Hub : Genes

Ppp1r14a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	mRNA stability	Ppp1r14a	0.02	0.02	7.3e-04	0.01	0.02	0.02	0.02	9.0e-03	2.5e-03	4.2e-03	5.5e-03
2	Brain	mRNA stability	Ppp1r14a	0.3	0	1.5e-10	0.11	0.1	0.1	0.1	4.7e-10	1.6e-09	4.0e-09	8.4e-10
3	Liver	gene expression	Ppp1r14a	0.19	0.1	0.0e+00	0.11	0.12	0.13	0.13	1.5e-12	2.5e-13	6.8e-14	8.5e-14
4	NAcc	isoform ratio	NM_130403.2	0.1	0.07	9.3e-03	-0	0.01	0	-0	7.3e-01	2.5e-02	2.8e-01	6.9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.1	0.1	-0.3	0.2	0.2	-0.2
Area under the delay curve	1.5	1.5	5.7	0.5	-0.4	-0.1	-2.4
BMI with tail	0.3	1.0	2.5	-0.9	0.7	0.6	1.6
BMI without tail	0.1	0.3	0.5	0.6	-0.7	-0.6	-0.0
Body weight	2.1	8.9	12.6	3.4	-3.5	-3.3	-0.3
Weight adjusted by age	0.2	0.2	0.3	-0.5	0.4	0.4	0.5
Bone surface	0.2	0.4	0.6	0.7	-0.7	-0.7	-0.5
Bone volume	0.2	0.4	0.5	0.7	-0.7	-0.7	-0.3
Breakpoint value in progressive ratio session	2.7	2.9	6.0	1.8	-1.0	-1.2	-2.5
Number of licking bursts	2.3	2.7	3.2	-1.8	1.8	1.6	1.3
Context. condit. distance diff. score	0.1	0.1	0.2	-0.2	0.3	0.5	-0.3
Locomotion velocity, session 1	1.8	2.0	2.9	-1.5	1.7	1.6	-0.5
Locomotion distance, session 1	0.7	0.8	1.3	1.0	-1.0	-1.2	-0.1
Locomotion velocity, session 2	0.3	0.3	0.5	-0.7	0.5	0.7	0.1
Locomotion distance, session 2	0.9	1.2	2.6	-1.1	0.8	0.7	1.6
Locomotion velocity, session 3	0.3	0.4	0.6	-0.6	0.6	0.5	0.8
Locomotion distance, session 3	4.4	4.8	6.6	2.5	-2.6	-2.6	0.3
Stereotopy head waving bouts, day 3	1.0	1.2	1.8	-1.0	1.0	1.0	1.4
Stereotopy head waving duration, day 3	2.3	2.8	3.9	-1.9	1.9	2.0	0.6
Locomotion velocity, session 7	0.0	0.0	0.2	0.1	-0.1	0.0	-0.4
Locomotion distance, session 7	0.1	0.1	0.1	0.3	-0.3	-0.3	0.1
Stereotopy head waving bouts, day 7	0.3	0.3	0.9	-0.4	0.2	0.2	1.0
Stereotopy head waving duration, day 7	1.0	1.3	1.5	-1.2	1.1	1.0	1.1
Locomotion velocity, session 8	3.3	3.9	4.8	-2.2	2.1	2.1	1.4
Locomotion distance, session 8	0.4	0.5	0.6	-0.8	0.7	0.7	0.6
Degree of sensitization distance	2.7	2.7	3.8	-1.7	1.8	2.0	-0.8
Degree of sensitization stereotypy	0.4	0.4	1.5	-0.3	0.1	-0.1	1.2
Conditioned locomotion	0.8	1.0	3.3	0.3	-0.5	-0.6	1.8
Cocaine response after cond. corrected	0.3	0.4	0.4	0.5	-0.6	-0.6	0.6
Cocaine response after cond. not corrected	0.7	0.8	1.8	0.6	-0.8	-0.8	1.3
Cocaine response before conditioning	1.2	1.5	1.8	1.1	-1.2	-1.2	1.3
Saline control response	0.3	0.4	0.5	0.7	-0.7	-0.7	0.2
Bone: connectivity density	0.4	0.6	0.7	-0.8	0.7	0.9	-0.6
Bone: cortical apparent density	2.0	2.6	3.3	-1.8	1.8	1.7	1.0
Bone: cortical area	1.6	2.4	3.5	1.8	-1.7	-1.9	0.1
Bone: cortical porosity	1.6	1.8	3.9	-1.2	0.9	0.9	2.0
Bone: cortical porosity	1.9	2.1	4.7	-1.3	1.0	1.0	2.2
Bone: cortical thickness	0.6	1.1	1.5	1.1	-1.1	-1.2	0.4
Bone: cortical thickness	0.7	0.8	2.7	-0.6	0.4	0.4	1.6
Bone: cortical tissue density	2.3	3.0	3.9	-2.0	1.9	1.9	1.0
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	-0.6	0.7	0.5	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.4	0.6	0.5	0.0
Condit. Reinf. active responses	1.2	1.5	1.8	-1.3	1.3	0.9	1.3
Condit. Reinf. inactive responses	0.9	1.1	2.1	-1.1	0.9	0.6	1.4
Incentive salience index mean	0.1	0.1	0.4	-0.2	0.2	0.0	0.6
Condit. Reinf. lever presses	0.1	0.2	0.3	0.3	-0.4	-0.5	0.4
Condit. Reinf. active minus inactive responses	3.1	3.8	5.3	2.3	-2.2	-2.3	-0.3
Condit. Reinf. active-inactive response ratio	2.1	2.3	2.8	1.4	-1.5	-1.7	1.4
Condit. Reinf. active responses	3.7	5.2	7.2	2.7	-2.5	-2.6	-0.8
Condit. Reinf. inactive responses	2.1	2.5	3.4	1.6	-1.5	-1.3	-1.8
Condit. Reinf. lever presses	6.6	9.0	11.8	3.4	-3.1	-3.1	-2.3
Condit. Reinf. lever reinforcers received	4.3	6.1	8.4	2.9	-2.8	-2.8	-0.6
Conditioned reinforcement - actives	0.4	0.4	0.6	0.3	-0.8	-0.6	0.7
Conditioned reinforcement - inactives	1.6	1.8	2.6	1.5	-1.6	-1.5	-0.0
Conditioned locomotion	1.3	1.5	2.1	-1.5	1.0	1.2	1.3
Patch foraging indifference point 0 sec	0.2	0.3	0.4	0.5	-0.7	-0.7	0.3
Patch foraging indifference point AUC	0.4	0.4	0.6	-0.7	0.5	0.5	0.8
Delay disc. indifference point, 0s delay	1.0	1.1	1.9	0.9	-1.0	-0.8	-1.4
Delay disc. indifference point, 16s delay	2.5	2.6	4.9	1.4	-1.4	-1.1	-2.2
Delay disc. indifference point, 2s delay	2.1	2.4	9.2	0.5	-0.2	0.1	-3.0
Delay disc. indifference point, 24s delay	1.8	1.8	2.1	1.4	-1.3	-1.1	-1.5
Delay disc. indifference point, 4s delay	0.2	0.3	0.7	0.4	-0.4	-0.3	-0.8
Delay disc. indifference point, 8s delay	1.4	1.4	3.8	-0.5	0.8	1.0	-2.0
Indifference point function ln k	0.4	0.5	0.7	0.8	-0.7	-0.7	-0.7
Indifference point function log k	0.4	0.5	0.7	0.8	-0.7	-0.7	-0.7
Patch foraging total patch changes 0 sec	0.3	0.4	0.6	0.7	-0.8	-0.8	0.0
Patch foraging total patch changes 12 sec	0.2	0.3	0.5	0.5	-0.7	-0.6	0.3
Patch foraging total patch changes 18 sec	0.2	0.2	0.5	-0.4	0.2	0.3	0.7
Patch foraging total patch changes 24 sec	0.7	0.8	1.0	0.9	-1.0	-1.0	-0.5
Patch foraging total patch changes 6 sec	0.1	0.2	0.3	0.2	-0.4	-0.4	0.5
Patch foraging time to switch 0 sec	0.9	1.4	2.1	-1.2	1.2	1.5	-0.7
Patch foraging water rate 0 sec	0.5	0.8	0.9	-0.9	0.9	0.7	1.0
Patch foraging water rate 12 sec	0.6	0.9	1.5	1.1	-1.0	-1.2	-0.3
Patch foraging water rate 18 sec	0.7	1.0	1.3	-0.7	1.1	0.9	-1.2
Patch foraging water rate 24 sec	0.2	0.2	0.4	0.6	-0.4	-0.6	0.3
Patch foraging water rate 6 sec	0.2	0.4	1.0	0.5	-0.2	-0.4	-1.0
Seeking ratio, delayed vs. immediate footshock	1.0	1.2	1.9	1.4	-1.0	-1.1	-0.7
Distance traveled before self-admin	1.3	1.3	2.0	1.4	-1.1	-1.4	0.5
Distance traveled after self-admin	4.5	5.1	6.6	2.6	-2.5	-2.6	-0.8
Extensor digitorum longus weight	0.2	0.6	0.9	-0.9	0.9	0.9	0.1
Bone: elastic displacement	0.0	0.0	0.1	-0.2	0.2	0.2	-0.3
Bone: elastic work	1.7	2.1	3.0	1.7	-1.6	-1.7	-0.1
Bone: endosteal estimation	1.1	2.5	3.1	1.8	-1.7	-1.7	-1.0
Bone: endosteal perimeter	1.3	2.7	3.1	1.7	-1.7	-1.6	-1.5
Epididymis fat weight	0.0	0.0	0.1	-0.2	0.0	0.1	0.3
Delta time in closed arm before/after self-admin	0.9	0.9	1.3	0.8	-1.2	-0.8	-0.9
Delta time in open arm before/after self-admin	0.7	0.7	2.3	-0.4	0.6	0.2	1.5
Diff in mean of infusions in LGA sessions	0.2	0.2	0.6	0.4	-0.1	-0.2	-0.8
Delay discount exponential model param	1.4	1.4	5.2	-0.6	0.4	0.2	2.3
Extinction: sum of active levers before priming	1.3	1.3	1.6	1.3	-1.2	-1.2	-0.8
Active lever presses in extinction session 6	1.5	1.5	3.7	0.9	-0.9	-0.7	-1.9
Bone: final force	1.3	2.1	2.9	1.6	-1.7	-1.7	0.1
Bone: final moment	1.9	3.1	4.3	2.0	-2.0	-2.1	0.1
Food consumed during 24 hour testing period	0.4	0.5	0.6	0.8	-0.6	-0.7	-0.8
Glucose	0.2	0.3	0.4	-0.7	0.6	0.5	0.1
Heart weight	0.5	0.7	0.9	0.9	-0.9	-0.9	0.5
Delay discount hyperbolic model param	1.3	1.4	5.4	-0.5	0.3	0.1	2.3
Intermittent access intake day 1-15 change	1.6	1.5	2.2	1.3	-1.5	-1.3	-0.8
Intermittent access intake escalation	1.2	1.2	1.5	1.1	-1.2	-1.1	-0.9
Intermittent access intake escalation 2	2.6	2.5	3.4	1.8	-1.9	-1.8	-0.3
Intermitt. access day 1 inactive lever presses	1.4	1.5	4.0	1.0	-0.8	-0.7	-2.0
Intermitt. access day 15 inactive lever presses	0.7	0.7	1.7	0.7	-0.7	-0.6	-1.3
Intermitt. access escalation Index	0.1	0.0	0.1	0.2	0.1	-0.2	0.3
Intermittent access day 1 total infusions	1.0	1.2	4.0	-0.5	0.6	0.2	2.0
Intermittent access day 15 total infusions	0.5	0.6	0.9	0.8	-0.8	-0.9	0.5
Intermittent access terminal intake (last 3 days)	1.1	1.2	1.5	1.0	-1.1	-1.2	0.9
Intermittent access total infusions	0.5	0.6	1.3	0.4	-0.5	-0.8	1.2
Intermittent access day 1 locomotion	0.6	0.7	2.4	-0.4	0.2	0.1	1.6
Intermittent access day 15 total locomotion	0.0	0.0	0.1	-0.2	-0.1	0.2	0.3
Intermittent access total locomotion	0.5	0.6	1.1	-0.9	0.4	0.6	1.0
Intermittent access standard deviation	4.9	5.2	6.6	2.6	-2.3	-2.5	-1.7
Left kidney weight	2.2	6.1	8.1	2.5	-2.7	-2.8	1.5
Right kidney weight	3.1	8.8	12.0	3.5	-3.4	-3.4	-0.1
Cocaine induced anxiety	0.4	0.4	1.6	0.2	-0.3	-0.1	-1.3
Post-drug Anxiety	0.6	0.7	2.3	-0.4	0.1	0.6	-1.5
Baseline Anxiety	0.7	0.8	2.2	-0.6	0.6	0.4	1.5
Tail length	4.7	14.2	18.4	4.3	-4.2	-4.0	-2.1
Length with tail	6.7	24.5	32.7	5.7	-5.6	-5.2	-2.6
Length without tail	2.9	6.4	9.0	3.0	-2.8	-2.7	-1.2
Times rat made contact with spout	0.9	1.0	2.3	-0.9	0.7	0.6	1.5
Lifetime Intake	0.4	0.4	1.6	-0.1	0.1	-0.2	1.3
Liver weight, left	0.5	0.8	2.7	-0.6	0.2	0.2	1.6
Liver weight, right	0.1	0.1	0.4	-0.0	-0.1	-0.1	0.6
Locomotor activity	0.5	0.8	1.1	-0.9	0.8	0.7	1.1
Locomotor testing distance	0.7	1.2	1.7	-1.2	1.3	1.1	0.5
Locomotor testing rearing	1.5	2.4	2.7	-1.7	1.6	1.5	1.4
Locomotion in novel chamber	0.3	0.4	0.5	-0.5	0.7	0.7	-0.7
Locomotion in novel chamber post-restriction	0.6	0.7	2.6	0.4	0.2	-0.0	-1.6
Fecal boli incidents, locomotor time 1	2.4	2.6	3.7	-1.7	1.7	1.9	-0.9
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.4	-0.3	-0.3	0.3
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	-0.1	0.1	0.1	0.0
Bouts of movement, locomotor time 1	2.2	2.4	8.1	1.0	-0.6	-0.5	-2.8
Total resting periods, locomotor time 1	2.3	2.5	8.9	0.9	-0.4	-0.4	-3.0
Rest time, locomotor task time 1	0.0	0.0	0.1	-0.2	0.2	0.2	-0.1
Distance moved, locomotor task time 1	0.4	0.4	1.5	0.1	-0.3	-0.3	1.2
Vertical activity count, locomotor time 1	0.8	0.9	1.2	1.0	-1.1	-1.1	0.4
Time >=10cm from walls, locomotor time 2	0.3	0.3	1.2	-0.1	-0.1	-0.1	1.1
Bouts of movement, locomotor time 2	1.1	1.2	4.6	-0.1	0.0	0.5	-2.1
Total resting periods, locomotor time 2	0.8	0.8	2.9	-0.2	0.1	0.6	-1.7
Rest time, locomotor task time 2	0.3	0.3	0.7	0.4	-0.2	-0.6	0.9
Distance moved, locomotor task time 2	0.2	0.2	0.7	-0.4	0.0	0.2	0.8
Vertical activity count, locomotor time 2	0.3	0.3	0.5	0.5	-0.6	-0.4	-0.7
Light reinforcement 1	0.1	0.1	0.3	-0.5	0.4	0.4	0.2
Light reinforcement 2	5.1	6.9	9.7	-2.9	3.0	3.1	-0.5
Bone: marrow area	1.2	2.6	3.2	1.8	-1.8	-1.7	-1.0
Bone: maximum diameter	1.2	2.1	2.9	1.6	-1.7	-1.7	-0.3
Bone: maximum force	2.2	3.8	5.3	2.3	-2.2	-2.3	-0.3
Bone: maximum moment	2.9	5.1	6.9	2.6	-2.6	-2.6	-0.3
Mean time between licks in bursts	0.1	0.1	0.2	0.4	-0.4	-0.2	0.3
Mean num. licks in bursts	0.7	0.8	1.3	1.0	-1.1	-1.0	-0.1
Cd content in liver	0.3	0.3	0.4	-0.5	0.7	0.6	-0.5
Co content in liver	1.5	1.7	2.5	-1.5	1.6	1.5	0.0
Cu content in liver	0.8	1.0	1.3	1.1	-1.1	-1.2	0.3
Fe content in liver	0.3	0.4	0.6	-0.5	0.5	0.6	-0.8
K content in liver	0.6	0.5	0.8	0.6	-0.7	-0.7	0.9
Mg content in liver	0.5	0.5	2.0	-0.1	-0.1	-0.0	1.4
Mn content in liver	2.2	2.5	9.5	0.1	-0.4	-0.6	3.1
Na content in liver	4.1	4.3	6.1	2.3	-2.5	-2.4	0.3
Rb content in liver	0.0	0.0	0.0	0.1	-0.1	0.0	-0.2
Se content in liver	5.1	6.3	9.7	-2.5	2.2	2.0	3.1
Sr content in liver	0.8	0.7	0.9	-0.9	0.9	0.8	0.7
Zn content in liver	0.2	0.3	0.4	-0.6	0.6	0.6	0.1
Bone: minimum diameter	4.3	8.1	10.9	3.3	-3.2	-3.3	-0.5
Time in familiar zone, hab. session 1	0.3	0.3	0.5	0.5	-0.6	-0.7	-0.3
Time in novel zone, hab. session 1	0.3	0.3	0.4	-0.5	0.5	0.5	0.7
Total zone transitions, hab. session 1	0.5	0.7	1.0	0.7	-0.9	-1.0	0.6
Total locomotion distance, hab. session 1	2.7	3.8	5.0	2.2	-2.2	-2.2	-0.8
Locomotion velocity, hab. session 1	1.2	1.7	2.2	1.4	-1.4	-1.5	-0.7
Time in familiar zone, hab. session 2	1.5	1.5	4.1	1.0	-0.8	-0.7	-2.0
Time in novel zone, hab. session 2	0.9	0.9	1.2	-0.9	0.8	0.8	1.1
Total zone transitions, hab. session 2	1.3	1.7	6.1	-0.7	0.4	0.1	2.5
Total locomotion distance, hab. session 2	0.3	0.4	0.6	0.6	-0.6	-0.8	0.7
Locomotion velocity, hab. session 2	0.4	0.5	1.2	0.4	-0.5	-0.7	1.1
Novel to familiar place preference ratio	1.0	1.0	1.5	1.0	-1.2	-1.2	0.4
Novelty place preference	0.9	0.9	1.4	0.9	-1.1	-1.2	0.5
Time in novel zone, NPP test	0.6	0.6	0.9	0.7	-0.8	-0.9	0.5
Total zone transitions, NPP test	0.1	0.1	0.2	-0.5	0.4	0.3	0.1
Total locomotion distance, NPP test	1.8	2.5	2.9	1.7	-1.6	-1.6	-1.4
Locomotion velocity, NPP test	2.1	3.0	3.7	1.9	-1.8	-1.8	-1.2
Intraocular pressure	0.1	0.2	0.7	-0.0	0.1	0.1	-0.8
Delta distance traveled before/after self-admin	1.9	2.1	5.2	1.2	-1.1	-0.8	-2.3
Delta ambulatory time before/after self-admin	1.5	1.7	1.9	1.3	-1.4	-1.1	-1.3
Parametrial fat weight	0.7	1.3	1.6	-1.2	1.1	1.1	1.2
Pavlov. Cond. lever latency	0.5	0.6	2.0	-0.1	0.4	0.5	-1.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.4	0.5	0.3	0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.0	0.0	-0.1	0.4
Pavlov. Cond. index score	0.3	0.4	1.7	-0.2	0.0	-0.1	1.3
Pavlov. Cond. latency score	0.2	0.3	1.2	-0.0	-0.2	-0.2	1.1
Pavlov. Cond. lever contacts	0.6	0.8	1.0	0.8	-1.0	-1.0	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.4	-0.4	-0.2	-0.5
Pavlov. Cond. intertrial magazine entries	0.4	0.4	1.1	-0.5	0.4	0.4	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	2.6	-0.1	-0.1	-0.3	1.6
Pavlov. Cond. response bias	0.1	0.2	0.4	0.2	-0.2	-0.4	0.6
Pavlov. Cond. lever latency	3.3	4.5	5.7	-2.4	2.1	2.2	1.8
Pavlov. Cond. magazine entry latency	2.2	2.5	2.8	1.7	-1.5	-1.5	-1.7
Pavlov. Cond. change in total contacts	6.2	8.6	11.2	3.3	-2.9	-3.0	-2.4
Pavlov. Cond. index score	3.5	4.5	5.2	2.3	-2.0	-2.0	-2.2
Pavlov. Cond. latency score	3.3	4.1	4.8	2.2	-1.9	-1.9	-2.1
Pavlov. Cond. lever contacts	3.2	4.3	5.5	2.3	-2.0	-2.1	-1.8
Pavlov. Cond. magazine entry number	2.3	2.8	5.5	-1.6	1.3	1.3	2.3
Pavlov. Cond. intertrial magazine entries	1.5	2.0	3.2	-1.4	1.3	1.1	1.8
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.6	5.6	2.4	-2.1	-2.1	-1.9
Pavlov. Cond. response bias	3.5	4.8	6.2	2.5	-2.2	-2.2	-1.8
Time in closed arm before self-admin	0.4	0.5	0.8	-0.4	0.8	0.5	0.9
Time in closed arm after self-admin	0.5	0.5	1.4	0.6	-0.4	-0.2	-1.2
Time in open arm before self-admin	1.4	1.5	2.2	1.3	-1.5	-1.3	-0.6
Time in open arm after self-admin	1.1	1.3	2.6	0.7	-0.8	-1.1	1.6
Bone: periosteal estimation	1.7	3.6	4.8	2.2	-2.1	-2.2	-0.6
Bone: periosteal perimeter	1.7	2.8	3.6	1.9	-1.8	-1.8	-1.0
Bone: post-yield work	1.1	1.4	2.1	1.2	-1.1	-1.0	-1.5
Progressive ratio test 1 active lever presses	0.8	0.9	1.1	1.1	-0.7	-1.0	0.9
Progressive ratio test 1 breakpoint	1.1	1.2	1.7	1.3	-0.9	-1.2	0.8
Progressive ratio test 1 inactive lever presses	0.7	0.7	1.2	0.7	-0.9	-0.6	-1.1
Progressive ratio test 2 active lever presses	0.4	0.4	0.6	0.7	-0.7	-0.7	-0.0
Progressive ratio test 2 breakpoint	0.4	0.4	0.6	0.7	-0.7	-0.8	0.3
Progressive ratio test 2 inactive lever presses	2.8	3.2	4.0	2.0	-1.8	-1.8	-1.5
Incentive Sensitization - Responses	0.1	0.1	0.4	0.1	-0.3	-0.1	-0.6
Incentive Sensitization - Breakpoint	0.1	0.1	0.5	-0.1	-0.2	0.1	-0.7
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.2	-0.1	-0.0	0.1
Progressive ratio	0.3	0.4	0.9	-0.5	0.3	0.5	-1.0
Food seeking constrained by brief footshock	2.5	3.1	4.3	2.1	-1.9	-1.9	-1.0
Seeking ratio, punishment vs. effort	1.1	1.3	2.3	1.5	-1.0	-1.3	0.2
Retroperitoneal fat weight	1.3	4.2	5.8	-2.2	1.8	1.7	2.4
Reaction time number correct	0.5	0.7	2.9	-0.1	-0.0	-0.1	1.7
Reaction time mean minus median	0.1	0.1	0.2	0.4	-0.4	-0.4	0.2
Reaction time mean minus median AUC	0.2	0.2	0.3	0.5	-0.5	-0.5	0.4
Reaction time num false alarms	0.9	1.2	1.6	-1.3	1.0	1.1	0.9
Reaction time num false alarms AUC	1.2	1.7	2.2	-1.5	1.3	1.4	1.0
Reaction time trials correct on left	0.5	0.7	2.9	-0.1	-0.0	-0.1	1.7
Reaction time trials on left	0.5	0.8	3.0	-0.2	0.0	-0.1	1.7
Reaction time mean	0.1	0.1	0.1	-0.3	0.4	0.3	0.2
Reaction time mean AUC	0.2	0.3	0.3	-0.5	0.6	0.5	0.5
Median of all reaction times	0.2	0.2	0.4	-0.5	0.6	0.5	0.2
Reaction time omissions	0.3	0.3	0.4	-0.6	0.6	0.6	0.5
Reaction time false alarm rate	0.8	1.1	1.6	-1.2	1.1	1.3	-0.2
Reaction time premature initiation rate	0.1	0.2	0.7	0.2	-0.1	-0.1	-0.9
Reaction time premature initiations	0.0	0.0	0.0	0.1	-0.0	-0.1	0.1
Std. dev. reaction times	0.0	0.1	0.1	0.3	-0.1	-0.2	0.3
Reaction time trials completed	0.5	0.8	3.0	-0.2	0.0	-0.1	1.7
Reaction time trials AUC	0.7	1.0	3.8	-0.3	0.2	0.0	2.0
Run reversals in cocaine runway, females	0.3	0.3	0.4	-0.4	0.5	0.5	-0.6
Run reversals in cocaine runway, males	1.5	1.4	2.3	-1.1	1.5	1.2	1.0
Latency to leave start box in cocaine runway	0.0	0.0	0.0	-0.2	-0.0	0.2	-0.0
Latency to leave start box in cocaine runway, F	0.3	0.4	0.6	-0.7	0.6	0.7	0.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	-0.4	-0.3	-0.3
Std. dev. time between licks in bursts	0.9	1.1	1.4	1.1	-1.1	-0.8	-1.2
Total sessions with >9 infusions	1.8	2.0	7.2	-0.7	0.4	0.3	2.7
Short access day 1 total inactive lever presses	0.9	1.0	1.6	0.9	-0.9	-0.8	-1.3
Short access day 10 total inactive lever presses	1.6	1.8	5.3	0.9	-0.8	-0.6	-2.3
Short access day 1 total infusions	0.4	0.4	1.4	0.3	-0.0	-0.4	1.2
Short access day 10 total infusions	0.6	0.7	1.9	-0.6	0.6	0.4	1.4
Short access total infusions	1.1	1.2	3.6	-0.8	0.7	0.4	1.9
Short access day 1 locomotion	1.7	1.8	2.7	-1.5	1.0	1.2	1.6
Short access day 10 total locomotion	0.4	0.4	0.9	0.5	-0.9	-0.7	0.3
Short access total locomotion	1.1	1.1	3.8	-0.8	0.1	0.3	1.9
One hour access (0.3 mA shock)	1.3	1.6	2.0	1.3	-1.4	-1.3	-0.9
Compulsive drug intake	0.4	0.4	0.6	0.7	-0.6	-0.6	-0.8
One hour access (shock baseline)	0.1	0.1	0.3	0.4	-0.5	-0.4	-0.0
Social response proportion	3.1	3.3	4.8	2.2	-2.0	-2.1	-0.2
Social responses	0.2	0.3	0.9	0.5	-0.3	-0.2	-0.9
Social time	1.3	1.7	4.3	1.1	-0.8	-0.8	-2.1
Soleus weight	0.6	1.8	2.3	-1.4	1.5	1.5	-0.8
Bone: stiffness	1.2	1.8	2.4	1.6	-1.5	-1.5	-0.4
Tibialis anterior weight	0.0	0.1	0.4	-0.1	-0.0	-0.0	0.6
Time to tail flick, vehicle, before self-admin	1.3	1.3	5.0	-0.2	-0.4	-0.4	2.2
Time to tail flick, vehicle, after self-admin	0.4	0.4	1.1	0.6	-0.2	-0.3	-1.0
Time to tail flick, test, before self-admin	0.6	0.6	2.3	-0.2	-0.1	0.1	1.5
Time to tail flick, test, after self-admin	0.2	0.3	0.9	-0.2	-0.3	-0.0	0.9
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.6	0.6	-0.0	-0.1	-1.3
Delta time to tail flick, test, before/after SA	0.1	0.1	0.4	-0.2	-0.1	-0.0	0.6
Tibia length	1.5	4.3	5.8	2.4	-2.4	-2.3	-0.2
Ambulatory time before self-admin	0.7	0.7	1.1	1.0	-0.8	-1.0	0.2
Ambulatory time after self-admin	5.2	5.7	7.6	2.8	-2.6	-2.5	-1.4
Bone: tissue strength	3.5	3.4	4.5	2.1	-2.1	-2.1	-0.5
Total heroin consumption	1.2	1.4	2.2	1.4	-1.3	-1.5	-0.0
Bone: trabecular number	0.1	0.2	0.3	0.4	-0.5	-0.4	-0.5
Bone: trabecular spacing	1.3	1.6	2.2	1.5	-1.5	-1.5	-0.1
Bone: trabecular thickness	0.4	0.5	1.0	-0.6	0.5	0.5	1.0
Bone: trabecular tissue density	2.0	2.9	3.9	-2.0	1.9	1.8	0.7
Water consumed over 24 hours	0.7	0.9	1.2	0.7	-0.9	-0.9	1.1
Number of responses in last shaping day	1.5	1.5	2.1	1.4	-1.3	-1.4	0.7