Hub : Genes

Polr1b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Polr1b 0.23 0.12 0.0e+00 0.13 0.07 0.12 0.13 2.5e-14 7.9e-08 2.0e-13 7.7e-14
2 BLA mRNA stability Polr1b 0.12 0.08 3.8e-05 0.08 0.06 0.07 0.07 5.7e-05 4.1e-04 2.1e-04 8.2e-05
3 pVTA gene expression Polr1b 0.22 0.12 1.6e-14 0.18 0.19 0.17 0.19 1.5e-14 7.0e-15 1.1e-13 3.3e-15
4 IC mRNA stability Polr1b 0.22 0.11 4.9e-08 0.14 0.16 0.16 0.16 1.2e-06 4.2e-07 5.0e-07 3.7e-07
5 Adipose gene expression Polr1b 0.34 0.13 0.0e+00 0.28 0.3 0.29 0.3 2.8e-31 4.9e-33 5.8e-33 7.7e-34
6 pVTA mRNA stability Polr1b 0.09 0.06 8.9e-06 0.05 0.07 0.07 0.06 5.1e-05 5.4e-06 4.9e-06 7.7e-06
7 Brain gene expression Polr1b 0.42 0.16 0.0e+00 0.19 0.22 0.22 0.22 7.3e-18 8.5e-21 3.7e-20 2.6e-20
8 PL mRNA stability Polr1b 0.14 0.07 9.4e-16 0.12 0.14 0.14 0.13 1.5e-13 1.5e-15 8.7e-15 2.1e-14
9 IC gene expression Polr1b 0.2 0.11 8.1e-06 0.08 0.09 0.06 0.06 4.4e-04 2.0e-04 1.9e-03 1.3e-03
10 NAcc gene expression Polr1b 0.24 0.1 0.0e+00 0.16 0.21 0.22 0.21 4.1e-23 2.9e-31 4.1e-32 8.5e-32
11 NAcc mRNA stability Polr1b 0.12 0.07 5.6e-17 0.12 0.11 0.11 0.12 5.9e-17 9.2e-17 9.7e-17 4.4e-17
12 PL gene expression Polr1b 0.42 0.17 0.0e+00 0.14 0.24 0.23 0.24 3.2e-15 2.1e-26 5.2e-25 1.6e-26
13 IL mRNA stability Polr1b 0.16 0.11 9.9e-03 0.06 0.03 0.02 0.02 1.9e-02 8.4e-02 1.2e-01 1.2e-01
14 BLA gene expression Polr1b 0.41 0.16 0.0e+00 0.29 0.34 0.32 0.34 1.7e-15 1.9e-18 9.3e-18 2.0e-18
15 Brain mRNA stability Polr1b 0.07 0.04 5.2e-06 0.03 0.05 0.04 0.04 1.7e-03 1.7e-05 7.0e-05 6.6e-05
16 IL gene expression Polr1b 0.71 0.2 3.2e-05 0.07 0.17 0.16 0.15 1.1e-02 7.1e-05 1.4e-04 1.9e-04
17 Liver mRNA stability Polr1b 0.03 0.03 3.8e-03 0.02 0.02 0.01 0.02 1.8e-03 2.2e-03 1.1e-02 3.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bone: apparent density2.03.54.61.92.12.12.02.02.02.12.01.91.82.21.82.11.71.61.50.6
Area under the delay curve0.30.41.3-0.6-0.6-0.6-0.8-0.7-0.7-0.5-0.5-0.6-0.6-0.7-0.5-1.1-0.5-0.4-0.4-0.1
BMI with tail0.10.31.50.30.0-0.2-0.0-0.2-0.3-0.5-0.4-0.5-0.6-0.1-0.70.4-0.7-0.8-0.7-1.2
BMI without tail0.41.16.92.11.10.61.00.50.0-0.2-0.1-0.3-0.70.6-0.80.9-0.8-1.2-1.0-2.6
Body weight1.04.214.23.83.02.52.72.31.91.71.71.51.22.11.12.31.10.50.7-1.5
Weight adjusted by age3.95.98.02.42.62.62.82.82.82.72.62.52.52.52.32.02.42.22.01.0
Bone surface1.73.14.21.71.91.91.91.81.91.91.91.81.72.11.72.01.71.61.30.8
Bone volume2.03.64.61.72.02.12.02.02.12.12.02.01.92.11.92.01.91.81.50.9
Breakpoint value in progressive ratio session0.40.41.81.00.60.51.00.60.70.20.60.50.30.80.21.30.40.2-0.5-0.5
Number of licking bursts0.20.41.70.40.30.1-0.40.3-0.40.3-0.6-0.6-0.1-0.7-0.2-1.0-0.7-0.71.3-0.7
Context. condit. distance diff. score3.13.87.61.82.12.21.72.21.92.31.81.82.11.32.21.41.81.82.81.3
Locomotion velocity, session 10.10.10.8-0.2-0.3-0.20.1-0.30.1-0.40.20.2-0.10.20.00.60.30.3-0.90.3
Locomotion distance, session 12.12.63.21.41.71.81.61.51.81.71.81.81.71.31.81.31.71.71.41.3
Locomotion velocity, session 20.00.00.2-0.0-0.1-0.1-0.1-0.4-0.1-0.4-0.2-0.2-0.3-0.1-0.10.0-0.1-0.1-0.40.0
Locomotion distance, session 23.44.86.22.22.42.42.52.22.42.12.42.42.12.32.22.32.32.11.11.1
Locomotion velocity, session 30.30.41.90.80.40.10.2-0.3-0.4-0.6-0.4-0.5-0.70.2-0.60.0-0.7-0.9-0.8-1.4
Locomotion distance, session 31.41.56.92.61.91.51.71.10.90.60.80.60.21.40.11.10.2-0.3-0.5-1.8
Stereotopy head waving bouts, day 30.91.15.6-0.9-0.10.30.00.40.70.90.91.01.20.51.30.51.31.61.22.4
Stereotopy head waving duration, day 30.30.41.9-1.4-1.0-0.8-0.9-0.6-0.4-0.4-0.3-0.2-0.1-0.4-0.0-0.10.10.30.01.1
Locomotion velocity, session 71.31.43.61.91.71.61.21.41.01.40.90.91.00.81.11.10.80.61.6-0.1
Locomotion distance, session 74.75.98.42.62.82.82.52.92.52.82.42.32.52.22.51.92.22.02.71.0
Stereotopy head waving bouts, day 71.11.21.8-0.2-0.7-0.9-0.8-1.1-1.2-1.3-1.1-1.2-1.4-0.9-1.3-0.6-1.2-1.3-1.3-1.3
Stereotopy head waving duration, day 71.21.42.4-0.7-1.1-1.2-1.0-1.3-1.3-1.5-1.2-1.2-1.4-1.0-1.3-0.7-1.2-1.2-1.5-1.0
Locomotion velocity, session 81.11.32.51.11.31.31.31.11.31.01.21.21.01.21.21.61.11.10.60.6
Locomotion distance, session 88.211.915.53.53.93.93.63.83.73.73.53.53.53.33.63.43.43.23.11.7
Degree of sensitization distance1.92.06.1-0.10.60.90.51.21.21.71.21.31.70.51.70.71.51.82.52.2
Degree of sensitization stereotypy0.80.93.10.7-0.1-0.3-0.1-0.6-0.7-1.0-0.8-0.8-1.2-0.4-1.1-0.3-1.1-1.3-1.4-1.8
Conditioned locomotion2.12.43.41.61.61.61.81.61.71.41.81.71.51.71.41.81.61.50.60.7
Cocaine response after cond. corrected0.10.10.3-0.10.00.10.10.10.30.20.30.30.40.30.40.10.40.40.30.6
Cocaine response after cond. not corrected0.00.00.2-0.5-0.3-0.2-0.1-0.20.0-0.20.00.10.00.10.0-0.10.10.2-0.30.4
Cocaine response before conditioning0.40.51.2-0.8-0.8-0.8-0.5-0.7-0.7-0.8-0.5-0.5-0.7-0.5-0.7-0.5-0.5-0.5-1.1-0.3
Saline control response2.22.97.12.72.32.02.31.81.71.51.81.71.21.91.22.11.31.00.3-0.5
Bone: connectivity density1.01.52.41.21.41.31.31.31.31.41.31.31.21.61.21.41.21.11.00.5
Bone: cortical apparent density0.60.83.7-0.2-0.6-0.8-0.3-0.7-0.6-1.1-0.6-0.6-1.0-0.4-1.1-0.5-0.8-0.9-1.9-1.2
Bone: cortical area1.82.75.22.32.11.92.21.71.91.41.81.71.22.01.31.71.41.10.4-0.2
Bone: cortical porosity5.35.78.0-1.3-1.9-2.2-2.0-2.6-2.5-2.8-2.5-2.6-2.8-1.9-2.7-1.8-2.7-2.7-2.7-2.3
Bone: cortical porosity2.93.15.0-0.7-1.2-1.5-1.2-1.9-1.8-2.1-1.8-1.9-2.2-1.2-2.1-1.1-2.0-2.1-2.2-2.0
Bone: cortical thickness0.30.41.50.80.60.40.90.40.7-0.00.60.50.11.20.00.70.30.1-1.2-0.7
Bone: cortical thickness0.10.10.70.2-0.0-0.10.1-0.2-0.2-0.4-0.2-0.2-0.50.1-0.4-0.2-0.4-0.4-0.9-0.7
Bone: cortical tissue density0.60.83.5-0.3-0.7-0.9-0.4-0.7-0.7-1.2-0.6-0.7-1.0-0.5-1.1-0.6-0.8-0.9-1.9-1.1
Condit. Reinf. active minus inactive responses0.10.10.80.30.10.00.50.20.2-0.20.20.2-0.00.7-0.20.50.1-0.1-0.9-0.5
Condit. Reinf. active-inactive response ratio0.70.82.00.80.80.81.10.91.10.71.01.00.81.40.71.20.90.7-0.00.2
Condit. Reinf. active responses0.00.00.40.20.10.00.30.10.1-0.20.10.10.00.4-0.20.20.0-0.1-0.6-0.3
Condit. Reinf. inactive responses0.00.10.3-0.00.20.20.10.20.10.20.20.20.3-0.10.3-0.10.30.30.20.5
Incentive salience index mean0.20.30.90.30.40.40.70.70.70.50.60.60.60.90.40.50.60.5-0.10.2
Condit. Reinf. lever presses0.20.30.60.20.50.60.40.70.60.70.50.50.70.60.60.10.50.50.60.4
Condit. Reinf. active minus inactive responses2.63.35.62.42.22.12.22.01.91.82.01.91.61.81.61.81.71.50.90.3
Condit. Reinf. active-inactive response ratio2.83.25.52.32.22.12.12.11.81.91.81.81.61.71.61.71.61.31.40.2
Condit. Reinf. active responses2.43.47.02.72.32.12.51.91.91.62.12.01.51.81.52.21.71.40.3-0.0
Condit. Reinf. inactive responses0.20.30.70.80.60.50.80.40.50.20.60.60.30.60.40.80.50.4-0.40.0
Condit. Reinf. lever presses0.40.62.01.41.11.01.10.90.70.70.80.70.50.50.50.50.50.40.2-0.4
Condit. Reinf. lever reinforcers received2.33.25.92.42.22.12.31.91.81.62.01.91.51.71.51.91.71.40.60.2
Conditioned reinforcement - actives0.20.31.20.3-0.0-0.2-0.2-0.2-0.4-0.2-0.5-0.6-0.5-0.4-0.6-1.0-0.8-0.8-0.3-1.1
Conditioned reinforcement - inactives2.53.65.01.31.61.81.62.12.22.22.12.12.11.92.11.12.12.11.81.6
Conditioned locomotion0.10.20.70.00.0-0.1-0.2-0.2-0.3-0.1-0.4-0.5-0.4-0.3-0.4-0.8-0.6-0.6-0.2-0.8
Patch foraging indifference point 0 sec1.22.13.10.71.21.41.31.31.51.51.61.61.61.31.71.11.71.81.31.7
Patch foraging indifference point AUC0.40.51.21.10.80.81.00.90.90.50.70.70.60.70.50.80.60.40.2-0.2
Delay disc. indifference point, 0s delay2.73.05.9-2.4-2.2-2.1-2.2-2.1-1.8-1.7-1.6-1.6-1.5-1.8-1.4-1.8-1.4-1.1-1.20.1
Delay disc. indifference point, 16s delay0.20.21.2-0.6-0.4-0.3-0.6-0.3-0.4-0.2-0.3-0.3-0.2-0.5-0.2-1.1-0.2-0.10.20.3
Delay disc. indifference point, 2s delay0.10.10.5-0.2-0.2-0.2-0.5-0.3-0.3-0.2-0.3-0.2-0.2-0.4-0.1-0.7-0.2-0.10.20.2
Delay disc. indifference point, 24s delay0.60.72.6-1.1-1.0-0.9-1.2-1.0-0.8-0.6-0.7-0.7-0.6-0.9-0.5-1.6-0.6-0.4-0.40.2
Delay disc. indifference point, 4s delay0.20.20.5-0.0-0.2-0.4-0.4-0.5-0.4-0.5-0.4-0.5-0.6-0.3-0.5-0.4-0.6-0.6-0.7-0.7
Delay disc. indifference point, 8s delay0.50.62.1-0.4-0.6-0.7-0.9-0.7-0.9-0.6-0.8-0.8-0.8-1.0-0.7-1.4-0.9-0.8-0.4-0.5
Indifference point function ln k0.40.71.00.61.01.00.90.70.80.90.90.80.80.90.90.90.80.80.60.4
Indifference point function log k0.40.71.00.61.01.00.90.70.80.90.90.80.80.90.90.90.80.80.60.4
Patch foraging total patch changes 0 sec1.32.43.40.81.31.51.41.41.61.61.71.71.81.51.81.21.81.91.41.8
Patch foraging total patch changes 12 sec0.00.00.20.20.20.20.40.00.2-0.10.20.2-0.00.30.10.40.20.1-0.4-0.0
Patch foraging total patch changes 18 sec0.50.82.6-0.10.40.60.30.60.80.90.70.81.10.21.20.11.01.21.41.6
Patch foraging total patch changes 24 sec1.32.36.3-0.10.71.10.61.31.51.71.21.41.90.71.90.31.71.92.52.4
Patch foraging total patch changes 6 sec1.92.93.51.31.61.81.81.71.91.71.81.81.81.81.81.51.91.81.51.4
Patch foraging time to switch 0 sec3.87.79.9-2.8-2.9-3.0-3.0-3.2-3.1-2.9-3.0-3.0-2.9-2.7-2.8-2.9-2.8-2.7-2.0-1.3
Patch foraging water rate 0 sec4.69.712.43.33.43.43.53.53.43.13.33.33.13.23.03.33.12.82.11.2
Patch foraging water rate 12 sec1.12.43.41.51.81.81.51.81.61.71.51.51.71.21.61.21.51.41.61.0
Patch foraging water rate 18 sec0.10.20.70.80.60.50.50.50.40.40.40.30.30.70.20.40.20.10.1-0.3
Patch foraging water rate 24 sec0.20.31.11.00.90.80.70.70.50.50.40.40.40.70.30.20.30.10.3-0.4
Patch foraging water rate 6 sec1.42.03.61.91.81.71.91.51.51.31.51.41.21.41.21.71.21.00.6-0.1
Seeking ratio, delayed vs. immediate footshock0.10.10.2-0.4-0.4-0.4-0.3-0.2-0.3-0.2-0.3-0.2-0.1-0.4-0.2-0.0-0.1-0.10.00.1
Distance traveled before self-admin4.66.08.12.82.72.72.92.82.72.62.62.52.42.52.22.42.32.11.70.7
Distance traveled after self-admin0.81.02.81.71.31.21.21.31.01.00.80.80.71.00.61.20.60.40.6-0.7
Extensor digitorum longus weight0.00.10.30.50.30.20.10.1-0.10.1-0.3-0.3-0.1-0.3-0.2-0.1-0.3-0.40.4-0.6
Bone: elastic displacement1.41.62.8-0.4-0.9-1.1-0.9-1.2-1.3-1.4-1.3-1.4-1.5-0.9-1.5-0.8-1.5-1.6-1.5-1.7
Bone: elastic work0.60.81.5-0.3-0.6-0.8-0.6-0.9-0.8-1.0-0.9-0.9-1.0-0.6-1.1-0.7-1.0-1.1-1.2-1.2
Bone: endosteal estimation1.43.16.12.12.22.21.81.91.62.11.51.51.61.11.81.41.51.32.50.6
Bone: endosteal perimeter2.65.67.72.82.72.72.72.62.52.52.42.42.22.12.22.52.22.02.00.7
Epididymis fat weight0.20.81.2-0.8-1.0-1.0-1.1-0.8-1.0-0.9-1.0-1.0-0.8-0.9-0.9-0.8-0.9-0.9-0.4-0.4
Delta time in closed arm before/after self-admin0.40.40.7-0.5-0.5-0.5-0.7-0.7-0.6-0.5-0.7-0.7-0.6-0.8-0.5-0.8-0.7-0.6-0.1-0.3
Delta time in open arm before/after self-admin1.71.73.40.81.01.11.31.21.51.21.41.51.41.41.31.81.51.40.91.0
Diff in mean of infusions in LGA sessions0.10.20.7-0.2-0.8-0.7-0.5-0.6-0.3-0.6-0.4-0.2-0.4-0.4-0.40.1-0.1-0.2-0.20.0
Delay discount exponential model param0.30.41.20.50.50.60.80.70.70.50.50.60.60.70.51.10.60.40.50.2
Extinction: sum of active levers before priming0.20.21.20.2-0.1-0.20.2-0.3-0.1-0.7-0.2-0.2-0.50.2-0.50.8-0.3-0.4-1.1-0.6
Active lever presses in extinction session 60.10.10.6-0.1-0.00.10.20.10.20.30.40.40.30.20.40.70.50.50.20.6
Bone: final force1.93.05.92.42.32.12.21.81.91.61.81.71.32.01.41.71.41.20.7-0.1
Bone: final moment1.52.44.72.22.11.92.01.61.71.51.61.51.21.81.31.51.31.00.8-0.1
Food consumed during 24 hour testing period0.10.20.8-0.6-0.3-0.1-0.30.00.10.40.00.10.5-0.20.4-0.20.20.40.90.9
Glucose0.20.40.70.50.70.70.60.70.60.70.60.60.60.50.60.80.50.50.60.2
Heart weight8.112.615.53.53.93.93.93.93.93.83.73.73.53.83.53.63.53.22.81.5
Delay discount hyperbolic model param0.30.31.10.50.50.50.80.60.60.50.50.50.50.70.41.00.50.40.30.1
Intermittent access intake day 1-15 change0.00.10.70.30.30.10.10.3-0.10.1-0.0-0.1-0.10.3-0.30.1-0.3-0.4-0.3-0.9
Intermittent access intake escalation0.10.21.20.30.1-0.1-0.00.1-0.2-0.0-0.2-0.3-0.30.1-0.5-0.2-0.5-0.6-0.4-1.1
Intermittent access intake escalation 20.20.21.10.10.0-0.2-0.0-0.0-0.3-0.2-0.2-0.4-0.4-0.0-0.6-0.0-0.5-0.6-0.7-1.0
Intermitt. access day 1 inactive lever presses0.62.13.01.51.71.61.51.71.71.71.61.51.41.61.40.91.41.31.10.4
Intermitt. access day 15 inactive lever presses2.24.68.31.11.82.11.62.22.22.62.22.22.51.62.50.92.32.42.92.3
Intermitt. access escalation Index0.10.10.60.50.30.20.30.20.0-0.2-0.0-0.1-0.20.4-0.30.4-0.2-0.4-0.5-0.8
Intermittent access day 1 total infusions0.10.11.00.10.10.0-0.20.1-0.00.1-0.1-0.2-0.1-0.1-0.1-1.0-0.2-0.20.2-0.3
Intermittent access day 15 total infusions0.10.20.60.70.70.60.40.80.40.70.30.20.40.50.2-0.30.10.00.4-0.5
Intermittent access terminal intake (last 3 days)0.40.51.10.70.80.80.71.10.81.00.80.70.80.80.60.20.50.50.7-0.0
Intermittent access total infusions0.50.61.20.91.00.90.81.10.91.10.80.70.90.80.70.00.60.60.80.1
Intermittent access day 1 locomotion0.50.71.50.91.11.00.81.10.91.20.80.70.80.70.8-0.30.60.61.10.1
Intermittent access day 15 total locomotion0.91.72.60.71.01.11.11.51.51.61.61.51.51.51.40.81.41.51.01.0
Intermittent access total locomotion1.31.62.81.31.51.41.31.61.41.71.41.21.31.41.20.51.11.11.20.2
Intermittent access standard deviation0.10.30.70.50.70.70.60.90.50.70.50.40.60.50.40.50.30.30.6-0.2
Left kidney weight1.57.010.51.22.02.41.92.52.72.92.72.83.12.03.12.03.03.13.23.2
Right kidney weight1.46.69.81.22.02.32.02.32.62.82.52.72.92.03.02.32.93.03.13.0
Cocaine induced anxiety0.81.24.2-2.1-1.5-1.1-1.6-1.0-0.6-0.4-0.7-0.5-0.1-1.2-0.1-1.5-0.10.20.71.7
Post-drug Anxiety0.70.82.6-1.6-1.3-1.0-1.4-0.8-0.6-0.4-0.7-0.5-0.2-1.0-0.2-1.2-0.20.00.51.2
Baseline Anxiety0.10.10.40.40.20.10.20.1-0.1-0.1-0.1-0.1-0.10.1-0.20.3-0.2-0.3-0.3-0.7
Tail length1.86.917.44.23.73.33.43.02.72.62.42.32.12.72.12.51.91.41.7-0.6
Length with tail3.615.730.25.55.14.84.84.54.24.04.03.83.54.23.43.83.32.72.50.1
Length without tail2.47.910.23.03.23.23.13.03.12.93.02.92.82.92.72.62.82.52.01.2
Times rat made contact with spout0.00.00.2-0.1-0.2-0.2-0.20.1-0.00.0-0.0-0.00.10.10.00.50.00.10.20.2
Lifetime Intake0.60.71.20.91.00.90.81.10.91.10.90.80.90.90.80.10.70.70.90.1
Liver weight, left1.32.13.01.71.71.71.61.51.51.61.41.41.41.21.51.01.41.21.60.6
Liver weight, right0.20.30.50.60.60.60.60.70.60.60.60.60.60.50.40.30.50.40.40.1
Locomotor activity0.20.30.70.70.80.70.80.50.50.20.50.40.20.80.20.50.30.1-0.4-0.4
Locomotor testing distance0.20.30.50.10.60.70.50.50.60.60.60.60.70.70.70.20.70.70.50.6
Locomotor testing rearing1.32.53.21.21.71.81.71.61.71.61.71.71.71.81.71.31.71.61.21.2
Locomotion in novel chamber0.10.21.10.70.50.30.30.30.10.2-0.1-0.2-0.10.1-0.30.1-0.4-0.5-0.0-1.1
Locomotion in novel chamber post-restriction0.20.42.00.70.3-0.00.3-0.1-0.2-0.5-0.2-0.3-0.60.1-0.60.7-0.5-0.7-1.0-1.4
Fecal boli incidents, locomotor time 10.40.61.0-0.3-0.7-0.8-0.5-0.8-0.9-1.0-0.8-0.8-0.9-0.7-1.00.0-0.9-0.9-1.0-0.7
Change in fecal boli incidents, locomotor task0.00.00.2-0.5-0.2-0.2-0.1-0.20.1-0.00.10.0-0.00.10.00.10.00.1-0.30.2
Time >=10cm from walls, locomotor time 10.30.31.50.50.3-0.1-0.2-0.4-0.5-0.4-0.5-0.6-0.7-0.4-0.6-0.4-0.8-0.9-0.5-1.2
Bouts of movement, locomotor time 13.54.07.1-2.5-2.7-2.5-2.2-2.3-1.8-2.2-1.8-1.7-1.9-1.8-1.8-2.1-1.6-1.3-2.1-0.4
Total resting periods, locomotor time 13.84.37.2-2.4-2.7-2.5-2.2-2.4-1.8-2.4-1.9-1.8-2.1-1.8-2.0-2.1-1.7-1.5-2.3-0.7
Rest time, locomotor task time 10.81.01.4-0.8-1.2-1.1-1.0-1.1-0.8-1.1-1.0-1.0-1.1-0.9-1.0-1.0-0.9-0.9-1.0-0.7
Distance moved, locomotor task time 10.00.00.1-0.00.30.20.10.1-0.00.20.00.10.20.10.20.10.10.10.30.2
Vertical activity count, locomotor time 10.20.40.80.50.80.80.60.70.50.80.60.60.60.50.70.80.50.50.90.4
Time >=10cm from walls, locomotor time 20.10.10.50.50.50.3-0.10.1-0.30.2-0.2-0.3-0.1-0.3-0.0-0.7-0.3-0.30.6-0.4
Bouts of movement, locomotor time 21.52.43.4-1.1-1.3-1.4-1.6-1.5-1.7-1.5-1.6-1.7-1.7-1.5-1.6-1.8-1.7-1.6-1.3-1.3
Total resting periods, locomotor time 21.62.73.5-1.1-1.4-1.5-1.6-1.6-1.8-1.7-1.7-1.8-1.8-1.5-1.8-1.9-1.9-1.8-1.6-1.5
Rest time, locomotor task time 21.31.74.0-1.0-1.4-1.4-1.0-1.3-1.1-1.6-1.2-1.2-1.4-0.8-1.5-0.9-1.2-1.2-2.0-1.2
Distance moved, locomotor task time 20.70.82.00.20.80.80.50.70.81.00.70.81.00.51.10.31.01.01.41.3
Vertical activity count, locomotor time 20.91.32.90.71.11.20.71.00.91.31.01.11.20.81.41.11.21.21.71.2
Light reinforcement 10.20.41.81.31.00.91.00.70.50.60.60.60.50.50.50.50.40.30.4-0.2
Light reinforcement 20.10.20.60.80.60.50.60.60.40.50.40.40.40.40.40.10.30.20.6-0.1
Bone: marrow area1.43.16.02.12.22.21.81.91.62.11.51.61.61.11.81.41.51.42.40.7
Bone: maximum diameter3.36.210.63.33.02.93.12.62.72.42.62.62.12.72.22.62.32.01.40.4
Bone: maximum force0.81.52.11.31.51.41.51.31.41.21.31.31.11.31.21.11.11.00.80.3
Bone: maximum moment0.51.01.41.01.21.21.11.01.11.01.01.00.91.01.00.70.90.90.80.4
Mean time between licks in bursts0.30.71.0-0.4-0.7-0.8-0.7-0.9-0.9-0.9-0.9-0.9-1.0-0.6-0.9-0.6-0.9-0.9-0.8-0.7
Mean num. licks in bursts0.30.51.7-0.4-0.2-0.00.40.00.70.00.80.90.50.90.51.31.01.0-0.81.1
Cd content in liver0.70.72.51.61.20.91.21.10.70.60.70.60.41.30.30.80.40.1-0.2-0.8
Co content in liver0.60.72.91.71.20.91.10.80.50.40.60.50.20.70.21.40.2-0.0-0.3-1.0
Cu content in liver0.81.03.41.91.41.11.41.10.80.70.90.80.50.90.41.40.50.2-0.2-0.9
Fe content in liver0.10.10.40.70.40.30.30.2-0.00.10.10.1-0.1-0.10.0-0.1-0.1-0.1-0.0-0.4
K content in liver0.40.40.70.80.70.70.80.60.70.50.70.70.60.80.50.60.60.50.0-0.0
Mg content in liver0.90.93.21.81.31.11.31.00.90.60.90.80.51.10.41.40.50.3-0.3-0.8
Mn content in liver1.41.63.92.01.71.61.71.21.31.11.31.20.91.40.91.41.00.70.3-0.4
Na content in liver0.10.10.6-0.2-0.10.1-0.1-0.00.10.30.10.20.3-0.20.4-0.30.30.40.80.8
Rb content in liver1.82.16.61.91.61.41.81.61.41.01.51.41.11.80.92.61.20.9-0.1-0.3
Se content in liver1.11.22.41.51.51.41.41.41.11.11.21.21.01.00.90.91.00.80.5-0.0
Sr content in liver0.50.41.31.11.00.90.60.70.50.80.40.30.50.40.50.20.30.21.1-0.3
Zn content in liver0.20.20.50.70.50.40.60.50.40.10.40.30.10.5-0.00.40.1-0.0-0.6-0.7
Bone: minimum diameter0.91.63.51.91.71.61.71.21.41.21.31.20.91.41.11.31.10.90.6-0.0
Time in familiar zone, hab. session 10.60.61.0-0.7-0.8-0.7-0.9-0.8-0.9-0.7-0.9-0.9-0.8-1.0-0.7-0.9-0.8-0.7-0.2-0.3
Time in novel zone, hab. session 11.41.42.00.80.91.01.11.31.31.31.31.41.41.21.21.31.41.40.91.1
Total zone transitions, hab. session 11.52.12.71.61.61.61.51.51.61.51.61.51.51.11.51.21.51.41.10.9
Total locomotion distance, hab. session 13.24.56.01.82.22.32.02.12.22.32.22.32.31.52.41.62.32.32.21.9
Locomotion velocity, hab. session 13.14.55.81.72.22.32.02.12.32.32.22.32.21.72.41.52.32.32.11.8
Time in familiar zone, hab. session 20.40.41.3-1.1-0.9-0.8-0.8-0.7-0.5-0.5-0.5-0.5-0.3-0.6-0.4-0.8-0.3-0.2-0.20.4
Time in novel zone, hab. session 20.30.31.41.20.90.80.80.60.40.40.40.40.20.60.30.80.20.10.2-0.5
Total zone transitions, hab. session 21.31.64.72.21.81.61.71.41.31.11.31.20.91.10.91.20.90.70.3-0.4
Total locomotion distance, hab. session 24.66.07.51.82.42.62.52.52.72.62.72.72.72.12.72.22.72.71.92.0
Locomotion velocity, hab. session 24.35.87.81.42.12.42.32.32.62.52.72.72.72.02.72.02.82.81.92.3
Novel to familiar place preference ratio0.40.41.20.10.40.50.30.60.50.70.50.60.80.30.80.20.70.81.11.0
Novelty place preference0.20.20.8-0.10.10.30.00.30.20.40.20.30.50.10.6-0.00.40.50.90.8
Time in novel zone, NPP test0.20.20.90.00.20.40.10.40.30.50.30.40.60.10.60.10.50.60.90.8
Total zone transitions, NPP test0.30.51.41.21.00.90.80.80.80.70.60.60.50.40.60.30.50.40.6-0.1
Total locomotion distance, NPP test4.86.68.61.92.52.72.42.72.82.92.72.72.82.02.91.92.82.82.72.1
Locomotion velocity, NPP test3.75.27.01.62.22.42.02.42.52.72.42.42.61.72.61.52.52.52.62.1
Intraocular pressure0.20.31.00.40.1-0.1-0.3-0.4-0.5-0.4-0.6-0.6-0.7-0.6-0.6-0.3-0.7-0.8-0.1-1.0
Delta distance traveled before/after self-admin1.21.31.9-0.5-1.0-1.1-1.0-1.1-1.2-1.4-1.3-1.3-1.3-0.9-1.3-0.3-1.3-1.4-1.1-1.3
Delta ambulatory time before/after self-admin3.34.05.1-1.9-2.1-2.2-2.2-2.2-2.3-2.3-2.3-2.2-2.1-2.0-2.0-1.5-2.0-2.0-1.4-1.1
Parametrial fat weight0.61.42.3-0.9-1.3-1.3-1.3-1.1-1.1-1.2-1.3-1.3-1.1-1.0-1.3-1.5-1.3-1.2-0.8-0.8
Pavlov. Cond. lever latency0.50.71.80.3-0.4-0.6-0.5-0.7-0.8-0.9-0.8-0.9-1.0-0.6-1.0-0.5-1.0-1.1-0.8-1.3
Pavlov. Cond. magazine entry latency0.70.91.50.61.01.01.01.21.11.01.11.11.11.01.00.81.11.00.60.6
Pavlov. Cond. change in total contacts0.70.71.10.40.70.80.71.00.91.00.80.91.10.60.90.40.90.91.00.9
Pavlov. Cond. index score0.40.60.90.00.50.60.60.90.90.80.80.80.90.60.80.50.90.90.60.9
Pavlov. Cond. latency score0.70.91.9-0.10.50.70.71.01.11.01.11.11.20.71.10.61.21.30.81.4
Pavlov. Cond. lever contacts0.70.81.5-0.00.60.70.70.91.01.01.01.01.10.81.00.61.11.10.81.2
Pavlov. Cond. magazine entry number0.10.10.4-0.5-0.5-0.5-0.5-0.6-0.4-0.3-0.3-0.3-0.3-0.3-0.2-0.2-0.2-0.10.00.3
Pavlov. Cond. intertrial magazine entries0.10.10.30.60.40.30.40.20.30.20.20.20.10.60.10.50.10.0-0.0-0.3
Pavlov. Cond. lever-magazine prob. diff.0.20.30.5-0.10.30.40.40.70.60.60.60.60.70.50.60.40.70.70.40.7
Pavlov. Cond. response bias0.30.40.70.50.80.70.70.90.70.60.60.60.60.60.50.60.50.40.40.1
Pavlov. Cond. lever latency1.52.05.1-2.3-1.9-1.8-1.9-1.7-1.4-1.3-1.4-1.4-1.1-1.3-1.0-1.2-1.1-0.8-0.50.4
Pavlov. Cond. magazine entry latency0.20.30.60.10.40.50.30.50.50.60.50.50.60.30.60.10.50.60.80.6
Pavlov. Cond. change in total contacts0.40.72.51.61.21.11.20.90.80.60.80.80.40.90.40.70.50.3-0.0-0.6
Pavlov. Cond. index score0.81.02.81.71.51.31.41.21.00.91.00.90.71.00.70.80.70.50.4-0.4
Pavlov. Cond. latency score0.71.02.11.51.41.31.31.11.01.01.01.00.81.00.80.70.80.60.5-0.1
Pavlov. Cond. lever contacts1.52.14.92.22.01.81.91.81.41.41.51.41.21.31.11.21.20.90.7-0.2
Pavlov. Cond. magazine entry number0.20.20.6-0.8-0.8-0.7-0.6-0.6-0.5-0.5-0.4-0.4-0.4-0.5-0.3-0.2-0.3-0.2-0.30.2
Pavlov. Cond. intertrial magazine entries0.10.21.20.10.20.2-0.00.40.20.60.10.20.4-0.20.4-0.20.20.31.10.5
Pavlov. Cond. lever-magazine prob. diff.0.60.71.91.41.21.11.21.00.80.80.90.80.60.90.60.70.60.50.2-0.3
Pavlov. Cond. response bias1.52.14.72.22.01.81.91.81.41.41.51.41.21.31.11.21.10.90.8-0.3
Time in closed arm before self-admin1.11.42.1-1.0-1.1-1.2-1.2-1.2-1.5-1.3-1.4-1.3-1.3-1.4-1.1-1.1-1.3-1.2-0.7-0.6
Time in closed arm after self-admin3.43.64.9-1.5-1.7-1.8-1.9-2.0-2.2-2.1-2.2-2.1-2.1-2.2-1.9-1.8-2.1-2.0-1.3-1.2
Time in open arm before self-admin0.20.20.60.0-0.2-0.3-0.4-0.3-0.3-0.3-0.4-0.5-0.4-0.3-0.5-0.6-0.6-0.6-0.4-0.8
Time in open arm after self-admin2.73.04.21.21.51.61.71.72.11.92.01.91.91.91.81.51.91.91.31.2
Bone: periosteal estimation1.73.66.82.62.52.42.32.02.02.01.81.81.51.81.71.81.61.31.50.1
Bone: periosteal perimeter2.95.06.52.42.42.42.62.42.42.32.42.32.12.32.12.52.22.01.50.8
Bone: post-yield work0.20.21.0-1.0-0.5-0.3-0.7-0.5-0.3-0.1-0.4-0.3-0.1-0.60.0-0.7-0.10.10.50.8
Progressive ratio test 1 active lever presses1.11.43.11.81.51.31.61.41.31.21.21.10.91.40.81.00.80.70.4-0.5
Progressive ratio test 1 breakpoint1.21.53.41.81.61.41.61.51.31.21.31.11.01.50.81.10.90.70.4-0.5
Progressive ratio test 1 inactive lever presses0.91.31.91.21.21.21.21.31.41.31.41.31.11.31.10.61.11.10.60.4
Progressive ratio test 2 active lever presses0.60.71.10.90.90.90.91.01.01.00.90.90.91.00.80.40.80.80.50.2
Progressive ratio test 2 breakpoint0.70.81.21.00.90.91.01.11.01.01.00.90.91.10.80.50.80.80.50.2
Progressive ratio test 2 inactive lever presses2.64.35.91.82.12.22.02.32.32.42.32.22.22.12.11.52.12.01.91.2
Incentive Sensitization - Responses0.00.00.10.1-0.1-0.1-0.1-0.1-0.0-0.2-0.0-0.1-0.2-0.0-0.2-0.2-0.1-0.1-0.4-0.2
Incentive Sensitization - Breakpoint0.00.00.1-0.1-0.2-0.2-0.2-0.2-0.1-0.2-0.1-0.1-0.2-0.1-0.2-0.3-0.1-0.1-0.3-0.0
Sum of active levers in priming session hrs 5-61.31.22.00.80.91.01.11.01.01.11.11.21.11.11.21.41.21.11.10.9
Progressive ratio2.74.210.3-3.2-2.8-2.5-2.7-2.4-2.0-1.8-2.0-1.9-1.6-2.3-1.4-2.3-1.5-1.1-0.60.6
Food seeking constrained by brief footshock2.12.64.00.51.01.41.41.41.71.61.81.81.71.61.81.91.92.01.31.8
Seeking ratio, punishment vs. effort4.15.98.72.92.92.83.02.62.52.32.62.52.22.82.12.72.32.01.10.5
Retroperitoneal fat weight0.10.52.5-0.9-0.5-0.4-1.0-0.2-0.50.2-0.5-0.50.1-0.60.0-1.6-0.3-0.01.30.8
Reaction time number correct0.30.60.80.40.60.70.60.60.80.80.80.80.80.60.80.70.90.90.80.9
Reaction time mean minus median0.10.31.5-1.2-0.8-0.7-0.8-0.5-0.4-0.3-0.4-0.4-0.2-0.6-0.2-0.5-0.2-0.00.20.7
Reaction time mean minus median AUC0.00.10.6-0.8-0.4-0.3-0.4-0.10.00.10.00.10.20.10.2-0.10.20.30.30.7
Reaction time num false alarms3.34.66.12.12.42.52.52.42.22.22.32.32.12.12.12.32.12.01.41.1
Reaction time num false alarms AUC1.92.94.51.92.12.02.11.91.71.61.91.81.61.71.61.91.71.50.80.6
Reaction time trials correct on left0.30.60.80.40.60.70.60.60.80.80.80.80.80.60.80.70.90.90.80.9
Reaction time trials on left0.30.60.80.50.60.80.70.70.80.80.80.90.80.70.90.80.90.90.80.9
Reaction time mean0.00.00.00.00.10.00.00.20.00.10.0-0.00.00.1-0.0-0.0-0.0-0.1-0.1-0.2
Reaction time mean AUC0.00.00.00.00.10.00.00.10.00.10.0-0.00.00.1-0.0-0.0-0.0-0.0-0.0-0.2
Median of all reaction times0.00.10.20.40.40.30.30.40.20.20.20.20.20.30.10.20.10.0-0.0-0.3
Reaction time omissions1.01.42.91.01.11.11.41.31.31.11.51.41.21.71.01.31.31.2-0.00.5
Reaction time false alarm rate1.21.72.91.41.61.51.71.41.31.11.41.41.21.41.11.51.21.10.30.3
Reaction time premature initiation rate0.10.10.50.60.30.1-0.00.1-0.2-0.0-0.3-0.3-0.3-0.3-0.3-0.4-0.4-0.50.2-0.7
Reaction time premature initiations0.00.10.30.50.30.30.10.20.10.3-0.0-0.00.1-0.10.1-0.1-0.0-0.00.5-0.1
Std. dev. reaction times0.00.00.10.10.20.10.10.30.10.10.10.10.10.30.00.10.0-0.0-0.1-0.3
Reaction time trials completed0.30.60.80.50.60.80.70.70.80.80.80.90.80.70.90.80.90.90.80.9
Reaction time trials AUC0.30.60.80.50.60.70.60.60.80.80.80.80.80.70.90.80.90.90.80.9
Run reversals in cocaine runway, females0.90.91.60.81.11.10.71.10.91.20.90.81.10.71.00.20.80.81.30.5
Run reversals in cocaine runway, males1.31.32.41.41.21.11.41.21.20.91.31.30.81.50.91.31.10.9-0.1-0.2
Latency to leave start box in cocaine runway0.80.91.3-1.1-1.1-1.1-1.1-1.1-1.0-1.1-0.9-0.8-0.9-0.9-0.8-1.1-0.7-0.6-0.9-0.1
Latency to leave start box in cocaine runway, F3.43.95.8-2.0-2.2-2.2-2.0-2.2-2.0-2.4-2.0-2.0-2.1-1.8-2.0-1.5-1.8-1.8-2.2-1.0
Latency to leave start box in cocaine runway, M0.60.61.00.80.70.80.70.80.70.90.70.80.80.60.8-0.20.80.81.00.6
Std. dev. time between licks in bursts0.40.61.21.11.11.00.91.00.70.90.60.60.60.50.60.90.50.40.8-0.2
Total sessions with >9 infusions0.00.00.30.30.0-0.10.00.10.00.0-0.1-0.1-0.10.1-0.2-0.3-0.2-0.2-0.1-0.6
Short access day 1 total inactive lever presses0.60.72.20.00.70.80.20.90.81.40.80.71.00.51.1-0.50.70.91.51.0
Short access day 10 total inactive lever presses0.10.20.8-0.6-0.10.1-0.4-0.10.00.40.00.00.3-0.30.4-0.80.20.40.90.9
Short access day 1 total infusions0.40.50.90.40.60.60.40.70.80.90.70.70.80.50.80.10.70.80.90.7
Short access day 10 total infusions0.10.10.7-0.0-0.1-0.1-0.20.0-0.20.0-0.2-0.3-0.1-0.2-0.2-0.8-0.3-0.30.1-0.3
Short access total infusions0.10.10.30.50.40.40.20.50.40.50.30.20.40.30.3-0.30.20.20.5-0.1
Short access day 1 locomotion0.50.61.50.00.50.60.30.80.81.10.70.70.90.51.00.10.80.91.21.0
Short access day 10 total locomotion0.50.91.60.70.91.00.91.11.01.21.11.01.01.01.00.50.91.00.90.6
Short access total locomotion0.91.11.80.71.01.01.01.21.21.41.21.11.21.01.10.51.01.11.00.6
One hour access (0.3 mA shock)0.20.20.40.50.40.40.50.60.50.50.50.40.40.60.3-0.10.30.30.1-0.1
Compulsive drug intake0.10.10.4-0.5-0.4-0.3-0.3-0.3-0.2-0.0-0.1-0.2-0.2-0.3-0.1-0.7-0.20.0-0.00.2
One hour access (shock baseline)0.00.10.20.40.20.20.30.30.20.10.20.20.10.30.00.30.1-0.0-0.2-0.4
Social response proportion1.01.11.50.90.91.01.20.91.20.91.21.21.01.21.11.21.21.10.50.7
Social responses1.11.43.61.71.31.21.70.91.20.51.21.20.51.70.61.91.00.7-0.6-0.4
Social time0.10.10.50.40.20.20.40.00.3-0.00.40.30.00.10.00.70.20.2-0.7-0.2
Soleus weight0.61.73.41.21.41.51.21.41.31.61.21.31.40.61.50.91.31.31.80.9
Bone: stiffness1.52.43.61.81.81.71.91.61.81.41.71.71.41.71.51.71.61.40.60.5
Tibialis anterior weight0.62.15.92.42.11.82.01.71.41.31.31.21.01.30.91.60.90.60.6-0.7
Time to tail flick, vehicle, before self-admin0.50.52.7-0.50.10.3-0.20.40.40.80.20.30.8-0.40.8-0.80.50.71.61.2
Time to tail flick, vehicle, after self-admin0.81.12.0-1.0-1.2-1.1-1.2-1.0-1.2-0.9-1.3-1.3-1.0-1.4-1.0-0.4-1.2-1.10.0-0.7
Time to tail flick, test, before self-admin0.30.32.10.60.1-0.20.1-0.2-0.2-0.5-0.3-0.4-0.60.2-0.7-0.3-0.6-0.7-1.0-1.4
Time to tail flick, test, after self-admin0.10.10.9-0.6-0.2-0.0-0.1-0.10.10.20.20.30.30.10.40.20.40.60.30.9
Delta time to tail flick, vehicle, before/after SA0.40.42.10.90.40.20.50.10.0-0.3-0.0-0.1-0.40.4-0.41.5-0.3-0.5-0.7-1.1
Delta time to tail flick, test, before/after SA0.70.73.3-0.50.10.40.10.50.40.80.60.70.90.21.10.21.01.11.41.8
Tibia length0.61.89.52.71.50.91.40.30.2-0.30.0-0.2-0.90.7-0.81.4-0.7-1.2-1.5-3.1
Ambulatory time before self-admin1.92.95.32.32.01.92.12.11.91.81.81.71.61.71.41.61.41.21.1-0.0
Ambulatory time after self-admin0.30.31.51.10.60.40.60.50.2-0.00.00.0-0.10.3-0.21.2-0.2-0.4-0.2-1.2
Bone: tissue strength0.80.81.00.40.80.80.70.91.01.00.90.91.00.91.00.51.01.00.90.8
Total heroin consumption1.82.14.91.61.21.21.81.31.71.01.71.71.21.81.22.21.61.40.10.6
Bone: trabecular number2.74.46.52.42.62.52.32.22.22.32.12.11.92.22.02.21.81.71.80.5
Bone: trabecular spacing0.40.51.0-0.9-1.0-0.9-0.8-0.6-0.7-0.9-0.6-0.6-0.5-0.9-0.7-0.8-0.5-0.5-0.9-0.1
Bone: trabecular thickness1.11.32.91.21.21.21.31.21.31.11.31.21.01.71.01.41.11.00.40.4
Bone: trabecular tissue density1.31.93.01.31.31.31.61.61.61.21.61.51.41.71.11.71.41.30.20.4
Water consumed over 24 hours0.10.10.3-0.2-0.2-0.3-0.4-0.2-0.3-0.1-0.4-0.5-0.3-0.3-0.4-0.2-0.5-0.50.1-0.5
Number of responses in last shaping day0.20.20.40.50.60.60.40.50.40.50.40.40.40.30.40.10.30.30.50.1