Hub : Genes

Polr3h

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Polr3h 0.12 0.06 1.7e-14 0.09 0.09 0.1 0.09 1.0e-09 1.2e-09 7.8e-11 2.0e-10
2 PL gene expression Polr3h 0.08 0.04 6.3e-08 0.05 0.06 0.05 0.06 5.1e-06 9.4e-07 1.7e-06 1.2e-06
3 pVTA intron excision ratio chr7_115319588_115319855 0.07 0.06 7.6e-05 0.04 0.04 0.02 0.04 1.7e-04 2.0e-04 5.5e-03 3.0e-04
4 pVTA gene expression Polr3h 0.12 0.05 2.1e-14 0.17 0.19 0.17 0.17 5.1e-14 7.2e-15 7.4e-14 6.5e-14
5 Brain intron excision ratio chr7_115319588_115319855 0.03 0.02 3.4e-03 0.02 0.02 0 0.02 6.7e-03 4.1e-03 1.4e-01 1.0e-02
6 IC gene expression Polr3h 0.07 0.05 2.2e-03 0.07 0.05 0.05 0.06 7.6e-04 4.8e-03 4.1e-03 2.4e-03
7 pVTA intron excision ratio chr7_115326028_115329409 0.05 0.03 3.1e-05 0.06 0.06 0.05 0.06 9.2e-06 2.9e-05 1.0e-04 3.3e-05
8 Brain gene expression Polr3h 0.11 0.05 1.5e-12 0.13 0.13 0.12 0.13 4.7e-12 9.1e-12 5.7e-11 5.2e-12
9 Liver gene expression Polr3h 0.07 0.05 5.9e-06 0.01 0.02 0.02 0.02 1.9e-02 1.0e-03 2.6e-03 2.8e-03
10 RMTg gene expression Polr3h 0.18 0.09 1.8e-04 0.06 0.12 0.07 0.13 1.3e-02 4.8e-04 7.1e-03 2.2e-04
11 IC intron excision ratio chr7_115319588_115319855 0.11 0.07 1.2e-03 0.05 0.06 0.06 0.06 2.8e-03 1.6e-03 1.3e-03 1.2e-03
12 NAcc gene expression Polr3h 0.06 0.04 1.1e-07 0.04 0.06 0.05 0.05 1.8e-06 9.4e-09 9.4e-08 2.7e-08
13 NAcc intron excision ratio chr7_115326028_115329409 0.03 0.02 1.8e-04 0.02 0.02 0.02 0.01 7.3e-04 7.6e-04 1.9e-04 2.0e-03
14 BLA intron excision ratio chr7_115329548_115332009 0.06 0.04 2.0e-03 0.03 0.03 0.04 0.03 1.3e-02 1.2e-02 2.8e-03 9.8e-03
15 BLA intron excision ratio chr7_115319588_115319855 0.09 0.06 2.0e-03 0.04 0.02 0.02 0.02 2.5e-03 4.5e-02 3.2e-02 4.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.30.41.3-0.90.3-0.70.7-0.90.60.70.8-0.70.4-1.10.30.60.1-0.1
Area under the delay curve0.10.10.3-0.60.6-0.20.5-0.50.50.40.2-0.20.3-0.4-0.30.1-0.40.4
BMI with tail0.82.75.01.6-2.22.0-1.91.9-1.9-1.7-1.71.5-2.00.5-1.6-0.8-1.01.0
BMI without tail0.10.20.80.2-0.60.3-0.20.10.10.3-0.0-0.20.2-0.60.20.80.9-0.9
Body weight1.04.37.22.5-2.62.3-2.52.2-2.7-2.4-2.22.3-2.01.5-1.7-1.6-0.60.6
Weight adjusted by age0.30.41.50.70.2-0.0-0.1-0.10.40.20.30.20.90.80.60.61.2-1.2
Bone surface0.40.71.8-0.50.4-0.60.5-1.10.60.70.9-0.31.3-0.40.9-0.01.3-1.4
Bone volume0.10.10.4-0.30.0-0.20.2-0.50.30.30.5-0.20.5-0.30.40.10.6-0.6
Breakpoint value in progressive ratio session0.10.10.6-0.3-0.3-0.00.0-0.1-0.10.20.00.0-0.5-0.5-0.30.1-0.80.8
Number of licking bursts0.40.61.3-1.00.9-0.90.9-1.10.90.90.7-0.51.1-0.60.50.50.5-0.5
Context. condit. distance diff. score5.76.911.53.4-2.53.1-3.03.3-2.9-2.9-3.02.7-2.43.1-1.7-2.1-0.60.6
Locomotion velocity, session 10.50.52.20.20.3-0.2-0.0-0.40.30.1-0.10.41.30.70.6-0.61.5-1.5
Locomotion distance, session 12.53.26.4-1.82.2-2.01.9-2.11.91.81.8-1.42.5-0.61.61.01.7-1.7
Locomotion velocity, session 20.20.20.60.8-0.50.6-0.50.4-0.3-0.4-0.30.50.00.4-0.0-0.60.5-0.5
Locomotion distance, session 22.33.16.7-2.61.6-2.02.0-2.52.02.01.9-1.51.6-2.30.70.90.1-0.1
Locomotion velocity, session 30.40.41.80.90.00.4-0.40.5-0.4-0.4-0.30.40.51.30.5-0.41.1-1.1
Locomotion distance, session 31.41.53.5-0.81.9-1.31.2-1.01.00.91.0-0.91.80.61.40.71.5-1.5
Stereotopy head waving bouts, day 30.60.71.61.1-1.21.1-1.10.7-0.8-0.9-0.81.0-0.70.3-0.6-0.9-0.10.1
Stereotopy head waving duration, day 32.73.26.42.5-2.52.4-2.32.0-1.8-1.9-1.91.9-1.51.2-1.2-1.4-0.20.2
Locomotion velocity, session 70.20.20.70.60.00.3-0.30.5-0.6-0.6-0.40.3-0.10.9-0.10.10.2-0.2
Locomotion distance, session 70.20.21.0-0.40.5-0.20.3-0.1-0.3-0.20.0-0.1-0.4-0.0-0.60.2-1.01.0
Stereotopy head waving bouts, day 72.22.55.62.4-1.31.5-1.71.6-1.4-1.5-1.51.5-0.12.30.2-1.21.7-1.7
Stereotopy head waving duration, day 71.82.25.42.3-1.41.4-1.71.9-1.4-1.5-1.41.2-0.52.10.3-0.91.4-1.4
Locomotion velocity, session 81.82.14.21.7-1.91.9-1.81.2-1.4-1.3-1.61.9-0.91.0-1.2-2.1-0.30.3
Locomotion distance, session 80.60.91.61.3-0.91.3-1.11.3-0.9-0.9-1.10.9-0.61.2-0.5-0.70.0-0.0
Degree of sensitization distance3.23.37.21.2-2.11.9-1.61.7-1.8-1.6-1.61.3-2.7-0.0-2.1-1.0-2.42.4
Degree of sensitization stereotypy1.71.84.32.0-1.01.2-1.51.4-1.2-1.3-1.31.2-0.12.10.3-1.01.5-1.5
Conditioned locomotion0.50.61.41.1-0.61.0-0.91.2-0.8-0.8-0.90.6-0.51.0-0.3-0.00.2-0.1
Cocaine response after cond. corrected0.10.10.30.5-0.10.1-0.30.3-0.4-0.3-0.20.2-0.10.50.10.00.3-0.3
Cocaine response after cond. not corrected0.10.10.20.5-0.20.2-0.20.3-0.1-0.00.0-0.00.10.30.30.30.5-0.5
Cocaine response before conditioning0.20.20.6-0.30.20.00.4-0.20.80.70.7-0.70.4-0.50.50.60.2-0.2
Saline control response0.20.30.80.7-0.10.7-0.30.50.20.10.10.10.40.70.7-0.20.9-0.9
Bone: connectivity density0.10.10.5-0.50.1-0.40.3-0.60.20.30.5-0.20.2-0.70.10.10.1-0.1
Bone: cortical apparent density0.81.11.7-1.31.3-1.21.3-1.21.21.11.1-1.11.1-0.80.70.90.4-0.4
Bone: cortical area1.21.83.81.6-1.91.7-1.71.4-1.3-1.3-1.51.5-1.30.6-1.3-1.0-0.60.6
Bone: cortical porosity0.30.30.70.8-0.70.7-0.60.8-0.6-0.5-0.50.2-0.70.2-0.2-0.0-0.20.2
Bone: cortical porosity1.11.22.51.6-1.51.5-1.41.5-1.3-1.1-1.11.0-1.10.8-0.5-0.7-0.10.1
Bone: cortical thickness0.60.92.80.2-1.10.8-0.60.3-0.5-0.5-0.70.7-1.2-0.7-1.6-0.6-1.71.7
Bone: cortical thickness0.91.02.90.1-1.10.8-0.70.2-0.4-0.6-0.80.9-1.1-0.6-1.7-0.9-1.71.7
Bone: cortical tissue density0.71.01.6-1.31.3-1.21.2-1.21.11.11.0-1.01.1-0.70.70.80.4-0.4
Condit. Reinf. active minus inactive responses0.20.20.6-0.70.1-0.30.4-0.60.50.40.2-0.20.2-0.7-0.20.0-0.40.4
Condit. Reinf. active-inactive response ratio0.30.30.60.6-0.50.6-0.60.5-0.3-0.5-0.70.6-0.40.6-0.4-0.8-0.10.1
Condit. Reinf. active responses1.11.42.8-1.61.0-1.11.3-1.41.71.51.2-1.30.8-1.60.51.0-0.20.2
Condit. Reinf. inactive responses2.42.95.3-2.21.6-1.61.9-1.72.32.11.9-2.01.3-1.81.11.80.1-0.1
Incentive salience index mean0.40.51.5-1.10.4-0.50.7-0.90.90.70.6-0.60.2-1.2-0.20.4-0.60.6
Condit. Reinf. lever presses0.71.02.2-1.30.8-0.81.1-1.11.31.11.0-1.10.6-1.50.31.0-0.20.2
Condit. Reinf. active minus inactive responses0.30.41.2-0.6-0.30.0-0.1-0.5-0.0-0.1-0.30.6-0.3-0.6-1.0-1.0-1.11.1
Condit. Reinf. active-inactive response ratio0.50.51.5-0.4-0.6-0.0-0.3-0.4-0.4-0.4-0.50.7-0.7-0.6-1.1-1.1-1.21.2
Condit. Reinf. active responses0.50.72.10.4-0.90.8-0.80.3-0.6-0.8-0.91.2-0.60.3-1.2-1.5-0.80.7
Condit. Reinf. inactive responses0.70.91.81.1-0.81.4-1.00.9-0.8-0.9-1.01.2-0.51.0-0.9-1.1-0.20.2
Condit. Reinf. lever presses0.30.41.0-1.00.3-0.60.6-0.90.70.60.7-0.40.3-0.90.1-0.0-0.20.2
Condit. Reinf. lever reinforcers received0.30.51.60.1-0.70.6-0.60.0-0.4-0.5-0.60.9-0.5-0.0-1.0-1.3-0.80.8
Conditioned reinforcement - actives0.50.81.60.7-0.80.9-0.80.7-0.7-1.3-1.21.0-0.90.6-1.2-0.9-0.70.7
Conditioned reinforcement - inactives0.50.72.3-0.6-0.70.3-0.1-0.40.20.5-0.50.3-0.6-1.2-1.4-0.0-1.51.5
Conditioned locomotion1.72.33.90.9-1.91.6-1.51.3-1.4-1.7-1.71.4-1.9-0.2-2.0-1.4-1.41.4
Patch foraging indifference point 0 sec0.40.62.6-1.10.2-0.70.7-1.11.01.00.7-0.80.4-1.60.30.5-0.20.2
Patch foraging indifference point AUC0.30.41.2-0.71.0-0.60.7-1.00.50.50.7-0.11.1-0.00.3-0.00.2-0.2
Delay disc. indifference point, 0s delay0.91.01.91.0-1.21.3-1.11.3-0.8-0.9-1.00.6-1.40.3-0.8-0.6-0.90.9
Delay disc. indifference point, 16s delay0.80.91.8-1.31.3-1.11.2-1.30.81.01.1-0.81.0-0.70.50.70.2-0.2
Delay disc. indifference point, 2s delay0.10.20.6-0.0-0.00.5-0.10.20.1-0.2-0.40.2-0.4-0.1-0.7-0.1-0.80.8
Delay disc. indifference point, 24s delay0.30.31.2-0.30.8-0.80.4-0.70.00.10.10.31.10.30.1-0.10.7-0.7
Delay disc. indifference point, 4s delay0.30.30.9-0.4-0.30.3-0.0-0.40.40.2-0.20.3-0.2-0.7-0.8-0.6-0.90.9
Delay disc. indifference point, 8s delay0.40.51.2-1.01.1-0.71.0-0.90.80.70.7-0.70.7-0.80.10.4-0.10.1
Indifference point function ln k0.50.91.71.3-1.21.1-1.11.3-1.2-1.1-1.10.7-1.10.7-0.4-0.6-0.00.0
Indifference point function log k0.50.91.71.3-1.21.1-1.11.3-1.2-1.1-1.10.7-1.10.7-0.4-0.6-0.00.0
Patch foraging total patch changes 0 sec0.40.82.7-1.20.3-0.80.9-1.21.21.20.8-0.90.5-1.60.40.6-0.20.1
Patch foraging total patch changes 12 sec0.10.10.2-0.3-0.10.00.1-0.40.20.20.20.10.2-0.4-0.1-0.4-0.30.3
Patch foraging total patch changes 18 sec0.20.31.2-0.8-0.1-0.10.3-0.70.60.60.1-0.20.1-1.1-0.3-0.3-0.70.7
Patch foraging total patch changes 24 sec0.20.40.7-0.60.7-0.50.7-0.80.90.80.7-0.50.8-0.40.60.20.2-0.2
Patch foraging total patch changes 6 sec0.40.62.5-1.1-0.0-0.40.5-1.31.01.00.7-0.20.7-1.6-0.0-0.1-0.30.3
Patch foraging time to switch 0 sec0.10.20.70.20.1-0.10.10.40.00.10.2-0.70.1-0.00.60.70.8-0.8
Patch foraging water rate 0 sec0.10.31.1-0.7-0.2-0.30.2-0.80.60.50.40.10.0-1.0-0.1-0.4-0.70.6
Patch foraging water rate 12 sec0.30.71.1-0.90.6-1.10.7-0.91.00.80.6-0.70.9-0.51.00.41.0-1.1
Patch foraging water rate 18 sec1.11.73.2-1.51.1-1.71.3-1.81.41.41.5-1.01.5-1.21.30.80.9-1.0
Patch foraging water rate 24 sec0.10.10.70.0-0.6-0.1-0.3-0.2-0.1-0.2-0.10.4-0.2-0.3-0.1-0.80.2-0.2
Patch foraging water rate 6 sec1.01.42.3-1.11.2-1.31.1-1.31.11.31.2-1.01.5-0.51.50.61.3-1.3
Seeking ratio, delayed vs. immediate footshock2.63.16.0-2.41.9-2.22.2-2.11.81.72.0-2.01.1-2.21.11.50.1-0.1
Distance traveled before self-admin0.40.61.4-0.90.1-0.10.5-0.30.51.10.2-0.6-0.3-1.2-0.70.9-1.21.2
Distance traveled after self-admin0.30.41.7-0.7-0.60.10.1-0.70.60.40.1-0.1-0.0-1.3-0.70.4-0.70.7
Extensor digitorum longus weight0.20.71.2-0.70.5-0.60.7-0.60.90.90.9-1.00.7-0.71.01.10.7-0.7
Bone: elastic displacement0.20.31.30.5-0.10.0-0.30.1-0.2-0.1-0.20.30.50.60.6-0.21.1-1.1
Bone: elastic work1.82.44.51.9-2.11.7-2.01.6-1.7-1.6-1.71.7-1.41.0-1.0-1.5-0.30.3
Bone: endosteal estimation0.61.32.91.7-1.01.2-1.21.1-0.8-0.9-0.70.90.11.50.7-0.81.7-1.7
Bone: endosteal perimeter1.22.66.32.5-1.61.8-1.92.0-1.7-1.7-1.51.4-0.62.10.0-0.71.4-1.4
Epididymis fat weight2.27.511.73.4-2.73.1-3.03.4-3.2-3.2-2.82.6-3.12.4-2.2-1.8-1.61.6
Delta time in closed arm before/after self-admin0.50.51.90.2-0.50.7-0.40.4-0.5-0.2-0.60.6-0.7-0.1-1.1-0.2-1.41.4
Delta time in open arm before/after self-admin0.60.62.0-0.10.6-0.50.3-0.20.8-0.20.3-0.50.70.61.2-0.71.4-1.4
Diff in mean of infusions in LGA sessions0.10.10.50.3-0.40.2-0.3-0.1-0.50.0-0.10.7-0.0-0.0-0.7-0.3-0.40.4
Delay discount exponential model param0.20.20.40.6-0.60.2-0.50.6-0.6-0.4-0.20.2-0.40.40.2-0.20.3-0.3
Extinction: sum of active levers before priming0.80.91.30.9-1.01.0-1.00.9-1.2-1.0-0.91.1-1.10.5-0.9-0.8-0.90.9
Active lever presses in extinction session 60.20.20.40.3-0.50.6-0.50.5-0.3-0.6-0.20.4-0.50.1-0.2-0.4-0.10.1
Bone: final force1.42.23.71.3-1.91.6-1.61.1-1.6-1.5-1.31.6-1.60.3-1.7-1.7-1.41.4
Bone: final moment1.52.44.21.4-2.11.7-1.71.2-1.6-1.5-1.41.8-1.60.3-1.8-1.8-1.31.3
Food consumed during 24 hour testing period1.42.02.81.2-1.71.5-1.51.2-1.5-1.4-1.51.5-1.60.4-1.7-1.2-1.41.4
Glucose0.10.20.8-0.3-0.20.10.2-0.00.50.40.4-0.5-0.2-0.9-0.20.8-0.20.2
Heart weight5.99.117.63.2-4.23.9-3.73.3-2.8-2.8-3.43.1-3.11.4-2.8-2.7-1.51.5
Delay discount hyperbolic model param0.10.10.30.5-0.50.0-0.40.4-0.5-0.4-0.10.1-0.30.30.4-0.00.5-0.5
Intermittent access intake day 1-15 change0.20.31.8-0.60.4-0.60.6-0.40.40.60.5-0.80.3-0.50.31.30.1-0.1
Intermittent access intake escalation0.20.51.9-0.70.6-0.70.7-0.60.60.80.6-0.80.6-0.50.51.40.3-0.3
Intermittent access intake escalation 20.50.61.9-0.60.8-0.80.8-0.50.60.80.7-1.00.6-0.40.71.40.6-0.6
Intermitt. access day 1 inactive lever presses0.41.54.60.0-1.51.0-0.80.5-0.3-0.6-0.80.7-1.8-1.1-1.7-0.8-2.12.1
Intermitt. access day 15 inactive lever presses0.71.55.5-1.0-1.00.6-0.2-0.20.00.6-0.50.3-1.2-1.9-1.8-0.7-2.42.3
Intermitt. access escalation Index0.30.41.7-0.80.2-0.40.4-0.70.81.30.3-0.30.7-1.0-0.00.60.1-0.1
Intermittent access day 1 total infusions0.71.12.40.7-1.11.0-1.00.7-0.6-0.3-1.21.1-1.10.2-1.5-0.5-1.61.6
Intermittent access day 15 total infusions0.10.10.6-0.30.1-0.10.2-0.20.40.6-0.1-0.20.1-0.2-0.20.8-0.40.4
Intermittent access terminal intake (last 3 days)0.10.10.70.10.2-0.00.10.20.00.3-0.2-0.10.00.3-0.10.9-0.20.2
Intermittent access total infusions0.30.30.80.4-0.50.5-0.40.5-0.4-0.0-0.70.4-0.60.2-0.80.4-0.90.9
Intermittent access day 1 locomotion0.40.51.6-0.1-0.70.4-0.30.2-0.1-0.1-0.50.2-1.0-0.8-1.0-0.2-1.31.3
Intermittent access day 15 total locomotion0.10.20.50.4-0.50.3-0.40.4-0.6-0.5-0.50.3-0.70.1-0.6-0.0-0.40.4
Intermittent access total locomotion0.30.41.00.4-0.60.4-0.50.5-0.7-0.6-0.70.4-1.00.2-0.80.1-0.90.9
Intermittent access standard deviation0.40.82.10.6-1.10.9-0.71.1-0.8-0.4-0.90.2-1.5-0.2-1.10.7-1.21.2
Left kidney weight9.242.862.37.5-7.97.9-7.86.9-7.2-7.0-7.27.4-6.04.9-5.7-6.4-2.52.5
Right kidney weight10.949.571.07.6-8.48.2-8.27.4-7.9-7.6-7.77.7-7.14.6-6.6-6.7-3.73.7
Cocaine induced anxiety0.81.12.91.0-0.90.5-0.90.8-1.7-1.3-1.01.2-1.30.6-1.1-0.7-1.01.0
Post-drug Anxiety0.00.10.20.10.2-0.50.1-0.2-0.4-0.1-0.00.20.10.30.10.30.1-0.1
Baseline Anxiety1.82.13.5-1.41.7-1.31.5-1.31.91.61.3-1.51.8-0.41.51.41.3-1.3
Tail length0.72.65.5-0.91.5-1.41.3-1.31.51.61.5-1.42.2-0.32.01.62.3-2.4
Length with tail0.20.71.71.3-0.70.7-0.90.8-1.1-0.9-0.71.0-0.11.3-0.0-0.70.7-0.8
Length without tail1.96.29.72.6-2.72.4-2.72.4-3.1-2.9-2.42.7-2.71.8-2.2-2.6-1.61.6
Times rat made contact with spout0.70.81.60.6-0.91.1-0.80.5-0.9-0.7-0.91.1-0.70.3-1.3-0.9-1.01.0
Lifetime Intake1.01.23.10.5-1.21.0-0.90.7-0.8-0.4-1.31.0-1.3-0.0-1.8-0.2-1.61.7
Liver weight, left1.01.76.71.9-0.41.2-1.21.7-1.2-1.4-1.31.1-0.22.60.0-0.51.1-1.0
Liver weight, right1.93.49.12.9-1.22.1-2.02.6-1.9-2.0-1.71.5-0.93.0-0.3-0.61.1-1.1
Locomotor activity1.62.54.31.9-1.81.6-1.91.8-2.1-1.9-1.71.7-1.31.6-0.7-1.50.1-0.2
Locomotor testing distance0.00.10.1-0.30.3-0.30.3-0.30.10.20.2-0.30.2-0.20.30.20.1-0.1
Locomotor testing rearing1.02.03.21.8-1.41.7-1.61.8-1.6-1.5-1.71.3-1.31.4-1.1-1.0-0.50.5
Locomotion in novel chamber0.60.82.1-0.30.6-0.40.4-0.21.10.50.3-0.90.90.61.31.01.5-1.4
Locomotion in novel chamber post-restriction0.71.11.9-0.91.4-1.11.2-0.80.90.81.1-1.31.0-0.31.21.21.0-1.0
Fecal boli incidents, locomotor time 10.20.30.5-0.60.4-0.40.5-0.70.20.50.7-0.40.7-0.70.30.10.6-0.6
Change in fecal boli incidents, locomotor task0.80.72.01.0-0.40.4-0.80.5-0.9-1.0-1.01.20.11.3-0.3-1.40.7-0.7
Time >=10cm from walls, locomotor time 10.10.10.40.6-0.40.1-0.30.3-0.6-0.5-0.20.4-0.40.3-0.20.0-0.20.2
Bouts of movement, locomotor time 10.60.71.50.7-0.00.3-0.50.8-1.2-1.1-0.60.7-1.10.9-0.5-0.7-1.21.2
Total resting periods, locomotor time 10.60.62.40.40.00.2-0.20.5-1.0-0.9-0.40.4-1.10.3-0.7-0.3-1.51.5
Rest time, locomotor task time 11.11.43.70.4-0.80.9-0.70.9-1.3-1.1-1.00.7-1.7-0.2-1.7-0.5-1.91.9
Distance moved, locomotor task time 10.30.41.51.1-0.60.8-0.70.80.0-0.3-0.50.4-0.11.20.2-0.20.4-0.4
Vertical activity count, locomotor time 10.00.10.30.3-0.1-0.0-0.0-0.10.30.20.1-0.10.30.40.40.20.6-0.6
Time >=10cm from walls, locomotor time 20.10.20.9-0.20.3-0.40.4-0.40.30.40.4-0.50.4-0.50.31.00.3-0.3
Bouts of movement, locomotor time 20.60.93.50.0-0.60.5-0.50.5-0.8-0.8-0.60.4-1.4-0.2-1.1-0.4-1.91.9
Total resting periods, locomotor time 20.50.93.7-0.2-0.50.4-0.40.4-0.7-0.7-0.50.4-1.4-0.5-1.2-0.5-1.91.9
Rest time, locomotor task time 20.10.10.4-0.60.3-0.40.3-0.4-0.2-0.00.1-0.0-0.1-0.6-0.4-0.2-0.50.5
Distance moved, locomotor task time 20.60.71.71.3-0.91.3-1.01.2-0.3-0.6-0.90.6-0.81.1-0.3-0.1-0.40.5
Vertical activity count, locomotor time 20.20.20.70.8-0.50.6-0.50.5-0.2-0.2-0.40.3-0.00.70.10.10.5-0.5
Light reinforcement 10.10.21.00.4-0.30.3-0.30.10.40.1-0.10.20.60.30.4-0.11.0-1.0
Light reinforcement 20.60.81.81.3-0.81.1-1.01.3-1.0-1.0-0.90.7-1.01.1-0.6-0.3-0.50.5
Bone: marrow area0.61.43.01.7-1.11.2-1.31.1-0.9-0.9-0.71.00.11.50.6-0.91.7-1.7
Bone: maximum diameter2.95.49.82.9-3.12.9-2.92.4-2.5-2.4-2.62.6-2.01.6-1.8-1.9-0.40.4
Bone: maximum force2.03.66.31.7-2.52.2-2.11.6-2.0-1.8-1.82.1-2.00.5-2.2-2.0-1.61.5
Bone: maximum moment2.34.07.11.9-2.72.3-2.31.6-2.1-1.9-2.02.3-2.00.6-2.2-2.2-1.51.5
Mean time between licks in bursts0.30.71.8-1.00.8-0.80.9-0.60.90.90.8-1.10.5-0.80.61.40.2-0.2
Mean num. licks in bursts1.42.23.01.7-1.51.7-1.61.7-1.7-1.6-1.51.6-1.61.3-1.3-1.3-0.90.9
Cd content in liver1.11.22.31.0-0.91.1-1.20.9-1.1-1.2-1.41.5-0.71.0-1.3-1.2-0.50.5
Co content in liver0.30.31.0-0.4-0.50.1-0.1-0.4-0.10.1-0.20.4-0.3-1.0-0.9-0.0-1.01.0
Cu content in liver5.97.09.8-3.02.5-3.02.9-3.13.13.13.0-2.72.8-2.52.32.11.5-1.5
Fe content in liver0.40.52.01.0-1.41.0-1.00.6-0.7-0.6-0.50.7-0.60.0-0.2-0.70.3-0.3
K content in liver1.11.01.8-1.21.0-1.01.1-1.31.21.31.2-1.01.2-1.00.80.70.5-0.5
Mg content in liver1.01.02.2-1.40.7-1.01.1-1.31.21.30.9-1.00.8-1.50.30.7-0.20.2
Mn content in liver0.10.10.30.20.20.2-0.00.10.10.1-0.10.10.50.60.2-0.30.5-0.5
Na content in liver2.12.23.1-1.71.4-1.81.6-1.51.81.71.7-1.71.4-1.41.41.30.8-0.8
Rb content in liver0.20.20.70.1-0.60.4-0.4-0.2-0.3-0.1-0.40.7-0.2-0.4-0.8-0.6-0.60.6
Se content in liver0.50.61.1-0.50.9-0.80.8-0.70.70.70.8-0.81.0-0.01.10.41.0-1.0
Sr content in liver2.01.72.8-1.61.5-1.41.6-1.31.71.51.5-1.51.0-1.20.81.4-0.00.0
Zn content in liver0.10.10.5-0.10.2-0.20.2-0.40.30.40.1-0.00.70.00.30.10.6-0.6
Bone: minimum diameter0.30.61.51.2-0.90.9-1.00.9-0.6-0.8-0.80.7-0.31.0-0.0-0.40.7-0.7
Time in familiar zone, hab. session 10.10.10.20.30.10.1-0.10.0-0.3-0.3-0.30.40.30.4-0.3-0.10.2-0.2
Time in novel zone, hab. session 10.30.31.00.8-1.00.8-0.80.9-0.5-0.4-0.50.3-0.60.40.2-0.20.2-0.2
Total zone transitions, hab. session 13.44.88.2-2.32.8-2.42.4-2.42.22.22.3-1.92.9-0.82.11.31.9-1.9
Total locomotion distance, hab. session 12.53.57.5-1.12.2-1.61.6-1.51.71.61.7-1.42.70.22.41.12.7-2.7
Locomotion velocity, hab. session 12.63.67.2-1.52.2-1.81.8-1.82.01.91.8-1.62.7-0.32.21.12.3-2.3
Time in familiar zone, hab. session 20.40.41.30.60.50.0-0.00.60.0-0.1-0.3-0.30.41.20.70.90.9-0.9
Time in novel zone, hab. session 20.20.21.0-0.3-0.60.2-0.2-0.40.00.00.10.5-0.2-0.7-0.5-1.0-0.60.5
Total zone transitions, hab. session 20.91.22.8-1.50.9-0.91.1-1.71.41.31.0-0.71.4-1.30.40.00.4-0.4
Total locomotion distance, hab. session 20.81.11.9-1.40.8-0.91.0-1.41.31.31.0-0.91.2-1.30.60.70.5-0.5
Locomotion velocity, hab. session 21.41.93.1-1.81.2-1.31.4-1.81.71.71.4-1.31.6-1.50.91.00.7-0.7
Novel to familiar place preference ratio1.82.03.81.9-1.51.4-1.71.5-1.7-1.6-1.31.7-0.91.7-0.3-1.30.6-0.6
Novelty place preference2.52.75.42.3-1.71.6-2.01.8-2.0-1.9-1.62.0-1.02.1-0.5-1.40.6-0.6
Time in novel zone, NPP test3.23.46.62.6-1.91.9-2.32.0-2.2-2.2-1.92.2-1.22.3-0.6-1.70.5-0.6
Total zone transitions, NPP test3.04.38.4-2.32.4-2.22.2-2.52.32.32.1-1.62.9-1.11.80.91.7-1.7
Total locomotion distance, NPP test1.52.13.8-1.71.5-1.51.5-1.81.51.61.4-1.22.0-1.01.20.71.2-1.2
Locomotion velocity, NPP test2.33.25.1-2.02.0-1.92.0-2.11.92.01.8-1.72.3-1.21.61.41.4-1.4
Intraocular pressure0.30.41.60.8-0.10.4-0.60.7-0.7-0.9-0.90.7-0.31.3-0.4-0.70.1-0.1
Delta distance traveled before/after self-admin0.50.61.20.8-1.00.7-1.00.3-0.4-1.0-0.81.10.10.8-0.3-0.90.6-0.6
Delta ambulatory time before/after self-admin0.60.71.71.0-1.20.9-1.10.3-0.5-0.9-0.91.30.20.9-0.4-1.00.6-0.6
Parametrial fat weight0.10.31.10.60.50.00.00.6-0.1-0.20.0-0.30.21.10.60.90.8-0.7
Pavlov. Cond. lever latency0.40.51.21.0-0.70.6-0.90.8-0.9-0.8-1.00.8-0.31.1-0.2-0.60.3-0.3
Pavlov. Cond. magazine entry latency0.50.71.4-1.20.8-0.70.9-0.90.70.70.8-0.70.2-1.2-0.20.7-0.90.9
Pavlov. Cond. change in total contacts1.11.13.7-1.60.6-0.81.1-1.41.21.11.0-0.80.4-1.9-0.40.5-1.01.0
Pavlov. Cond. index score0.40.61.6-1.00.4-0.40.7-0.70.50.50.6-0.5-0.2-1.3-0.50.3-1.21.2
Pavlov. Cond. latency score0.40.51.4-0.90.4-0.40.6-0.60.50.50.7-0.5-0.2-1.2-0.40.4-1.11.1
Pavlov. Cond. lever contacts1.31.62.8-1.71.3-1.21.5-1.41.51.31.5-1.40.6-1.60.51.2-0.40.4
Pavlov. Cond. magazine entry number0.60.71.61.3-0.80.7-1.00.9-0.6-0.7-0.80.7-0.11.20.4-0.61.1-1.1
Pavlov. Cond. intertrial magazine entries0.81.02.0-1.40.8-1.21.1-1.41.21.21.1-0.80.9-1.30.70.40.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.50.61.5-1.10.6-0.50.8-0.80.60.60.7-0.6-0.0-1.2-0.40.5-1.11.1
Pavlov. Cond. response bias0.81.02.1-1.40.9-0.81.2-1.10.90.91.0-0.90.2-1.4-0.20.8-1.01.0
Pavlov. Cond. lever latency0.70.93.11.5-0.20.9-0.91.3-1.1-1.1-1.20.9-0.41.8-0.5-0.40.2-0.1
Pavlov. Cond. magazine entry latency2.73.27.9-2.81.3-2.32.0-2.51.71.92.0-1.60.9-2.70.60.7-0.60.6
Pavlov. Cond. change in total contacts0.61.05.3-1.5-0.5-0.60.5-1.30.50.70.7-0.2-0.3-2.3-0.6-0.4-1.31.3
Pavlov. Cond. index score1.52.05.6-2.30.8-1.61.5-2.01.41.51.6-1.20.6-2.40.40.5-0.60.6
Pavlov. Cond. latency score2.02.66.9-2.61.0-1.81.8-2.31.71.81.9-1.40.8-2.60.50.6-0.60.6
Pavlov. Cond. lever contacts0.91.23.4-1.60.4-1.11.1-1.51.31.31.4-1.10.6-1.90.70.40.0-0.0
Pavlov. Cond. magazine entry number1.51.84.82.2-1.01.8-1.52.0-1.2-1.3-1.51.1-0.62.1-0.4-0.20.5-0.5
Pavlov. Cond. intertrial magazine entries2.43.65.61.7-1.92.4-1.91.9-1.6-1.7-2.01.9-2.10.9-2.3-1.6-2.02.0
Pavlov. Cond. lever-magazine prob. diff.1.62.25.7-2.30.9-1.71.6-2.11.51.61.7-1.40.7-2.40.60.6-0.40.4
Pavlov. Cond. response bias0.91.34.1-1.80.4-1.21.1-1.61.21.21.2-1.00.4-2.00.40.3-0.40.3
Time in closed arm before self-admin5.47.013.6-2.02.3-2.72.7-2.42.92.92.9-3.12.6-2.02.63.72.2-2.2
Time in closed arm after self-admin0.20.22.40.40.20.10.20.20.20.20.2-0.40.20.20.11.60.2-0.2
Time in open arm before self-admin0.10.10.40.30.4-0.0-0.00.2-0.4-0.3-0.10.2-0.10.60.2-0.3-0.30.3
Time in open arm after self-admin0.40.51.5-0.10.7-0.60.3-0.30.3-0.30.3-0.30.50.81.2-1.01.1-1.1
Bone: periosteal estimation0.91.94.32.1-1.81.7-1.81.5-1.3-1.4-1.31.4-0.61.4-0.3-1.10.9-0.9
Bone: periosteal perimeter2.74.69.63.1-2.52.6-2.72.6-2.4-2.4-2.42.2-1.52.3-1.0-1.30.5-0.5
Bone: post-yield work0.40.61.60.1-0.90.7-0.60.1-0.6-0.5-0.60.9-0.6-0.5-1.2-0.9-1.01.0
Progressive ratio test 1 active lever presses0.40.51.70.2-0.50.4-0.40.3-0.30.2-0.70.7-0.6-0.2-1.3-0.1-1.31.3
Progressive ratio test 1 breakpoint0.30.41.30.1-0.30.3-0.30.2-0.20.2-0.60.6-0.5-0.1-1.1-0.1-1.21.2
Progressive ratio test 1 inactive lever presses1.52.28.6-0.1-1.41.1-0.70.5-0.2-0.3-1.10.6-2.0-1.1-2.3-0.3-2.92.9
Progressive ratio test 2 active lever presses0.40.41.9-0.0-0.30.3-0.2-0.1-0.20.1-0.60.6-0.5-0.2-1.2-0.1-1.41.4
Progressive ratio test 2 breakpoint0.30.31.5-0.1-0.20.2-0.2-0.1-0.20.2-0.50.6-0.4-0.1-1.1-0.0-1.21.2
Progressive ratio test 2 inactive lever presses0.40.61.6-1.00.5-0.50.7-0.71.01.00.3-0.5-0.0-0.8-0.40.5-1.31.3
Incentive Sensitization - Responses0.10.10.3-0.30.2-0.10.2-0.40.20.4-0.00.10.2-0.0-0.40.3-0.60.6
Incentive Sensitization - Breakpoint0.10.10.6-0.2-0.00.10.1-0.30.10.2-0.20.2-0.0-0.0-0.60.2-0.80.8
Sum of active levers in priming session hrs 5-60.00.00.00.2-0.10.1-0.10.2-0.2-0.1-0.10.0-0.00.10.20.20.2-0.2
Progressive ratio0.10.10.3-0.40.2-0.10.3-0.20.10.30.5-0.4-0.1-0.60.20.3-0.20.2
Food seeking constrained by brief footshock1.31.63.01.1-1.51.3-1.51.2-1.3-1.4-1.71.5-1.30.7-1.5-1.1-0.90.9
Seeking ratio, punishment vs. effort0.60.81.60.8-1.00.9-1.00.8-0.8-1.0-1.31.1-0.90.5-1.2-0.9-0.70.7
Retroperitoneal fat weight3.615.523.74.9-4.14.4-4.54.6-4.7-4.6-4.24.1-3.93.6-3.2-3.2-1.41.4
Reaction time number correct0.81.63.2-0.81.8-1.61.3-1.11.11.01.1-1.11.60.31.70.91.3-1.3
Reaction time mean minus median0.10.20.50.6-0.30.5-0.40.7-0.1-0.2-0.40.1-0.20.50.2-0.10.5-0.5
Reaction time mean minus median AUC0.30.82.11.2-0.81.0-1.01.5-0.9-1.0-1.00.6-0.91.1-0.3-0.3-0.00.0
Reaction time num false alarms0.20.20.90.30.20.00.00.20.50.40.3-0.40.40.41.00.80.7-0.7
Reaction time num false alarms AUC0.20.31.30.10.4-0.10.20.00.70.50.4-0.40.60.51.10.70.7-0.7
Reaction time trials correct on left0.81.63.2-0.81.8-1.61.3-1.11.11.01.1-1.11.60.31.70.91.3-1.3
Reaction time trials on left0.91.73.4-0.81.8-1.61.3-1.11.21.11.2-1.21.60.31.80.91.4-1.4
Reaction time mean0.10.20.4-0.40.2-0.50.3-0.20.60.50.3-0.60.2-0.40.40.40.4-0.4
Reaction time mean AUC0.10.10.3-0.30.3-0.50.3-0.20.50.40.3-0.50.2-0.30.30.30.3-0.3
Median of all reaction times0.30.40.8-0.70.5-0.90.6-0.50.80.70.6-0.80.4-0.70.50.50.4-0.4
Reaction time omissions0.20.30.8-0.20.7-0.40.4-0.20.90.50.3-0.50.70.30.80.30.7-0.6
Reaction time false alarm rate0.10.10.50.5-0.60.7-0.50.60.1-0.1-0.20.1-0.40.20.00.3-0.20.3
Reaction time premature initiation rate0.30.42.6-0.9-0.3-0.40.4-1.00.30.60.7-0.20.1-1.6-0.20.1-0.50.4
Reaction time premature initiations0.30.51.3-0.90.3-0.90.7-1.10.50.70.9-0.50.6-1.20.30.30.0-0.0
Std. dev. reaction times0.20.30.90.8-0.70.7-0.70.9-0.2-0.5-0.80.3-0.40.6-0.0-0.40.4-0.4
Reaction time trials completed0.91.73.4-0.81.8-1.61.3-1.11.21.11.2-1.21.60.31.80.91.4-1.4
Reaction time trials AUC0.71.32.6-0.71.6-1.41.1-0.91.00.91.0-1.01.40.31.60.81.3-1.3
Run reversals in cocaine runway, females0.60.61.3-0.10.8-0.60.6-0.51.00.70.6-0.61.20.10.90.91.1-1.1
Run reversals in cocaine runway, males1.01.03.91.3-0.30.7-1.00.8-0.8-0.8-1.11.40.02.0-0.1-1.50.3-0.3
Latency to leave start box in cocaine runway0.20.20.50.5-0.20.4-0.30.6-0.6-0.7-0.30.2-0.60.3-0.2-0.7-0.20.2
Latency to leave start box in cocaine runway, F0.10.10.3-0.40.4-0.30.4-0.30.10.10.4-0.40.3-0.30.5-0.40.4-0.4
Latency to leave start box in cocaine runway, M1.11.01.71.1-0.91.0-1.01.3-1.2-1.3-0.90.8-1.30.9-0.9-0.7-0.80.8
Std. dev. time between licks in bursts1.21.64.0-1.80.8-1.31.3-1.81.61.51.4-1.11.1-2.00.60.70.2-0.2
Total sessions with >9 infusions4.96.012.21.8-3.02.8-2.51.9-2.3-1.8-2.62.6-2.80.1-3.5-1.5-2.82.8
Short access day 1 total inactive lever presses1.62.05.20.3-2.31.5-1.40.5-0.8-0.9-1.31.4-1.5-1.1-2.1-1.7-1.61.6
Short access day 10 total inactive lever presses0.41.12.00.9-1.11.1-1.11.2-0.8-1.3-1.10.9-1.30.6-0.8-1.4-0.70.7
Short access day 1 total infusions1.92.55.30.8-2.32.0-1.61.1-1.0-0.7-1.71.5-1.8-0.5-2.3-1.3-1.91.9
Short access day 10 total infusions1.31.63.41.0-1.51.4-1.21.2-1.1-0.8-1.31.1-1.7-0.1-1.9-0.2-1.61.6
Short access total infusions3.13.99.61.0-2.52.2-1.81.3-1.4-1.0-2.11.9-2.2-0.6-3.1-1.4-2.62.6
Short access day 1 locomotion0.70.91.90.5-1.41.2-0.80.7-1.0-0.3-0.70.6-1.2-0.6-1.30.1-1.21.2
Short access day 10 total locomotion0.40.72.4-0.7-0.30.20.20.10.40.10.1-0.7-1.2-1.3-0.50.8-1.51.5
Short access total locomotion1.41.63.70.5-1.61.4-1.01.0-0.9-0.8-1.10.7-1.9-0.9-1.8-0.1-1.91.9
One hour access (0.3 mA shock)0.10.10.8-0.40.4-0.40.4-0.10.40.20.0-0.6-0.1-0.2-0.10.9-0.30.3
Compulsive drug intake0.30.42.2-0.80.4-0.50.4-1.10.4-0.30.10.30.7-0.3-0.4-1.50.2-0.2
One hour access (shock baseline)0.20.44.10.10.1-0.20.20.40.10.50.1-0.7-0.30.10.22.0-0.30.3
Social response proportion0.20.20.80.1-0.90.4-0.30.3-0.3-0.2-0.1-0.1-0.7-0.8-0.40.3-0.00.0
Social responses0.20.31.2-0.10.3-0.10.2-0.40.40.30.4-0.20.80.00.60.41.1-1.1
Social time1.52.03.7-1.91.4-1.51.6-1.61.61.71.5-1.61.1-1.60.81.70.0-0.0
Soleus weight0.10.31.0-0.80.1-0.20.4-0.90.60.50.40.10.4-1.0-0.4-0.5-0.40.4
Bone: stiffness1.21.93.91.2-2.01.7-1.51.2-1.3-1.3-1.41.3-1.60.0-1.6-1.2-1.21.2
Tibialis anterior weight0.62.04.3-2.11.4-1.51.6-1.71.61.61.6-1.50.9-1.90.71.4-0.30.3
Time to tail flick, vehicle, before self-admin0.10.10.2-0.0-0.30.2-0.2-0.0-0.00.10.10.20.2-0.20.3-0.50.5-0.5
Time to tail flick, vehicle, after self-admin1.41.95.1-0.81.2-1.30.9-0.91.21.01.0-1.01.90.22.00.92.3-2.3
Time to tail flick, test, before self-admin0.70.72.51.0-0.30.9-0.81.1-1.0-1.0-0.80.8-0.61.6-0.4-0.3-0.40.4
Time to tail flick, test, after self-admin0.50.52.6-0.20.6-0.40.5-0.30.70.90.3-0.60.90.20.51.60.8-0.8
Delta time to tail flick, vehicle, before/after SA0.00.00.1-0.2-0.1-0.1-0.10.00.1-0.0-0.30.0-0.00.10.10.20.1-0.1
Delta time to tail flick, test, before/after SA2.62.74.6-1.41.3-1.61.6-1.72.02.11.6-1.61.8-1.41.31.91.4-1.4
Tibia length0.71.93.51.5-1.51.4-1.61.0-1.6-1.5-1.71.9-1.01.1-1.4-1.8-0.40.4
Ambulatory time before self-admin0.30.41.5-0.80.2-0.10.5-0.40.71.20.1-0.50.1-0.9-0.40.9-0.70.7
Ambulatory time after self-admin0.91.02.3-1.30.4-0.90.9-1.51.41.20.8-0.71.3-1.20.50.90.5-0.5
Bone: tissue strength0.20.20.40.5-0.40.2-0.50.2-0.6-0.5-0.40.6-0.10.5-0.1-0.70.3-0.3
Total heroin consumption0.40.51.30.1-0.70.7-0.50.2-0.4-0.1-0.60.9-0.6-0.1-1.0-0.7-1.11.1
Bone: trabecular number0.10.10.40.10.4-0.30.20.00.0-0.00.1-0.20.30.40.40.50.6-0.6
Bone: trabecular spacing1.41.82.81.1-1.51.3-1.41.1-1.5-1.5-1.51.5-1.50.5-1.7-1.3-1.21.2
Bone: trabecular thickness0.30.30.8-0.60.4-0.50.6-0.30.70.70.7-0.90.2-0.60.70.80.1-0.1
Bone: trabecular tissue density1.82.65.3-2.11.2-1.71.8-1.91.92.02.0-1.81.1-2.31.31.20.2-0.2
Water consumed over 24 hours0.40.51.10.6-0.90.9-0.80.4-0.7-0.6-0.71.0-0.40.2-0.8-1.0-0.50.5
Number of responses in last shaping day1.61.76.3-1.4-0.1-0.10.8-0.81.11.40.8-1.0-0.6-2.5-0.91.5-2.02.0