Hub : Genes

Poteml2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Poteml2 0.12 0.06 4.9e-08 0.04 0.06 0.06 0.06 7.9e-05 1.2e-07 1.6e-07 1.7e-07
2 NAcc gene expression Poteml2 0.14 0.07 0.0e+00 0.11 0.12 0.12 0.12 7.9e-16 4.2e-18 3.3e-18 2.5e-18
3 PL gene expression Poteml2 0.16 0.08 1.3e-12 0.11 0.11 0.11 0.11 1.0e-11 2.5e-12 1.9e-12 2.7e-12
4 Brain alternative TSS XM_063275936.1 0.04 0.03 9.2e-03 0.03 0.01 0.02 0.03 1.0e-03 1.6e-02 2.2e-03 1.7e-03
5 pVTA alternative TSS XM_063275936.1 0.04 0.03 1.0e-03 0.05 0.04 0.04 0.05 7.5e-05 1.5e-04 2.6e-04 1.3e-04
6 Brain gene expression Poteml2 0.1 0.06 4.3e-07 0.03 0.07 0.05 0.06 6.5e-04 4.9e-07 1.6e-05 1.0e-06
7 BLA gene expression Poteml2 0.2 0.1 2.4e-08 0.13 0.14 0.13 0.14 3.0e-07 5.8e-08 1.4e-07 8.3e-08
8 Adipose gene expression Poteml2 0.12 0.06 2.3e-14 0.11 0.11 0.12 0.12 8.2e-12 9.4e-12 4.8e-13 4.0e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density3.05.210.8-1.13.33.01.11.12.93.00.9
Area under the delay curve0.20.20.9-0.90.2-0.6-0.2-0.2-0.20.10.1
BMI with tail0.93.18.5-2.90.3-0.3-2.3-2.3-0.9-0.4-2.1
BMI without tail1.64.812.5-3.50.40.0-2.9-2.9-0.9-0.5-2.8
Body weight1.87.727.5-5.22.41.4-3.0-3.00.41.1-2.6
Weight adjusted by age0.81.12.9-1.1-0.10.5-1.5-1.5-0.4-0.5-1.7
Bone surface1.22.25.2-1.32.31.80.20.21.81.90.3
Bone volume1.62.96.7-1.62.62.30.10.12.02.10.1
Breakpoint value in progressive ratio session0.91.11.7-0.1-1.3-1.3-0.8-0.8-1.3-1.3-0.8
Number of licking bursts0.30.41.4-0.30.6-0.30.60.60.50.81.2
Context. condit. distance diff. score1.11.32.01.00.80.81.41.41.21.11.4
Locomotion velocity, session 10.90.91.6-0.7-1.0-1.3-0.8-0.8-1.2-1.0-0.7
Locomotion distance, session 10.30.40.80.40.30.10.90.90.40.50.9
Locomotion velocity, session 21.72.03.8-2.0-0.6-1.0-1.7-1.7-1.3-1.0-1.5
Locomotion distance, session 20.30.40.70.7-0.2-0.40.90.90.00.00.8
Locomotion velocity, session 30.70.81.61.3-1.3-1.20.30.3-0.8-0.90.4
Locomotion distance, session 31.51.62.10.91.01.41.41.41.41.31.1
Stereotopy head waving bouts, day 31.92.36.01.60.0-0.72.02.00.60.72.4
Stereotopy head waving duration, day 30.70.82.50.8-0.1-0.91.11.10.10.31.6
Locomotion velocity, session 70.60.61.50.9-1.2-1.0-0.1-0.1-0.8-0.9-0.0
Locomotion distance, session 70.20.30.60.7-0.6-0.70.40.4-0.3-0.30.5
Stereotopy head waving bouts, day 70.50.61.00.60.50.51.01.00.80.71.0
Stereotopy head waving duration, day 70.00.00.10.4-0.1-0.00.30.30.0-0.00.3
Locomotion velocity, session 81.01.22.71.2-1.5-1.70.40.4-1.1-1.10.6
Locomotion distance, session 80.30.51.10.50.50.20.90.90.60.71.0
Degree of sensitization distance1.11.22.7-0.0-1.3-1.7-0.8-0.8-1.3-1.3-0.4
Degree of sensitization stereotypy0.50.61.20.10.91.10.50.51.00.90.4
Conditioned locomotion0.50.60.90.50.60.71.01.00.70.70.9
Cocaine response after cond. corrected0.60.71.31.10.30.61.11.10.80.60.8
Cocaine response after cond. not corrected0.40.51.91.4-0.5-0.20.80.80.0-0.20.7
Cocaine response before conditioning1.41.73.5-0.1-1.7-1.9-1.0-1.0-1.7-1.6-0.6
Saline control response0.10.10.3-0.00.40.60.00.00.40.3-0.1
Bone: connectivity density2.53.98.6-1.52.92.70.50.52.42.50.3
Bone: cortical apparent density0.20.30.7-0.4-0.4-0.1-0.7-0.7-0.6-0.6-0.8
Bone: cortical area1.42.24.6-2.11.61.9-1.3-1.30.80.9-1.5
Bone: cortical porosity0.40.40.6-0.6-0.5-0.8-0.8-0.8-0.8-0.6-0.5
Bone: cortical porosity0.10.20.4-0.6-0.1-0.5-0.5-0.5-0.4-0.2-0.2
Bone: cortical thickness1.21.94.6-1.32.02.2-0.1-0.11.61.6-0.4
Bone: cortical thickness4.95.89.00.52.82.72.12.13.03.02.1
Bone: cortical tissue density0.20.30.6-0.3-0.5-0.2-0.6-0.6-0.6-0.6-0.8
Condit. Reinf. active minus inactive responses1.71.93.7-0.31.91.11.01.01.71.91.3
Condit. Reinf. active-inactive response ratio3.23.45.70.32.41.91.51.52.42.41.5
Condit. Reinf. active responses0.91.22.6-0.81.60.70.70.71.31.50.9
Condit. Reinf. inactive responses0.70.82.2-1.5-0.2-0.3-1.0-1.0-0.7-0.5-1.1
Incentive salience index mean0.60.82.0-1.21.40.20.30.30.91.20.7
Condit. Reinf. lever presses0.40.63.3-1.80.7-0.6-0.5-0.5-0.10.40.0
Condit. Reinf. active minus inactive responses0.10.20.50.7-0.20.50.50.50.2-0.00.2
Condit. Reinf. active-inactive response ratio0.10.10.2-0.30.10.5-0.2-0.20.00.0-0.3
Condit. Reinf. active responses0.30.41.31.1-0.9-0.40.50.5-0.5-0.70.2
Condit. Reinf. inactive responses1.21.53.71.5-1.9-1.40.20.2-1.3-1.6-0.1
Condit. Reinf. lever presses1.01.32.3-0.2-1.5-1.2-0.9-0.9-1.5-1.5-0.9
Condit. Reinf. lever reinforcers received0.30.41.00.7-1.0-0.50.10.1-0.7-0.9-0.3
Conditioned reinforcement - actives0.40.71.8-1.30.60.7-1.0-1.00.10.2-1.2
Conditioned reinforcement - inactives1.42.14.9-2.21.41.7-1.3-1.30.70.8-1.6
Conditioned locomotion0.40.51.4-1.20.50.4-0.8-0.80.10.1-0.9
Patch foraging indifference point 0 sec1.12.14.6-2.2-0.6-1.6-1.7-1.7-1.3-0.8-1.1
Patch foraging indifference point AUC1.52.24.8-0.4-1.7-2.2-1.1-1.1-1.9-1.7-0.8
Delay disc. indifference point, 0s delay0.70.82.60.6-1.0-1.60.60.6-0.7-0.51.1
Delay disc. indifference point, 16s delay0.20.21.0-0.2-0.4-1.0-0.1-0.1-0.5-0.40.3
Delay disc. indifference point, 2s delay0.20.20.80.10.0-0.50.60.60.10.30.9
Delay disc. indifference point, 24s delay0.40.41.7-1.30.2-0.5-0.7-0.7-0.4-0.1-0.4
Delay disc. indifference point, 4s delay0.20.20.9-0.90.2-0.3-0.4-0.4-0.20.1-0.2
Delay disc. indifference point, 8s delay0.50.51.6-1.3-0.2-0.9-0.8-0.8-0.7-0.3-0.4
Indifference point function ln k0.81.43.2-0.91.81.70.20.21.41.5-0.0
Indifference point function log k0.81.43.2-0.91.81.70.20.21.41.5-0.0
Patch foraging total patch changes 0 sec1.52.87.2-2.7-0.4-1.5-2.0-2.0-1.4-0.8-1.4
Patch foraging total patch changes 12 sec1.31.63.4-0.9-1.3-1.8-1.2-1.2-1.6-1.3-0.7
Patch foraging total patch changes 18 sec1.52.35.00.3-2.1-2.2-0.9-0.9-1.9-1.9-0.5
Patch foraging total patch changes 24 sec0.20.41.2-0.3-0.7-1.1-0.3-0.3-0.7-0.6-0.0
Patch foraging total patch changes 6 sec2.03.15.6-1.6-1.4-2.4-1.8-1.8-2.0-1.5-1.1
Patch foraging time to switch 0 sec0.10.20.80.9-0.7-0.20.20.2-0.3-0.50.2
Patch foraging water rate 0 sec0.20.52.6-1.60.5-0.5-0.6-0.6-0.10.3-0.3
Patch foraging water rate 12 sec0.30.71.6-1.31.30.6-0.1-0.10.81.0-0.1
Patch foraging water rate 18 sec0.30.41.1-1.11.00.20.10.10.60.90.3
Patch foraging water rate 24 sec1.21.74.0-1.52.01.20.20.21.41.80.4
Patch foraging water rate 6 sec0.40.62.0-1.41.00.5-0.5-0.50.50.7-0.4
Seeking ratio, delayed vs. immediate footshock0.20.30.60.1-0.8-0.8-0.2-0.2-0.7-0.6-0.0
Distance traveled before self-admin0.71.01.4-1.1-0.6-0.9-1.2-1.2-1.0-0.8-1.0
Distance traveled after self-admin0.40.50.9-0.9-0.1-0.3-0.9-0.9-0.5-0.4-0.9
Extensor digitorum longus weight0.10.30.7-0.8-0.2-0.6-0.7-0.7-0.5-0.3-0.3
Bone: elastic displacement0.20.20.30.10.50.30.30.30.60.60.5
Bone: elastic work0.50.61.8-1.30.90.7-0.8-0.80.40.5-0.7
Bone: endosteal estimation0.30.71.7-1.3-0.1-0.5-1.1-1.1-0.6-0.4-0.8
Bone: endosteal perimeter0.30.61.4-1.20.30.4-1.0-1.0-0.2-0.1-1.1
Epididymis fat weight1.03.49.5-3.10.60.6-2.3-2.3-0.4-0.1-2.4
Delta time in closed arm before/after self-admin0.20.20.6-0.7-0.2-0.8-0.3-0.3-0.4-0.20.1
Delta time in open arm before/after self-admin0.10.10.70.8-0.40.00.30.3-0.1-0.30.1
Diff in mean of infusions in LGA sessions3.03.65.0-1.1-1.9-1.9-2.0-2.0-2.2-2.1-1.9
Delay discount exponential model param0.20.21.11.0-0.40.30.30.30.0-0.2-0.0
Extinction: sum of active levers before priming0.10.10.2-0.4-0.2-0.3-0.2-0.2-0.2-0.1-0.1
Active lever presses in extinction session 60.10.10.20.4-0.4-0.2-0.0-0.0-0.3-0.4-0.1
Bone: final force1.52.49.0-3.01.20.7-1.7-1.70.10.5-1.5
Bone: final moment1.42.28.2-2.91.30.8-1.6-1.60.20.6-1.4
Food consumed during 24 hour testing period0.20.30.60.30.40.00.60.60.50.50.8
Glucose1.22.02.8-1.3-1.0-1.0-1.7-1.7-1.5-1.3-1.6
Heart weight2.13.25.50.12.32.31.31.32.32.21.1
Delay discount hyperbolic model param0.20.21.01.0-0.30.40.20.20.1-0.2-0.1
Intermittent access intake day 1-15 change0.40.82.40.11.11.60.40.41.10.9-0.0
Intermittent access intake escalation0.40.92.40.21.11.60.50.51.21.00.1
Intermittent access intake escalation 20.40.51.0-0.90.81.0-0.5-0.50.40.4-0.8
Intermitt. access day 1 inactive lever presses0.00.20.70.3-0.10.80.10.10.1-0.2-0.7
Intermitt. access day 15 inactive lever presses0.20.40.90.90.20.80.80.80.50.20.1
Intermitt. access escalation Index0.20.30.70.10.4-0.20.60.60.40.50.9
Intermittent access day 1 total infusions0.50.81.1-0.8-0.8-1.0-0.9-0.9-1.0-0.9-0.9
Intermittent access day 15 total infusions0.20.41.0-0.40.81.00.10.10.70.7-0.2
Intermittent access terminal intake (last 3 days)0.20.20.4-0.60.60.6-0.0-0.00.40.4-0.3
Intermittent access total infusions0.30.40.9-0.90.10.2-0.8-0.8-0.2-0.2-0.9
Intermittent access day 1 locomotion1.21.62.6-1.5-0.6-0.7-1.6-1.6-1.1-0.9-1.5
Intermittent access day 15 total locomotion0.10.20.4-0.60.50.4-0.4-0.40.20.2-0.4
Intermittent access total locomotion0.70.81.7-1.3-0.1-0.1-1.2-1.2-0.5-0.4-1.3
Intermittent access standard deviation0.10.20.5-0.60.50.7-0.2-0.20.30.3-0.5
Left kidney weight0.63.04.4-1.7-1.2-1.3-2.1-2.1-1.8-1.5-1.9
Right kidney weight1.77.613.2-3.1-1.2-1.3-3.6-3.6-2.3-2.0-3.5
Cocaine induced anxiety1.42.13.1-0.3-1.7-1.5-1.2-1.2-1.7-1.8-1.4
Post-drug Anxiety0.60.61.40.2-1.2-1.0-0.4-0.4-1.0-1.1-0.5
Baseline Anxiety0.91.01.90.80.70.61.21.21.01.01.4
Tail length0.41.75.4-2.30.60.5-1.6-1.6-0.10.1-1.4
Length with tail0.72.99.5-3.11.41.2-1.8-1.80.30.7-1.7
Length without tail0.61.94.3-1.32.12.1-0.1-0.11.51.6-0.2
Times rat made contact with spout0.10.10.3-0.50.4-0.5-0.0-0.00.20.50.5
Lifetime Intake0.50.61.6-1.30.30.3-1.0-1.0-0.1-0.1-1.1
Liver weight, left0.00.10.30.6-0.30.20.20.2-0.1-0.3-0.1
Liver weight, right1.62.75.8-2.2-0.20.1-2.2-2.2-0.9-0.8-2.4
Locomotor activity0.50.81.9-1.31.40.6-0.1-0.10.91.20.3
Locomotor testing distance0.91.63.4-0.51.81.40.80.81.61.70.9
Locomotor testing rearing0.20.41.1-0.91.00.6-0.0-0.00.60.80.1
Locomotion in novel chamber0.10.10.8-0.90.30.0-0.1-0.10.00.30.0
Locomotion in novel chamber post-restriction1.72.86.1-1.12.52.00.80.82.02.20.9
Fecal boli incidents, locomotor time 10.40.61.1-1.1-0.3-0.7-0.9-0.9-0.7-0.5-0.8
Change in fecal boli incidents, locomotor task0.70.61.31.1-1.2-1.00.50.5-0.6-0.70.6
Time >=10cm from walls, locomotor time 11.11.21.9-0.2-1.3-1.3-0.9-0.9-1.4-1.4-0.8
Bouts of movement, locomotor time 10.30.30.4-0.5-0.3-0.5-0.6-0.6-0.6-0.5-0.6
Total resting periods, locomotor time 10.10.10.1-0.2-0.2-0.4-0.3-0.3-0.4-0.4-0.3
Rest time, locomotor task time 10.10.10.20.10.0-0.50.30.3-0.10.00.5
Distance moved, locomotor task time 10.20.30.70.5-0.8-0.5-0.1-0.1-0.6-0.7-0.2
Vertical activity count, locomotor time 10.00.00.1-0.00.00.4-0.2-0.20.10.0-0.3
Time >=10cm from walls, locomotor time 21.01.53.21.80.20.51.61.60.90.61.5
Bouts of movement, locomotor time 20.20.41.10.7-0.9-1.00.10.1-0.6-0.60.2
Total resting periods, locomotor time 20.30.51.30.5-0.9-1.1-0.1-0.1-0.8-0.80.0
Rest time, locomotor task time 20.10.10.3-0.5-0.2-0.4-0.3-0.3-0.4-0.2-0.1
Distance moved, locomotor task time 20.10.20.90.9-0.20.40.30.30.2-0.1-0.0
Vertical activity count, locomotor time 20.71.01.41.20.81.11.01.01.10.90.8
Light reinforcement 10.20.40.8-0.5-0.7-0.9-0.5-0.5-0.8-0.7-0.5
Light reinforcement 21.01.52.5-0.4-1.4-1.6-1.0-1.0-1.6-1.5-0.9
Bone: marrow area0.30.61.6-1.30.0-0.5-1.0-1.0-0.5-0.3-0.7
Bone: maximum diameter0.40.81.7-1.30.91.1-0.8-0.80.50.6-0.8
Bone: maximum force1.62.810.1-3.21.50.9-1.7-1.70.30.8-1.5
Bone: maximum moment1.32.38.1-2.81.51.0-1.5-1.50.40.8-1.3
Mean time between licks in bursts0.61.44.8-2.20.80.6-1.4-1.4-0.00.2-1.3
Mean num. licks in bursts0.10.10.40.00.40.6-0.2-0.20.40.3-0.4
Cd content in liver3.53.97.4-0.32.72.61.21.22.62.61.1
Co content in liver0.10.10.30.6-0.2-0.40.40.40.10.00.5
Cu content in liver1.11.33.01.20.50.01.41.41.00.91.7
Fe content in liver0.20.31.31.1-0.6-0.20.20.2-0.2-0.40.2
K content in liver1.00.91.71.3-0.8-0.91.11.1-0.3-0.31.2
Mg content in liver0.30.30.60.7-0.2-0.10.80.80.10.00.6
Mn content in liver0.10.10.30.30.20.50.20.20.30.2-0.1
Na content in liver0.20.20.50.5-0.7-0.70.20.2-0.5-0.50.3
Rb content in liver1.41.62.90.41.41.71.11.11.61.40.9
Se content in liver0.40.51.61.3-0.40.20.90.90.2-0.00.6
Sr content in liver0.40.41.1-0.5-0.00.6-0.8-0.8-0.2-0.3-1.0
Zn content in liver0.30.30.70.3-0.8-0.4-0.3-0.3-0.6-0.8-0.5
Bone: minimum diameter1.22.15.3-2.30.50.5-1.8-1.8-0.4-0.2-2.0
Time in familiar zone, hab. session 10.60.61.3-1.10.10.1-1.1-1.1-0.3-0.3-1.0
Time in novel zone, hab. session 12.62.63.40.81.51.21.91.91.81.81.8
Total zone transitions, hab. session 10.10.10.4-0.6-0.0-0.4-0.2-0.2-0.3-0.1-0.1
Total locomotion distance, hab. session 10.10.20.4-0.50.60.00.40.40.40.60.4
Locomotion velocity, hab. session 10.10.10.4-0.5-0.1-0.6-0.1-0.1-0.3-0.1-0.0
Time in familiar zone, hab. session 20.20.20.6-0.40.30.8-0.4-0.40.10.1-0.6
Time in novel zone, hab. session 20.40.40.70.70.30.20.80.80.60.50.8
Total zone transitions, hab. session 20.10.10.40.6-0.10.20.50.50.1-0.00.2
Total locomotion distance, hab. session 21.11.41.90.61.11.21.31.31.41.31.0
Locomotion velocity, hab. session 20.60.81.10.50.80.91.11.11.01.00.9
Novel to familiar place preference ratio0.10.10.4-0.60.10.1-0.4-0.4-0.1-0.1-0.6
Novelty place preference0.10.10.2-0.40.0-0.0-0.3-0.3-0.1-0.1-0.4
Time in novel zone, NPP test0.00.00.0-0.20.10.0-0.0-0.0-0.0-0.0-0.2
Total zone transitions, NPP test0.40.51.20.30.4-0.01.11.10.50.61.1
Total locomotion distance, NPP test1.31.72.90.41.20.51.61.61.31.41.7
Locomotion velocity, NPP test0.50.71.50.10.7-0.01.11.10.70.91.2
Intraocular pressure0.30.51.4-0.20.91.20.10.10.90.8-0.0
Delta distance traveled before/after self-admin0.10.20.4-0.50.00.3-0.5-0.5-0.1-0.2-0.7
Delta ambulatory time before/after self-admin0.00.00.10.2-0.10.3-0.0-0.0-0.0-0.1-0.2
Parametrial fat weight2.14.810.0-3.2-0.2-0.1-2.9-2.9-1.4-1.1-3.0
Pavlov. Cond. lever latency0.20.20.90.9-0.10.90.30.30.3-0.0-0.2
Pavlov. Cond. magazine entry latency0.10.20.8-0.90.3-0.3-0.4-0.4-0.10.1-0.2
Pavlov. Cond. change in total contacts0.30.31.5-1.20.5-0.8-0.1-0.1-0.10.40.4
Pavlov. Cond. index score0.20.31.0-1.00.0-0.9-0.5-0.5-0.4-0.10.0
Pavlov. Cond. latency score0.30.31.4-0.8-0.1-1.2-0.3-0.3-0.5-0.20.3
Pavlov. Cond. lever contacts0.40.51.3-1.2-0.2-1.1-0.7-0.7-0.7-0.4-0.3
Pavlov. Cond. magazine entry number0.20.31.01.0-0.20.30.60.60.30.10.4
Pavlov. Cond. intertrial magazine entries3.84.57.00.62.42.12.02.02.62.62.0
Pavlov. Cond. lever-magazine prob. diff.0.20.30.8-0.9-0.1-0.9-0.4-0.4-0.5-0.2-0.1
Pavlov. Cond. response bias0.20.21.3-1.10.4-0.4-0.4-0.4-0.10.2-0.1
Pavlov. Cond. lever latency2.02.73.90.71.81.81.61.62.01.91.5
Pavlov. Cond. magazine entry latency1.41.72.4-0.4-1.4-1.4-1.4-1.4-1.5-1.5-1.1
Pavlov. Cond. change in total contacts1.11.83.2-0.3-1.6-1.8-1.2-1.2-1.7-1.5-0.8
Pavlov. Cond. index score2.02.74.0-0.7-1.8-1.9-1.6-1.6-2.0-1.9-1.3
Pavlov. Cond. latency score1.62.23.5-0.3-1.7-1.9-1.3-1.3-1.8-1.7-1.0
Pavlov. Cond. lever contacts1.72.43.6-0.5-1.8-1.8-1.4-1.4-1.9-1.8-1.2
Pavlov. Cond. magazine entry number2.43.03.91.11.61.71.91.92.01.81.7
Pavlov. Cond. intertrial magazine entries0.40.60.80.20.90.80.80.80.90.90.5
Pavlov. Cond. lever-magazine prob. diff.2.02.74.0-0.8-1.7-1.9-1.6-1.6-2.0-1.8-1.4
Pavlov. Cond. response bias2.33.14.4-0.9-1.8-1.8-1.8-1.8-2.1-2.0-1.7
Time in closed arm before self-admin1.82.44.6-1.5-0.7-0.7-1.9-1.9-1.4-1.3-2.2
Time in closed arm after self-admin0.60.71.4-1.2-0.1-0.1-1.1-1.1-0.5-0.4-1.2
Time in open arm before self-admin0.20.20.50.10.30.20.50.50.50.60.7
Time in open arm after self-admin1.21.31.70.90.91.11.31.31.21.11.2
Bone: periosteal estimation0.71.44.0-2.01.00.9-1.3-1.30.20.4-1.3
Bone: periosteal perimeter0.91.52.8-1.71.11.5-1.2-1.20.50.5-1.5
Bone: post-yield work0.20.30.5-0.10.70.30.50.50.60.70.6
Progressive ratio test 1 active lever presses1.21.52.2-1.5-0.7-1.1-1.5-1.5-1.2-0.9-1.2
Progressive ratio test 1 breakpoint1.01.22.0-1.4-0.6-1.0-1.3-1.3-1.1-0.8-1.1
Progressive ratio test 1 inactive lever presses0.40.51.8-0.8-0.00.5-0.8-0.8-0.3-0.4-1.3
Progressive ratio test 2 active lever presses0.40.50.9-0.9-0.3-0.3-0.9-0.9-0.5-0.4-0.9
Progressive ratio test 2 breakpoint0.30.40.7-0.8-0.2-0.3-0.8-0.8-0.4-0.3-0.8
Progressive ratio test 2 inactive lever presses0.10.20.5-0.70.50.4-0.2-0.20.20.3-0.3
Incentive Sensitization - Responses0.00.00.1-0.4-0.1-0.2-0.2-0.2-0.1-0.0-0.1
Incentive Sensitization - Breakpoint0.00.00.0-0.2-0.1-0.2-0.1-0.1-0.1-0.0-0.1
Sum of active levers in priming session hrs 5-63.43.24.41.71.31.32.12.11.81.62.1
Progressive ratio0.30.50.80.90.40.70.80.80.70.50.8
Food seeking constrained by brief footshock4.35.37.71.12.32.52.32.32.82.62.1
Seeking ratio, punishment vs. effort1.01.42.4-0.21.61.21.01.01.51.60.9
Retroperitoneal fat weight1.04.314.7-3.81.61.3-2.2-2.20.20.7-2.2
Reaction time number correct0.10.30.8-0.90.40.3-0.5-0.50.10.2-0.6
Reaction time mean minus median0.41.12.20.0-1.3-1.5-0.7-0.7-1.4-1.3-0.5
Reaction time mean minus median AUC0.40.92.00.1-1.3-1.4-0.6-0.6-1.3-1.2-0.5
Reaction time num false alarms0.20.30.60.3-0.7-0.7-0.3-0.3-0.6-0.7-0.4
Reaction time num false alarms AUC0.20.40.80.6-0.9-0.8-0.1-0.1-0.7-0.8-0.2
Reaction time trials correct on left0.10.30.8-0.90.40.3-0.5-0.50.10.2-0.6
Reaction time trials on left0.20.31.0-1.00.30.3-0.7-0.7-0.00.1-0.7
Reaction time mean1.01.62.3-0.4-1.2-0.8-1.4-1.4-1.4-1.5-1.5
Reaction time mean AUC1.42.33.7-0.1-1.8-1.4-1.4-1.4-1.9-1.9-1.5
Median of all reaction times0.71.01.8-0.3-0.9-0.3-1.1-1.1-1.0-1.2-1.4
Reaction time omissions2.43.54.5-1.4-1.6-1.6-2.1-2.1-2.1-1.9-1.9
Reaction time false alarm rate0.10.10.40.6-0.4-0.50.30.3-0.2-0.20.3
Reaction time premature initiation rate0.20.30.90.30.1-0.30.70.70.20.40.9
Reaction time premature initiations0.00.00.2-0.50.1-0.30.00.0-0.10.10.2
Std. dev. reaction times1.01.82.5-0.6-1.3-1.2-1.4-1.4-1.6-1.5-1.4
Reaction time trials completed0.20.31.0-1.00.30.3-0.7-0.7-0.00.1-0.7
Reaction time trials AUC0.20.41.3-1.20.40.3-0.7-0.7-0.00.1-0.8
Run reversals in cocaine runway, females1.01.02.7-1.60.50.4-1.3-1.3-0.2-0.0-1.3
Run reversals in cocaine runway, males0.50.51.41.2-1.0-0.80.40.4-0.5-0.60.4
Latency to leave start box in cocaine runway0.20.20.9-1.00.1-0.2-0.5-0.5-0.2-0.0-0.4
Latency to leave start box in cocaine runway, F0.20.21.2-1.10.60.2-0.3-0.30.20.4-0.2
Latency to leave start box in cocaine runway, M0.30.30.50.1-0.7-0.7-0.3-0.3-0.6-0.7-0.3
Std. dev. time between licks in bursts0.70.93.0-1.71.30.8-0.5-0.50.70.9-0.4
Total sessions with >9 infusions1.01.32.7-1.50.20.3-1.7-1.7-0.3-0.2-1.4
Short access day 1 total inactive lever presses0.71.02.1-1.01.41.4-0.5-0.51.01.0-0.5
Short access day 10 total inactive lever presses0.61.53.91.4-2.0-1.30.40.4-1.4-1.6-0.2
Short access day 1 total infusions1.41.94.8-2.21.61.5-1.1-1.10.81.0-1.1
Short access day 10 total infusions0.60.81.8-1.21.40.9-0.2-0.20.91.1-0.1
Short access total infusions0.70.82.5-1.60.50.2-1.2-1.2-0.10.1-0.9
Short access day 1 locomotion1.62.04.4-2.11.41.4-1.6-1.60.60.7-1.5
Short access day 10 total locomotion0.61.12.2-1.21.51.5-0.3-0.31.01.1-0.6
Short access total locomotion0.70.91.8-1.31.21.0-0.8-0.80.70.7-0.7
One hour access (0.3 mA shock)0.80.92.1-0.61.50.90.30.31.21.40.7
Compulsive drug intake0.40.51.31.00.10.00.80.80.40.31.1
One hour access (shock baseline)0.40.61.8-1.30.60.6-0.8-0.80.20.3-0.9
Social response proportion3.13.57.0-0.42.62.21.21.22.42.51.2
Social responses2.53.26.1-0.42.51.81.31.32.32.41.4
Social time0.81.01.60.80.90.71.11.11.11.01.3
Soleus weight0.72.25.7-2.4-0.2-0.9-2.0-2.0-1.1-0.6-1.3
Bone: stiffness0.81.44.7-2.20.80.5-1.3-1.3-0.00.2-1.3
Tibialis anterior weight0.10.41.4-1.20.60.3-0.7-0.70.10.3-0.4
Time to tail flick, vehicle, before self-admin0.10.10.50.30.20.70.20.20.50.40.1
Time to tail flick, vehicle, after self-admin0.50.71.4-0.0-0.9-0.3-1.0-1.0-0.8-1.0-1.2
Time to tail flick, test, before self-admin0.00.00.1-0.10.10.3-0.2-0.20.10.1-0.2
Time to tail flick, test, after self-admin0.60.62.11.5-0.4-0.11.01.00.2-0.00.9
Delta time to tail flick, vehicle, before/after SA0.10.10.20.0-0.3-0.3-0.3-0.3-0.4-0.4-0.4
Delta time to tail flick, test, before/after SA0.20.20.40.30.40.20.60.60.40.40.6
Tibia length0.10.31.1-1.00.70.1-0.4-0.40.20.5-0.2
Ambulatory time before self-admin1.42.12.8-1.6-0.9-1.2-1.7-1.7-1.4-1.2-1.6
Ambulatory time after self-admin1.11.32.3-1.5-0.4-0.4-1.4-1.4-0.9-0.8-1.5
Bone: tissue strength1.71.72.4-0.6-1.3-1.1-1.3-1.3-1.5-1.5-1.5
Total heroin consumption1.41.72.6-0.5-1.4-1.6-1.1-1.1-1.6-1.5-1.1
Bone: trabecular number2.44.09.1-1.93.02.60.20.22.32.50.2
Bone: trabecular spacing0.91.22.40.5-1.5-1.5-0.4-0.4-1.4-1.4-0.5
Bone: trabecular thickness1.72.14.8-1.02.21.80.50.51.82.00.7
Bone: trabecular tissue density0.71.01.7-0.3-1.2-1.2-0.8-0.8-1.3-1.2-0.8
Water consumed over 24 hours0.20.30.6-0.80.8-0.2-0.0-0.00.40.70.5
Number of responses in last shaping day1.01.12.8-0.81.71.10.30.31.31.50.7