Hub : Genes

Pnpla8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Pnpla8 0.24 0.13 1.0e-06 0.05 0.05 0.06 0.05 7.9e-06 2.8e-06 4.0e-07 6.6e-06
2 Liver gene expression Pnpla8 0.05 0.03 2.4e-06 0.05 0.05 0.04 0.04 4.9e-06 1.1e-06 1.4e-05 8.4e-06
3 NAcc gene expression Pnpla8 0.11 0.06 5.3e-07 0.06 0.05 0.06 0.06 8.2e-08 1.8e-06 4.1e-07 9.0e-08
4 OFC gene expression Pnpla8 0.2 0.11 3.5e-04 0.13 0.11 0.13 0.15 5.5e-04 1.3e-03 6.6e-04 2.5e-04
5 Brain gene expression Pnpla8 0.1 0.05 4.7e-08 0.04 0.07 0.06 0.06 5.8e-05 8.8e-07 7.7e-06 1.3e-06
6 BLA gene expression Pnpla8 0.06 0.04 4.7e-03 0.01 0.02 0.03 0.01 8.7e-02 3.5e-02 1.3e-02 6.5e-02
7 Adipose gene expression Pnpla8 0.19 0.08 1.9e-15 0.1 0.1 0.1 0.1 1.1e-11 3.2e-11 1.5e-11 2.5e-11
8 Adipose mRNA stability Pnpla8 0.11 0.05 4.0e-10 0.07 0.06 0.07 0.06 3.1e-08 1.4e-07 5.4e-08 1.3e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.01.73.8-2.00.3-1.61.51.3-0.6-1.1-1.1
Area under the delay curve0.20.20.5-0.10.10.3-0.10.50.1-0.7-0.7
BMI with tail1.23.79.60.8-2.91.7-2.3-1.43.10.70.7
BMI without tail1.32.78.8-0.0-3.01.7-1.8-0.52.6-0.2-0.2
Body weight1.14.711.0-3.3-0.1-1.51.02.80.0-2.8-2.8
Weight adjusted by age1.11.22.2-1.30.4-0.90.71.5-0.5-1.5-1.5
Bone surface2.34.16.6-2.61.1-2.22.32.3-1.3-2.0-2.0
Bone volume1.42.35.4-2.30.5-1.81.81.6-0.8-1.4-1.4
Breakpoint value in progressive ratio session2.72.94.6-2.11.5-2.02.01.8-1.4-1.3-1.3
Number of licking bursts0.20.20.60.80.10.7-0.5-0.40.00.50.5
Context. condit. distance diff. score0.70.92.3-1.50.6-1.11.00.9-0.7-0.6-0.6
Locomotion velocity, session 11.11.21.80.8-0.91.2-0.8-1.31.01.21.2
Locomotion distance, session 10.50.71.51.2-0.71.0-0.7-1.00.50.60.6
Locomotion velocity, session 21.21.33.21.8-0.41.3-1.0-1.40.61.01.0
Locomotion distance, session 20.50.81.51.2-0.40.8-0.5-1.20.41.01.0
Locomotion velocity, session 30.30.30.60.60.5-0.10.10.6-0.6-0.8-0.8
Locomotion distance, session 31.21.32.0-0.70.9-1.11.21.4-1.1-1.3-1.3
Stereotopy head waving bouts, day 30.81.01.91.2-1.11.2-1.4-0.61.10.20.2
Stereotopy head waving duration, day 30.70.81.61.2-0.40.8-1.1-1.00.50.90.9
Locomotion velocity, session 70.91.02.0-0.00.6-0.80.51.2-1.0-1.4-1.4
Locomotion distance, session 71.41.84.9-0.30.4-0.60.31.9-0.7-2.2-2.2
Stereotopy head waving bouts, day 70.00.00.10.0-0.2-0.0-0.40.0-0.1-0.3-0.3
Stereotopy head waving duration, day 70.40.51.01.0-0.60.5-0.7-1.00.40.60.6
Locomotion velocity, session 82.22.77.40.7-0.10.40.2-2.40.42.72.7
Locomotion distance, session 80.30.51.2-0.60.5-0.81.1-0.4-0.60.70.7
Degree of sensitization distance0.10.10.2-0.10.3-0.3-0.20.5-0.4-0.5-0.5
Degree of sensitization stereotypy0.10.10.3-0.40.4-0.50.20.0-0.5-0.1-0.1
Conditioned locomotion5.96.911.53.1-2.83.4-2.8-2.33.01.41.4
Cocaine response after cond. corrected0.20.20.60.10.6-0.70.20.2-0.8-0.2-0.2
Cocaine response after cond. not corrected0.40.41.3-0.40.6-1.10.50.5-0.8-0.4-0.4
Cocaine response before conditioning1.51.84.0-1.00.4-1.00.61.8-0.7-2.0-2.0
Saline control response1.31.73.4-1.70.7-0.91.21.8-0.6-1.5-1.5
Bone: connectivity density2.23.47.3-2.71.1-2.52.41.5-1.4-1.0-1.0
Bone: cortical apparent density1.11.43.21.3-1.01.2-1.8-1.01.20.80.8
Bone: cortical area0.81.21.7-1.31.2-1.21.30.9-1.3-0.6-0.6
Bone: cortical porosity0.00.00.10.2-0.00.30.1-0.30.10.20.2
Bone: cortical porosity0.20.20.5-0.40.6-0.30.70.1-0.50.10.1
Bone: cortical thickness0.10.10.3-0.5-0.1-0.20.2-0.30.00.40.4
Bone: cortical thickness1.01.22.00.8-0.80.9-0.9-1.40.91.41.4
Bone: cortical tissue density1.01.43.11.3-1.01.2-1.8-0.91.20.90.9
Condit. Reinf. active minus inactive responses2.93.35.9-1.72.4-1.82.11.8-2.3-0.9-0.9
Condit. Reinf. active-inactive response ratio2.42.63.8-1.51.8-1.41.71.9-1.8-1.4-1.4
Condit. Reinf. active responses4.35.210.4-2.33.2-2.62.81.5-3.0-0.3-0.3
Condit. Reinf. inactive responses1.11.42.2-0.91.5-1.21.1-0.5-1.21.31.3
Incentive salience index mean4.25.010.2-2.23.2-2.52.71.5-3.0-0.4-0.4
Condit. Reinf. lever presses3.14.18.2-1.92.9-2.42.50.9-2.8-0.0-0.0
Condit. Reinf. active minus inactive responses0.91.24.2-0.42.0-1.00.70.5-1.70.20.2
Condit. Reinf. active-inactive response ratio0.20.30.80.70.90.3-0.60.1-0.50.10.1
Condit. Reinf. active responses1.52.15.8-0.82.4-1.61.50.7-2.20.10.1
Condit. Reinf. inactive responses1.21.53.2-1.01.4-1.51.80.9-1.5-0.4-0.4
Condit. Reinf. lever presses1.41.92.9-1.71.5-1.71.61.2-1.3-0.8-0.8
Condit. Reinf. lever reinforcers received2.23.27.8-1.42.8-2.12.00.9-2.50.10.1
Conditioned reinforcement - actives1.61.63.4-1.21.8-1.51.40.8-1.8-0.1-0.1
Conditioned reinforcement - inactives2.02.34.2-1.92.0-1.41.51.4-1.7-0.7-0.7
Conditioned locomotion0.70.81.4-1.11.2-1.11.00.4-1.20.10.1
Patch foraging indifference point 0 sec3.25.19.5-2.52.7-2.33.12.2-2.2-1.3-1.3
Patch foraging indifference point AUC2.02.43.7-1.51.9-1.61.9-0.3-1.41.51.5
Delay disc. indifference point, 0s delay0.20.21.2-1.10.5-0.40.40.2-0.10.10.1
Delay disc. indifference point, 16s delay0.30.30.5-0.70.5-0.40.60.7-0.6-0.6-0.6
Delay disc. indifference point, 2s delay0.50.51.4-0.5-0.10.20.01.00.3-1.2-1.2
Delay disc. indifference point, 24s delay0.10.10.30.2-0.20.4-0.1-0.30.50.20.2
Delay disc. indifference point, 4s delay1.01.11.81.3-1.01.3-1.3-1.01.00.60.6
Delay disc. indifference point, 8s delay0.60.61.9-0.4-0.1-0.10.11.1-0.0-1.4-1.4
Indifference point function ln k1.01.54.10.1-1.00.5-0.61.20.6-2.0-2.0
Indifference point function log k1.01.54.10.1-1.00.5-0.61.20.6-2.0-2.0
Patch foraging total patch changes 0 sec3.04.88.9-2.52.6-2.23.02.1-2.1-1.3-1.3
Patch foraging total patch changes 12 sec2.02.65.8-1.72.2-1.72.40.6-1.70.60.6
Patch foraging total patch changes 18 sec1.31.74.4-1.61.6-1.02.11.1-1.1-0.5-0.5
Patch foraging total patch changes 24 sec1.72.15.1-1.42.3-1.51.90.5-1.70.40.4
Patch foraging total patch changes 6 sec3.55.111.1-2.63.0-2.63.30.9-2.40.40.4
Patch foraging time to switch 0 sec5.58.514.83.0-3.83.5-3.4-2.33.81.01.0
Patch foraging water rate 0 sec3.25.27.4-2.62.1-2.12.02.7-2.2-2.1-2.1
Patch foraging water rate 12 sec3.14.87.1-2.61.9-2.32.72.2-2.2-1.7-1.7
Patch foraging water rate 18 sec0.70.91.8-0.90.4-0.80.61.3-0.5-1.3-1.3
Patch foraging water rate 24 sec0.71.02.3-0.9-0.2-0.51.01.2-0.3-1.5-1.5
Patch foraging water rate 6 sec0.91.33.1-1.80.9-1.31.31.0-1.1-0.4-0.4
Seeking ratio, delayed vs. immediate footshock1.41.63.31.8-1.71.3-1.4-1.11.40.40.4
Distance traveled before self-admin1.21.33.2-0.31.8-0.80.91.1-1.7-0.9-0.9
Distance traveled after self-admin1.21.32.70.31.1-0.30.31.4-1.3-1.6-1.6
Extensor digitorum longus weight1.66.211.4-3.01.3-1.61.43.4-1.5-3.2-3.2
Bone: elastic displacement0.91.02.0-0.2-1.10.7-1.2-1.01.41.01.0
Bone: elastic work0.60.83.7-1.90.4-1.00.40.9-0.3-0.5-0.5
Bone: endosteal estimation1.32.84.7-0.81.5-1.11.12.1-1.8-2.2-2.2
Bone: endosteal perimeter1.73.66.8-1.12.5-1.81.71.9-2.6-1.5-1.5
Epididymis fat weight1.22.76.30.8-2.51.3-1.70.62.0-1.7-1.7
Delta time in closed arm before/after self-admin3.13.08.10.5-0.70.3-0.4-2.41.02.82.8
Delta time in open arm before/after self-admin0.20.20.50.1-0.60.5-0.70.20.5-0.5-0.5
Diff in mean of infusions in LGA sessions0.20.30.6-0.00.6-0.20.20.6-0.4-0.8-0.8
Delay discount exponential model param0.10.10.2-0.30.2-0.50.3-0.2-0.30.50.5
Extinction: sum of active levers before priming0.60.61.3-0.90.7-1.11.10.2-0.80.20.2
Active lever presses in extinction session 62.02.03.0-1.11.3-1.61.7-0.8-1.31.51.5
Bone: final force0.30.41.1-0.30.2-0.20.50.9-0.4-1.0-1.0
Bone: final moment0.30.51.1-0.40.2-0.40.60.9-0.4-1.0-1.0
Food consumed during 24 hour testing period0.30.30.6-0.2-0.20.8-0.60.40.4-0.7-0.7
Glucose0.30.52.1-1.40.3-0.70.90.10.10.50.5
Heart weight0.60.82.0-0.8-0.2-0.10.21.3-0.0-1.4-1.4
Delay discount hyperbolic model param0.20.20.4-0.40.3-0.70.5-0.3-0.40.60.6
Intermittent access intake day 1-15 change1.51.42.9-0.11.1-0.50.41.6-1.2-1.7-1.7
Intermittent access intake escalation2.22.13.6-0.51.6-1.00.81.9-1.7-1.8-1.8
Intermittent access intake escalation 23.93.96.0-1.02.4-1.61.52.4-2.3-2.0-2.0
Intermitt. access day 1 inactive lever presses0.30.30.60.4-0.50.3-0.2-0.80.50.80.8
Intermitt. access day 15 inactive lever presses0.10.10.20.1-0.3-0.1-0.1-0.40.40.40.4
Intermitt. access escalation Index0.50.40.60.3-0.70.8-0.70.30.8-0.7-0.7
Intermittent access day 1 total infusions0.60.71.80.1-0.40.2-0.2-1.20.51.31.3
Intermittent access day 15 total infusions0.20.30.7-0.30.9-0.50.40.4-0.8-0.2-0.2
Intermittent access terminal intake (last 3 days)0.20.20.5-0.60.7-0.50.50.4-0.6-0.1-0.1
Intermittent access total infusions0.30.40.8-0.60.5-0.50.3-0.4-0.40.90.9
Intermittent access day 1 locomotion0.40.51.0-0.50.6-0.50.5-0.5-0.61.01.0
Intermittent access day 15 total locomotion0.80.91.6-1.21.2-1.21.30.4-1.00.30.3
Intermittent access total locomotion1.31.52.5-1.51.3-1.61.5-0.0-1.30.90.9
Intermittent access standard deviation0.70.81.4-0.90.7-0.80.71.2-0.6-1.0-1.0
Left kidney weight0.82.23.5-1.91.4-1.71.51.5-1.4-1.2-1.2
Right kidney weight0.41.22.4-1.60.5-1.00.61.4-0.4-1.3-1.3
Cocaine induced anxiety1.31.44.2-0.00.20.3-0.21.7-0.4-2.1-2.1
Post-drug Anxiety0.10.20.40.5-0.10.7-0.3-0.40.10.40.4
Baseline Anxiety2.93.17.11.0-0.90.8-0.5-2.60.92.72.7
Tail length1.95.710.9-2.60.8-1.21.53.3-1.4-3.3-3.3
Length with tail5.720.732.2-5.43.5-4.14.05.7-3.7-4.8-4.8
Length without tail5.612.215.5-3.93.7-3.83.63.9-3.3-2.8-2.8
Times rat made contact with spout3.54.18.12.3-2.62.8-2.4-0.62.3-0.9-0.9
Lifetime Intake0.40.51.1-0.80.6-0.60.5-0.5-0.31.01.0
Liver weight, left0.10.10.2-0.40.1-0.40.2-0.4-0.10.50.5
Liver weight, right0.30.51.30.5-1.00.7-0.8-0.61.10.40.4
Locomotor activity12.319.533.4-5.84.5-5.45.04.0-4.5-2.4-2.4
Locomotor testing distance10.717.931.7-5.64.3-5.14.83.8-4.3-2.2-2.2
Locomotor testing rearing6.39.821.6-4.73.3-3.93.72.5-3.0-1.0-1.0
Locomotion in novel chamber0.20.31.01.0-0.40.9-0.6-0.30.2-0.1-0.1
Locomotion in novel chamber post-restriction1.01.22.61.60.50.5-0.4-1.4-0.71.31.3
Fecal boli incidents, locomotor time 14.24.68.4-2.01.7-1.51.92.9-1.5-2.6-2.6
Change in fecal boli incidents, locomotor task0.40.30.90.1-0.3-0.1-0.1-0.80.40.90.9
Time >=10cm from walls, locomotor time 11.01.02.30.8-1.51.2-1.1-0.41.4-0.2-0.2
Bouts of movement, locomotor time 10.50.61.50.5-0.31.2-1.0-0.60.70.60.6
Total resting periods, locomotor time 10.80.92.20.7-0.51.5-1.3-0.81.00.70.7
Rest time, locomotor task time 10.10.20.7-0.10.90.4-0.00.5-0.2-0.3-0.3
Distance moved, locomotor task time 10.30.30.60.1-0.80.1-0.5-0.70.70.70.7
Vertical activity count, locomotor time 10.20.30.6-0.8-0.3-0.20.00.60.1-0.7-0.7
Time >=10cm from walls, locomotor time 21.81.93.71.0-1.81.8-1.7-0.01.9-0.8-0.8
Bouts of movement, locomotor time 20.60.72.11.5-1.01.1-0.8-0.20.5-0.4-0.4
Total resting periods, locomotor time 20.91.02.71.6-1.21.4-1.0-0.40.8-0.3-0.3
Rest time, locomotor task time 20.30.41.40.4-0.41.2-0.70.10.7-0.4-0.4
Distance moved, locomotor task time 20.00.00.3-0.20.0-0.5-0.20.10.2-0.0-0.0
Vertical activity count, locomotor time 20.70.82.2-0.1-0.70.1-0.51.00.4-1.5-1.5
Light reinforcement 10.61.02.5-0.00.00.6-0.61.50.3-1.6-1.6
Light reinforcement 20.81.02.71.6-0.51.2-1.4-0.80.70.50.5
Bone: marrow area1.53.35.4-1.01.7-1.31.22.3-1.9-2.3-2.3
Bone: maximum diameter2.85.110.1-1.93.2-2.32.41.9-3.2-1.2-1.2
Bone: maximum force1.11.84.3-0.80.6-0.70.81.8-0.9-2.1-2.1
Bone: maximum moment1.11.94.1-0.90.6-0.80.91.8-0.9-2.0-2.0
Mean time between licks in bursts0.10.20.40.1-0.50.5-0.3-0.20.60.30.3
Mean num. licks in bursts1.11.32.60.3-1.60.9-0.80.61.3-1.5-1.5
Cd content in liver0.20.20.60.20.2-0.1-0.30.7-0.2-0.8-0.8
Co content in liver5.56.410.4-2.53.2-2.82.52.5-3.2-1.5-1.5
Cu content in liver0.30.30.80.9-0.40.6-0.90.10.3-0.5-0.5
Fe content in liver0.91.02.2-0.81.5-0.80.61.1-1.4-0.8-0.8
K content in liver0.70.71.91.40.70.00.5-0.9-0.80.90.9
Mg content in liver0.50.51.01.00.50.10.5-0.8-0.40.90.9
Mn content in liver0.70.83.61.90.30.8-1.10.2-0.4-0.6-0.6
Na content in liver0.30.30.7-0.50.6-0.80.8-0.1-0.60.30.3
Rb content in liver0.91.12.01.4-0.91.3-1.0-1.11.10.80.8
Se content in liver1.11.34.52.10.11.0-1.1-1.30.01.01.0
Sr content in liver0.30.30.40.0-0.60.3-0.3-0.70.60.60.6
Zn content in liver0.40.41.20.71.1-0.30.5-0.4-0.90.50.5
Bone: minimum diameter1.32.34.0-1.11.8-1.71.71.4-2.0-1.1-1.1
Time in familiar zone, hab. session 10.20.20.5-0.30.2-0.1-0.00.7-0.1-0.6-0.6
Time in novel zone, hab. session 10.30.30.70.1-0.1-0.20.2-0.8-0.00.90.9
Total zone transitions, hab. session 10.81.11.91.4-1.01.0-1.2-1.30.90.70.7
Total locomotion distance, hab. session 10.40.61.21.1-0.90.9-1.1-0.50.7-0.2-0.2
Locomotion velocity, hab. session 10.40.61.31.2-0.71.0-1.1-0.70.60.00.0
Time in familiar zone, hab. session 20.70.82.30.3-1.50.8-0.8-0.01.5-0.3-0.3
Time in novel zone, hab. session 21.11.13.1-0.81.8-1.01.00.3-1.70.20.2
Total zone transitions, hab. session 20.50.61.50.70.1-0.0-0.1-1.2-0.11.21.2
Total locomotion distance, hab. session 20.30.41.01.0-0.40.8-0.8-0.80.40.30.3
Locomotion velocity, hab. session 20.50.71.31.1-0.60.9-0.8-1.10.60.60.6
Novel to familiar place preference ratio0.50.51.71.30.00.5-0.1-0.9-0.20.70.7
Novelty place preference0.50.51.51.20.30.50.1-0.9-0.40.70.7
Time in novel zone, NPP test0.20.21.01.00.20.40.1-0.5-0.40.30.3
Total zone transitions, NPP test0.30.40.90.40.4-0.40.5-0.8-0.51.01.0
Total locomotion distance, NPP test0.10.10.80.9-0.10.3-0.0-0.5-0.00.10.1
Locomotion velocity, NPP test0.10.20.50.70.10.00.2-0.6-0.30.40.4
Intraocular pressure0.30.40.80.1-0.80.8-0.90.30.9-0.4-0.4
Delta distance traveled before/after self-admin0.40.51.11.1-0.70.6-0.60.10.5-0.7-0.7
Delta ambulatory time before/after self-admin0.80.91.51.0-0.80.9-0.90.50.6-1.2-1.2
Parametrial fat weight0.20.41.0-0.3-0.40.2-0.30.8-0.0-1.0-1.0
Pavlov. Cond. lever latency1.11.42.90.8-1.71.4-1.40.11.7-0.6-0.6
Pavlov. Cond. magazine entry latency0.81.02.01.4-1.21.2-0.9-1.01.10.50.5
Pavlov. Cond. change in total contacts0.10.10.20.30.10.2-0.20.1-0.2-0.4-0.4
Pavlov. Cond. index score0.20.20.50.60.10.2-0.0-0.7-0.20.60.6
Pavlov. Cond. latency score0.20.30.60.40.3-0.00.2-0.8-0.30.80.8
Pavlov. Cond. lever contacts0.60.71.5-0.81.2-1.01.10.1-1.20.20.2
Pavlov. Cond. magazine entry number0.91.22.1-1.20.9-0.90.81.5-0.8-1.2-1.2
Pavlov. Cond. intertrial magazine entries1.31.63.3-1.21.4-0.80.61.8-1.1-1.4-1.4
Pavlov. Cond. lever-magazine prob. diff.0.20.20.70.8-0.10.4-0.3-0.70.00.50.5
Pavlov. Cond. response bias0.30.40.90.7-0.40.5-0.3-1.00.40.70.7
Pavlov. Cond. lever latency1.41.95.72.4-1.11.6-1.5-1.40.80.80.8
Pavlov. Cond. magazine entry latency0.10.10.50.2-0.60.3-0.4-0.20.7-0.0-0.0
Pavlov. Cond. change in total contacts0.60.92.9-1.70.9-0.90.81.0-0.5-0.5-0.5
Pavlov. Cond. index score0.30.41.5-1.20.4-0.60.50.6-0.0-0.3-0.3
Pavlov. Cond. latency score0.10.20.6-0.80.2-0.40.20.50.1-0.3-0.3
Pavlov. Cond. lever contacts0.70.93.6-1.90.6-1.10.90.9-0.3-0.5-0.5
Pavlov. Cond. magazine entry number0.10.20.80.90.20.4-0.2-0.1-0.4-0.1-0.1
Pavlov. Cond. intertrial magazine entries0.81.03.30.31.8-0.71.10.4-1.80.00.0
Pavlov. Cond. lever-magazine prob. diff.0.20.31.4-1.20.3-0.50.40.60.1-0.4-0.4
Pavlov. Cond. response bias0.81.14.2-2.10.7-1.31.10.9-0.4-0.4-0.4
Time in closed arm before self-admin2.02.25.80.70.9-0.20.31.8-1.4-2.4-2.4
Time in closed arm after self-admin0.40.41.31.20.5-0.10.3-0.7-0.70.50.5
Time in open arm before self-admin0.50.61.1-0.6-0.7-0.0-0.2-0.71.01.01.0
Time in open arm after self-admin0.50.61.20.0-1.00.6-1.0-0.61.10.50.5
Bone: periosteal estimation1.42.94.0-1.31.8-1.51.61.9-2.0-1.7-1.7
Bone: periosteal perimeter1.72.94.7-1.12.0-1.72.01.7-2.2-1.4-1.4
Bone: post-yield work4.56.110.8-1.51.8-1.71.83.2-2.3-3.3-3.3
Progressive ratio test 1 active lever presses1.71.83.8-2.01.5-1.51.61.2-1.2-0.5-0.5
Progressive ratio test 1 breakpoint1.31.32.8-1.71.3-1.31.41.0-1.0-0.4-0.4
Progressive ratio test 1 inactive lever presses0.91.01.7-1.21.2-1.11.10.8-1.3-0.3-0.3
Progressive ratio test 2 active lever presses0.40.41.3-0.10.3-0.40.2-0.8-0.11.21.2
Progressive ratio test 2 breakpoint0.30.41.20.10.1-0.00.0-0.8-0.01.11.1
Progressive ratio test 2 inactive lever presses0.10.20.2-0.30.4-0.40.5-0.2-0.40.40.4
Incentive Sensitization - Responses0.50.51.00.7-0.20.2-0.4-1.00.41.01.0
Incentive Sensitization - Breakpoint0.40.40.80.7-0.30.3-0.5-0.90.40.90.9
Sum of active levers in priming session hrs 5-60.20.20.5-0.70.3-0.40.70.4-0.3-0.4-0.4
Progressive ratio0.70.81.51.0-0.91.1-1.2-0.71.20.40.4
Food seeking constrained by brief footshock0.91.12.31.3-1.11.3-1.50.11.0-0.8-0.8
Seeking ratio, punishment vs. effort0.20.20.60.1-0.10.1-0.00.6-0.2-0.8-0.8
Retroperitoneal fat weight0.20.62.2-0.5-1.5-0.0-0.30.31.4-0.5-0.5
Reaction time number correct1.42.14.1-2.00.7-1.81.31.7-0.8-1.4-1.4
Reaction time mean minus median0.50.72.11.4-0.10.8-1.2-0.9-0.00.60.6
Reaction time mean minus median AUC0.10.20.40.40.60.2-0.6-0.1-0.50.10.1
Reaction time num false alarms1.92.55.9-1.12.4-1.20.71.8-2.2-1.3-1.3
Reaction time num false alarms AUC1.01.43.2-0.51.8-0.70.01.4-1.6-1.1-1.1
Reaction time trials correct on left1.42.14.1-2.00.7-1.81.31.7-0.8-1.4-1.4
Reaction time trials on left1.52.14.1-2.00.7-1.81.31.7-0.8-1.4-1.4
Reaction time mean0.81.12.71.7-1.01.2-1.5-0.70.80.10.1
Reaction time mean AUC0.60.81.91.4-0.81.1-1.3-0.50.80.00.0
Median of all reaction times0.71.02.01.4-1.11.2-1.4-0.51.0-0.0-0.0
Reaction time omissions0.20.30.90.90.10.6-0.9-0.4-0.00.30.3
Reaction time false alarm rate0.50.72.50.11.6-0.1-0.20.7-1.4-0.5-0.5
Reaction time premature initiation rate0.40.61.4-0.60.7-0.40.8-0.5-0.21.21.2
Reaction time premature initiations0.60.92.1-1.51.0-1.21.30.5-0.60.30.3
Std. dev. reaction times1.52.14.42.1-1.01.4-1.9-1.60.91.11.1
Reaction time trials completed1.52.14.1-2.00.7-1.81.31.7-0.8-1.4-1.4
Reaction time trials AUC1.62.34.4-2.10.6-1.81.41.8-0.8-1.5-1.5
Run reversals in cocaine runway, females4.74.57.62.6-2.42.6-2.8-1.82.10.90.9
Run reversals in cocaine runway, males0.50.51.2-0.30.5-0.50.6-0.7-0.51.11.1
Latency to leave start box in cocaine runway1.11.22.00.6-1.40.7-0.6-1.41.21.21.2
Latency to leave start box in cocaine runway, F0.40.51.90.4-1.40.4-0.5-0.31.0-0.2-0.2
Latency to leave start box in cocaine runway, M1.81.74.50.5-0.50.5-0.3-1.90.52.12.1
Std. dev. time between licks in bursts0.10.10.20.30.40.1-0.1-0.0-0.30.40.4
Total sessions with >9 infusions0.50.62.2-1.50.3-0.80.8-0.2-0.10.70.7
Short access day 1 total inactive lever presses1.01.12.3-1.31.2-1.31.50.2-1.20.40.4
Short access day 10 total inactive lever presses0.40.50.90.90.50.3-0.30.7-0.4-1.0-1.0
Short access day 1 total infusions0.60.72.8-1.70.6-1.00.90.6-0.2-0.2-0.2
Short access day 10 total infusions0.80.91.6-1.10.8-0.90.9-0.6-0.51.31.3
Short access total infusions0.60.71.5-1.21.0-1.01.0-0.1-0.60.70.7
Short access day 1 locomotion1.21.32.7-1.61.0-1.51.5-0.0-0.90.80.8
Short access day 10 total locomotion0.80.91.5-1.21.1-1.21.10.1-1.20.40.4
Short access total locomotion1.81.83.7-1.91.5-1.81.90.6-1.30.20.2
One hour access (0.3 mA shock)0.40.40.8-0.90.8-0.40.20.8-0.7-0.5-0.5
Compulsive drug intake0.40.40.80.3-0.20.7-0.5-0.80.40.90.9
One hour access (shock baseline)0.10.10.2-0.50.3-0.50.30.5-0.3-0.3-0.3
Social response proportion1.51.74.4-0.1-2.11.3-0.30.62.0-1.2-1.2
Social responses1.21.53.3-0.90.5-0.60.41.8-0.7-1.8-1.8
Social time1.11.42.2-0.7-1.31.1-0.91.11.3-1.5-1.5
Soleus weight0.20.51.1-1.00.30.3-0.31.0-0.2-1.0-1.0
Bone: stiffness0.10.10.30.30.3-0.00.30.2-0.5-0.5-0.5
Tibialis anterior weight3.110.616.4-4.12.4-3.02.54.0-2.8-3.4-3.4
Time to tail flick, vehicle, before self-admin0.70.71.4-0.70.9-0.91.10.7-1.2-0.4-0.4
Time to tail flick, vehicle, after self-admin0.10.10.4-0.3-0.2-0.30.60.10.2-0.2-0.2
Time to tail flick, test, before self-admin0.70.71.9-0.30.30.00.31.20.2-1.4-1.4
Time to tail flick, test, after self-admin1.01.01.9-1.4-0.4-0.70.81.30.5-1.3-1.3
Delta time to tail flick, vehicle, before/after SA0.50.51.10.8-1.00.6-0.4-0.81.10.30.3
Delta time to tail flick, test, before/after SA0.70.62.6-0.0-1.60.5-0.7-0.11.3-0.3-0.3
Tibia length0.61.74.5-2.11.3-1.71.60.7-1.20.00.0
Ambulatory time before self-admin1.21.23.3-0.21.6-1.01.00.9-1.8-0.6-0.6
Ambulatory time after self-admin1.11.22.50.21.0-0.50.51.4-1.2-1.6-1.6
Bone: tissue strength0.40.41.0-0.7-0.4-0.20.40.70.3-1.0-1.0
Total heroin consumption0.30.41.6-1.30.4-0.70.4-0.20.20.60.6
Bone: trabecular number0.71.13.8-2.00.2-1.61.50.4-0.3-0.1-0.1
Bone: trabecular spacing1.41.83.61.9-1.21.7-1.8-0.91.30.30.3
Bone: trabecular thickness0.20.31.1-1.10.2-0.70.4-0.2-0.20.50.5
Bone: trabecular tissue density1.31.84.82.2-0.81.9-1.6-1.21.10.60.6
Water consumed over 24 hours0.30.40.8-0.7-0.5-0.1-0.10.60.5-0.9-0.9
Number of responses in last shaping day0.30.30.80.20.3-0.30.3-0.6-0.60.90.9