Hub : Genes

Polr2i

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Polr2i 0.06 0.04 5.6e-04 0.04 0.05 0.05 0.04 3.0e-03 1.5e-03 1.6e-03 2.6e-03
2 Liver gene expression Polr2i 0.06 0.04 5.0e-07 0.04 0.04 0.02 0.04 1.7e-05 2.2e-05 1.2e-03 3.7e-05
3 NAcc gene expression Polr2i 0.07 0.08 5.0e-04 0.02 0.02 0.01 0.01 2.2e-03 4.1e-03 7.1e-03 1.4e-02
4 NAcc mRNA stability Polr2i 0.06 0.04 2.7e-07 0.06 0.06 0.06 0.06 1.7e-07 5.3e-07 2.4e-07 3.1e-07
5 PL mRNA stability Polr2i 0.04 0.04 7.0e-03 0.01 0.01 0.01 0.01 1.3e-02 1.7e-02 1.7e-02 6.1e-02
6 Liver mRNA stability Polr2i 0.05 0.04 9.2e-07 0.04 0.04 0.04 0.04 1.1e-05 2.4e-05 1.1e-05 2.0e-05
7 LHb intron excision ratio chr1_85483874_85484029 0.18 0.12 4.3e-04 0.1 0.03 0.1 -0.01 2.2e-03 7.6e-02 2.1e-03 9.4e-01
8 LHb intron excision ratio chr1_85483951_85484029 0.19 0.12 3.3e-04 0.1 0.02 0.1 -0.01 1.9e-03 1.1e-01 1.9e-03 8.3e-01
9 LHb mRNA stability Polr2i 0.15 0.1 1.6e-03 0.13 0.12 0.13 0.02 6.2e-04 9.2e-04 6.1e-04 1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.71.22.20.6-1.1-1.1-1.0-0.8-1.21.2-1.3-1.5
Area under the delay curve0.30.30.80.9-0.6-0.5-0.6-0.7-0.10.4-0.5-0.3
BMI with tail0.20.71.1-0.80.60.70.91.00.7-0.90.80.9
BMI without tail0.10.10.40.2-0.6-0.6-0.20.0-0.10.4-0.2-0.4
Body weight2.610.914.23.1-3.5-3.5-3.2-3.0-3.83.3-3.0-3.3
Weight adjusted by age0.20.20.6-0.10.1-0.1-0.50.8-0.6-0.00.1-0.6
Bone surface1.73.03.81.7-1.8-1.8-1.6-1.6-1.81.7-2.0-1.6
Bone volume1.62.73.71.5-1.6-1.6-1.5-1.4-1.91.6-1.8-1.7
Breakpoint value in progressive ratio session1.81.94.91.8-1.4-1.2-1.0-2.2-0.71.3-1.5-0.7
Number of licking bursts3.74.45.8-1.82.22.22.12.31.7-2.42.31.8
Context. condit. distance diff. score0.00.10.20.10.20.20.20.2-0.1-0.40.20.4
Locomotion velocity, session 10.50.51.0-1.00.80.81.00.70.5-0.50.40.3
Locomotion distance, session 10.50.60.90.9-0.9-0.9-0.5-0.8-1.00.7-0.8-0.6
Locomotion velocity, session 20.40.51.1-0.80.50.50.80.51.1-0.50.50.8
Locomotion distance, session 21.21.72.7-1.11.21.21.51.21.2-1.51.21.6
Locomotion velocity, session 30.30.30.4-0.60.70.70.50.70.4-0.60.70.5
Locomotion distance, session 32.52.74.82.2-1.6-1.6-1.9-1.9-1.61.3-1.4-0.9
Stereotopy head waving bouts, day 30.50.61.5-1.20.70.70.80.81.1-0.40.50.0
Stereotopy head waving duration, day 31.31.52.9-1.71.21.21.31.31.6-0.91.00.4
Locomotion velocity, session 70.30.30.60.8-0.7-0.7-0.5-0.6-0.70.4-0.6-0.1
Locomotion distance, session 70.10.20.50.4-0.3-0.3-0.3-0.4-0.70.4-0.4-0.1
Stereotopy head waving bouts, day 71.11.31.7-0.91.11.11.21.01.1-1.31.31.3
Stereotopy head waving duration, day 72.42.93.3-1.71.61.61.81.71.8-1.71.81.6
Locomotion velocity, session 83.84.55.7-1.92.12.12.22.12.0-2.42.12.1
Locomotion distance, session 80.81.22.2-0.61.01.01.11.00.7-1.41.11.5
Degree of sensitization distance0.40.41.0-1.00.70.70.90.80.4-0.40.50.3
Degree of sensitization stereotypy1.51.62.3-0.91.21.21.31.21.1-1.51.51.5
Conditioned locomotion0.70.81.3-0.70.90.91.00.51.1-0.90.91.1
Cocaine response after cond. corrected0.10.10.3-0.50.20.20.10.20.50.10.2-0.0
Cocaine response after cond. not corrected0.10.10.2-0.5-0.0-0.0-0.10.10.30.4-0.2-0.3
Cocaine response before conditioning1.41.72.41.2-1.3-1.3-1.3-1.3-1.31.3-1.5-1.3
Saline control response0.00.00.1-0.0-0.2-0.20.1-0.10.00.3-0.10.2
Bone: connectivity density0.40.61.00.5-0.8-0.8-0.7-0.6-0.60.7-1.0-0.8
Bone: cortical apparent density2.33.03.7-1.61.91.91.81.71.3-1.81.71.8
Bone: cortical area1.32.02.21.3-1.4-1.4-1.5-1.4-1.51.5-1.4-1.5
Bone: cortical porosity1.51.62.6-1.01.11.11.01.21.6-1.51.31.4
Bone: cortical porosity2.02.23.1-1.21.31.31.31.41.7-1.81.51.7
Bone: cortical thickness0.30.41.00.5-0.6-0.6-0.7-0.6-0.70.8-0.6-1.0
Bone: cortical thickness0.70.81.3-1.10.90.90.90.90.8-0.70.90.6
Bone: cortical tissue density2.63.54.1-1.72.02.01.91.81.4-2.01.82.0
Condit. Reinf. active minus inactive responses0.20.20.3-0.50.50.50.50.40.6-0.50.40.3
Condit. Reinf. active-inactive response ratio0.20.20.6-0.60.40.40.30.40.8-0.20.3-0.2
Condit. Reinf. active responses2.22.73.1-1.51.61.61.81.51.8-1.71.41.8
Condit. Reinf. inactive responses2.53.05.4-1.31.71.71.91.41.6-1.91.52.3
Incentive salience index mean0.20.20.5-0.30.40.40.40.40.7-0.50.30.4
Condit. Reinf. lever presses0.00.00.10.3-0.2-0.2-0.1-0.20.30.0-0.20.1
Condit. Reinf. active minus inactive responses1.72.12.61.5-1.6-1.6-1.5-1.6-1.01.5-1.4-1.0
Condit. Reinf. active-inactive response ratio0.10.10.2-0.20.20.20.20.20.1-0.10.40.3
Condit. Reinf. active responses3.85.36.32.5-2.5-2.5-2.4-2.4-1.92.3-2.3-1.8
Condit. Reinf. inactive responses4.75.87.22.7-2.7-2.7-2.5-2.5-1.92.2-2.5-1.8
Condit. Reinf. lever presses8.010.911.83.3-3.4-3.4-3.3-3.4-2.93.4-3.3-3.4
Condit. Reinf. lever reinforcers received3.95.46.62.6-2.5-2.5-2.4-2.5-2.12.3-2.3-1.8
Conditioned reinforcement - actives0.20.20.5-0.40.50.70.40.30.2-0.50.60.4
Conditioned reinforcement - inactives0.50.51.51.2-0.9-0.8-0.6-1.0-0.40.1-0.3-0.0
Conditioned locomotion2.32.74.0-1.41.61.81.71.11.6-1.91.62.0
Patch foraging indifference point 0 sec0.10.20.60.4-0.5-0.5-0.8-0.40.00.3-0.3-0.2
Patch foraging indifference point AUC0.20.30.6-0.80.50.30.60.20.7-0.50.60.3
Delay disc. indifference point, 0s delay0.20.20.60.8-0.3-0.20.2-0.5-0.3-0.1-0.10.7
Delay disc. indifference point, 16s delay0.70.71.81.4-0.6-0.6-1.0-1.2-0.20.7-0.9-0.6
Delay disc. indifference point, 2s delay0.80.91.61.3-1.1-1.1-0.8-0.9-1.10.7-0.7-0.3
Delay disc. indifference point, 24s delay2.32.23.21.8-1.6-1.7-1.7-1.1-1.11.3-1.5-1.3
Delay disc. indifference point, 4s delay0.00.10.20.10.10.00.10.10.5-0.30.30.2
Delay disc. indifference point, 8s delay0.20.20.40.5-0.6-0.5-0.6-0.4-0.30.4-0.5-0.6
Indifference point function ln k0.30.40.70.8-0.5-0.4-0.6-0.7-0.70.7-0.8-0.4
Indifference point function log k0.30.40.70.8-0.5-0.4-0.6-0.7-0.70.7-0.8-0.4
Patch foraging total patch changes 0 sec0.20.30.90.6-0.7-0.7-1.0-0.6-0.20.4-0.4-0.3
Patch foraging total patch changes 12 sec0.10.10.30.0-0.1-0.2-0.3-0.40.60.3-0.3-0.2
Patch foraging total patch changes 18 sec0.00.00.1-0.0-0.1-0.1-0.10.2-0.1-0.30.30.2
Patch foraging total patch changes 24 sec0.81.01.41.1-1.0-1.2-1.1-1.0-1.10.7-0.6-0.7
Patch foraging total patch changes 6 sec0.10.10.40.1-0.5-0.7-0.5-0.30.20.20.0-0.1
Patch foraging time to switch 0 sec0.50.71.3-0.90.90.90.90.91.2-0.50.50.7
Patch foraging water rate 0 sec0.61.01.6-1.00.70.70.81.01.0-1.21.31.1
Patch foraging water rate 12 sec0.40.61.70.9-0.7-0.7-0.9-0.7-1.30.30.1-0.8
Patch foraging water rate 18 sec0.10.20.5-0.50.20.20.30.50.5-0.50.70.2
Patch foraging water rate 24 sec0.10.20.50.40.00.00.10.2-0.3-0.60.60.7
Patch foraging water rate 6 sec0.81.22.01.4-1.3-1.3-1.3-0.8-1.30.6-0.6-0.7
Seeking ratio, delayed vs. immediate footshock0.80.92.01.4-0.6-0.7-1.1-1.1-1.20.7-0.9-0.6
Distance traveled before self-admin0.10.10.20.2-0.20.10.3-0.3-0.10.4-0.40.3
Distance traveled after self-admin4.04.55.42.3-2.3-2.2-2.0-1.9-2.12.1-2.2-1.8
Extensor digitorum longus weight0.10.61.2-1.10.80.80.91.00.2-0.50.80.4
Bone: elastic displacement0.00.00.0-0.20.20.2-0.0-0.1-0.10.10.0-0.1
Bone: elastic work1.82.32.61.4-1.5-1.5-1.5-1.6-1.51.6-1.5-1.6
Bone: endosteal estimation1.83.94.62.0-2.1-2.1-1.9-2.0-1.82.0-2.0-1.7
Bone: endosteal perimeter1.53.13.92.0-1.8-1.8-1.7-1.9-1.71.7-1.7-1.3
Epididymis fat weight0.10.10.60.3-0.3-0.2-0.30.1-0.70.2-0.3-0.3
Delta time in closed arm before/after self-admin2.82.73.21.5-1.5-1.7-1.7-1.3-1.71.7-1.8-1.8
Delta time in open arm before/after self-admin0.80.82.0-1.10.40.60.61.40.8-0.81.10.6
Diff in mean of infusions in LGA sessions0.40.51.6-0.10.20.50.9-0.51.0-0.50.31.3
Delay discount exponential model param0.40.40.9-0.90.70.70.80.70.2-0.50.60.6
Extinction: sum of active levers before priming4.04.05.71.8-1.8-1.8-1.9-2.4-1.92.1-2.3-2.1
Active lever presses in extinction session 63.53.45.01.4-1.7-1.5-1.4-2.2-1.42.2-2.2-2.0
Bone: final force1.72.73.01.6-1.7-1.7-1.7-1.6-1.51.6-1.6-1.7
Bone: final moment2.23.53.71.8-1.9-1.9-1.9-1.8-1.81.8-1.9-1.9
Food consumed during 24 hour testing period0.70.91.51.2-1.0-1.0-1.0-1.0-0.80.7-0.9-0.7
Glucose0.20.20.5-0.70.50.50.70.60.1-0.20.40.0
Heart weight0.10.10.50.7-0.1-0.1-0.4-0.4-0.50.1-0.1-0.1
Delay discount hyperbolic model param0.30.30.7-0.80.60.60.70.60.2-0.40.40.4
Intermittent access intake day 1-15 change2.12.13.41.4-1.5-1.5-1.6-1.2-1.81.3-1.0-1.4
Intermittent access intake escalation1.91.93.31.5-1.4-1.4-1.6-1.0-1.81.2-1.0-1.3
Intermittent access intake escalation 21.61.62.01.3-1.3-1.3-1.4-1.0-1.41.2-1.1-1.4
Intermitt. access day 1 inactive lever presses4.04.35.52.1-2.2-2.2-2.2-2.0-1.32.0-2.4-2.1
Intermitt. access day 15 inactive lever presses0.30.41.01.0-0.6-0.6-0.8-0.3-0.20.4-0.6-0.4
Intermitt. access escalation Index0.30.20.8-0.10.40.40.50.30.1-0.50.50.9
Intermittent access day 1 total infusions2.73.14.6-1.21.81.91.81.61.4-2.11.82.2
Intermittent access day 15 total infusions0.20.30.60.30.50.50.20.4-0.1-0.70.60.8
Intermittent access terminal intake (last 3 days)0.50.61.30.00.70.90.60.60.4-1.00.91.1
Intermittent access total infusions0.91.01.9-0.31.11.20.80.90.5-1.31.11.4
Intermittent access day 1 locomotion1.11.22.7-0.51.01.01.10.61.1-1.41.01.6
Intermittent access day 15 total locomotion0.20.20.60.40.10.20.1-0.1-0.1-0.70.40.8
Intermittent access total locomotion1.21.42.5-0.71.11.21.20.81.2-1.51.21.6
Intermittent access standard deviation4.95.27.22.7-2.3-2.3-2.5-2.4-2.32.0-2.1-1.9
Left kidney weight2.57.010.02.2-2.5-2.5-2.8-2.0-3.22.8-2.6-2.9
Right kidney weight4.813.415.93.2-3.6-3.5-3.8-3.4-4.03.9-3.7-3.9
Cocaine induced anxiety0.60.71.10.7-0.9-1.0-0.7-0.9-0.51.0-1.0-0.9
Post-drug Anxiety0.10.10.5-0.20.20.20.00.10.70.1-0.1-0.2
Baseline Anxiety1.41.52.0-1.11.31.30.91.41.4-1.31.31.1
Tail length4.914.817.23.6-4.1-4.1-3.9-3.6-3.74.0-3.5-4.0
Length with tail8.129.732.05.4-5.7-5.6-5.5-5.5-5.65.5-4.9-5.3
Length without tail5.311.614.83.4-3.5-3.5-3.6-3.4-3.93.2-3.0-3.2
Times rat made contact with spout0.70.81.4-1.21.01.01.01.10.2-0.70.8-0.4
Lifetime Intake1.11.21.8-0.61.31.31.01.10.6-1.31.11.3
Liver weight, left0.40.71.3-1.20.90.80.71.10.6-0.60.80.2
Liver weight, right0.10.20.5-0.60.40.30.30.40.7-0.20.5-0.0
Locomotor activity0.30.51.3-1.10.70.70.80.60.8-0.30.30.2
Locomotor testing distance0.30.51.0-1.00.80.70.90.70.6-0.40.40.5
Locomotor testing rearing2.13.35.4-2.01.81.81.82.31.2-1.72.01.6
Locomotion in novel chamber0.10.20.9-0.30.30.30.4-0.21.0-0.0-0.20.4
Locomotion in novel chamber post-restriction0.20.20.60.4-0.3-0.40.0-0.60.50.5-0.8-0.1
Fecal boli incidents, locomotor time 11.71.94.0-1.31.51.51.50.82.0-1.10.91.5
Change in fecal boli incidents, locomotor task0.30.30.80.0-0.8-0.6-0.5-0.3-0.00.6-0.4-0.9
Time >=10cm from walls, locomotor time 10.10.10.2-0.20.30.4-0.10.10.3-0.20.2-0.3
Bouts of movement, locomotor time 10.50.61.51.2-0.8-0.7-0.5-1.2-0.70.5-0.4-0.0
Total resting periods, locomotor time 10.50.51.51.1-0.8-0.5-0.5-1.2-0.50.5-0.5-0.0
Rest time, locomotor task time 10.80.92.3-0.90.60.91.20.01.5-0.70.71.0
Distance moved, locomotor task time 10.10.10.40.10.10.1-0.00.5-0.7-0.10.20.1
Vertical activity count, locomotor time 11.81.93.01.4-1.7-1.7-1.5-0.7-1.61.2-1.1-1.2
Time >=10cm from walls, locomotor time 21.71.82.8-1.21.11.41.40.91.7-1.31.31.4
Bouts of movement, locomotor time 20.00.00.20.10.00.40.2-0.2-0.2-0.10.3-0.0
Total resting periods, locomotor time 20.00.00.1-0.1-0.00.40.3-0.00.1-0.20.30.0
Rest time, locomotor task time 20.30.41.4-0.60.30.40.70.21.2-0.50.50.4
Distance moved, locomotor task time 20.20.30.8-0.30.30.30.30.9-0.3-0.60.70.6
Vertical activity count, locomotor time 20.70.71.41.0-1.0-1.0-1.0-0.6-1.20.6-0.5-0.6
Light reinforcement 10.10.10.3-0.30.20.30.20.30.2-0.60.50.5
Light reinforcement 22.33.14.1-1.91.71.81.81.72.0-1.81.61.6
Bone: marrow area1.94.14.82.0-2.2-2.2-2.0-2.0-1.82.0-2.1-1.7
Bone: maximum diameter1.42.52.91.6-1.6-1.6-1.7-1.5-1.61.6-1.5-1.6
Bone: maximum force2.64.54.82.2-2.2-2.2-2.2-2.1-2.12.0-2.1-2.2
Bone: maximum moment3.15.35.62.3-2.4-2.4-2.4-2.3-2.32.2-2.2-2.3
Mean time between licks in bursts0.00.00.10.2-0.2-0.2-0.3-0.10.4-0.10.00.4
Mean num. licks in bursts1.51.83.10.9-1.2-1.2-1.1-1.3-1.31.6-1.5-1.8
Cd content in liver0.10.10.40.0-0.0-0.0-0.1-0.1-0.60.2-0.2-0.3
Co content in liver0.20.30.5-0.70.30.30.40.60.7-0.50.40.6
Cu content in liver0.50.50.90.7-0.9-0.9-0.7-0.6-0.80.6-0.5-0.6
Fe content in liver0.00.00.0-0.10.10.10.10.10.2-0.10.00.1
K content in liver0.10.10.20.2-0.3-0.3-0.4-0.20.40.1-0.10.0
Mg content in liver0.50.51.5-0.80.50.50.40.71.2-0.60.70.6
Mn content in liver0.80.92.1-1.20.80.80.90.81.4-0.70.80.4
Na content in liver1.31.32.21.5-1.2-1.2-1.3-1.1-1.21.0-0.9-0.8
Rb content in liver0.10.10.50.00.10.10.20.20.6-0.50.40.7
Se content in liver7.59.210.8-3.33.13.13.03.13.3-2.92.92.6
Sr content in liver0.70.61.1-1.00.80.80.80.81.0-0.60.60.6
Zn content in liver0.10.10.3-0.30.00.00.10.40.5-0.30.20.3
Bone: minimum diameter3.15.77.52.7-2.6-2.6-2.4-2.6-2.22.2-2.2-1.8
Time in familiar zone, hab. session 10.50.51.10.2-0.5-0.5-0.4-0.5-0.90.9-0.6-1.1
Time in novel zone, hab. session 11.51.52.4-0.81.11.10.91.11.6-1.41.41.4
Total zone transitions, hab. session 10.00.00.20.1-0.1-0.10.4-0.1-0.0-0.10.00.4
Total locomotion distance, hab. session 11.21.72.61.4-1.4-1.4-1.1-1.6-0.71.3-1.3-1.0
Locomotion velocity, hab. session 10.81.11.81.1-1.2-1.2-0.8-1.3-0.51.2-1.2-0.9
Time in familiar zone, hab. session 22.62.73.41.4-1.8-1.8-1.6-1.9-0.91.8-1.7-1.6
Time in novel zone, hab. session 21.71.72.2-1.21.51.51.31.50.8-1.41.41.1
Total zone transitions, hab. session 23.03.94.5-1.91.81.82.11.92.1-2.02.02.1
Total locomotion distance, hab. session 20.10.20.6-0.10.10.10.40.10.8-0.40.40.5
Locomotion velocity, hab. session 20.20.20.8-0.30.20.20.60.20.9-0.50.40.5
Novel to familiar place preference ratio0.10.10.20.4-0.2-0.2-0.5-0.1-0.40.1-0.0-0.2
Novelty place preference0.00.00.10.3-0.1-0.1-0.3-0.0-0.3-0.00.1-0.0
Time in novel zone, NPP test0.00.00.10.10.10.1-0.10.2-0.2-0.20.30.2
Total zone transitions, NPP test0.00.10.2-0.30.10.10.50.10.1-0.20.10.3
Total locomotion distance, NPP test2.63.54.01.8-2.0-2.0-1.7-2.0-1.62.0-2.0-1.9
Locomotion velocity, NPP test2.84.04.51.9-2.1-2.1-1.8-2.1-1.62.1-2.1-2.1
Intraocular pressure0.00.10.20.20.20.20.1-0.20.0-0.2-0.00.5
Delta distance traveled before/after self-admin4.65.06.52.3-2.4-2.6-2.5-1.9-2.22.0-2.0-2.1
Delta ambulatory time before/after self-admin5.25.77.32.4-2.5-2.7-2.7-2.1-2.42.1-2.1-2.3
Parametrial fat weight0.20.41.3-1.10.30.20.00.50.40.3-0.0-1.2
Pavlov. Cond. lever latency0.10.20.60.4-0.2-0.2-0.3-0.4-0.80.4-0.4-0.4
Pavlov. Cond. magazine entry latency0.40.50.8-0.80.60.60.70.80.9-0.60.80.4
Pavlov. Cond. change in total contacts0.30.30.7-0.30.20.20.50.50.8-0.60.50.8
Pavlov. Cond. index score0.40.61.3-0.80.50.50.70.81.2-0.70.70.5
Pavlov. Cond. latency score0.20.30.9-0.50.30.30.50.51.0-0.50.50.4
Pavlov. Cond. lever contacts0.10.10.20.2-0.4-0.4-0.3-0.30.50.2-0.2-0.0
Pavlov. Cond. magazine entry number0.50.71.10.9-0.7-0.7-0.8-0.9-1.00.8-0.9-0.5
Pavlov. Cond. intertrial magazine entries0.81.01.4-0.91.01.01.10.90.8-0.90.91.2
Pavlov. Cond. lever-magazine prob. diff.0.60.71.6-0.90.60.60.80.91.3-0.80.90.6
Pavlov. Cond. response bias0.10.10.5-0.50.20.20.30.40.7-0.20.30.0
Pavlov. Cond. lever latency5.06.87.5-2.72.72.72.62.72.5-2.52.62.5
Pavlov. Cond. magazine entry latency3.03.54.22.0-1.9-1.9-2.0-2.1-1.41.8-1.9-1.8
Pavlov. Cond. change in total contacts7.810.813.53.7-3.3-3.3-3.4-3.4-3.43.1-3.1-2.8
Pavlov. Cond. index score5.16.67.42.7-2.6-2.6-2.6-2.7-2.42.5-2.5-2.6
Pavlov. Cond. latency score4.96.16.92.6-2.5-2.5-2.5-2.6-2.32.4-2.4-2.4
Pavlov. Cond. lever contacts4.46.06.82.6-2.5-2.5-2.4-2.4-2.52.3-2.3-2.5
Pavlov. Cond. magazine entry number3.84.65.2-2.22.12.12.12.12.3-2.12.12.3
Pavlov. Cond. intertrial magazine entries0.91.11.6-1.20.90.91.11.31.0-1.10.91.2
Pavlov. Cond. lever-magazine prob. diff.5.06.47.02.6-2.5-2.5-2.6-2.6-2.42.5-2.5-2.6
Pavlov. Cond. response bias4.96.67.82.8-2.6-2.6-2.6-2.5-2.72.4-2.4-2.5
Time in closed arm before self-admin3.13.54.2-1.52.01.91.82.11.6-1.92.02.0
Time in closed arm after self-admin0.10.10.30.50.1-0.1-0.0-0.50.00.2-0.50.1
Time in open arm before self-admin5.76.28.22.1-2.5-2.4-2.5-2.6-2.12.5-2.7-2.9
Time in open arm after self-admin1.31.42.50.8-1.5-1.3-1.5-0.6-1.11.1-0.9-1.6
Bone: periosteal estimation2.14.44.72.1-2.2-2.2-2.1-2.1-2.12.1-2.1-2.0
Bone: periosteal perimeter1.42.33.11.5-1.5-1.4-1.5-1.8-1.41.6-1.5-1.5
Bone: post-yield work1.72.33.51.9-1.7-1.7-1.6-1.5-1.51.2-1.5-1.0
Progressive ratio test 1 active lever presses0.30.30.91.0-0.6-0.4-0.4-0.7-0.80.2-0.50.1
Progressive ratio test 1 breakpoint0.70.71.41.2-0.9-0.7-0.7-1.1-1.00.5-0.9-0.3
Progressive ratio test 1 inactive lever presses0.30.41.21.1-0.7-0.7-0.6-0.6-0.30.2-0.4-0.0
Progressive ratio test 2 active lever presses0.10.10.30.40.40.50.20.0-0.3-0.40.20.6
Progressive ratio test 2 breakpoint0.10.20.40.30.50.60.2-0.0-0.2-0.40.20.6
Progressive ratio test 2 inactive lever presses0.60.72.81.7-0.5-0.4-0.5-1.5-0.40.2-0.70.4
Incentive Sensitization - Responses0.30.30.6-0.00.80.80.50.4-0.0-0.50.30.7
Incentive Sensitization - Breakpoint0.30.30.6-0.10.80.80.40.4-0.1-0.50.40.6
Sum of active levers in priming session hrs 5-60.20.20.50.4-0.3-0.3-0.1-0.5-0.40.5-0.7-0.2
Progressive ratio0.10.10.30.2-0.4-0.4-0.20.00.10.3-0.6-0.0
Food seeking constrained by brief footshock3.54.35.32.2-2.1-2.1-2.1-2.2-1.72.1-2.3-1.9
Seeking ratio, punishment vs. effort0.50.61.10.9-0.7-0.6-0.8-1.1-0.80.6-0.5-0.7
Retroperitoneal fat weight1.44.77.1-2.72.42.42.12.51.7-1.92.11.2
Reaction time number correct0.00.00.1-0.3-0.1-0.10.20.4-0.1-0.20.3-0.1
Reaction time mean minus median0.50.61.10.7-0.6-0.8-1.0-0.6-0.80.8-0.7-1.0
Reaction time mean minus median AUC1.01.22.10.8-1.0-1.2-1.4-0.7-1.31.0-0.9-1.5
Reaction time num false alarms1.11.52.1-1.11.41.30.91.30.9-1.31.31.2
Reaction time num false alarms AUC1.21.72.4-1.21.61.41.11.41.1-1.41.21.2
Reaction time trials correct on left0.00.00.1-0.3-0.1-0.10.20.4-0.1-0.20.3-0.1
Reaction time trials on left0.00.10.2-0.3-0.1-0.10.10.4-0.1-0.20.3-0.1
Reaction time mean0.10.20.70.3-0.0-0.2-0.60.1-0.80.2-0.3-0.6
Reaction time mean AUC0.10.10.40.10.0-0.1-0.50.2-0.60.2-0.3-0.6
Median of all reaction times0.00.10.30.10.20.1-0.20.3-0.6-0.1-0.1-0.3
Reaction time omissions0.00.00.2-0.30.20.0-0.20.40.0-0.00.2-0.0
Reaction time false alarm rate0.71.01.7-0.81.31.20.81.00.9-1.10.91.1
Reaction time premature initiation rate0.20.20.50.5-0.7-0.7-0.2-0.60.20.2-0.30.2
Reaction time premature initiations0.10.10.40.3-0.6-0.7-0.1-0.40.10.0-0.10.2
Std. dev. reaction times0.60.81.70.8-0.6-0.8-1.2-0.5-1.30.7-0.7-1.0
Reaction time trials completed0.00.10.2-0.3-0.1-0.10.10.4-0.1-0.20.3-0.1
Reaction time trials AUC0.10.10.2-0.50.00.00.20.5-0.1-0.20.3-0.1
Run reversals in cocaine runway, females0.40.41.50.7-0.4-0.6-0.8-0.3-1.20.3-0.4-0.4
Run reversals in cocaine runway, males0.30.31.1-0.80.10.1-0.10.70.50.2-0.0-1.0
Latency to leave start box in cocaine runway0.10.10.50.4-0.3-0.3-0.1-0.1-0.7-0.10.00.3
Latency to leave start box in cocaine runway, F0.10.10.30.0-0.1-0.00.00.5-0.2-0.40.40.2
Latency to leave start box in cocaine runway, M0.10.10.30.1-0.1-0.10.1-0.3-0.50.10.10.3
Std. dev. time between licks in bursts0.50.51.21.1-0.9-0.9-0.8-0.90.30.3-0.40.5
Total sessions with >9 infusions1.31.42.6-1.21.21.21.11.60.9-1.21.11.0
Short access day 1 total inactive lever presses0.20.20.90.9-0.4-0.4-0.2-0.7-0.1-0.2-0.00.6
Short access day 10 total inactive lever presses1.51.72.81.6-1.2-1.2-1.2-1.7-0.81.2-1.5-0.8
Short access day 1 total infusions0.20.20.5-0.30.40.50.40.70.1-0.50.50.6
Short access day 10 total infusions0.60.61.0-0.60.91.00.70.80.4-0.90.60.8
Short access total infusions1.21.32.0-1.11.31.41.11.30.7-1.21.01.1
Short access day 1 locomotion0.30.30.6-0.70.30.40.30.70.5-0.80.60.3
Short access day 10 total locomotion0.91.02.11.1-1.1-1.1-0.9-1.4-0.40.6-1.1-0.5
Short access total locomotion0.70.71.2-0.90.80.80.80.51.1-1.00.80.9
One hour access (0.3 mA shock)0.70.82.11.5-0.7-0.7-1.0-0.9-1.10.5-0.7-0.4
Compulsive drug intake0.00.00.10.2-0.2-0.2-0.20.3-0.20.20.2-0.1
One hour access (shock baseline)0.10.10.20.50.20.2-0.0-0.4-0.2-0.3-0.00.4
Social response proportion2.42.63.51.8-1.6-1.7-1.6-1.9-0.91.6-1.8-1.3
Social responses1.01.32.01.1-1.3-1.4-1.2-1.4-0.11.1-1.3-0.7
Social time2.83.74.72.2-1.9-2.0-2.0-2.0-1.91.7-2.0-1.5
Soleus weight0.10.20.5-0.70.20.30.50.60.4-0.30.40.3
Bone: stiffness1.32.12.41.5-1.5-1.5-1.4-1.5-1.31.3-1.4-1.5
Tibialis anterior weight0.00.20.5-0.70.20.20.40.5-0.30.10.3-0.3
Time to tail flick, vehicle, before self-admin1.11.12.2-0.91.51.21.00.61.0-1.10.91.1
Time to tail flick, vehicle, after self-admin0.10.10.50.2-0.1-0.1-0.0-0.70.50.3-0.2-0.1
Time to tail flick, test, before self-admin0.80.81.6-0.30.90.60.51.3-0.0-1.21.21.0
Time to tail flick, test, after self-admin0.00.00.2-0.1-0.1-0.1-0.0-0.2-0.1-0.30.40.0
Delta time to tail flick, vehicle, before/after SA0.90.91.60.9-1.3-1.1-0.9-0.9-0.50.9-0.8-0.9
Delta time to tail flick, test, before/after SA0.10.10.3-0.6-0.3-0.00.2-0.40.60.20.0-0.3
Tibia length2.77.610.72.7-2.6-2.7-2.7-2.5-3.32.7-2.7-3.0
Ambulatory time before self-admin0.10.10.10.1-0.2-0.00.4-0.20.20.2-0.30.4
Ambulatory time after self-admin7.68.310.13.2-3.1-3.0-2.8-2.8-2.82.7-3.0-2.4
Bone: tissue strength3.13.04.12.0-1.9-1.9-2.0-1.6-1.71.5-1.5-1.6
Total heroin consumption0.50.61.81.0-0.7-0.5-0.3-1.4-0.40.6-1.0-0.1
Bone: trabecular number1.52.43.01.4-1.6-1.6-1.5-1.3-1.61.5-1.7-1.7
Bone: trabecular spacing0.20.30.40.4-0.6-0.6-0.6-0.6-0.10.7-0.3-0.5
Bone: trabecular thickness0.10.20.4-0.40.40.40.30.6-0.3-0.40.40.1
Bone: trabecular tissue density2.23.15.2-2.32.12.12.01.91.4-1.31.60.9
Water consumed over 24 hours0.40.50.90.6-0.7-0.7-0.7-0.6-0.80.6-0.7-1.0
Number of responses in last shaping day0.30.31.10.3-0.10.30.4-0.70.2-0.40.51.0