1.2
Intermitt. access escalation Index0.00.00.1-0.2-0.3-0.3-0.30.3-0.3-0.2-0.1-0.10.10.1-0.1
Intermittent access day 1 total infusions0.10.21.0-1.0-0.2-0.2-0.20.2-1.0-0.10.10.1-0.1-0.10.2
Intermittent access day 15 total infusions0.00.00.10.1-0.0-0.30.0-0.00.0-0.2-0.2-0.20.20.2-0.3
Intermittent access terminal intake (last 3 days)0.20.40.5-0.5-0.5-0.6-0.50.5-0.6-0.7-0.7-0.70.70.7-0.7
Intermittent access total infusions0.10.20.4-0.5-0.4-0.4-0.40.3-0.6-0.5-0.4-0.30.40.3-0.4
Intermittent access day 1 locomotion0.10.10.1-0.20.30.30.3-0.3-0.10.30.30.3-0.3-0.30.4
Intermittent access day 15 total locomotion0.10.40.60.60.70.50.6-0.60.70.70.60.6-0.6-0.60.8
Intermittent access total locomotion0.00.00.0-0.10.10.20.1-0.1-0.10.10.10.1-0.1-0.10.1
Intermittent access standard deviation0.10.41.5-0.20.61.20.7-0.7-0.30.40.60.6-0.6-0.60.3
Left kidney weight0.42.94.9-2.1-1.9-1.7-1.91.9-2.2-1.7-1.5-1.41.41.4-1.3
Right kidney weight0.21.62.6-1.5-1.4-1.3-1.51.4-1.6-1.3-1.1-1.11.11.0-1.0
Cocaine induced anxiety1.23.36.41.22.42.02.5-2.51.51.81.61.6-1.5-1.50.9
Post-drug Anxiety0.30.30.90.20.80.80.9-1.00.30.30.20.2-0.1-0.1-0.3
Baseline Anxiety2.84.75.7-1.4-2.4-2.0-2.42.4-1.5-2.4-2.3-2.32.32.3-2.0
Tail length0.00.00.2-0.2-0.2-0.1-0.20.2-0.4-0.2-0.1-0.10.10.1-0.2
Length with tail0.10.41.3-0.7-0.8-0.5-0.90.9-1.1-0.5-0.2-0.10.10.10.1
Length without tail0.52.95.8-2.2-2.0-1.9-2.12.1-2.4-1.5-1.2-1.11.11.1-0.7
Times rat made contact with spout1.41.62.6-1.3-1.4-1.6-1.41.5-1.1-1.1-1.1-1.11.11.1-0.9
Lifetime Intake0.20.20.3-0.4-0.5-0.5-0.50.5-0.5-0.5-0.4-0.40.40.4-0.4
Liver weight, left2.03.54.5-2.1-1.7-1.9-1.71.7-1.6-1.8-2.0-2.02.02.0-1.8
Liver weight, right0.10.10.3-0.5-0.5-0.4-0.50.5-0.6-0.2-0.1-0.10.00.00.1
Locomotor activity0.10.10.40.2-0.1-0.0-0.20.20.10.20.30.3-0.3-0.30.7
Locomotor testing distance0.51.22.41.10.90.90.8-0.81.01.21.21.2-1.2-1.21.5
Locomotor testing rearing0.10.20.5-0.4-0.6-0.6-0.70.7-0.6-0.2-0.1-0.10.00.00.5
Locomotion in novel chamber0.20.20.5-0.5-0.30.0-0.30.2-0.7-0.6-0.5-0.40.50.5-0.7
Locomotion in novel chamber post-restriction0.10.21.4-1.20.0-0.30.0-0.0-0.80.10.00.0-0.00.0-0.1
Fecal boli incidents, locomotor time 10.82.12.8-1.5-1.6-1.5-1.61.5-1.7-1.5-1.3-1.31.31.3-1.2
Change in fecal boli incidents, locomotor task1.41.53.01.71.01.41.0-1.01.41.11.11.2-1.1-1.21.1
Time >=10cm from walls, locomotor time 10.70.91.80.31.30.71.3-1.30.91.10.70.7-0.7-0.60.7
Bouts of movement, locomotor time 10.10.10.40.1-0.3-0.7-0.40.40.00.00.00.0-0.0-0.00.3
Total resting periods, locomotor time 10.00.00.20.3-0.2-0.5-0.20.30.20.00.00.1-0.1-0.10.2
Rest time, locomotor task time 10.00.00.20.5-0.00.1-0.00.00.4-0.0-0.0-0.00.00.00.0
Distance moved, locomotor task time 10.20.51.20.61.00.41.0-1.01.10.80.40.3-0.4-0.30.4
Vertical activity count, locomotor time 10.00.10.4-0.60.1-0.30.1-0.1-0.5-0.1-0.1-0.10.10.1-0.2
Time >=10cm from walls, locomotor time 21.13.24.31.62.02.12.1-2.11.61.81.61.6-1.6-1.61.4
Bouts of movement, locomotor time 21.54.98.72.62.11.42.1-1.92.92.52.12.0-2.1-2.02.4
Total resting periods, locomotor time 21.24.98.32.62.11.52.1-1.92.92.52.12.1-2.1-2.02.4
Rest time, locomotor task time 20.71.22.91.71.01.11.0-1.01.50.90.90.9-0.9-0.90.9
Distance moved, locomotor task time 20.10.10.2-0.10.50.10.5-0.50.10.40.20.2-0.2-0.20.1
Vertical activity count, locomotor time 20.10.30.7-0.20.80.70.8-0.8-0.20.50.50.5-0.4-0.40.1
Light reinforcement 10.31.52.0-1.4-1.4-1.3-1.41.4-1.4-1.2-1.0-1.01.01.0-0.8
Light reinforcement 20.10.20.4-0.6-0.4-0.6-0.50.6-0.4-0.0-0.00.0-0.0-0.00.4
Bone: marrow area0.00.10.20.20.10.00.1-0.10.30.30.30.3-0.3-0.30.4
Bone: maximum diameter0.30.60.8-0.8-0.7-0.8-0.70.7-0.7-0.8-0.8-0.80.80.8-0.9
Bone: maximum force0.40.71.1-1.0-0.9-1.0-0.90.9-0.9-0.8-0.8-0.70.70.7-0.8
Bone: maximum moment0.50.91.3-1.1-1.0-1.1-1.01.0-0.9-0.8-0.8-0.80.80.8-0.8
Mean time between licks in bursts0.00.20.80.80.50.30.5-0.50.90.40.20.2-0.2-0.20.3
Mean num. licks in bursts0.30.82.21.21.00.61.0-1.01.50.80.60.6-0.6-0.50.5
Cd content in liver0.40.41.2-0.10.20.10.2-0.1-0.10.70.80.8-0.9-0.91.1
Co content in liver0.10.10.3-0.5-0.0-0.20.0-0.0-0.2-0.3-0.5-0.50.50.5-0.5
Cu content in liver1.51.84.01.41.41.01.4-1.32.01.51.11.1-1.1-1.01.3
Fe content in liver3.13.86.22.22.01.51.9-1.92.52.11.81.8-1.8-1.81.9
K content in liver0.20.20.4-0.2-0.4-0.5-0.40.40.1-0.4-0.6-0.60.60.6-0.4
Mg content in liver0.20.20.40.50.40.40.4-0.30.50.50.50.5-0.5-0.50.6
Mn content in liver0.00.00.10.10.1-0.00.1-0.10.30.1-0.1-0.10.10.1-0.0
Na content in liver0.20.20.90.60.50.30.5-0.50.90.30.10.1-0.1-0.00.1
Rb content in liver0.80.91.7-0.5-0.7-0.8-0.70.7-0.1-0.9-1.2-1.31.21.3-1.1
Se content in liver0.00.00.10.10.1-0.10.1-0.10.2-0.1-0.1-0.10.10.2-0.3
Sr content in liver0.50.41.0-0.9-0.8-1.0-0.91.0-0.9-0.2-0.00.0-0.0-0.00.4
Zn content in liver0.10.10.3-0.3-0.2-0.4-0.30.4-0.20.20.20.2-0.2-0.20.5
Bone: minimum diameter0.81.52.5-1.2-1.0-1.6-1.01.0-0.7-1.1-1.4-1.41.41.4-1.4
Time in familiar zone, hab. session 10.40.40.6-0.6-0.6-0.7-0.60.6-0.2-0.5-0.7-0.70.70.8-0.6
Time in novel zone, hab. session 10.00.00.00.10.00.00.0-0.00.00.10.10.1-0.1-0.10.1
Total zone transitions, hab. session 11.21.62.21.51.21.41.2-1.21.31.21.31.3-1.3-1.31.2
Total locomotion distance, hab. session 13.24.55.82.21.91.91.8-1.82.02.22.32.3-2.3-2.32.4
Locomotion velocity, hab. session 12.83.94.92.01.71.91.7-1.71.72.02.22.2-2.2-2.22.2
Time in familiar zone, hab. session 20.50.61.20.81.01.11.0-1.11.00.60.40.4-0.4-0.30.2
Time in novel zone, hab. session 21.01.12.0-1.2-1.3-1.4-1.31.4-1.4-1.0-0.7-0.70.70.7-0.5
Total zone transitions, hab. session 20.20.21.00.90.40.40.4-0.41.0-0.0-0.2-0.20.20.2-0.4
Total locomotion distance, hab. session 21.92.44.22.01.51.21.5-1.52.11.51.41.4-1.4-1.41.4
Locomotion velocity, hab. session 22.33.04.72.11.71.51.7-1.72.21.71.61.6-1.6-1.61.5
Novel to familiar place preference ratio1.82.45.5-1.9-1.9-1.7-2.02.0-2.3-1.4-0.9-0.90.90.8-0.6
Novelty place preference3.03.97.4-2.4-2.3-2.1-2.32.3-2.7-1.9-1.5-1.41.51.4-1.2
Time in novel zone, NPP test4.55.59.8-2.8-2.7-2.4-2.72.7-3.1-2.3-1.9-1.81.81.8-1.6
Total zone transitions, NPP test0.30.51.21.10.90.80.9-1.01.00.40.30.3-0.3-0.3-0.2
Total locomotion distance, NPP test2.02.83.81.91.81.51.8-1.81.71.61.71.7-1.7-1.71.4
Locomotion velocity, NPP test4.05.77.72.82.52.22.5-2.52.62.32.32.3-2.3-2.32.0
Intraocular pressure0.91.54.1-1.7-1.0-0.9-1.00.9-2.0-1.3-0.9-0.91.00.9-1.4
Delta distance traveled before/after self-admin1.61.72.41.51.11.11.1-1.11.21.31.41.4-1.4-1.41.6
Delta ambulatory time before/after self-admin1.01.82.71.51.11.01.1-1.01.31.41.41.4-1.5-1.51.6
Parametrial fat weight0.00.10.40.6-0.10.3-0.10.00.1-0.00.20.2-0.2-0.30.3
Pavlov. Cond. lever latency1.01.32.81.01.21.71.2-1.20.71.01.21.2-1.1-1.21.0
Pavlov. Cond. magazine entry latency0.10.10.3-0.1-0.4-0.6-0.40.5-0.1-0.3-0.3-0.30.30.3-0.2
Pavlov. Cond. change in total contacts2.12.23.9-1.4-1.6-2.0-1.61.7-1.2-1.4-1.5-1.51.41.4-1.2
Pavlov. Cond. index score0.40.61.4-0.5-0.8-1.2-0.80.8-0.3-0.6-0.8-0.80.70.8-0.6
Pavlov. Cond. latency score0.91.12.2-0.8-1.1-1.5-1.11.1-0.5-1.0-1.1-1.11.11.1-1.0
Pavlov. Cond. lever contacts0.70.82.0-0.6-0.9-1.4-0.90.9-0.3-0.8-1.0-1.01.01.0-0.8
Pavlov. Cond. magazine entry number0.10.10.60.00.40.80.5-0.5-0.20.10.30.3-0.2-0.3-0.0
Pavlov. Cond. intertrial magazine entries0.10.10.40.10.30.60.3-0.4-0.3-0.00.20.3-0.2-0.3-0.2
Pavlov. Cond. lever-magazine prob. diff.0.81.02.2-0.7-1.1-1.5-1.11.1-0.5-0.8-1.0-1.00.91.0-0.7
Pavlov. Cond. response bias0.20.20.9-0.2-0.6-0.9-0.60.7-0.1-0.2-0.3-0.30.20.30.0
Pavlov. Cond. lever latency0.30.50.80.70.50.80.5-0.50.60.70.70.7-0.8-0.80.9
Pavlov. Cond. magazine entry latency0.50.71.9-1.1-0.8-0.7-0.70.7-1.4-0.9-0.7-0.60.70.6-0.9
Pavlov. Cond. change in total contacts0.10.10.4-0.3-0.1-0.4-0.00.00.0-0.3-0.5-0.50.50.5-0.7
Pavlov. Cond. index score0.30.40.9-0.7-0.4-0.6-0.40.3-0.6-0.7-0.7-0.70.80.8-1.0
Pavlov. Cond. latency score0.40.61.3-0.9-0.5-0.7-0.50.4-0.8-0.8-0.8-0.80.90.9-1.1
Pavlov. Cond. lever contacts0.30.40.8-0.6-0.4-0.7-0.40.4-0.5-0.7-0.7-0.70.70.7-0.9
Pavlov. Cond. magazine entry number0.70.91.61.10.70.70.6-0.61.21.00.90.9-0.9-0.91.3
Pavlov. Cond. intertrial magazine entries0.41.02.01.41.01.11.0-1.01.40.90.80.8-0.8-0.80.7
Pavlov. Cond. lever-magazine prob. diff.0.50.71.3-0.9-0.6-0.8-0.50.5-0.7-0.9-0.9-0.91.01.0-1.1
Pavlov. Cond. response bias0.30.40.9-0.7-0.4-0.6-0.40.4-0.6-0.7-0.7-0.70.70.7-0.9
Time in closed arm before self-admin0.20.41.2-1.1-0.3-0.2-0.20.2-0.8-0.5-0.6-0.60.60.6-0.7
Time in closed arm after self-admin0.30.30.30.50.60.50.6-0.60.50.60.60.6-0.6-0.60.5
Time in open arm before self-admin0.20.30.50.00.40.30.4-0.4-0.20.50.70.7-0.7-0.70.6
Time in open arm after self-admin0.30.40.9-0.7-0.6-0.5-0.60.6-0.9-0.6-0.5-0.50.50.5-0.5
Bone: periosteal estimation0.10.30.5-0.5-0.4-0.7-0.40.4-0.2-0.5-0.6-0.60.60.6-0.7
Bone: periosteal perimeter0.10.20.5-0.3-0.2-0.4-0.20.2-0.3-0.4-0.4-0.40.40.4-0.7
Bone: post-yield work1.32.33.31.11.41.11.3-1.31.01.71.81.8-1.8-1.81.8
Progressive ratio test 1 active lever presses0.10.10.2-0.40.40.30.4-0.4-0.10.40.30.3-0.3-0.30.3
Progressive ratio test 1 breakpoint0.00.00.3-0.50.20.10.3-0.3-0.20.20.10.1-0.1-0.10.1
Progressive ratio test 1 inactive lever presses0.51.22.1-0.9-1.0-0.7-0.90.9-0.9-1.3-1.3-1.31.31.3-1.4
Progressive ratio test 2 active lever presses1.41.92.5-1.5-1.3-1.6-1.31.2-1.3-1.4-1.4-1.41.41.4-1.4
Progressive ratio test 2 breakpoint1.52.02.5-1.5-1.3-1.6-1.31.2-1.4-1.5-1.4-1.41.41.4-1.4
Progressive ratio test 2 inactive lever presses0.61.82.4-1.5-1.2-1.3-1.21.1-1.4-1.4-1.4-1.41.41.4-1.4
Incentive Sensitization - Responses3.08.29.5-2.9-2.8-3.1-2.82.7-2.8-3.0-2.8-2.82.92.8-2.8
Incentive Sensitization - Breakpoint3.27.28.3-2.7-2.7-2.9-2.62.5-2.8-2.8-2.6-2.62.72.6-2.7
Sum of active levers in priming session hrs 5-61.11.02.21.11.00.61.0-0.91.51.20.90.9-0.9-0.91.2
Progressive ratio0.51.52.6-0.01.01.30.9-0.9-0.31.21.51.5-1.5-1.61.6
Food seeking constrained by brief footshock0.40.40.6-0.3-0.8-0.8-0.80.8-0.2-0.7-0.7-0.70.70.7-0.5
Seeking ratio, punishment vs. effort0.51.11.9-0.1-0.9-1.3-0.80.90.3-1.0-1.3-1.31.31.4-1.3
Retroperitoneal fat weight0.20.72.5-1.1-0.9-0.6-0.90.8-1.6-0.9-0.5-0.50.50.5-0.6
Reaction time number correct1.34.45.6-1.8-2.2-2.4-2.22.2-1.4-2.1-2.3-2.32.22.3-2.0
Reaction time mean minus median0.10.60.90.40.70.70.7-0.70.20.80.90.9-0.9-0.90.9
Reaction time mean minus median AUC0.42.83.71.31.61.61.5-1.51.01.81.91.9-1.9-1.91.9
Reaction time num false alarms2.33.95.0-2.2-2.0-1.6-2.02.0-2.2-2.1-1.9-1.91.91.9-1.7
Reaction time num false alarms AUC1.22.73.9-1.9-1.7-1.3-1.71.7-2.0-1.7-1.6-1.61.61.6-1.4
Reaction time trials correct on left1.34.45.6-1.8-2.2-2.4-2.22.2-1.4-2.1-2.3-2.32.22.3-2.0
Reaction time trials on left1.13.84.9-1.6-2.0-2.2-2.02.0-1.2-1.9-2.1-2.12.12.1-1.9
Reaction time mean1.32.83.71.71.81.91.9-1.91.41.61.71.7-1.6-1.61.3
Reaction time mean AUC1.94.55.42.12.32.32.3-2.31.92.12.12.1-2.1-2.11.7
Median of all reaction times2.03.24.51.92.02.12.1-2.11.61.61.61.6-1.6-1.61.2
Reaction time omissions2.54.04.71.82.22.02.2-2.21.62.12.12.1-2.0-2.01.9
Reaction time false alarm rate0.20.31.3-0.9-0.50.1-0.50.4-1.1-0.6-0.3-0.30.30.3-0.3
Reaction time premature initiation rate0.10.10.30.50.30.60.3-0.30.10.30.40.5-0.4-0.50.3
Reaction time premature initiations0.10.20.3-0.1-0.5-0.3-0.50.5-0.2-0.5-0.4-0.40.40.4-0.4
Std. dev. reaction times0.61.92.31.01.41.41.4-1.30.81.41.51.5-1.5-1.51.3
Reaction time trials completed1.13.84.9-1.6-2.0-2.2-2.02.0-1.2-1.9-2.1-2.12.12.1-1.9
Reaction time trials AUC1.13.84.7-1.6-2.0-2.2-2.02.0-1.2-1.9-2.1-2.12.12.1-1.9
Run reversals in cocaine runway, females0.20.20.4-0.70.60.30.6-0.6-0.30.50.40.3-0.3-0.30.2
Run reversals in cocaine runway, males0.40.50.70.20.70.90.7-0.80.00.60.80.8-0.8-0.80.6
Latency to leave start box in cocaine runway1.11.51.9-1.2-1.3-1.1-1.21.2-1.4-1.3-1.2-1.11.21.1-1.3
Latency to leave start box in cocaine runway, F0.70.91.3-1.0-0.9-1.1-0.90.9-0.8-0.9-1.0-1.01.01.0-0.8
Latency to leave start box in cocaine runway, M1.11.01.9-0.8-1.0-0.6-1.00.9-1.4-1.2-0.9-0.80.90.8-1.4
Std. dev. time between licks in bursts0.61.13.40.90.50.10.4-0.31.11.31.21.2-1.3-1.21.8
Total sessions with >9 infusions0.10.20.30.10.60.30.6-0.60.30.50.40.4-0.4-0.40.4
Short access day 1 total inactive lever presses0.00.10.3-0.2-0.4-0.5-0.40.5-0.3-0.2-0.2-0.20.20.2-0.1
Short access day 10 total inactive lever presses0.00.10.30.50.30.50.3-0.30.50.30.30.3-0.3-0.30.2
Short access day 1 total infusions0.20.40.50.40.70.50.7-0.70.40.70.70.7-0.7-0.70.7
Short access day 10 total infusions0.30.60.70.40.80.80.8-0.80.30.70.80.9-0.8-0.90.8
Short access total infusions0.00.00.00.10.10.00.1-0.10.10.00.10.1-0.1-0.10.1
Short access day 1 locomotion0.50.81.20.70.91.10.9-0.90.71.00.90.9-0.9-0.91.0
Short access day 10 total locomotion0.21.01.10.71.11.01.1-1.00.81.11.01.0-1.0-1.00.9
Short access total locomotion0.10.10.1-0.40.30.40.3-0.3-0.30.30.30.3-0.3-0.30.3
One hour access (0.3 mA shock)0.30.40.7-0.5-0.4-0.6-0.30.3-0.2-0.7-0.8-0.80.80.9-0.9
Compulsive drug intake1.92.84.3-0.7-1.6-1.4-1.61.5-0.5-1.8-2.0-2.12.02.1-2.0
One hour access (shock baseline)0.00.10.2-0.00.30.10.3-0.4-0.10.30.40.4-0.4-0.40.3
Social response proportion0.50.71.7-0.9-1.1-0.5-1.11.1-1.3-0.9-0.5-0.50.50.5-0.5
Social responses0.00.00.1-0.1-0.20.2-0.20.2-0.20.00.10.1-0.1-0.10.3
Social time0.30.51.1-0.9-0.9-0.9-1.01.1-0.8-0.4-0.4-0.40.30.30.1
Soleus weight2.98.611.8-3.4-3.1-3.1-3.23.2-3.4-2.8-2.6-2.62.62.6-2.3
Bone: stiffness0.00.10.2-0.0-0.2-0.5-0.20.20.2-0.1-0.3-0.30.30.3-0.3
Tibialis anterior weight3.211.015.7-4.0-3.6-3.5-3.63.7-3.8-3.1-2.9-2.92.92.9-2.5
Time to tail flick, vehicle, before self-admin0.10.10.4-0.6-0.30.1-0.30.3-0.6-0.1-0.0-0.00.00.00.1
Time to tail flick, vehicle, after self-admin0.51.02.1-0.9-0.8-0.2-0.80.7-1.1-1.2-1.0-1.01.01.0-1.5
Time to tail flick, test, before self-admin0.50.60.9-0.5-0.7-0.7-0.70.6-0.7-0.9-0.8-0.80.80.8-1.0
Time to tail flick, test, after self-admin0.10.10.4-0.6-0.40.2-0.40.5-0.6-0.00.20.2-0.2-0.20.5
Delta time to tail flick, vehicle, before/after SA2.93.14.5-1.8-1.6-1.6-1.51.4-1.8-1.9-1.8-1.81.81.8-2.1
Delta time to tail flick, test, before/after SA0.10.10.5-0.4-0.30.2-0.30.4-0.30.20.30.3-0.3-0.30.7
Tibia length0.10.40.6-0.4-0.5-0.6-0.50.4-0.2-0.6-0.7-0.80.70.8-0.8
Ambulatory time before self-admin0.82.33.1-0.6-1.5-1.7-1.51.4-0.5-1.6-1.8-1.81.71.8-1.6
Ambulatory time after self-admin0.20.41.11.1-0.4-0.7-0.40.40.9-0.5-0.5-0.50.50.5-0.4
Bone: tissue strength0.60.61.1-0.8-0.7-1.0-0.70.7-0.5-0.7-0.8-0.90.80.9-0.8
Total heroin consumption2.32.73.81.01.61.51.6-1.51.21.81.81.8-1.8-1.81.9
Bone: trabecular number1.83.34.1-1.5-1.8-1.9-1.91.9-1.0-1.8-2.0-2.02.02.0-1.7
Bone: trabecular spacing0.40.61.50.30.71.20.8-0.9-0.40.50.91.0-0.9-1.00.5
Bone: trabecular thickness0.40.51.0-0.4-0.7-1.0-0.70.8-0.1-0.6-0.8-0.80.80.8-0.5
Bone: trabecular tissue density0.71.12.31.11.11.51.2-1.20.70.81.01.1-1.0-1.10.6
Water consumed over 24 hours0.50.91.8-1.0-1.2-1.4-1.31.4-0.8-0.8-0.8-0.70.70.7-0.3
Number of responses in last shaping day1.51.93.41.91.51.51.5-1.51.71.21.21.2-1.2-1.20.9