Hub : Genes

Polr2i

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Polr2i 0.03 0.02 1.7e-04 0.01 0.01 0.01 0 3.0e-03 2.3e-02 1.5e-02 4.5e-02
2 Liver gene expression Polr2i 0.07 0.05 1.2e-08 0.06 0.05 0.05 0.05 9.7e-07 2.3e-06 5.9e-06 2.9e-06
3 LHb mRNA stability Polr2i 0.14 0.1 2.4e-03 0.12 0.12 0.11 0.01 7.4e-04 1.0e-03 1.2e-03 2.0e-01
4 pVTA mRNA stability Polr2i 0.04 0.03 3.6e-03 0.01 0.02 0.01 0.02 2.2e-02 6.2e-03 4.6e-02 1.1e-02
5 BLA gene expression Polr2i 0.06 0.05 7.8e-04 0.05 0.06 0.04 0.04 9.4e-04 4.0e-04 2.1e-03 2.6e-03
6 pVTA gene expression Polr2i 0.05 0.04 2.0e-04 0.02 0.03 0.02 0.02 5.4e-03 1.2e-03 1.7e-02 7.7e-03
7 NAcc mRNA stability Polr2i 0.03 0.02 2.4e-06 0.05 0.04 0.04 0.04 1.6e-07 4.1e-06 9.8e-07 5.3e-07
8 RMTg intron excision ratio chr1_94611335_94611490 0.18 0.09 1.9e-05 0.14 0.12 0.12 0.1 1.8e-04 4.7e-04 5.1e-04 1.2e-03
9 RMTg intron excision ratio chr1_94611412_94611490 0.14 0.08 3.0e-04 0.12 0.08 0.08 0.07 5.4e-04 3.2e-03 3.8e-03 6.0e-03
10 LHb intron excision ratio chr1_94611335_94611490 0.22 0.13 7.8e-05 0.13 0 0.06 -0.01 5.5e-04 2.9e-01 1.4e-02 8.7e-01
11 LHb intron excision ratio chr1_94611412_94611490 0.24 0.14 6.2e-05 0.14 0 0.08 -0.01 4.5e-04 2.7e-01 7.0e-03 8.5e-01
12 Liver mRNA stability Polr2i 0.04 0.03 3.6e-05 0.03 0.03 0.02 0.03 2.6e-04 4.0e-04 3.3e-03 5.4e-04
13 PL mRNA stability Polr2i 0.04 0.04 4.4e-04 0.04 0.03 0.04 0.03 8.5e-05 2.6e-04 3.4e-05 3.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.61.01.80.51.11.40.80.70.81.0-1.31.3-0.50.51.31.3
Area under the delay curve0.70.81.61.30.60.90.81.00.80.8-1.01.0-1.11.10.30.6
BMI with tail0.10.20.5-0.3-0.4-0.4-0.4-0.3-0.3-0.70.3-0.30.4-0.4-0.3-0.6
BMI without tail0.41.12.41.61.00.91.01.11.00.7-0.70.7-1.51.50.70.6
Body weight3.013.316.13.53.94.03.73.63.73.5-4.04.0-3.23.23.93.1
Weight adjusted by age0.10.10.3-0.20.10.50.20.00.20.5-0.50.50.5-0.50.6-0.0
Bone surface1.42.63.61.31.81.91.61.71.71.6-1.91.9-1.21.21.81.3
Bone volume1.52.63.91.21.72.01.61.61.71.6-2.02.0-1.11.12.01.4
Breakpoint value in progressive ratio session1.41.63.01.71.01.11.31.51.31.0-1.01.0-1.71.70.90.8
Number of licking bursts2.94.76.5-2.2-2.3-2.1-2.1-2.0-1.9-2.32.0-2.02.3-2.3-1.9-2.6
Context. condit. distance diff. score0.00.10.60.1-0.2-0.10.10.20.2-0.20.2-0.2-0.10.10.2-0.7
Locomotion velocity, session 10.50.51.0-0.8-0.7-0.5-0.9-0.9-0.9-1.00.6-0.60.6-0.6-0.5-0.1
Locomotion distance, session 10.50.61.30.70.90.80.70.90.90.4-0.70.7-0.90.91.10.2
Locomotion velocity, session 20.60.71.4-0.4-0.5-1.1-0.9-0.8-0.9-0.91.2-1.20.6-0.6-1.1-0.5
Locomotion distance, session 21.41.92.8-1.3-1.3-1.4-1.4-1.2-1.2-1.61.4-1.41.3-1.3-1.3-1.7
Locomotion velocity, session 30.30.30.5-0.6-0.7-0.6-0.5-0.6-0.5-0.50.6-0.60.5-0.5-0.4-0.7
Locomotion distance, session 33.03.34.92.11.71.42.12.22.21.9-1.31.3-2.22.21.60.4
Stereotopy head waving bouts, day 30.70.81.4-1.2-0.6-0.6-1.0-1.1-1.2-0.80.6-0.61.0-1.0-0.80.4
Stereotopy head waving duration, day 31.41.72.9-1.6-1.2-0.9-1.5-1.6-1.7-1.31.0-1.01.4-1.4-1.30.1
Locomotion velocity, session 70.30.30.60.40.70.50.70.80.80.6-0.50.5-0.40.40.6-0.0
Locomotion distance, session 70.10.20.50.30.40.30.50.50.60.4-0.30.3-0.40.40.70.0
Stereotopy head waving bouts, day 71.61.82.4-1.3-1.5-1.2-1.4-1.3-1.3-1.51.2-1.21.3-1.3-1.3-1.5
Stereotopy head waving duration, day 72.12.53.2-1.5-1.6-1.5-1.7-1.7-1.7-1.81.5-1.51.6-1.6-1.7-1.3
Locomotion velocity, session 84.04.85.5-2.1-2.1-2.2-2.1-2.0-1.9-2.22.3-2.32.3-2.3-2.1-2.3
Locomotion distance, session 80.71.13.8-0.9-1.0-1.1-0.8-0.6-0.5-1.21.2-1.20.8-0.8-0.7-1.9
Degree of sensitization distance0.60.61.3-1.0-0.7-0.5-0.9-1.0-0.9-0.80.5-0.51.1-1.1-0.4-0.0
Degree of sensitization stereotypy1.21.22.7-1.0-1.3-1.0-1.1-1.0-0.9-1.31.0-1.01.1-1.1-1.0-1.6
Conditioned locomotion0.40.50.9-0.2-0.7-0.6-0.7-0.6-0.7-0.90.8-0.80.3-0.3-1.0-0.6
Cocaine response after cond. corrected0.10.10.20.1-0.1-0.5-0.3-0.4-0.5-0.20.4-0.4-0.00.0-0.20.5
Cocaine response after cond. not corrected0.10.10.60.20.1-0.3-0.2-0.4-0.40.00.3-0.3-0.10.10.00.8
Cocaine response before conditioning1.21.52.01.01.31.41.21.21.21.2-1.31.3-1.01.01.41.1
Saline control response0.10.10.30.1-0.2-0.6-0.3-0.3-0.4-0.50.5-0.50.2-0.2-0.3-0.0
Bone: connectivity density0.20.40.70.20.80.80.50.50.60.7-0.70.7-0.20.20.60.7
Bone: cortical apparent density1.62.33.1-1.7-1.8-1.5-1.6-1.5-1.4-1.61.4-1.41.5-1.5-1.1-1.4
Bone: cortical area1.52.43.11.81.61.51.61.51.61.6-1.41.4-1.51.51.61.3
Bone: cortical porosity1.01.12.1-1.4-0.9-0.8-0.9-0.8-0.8-0.80.8-0.81.5-1.5-1.2-1.3
Bone: cortical porosity1.61.83.0-1.6-1.1-1.1-1.2-1.0-1.0-1.11.1-1.11.7-1.7-1.5-1.7
Bone: cortical thickness0.60.91.41.20.91.01.00.80.91.0-0.90.9-1.01.01.01.0
Bone: cortical thickness0.60.70.9-0.8-0.9-0.8-0.9-1.0-0.9-0.90.9-0.90.8-0.8-0.8-0.5
Bone: cortical tissue density1.92.63.4-1.8-1.9-1.7-1.7-1.6-1.5-1.71.5-1.51.6-1.6-1.2-1.6
Condit. Reinf. active minus inactive responses0.20.20.3-0.2-0.6-0.4-0.5-0.5-0.5-0.50.3-0.30.3-0.3-0.6-0.2
Condit. Reinf. active-inactive response ratio0.20.20.5-0.2-0.4-0.3-0.5-0.6-0.7-0.20.2-0.20.2-0.2-0.70.5
Condit. Reinf. active responses2.02.43.1-1.3-1.7-1.7-1.7-1.5-1.6-1.81.6-1.61.3-1.3-1.7-1.4
Condit. Reinf. inactive responses2.32.84.6-1.5-1.7-1.9-1.6-1.4-1.4-1.91.8-1.81.4-1.4-1.6-2.1
Incentive salience index mean0.10.20.4-0.0-0.5-0.6-0.4-0.4-0.5-0.40.5-0.50.1-0.1-0.6-0.3
Condit. Reinf. lever presses0.10.10.20.40.1-0.40.00.10.0-0.00.3-0.3-0.40.4-0.3-0.3
Condit. Reinf. active minus inactive responses1.41.84.02.01.50.91.41.41.21.5-0.80.8-1.61.60.81.3
Condit. Reinf. active-inactive response ratio0.10.10.30.4-0.3-0.5-0.2-0.2-0.2-0.20.6-0.6-0.00.0-0.4-0.2
Condit. Reinf. active responses3.54.97.12.72.51.92.42.42.22.4-1.81.8-2.52.51.71.9
Condit. Reinf. inactive responses4.15.47.12.22.72.22.52.62.52.6-2.12.1-2.42.41.91.6
Condit. Reinf. lever presses7.910.913.43.73.53.33.43.43.23.4-3.13.1-3.43.42.93.1
Condit. Reinf. lever reinforcers received3.85.37.62.72.52.12.52.52.42.5-1.91.9-2.52.51.91.8
Conditioned reinforcement - actives0.61.01.4-1.0-1.2-1.1-1.1-1.1-1.0-1.00.8-0.81.0-1.0-0.8-0.8
Conditioned reinforcement - inactives0.10.20.50.60.50.10.50.70.60.3-0.20.2-0.40.4-0.1-0.6
Conditioned locomotion2.53.24.1-2.0-1.7-1.9-1.9-1.8-1.8-1.81.8-1.81.8-1.8-1.8-1.4
Patch foraging indifference point 0 sec0.10.10.60.10.50.10.50.40.30.8-0.20.2-0.30.3-0.00.1
Patch foraging indifference point AUC0.71.01.5-0.9-0.8-0.9-1.0-1.0-1.0-1.01.0-1.01.1-1.1-1.2-0.7
Delay disc. indifference point, 0s delay0.50.51.61.30.40.20.50.80.7-0.1-0.80.8-1.01.00.5-0.3
Delay disc. indifference point, 16s delay1.41.53.71.90.61.11.21.31.11.0-1.11.1-1.61.60.21.1
Delay disc. indifference point, 2s delay1.11.21.81.31.00.91.11.31.31.0-1.31.3-1.01.01.00.4
Delay disc. indifference point, 24s delay2.32.53.21.81.51.61.71.71.71.7-1.41.4-1.81.81.11.4
Delay disc. indifference point, 4s delay0.10.10.20.40.00.30.10.20.10.1-0.40.4-0.30.3-0.3-0.3
Delay disc. indifference point, 8s delay0.20.30.70.10.40.80.40.40.40.6-0.70.7-0.50.50.20.4
Indifference point function ln k0.30.50.90.80.50.50.60.70.70.7-0.60.6-1.01.00.50.6
Indifference point function log k0.30.50.90.80.50.50.60.70.70.7-0.60.6-1.01.00.50.6
Patch foraging total patch changes 0 sec0.10.20.80.30.60.20.60.60.50.9-0.30.3-0.50.50.10.2
Patch foraging total patch changes 12 sec0.00.10.20.10.2-0.10.0-0.0-0.20.10.2-0.2-0.20.2-0.50.4
Patch foraging total patch changes 18 sec0.20.20.8-0.9-0.2-0.3-0.2-0.2-0.2-0.10.3-0.30.8-0.8-0.2-0.8
Patch foraging total patch changes 24 sec0.50.81.21.00.81.01.01.01.10.9-0.90.9-0.70.71.1-0.1
Patch foraging total patch changes 6 sec0.00.10.1-0.30.3-0.20.20.0-0.00.40.2-0.20.3-0.3-0.30.0
Patch foraging time to switch 0 sec0.30.71.1-0.3-0.9-1.0-0.9-1.0-1.1-1.01.0-1.00.2-0.2-1.0-0.3
Patch foraging water rate 0 sec0.61.22.3-1.5-0.7-1.0-0.9-0.9-0.9-0.81.0-1.01.5-1.5-1.0-1.0
Patch foraging water rate 12 sec0.50.91.80.70.61.31.00.91.11.0-1.31.3-0.40.41.30.2
Patch foraging water rate 18 sec0.20.20.8-0.8-0.30.1-0.3-0.4-0.4-0.20.0-0.00.9-0.9-0.5-0.1
Patch foraging water rate 24 sec0.10.20.8-0.2-0.10.00.20.30.4-0.1-0.30.30.6-0.6-0.1-0.9
Patch foraging water rate 6 sec0.91.32.10.71.21.31.31.31.41.3-1.41.4-0.40.41.20.2
Seeking ratio, delayed vs. immediate footshock1.41.72.51.50.91.41.41.51.51.2-1.61.6-1.21.21.4-0.1
Distance traveled before self-admin0.20.31.61.20.4-0.20.30.50.3-0.1-0.00.0-0.90.90.20.4
Distance traveled after self-admin2.22.73.61.51.91.71.71.71.71.6-1.61.6-1.51.51.61.7
Extensor digitorum longus weight0.20.61.2-0.6-0.8-0.5-1.0-1.1-1.0-1.00.5-0.51.0-1.0-0.4-0.1
Bone: elastic displacement0.00.00.1-0.2-0.10.10.0-0.1-0.10.1-0.10.10.1-0.10.10.4
Bone: elastic work1.92.53.21.51.51.81.61.51.51.6-1.81.8-1.51.51.71.6
Bone: endosteal estimation1.53.34.41.92.11.91.91.91.91.9-1.81.8-1.71.71.71.6
Bone: endosteal perimeter1.32.84.12.01.71.51.81.81.81.6-1.41.4-1.91.91.41.1
Epididymis fat weight0.00.10.2-0.2-0.10.4-0.1-0.10.1-0.1-0.50.50.4-0.40.40.1
Delta time in closed arm before/after self-admin1.21.11.90.71.41.31.01.01.01.1-1.21.2-0.70.71.00.9
Delta time in open arm before/after self-admin0.50.51.0-0.6-0.5-1.0-0.6-0.8-0.7-0.50.7-0.70.8-0.8-0.5-0.5
Diff in mean of infusions in LGA sessions0.40.51.2-0.2-0.4-1.0-0.6-0.4-0.6-0.91.1-1.1-0.00.0-1.1-0.7
Delay discount exponential model param0.80.91.5-1.2-0.7-1.1-0.9-1.0-0.9-1.01.1-1.11.1-1.1-0.3-0.7
Extinction: sum of active levers before priming3.64.05.51.71.82.21.81.81.91.9-1.81.8-2.32.32.22.1
Active lever presses in extinction session 61.51.54.81.21.31.11.00.90.81.0-1.01.0-1.41.41.12.2
Bone: final force1.93.04.11.51.82.01.71.71.71.8-1.91.9-1.51.51.91.5
Bone: final moment2.43.94.91.82.02.22.02.02.02.1-2.12.1-1.81.82.21.7
Food consumed during 24 hour testing period0.60.81.30.90.91.01.01.11.11.0-0.90.9-0.80.80.60.3
Glucose0.30.40.8-0.8-0.6-0.3-0.8-0.9-0.8-0.70.3-0.30.8-0.8-0.40.2
Heart weight0.10.20.50.70.40.60.40.40.40.2-0.40.4-0.30.30.10.0
Delay discount hyperbolic model param0.60.71.1-1.1-0.5-0.9-0.8-0.9-0.8-0.81.0-1.00.9-0.9-0.3-0.5
Intermittent access intake day 1-15 change1.12.23.91.11.51.61.61.51.71.6-1.81.8-0.90.92.00.8
Intermittent access intake escalation0.81.63.30.71.21.31.31.21.41.4-1.71.7-0.60.61.80.7
Intermittent access intake escalation 21.21.41.71.21.21.31.21.11.21.3-1.21.2-1.11.11.21.0
Intermitt. access day 1 inactive lever presses1.76.39.22.72.72.42.62.82.62.7-2.12.1-3.03.01.71.8
Intermitt. access day 15 inactive lever presses0.61.32.11.21.11.11.31.41.31.3-0.90.9-1.31.30.60.2
Intermitt. access escalation Index0.10.10.5-0.1-0.4-0.6-0.3-0.1-0.1-0.50.3-0.30.3-0.3-0.2-0.7
Intermittent access day 1 total infusions1.52.55.2-1.3-1.8-1.8-1.5-1.3-1.3-1.91.5-1.51.2-1.2-1.3-2.3
Intermittent access day 15 total infusions0.10.11.0-0.2-0.6-0.4-0.10.00.2-0.3-0.20.20.2-0.20.3-1.0
Intermittent access terminal intake (last 3 days)0.20.31.9-0.2-0.8-0.7-0.3-0.2-0.2-0.70.4-0.40.2-0.2-0.3-1.4
Intermittent access total infusions0.60.72.5-0.7-1.2-1.0-0.7-0.5-0.4-1.00.6-0.60.6-0.6-0.5-1.6
Intermittent access day 1 locomotion0.81.13.5-0.6-1.0-1.3-0.8-0.5-0.6-1.21.2-1.20.5-0.5-1.1-1.9
Intermittent access day 15 total locomotion0.10.11.1-0.4-0.0-0.40.00.20.3-0.20.1-0.10.2-0.20.1-1.1
Intermittent access total locomotion1.11.42.9-1.1-1.1-1.4-1.1-0.8-0.9-1.31.3-1.30.9-0.9-1.1-1.7
Intermittent access standard deviation2.24.65.82.22.02.22.32.42.42.1-2.02.0-2.22.22.21.4
Left kidney weight2.09.313.22.62.93.43.12.83.13.2-3.63.6-2.32.33.62.6
Right kidney weight2.611.816.03.13.23.73.33.13.33.4-4.04.0-3.03.03.93.3
Cocaine induced anxiety0.00.00.10.00.1-0.0-0.0-0.0-0.0-0.0-0.00.0-0.10.1-0.00.3
Post-drug Anxiety0.10.10.40.5-0.1-0.1-0.10.0-0.1-0.10.2-0.2-0.30.3-0.60.1
Baseline Anxiety0.10.10.30.60.00.30.30.30.20.3-0.10.1-0.20.2-0.3-0.2
Tail length5.019.622.04.54.64.74.64.54.54.4-4.44.4-4.34.34.43.7
Length with tail7.030.435.05.45.95.95.75.55.65.6-5.95.9-5.05.05.54.7
Length without tail3.09.612.52.53.53.53.23.13.23.3-3.53.5-2.32.33.32.6
Times rat made contact with spout0.80.91.9-1.4-1.2-0.7-1.0-1.2-0.9-1.00.5-0.51.2-1.2-0.4-0.5
Lifetime Intake0.81.02.4-1.0-1.3-1.1-0.9-0.8-0.7-1.10.8-0.80.8-0.8-0.6-1.5
Liver weight, left0.50.91.3-1.0-1.1-0.8-0.9-1.0-1.0-1.01.0-1.00.9-0.9-0.9-0.7
Liver weight, right0.30.50.8-0.6-0.8-0.7-0.8-0.9-0.9-0.80.8-0.80.6-0.6-0.9-0.0
Locomotor activity0.50.81.5-1.1-0.7-0.7-1.0-1.2-1.2-0.80.7-0.71.1-1.1-0.70.3
Locomotor testing distance0.61.11.7-1.2-1.0-0.9-1.2-1.3-1.3-1.00.8-0.81.2-1.2-0.7-0.2
Locomotor testing rearing1.63.24.5-1.7-1.8-1.7-1.9-2.0-1.8-1.81.6-1.62.1-2.1-1.1-1.6
Locomotion in novel chamber0.20.31.0-0.1-0.3-0.6-0.5-0.4-0.6-0.60.8-0.8-0.20.2-1.00.3
Locomotion in novel chamber post-restriction0.20.31.21.00.3-0.10.00.2-0.1-0.20.3-0.3-1.11.1-0.50.5
Fecal boli incidents, locomotor time 12.23.25.1-1.4-1.7-2.0-1.9-1.8-2.0-1.82.3-2.31.3-1.3-2.3-0.7
Change in fecal boli incidents, locomotor task0.00.00.20.00.40.2-0.0-0.2-0.20.2-0.10.1-0.10.1-0.20.2
Time >=10cm from walls, locomotor time 10.00.00.1-0.1-0.30.3-0.1-0.2-0.20.20.2-0.2-0.10.1-0.20.0
Bouts of movement, locomotor time 10.80.92.51.60.90.71.01.21.10.5-0.50.5-1.11.10.80.5
Total resting periods, locomotor time 10.70.82.61.60.70.60.91.11.00.4-0.40.4-1.21.20.60.6
Rest time, locomotor task time 11.31.63.5-0.3-1.1-1.2-1.4-1.2-1.5-1.61.6-1.60.6-0.6-1.9-0.1
Distance moved, locomotor task time 10.10.10.6-0.3-0.1-0.20.20.10.30.1-0.30.30.3-0.30.5-0.8
Vertical activity count, locomotor time 10.82.03.20.91.81.21.61.51.71.8-1.61.6-1.01.01.60.1
Time >=10cm from walls, locomotor time 21.01.52.9-0.6-1.2-1.3-1.2-1.1-1.3-1.31.7-1.70.8-0.8-1.6-1.0
Bouts of movement, locomotor time 20.00.00.20.5-0.10.30.10.10.1-0.2-0.20.2-0.10.10.1-0.1
Total resting periods, locomotor time 20.00.00.10.2-0.10.1-0.1-0.1-0.1-0.30.1-0.10.0-0.0-0.1-0.1
Rest time, locomotor task time 20.30.40.9-0.2-0.4-0.5-0.6-0.6-0.8-0.70.8-0.80.3-0.3-1.0-0.1
Distance moved, locomotor task time 20.20.20.8-0.5-0.4-0.4-0.2-0.2-0.0-0.4-0.10.10.8-0.80.1-0.9
Vertical activity count, locomotor time 20.60.91.30.81.00.91.11.01.11.0-1.11.1-0.70.70.90.2
Light reinforcement 10.10.20.6-0.4-0.3-0.3-0.3-0.3-0.2-0.20.3-0.30.7-0.7-0.5-0.8
Light reinforcement 22.33.64.5-2.0-1.7-1.9-1.9-1.9-1.9-1.71.9-1.92.1-2.1-2.1-1.4
Bone: marrow area1.63.44.61.92.11.91.91.91.91.9-1.81.8-1.71.71.71.7
Bone: maximum diameter1.42.53.31.81.61.61.71.71.71.7-1.51.5-1.51.51.51.2
Bone: maximum force3.05.36.82.22.32.62.32.32.42.3-2.52.5-2.12.12.41.9
Bone: maximum moment3.66.37.52.52.52.72.62.52.62.5-2.62.6-2.32.32.62.0
Mean time between licks in bursts0.00.10.20.50.30.20.30.30.30.3-0.10.1-0.30.30.1-0.2
Mean num. licks in bursts1.11.73.51.11.21.31.11.01.01.3-1.41.4-1.21.21.51.9
Cd content in liver0.20.30.9-0.6-0.5-0.1-0.4-0.5-0.4-0.40.1-0.11.0-1.0-0.2-0.3
Co content in liver0.40.50.7-0.5-0.4-0.8-0.7-0.8-0.8-0.60.8-0.80.6-0.6-0.8-0.3
Cu content in liver1.01.22.10.71.51.21.21.21.21.1-1.31.3-0.60.61.30.8
Fe content in liver0.30.30.7-0.3-0.5-0.7-0.7-0.7-0.7-0.60.6-0.60.4-0.4-0.8-0.2
K content in liver0.10.10.40.60.50.20.30.30.20.4-0.00.0-0.50.5-0.10.3
Mg content in liver0.40.41.1-0.4-0.3-0.7-0.6-0.8-0.9-0.40.8-0.80.5-0.5-1.10.1
Mn content in liver0.60.71.2-0.9-0.6-0.8-0.9-1.0-1.1-0.60.9-0.90.8-0.8-1.00.2
Na content in liver1.01.12.11.51.10.91.11.01.01.0-0.80.8-1.21.21.00.6
Rb content in liver0.10.10.2-0.2-0.4-0.3-0.2-0.2-0.2-0.30.3-0.30.1-0.1-0.4-0.4
Se content in liver5.76.78.5-2.6-2.4-2.7-2.7-2.8-2.9-2.42.7-2.72.6-2.6-2.8-1.4
Sr content in liver0.20.20.4-0.4-0.1-0.4-0.5-0.5-0.6-0.40.5-0.50.4-0.4-0.60.1
Zn content in liver2.42.74.2-1.9-1.1-1.5-1.7-1.8-1.8-1.41.5-1.52.0-2.0-1.7-0.9
Bone: minimum diameter3.46.39.63.12.62.32.72.82.72.5-2.22.2-2.62.62.31.6
Time in familiar zone, hab. session 10.30.30.90.40.60.60.50.30.40.5-0.50.5-0.50.50.80.9
Time in novel zone, hab. session 11.21.22.4-1.0-1.2-1.0-0.9-0.8-0.9-0.91.0-1.01.0-1.0-1.5-1.4
Total zone transitions, hab. session 10.00.10.20.3-0.0-0.0-0.10.10.1-0.40.1-0.1-0.30.30.0-0.5
Total locomotion distance, hab. session 11.31.83.11.71.41.21.31.41.21.0-1.21.2-1.81.81.01.2
Locomotion velocity, hab. session 10.81.12.01.41.20.90.91.00.90.7-0.90.9-1.41.40.91.1
Time in familiar zone, hab. session 21.92.13.71.61.81.11.41.31.21.6-1.11.1-1.61.60.81.9
Time in novel zone, hab. session 21.31.32.1-1.3-1.5-0.8-1.2-1.1-1.0-1.30.8-0.81.2-1.2-0.8-1.3
Total zone transitions, hab. session 22.93.65.0-1.5-1.8-2.0-2.0-1.9-1.9-2.22.0-2.01.7-1.7-2.0-1.9
Total locomotion distance, hab. session 20.10.10.3-0.0-0.1-0.3-0.2-0.1-0.3-0.50.2-0.20.1-0.1-0.5-0.4
Locomotion velocity, hab. session 20.10.20.4-0.2-0.2-0.4-0.4-0.3-0.4-0.70.4-0.40.3-0.3-0.6-0.5
Novel to familiar place preference ratio0.10.10.30.50.30.40.50.50.50.5-0.50.5-0.10.10.00.1
Novelty place preference0.10.10.20.30.20.30.40.40.40.3-0.30.30.0-0.00.0-0.1
Time in novel zone, NPP test0.00.00.10.1-0.00.10.20.20.20.1-0.10.10.2-0.2-0.2-0.4
Total zone transitions, NPP test0.10.10.3-0.4-0.2-0.3-0.4-0.3-0.3-0.60.3-0.30.3-0.3-0.0-0.3
Total locomotion distance, NPP test2.43.34.01.82.01.81.81.81.81.6-1.91.9-1.81.81.81.8
Locomotion velocity, NPP test2.63.74.61.92.11.91.91.91.81.7-2.02.0-2.02.01.82.0
Intraocular pressure0.10.10.30.1-0.4-0.5-0.10.0-0.0-0.30.5-0.5-0.00.0-0.1-0.5
Delta distance traveled before/after self-admin2.12.23.40.61.91.81.51.41.51.8-1.71.7-1.01.01.61.2
Delta ambulatory time before/after self-admin1.82.23.50.31.91.91.51.41.61.8-1.81.8-0.70.71.71.2
Parametrial fat weight0.20.41.0-0.5-0.3-0.1-0.7-1.0-1.0-0.20.5-0.50.8-0.8-0.60.9
Pavlov. Cond. lever latency0.10.10.30.10.20.50.20.20.30.2-0.60.6-0.10.10.50.4
Pavlov. Cond. magazine entry latency0.70.91.2-1.0-1.0-0.9-1.0-1.0-1.1-1.00.8-0.81.0-1.0-0.9-0.5
Pavlov. Cond. change in total contacts0.40.41.0-0.2-0.4-0.8-0.5-0.4-0.5-0.60.8-0.80.2-0.2-0.9-1.0
Pavlov. Cond. index score0.50.60.9-0.6-0.6-0.9-0.8-0.8-0.9-0.70.8-0.80.7-0.7-0.9-0.6
Pavlov. Cond. latency score0.20.30.6-0.3-0.4-0.8-0.5-0.5-0.6-0.50.7-0.70.3-0.3-0.7-0.5
Pavlov. Cond. lever contacts0.10.10.20.40.2-0.30.20.20.10.20.4-0.4-0.30.3-0.2-0.1
Pavlov. Cond. magazine entry number0.50.60.70.70.80.70.80.80.90.8-0.70.7-0.80.80.80.6
Pavlov. Cond. intertrial magazine entries0.81.01.7-0.4-1.0-1.2-1.0-1.0-1.0-1.11.3-1.30.5-0.5-1.1-0.8
Pavlov. Cond. lever-magazine prob. diff.0.70.91.3-0.9-0.9-1.0-1.0-1.0-1.1-0.91.0-1.00.9-0.9-1.1-0.7
Pavlov. Cond. response bias0.30.40.6-0.5-0.6-0.7-0.7-0.7-0.8-0.60.6-0.60.6-0.6-0.7-0.1
Pavlov. Cond. lever latency5.47.38.2-2.8-2.7-2.9-2.8-2.8-2.8-2.92.8-2.82.6-2.6-2.4-2.2
Pavlov. Cond. magazine entry latency3.74.55.52.32.22.12.22.22.12.2-2.12.1-2.22.21.71.9
Pavlov. Cond. change in total contacts7.512.114.13.83.33.53.73.73.73.6-3.53.5-3.53.53.32.5
Pavlov. Cond. index score6.28.39.33.02.93.03.03.02.93.0-3.03.0-2.82.82.62.4
Pavlov. Cond. latency score5.57.28.42.92.72.82.82.82.82.9-2.72.7-2.62.62.32.2
Pavlov. Cond. lever contacts5.87.99.03.02.82.92.92.92.92.9-2.92.9-2.82.82.62.2
Pavlov. Cond. magazine entry number4.55.66.7-2.4-2.2-2.6-2.4-2.3-2.4-2.32.6-2.62.2-2.2-2.3-2.0
Pavlov. Cond. intertrial magazine entries1.32.03.6-1.9-1.1-1.3-1.3-1.3-1.2-1.21.4-1.41.7-1.7-1.1-1.3
Pavlov. Cond. lever-magazine prob. diff.5.87.78.82.92.73.02.92.82.82.9-2.92.9-2.62.62.52.4
Pavlov. Cond. response bias6.99.310.53.23.03.23.23.23.23.1-3.23.2-3.03.02.92.3
Time in closed arm before self-admin1.41.83.7-0.8-1.9-1.4-1.3-1.2-1.2-1.51.4-1.41.0-1.0-1.2-1.8
Time in closed arm after self-admin0.30.31.51.20.20.20.30.60.40.0-0.10.1-1.01.0-0.1-0.0
Time in open arm before self-admin4.34.77.31.52.62.72.12.02.02.5-2.12.1-1.91.91.92.5
Time in open arm after self-admin0.80.81.80.01.21.00.90.60.81.3-1.01.0-0.40.41.11.1
Bone: periosteal estimation2.24.75.42.32.32.32.32.22.22.2-2.12.1-2.02.02.21.9
Bone: periosteal perimeter1.52.55.12.31.51.41.61.61.51.5-1.21.2-1.91.91.31.5
Bone: post-yield work2.13.14.21.81.91.71.92.12.01.8-1.81.8-1.61.61.60.9
Progressive ratio test 1 active lever presses0.10.10.4-0.2-0.0-0.20.00.20.2-0.2-0.10.1-0.30.30.2-0.7
Progressive ratio test 1 breakpoint0.10.10.4-0.10.1-0.10.10.30.3-0.1-0.20.2-0.50.50.2-0.6
Progressive ratio test 1 inactive lever presses0.20.30.80.80.40.10.60.90.80.3-0.00.0-0.70.70.1-0.9
Progressive ratio test 2 active lever presses0.30.31.0-0.6-1.0-0.7-0.6-0.5-0.4-0.80.3-0.30.2-0.2-0.1-0.9
Progressive ratio test 2 breakpoint0.40.51.3-0.7-1.1-0.8-0.7-0.6-0.5-1.00.5-0.50.3-0.3-0.2-1.0
Progressive ratio test 2 inactive lever presses0.40.71.91.30.30.20.71.10.90.3-0.20.2-1.41.40.3-0.5
Incentive Sensitization - Responses0.50.82.0-0.7-1.4-1.1-0.9-0.8-0.7-1.10.8-0.80.5-0.5-0.4-1.1
Incentive Sensitization - Breakpoint0.60.72.0-0.7-1.4-1.0-0.9-0.8-0.7-1.10.7-0.70.6-0.6-0.4-1.1
Sum of active levers in priming session hrs 5-60.10.10.2-0.5-0.4-0.4-0.3-0.2-0.2-0.50.4-0.4-0.00.0-0.1-0.1
Progressive ratio0.00.00.20.10.3-0.1-0.10.0-0.1-0.10.3-0.3-0.20.2-0.40.1
Food seeking constrained by brief footshock2.83.44.51.92.01.91.81.91.81.9-1.61.6-2.12.11.41.8
Seeking ratio, punishment vs. effort0.40.60.80.90.50.90.90.90.90.8-0.80.8-0.70.70.80.4
Retroperitoneal fat weight0.62.64.8-1.6-1.3-1.0-1.8-2.2-2.1-1.31.3-1.32.0-2.0-1.40.8
Reaction time number correct0.00.10.4-0.70.10.1-0.2-0.2-0.1-0.1-0.10.10.5-0.50.2-0.0
Reaction time mean minus median0.20.40.8-0.20.50.90.70.60.70.9-0.80.8-0.20.20.90.5
Reaction time mean minus median AUC0.41.01.8-0.21.01.31.10.91.01.3-1.31.3-0.20.21.30.7
Reaction time num false alarms1.01.53.0-1.3-1.5-1.0-1.1-1.1-1.0-0.91.0-1.01.7-1.7-0.7-1.3
Reaction time num false alarms AUC1.21.83.4-1.5-1.6-1.1-1.3-1.3-1.2-1.01.1-1.11.9-1.9-0.9-1.2
Reaction time trials correct on left0.00.10.4-0.70.10.1-0.2-0.2-0.1-0.1-0.10.10.5-0.50.2-0.0
Reaction time trials on left0.10.10.5-0.70.10.1-0.2-0.2-0.1-0.0-0.10.10.5-0.50.3-0.0
Reaction time mean0.10.20.8-0.40.10.70.40.30.50.4-0.60.60.1-0.10.9-0.0
Reaction time mean AUC0.10.20.6-0.60.00.60.20.20.30.4-0.60.60.2-0.20.80.0
Median of all reaction times0.10.10.4-0.6-0.30.3-0.1-0.10.1-0.0-0.20.20.4-0.40.5-0.3
Reaction time omissions0.20.31.2-1.1-0.2-0.1-0.2-0.3-0.20.3-0.10.10.9-0.90.2-0.0
Reaction time false alarm rate0.70.91.8-0.8-1.4-0.9-0.9-0.9-0.8-0.80.9-0.91.2-1.2-0.8-1.0
Reaction time premature initiation rate0.00.10.2-0.00.50.10.20.30.20.2-0.20.2-0.30.3-0.2-0.2
Reaction time premature initiations0.00.10.3-0.50.50.10.10.20.10.1-0.10.10.1-0.1-0.1-0.3
Std. dev. reaction times0.40.81.9-0.20.61.10.90.81.01.0-1.21.2-0.20.21.40.2
Reaction time trials completed0.10.10.5-0.70.10.1-0.2-0.2-0.1-0.0-0.10.10.5-0.50.3-0.0
Reaction time trials AUC0.10.20.7-0.8-0.00.0-0.3-0.4-0.3-0.20.1-0.10.7-0.70.2-0.0
Run reversals in cocaine runway, females0.60.61.3-0.10.60.80.90.81.00.9-1.01.0-0.10.11.20.2
Run reversals in cocaine runway, males0.30.31.1-0.9-0.10.2-0.5-0.8-0.70.20.0-0.00.3-0.3-0.31.0
Latency to leave start box in cocaine runway0.20.20.9-0.20.50.20.40.50.70.2-0.60.6-0.10.10.9-0.5
Latency to leave start box in cocaine runway, F0.10.10.5-0.70.10.00.10.10.30.1-0.20.20.5-0.50.3-0.7
Latency to leave start box in cocaine runway, M0.10.10.40.30.1-0.20.20.30.3-0.2-0.30.3-0.30.30.7-0.4
Std. dev. time between licks in bursts0.40.61.71.30.90.40.80.90.60.7-0.10.1-1.01.0-0.20.0
Total sessions with >9 infusions1.31.63.7-1.9-1.3-1.3-1.4-1.4-1.3-1.31.0-1.01.3-1.3-0.9-1.0
Short access day 1 total inactive lever presses0.60.81.61.20.80.31.01.31.20.5-0.60.6-1.01.00.7-0.7
Short access day 10 total inactive lever presses1.63.97.82.81.81.42.22.42.21.7-1.21.2-2.62.61.50.6
Short access day 1 total infusions0.00.10.3-0.0-0.1-0.4-0.1-0.0-0.0-0.10.4-0.40.0-0.0-0.1-0.6
Short access day 10 total infusions0.40.51.2-1.1-1.0-0.8-0.8-0.7-0.6-0.80.4-0.40.5-0.5-0.4-0.8
Short access total infusions0.81.11.7-1.3-1.2-1.1-1.1-1.1-1.0-1.10.9-0.91.0-1.0-0.7-1.0
Short access day 1 locomotion1.21.53.3-1.8-0.9-1.0-1.2-1.2-1.1-0.91.0-1.01.6-1.6-0.9-1.2
Short access day 10 total locomotion0.40.71.90.80.90.30.71.00.80.7-0.40.4-1.41.40.20.2
Short access total locomotion1.11.31.9-1.4-1.0-1.2-1.2-1.1-1.1-1.11.1-1.11.0-1.0-1.3-1.2
One hour access (0.3 mA shock)0.50.61.10.60.40.60.81.01.00.6-0.90.9-0.80.80.8-0.5
Compulsive drug intake0.10.10.50.70.3-0.10.40.40.30.20.2-0.20.1-0.1-0.1-0.5
One hour access (shock baseline)0.10.10.3-0.1-0.4-0.0-0.00.10.2-0.3-0.50.5-0.40.40.3-0.6
Social response proportion1.92.23.81.61.51.21.61.71.51.5-1.01.0-2.02.01.01.3
Social responses0.50.71.50.81.20.40.91.00.81.0-0.20.2-1.11.10.20.9
Social time2.53.44.91.61.91.42.02.12.11.9-1.71.7-2.22.21.81.0
Soleus weight0.10.20.5-0.7-0.0-0.2-0.4-0.5-0.4-0.30.2-0.20.7-0.7-0.3-0.0
Bone: stiffness1.52.53.21.61.61.81.61.61.61.5-1.71.7-1.51.51.61.3
Tibialis anterior weight0.10.20.6-0.4-0.3-0.2-0.6-0.7-0.6-0.50.2-0.20.6-0.60.10.2
Time to tail flick, vehicle, before self-admin0.40.40.9-0.9-1.0-0.5-0.6-0.6-0.5-0.40.5-0.50.8-0.8-0.4-0.6
Time to tail flick, vehicle, after self-admin0.60.82.41.60.50.50.60.80.50.5-0.50.5-1.51.5-0.01.2
Time to tail flick, test, before self-admin0.40.41.5-0.7-0.7-0.1-0.1-0.00.2-0.3-0.50.50.9-0.90.5-1.2
Time to tail flick, test, after self-admin0.10.10.3-0.0-0.2-0.2-0.3-0.2-0.3-0.40.5-0.50.3-0.3-0.5-0.1
Delta time to tail flick, vehicle, before/after SA1.01.01.31.11.10.90.91.00.80.9-1.01.0-1.11.10.41.1
Delta time to tail flick, test, before/after SA0.50.51.6-0.00.1-0.5-0.6-0.7-0.9-0.51.1-1.10.1-0.1-1.30.7
Tibia length2.77.510.52.42.63.22.62.62.72.6-3.23.2-2.42.42.82.2
Ambulatory time before self-admin0.30.41.91.40.60.00.50.70.40.10.1-0.1-1.01.00.10.4
Ambulatory time after self-admin4.14.86.31.92.52.42.32.42.32.2-2.12.1-2.02.02.12.1
Bone: tissue strength3.33.34.21.71.92.02.02.02.12.0-1.91.9-1.61.61.70.9
Total heroin consumption0.30.40.70.50.50.40.70.80.80.4-0.60.6-0.60.60.70.1
Bone: trabecular number1.32.23.51.01.51.91.41.41.51.5-1.81.8-1.01.01.71.4
Bone: trabecular spacing0.30.40.80.90.70.40.70.60.50.8-0.40.4-0.70.70.50.9
Bone: trabecular thickness0.10.10.3-0.4-0.40.0-0.3-0.3-0.1-0.4-0.10.10.5-0.50.2-0.5
Bone: trabecular tissue density1.82.64.2-1.6-1.9-1.4-1.9-2.0-2.0-1.81.4-1.41.7-1.7-1.2-0.3
Water consumed over 24 hours0.40.50.80.60.70.90.70.60.70.7-0.90.9-0.60.60.70.8
Number of responses in last shaping day0.10.20.40.60.40.10.30.40.40.1-0.40.4-0.50.50.5-0.1