Hub : Genes

Poglut2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	mRNA stability	Poglut2	0.22	0.16	8.6e-03	0.03	-0.01	0.05	-0.01	5.4e-02	8.7e-01	2.9e-02	5.7e-01
2	Adipose	gene expression	Poglut2	0.04	0.03	4.7e-05	0.02	0.02	0.01	0.02	2.1e-03	2.8e-03	7.4e-03	4.9e-03
3	PL	gene expression	Poglut2	0.02	0.02	2.2e-03	0.02	0.02	0.02	0.02	1.2e-03	1.2e-03	1.2e-03	1.6e-03
4	Liver	mRNA stability	Poglut2	0.05	0.04	2.4e-05	0.02	0.01	0	0.01	4.2e-03	8.7e-03	8.9e-02	1.3e-02
5	Liver	gene expression	Poglut2	0.03	0.02	1.4e-03	0.01	0	0	0	6.0e-02	1.9e-01	3.6e-01	3.0e-01
6	IL	mRNA stability	Poglut2	0.15	0.11	6.7e-03	0.05	0	0.01	-0.01	2.2e-02	3.0e-01	1.4e-01	4.8e-01
7	NAcc	alternative TSS	XM_063267166.1	0.08	0.06	5.2e-03	0.02	0	0.01	0.01	1.3e-03	6.9e-02	2.0e-02	6.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	4.7	8.1	9.8	2.6	-3.1	3.1	3.1	-3.1	3.1	1.0
Area under the delay curve	0.6	0.7	2.6	0.1	0.7	-0.6	-0.8	0.7	-0.8	-1.6
BMI with tail	1.6	5.6	9.1	-3.0	2.3	-2.3	-2.6	2.5	-2.5	0.6
BMI without tail	0.1	0.4	0.7	-0.7	0.5	-0.5	-0.8	0.8	-0.8	-0.2
Body weight	0.1	0.4	0.7	-0.5	0.8	-0.7	-0.4	0.4	-0.5	-0.9
Weight adjusted by age	0.6	0.9	3.1	-1.0	0.5	-0.6	-0.7	0.8	-0.8	1.8
Bone surface	0.4	0.7	2.3	0.2	-0.8	0.8	0.7	-0.8	0.7	1.5
Bone volume	2.0	3.5	4.2	1.4	-2.0	2.0	2.0	-2.0	2.0	1.4
Breakpoint value in progressive ratio session	0.5	0.7	1.3	1.1	-0.8	0.8	0.9	-0.7	0.8	-0.4
Number of licking bursts	0.1	0.2	0.4	0.5	-0.4	0.4	0.6	-0.4	0.6	-0.0
Context. condit. distance diff. score	1.5	1.9	2.9	1.7	-1.2	1.2	1.3	-1.5	1.4	-1.1
Locomotion velocity, session 1	0.5	0.5	3.0	0.7	0.1	-0.1	0.0	0.2	-0.1	-1.7
Locomotion distance, session 1	1.2	1.5	2.3	-0.5	1.1	-1.1	-1.2	1.5	-1.4	-1.5
Locomotion velocity, session 2	4.0	4.6	6.1	-2.5	2.1	-2.2	-2.3	2.4	-2.3	0.2
Locomotion distance, session 2	3.5	4.9	6.5	-2.4	2.4	-2.3	-2.3	2.5	-2.4	-0.2
Locomotion velocity, session 3	0.1	0.2	0.3	0.5	-0.3	0.4	0.4	-0.4	0.4	-0.2
Locomotion distance, session 3	0.1	0.1	0.2	0.5	-0.3	0.4	0.4	-0.4	0.4	0.0
Stereotopy head waving bouts, day 3	0.3	0.3	0.6	0.8	-0.7	0.6	0.5	-0.6	0.6	-0.1
Stereotopy head waving duration, day 3	0.3	0.4	0.9	0.9	-0.7	0.6	0.3	-0.4	0.4	-0.9
Locomotion velocity, session 7	0.4	0.5	1.1	-0.9	0.5	-0.5	-0.5	0.6	-0.5	1.1
Locomotion distance, session 7	0.6	0.8	1.1	-1.0	0.9	-0.9	-0.9	1.0	-0.9	0.4
Stereotopy head waving bouts, day 7	0.2	0.3	0.4	0.7	-0.5	0.5	0.5	-0.6	0.5	-0.4
Stereotopy head waving duration, day 7	0.4	0.4	0.8	0.9	-0.5	0.6	0.5	-0.7	0.6	-0.7
Locomotion velocity, session 8	0.0	0.0	0.0	-0.1	-0.1	0.0	0.2	0.0	0.1	0.2
Locomotion distance, session 8	0.4	0.6	0.8	-0.8	0.9	-0.8	-0.8	0.9	-0.8	-0.3
Degree of sensitization distance	1.2	1.2	1.5	-1.2	1.1	-1.2	-1.2	1.2	-1.2	-0.2
Degree of sensitization stereotypy	0.0	0.1	0.1	0.2	-0.1	0.2	0.2	-0.4	0.3	-0.1
Conditioned locomotion	0.2	0.2	1.4	0.2	0.2	-0.2	-0.2	0.3	-0.2	-1.2
Cocaine response after cond. corrected	0.7	0.9	1.3	-0.6	0.9	-0.9	-1.1	0.9	-0.9	-1.1
Cocaine response after cond. not corrected	0.6	0.8	1.5	-0.5	0.9	-0.9	-0.9	0.7	-0.8	-1.2
Cocaine response before conditioning	0.0	0.1	0.2	-0.0	-0.1	0.1	0.3	-0.4	0.3	0.1
Saline control response	0.3	0.4	0.6	-0.8	0.7	-0.7	-0.6	0.5	-0.5	-0.4
Bone: connectivity density	1.0	1.5	1.8	0.9	-1.3	1.3	1.3	-1.3	1.3	1.1
Bone: cortical apparent density	2.3	3.2	6.5	-2.5	1.7	-1.7	-1.7	1.7	-1.7	1.1
Bone: cortical area	0.1	0.2	0.4	-0.6	0.4	-0.4	-0.5	0.4	-0.5	0.2
Bone: cortical porosity	1.9	2.0	2.8	1.4	-1.5	1.5	1.5	-1.7	1.5	0.6
Bone: cortical porosity	2.1	2.3	3.1	1.5	-1.7	1.7	1.6	-1.8	1.6	0.1
Bone: cortical thickness	0.1	0.2	0.3	-0.5	0.4	-0.4	-0.5	0.4	-0.5	-0.0
Bone: cortical thickness	0.2	0.2	0.3	-0.3	0.4	-0.4	-0.6	0.5	-0.6	-0.1
Bone: cortical tissue density	2.1	2.8	6.0	-2.5	1.5	-1.5	-1.6	1.6	-1.6	1.1
Condit. Reinf. active minus inactive responses	1.3	1.5	9.3	0.7	0.4	-0.3	-0.3	0.3	-0.2	-3.0
Condit. Reinf. active-inactive response ratio	1.8	1.9	11.6	1.3	0.1	-0.0	-0.0	0.0	-0.0	-3.4
Condit. Reinf. active responses	0.7	0.8	5.3	0.5	0.4	-0.3	-0.2	0.1	0.0	-2.3
Condit. Reinf. inactive responses	0.4	0.5	0.8	-0.9	0.9	-0.9	-0.7	0.5	-0.4	-0.3
Incentive salience index mean	0.6	0.7	4.4	0.7	0.0	0.0	0.0	-0.1	0.2	-2.1
Condit. Reinf. lever presses	0.4	0.5	0.9	0.9	-0.5	0.5	0.7	-0.8	0.8	-0.9
Condit. Reinf. active minus inactive responses	0.6	0.7	2.3	1.3	-0.6	0.6	0.4	-0.5	0.4	-1.5
Condit. Reinf. active-inactive response ratio	1.2	1.4	3.3	1.8	-1.1	1.1	1.0	-1.0	0.9	-1.1
Condit. Reinf. active responses	0.2	0.3	0.9	0.1	0.4	-0.3	-0.6	0.4	-0.5	-1.0
Condit. Reinf. inactive responses	1.0	1.3	2.2	-1.5	1.1	-1.1	-1.3	1.1	-1.0	0.7
Condit. Reinf. lever presses	0.3	0.4	0.5	0.6	-0.7	0.7	0.6	-0.7	0.7	0.2
Condit. Reinf. lever reinforcers received	0.3	0.4	0.9	-0.1	0.5	-0.5	-0.7	0.5	-0.6	-0.9
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.2	0.4	-0.3	-0.4	0.3	-0.3	0.0
Conditioned reinforcement - inactives	0.0	0.1	0.1	-0.0	0.3	-0.2	-0.3	0.1	-0.2	-0.3
Conditioned locomotion	1.1	1.5	2.0	-1.4	1.2	-1.2	-1.3	1.2	-1.2	0.9
Patch foraging indifference point 0 sec	1.0	1.8	9.1	-1.7	0.4	-0.5	-0.3	-0.1	0.1	3.0
Patch foraging indifference point AUC	0.7	1.0	1.3	-1.2	1.1	-1.0	-0.9	1.2	-1.1	0.1
Delay disc. indifference point, 0s delay	0.4	0.5	1.4	-1.2	0.6	-0.6	-0.6	0.3	-0.5	0.5
Delay disc. indifference point, 16s delay	0.7	0.8	3.0	1.5	-0.4	0.5	0.1	-0.2	0.1	-1.7
Delay disc. indifference point, 2s delay	0.3	0.3	0.5	-0.5	0.7	-0.6	-0.7	0.5	-0.7	-0.1
Delay disc. indifference point, 24s delay	0.6	0.7	2.1	1.2	-0.3	0.3	0.6	-0.6	0.5	-1.4
Delay disc. indifference point, 4s delay	0.7	0.7	0.9	-0.5	0.9	-0.9	-1.0	0.8	-0.8	-0.9
Delay disc. indifference point, 8s delay	0.2	0.2	0.9	0.1	0.2	-0.1	-0.3	0.3	-0.4	-1.0
Indifference point function ln k	0.2	0.3	0.7	-0.9	0.5	-0.7	-0.7	0.1	-0.3	0.3
Indifference point function log k	0.2	0.3	0.7	-0.9	0.5	-0.7	-0.7	0.1	-0.3	0.3
Patch foraging total patch changes 0 sec	1.1	2.2	9.2	-2.0	0.7	-0.8	-0.7	0.3	-0.3	3.0
Patch foraging total patch changes 12 sec	0.5	0.6	3.4	-0.8	0.1	0.1	0.2	-0.1	0.2	1.8
Patch foraging total patch changes 18 sec	1.3	2.1	4.9	-2.2	1.3	-1.4	-1.1	1.0	-1.0	1.6
Patch foraging total patch changes 24 sec	0.5	0.9	3.4	-1.4	0.6	-0.5	-0.1	0.1	-0.2	1.9
Patch foraging total patch changes 6 sec	0.7	1.1	6.5	-0.9	0.0	0.1	0.1	-0.2	0.2	2.5
Patch foraging time to switch 0 sec	0.5	1.0	1.7	1.3	-1.2	1.3	1.0	-0.8	0.8	0.1
Patch foraging water rate 0 sec	0.4	0.8	1.4	-1.1	1.2	-1.2	-1.0	0.6	-0.6	-0.2
Patch foraging water rate 12 sec	0.3	0.6	2.7	-0.9	0.3	-0.4	-0.4	-0.0	-0.1	1.7
Patch foraging water rate 18 sec	0.3	0.5	0.6	0.5	-0.7	0.7	0.5	-0.7	0.8	0.7
Patch foraging water rate 24 sec	0.0	0.1	0.1	0.4	-0.2	0.1	-0.1	0.1	-0.0	-0.4
Patch foraging water rate 6 sec	0.1	0.2	1.0	-0.6	0.1	-0.2	-0.3	0.1	-0.1	1.0
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.7	0.8	-0.6	0.6	0.3	-0.1	0.1	-0.5
Distance traveled before self-admin	1.2	1.6	2.2	1.4	-1.4	1.5	1.3	-1.1	1.2	0.8
Distance traveled after self-admin	4.0	4.9	6.2	2.4	-2.5	2.4	2.4	-2.2	2.2	1.0
Extensor digitorum longus weight	5.9	23.2	32.9	-5.7	5.2	-5.2	-5.2	4.9	-5.0	-0.4
Bone: elastic displacement	0.9	1.0	1.4	1.2	-1.2	1.2	0.8	-0.8	0.8	1.0
Bone: elastic work	0.5	0.6	1.0	1.0	-0.9	0.9	0.7	-0.7	0.7	0.0
Bone: endosteal estimation	0.0	0.0	0.1	0.2	0.0	-0.0	0.1	-0.1	0.1	-0.0
Bone: endosteal perimeter	0.0	0.0	0.2	-0.0	-0.0	0.0	-0.2	0.2	-0.2	-0.4
Epididymis fat weight	0.3	0.9	1.2	-1.0	1.0	-1.0	-1.1	1.0	-1.1	-0.1
Delta time in closed arm before/after self-admin	0.6	0.6	2.4	0.1	-0.6	0.6	0.6	-0.5	0.5	1.5
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.1	-0.4	0.5	0.1	-0.2	0.3	-0.3
Diff in mean of infusions in LGA sessions	0.2	0.3	0.4	0.6	-0.4	0.3	0.6	-0.4	0.5	0.6
Delay discount exponential model param	0.7	0.8	3.0	-0.2	-0.7	0.6	0.8	-0.6	0.7	1.7
Extinction: sum of active levers before priming	0.5	0.5	1.1	1.0	-0.9	0.7	0.7	-0.6	0.6	-0.3
Active lever presses in extinction session 6	1.0	1.0	1.3	-0.4	1.0	-1.1	-1.0	1.0	-1.1	-1.1
Bone: final force	0.0	0.1	0.2	-0.2	0.2	-0.2	-0.0	-0.3	0.2	-0.5
Bone: final moment	0.0	0.1	0.2	-0.3	0.2	-0.2	-0.0	-0.2	0.2	-0.4
Food consumed during 24 hour testing period	0.8	1.0	1.4	-0.9	1.0	-1.0	-1.2	1.0	-1.0	-0.9
Glucose	0.1	0.1	0.5	0.7	-0.4	0.4	0.1	-0.2	0.1	-0.4
Heart weight	0.1	0.1	0.2	-0.4	0.3	-0.3	-0.1	0.4	-0.3	0.5
Delay discount hyperbolic model param	0.7	0.8	2.9	-0.1	-0.7	0.7	0.8	-0.6	0.7	1.7
Intermittent access intake day 1-15 change	0.4	0.9	1.4	1.2	-1.0	1.0	0.9	-0.8	0.8	-0.7
Intermittent access intake escalation	0.5	1.1	1.6	1.3	-1.1	1.2	1.1	-1.0	1.0	-0.4
Intermittent access intake escalation 2	1.7	2.0	3.1	1.8	-1.6	1.7	1.4	-1.3	1.3	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.3	0.5	-0.2	0.1	0.1	-0.2	0.2	-0.5
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.7	-0.1	0.1	0.1	-0.1	0.1	-0.1	0.8
Intermitt. access escalation Index	0.8	1.1	4.5	1.4	-0.4	0.6	0.5	-0.5	0.5	-2.1
Intermittent access day 1 total infusions	0.2	0.3	0.7	0.1	0.7	-0.5	-0.4	0.4	-0.4	-0.8
Intermittent access day 15 total infusions	0.5	0.8	1.9	1.4	-0.6	0.7	0.8	-0.8	0.8	-0.9
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.5	0.7	-0.0	0.2	0.1	-0.1	0.1	-0.4
Intermittent access total infusions	0.1	0.1	0.4	0.6	-0.0	0.2	0.3	-0.3	0.3	-0.5
Intermittent access day 1 locomotion	0.4	0.6	0.9	-0.6	0.9	-0.9	-0.8	0.8	-0.8	-0.3
Intermittent access day 15 total locomotion	0.1	0.2	0.4	-0.5	0.6	-0.6	-0.3	0.4	-0.4	-0.0
Intermittent access total locomotion	0.4	0.5	0.8	-0.6	0.9	-0.8	-0.6	0.7	-0.7	0.1
Intermittent access standard deviation	0.2	0.4	0.9	0.9	-0.7	0.5	0.5	-0.6	0.6	-0.6
Left kidney weight	0.1	0.7	1.3	0.5	-0.6	0.7	1.0	-1.1	1.1	0.5
Right kidney weight	0.0	0.1	0.1	-0.4	0.3	-0.3	0.0	-0.2	-0.0	0.3
Cocaine induced anxiety	0.0	0.0	0.1	0.1	0.2	-0.2	0.1	-0.0	0.1	-0.3
Post-drug Anxiety	0.7	0.7	1.1	-0.5	1.1	-1.0	-0.8	0.9	-0.9	-0.7
Baseline Anxiety	1.2	1.4	2.0	-0.8	1.2	-1.1	-1.2	1.2	-1.2	-1.4
Tail length	0.7	2.8	4.7	2.2	-1.3	1.3	1.7	-1.7	1.7	-1.7
Length with tail	0.6	2.8	4.8	2.2	-1.2	1.2	1.8	-1.7	1.7	-1.7
Length without tail	0.0	0.1	0.2	-0.2	0.4	-0.4	0.2	-0.1	0.1	0.0
Times rat made contact with spout	0.4	0.5	0.6	0.8	-0.6	0.6	0.7	-0.7	0.8	-0.7
Lifetime Intake	0.1	0.1	0.1	0.0	0.4	-0.3	-0.3	0.2	-0.2	-0.3
Liver weight, left	0.1	0.1	0.5	-0.3	0.1	-0.1	-0.1	0.0	-0.0	0.7
Liver weight, right	0.1	0.2	0.4	0.6	-0.3	0.3	0.4	-0.5	0.5	-0.2
Locomotor activity	0.2	0.3	0.6	0.7	-0.8	0.6	0.6	-0.4	0.3	0.1
Locomotor testing distance	1.0	1.9	2.9	1.6	-1.7	1.6	1.4	-1.2	1.1	0.4
Locomotor testing rearing	1.7	3.4	5.2	2.3	-2.1	2.0	1.9	-1.8	1.9	-0.3
Locomotion in novel chamber	6.5	8.3	10.2	-3.2	3.1	-3.0	-3.1	3.1	-3.1	-0.5
Locomotion in novel chamber post-restriction	2.7	4.4	5.6	-2.2	2.1	-2.2	-2.3	2.4	-2.4	-0.3
Fecal boli incidents, locomotor time 1	1.2	1.8	2.2	-1.5	1.4	-1.5	-1.4	1.2	-1.5	-0.6
Change in fecal boli incidents, locomotor task	0.3	0.2	1.0	-0.3	-0.2	0.2	0.5	-0.4	0.5	1.0
Time >=10cm from walls, locomotor time 1	1.7	1.8	2.8	-1.4	1.3	-1.3	-1.2	1.6	-1.7	0.4
Bouts of movement, locomotor time 1	8.4	9.5	11.6	-3.0	3.3	-3.3	-3.1	3.4	-3.3	-2.0
Total resting periods, locomotor time 1	8.8	9.8	11.8	-2.9	3.4	-3.4	-3.2	3.4	-3.4	-1.9
Rest time, locomotor task time 1	0.9	1.1	2.0	-0.4	0.9	-0.9	-0.9	1.3	-1.3	-1.4
Distance moved, locomotor task time 1	0.3	0.5	1.8	-0.0	-0.5	0.5	0.7	-0.6	0.7	1.3
Vertical activity count, locomotor time 1	0.6	1.5	1.9	0.6	-1.4	1.3	1.1	-1.3	1.3	1.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.4	-0.1	-0.1	0.2	-0.1	0.2	-0.2	0.7
Bouts of movement, locomotor time 2	2.4	3.8	5.5	-1.8	2.0	-2.0	-2.1	2.4	-2.4	-0.6
Total resting periods, locomotor time 2	1.9	3.2	4.8	-1.8	1.8	-1.8	-1.8	2.2	-2.2	-0.1
Rest time, locomotor task time 2	0.1	0.1	0.2	0.5	-0.3	0.3	0.4	-0.1	0.1	0.0
Distance moved, locomotor task time 2	0.3	0.4	1.2	-1.1	0.7	-0.6	-0.5	0.3	-0.2	0.5
Vertical activity count, locomotor time 2	0.4	0.5	0.7	-0.8	0.6	-0.6	-0.9	0.7	-0.7	-0.6
Light reinforcement 1	2.8	7.0	13.1	-3.6	2.8	-2.7	-2.7	2.4	-2.4	1.4
Light reinforcement 2	1.8	2.8	5.5	-2.4	1.5	-1.5	-1.4	1.4	-1.3	2.0
Bone: marrow area	0.0	0.0	0.0	0.2	0.1	-0.1	0.0	-0.1	0.1	-0.2
Bone: maximum diameter	0.0	0.0	0.1	0.1	-0.2	0.2	0.2	-0.1	0.1	0.4
Bone: maximum force	0.1	0.2	0.4	-0.6	0.4	-0.4	-0.4	0.3	-0.3	-0.3
Bone: maximum moment	0.1	0.2	0.5	-0.7	0.5	-0.5	-0.5	0.3	-0.3	-0.2
Mean time between licks in bursts	1.0	2.4	5.0	-2.2	1.3	-1.3	-1.3	1.2	-1.1	2.0
Mean num. licks in bursts	0.2	0.3	0.5	-0.7	0.5	-0.5	-0.7	0.5	-0.6	-0.2
Cd content in liver	2.9	3.2	6.8	2.6	-1.6	1.6	1.6	-1.6	1.6	-1.8
Co content in liver	1.7	2.0	6.0	1.8	-0.9	0.9	1.0	-0.9	0.9	-2.5
Cu content in liver	0.8	0.9	3.1	1.2	-0.5	0.6	0.7	-0.7	0.7	-1.8
Fe content in liver	2.7	3.3	4.3	1.8	-1.8	1.7	2.0	-2.1	2.0	1.1
K content in liver	1.6	1.5	2.9	-1.7	1.0	-1.1	-1.0	0.9	-1.0	1.7
Mg content in liver	0.1	0.1	0.6	-0.5	0.1	-0.2	-0.1	0.2	-0.2	0.7
Mn content in liver	0.3	0.4	1.2	-1.1	0.4	-0.5	-0.6	0.5	-0.5	0.4
Na content in liver	2.6	2.8	8.2	0.6	-1.5	1.5	1.5	-1.6	1.5	2.9
Rb content in liver	5.5	6.4	7.5	-2.4	2.7	-2.6	-2.6	2.5	-2.7	-2.0
Se content in liver	0.7	0.9	1.2	-0.9	1.1	-1.1	-1.0	1.0	-1.0	0.2
Sr content in liver	0.1	0.0	0.2	0.2	-0.1	0.1	0.0	-0.2	0.0	0.4
Zn content in liver	0.4	0.4	0.8	0.9	-0.5	0.5	0.6	-0.6	0.5	-0.9
Bone: minimum diameter	0.4	0.7	1.1	-1.0	1.0	-1.0	-0.9	0.8	-0.8	0.4
Time in familiar zone, hab. session 1	0.3	0.3	1.7	0.6	-0.0	-0.0	0.1	0.0	0.0	-1.3
Time in novel zone, hab. session 1	1.0	1.0	1.4	0.9	-1.0	1.1	1.1	-1.2	1.1	0.6
Total zone transitions, hab. session 1	0.1	0.2	0.9	-0.1	-0.3	0.3	0.2	-0.3	0.3	0.9
Total locomotion distance, hab. session 1	0.7	1.0	1.6	-1.3	1.0	-1.0	-1.1	1.0	-1.0	0.3
Locomotion velocity, hab. session 1	0.7	1.0	1.7	-1.3	0.9	-0.9	-1.0	1.0	-1.0	0.6
Time in familiar zone, hab. session 2	0.5	0.5	0.8	0.8	-0.7	0.8	0.9	-0.7	0.8	0.2
Time in novel zone, hab. session 2	0.1	0.1	0.5	0.1	0.1	-0.1	-0.2	0.1	-0.1	-0.7
Total zone transitions, hab. session 2	0.5	0.6	0.7	-0.6	0.8	-0.8	-0.8	0.8	-0.8	-0.7
Total locomotion distance, hab. session 2	1.4	1.8	2.1	-1.1	1.4	-1.4	-1.4	1.5	-1.4	-1.3
Locomotion velocity, hab. session 2	1.2	1.6	1.9	-1.1	1.3	-1.3	-1.3	1.4	-1.3	-1.0
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.4	0.2	-0.2	-0.3
Novelty place preference	0.1	0.1	0.2	-0.1	0.2	-0.2	-0.3	0.1	-0.1	-0.4
Time in novel zone, NPP test	0.0	0.0	0.2	0.1	-0.0	-0.0	-0.1	-0.1	0.1	-0.4
Total zone transitions, NPP test	0.4	0.6	1.5	-0.3	0.7	-0.7	-0.7	0.8	-0.7	-1.2
Total locomotion distance, NPP test	0.6	0.8	1.3	-0.8	0.9	-0.9	-1.0	1.1	-1.0	-0.5
Locomotion velocity, NPP test	0.9	1.2	1.9	-1.2	1.1	-1.1	-1.2	1.4	-1.2	-0.1
Intraocular pressure	2.6	3.7	4.9	-1.6	2.1	-2.1	-2.2	1.9	-2.1	-1.2
Delta distance traveled before/after self-admin	0.3	0.3	0.5	0.5	-0.7	0.5	0.6	-0.7	0.6	0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.4	0.0	-0.3	0.2	0.3	-0.4	0.3	0.6
Parametrial fat weight	0.5	1.1	2.3	-1.0	0.8	-0.9	-1.1	1.5	-1.4	0.0
Pavlov. Cond. lever latency	0.7	0.8	1.1	-1.1	0.9	-0.9	-1.0	0.9	-0.9	0.5
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	0.5	-0.3	0.4	0.5	-0.4	0.5	-0.4
Pavlov. Cond. change in total contacts	0.3	0.3	1.3	-0.2	0.6	-0.6	-0.3	0.3	-0.3	-1.2
Pavlov. Cond. index score	0.4	0.4	0.7	0.8	-0.6	0.6	0.7	-0.6	0.7	-0.7
Pavlov. Cond. latency score	0.5	0.6	0.9	1.0	-0.7	0.7	0.8	-0.7	0.8	-0.7
Pavlov. Cond. lever contacts	0.3	0.3	0.4	0.7	-0.6	0.6	0.6	-0.5	0.5	-0.5
Pavlov. Cond. magazine entry number	0.9	1.1	1.9	-1.4	0.9	-1.0	-1.0	1.0	-1.1	0.7
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.5	-0.3	0.6	-0.7	-0.9	0.7	-0.7	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.8	0.5	-0.2	0.2	0.3	-0.2	0.3	-0.9
Pavlov. Cond. response bias	0.2	0.3	0.5	0.7	-0.3	0.4	0.5	-0.5	0.5	-0.7
Pavlov. Cond. lever latency	1.0	1.4	2.0	-0.9	1.1	-1.2	-1.2	1.4	-1.4	-0.9
Pavlov. Cond. magazine entry latency	1.0	1.2	1.8	1.1	-1.1	1.1	1.2	-1.3	1.3	0.4
Pavlov. Cond. change in total contacts	0.6	1.0	1.3	0.8	-0.9	1.0	0.9	-1.1	1.1	1.0
Pavlov. Cond. index score	0.8	1.0	1.5	0.7	-0.9	0.9	1.0	-1.2	1.2	1.0
Pavlov. Cond. latency score	0.5	0.7	1.0	0.5	-0.7	0.7	0.8	-1.0	1.0	1.0
Pavlov. Cond. lever contacts	1.6	2.2	3.1	1.2	-1.5	1.5	1.6	-1.8	1.7	0.9
Pavlov. Cond. magazine entry number	1.4	1.7	2.5	-1.1	1.2	-1.2	-1.3	1.6	-1.5	-0.9
Pavlov. Cond. intertrial magazine entries	3.0	4.5	5.6	-2.0	2.2	-2.2	-2.3	2.4	-2.4	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.2	0.5	-0.7	0.8	0.9	-1.1	1.1	1.0
Pavlov. Cond. response bias	2.6	3.5	4.9	1.6	-1.9	1.9	2.0	-2.2	2.2	1.2
Time in closed arm before self-admin	0.5	0.7	1.9	1.3	-0.2	0.3	0.4	-0.5	0.6	-1.4
Time in closed arm after self-admin	1.3	1.4	2.7	1.6	-1.0	1.1	1.2	-1.3	1.3	0.1
Time in open arm before self-admin	1.4	1.5	3.4	-1.9	1.2	-1.1	-1.0	1.1	-1.2	0.7
Time in open arm after self-admin	0.1	0.1	0.3	-0.5	-0.3	0.3	0.1	0.1	-0.1	0.4
Bone: periosteal estimation	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	0.1	-0.1
Bone: periosteal perimeter	0.0	0.1	0.2	0.3	-0.1	0.1	-0.0	0.0	-0.0	-0.5
Bone: post-yield work	0.0	0.0	0.1	-0.3	-0.1	0.1	0.2	-0.2	0.2	-0.3
Progressive ratio test 1 active lever presses	0.8	1.0	1.6	-0.7	1.3	-1.2	-0.9	1.0	-1.0	-0.8
Progressive ratio test 1 breakpoint	0.7	0.9	1.4	-0.6	1.2	-1.1	-0.9	0.9	-1.0	-0.7
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.3	-0.4	0.5	-0.4	-0.4	0.4	-0.4	0.5
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	0.0	0.4	-0.4	-0.5	0.4	-0.4	-0.7
Progressive ratio test 2 breakpoint	0.2	0.2	0.6	-0.0	0.5	-0.4	-0.5	0.4	-0.4	-0.8
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.4	-0.1	0.2	0.2	-0.2	0.2	-0.0
Incentive Sensitization - Responses	0.3	0.4	1.3	1.1	-0.6	0.7	0.4	-0.5	0.5	-0.5
Incentive Sensitization - Breakpoint	0.3	0.4	1.1	1.1	-0.5	0.6	0.4	-0.4	0.4	-0.6
Sum of active levers in priming session hrs 5-6	1.1	1.1	1.3	1.1	-1.1	1.0	1.1	-1.1	1.1	0.6
Progressive ratio	2.5	3.9	4.7	-1.6	2.0	-2.2	-2.1	1.9	-2.0	-2.1
Food seeking constrained by brief footshock	0.0	0.1	0.1	-0.4	0.1	-0.2	-0.3	0.1	-0.3	0.1
Seeking ratio, punishment vs. effort	1.0	1.5	2.9	0.8	-1.1	1.3	1.2	-1.1	1.1	1.7
Retroperitoneal fat weight	0.5	2.1	3.2	-1.4	1.6	-1.5	-1.4	1.8	-1.7	0.0
Reaction time number correct	0.6	1.1	2.1	-1.4	1.3	-1.2	-1.2	0.7	-0.7	0.1
Reaction time mean minus median	0.7	1.7	3.0	1.7	-1.7	1.6	1.2	-1.1	1.0	0.4
Reaction time mean minus median AUC	0.7	1.9	3.4	1.9	-1.7	1.6	1.2	-1.3	1.2	0.0
Reaction time num false alarms	1.2	1.7	2.1	-1.3	1.4	-1.4	-1.5	1.4	-1.4	-0.7
Reaction time num false alarms AUC	1.5	2.4	3.0	-1.7	1.7	-1.6	-1.6	1.7	-1.6	-0.3
Reaction time trials correct on left	0.6	1.1	2.1	-1.4	1.3	-1.2	-1.2	0.7	-0.7	0.1
Reaction time trials on left	0.5	1.0	1.8	-1.3	1.3	-1.1	-1.2	0.6	-0.7	0.1
Reaction time mean	2.1	3.4	6.3	2.5	-2.0	1.9	1.9	-1.8	1.7	-0.9
Reaction time mean AUC	1.6	2.5	4.9	2.2	-1.6	1.6	1.5	-1.4	1.3	-1.1
Median of all reaction times	2.2	3.1	5.7	2.4	-1.7	1.6	1.8	-1.6	1.6	-1.4
Reaction time omissions	1.1	1.6	2.8	1.7	-1.4	1.3	1.2	-1.4	1.2	-0.2
Reaction time false alarm rate	0.5	0.7	1.3	-0.7	0.8	-0.8	-0.8	1.1	-1.1	-0.3
Reaction time premature initiation rate	0.2	0.2	0.4	0.4	-0.6	0.5	0.6	-0.5	0.4	0.3
Reaction time premature initiations	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.1	-0.1	0.1	0.3
Std. dev. reaction times	1.9	3.5	5.3	2.3	-2.3	2.1	1.9	-1.8	1.7	0.4
Reaction time trials completed	0.5	1.0	1.8	-1.3	1.3	-1.1	-1.2	0.6	-0.7	0.1
Reaction time trials AUC	0.5	0.9	1.6	-1.3	1.3	-1.1	-1.1	0.6	-0.7	-0.0
Run reversals in cocaine runway, females	0.8	0.8	1.4	-0.0	0.6	-0.7	-0.9	1.2	-1.0	-1.2
Run reversals in cocaine runway, males	0.4	0.4	0.7	-0.6	0.7	-0.5	-0.8	0.8	-0.8	-0.3
Latency to leave start box in cocaine runway	1.9	2.2	3.0	-1.7	1.4	-1.4	-1.6	1.7	-1.7	0.2
Latency to leave start box in cocaine runway, F	0.5	0.5	1.0	-1.0	0.3	-0.4	-0.7	0.8	-0.8	1.0
Latency to leave start box in cocaine runway, M	3.7	3.4	4.7	-1.8	2.2	-2.0	-1.9	1.9	-1.9	-1.1
Std. dev. time between licks in bursts	0.9	1.2	2.6	-1.6	1.1	-1.0	-0.9	0.7	-0.7	1.2
Total sessions with >9 infusions	1.6	2.0	3.1	-1.8	1.4	-1.4	-1.5	1.5	-1.5	0.7
Short access day 1 total inactive lever presses	0.6	0.8	1.8	-1.3	0.6	-0.5	-0.8	0.7	-0.7	1.2
Short access day 10 total inactive lever presses	0.1	0.2	0.3	0.4	-0.5	0.6	0.3	-0.5	0.5	-0.4
Short access day 1 total infusions	1.4	1.9	3.4	-1.8	1.3	-1.3	-1.4	1.3	-1.4	0.8
Short access day 10 total infusions	0.5	0.6	1.0	-0.1	1.0	-0.8	-0.8	0.7	-0.8	-1.0
Short access total infusions	1.1	1.4	1.8	-1.1	1.3	-1.2	-1.4	1.3	-1.3	-0.5
Short access day 1 locomotion	1.1	1.4	3.1	-1.8	1.5	-1.4	-1.0	0.7	-0.7	0.7
Short access day 10 total locomotion	0.0	0.0	0.1	-0.1	0.0	-0.1	0.2	-0.0	0.0	0.3
Short access total locomotion	1.1	1.3	2.0	-1.4	1.4	-1.4	-1.1	1.1	-1.1	-0.1
One hour access (0.3 mA shock)	0.3	0.3	1.9	0.4	0.4	-0.4	-0.2	0.2	-0.2	-1.4
Compulsive drug intake	0.2	0.2	1.0	-0.0	-0.2	0.4	0.2	-0.4	0.3	1.0
One hour access (shock baseline)	0.2	0.3	1.9	0.6	0.0	-0.1	0.2	-0.1	0.1	-1.4
Social response proportion	0.6	0.7	1.5	0.8	-0.0	0.2	0.7	-1.1	1.0	-1.2
Social responses	1.1	1.4	2.9	1.7	-0.8	1.0	1.1	-1.1	1.2	-1.2
Social time	4.2	5.7	7.8	2.8	-2.4	2.4	2.6	-2.7	2.7	0.1
Soleus weight	0.8	2.5	4.3	-2.1	1.6	-1.5	-1.4	1.4	-1.3	1.7
Bone: stiffness	0.1	0.2	0.5	-0.7	0.6	-0.6	-0.2	0.1	-0.2	-0.7
Tibialis anterior weight	2.2	7.5	12.7	-3.6	2.9	-2.9	-2.8	2.7	-2.7	0.5
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.1	-0.1	0.1	0.1	0.0	0.0	-0.2
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.5	0.7	-0.4	0.4	0.4	-0.3	0.5	-0.6
Time to tail flick, test, before self-admin	1.0	1.0	1.5	-1.0	1.0	-1.1	-1.1	1.2	-1.0	-0.4
Time to tail flick, test, after self-admin	2.9	3.0	3.4	-1.9	1.8	-1.9	-1.8	1.8	-1.8	-1.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.1	-0.0	0.0	0.2	-0.2	0.3	0.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.5	0.3	-0.3	-0.3	0.1	-0.3	-0.2
Tibia length	0.2	0.5	0.7	0.4	-0.7	0.8	0.8	-0.8	0.8	0.4
Ambulatory time before self-admin	0.9	1.3	2.2	1.5	-1.3	1.4	1.1	-1.0	1.1	0.1
Ambulatory time after self-admin	2.0	2.4	3.3	1.5	-1.8	1.7	1.6	-1.5	1.4	1.2
Bone: tissue strength	0.2	0.2	0.7	-0.1	0.4	-0.4	-0.2	0.2	-0.1	-0.8
Total heroin consumption	0.1	0.1	0.5	0.0	0.3	-0.4	-0.3	0.2	-0.3	-0.7
Bone: trabecular number	3.8	6.3	8.0	2.2	-2.8	2.8	2.8	-2.7	2.8	0.8
Bone: trabecular spacing	2.9	3.8	5.1	-1.7	2.1	-2.1	-2.2	2.3	-2.1	-1.0
Bone: trabecular thickness	6.1	7.7	9.3	2.9	-3.0	3.0	3.0	-3.1	3.0	0.1
Bone: trabecular tissue density	0.1	0.1	0.2	0.0	-0.5	0.5	0.3	-0.2	0.2	-0.3
Water consumed over 24 hours	0.3	0.4	2.2	0.3	0.3	-0.3	-0.1	-0.1	0.0	-1.5
Number of responses in last shaping day	0.0	0.0	0.0	0.1	-0.1	0.2	0.1	0.1	-0.1	0.1