Hub : Genes

Ppp1r13l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL isoform ratio NM_001427130.1 0.2 0.15 5.8e-04 0.1 0.14 0.15 0.14 1.7e-03 3.2e-04 1.9e-04 2.5e-04
2 Brain alternative TSS NM_001427130.1 0.06 0.06 1.1e-04 0.04 0.03 0.02 0.03 1.9e-04 6.5e-04 4.7e-03 7.2e-04
3 NAcc gene expression Ppp1r13l 0.03 0.03 1.4e-04 0.01 0.01 0.01 0.01 2.0e-03 3.8e-03 1.4e-02 5.3e-03
4 NAcc mRNA stability Ppp1r13l 0.03 0.03 3.1e-04 0.02 0.02 0.02 0.01 6.5e-04 1.2e-03 1.4e-03 2.4e-03
5 NAcc isoform ratio NM_001427130.1 0.05 0.05 1.7e-05 0.02 0.02 0.01 0.01 1.7e-03 1.3e-04 4.0e-03 4.4e-03
6 PL alternative TSS XM_063274161.1 0.04 0.04 1.9e-05 0.04 0.04 0.04 0.04 3.2e-05 4.0e-05 9.1e-05 5.5e-05
7 PL gene expression Ppp1r13l 0.04 0.04 3.3e-05 0.04 0.04 0.04 0.03 5.8e-05 5.1e-05 7.8e-05 1.1e-04
8 NAcc alternative TSS XM_063274161.1 0.02 0.02 5.1e-03 0.01 0.01 0.01 0.01 4.9e-03 6.8e-03 6.2e-03 7.6e-03
9 NAcc alternative TSS NM_001427130.1 0.05 0.04 5.2e-07 0.03 0.04 0.03 0.03 2.7e-05 9.1e-07 5.5e-06 7.7e-06
10 Brain alternative TSS XM_063274161.1 0.07 0.07 1.1e-05 0.04 0.05 0.04 0.05 5.3e-05 1.5e-05 6.2e-05 2.8e-05
11 Brain isoform ratio XM_063274170.1 0.02 0.03 7.8e-03 0.02 0.02 0.02 0.02 5.4e-03 4.3e-03 5.8e-03 5.7e-03
12 PL mRNA stability Ppp1r13l 0.04 0.04 7.5e-04 0.03 0.03 0.02 0.03 3.6e-04 8.9e-04 2.5e-03 8.2e-04
13 Brain isoform ratio NM_001427130.1 0.07 0.06 4.7e-07 0.07 0.07 0.06 0.07 6.0e-07 5.7e-07 1.2e-06 6.3e-07
14 PL isoform ratio NM_001427130.1 0.07 0.06 1.7e-08 0.06 0.06 0.06 0.06 1.4e-07 1.3e-07 1.8e-07 1.8e-07
15 Brain gene expression Ppp1r13l 0.03 0.03 9.4e-03 0.02 0.02 0.02 0.01 1.1e-02 8.9e-03 1.2e-02 1.4e-02
16 PL isoform ratio XM_063274170.1 0.04 0.04 1.5e-04 0.03 0.03 0.03 0.03 3.7e-04 3.0e-04 3.8e-04 4.8e-04
17 Liver gene expression Ppp1r13l 0.02 0.02 3.2e-03 0.01 0.01 0.01 0.01 2.3e-02 3.1e-02 3.2e-02 6.0e-02
18 PL alternative TSS NM_001427130.1 0.04 0.04 1.9e-05 0.04 0.03 0.03 0.03 5.5e-05 1.1e-04 1.4e-04 1.4e-04
19 IL alternative TSS NM_001427130.1 0.12 0.11 6.9e-03 0.11 0.09 0.11 0.1 1.2e-03 3.3e-03 1.3e-03 2.7e-03
20 BLA isoform ratio NM_001427130.1 0.11 0.14 3.3e-03 0.03 0.01 0 0.03 8.3e-03 8.5e-02 2.4e-01 1.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density0.00.00.2-0.1-0.2-0.20.2-0.10.2-0.00.1-0.0-0.10.0-0.20.00.00.0-0.00.20.1-0.2-0.4
Area under the delay curve1.32.02.71.61.41.3-1.3-1.41.3-1.41.4-1.4-1.41.4-1.5-1.4-1.4-1.41.51.41.31.61.7
BMI with tail0.51.82.6-1.4-1.2-1.31.31.3-1.41.4-1.41.41.3-1.41.21.41.41.4-1.4-1.4-1.3-1.4-1.6
BMI without tail0.31.82.2-1.5-1.2-1.41.41.4-1.41.4-1.41.41.4-1.41.31.31.31.3-1.3-1.4-1.4-1.4-1.2
Body weight1.14.85.5-2.3-2.1-2.12.12.2-2.22.2-2.32.22.2-2.22.12.22.22.2-2.2-2.2-2.1-2.1-2.3
Weight adjusted by age0.00.00.00.00.00.0-0.00.0-0.10.0-0.10.00.0-0.0-0.00.00.00.0-0.0-0.10.00.00.1
Bone surface0.20.51.0-0.8-0.7-0.70.70.6-0.60.7-0.60.60.6-0.70.60.70.70.7-0.7-0.5-0.5-0.8-1.0
Bone volume0.20.30.7-0.7-0.7-0.70.70.5-0.40.5-0.40.50.4-0.50.40.60.60.6-0.6-0.4-0.4-0.8-0.9
Breakpoint value in progressive ratio session1.52.73.21.81.71.7-1.7-1.61.7-1.61.7-1.6-1.61.6-1.5-1.6-1.6-1.61.61.61.61.61.5
Number of licking bursts1.23.64.4-1.9-1.7-1.71.72.0-2.11.9-2.12.02.0-1.92.11.91.91.9-1.9-2.1-2.1-1.5-1.7
Context. condit. distance diff. score0.10.10.2-0.4-0.2-0.30.30.4-0.40.4-0.30.40.4-0.40.30.40.40.4-0.4-0.3-0.5-0.4-0.4
Locomotion velocity, session 10.10.10.20.40.30.3-0.3-0.20.2-0.30.3-0.2-0.20.3-0.3-0.3-0.2-0.30.30.30.10.30.1
Locomotion distance, session 10.10.10.4-0.2-0.4-0.40.40.2-0.20.2-0.10.20.1-0.20.10.20.20.2-0.2-0.1-0.0-0.4-0.7
Locomotion velocity, session 21.21.41.8-1.2-1.0-1.01.01.3-1.31.2-1.31.21.3-1.21.21.21.21.2-1.2-1.3-1.3-1.1-1.0
Locomotion distance, session 20.30.40.8-0.7-0.8-0.80.80.6-0.60.6-0.50.60.6-0.60.50.70.70.7-0.7-0.5-0.5-0.8-0.9
Locomotion velocity, session 30.20.20.3-0.6-0.5-0.50.50.5-0.50.5-0.50.50.5-0.50.40.50.50.5-0.5-0.5-0.5-0.5-0.3
Locomotion distance, session 30.70.81.00.91.01.0-1.0-0.90.9-0.90.9-0.9-0.90.9-0.9-0.9-0.9-0.90.90.90.90.80.8
Stereotopy head waving bouts, day 30.81.01.6-1.0-0.8-0.70.71.1-1.11.0-1.11.01.1-1.01.11.01.01.0-0.9-1.1-1.3-0.7-0.3
Stereotopy head waving duration, day 31.01.21.6-1.2-1.0-1.01.01.2-1.21.1-1.21.11.2-1.11.21.11.11.1-1.1-1.2-1.3-1.0-0.7
Locomotion velocity, session 70.10.20.30.30.40.6-0.6-0.40.4-0.40.4-0.4-0.40.4-0.4-0.3-0.3-0.30.30.40.50.10.1
Locomotion distance, session 70.00.00.1-0.20.00.0-0.00.2-0.20.2-0.20.20.1-0.20.20.20.20.2-0.2-0.2-0.0-0.3-0.3
Stereotopy head waving bouts, day 70.91.11.4-1.1-1.1-1.01.01.0-1.01.0-1.01.01.0-1.01.11.01.01.0-1.0-1.0-1.2-1.0-0.9
Stereotopy head waving duration, day 70.70.91.2-1.0-1.0-0.90.91.0-0.91.0-1.01.01.0-1.01.00.91.01.0-0.9-1.0-1.1-0.8-0.8
Locomotion velocity, session 80.00.00.10.10.10.2-0.2-0.0-0.1-0.00.0-0.0-0.00.1-0.1-0.1-0.1-0.10.10.0-0.00.10.3
Locomotion distance, session 80.00.00.2-0.2-0.1-0.10.10.1-0.10.10.00.10.1-0.1-0.00.20.20.1-0.20.0-0.1-0.4-0.4
Degree of sensitization distance0.50.60.7-0.8-0.7-0.70.70.8-0.80.8-0.80.80.8-0.80.80.80.80.8-0.8-0.8-0.8-0.8-0.7
Degree of sensitization stereotypy1.01.11.4-1.1-1.2-1.11.11.1-1.01.1-1.01.11.1-1.11.11.11.11.1-1.1-1.0-1.1-1.0-1.0
Conditioned locomotion0.00.00.10.20.20.1-0.1-0.20.2-0.20.2-0.2-0.20.2-0.3-0.2-0.2-0.20.20.20.30.20.2
Cocaine response after cond. corrected0.50.71.3-0.9-0.8-0.80.80.8-0.80.8-0.80.80.8-0.80.90.80.90.9-0.9-0.8-0.8-0.8-1.1
Cocaine response after cond. not corrected1.21.83.1-1.4-1.3-1.21.21.3-1.31.3-1.31.31.3-1.31.31.31.31.3-1.4-1.3-1.3-1.3-1.8
Cocaine response before conditioning1.51.92.1-1.4-1.3-1.31.31.4-1.51.4-1.41.41.4-1.41.31.41.41.4-1.4-1.4-1.3-1.4-1.4
Saline control response2.02.83.6-1.9-1.8-1.71.71.7-1.71.7-1.61.71.7-1.71.71.71.71.7-1.7-1.7-1.7-1.7-1.4
Bone: connectivity density0.00.00.10.1-0.1-0.00.0-0.30.3-0.20.3-0.2-0.30.2-0.3-0.1-0.1-0.20.10.40.3-0.1-0.2
Bone: cortical apparent density0.10.10.20.20.30.4-0.4-0.30.4-0.30.4-0.3-0.30.3-0.4-0.3-0.3-0.30.30.40.20.10.3
Bone: cortical area1.52.42.8-1.7-1.5-1.51.51.6-1.61.6-1.61.61.6-1.61.61.61.61.6-1.6-1.6-1.5-1.5-1.4
Bone: cortical porosity0.20.20.50.50.60.5-0.5-0.40.4-0.40.4-0.4-0.40.4-0.3-0.5-0.5-0.50.50.30.30.60.7
Bone: cortical porosity0.00.00.20.10.20.1-0.1-0.00.1-0.10.0-0.00.00.10.1-0.1-0.1-0.10.1-0.1-0.10.20.5
Bone: cortical thickness0.61.01.3-1.1-1.0-1.01.01.0-1.01.0-1.01.01.0-1.00.91.01.01.0-1.0-1.0-0.9-1.0-0.8
Bone: cortical thickness1.41.71.9-1.4-1.3-1.41.41.3-1.41.3-1.41.31.3-1.31.21.31.31.3-1.3-1.2-1.3-1.4-1.2
Bone: cortical tissue density0.10.20.30.30.40.5-0.5-0.50.5-0.40.5-0.5-0.50.4-0.5-0.4-0.4-0.40.40.50.30.20.4
Condit. Reinf. active minus inactive responses0.40.40.8-0.7-0.5-0.70.70.6-0.50.6-0.60.60.6-0.60.50.70.70.7-0.7-0.6-0.7-0.7-0.9
Condit. Reinf. active-inactive response ratio0.30.31.0-0.7-0.6-0.60.60.4-0.40.5-0.40.50.4-0.50.30.60.60.6-0.6-0.4-0.6-0.7-1.0
Condit. Reinf. active responses0.20.30.5-0.6-0.5-0.60.60.4-0.40.5-0.40.50.4-0.50.30.50.50.5-0.6-0.4-0.5-0.7-0.7
Condit. Reinf. inactive responses0.00.00.10.1-0.10.0-0.0-0.20.2-0.20.2-0.2-0.20.1-0.3-0.1-0.1-0.10.10.20.4-0.10.1
Incentive salience index mean0.20.20.4-0.5-0.4-0.40.40.4-0.40.5-0.40.50.4-0.50.40.50.50.5-0.5-0.4-0.5-0.6-0.7
Condit. Reinf. lever presses0.00.00.0-0.10.00.0-0.00.1-0.10.1-0.10.10.1-0.10.10.10.10.1-0.1-0.1-0.1-0.1-0.2
Condit. Reinf. active minus inactive responses0.10.10.3-0.4-0.3-0.50.50.3-0.30.3-0.30.30.3-0.30.20.30.30.3-0.3-0.3-0.3-0.4-0.5
Condit. Reinf. active-inactive response ratio0.40.61.1-0.8-0.8-0.80.80.7-0.60.7-0.60.70.7-0.70.60.70.70.7-0.8-0.7-0.7-0.8-1.1
Condit. Reinf. active responses0.10.10.20.30.30.1-0.1-0.30.3-0.30.2-0.3-0.30.3-0.4-0.3-0.3-0.30.30.30.30.30.4
Condit. Reinf. inactive responses0.71.02.01.11.00.9-0.9-0.90.8-1.00.9-1.0-0.91.0-1.0-1.0-1.0-1.01.00.91.01.01.4
Condit. Reinf. lever presses0.10.20.4-0.4-0.4-0.60.60.4-0.50.4-0.50.40.4-0.40.30.40.50.4-0.5-0.5-0.3-0.4-0.5
Condit. Reinf. lever reinforcers received0.10.10.20.40.40.2-0.2-0.30.3-0.30.3-0.3-0.30.3-0.4-0.3-0.3-0.40.30.30.40.40.5
Conditioned reinforcement - actives0.62.22.5-1.6-1.5-1.51.51.5-1.51.5-1.51.51.5-1.51.41.51.51.5-1.5-1.4-1.4-1.5-1.5
Conditioned reinforcement - inactives0.20.50.7-0.8-0.7-0.70.70.8-0.70.7-0.70.70.8-0.70.80.70.70.7-0.7-0.8-0.8-0.7-0.5
Conditioned locomotion2.13.13.4-1.8-1.8-1.81.81.7-1.81.7-1.81.71.7-1.71.71.71.81.7-1.8-1.7-1.7-1.7-1.8
Patch foraging indifference point 0 sec0.30.81.1-0.9-1.0-1.01.00.9-0.90.9-0.90.90.9-0.90.90.90.90.9-0.9-0.8-0.9-0.8-0.8
Patch foraging indifference point AUC1.84.25.0-2.2-2.0-2.02.02.1-2.12.1-2.22.12.1-2.12.22.02.02.0-2.0-2.2-2.1-2.0-1.7
Delay disc. indifference point, 0s delay1.31.51.91.31.21.1-1.1-1.21.2-1.21.2-1.2-1.21.2-1.2-1.2-1.2-1.21.21.21.21.31.4
Delay disc. indifference point, 16s delay0.91.31.81.31.21.1-1.1-1.11.1-1.11.1-1.1-1.11.1-1.2-1.1-1.1-1.11.11.11.01.21.3
Delay disc. indifference point, 2s delay3.74.15.72.31.91.9-1.9-2.01.9-2.01.9-2.0-1.92.0-2.1-2.1-2.1-2.12.11.91.82.42.2
Delay disc. indifference point, 24s delay0.10.10.3-0.3-0.4-0.30.30.2-0.30.2-0.20.20.2-0.3-0.00.30.30.3-0.3-0.2-0.0-0.3-0.6
Delay disc. indifference point, 4s delay0.00.00.10.10.0-0.10.1-0.0-0.0-0.0-0.0-0.00.00.0-0.1-0.1-0.1-0.10.1-0.00.00.20.3
Delay disc. indifference point, 8s delay1.22.02.61.51.31.3-1.3-1.41.4-1.41.4-1.4-1.41.4-1.4-1.4-1.4-1.41.41.41.31.61.6
Indifference point function ln k0.41.31.71.20.91.0-1.0-1.21.3-1.21.3-1.2-1.21.1-1.2-1.1-1.1-1.11.11.31.11.00.9
Indifference point function log k0.41.31.71.20.91.0-1.0-1.21.3-1.21.3-1.2-1.21.1-1.2-1.1-1.1-1.11.11.31.11.00.9
Patch foraging total patch changes 0 sec0.41.32.0-1.2-1.4-1.31.31.1-1.11.1-1.01.11.1-1.11.11.11.11.1-1.1-1.0-1.1-1.1-1.1
Patch foraging total patch changes 12 sec1.31.71.9-1.3-1.2-1.31.31.3-1.31.3-1.41.31.3-1.31.41.31.31.3-1.3-1.4-1.3-1.1-1.2
Patch foraging total patch changes 18 sec1.33.14.1-1.9-2.0-2.02.01.7-1.71.7-1.61.71.7-1.71.81.71.71.7-1.7-1.6-1.7-1.7-1.9
Patch foraging total patch changes 24 sec0.10.50.8-0.8-0.9-0.80.80.7-0.70.7-0.60.70.7-0.70.70.70.70.7-0.7-0.6-0.7-0.6-0.6
Patch foraging total patch changes 6 sec2.33.94.8-2.2-2.2-2.22.22.0-2.02.0-2.01.92.0-2.02.01.91.91.9-1.9-1.9-1.9-2.0-1.6
Patch foraging time to switch 0 sec1.45.56.52.62.52.4-2.4-2.32.4-2.32.3-2.3-2.32.4-2.2-2.4-2.4-2.42.42.22.22.42.2
Patch foraging water rate 0 sec1.76.37.3-2.7-2.6-2.62.62.5-2.62.5-2.42.52.5-2.52.42.52.52.5-2.5-2.4-2.4-2.6-2.3
Patch foraging water rate 12 sec0.10.30.6-0.6-0.8-0.60.60.5-0.50.5-0.40.50.5-0.50.40.60.60.6-0.6-0.4-0.5-0.7-0.7
Patch foraging water rate 18 sec0.10.20.5-0.6-0.7-0.60.60.4-0.40.5-0.30.40.4-0.50.30.50.50.5-0.5-0.3-0.4-0.6-0.3
Patch foraging water rate 24 sec0.60.91.2-1.0-1.1-1.11.10.9-1.00.9-0.90.90.9-0.90.80.90.90.9-0.9-0.8-0.8-1.0-0.9
Patch foraging water rate 6 sec0.71.11.6-1.2-1.2-1.11.11.0-1.01.0-0.91.01.0-1.00.81.01.01.0-1.0-0.9-0.9-1.3-1.1
Seeking ratio, delayed vs. immediate footshock1.62.32.61.61.51.6-1.6-1.61.6-1.51.6-1.5-1.51.5-1.5-1.5-1.5-1.51.51.61.51.41.4
Distance traveled before self-admin0.10.10.3-0.4-0.5-0.40.40.3-0.40.3-0.30.30.3-0.30.20.30.30.3-0.3-0.3-0.3-0.2-0.5
Distance traveled after self-admin0.10.20.20.40.30.4-0.4-0.40.4-0.40.4-0.4-0.40.4-0.5-0.4-0.4-0.40.40.40.50.40.5
Extensor digitorum longus weight1.87.08.3-2.9-2.7-2.62.62.7-2.52.7-2.52.72.6-2.72.72.72.72.7-2.7-2.6-2.8-2.5-2.5
Bone: elastic displacement1.01.31.71.11.21.3-1.3-1.11.2-1.11.3-1.1-1.11.1-1.0-1.1-1.1-1.11.11.20.81.01.2
Bone: elastic work0.00.00.1-0.2-0.1-0.10.10.1-0.10.1-0.00.10.1-0.10.10.10.10.1-0.1-0.1-0.2-0.2-0.0
Bone: endosteal estimation0.00.10.20.30.50.4-0.4-0.30.3-0.20.3-0.2-0.30.2-0.2-0.2-0.2-0.20.20.20.30.2-0.0
Bone: endosteal perimeter0.00.00.10.10.30.1-0.1-0.00.0-0.0-0.0-0.0-0.00.00.1-0.0-0.0-0.00.0-0.10.10.1-0.1
Epididymis fat weight0.20.91.21.01.11.1-1.1-0.90.8-0.90.8-0.9-0.90.9-0.8-0.9-0.9-0.90.90.90.91.00.9
Delta time in closed arm before/after self-admin0.10.10.20.40.40.2-0.2-0.30.2-0.30.3-0.3-0.30.3-0.4-0.3-0.3-0.30.30.40.30.20.3
Delta time in open arm before/after self-admin0.00.00.10.1-0.10.1-0.1-0.10.1-0.10.2-0.2-0.10.1-0.1-0.2-0.2-0.20.20.10.20.10.4
Diff in mean of infusions in LGA sessions0.91.71.91.41.31.3-1.3-1.31.3-1.31.3-1.3-1.31.3-1.2-1.3-1.3-1.31.31.31.31.21.1
Delay discount exponential model param1.11.42.0-1.4-1.1-1.11.11.2-1.11.2-1.11.21.1-1.21.31.21.21.2-1.2-1.1-1.1-1.4-1.4
Extinction: sum of active levers before priming0.00.10.20.30.40.3-0.3-0.20.3-0.30.3-0.2-0.20.3-0.1-0.3-0.3-0.30.30.20.20.10.4
Active lever presses in extinction session 60.10.10.2-0.3-0.2-0.20.20.3-0.20.3-0.20.30.3-0.30.40.20.30.3-0.2-0.2-0.2-0.4-0.5
Bone: final force0.30.60.7-0.8-0.7-0.70.70.8-0.80.8-0.80.80.8-0.80.80.80.80.8-0.8-0.8-0.7-0.7-0.6
Bone: final moment0.50.81.0-0.9-0.8-0.90.90.9-1.00.9-1.00.90.9-0.90.90.90.90.9-0.9-0.9-0.9-0.8-0.8
Food consumed during 24 hour testing period3.46.98.02.82.52.6-2.6-2.72.6-2.62.8-2.7-2.72.6-2.7-2.6-2.6-2.62.62.82.72.42.4
Glucose0.30.50.80.80.90.9-0.9-0.60.5-0.60.5-0.6-0.60.6-0.6-0.7-0.7-0.70.70.50.60.80.7
Heart weight2.23.54.0-2.0-1.8-1.81.81.9-1.91.9-1.91.91.9-1.91.91.91.91.9-1.8-1.9-1.8-1.8-1.8
Delay discount hyperbolic model param1.01.31.9-1.3-1.1-1.01.01.1-1.11.1-1.01.11.1-1.11.21.21.21.2-1.2-1.0-1.0-1.4-1.4
Intermittent access intake day 1-15 change0.00.20.2-0.4-0.4-0.40.40.4-0.40.4-0.40.40.4-0.40.30.40.40.4-0.4-0.4-0.3-0.4-0.3
Intermittent access intake escalation0.00.20.3-0.5-0.5-0.50.50.5-0.50.5-0.50.50.5-0.50.40.50.50.5-0.5-0.5-0.4-0.5-0.4
Intermittent access intake escalation 20.00.00.0-0.1-0.1-0.10.10.1-0.10.1-0.10.10.1-0.10.00.10.10.1-0.1-0.1-0.0-0.1-0.1
Intermitt. access day 1 inactive lever presses0.00.00.0-0.1-0.0-0.00.00.1-0.00.1-0.00.10.1-0.10.00.00.10.1-0.1-0.1-0.0-0.0-0.1
Intermitt. access day 15 inactive lever presses0.00.00.0-0.0-0.0-0.00.00.0-0.00.0-0.00.00.0-0.00.00.00.00.0-0.0-0.0-0.0-0.00.0
Intermitt. access escalation Index0.10.30.40.60.60.6-0.6-0.60.6-0.60.6-0.5-0.60.5-0.5-0.5-0.5-0.50.50.60.50.50.4
Intermittent access day 1 total infusions0.82.32.8-1.7-1.5-1.51.51.5-1.51.5-1.51.51.5-1.51.51.51.51.5-1.5-1.5-1.5-1.5-1.2
Intermittent access day 15 total infusions0.41.11.3-1.1-1.1-1.11.11.1-1.11.1-1.11.01.1-1.11.01.01.01.0-1.0-1.1-1.0-1.0-0.8
Intermittent access terminal intake (last 3 days)0.91.51.7-1.3-1.3-1.31.31.2-1.31.2-1.31.21.2-1.21.11.21.21.2-1.2-1.2-1.1-1.2-1.0
Intermittent access total infusions2.52.93.4-1.8-1.7-1.71.71.7-1.71.7-1.71.71.7-1.71.71.71.71.7-1.7-1.7-1.7-1.7-1.5
Intermittent access day 1 locomotion0.20.40.4-0.6-0.6-0.60.60.6-0.60.6-0.60.60.6-0.60.60.60.60.6-0.6-0.6-0.6-0.6-0.7
Intermittent access day 15 total locomotion0.10.20.3-0.5-0.5-0.50.50.5-0.50.5-0.50.50.5-0.50.50.50.50.5-0.5-0.5-0.5-0.5-0.3
Intermittent access total locomotion1.62.02.3-1.5-1.4-1.41.41.4-1.41.4-1.41.41.4-1.41.41.41.41.4-1.4-1.4-1.4-1.4-1.2
Intermittent access standard deviation0.00.20.30.50.40.4-0.4-0.40.4-0.50.4-0.5-0.40.5-0.5-0.5-0.5-0.50.50.40.50.50.6
Left kidney weight3.326.231.7-5.6-5.2-5.25.25.0-5.05.1-5.15.15.0-5.14.95.25.15.1-5.2-5.0-4.8-5.3-5.1
Right kidney weight3.423.627.8-5.3-4.9-4.94.94.8-4.84.9-4.84.94.8-4.94.74.94.94.9-4.9-4.8-4.7-4.9-4.9
Cocaine induced anxiety0.10.30.70.50.60.6-0.6-0.50.6-0.50.6-0.5-0.50.5-0.4-0.5-0.5-0.50.60.50.40.60.8
Post-drug Anxiety0.10.10.20.20.30.3-0.3-0.20.3-0.20.3-0.2-0.20.2-0.1-0.2-0.2-0.20.20.10.10.30.5
Baseline Anxiety0.00.00.0-0.0-0.0-0.00.00.0-0.00.0-0.00.00.0-0.00.00.00.00.0-0.0-0.1-0.0-0.0-0.1
Tail length0.31.41.7-1.3-1.2-1.31.31.2-1.21.2-1.21.11.2-1.11.21.11.11.1-1.1-1.1-1.2-1.1-0.9
Length with tail0.31.51.9-1.4-1.4-1.31.31.2-1.21.2-1.21.21.2-1.21.21.21.21.2-1.2-1.1-1.2-1.1-1.1
Length without tail0.21.22.4-1.1-1.2-1.11.11.0-1.01.1-1.01.11.0-1.11.01.11.11.1-1.1-1.0-0.9-1.0-1.5
Times rat made contact with spout0.00.00.2-0.0-0.1-0.00.0-0.10.2-0.10.2-0.1-0.10.0-0.2-0.0-0.0-0.0-0.00.20.1-0.2-0.4
Lifetime Intake2.32.93.4-1.8-1.7-1.71.71.7-1.71.7-1.71.71.7-1.71.71.71.71.7-1.7-1.7-1.7-1.7-1.4
Liver weight, left2.03.43.9-2.0-1.8-1.91.91.9-1.91.9-1.91.91.9-1.92.01.81.81.8-1.8-1.9-2.0-1.7-1.5
Liver weight, right1.32.22.9-1.7-1.6-1.61.61.4-1.41.5-1.41.51.4-1.51.41.51.51.5-1.5-1.4-1.4-1.6-1.6
Locomotor activity2.23.54.2-2.1-1.8-1.91.91.9-1.91.9-2.01.91.9-1.91.91.81.81.8-1.8-2.0-1.9-1.7-1.3
Locomotor testing distance0.92.22.7-1.7-1.5-1.51.51.5-1.41.5-1.51.51.5-1.51.61.41.41.4-1.4-1.5-1.5-1.4-0.9
Locomotor testing rearing2.48.810.4-3.2-3.0-3.03.03.0-3.03.0-3.03.03.0-3.03.02.92.92.9-2.9-3.0-3.0-2.8-2.7
Locomotion in novel chamber0.10.20.30.40.40.4-0.4-0.40.4-0.40.3-0.4-0.40.4-0.5-0.4-0.4-0.40.40.30.60.40.4
Locomotion in novel chamber post-restriction0.51.42.31.31.21.0-1.0-1.11.1-1.11.3-1.2-1.11.2-1.1-1.2-1.2-1.21.21.31.01.11.5
Fecal boli incidents, locomotor time 10.00.00.1-0.2-0.2-0.00.00.2-0.20.2-0.20.20.2-0.20.30.20.20.2-0.2-0.2-0.3-0.1-0.2
Change in fecal boli incidents, locomotor task0.80.81.11.00.90.8-0.8-0.90.8-0.90.9-0.9-0.90.9-0.9-0.9-0.9-0.90.90.90.91.11.0
Time >=10cm from walls, locomotor time 10.00.00.1-0.2-0.30.1-0.1-0.10.1-0.00.1-0.0-0.10.0-0.10.00.00.0-0.00.10.1-0.3-0.3
Bouts of movement, locomotor time 12.02.53.11.61.51.4-1.4-1.71.7-1.61.7-1.6-1.71.6-1.7-1.6-1.6-1.61.61.71.81.51.3
Total resting periods, locomotor time 12.93.34.01.91.71.7-1.7-1.91.9-1.91.9-1.9-1.91.8-1.9-1.8-1.8-1.81.81.92.01.71.6
Rest time, locomotor task time 10.10.20.40.40.40.5-0.5-0.50.5-0.40.5-0.5-0.50.4-0.4-0.4-0.4-0.40.40.50.60.30.3
Distance moved, locomotor task time 10.20.50.7-0.6-0.5-0.60.60.7-0.80.7-0.80.70.8-0.70.70.70.70.7-0.7-0.8-0.8-0.5-0.5
Vertical activity count, locomotor time 10.00.00.10.20.10.2-0.2-0.00.1-0.10.0-0.1-0.00.10.0-0.1-0.1-0.10.10.00.00.30.3
Time >=10cm from walls, locomotor time 20.00.10.20.40.40.3-0.3-0.20.2-0.30.2-0.3-0.20.3-0.2-0.3-0.3-0.30.30.20.20.40.3
Bouts of movement, locomotor time 22.16.98.12.82.72.6-2.6-2.72.7-2.72.7-2.7-2.72.7-2.8-2.6-2.6-2.62.62.72.72.51.9
Total resting periods, locomotor time 21.56.17.12.62.52.4-2.4-2.62.5-2.52.5-2.5-2.62.5-2.7-2.5-2.5-2.52.42.52.62.31.7
Rest time, locomotor task time 20.00.00.1-0.0-0.10.1-0.1-0.20.3-0.20.3-0.2-0.20.2-0.2-0.1-0.1-0.10.10.30.3-0.10.0
Distance moved, locomotor task time 20.60.81.2-0.7-0.7-0.90.91.0-1.00.9-1.01.01.0-0.90.90.90.90.9-0.9-1.0-1.1-0.6-1.0
Vertical activity count, locomotor time 20.10.10.40.50.50.4-0.4-0.30.3-0.30.2-0.3-0.30.3-0.2-0.4-0.3-0.30.40.20.20.60.3
Light reinforcement 10.00.20.4-0.6-0.5-0.40.40.3-0.20.4-0.20.30.3-0.40.40.40.40.4-0.4-0.3-0.3-0.6-0.5
Light reinforcement 20.00.10.2-0.4-0.3-0.30.30.3-0.20.3-0.30.30.3-0.30.40.30.30.3-0.3-0.3-0.2-0.5-0.2
Bone: marrow area0.00.00.20.20.40.3-0.3-0.20.3-0.20.2-0.2-0.20.2-0.1-0.2-0.2-0.10.10.10.20.1-0.1
Bone: maximum diameter2.04.14.6-2.1-1.7-1.91.92.0-2.02.1-2.12.12.0-2.02.12.02.02.1-2.1-2.1-2.0-2.0-2.1
Bone: maximum force0.10.30.4-0.5-0.5-0.60.60.5-0.60.5-0.60.50.5-0.50.50.50.50.5-0.5-0.5-0.4-0.5-0.4
Bone: maximum moment0.20.40.5-0.6-0.6-0.70.70.6-0.70.6-0.70.60.6-0.60.60.60.60.6-0.6-0.7-0.5-0.5-0.5
Mean time between licks in bursts0.00.10.10.30.0-0.00.0-0.30.3-0.30.3-0.3-0.30.3-0.3-0.3-0.3-0.30.30.30.30.30.3
Mean num. licks in bursts1.33.64.71.81.61.7-1.7-2.12.2-2.02.2-2.0-2.11.9-2.2-1.8-1.9-1.91.82.22.21.31.4
Cd content in liver0.00.00.10.10.10.2-0.2-0.30.3-0.20.3-0.2-0.30.2-0.3-0.1-0.1-0.10.10.20.30.1-0.3
Co content in liver1.31.51.91.41.21.3-1.3-1.21.2-1.21.2-1.2-1.21.2-1.2-1.2-1.2-1.21.21.21.21.41.0
Cu content in liver0.30.40.5-0.6-0.7-0.50.50.6-0.60.6-0.60.60.6-0.60.70.60.60.6-0.6-0.5-0.7-0.3-0.5
Fe content in liver4.96.06.7-2.6-2.4-2.52.52.5-2.62.5-2.62.52.5-2.52.52.42.42.4-2.4-2.5-2.5-2.1-2.0
K content in liver0.10.10.2-0.1-0.3-0.30.30.4-0.40.3-0.40.40.4-0.30.50.30.30.3-0.3-0.3-0.50.0-0.1
Mg content in liver0.40.50.6-0.6-0.6-0.70.70.8-0.80.7-0.80.70.8-0.70.80.70.70.7-0.7-0.7-0.8-0.4-0.5
Mn content in liver0.91.01.1-1.0-0.9-0.90.91.0-1.01.0-1.01.01.0-1.01.01.01.01.0-1.0-1.0-1.0-0.9-0.9
Na content in liver0.20.20.4-0.4-0.5-0.40.40.5-0.40.4-0.40.50.5-0.40.60.40.40.4-0.4-0.5-0.6-0.2-0.1
Rb content in liver0.10.10.3-0.3-0.4-0.40.40.3-0.20.3-0.20.30.3-0.30.30.40.40.4-0.4-0.2-0.3-0.4-0.5
Se content in liver3.74.34.9-2.2-2.0-2.12.12.2-2.22.1-2.22.12.2-2.12.22.02.02.0-2.0-2.2-2.2-1.8-1.5
Sr content in liver0.00.00.1-0.1-0.0-0.00.00.2-0.20.1-0.20.10.2-0.10.20.10.10.1-0.1-0.3-0.2-0.20.1
Zn content in liver0.70.81.1-0.8-0.9-0.70.70.9-0.90.9-0.90.90.9-0.91.00.90.90.9-0.9-0.8-1.0-0.7-1.1
Bone: minimum diameter0.20.30.4-0.6-0.5-0.50.50.6-0.50.6-0.50.60.6-0.60.60.60.60.6-0.6-0.6-0.5-0.5-0.5
Time in familiar zone, hab. session 10.20.20.3-0.4-0.3-0.20.20.4-0.50.4-0.50.40.4-0.40.50.40.40.4-0.4-0.5-0.5-0.3-0.4
Time in novel zone, hab. session 10.50.60.8-0.8-0.8-0.90.90.7-0.70.7-0.80.70.8-0.70.70.70.70.7-0.7-0.8-0.7-0.6-0.7
Total zone transitions, hab. session 10.20.30.5-0.6-0.7-0.70.70.5-0.40.5-0.40.50.5-0.50.40.50.50.5-0.5-0.4-0.4-0.7-0.6
Total locomotion distance, hab. session 10.40.50.60.80.50.5-0.5-0.70.7-0.70.7-0.7-0.70.7-0.8-0.7-0.7-0.70.70.70.70.70.8
Locomotion velocity, hab. session 11.11.61.91.41.11.0-1.0-1.31.3-1.31.3-1.3-1.31.3-1.4-1.3-1.3-1.31.31.31.31.31.3
Time in familiar zone, hab. session 20.20.30.4-0.5-0.5-0.60.60.5-0.50.5-0.50.50.5-0.50.60.50.50.5-0.4-0.5-0.7-0.3-0.4
Time in novel zone, hab. session 20.00.10.10.20.30.4-0.4-0.20.2-0.20.2-0.2-0.20.2-0.3-0.2-0.2-0.20.10.20.30.20.2
Total zone transitions, hab. session 20.50.60.7-0.8-0.8-0.80.80.8-0.80.8-0.80.80.8-0.80.90.80.80.8-0.8-0.8-0.8-0.7-0.8
Total locomotion distance, hab. session 20.50.70.91.00.80.8-0.8-0.80.8-0.80.8-0.8-0.80.8-0.8-0.9-0.9-0.90.90.80.71.00.7
Locomotion velocity, hab. session 20.30.40.60.80.60.6-0.6-0.70.6-0.70.7-0.7-0.60.7-0.7-0.7-0.7-0.70.70.70.60.70.5
Novel to familiar place preference ratio0.60.81.6-1.1-1.0-1.01.00.8-0.80.9-0.70.90.8-0.90.61.00.90.9-1.0-0.7-0.6-1.3-1.2
Novelty place preference0.60.71.4-1.0-0.9-0.90.90.7-0.80.8-0.70.80.7-0.90.60.90.90.9-0.9-0.7-0.6-1.2-1.1
Time in novel zone, NPP test0.70.91.6-1.1-1.0-1.01.00.8-0.90.9-0.80.90.8-0.90.71.01.01.0-1.0-0.8-0.7-1.2-1.1
Total zone transitions, NPP test0.10.20.3-0.4-0.4-0.40.40.4-0.60.4-0.40.40.4-0.40.40.40.40.4-0.4-0.4-0.3-0.4-0.5
Total locomotion distance, NPP test0.10.20.4-0.4-0.4-0.40.40.4-0.50.4-0.40.40.4-0.40.40.40.40.4-0.4-0.4-0.3-0.4-0.6
Locomotion velocity, NPP test0.10.10.4-0.4-0.3-0.40.40.3-0.40.3-0.30.30.3-0.30.30.30.30.3-0.3-0.3-0.3-0.4-0.7
Intraocular pressure0.00.00.10.20.20.1-0.1-0.10.0-0.10.1-0.0-0.10.1-0.1-0.1-0.0-0.00.00.00.10.2-0.2
Delta distance traveled before/after self-admin1.92.02.61.61.51.4-1.4-1.41.4-1.41.4-1.4-1.41.4-1.3-1.4-1.4-1.41.41.41.41.21.6
Delta ambulatory time before/after self-admin0.30.50.80.80.80.7-0.7-0.70.7-0.70.7-0.7-0.70.7-0.6-0.7-0.7-0.70.70.70.70.60.9
Parametrial fat weight0.10.10.2-0.4-0.3-0.30.30.4-0.20.3-0.40.40.4-0.30.30.30.40.4-0.4-0.5-0.4-0.4-0.3
Pavlov. Cond. lever latency0.40.60.70.80.60.6-0.6-0.70.7-0.80.7-0.8-0.70.8-0.7-0.8-0.8-0.80.80.70.80.80.8
Pavlov. Cond. magazine entry latency0.10.10.3-0.2-0.2-0.30.30.2-0.20.2-0.20.30.2-0.30.20.30.30.3-0.3-0.2-0.3-0.2-0.5
Pavlov. Cond. change in total contacts0.60.70.80.90.90.9-0.9-0.80.9-0.80.8-0.8-0.90.8-0.9-0.8-0.8-0.80.70.80.80.70.4
Pavlov. Cond. index score0.20.30.5-0.5-0.4-0.50.50.5-0.50.5-0.50.50.5-0.50.50.50.50.5-0.6-0.5-0.6-0.5-0.7
Pavlov. Cond. latency score0.00.00.1-0.2-0.1-0.10.10.2-0.20.2-0.20.20.2-0.20.20.20.20.2-0.2-0.2-0.3-0.1-0.3
Pavlov. Cond. lever contacts0.30.30.5-0.6-0.5-0.50.50.5-0.50.6-0.50.60.5-0.60.50.60.60.6-0.6-0.5-0.7-0.6-0.7
Pavlov. Cond. magazine entry number0.00.00.20.0-0.00.0-0.0-0.00.0-0.10.0-0.1-0.00.1-0.0-0.1-0.1-0.10.10.00.2-0.00.4
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.3-0.4-0.30.30.3-0.40.3-0.30.30.3-0.30.30.30.30.3-0.3-0.3-0.2-0.4-0.3
Pavlov. Cond. lever-magazine prob. diff.0.20.30.6-0.5-0.5-0.50.50.5-0.50.5-0.50.60.5-0.60.50.60.60.6-0.6-0.5-0.6-0.5-0.8
Pavlov. Cond. response bias0.81.01.8-1.1-0.9-0.90.90.9-0.91.0-0.91.00.9-1.00.91.01.01.0-1.0-0.9-1.1-1.0-1.3
Pavlov. Cond. lever latency0.00.00.10.10.10.3-0.3-0.10.2-0.10.2-0.1-0.10.1-0.1-0.1-0.1-0.10.10.20.10.00.3
Pavlov. Cond. magazine entry latency0.10.11.0-0.2-0.2-0.20.20.1-0.00.1-0.10.10.0-0.2-0.00.20.20.2-0.3-0.10.0-0.4-1.0
Pavlov. Cond. change in total contacts0.10.20.30.40.20.2-0.2-0.50.5-0.50.4-0.5-0.50.5-0.6-0.4-0.4-0.40.40.50.60.40.0
Pavlov. Cond. index score0.00.00.20.1-0.1-0.10.1-0.20.2-0.10.1-0.1-0.20.1-0.2-0.1-0.1-0.10.00.10.30.0-0.5
Pavlov. Cond. latency score0.00.10.10.20.10.1-0.1-0.30.3-0.20.3-0.2-0.30.2-0.3-0.2-0.2-0.20.20.30.40.2-0.3
Pavlov. Cond. lever contacts0.10.10.3-0.3-0.3-0.40.40.3-0.30.3-0.40.30.3-0.30.20.30.30.3-0.3-0.3-0.2-0.3-0.5
Pavlov. Cond. magazine entry number0.30.30.6-0.6-0.5-0.50.50.7-0.70.6-0.60.60.7-0.60.70.50.50.5-0.5-0.6-0.8-0.50.2
Pavlov. Cond. intertrial magazine entries0.00.00.2-0.1-0.0-0.10.10.1-0.10.1-0.10.10.1-0.10.10.00.00.0-0.0-0.0-0.1-0.10.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.4-0.1-0.2-0.20.20.0-0.00.1-0.10.10.0-0.1-0.10.10.10.1-0.1-0.00.1-0.2-0.6
Pavlov. Cond. response bias0.00.00.20.00.0-0.10.1-0.10.1-0.0-0.0-0.0-0.10.0-0.1-0.00.0-0.0-0.00.00.1-0.0-0.5
Time in closed arm before self-admin0.61.11.6-1.2-1.3-1.11.11.0-1.11.0-1.01.01.0-1.00.91.11.01.0-1.0-1.0-0.9-1.0-1.1
Time in closed arm after self-admin0.70.81.01.00.90.8-0.8-0.90.8-0.90.9-0.9-0.90.9-1.0-0.9-0.9-0.90.90.90.91.00.9
Time in open arm before self-admin0.91.01.81.21.31.1-1.1-1.01.1-1.01.0-1.0-1.01.0-0.8-1.0-1.0-1.01.00.90.81.01.0
Time in open arm after self-admin0.10.20.30.40.40.5-0.5-0.40.5-0.40.4-0.4-0.40.4-0.2-0.4-0.4-0.40.40.30.30.20.6
Bone: periosteal estimation0.20.50.7-0.7-0.5-0.60.60.7-0.70.7-0.70.70.7-0.70.80.70.70.7-0.7-0.8-0.6-0.7-0.8
Bone: periosteal perimeter0.20.40.5-0.6-0.5-0.60.60.7-0.70.7-0.70.70.6-0.70.70.60.70.7-0.7-0.7-0.6-0.6-0.7
Bone: post-yield work0.61.01.41.10.90.8-0.8-1.01.0-1.01.0-1.0-1.01.0-1.1-1.0-1.0-1.01.01.01.20.91.0
Progressive ratio test 1 active lever presses1.83.23.7-1.9-1.8-1.81.81.8-1.81.8-1.81.81.8-1.81.81.81.81.8-1.8-1.8-1.8-1.8-1.5
Progressive ratio test 1 breakpoint1.62.83.3-1.8-1.7-1.71.71.7-1.71.7-1.71.71.7-1.71.61.71.71.7-1.7-1.7-1.6-1.7-1.4
Progressive ratio test 1 inactive lever presses0.71.82.2-1.5-1.4-1.41.41.4-1.41.4-1.41.41.4-1.41.31.41.31.4-1.3-1.4-1.3-1.3-1.1
Progressive ratio test 2 active lever presses1.82.53.0-1.7-1.6-1.61.61.6-1.61.6-1.61.61.6-1.61.71.61.61.6-1.6-1.7-1.7-1.5-1.3
Progressive ratio test 2 breakpoint2.22.83.4-1.8-1.7-1.71.71.7-1.71.7-1.71.71.7-1.71.81.71.71.7-1.7-1.7-1.8-1.6-1.4
Progressive ratio test 2 inactive lever presses0.10.20.2-0.4-0.4-0.40.40.4-0.40.4-0.40.40.4-0.40.50.40.40.4-0.4-0.5-0.5-0.3-0.2
Incentive Sensitization - Responses0.51.51.8-1.3-1.2-1.21.21.3-1.21.2-1.21.21.2-1.21.31.21.21.2-1.2-1.3-1.3-1.1-1.1
Incentive Sensitization - Breakpoint0.61.31.6-1.3-1.1-1.11.11.2-1.11.2-1.11.21.2-1.21.21.11.11.2-1.1-1.2-1.2-1.1-1.1
Sum of active levers in priming session hrs 5-60.30.30.40.50.60.5-0.5-0.50.5-0.50.5-0.5-0.50.5-0.4-0.5-0.5-0.50.50.50.50.40.6
Progressive ratio0.61.82.11.41.51.4-1.4-1.31.2-1.31.4-1.3-1.31.3-1.2-1.3-1.3-1.31.31.41.11.21.4
Food seeking constrained by brief footshock5.16.47.12.72.42.4-2.4-2.62.6-2.62.5-2.6-2.62.5-2.5-2.5-2.5-2.52.52.52.62.52.3
Seeking ratio, punishment vs. effort0.30.71.30.90.60.7-0.7-0.91.0-0.90.8-0.9-0.90.9-0.9-0.8-0.8-0.80.80.81.10.80.7
Retroperitoneal fat weight0.00.10.2-0.3-0.1-0.10.10.3-0.30.3-0.40.30.3-0.30.40.30.30.3-0.3-0.4-0.4-0.3-0.3
Reaction time number correct2.27.89.3-3.0-3.0-3.03.02.8-2.82.8-2.72.82.8-2.82.72.82.82.8-2.7-2.7-2.8-2.7-2.2
Reaction time mean minus median0.00.10.20.40.40.4-0.4-0.30.3-0.30.3-0.3-0.40.3-0.4-0.3-0.3-0.30.20.30.50.2-0.1
Reaction time mean minus median AUC0.00.20.7-0.4-0.4-0.40.40.4-0.40.4-0.40.40.4-0.40.30.50.50.5-0.5-0.4-0.2-0.5-0.9
Reaction time num false alarms3.66.17.2-2.7-2.5-2.52.52.4-2.32.4-2.42.42.4-2.52.42.52.52.5-2.5-2.4-2.5-2.5-2.7
Reaction time num false alarms AUC2.35.26.1-2.5-2.3-2.32.32.3-2.12.3-2.22.32.2-2.32.32.32.32.3-2.3-2.2-2.3-2.2-2.4
Reaction time trials correct on left2.27.89.3-3.0-3.0-3.03.02.8-2.82.8-2.72.82.8-2.82.72.82.82.8-2.7-2.7-2.8-2.7-2.2
Reaction time trials on left2.37.79.3-3.0-3.0-2.92.92.8-2.82.8-2.72.82.8-2.82.72.82.82.8-2.7-2.7-2.7-2.7-2.2
Reaction time mean0.81.82.41.31.41.4-1.4-1.41.4-1.31.4-1.3-1.41.3-1.4-1.3-1.3-1.31.21.31.51.00.6
Reaction time mean AUC0.51.31.71.11.21.3-1.3-1.21.3-1.11.2-1.2-1.21.1-1.2-1.1-1.1-1.11.11.21.30.90.5
Median of all reaction times1.42.22.71.51.61.6-1.6-1.51.6-1.51.5-1.5-1.61.5-1.5-1.4-1.4-1.41.41.51.61.20.8
Reaction time omissions0.00.00.2-0.00.10.2-0.2-0.0-0.10.00.00.0-0.0-0.0-0.10.10.10.1-0.10.00.1-0.2-0.4
Reaction time false alarm rate0.10.10.5-0.4-0.3-0.30.30.4-0.30.4-0.40.40.3-0.40.40.40.40.4-0.4-0.4-0.4-0.4-0.7
Reaction time premature initiation rate0.40.60.70.80.80.8-0.8-0.80.8-0.80.9-0.8-0.80.8-0.8-0.8-0.7-0.70.70.80.80.60.7
Reaction time premature initiations0.10.40.7-0.8-0.8-0.70.70.6-0.60.7-0.50.60.6-0.70.60.70.70.7-0.7-0.6-0.6-0.7-0.5
Std. dev. reaction times0.10.30.40.60.60.7-0.7-0.60.5-0.50.5-0.5-0.60.5-0.6-0.5-0.5-0.50.50.50.70.50.1
Reaction time trials completed2.37.79.3-3.0-3.0-2.92.92.8-2.82.8-2.72.82.8-2.82.72.82.82.8-2.7-2.7-2.7-2.7-2.2
Reaction time trials AUC2.79.411.3-3.4-3.3-3.23.23.1-3.13.1-3.03.03.0-3.13.03.13.03.0-3.0-3.0-3.0-3.0-2.5
Run reversals in cocaine runway, females0.20.30.40.60.50.5-0.5-0.50.5-0.50.4-0.5-0.50.5-0.5-0.5-0.5-0.50.50.50.60.50.4
Run reversals in cocaine runway, males0.40.40.5-0.7-0.5-0.50.50.7-0.70.7-0.70.70.7-0.70.70.70.70.7-0.7-0.7-0.7-0.7-0.7
Latency to leave start box in cocaine runway0.10.10.3-0.4-0.5-0.40.40.3-0.30.3-0.20.30.3-0.30.10.40.30.3-0.4-0.1-0.1-0.6-0.2
Latency to leave start box in cocaine runway, F0.70.81.1-1.0-0.9-0.90.90.9-1.01.0-0.90.90.9-1.00.71.01.00.9-1.0-0.8-0.8-1.0-0.6
Latency to leave start box in cocaine runway, M0.10.10.20.20.10.2-0.2-0.40.4-0.30.4-0.3-0.40.3-0.4-0.3-0.3-0.30.30.40.40.10.1
Std. dev. time between licks in bursts0.00.00.1-0.3-0.3-0.30.30.10.00.10.00.10.0-0.1-0.10.20.10.1-0.10.0-0.1-0.4-0.3
Total sessions with >9 infusions3.74.65.4-2.3-2.2-2.22.22.2-2.22.2-2.22.22.2-2.12.22.12.12.1-2.1-2.1-2.1-2.1-1.8
Short access day 1 total inactive lever presses0.30.60.7-0.8-0.7-0.70.70.8-0.70.8-0.70.80.8-0.80.80.80.80.8-0.8-0.8-0.8-0.7-0.7
Short access day 10 total inactive lever presses0.21.41.71.31.21.2-1.2-1.21.2-1.21.2-1.2-1.21.2-1.2-1.2-1.2-1.21.21.11.21.21.0
Short access day 1 total infusions1.32.53.0-1.7-1.6-1.61.61.6-1.61.6-1.61.61.6-1.61.71.61.61.6-1.6-1.6-1.6-1.6-1.3
Short access day 10 total infusions2.84.65.4-2.3-2.2-2.22.22.2-2.22.2-2.22.22.1-2.22.12.12.12.1-2.1-2.1-2.1-2.1-1.9
Short access total infusions1.92.73.3-1.8-1.7-1.71.71.7-1.71.7-1.71.71.7-1.71.71.61.61.7-1.6-1.7-1.7-1.6-1.3
Short access day 1 locomotion2.44.04.7-2.2-2.0-2.02.02.0-2.02.0-2.02.02.0-2.02.02.02.02.0-2.0-2.0-2.0-2.0-1.7
Short access day 10 total locomotion0.00.00.2-0.1-0.1-0.10.10.1-0.10.1-0.10.10.1-0.10.00.10.10.1-0.1-0.00.0-0.1-0.5
Short access total locomotion0.60.91.0-1.0-1.0-1.01.01.0-1.01.0-1.01.00.9-1.00.91.01.01.0-1.0-0.9-0.9-1.0-1.0
One hour access (0.3 mA shock)0.00.00.1-0.2-0.2-0.20.20.2-0.20.2-0.20.20.2-0.20.10.20.20.2-0.2-0.2-0.1-0.2-0.1
Compulsive drug intake0.20.30.6-0.5-0.6-0.60.60.5-0.60.5-0.60.50.5-0.50.40.60.60.5-0.6-0.5-0.4-0.6-0.7
One hour access (shock baseline)0.51.31.5-1.2-1.1-1.11.11.1-1.11.1-1.11.11.1-1.11.11.11.11.1-1.1-1.1-1.1-1.1-0.9
Social response proportion1.01.32.3-1.3-1.1-1.21.21.0-1.01.1-1.01.11.0-1.11.01.21.21.2-1.2-1.0-0.9-1.4-1.5
Social responses0.81.11.5-1.2-0.9-0.90.91.0-1.01.0-1.11.11.0-1.11.01.11.11.1-1.1-1.0-1.0-1.2-1.2
Social time2.84.45.22.32.02.0-2.0-2.12.1-2.12.1-2.1-2.12.1-2.3-2.1-2.1-2.12.12.12.22.01.9
Soleus weight0.10.40.5-0.7-0.7-0.70.70.6-0.50.6-0.50.60.6-0.60.60.60.60.6-0.6-0.5-0.5-0.7-0.6
Bone: stiffness0.71.31.6-1.2-1.1-1.11.11.2-1.21.2-1.21.11.2-1.11.21.11.11.1-1.1-1.2-1.0-0.9-1.0
Tibialis anterior weight3.311.213.6-3.7-3.3-3.23.23.3-3.23.4-3.23.43.3-3.43.43.43.43.4-3.4-3.3-3.3-3.5-3.3
Time to tail flick, vehicle, before self-admin2.53.03.5-1.9-1.7-1.71.71.8-1.71.8-1.81.81.8-1.71.81.71.71.7-1.7-1.8-1.8-1.8-1.5
Time to tail flick, vehicle, after self-admin0.00.00.0-0.2-0.2-0.10.10.1-0.10.1-0.20.10.1-0.10.10.10.10.1-0.1-0.2-0.2-0.0-0.0
Time to tail flick, test, before self-admin0.40.50.60.70.70.8-0.8-0.70.8-0.70.7-0.7-0.70.7-0.6-0.7-0.7-0.70.70.70.60.60.6
Time to tail flick, test, after self-admin0.20.20.40.50.50.5-0.5-0.40.5-0.50.4-0.5-0.40.5-0.4-0.5-0.5-0.50.50.40.30.60.6
Delta time to tail flick, vehicle, before/after SA0.10.10.20.30.30.3-0.3-0.30.3-0.30.3-0.3-0.30.3-0.4-0.3-0.3-0.30.30.30.30.40.2
Delta time to tail flick, test, before/after SA0.70.91.0-1.0-0.9-1.01.00.9-1.00.9-1.00.90.9-0.90.80.90.90.9-0.9-1.0-0.9-0.8-0.7
Tibia length0.20.61.3-0.7-0.6-0.80.80.7-0.90.8-0.80.80.7-0.80.60.80.80.8-0.8-0.8-0.6-0.7-1.1
Ambulatory time before self-admin0.00.00.0-0.0-0.20.0-0.0-0.00.0-0.00.0-0.0-0.00.0-0.1-0.0-0.0-0.00.00.00.10.1-0.2
Ambulatory time after self-admin0.30.50.50.70.60.7-0.7-0.70.7-0.70.7-0.7-0.70.7-0.7-0.7-0.7-0.70.70.70.70.60.6
Bone: tissue strength0.80.91.11.00.90.8-0.8-0.90.9-0.90.9-0.9-0.90.9-1.0-0.9-0.9-0.90.90.91.00.90.8
Total heroin consumption0.00.00.00.10.10.1-0.1-0.10.1-0.10.1-0.1-0.10.1-0.1-0.1-0.1-0.10.10.10.10.10.2
Bone: trabecular number0.00.10.20.10.00.0-0.0-0.30.4-0.30.3-0.3-0.30.2-0.4-0.2-0.2-0.20.20.40.3-0.0-0.1
Bone: trabecular spacing0.00.00.1-0.0-0.00.0-0.00.2-0.20.2-0.20.20.3-0.20.40.20.20.2-0.2-0.3-0.40.1-0.1
Bone: trabecular thickness1.31.82.4-1.5-1.5-1.51.51.3-1.31.3-1.31.31.3-1.31.11.31.31.3-1.3-1.3-1.2-1.5-1.5
Bone: trabecular tissue density0.30.50.6-0.7-0.6-0.60.60.7-0.80.7-0.70.70.7-0.70.60.70.70.7-0.7-0.8-0.7-0.7-0.8
Water consumed over 24 hours0.10.10.30.30.10.3-0.3-0.40.5-0.40.5-0.4-0.50.4-0.5-0.3-0.3-0.30.30.50.50.1-0.1
Number of responses in last shaping day2.63.43.8-1.9-1.9-1.91.91.8-1.91.8-1.91.81.8-1.81.91.81.81.8-1.8-1.8-1.8-1.8-1.8