Hub : Genes

Pnpla8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg isoform ratio XM_063261901.1 0.17 0.1 8.9e-04 0.14 0.09 0.11 0.11 1.8e-04 1.8e-03 6.8e-04 9.6e-04
2 Liver gene expression Pnpla8 0.05 0.03 3.0e-06 0.05 0.05 0.04 0.05 1.2e-06 2.1e-06 1.3e-05 5.9e-06
3 RMTg alternative TSS XM_063261901.1 0.16 0.09 8.5e-04 0.17 0.1 0.07 0.1 2.4e-05 1.3e-03 5.7e-03 1.5e-03
4 RMTg alternative TSS XM_063261901.1 0.16 0.09 9.1e-04 0.16 0.1 0.07 0.1 6.2e-05 1.4e-03 5.0e-03 1.2e-03
5 Brain gene expression Pnpla8 0.09 0.05 1.3e-07 0.07 0.09 0.1 0.1 3.4e-07 4.6e-09 1.8e-09 3.0e-09
6 PL gene expression Pnpla8 0.23 0.13 3.2e-07 0.06 0.06 0.08 0.07 3.9e-07 1.5e-07 5.8e-09 1.1e-07
7 OFC gene expression Pnpla8 0.18 0.1 1.1e-03 0.14 0.06 0.08 0.1 3.1e-04 1.6e-02 6.6e-03 2.2e-03
8 LHb gene expression Pnpla8 0.22 0.14 7.2e-03 0.01 0.09 0.1 0.06 1.4e-01 4.5e-03 2.1e-03 1.5e-02
9 pVTA gene expression Pnpla8 0.05 0.04 5.7e-03 0.05 0.02 0.04 0.04 7.6e-05 4.7e-03 3.6e-04 2.2e-04
10 NAcc gene expression Pnpla8 0.11 0.05 9.7e-10 0.07 0.06 0.05 0.07 2.3e-10 1.1e-09 2.0e-08 2.9e-10
11 IC gene expression Pnpla8 0.26 0.16 6.6e-03 0.05 0.01 0.02 -0 5.4e-03 1.1e-01 4.9e-02 4.4e-01
12 BLA gene expression Pnpla8 0.08 0.05 2.5e-04 -0 0.04 0.01 0.01 3.6e-01 3.8e-03 8.5e-02 9.1e-02
13 Adipose gene expression Pnpla8 0.19 0.08 1.3e-15 0.11 0.1 0.1 0.1 6.3e-12 2.7e-11 4.7e-11 2.4e-11
14 Adipose mRNA stability Pnpla8 0.11 0.05 1.1e-10 0.08 0.07 0.07 0.07 3.2e-09 5.3e-08 3.0e-08 3.1e-08
15 Adipose isoform ratio XM_063261902.1 0.04 0.03 3.8e-03 0.01 0.01 0 0 9.1e-03 4.8e-02 1.6e-01 8.1e-02
16 PL alternative TSS NM_001108020.2 0.03 0.02 7.2e-03 0 0.01 0.01 0 1.3e-01 1.0e-02 3.3e-02 1.1e-01
17 Adipose isoform ratio XM_063261901.1 0.09 0.04 1.3e-08 0.05 0.06 0.06 0.06 2.6e-06 6.1e-07 1.7e-07 2.2e-07
18 Adipose alternative TSS XM_063261901.1 0.08 0.04 2.0e-07 0.06 0.04 0.04 0.05 1.9e-07 1.2e-05 4.2e-05 4.8e-06
19 Adipose alternative TSS XM_063261901.1 0.08 0.04 2.0e-07 0.06 0.04 0.04 0.05 1.9e-07 1.2e-05 4.1e-05 5.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bone: apparent density0.91.55.81.21.20.60.61.72.41.21.11.51.71.60.51.41.21.20.3-0.7-0.2-0.2
Area under the delay curve0.20.30.6-0.3-0.3-0.4-0.40.30.2-0.3-0.1-0.2-0.5-0.30.10.80.80.80.7-0.8-0.7-0.7
BMI with tail0.51.87.1-1.2-1.2-2.7-2.7-0.61.4-0.3-1.7-0.7-0.6-0.7-2.3-0.0-0.1-0.1-2.20.20.30.3
BMI without tail0.41.13.9-0.0-0.0-0.7-0.71.12.00.30.10.0-0.2-0.3-1.51.61.41.4-1.0-1.3-1.2-1.2
Body weight1.25.314.51.71.70.70.73.23.81.91.91.71.61.50.03.43.33.30.6-2.9-2.5-2.5
Weight adjusted by age0.30.41.10.30.30.30.30.90.90.20.70.20.20.3-0.11.11.11.10.2-0.9-0.7-0.7
Bone surface1.83.36.31.91.91.51.52.52.41.81.92.02.12.01.22.21.91.91.2-1.5-1.0-1.0
Bone volume1.01.86.61.41.41.01.01.82.61.31.31.51.71.60.51.71.41.40.3-0.8-0.2-0.2
Breakpoint value in progressive ratio session2.53.05.02.02.01.61.62.22.22.11.82.22.02.11.31.41.41.41.0-1.3-1.2-1.2
Number of licking bursts0.20.31.9-0.5-0.5-0.3-0.3-0.6-1.4-0.7-0.5-0.8-0.8-0.70.3-0.3-0.5-0.50.50.2-0.1-0.1
Context. condit. distance diff. score0.70.81.41.21.21.11.10.90.40.81.11.01.11.10.40.50.70.70.3-0.9-1.0-1.0
Locomotion velocity, session 11.11.21.8-1.0-1.0-0.7-0.7-1.2-0.8-0.9-1.0-0.7-1.0-1.0-1.1-1.3-1.1-1.1-1.31.31.41.4
Locomotion distance, session 10.50.61.5-0.8-0.8-0.7-0.7-1.0-1.2-0.6-0.4-1.0-0.8-0.8-0.5-0.7-0.6-0.6-0.50.70.80.8
Locomotion velocity, session 20.70.81.9-0.7-0.7-0.7-0.7-1.4-1.0-0.8-0.5-0.9-1.0-1.0-0.1-1.2-1.1-1.1-0.21.11.01.0
Locomotion distance, session 20.50.72.1-0.6-0.6-0.4-0.4-1.2-1.5-0.3-0.5-0.7-0.8-0.7-0.3-1.1-1.0-1.0-0.51.01.01.0
Locomotion velocity, session 30.40.51.40.40.40.50.50.8-0.30.61.00.20.30.30.90.70.80.81.2-0.8-0.8-0.8
Locomotion distance, session 31.41.52.51.01.00.80.81.60.51.41.40.91.21.21.31.21.31.31.5-1.5-1.6-1.6
Stereotopy head waving bouts, day 30.91.12.6-1.5-1.5-1.2-1.2-0.9-0.8-1.6-1.1-1.5-1.4-1.4-1.3-0.4-0.2-0.2-0.80.20.30.3
Stereotopy head waving duration, day 30.60.71.2-0.9-0.9-0.4-0.4-1.0-0.7-1.1-0.8-0.9-0.9-0.8-0.3-0.9-0.8-0.8-0.40.91.01.0
Locomotion velocity, session 71.11.23.00.10.1-0.2-0.21.20.70.20.60.50.70.61.21.51.41.41.7-1.6-1.7-1.7
Locomotion distance, session 71.92.46.00.10.1-0.2-0.21.81.40.41.00.50.70.51.12.32.32.32.0-2.4-2.5-2.5
Stereotopy head waving bouts, day 70.10.10.2-0.2-0.2-0.1-0.10.00.3-0.30.4-0.2-0.1-0.0-0.20.50.50.5-0.1-0.20.00.0
Stereotopy head waving duration, day 70.40.51.0-0.8-0.8-0.5-0.5-1.0-0.7-0.8-0.5-0.8-0.7-0.5-0.5-0.6-0.6-0.6-0.60.80.90.9
Locomotion velocity, session 82.42.98.4-0.2-0.20.30.3-2.3-2.2-0.4-1.2-0.5-0.4-0.4-0.5-2.9-2.7-2.7-1.52.62.32.3
Locomotion distance, session 80.40.51.11.01.01.01.0-0.2-0.80.90.50.80.80.80.3-0.8-0.7-0.7-0.30.60.50.5
Degree of sensitization distance0.20.20.40.10.1-0.1-0.10.40.6-0.20.20.30.20.00.40.60.50.50.7-0.5-0.5-0.5
Degree of sensitization stereotypy0.20.20.60.60.60.70.70.00.20.50.80.40.50.50.30.00.00.00.00.20.40.4
Conditioned locomotion7.89.016.4-3.5-3.5-2.9-2.9-3.2-3.0-3.8-2.9-3.9-4.1-4.0-3.2-2.0-1.8-1.8-2.62.02.12.1
Cocaine response after cond. corrected0.20.30.50.70.70.50.50.50.10.70.70.70.70.60.7-0.00.20.20.6-0.3-0.5-0.5
Cocaine response after cond. not corrected0.40.40.90.70.70.20.20.70.60.90.70.90.90.80.70.20.40.40.6-0.6-0.6-0.6
Cocaine response before conditioning1.41.74.20.30.3-0.3-0.31.61.70.60.90.60.60.60.81.92.02.01.5-1.9-1.7-1.7
Saline control response1.41.94.50.70.70.80.81.90.80.61.20.60.50.60.61.82.02.01.3-2.1-2.1-2.1
Bone: connectivity density1.52.47.61.71.71.21.21.92.81.71.32.22.32.41.21.21.11.10.7-0.7-0.3-0.3
Bone: cortical apparent density0.70.91.6-1.1-1.1-1.2-1.2-1.1-0.5-1.3-1.1-0.8-0.9-0.9-1.1-1.0-1.0-1.0-1.10.70.30.3
Bone: cortical area1.42.14.92.22.22.22.21.21.42.21.71.81.61.41.00.50.50.50.5-0.3-0.1-0.1
Bone: cortical porosity0.20.21.30.10.10.10.1-0.6-1.10.4-0.4-0.3-0.4-0.4-0.1-0.7-0.6-0.6-0.30.50.40.4
Bone: cortical porosity0.20.20.70.70.70.80.80.2-0.60.80.40.30.10.00.40.00.10.10.4-0.2-0.3-0.3
Bone: cortical thickness0.30.51.51.01.00.90.9-0.00.71.20.20.90.70.5-0.1-0.7-0.5-0.5-0.80.60.60.6
Bone: cortical thickness1.11.33.0-0.7-0.7-0.7-0.7-1.5-0.8-0.4-1.2-0.6-0.6-0.9-1.1-1.7-1.7-1.7-1.51.51.21.2
Bone: cortical tissue density0.70.91.6-1.1-1.1-1.2-1.2-1.1-0.5-1.3-1.1-0.7-0.9-0.8-1.0-1.0-1.0-1.0-1.00.60.30.3
Condit. Reinf. active minus inactive responses3.13.45.82.32.32.42.42.00.42.12.22.02.12.12.41.00.90.92.1-1.0-1.1-1.1
Condit. Reinf. active-inactive response ratio2.42.53.91.61.61.61.62.00.71.21.81.41.61.61.81.51.41.41.9-1.6-1.7-1.7
Condit. Reinf. active responses4.25.211.53.23.23.43.41.90.43.12.62.82.82.82.80.20.20.22.0-0.2-0.2-0.2
Condit. Reinf. inactive responses1.51.83.51.71.71.91.9-0.1-0.31.80.81.31.11.10.9-1.4-1.3-1.3-0.21.41.51.5
Incentive salience index mean4.25.110.33.13.13.23.21.90.63.02.52.82.82.83.00.40.30.32.2-0.3-0.3-0.3
Condit. Reinf. lever presses3.04.28.12.82.82.82.81.50.72.82.02.82.72.72.9-0.0-0.0-0.01.90.30.50.5
Condit. Reinf. active minus inactive responses0.81.13.41.41.41.41.40.4-0.51.21.11.11.11.21.8-0.4-0.4-0.41.40.20.00.0
Condit. Reinf. active-inactive response ratio0.20.30.90.60.60.50.50.2-0.90.30.80.1-0.0-0.00.9-0.1-0.2-0.21.00.0-0.2-0.2
Condit. Reinf. active responses1.31.85.81.71.71.61.60.7-0.21.61.11.61.81.82.4-0.3-0.3-0.31.90.10.00.0
Condit. Reinf. inactive responses0.70.82.60.80.80.80.80.70.41.10.31.21.61.61.50.20.30.31.3-0.4-0.5-0.5
Condit. Reinf. lever presses0.81.12.01.21.21.11.11.21.41.30.81.41.41.41.30.60.70.71.0-0.4-0.1-0.1
Condit. Reinf. lever reinforcers received2.02.87.02.22.22.12.11.00.32.21.32.22.42.42.6-0.4-0.3-0.31.80.20.10.1
Conditioned reinforcement - actives1.22.14.32.02.02.12.11.60.61.81.61.51.61.51.80.60.60.61.5-0.6-0.5-0.5
Conditioned reinforcement - inactives1.92.86.52.22.22.52.51.91.21.72.41.61.51.41.61.01.01.01.4-0.9-0.8-0.8
Conditioned locomotion1.11.43.81.81.82.02.00.80.61.71.01.21.31.40.9-0.3-0.3-0.30.20.50.60.6
Patch foraging indifference point 0 sec2.34.26.72.52.52.22.22.31.32.62.12.52.22.32.61.31.21.22.3-1.4-1.6-1.6
Patch foraging indifference point AUC1.62.35.72.02.02.42.40.30.31.51.01.81.81.81.6-1.2-1.1-1.10.51.11.01.0
Delay disc. indifference point, 0s delay0.10.10.90.20.20.40.40.11.00.2-0.10.20.10.20.1-0.1-0.1-0.10.10.10.10.1
Delay disc. indifference point, 16s delay0.40.40.70.60.60.60.60.80.60.60.60.70.50.60.60.70.70.70.7-0.7-0.6-0.6
Delay disc. indifference point, 2s delay0.50.51.3-0.2-0.2-0.2-0.20.71.1-0.20.3-0.1-0.4-0.30.11.11.11.10.7-1.1-1.1-1.1
Delay disc. indifference point, 24s delay0.10.10.2-0.3-0.3-0.2-0.2-0.3-0.4-0.4-0.4-0.3-0.4-0.3-0.1-0.2-0.2-0.20.00.20.10.1
Delay disc. indifference point, 4s delay0.91.01.9-1.2-1.2-1.2-1.2-1.1-1.0-1.2-1.3-1.1-1.4-1.3-0.9-0.5-0.5-0.5-0.60.50.60.6
Delay disc. indifference point, 8s delay0.60.71.8-0.0-0.0-0.5-0.50.90.60.10.20.30.10.10.31.41.41.41.0-1.4-1.3-1.3
Indifference point function ln k0.81.33.5-0.7-0.7-1.2-1.21.01.2-0.20.1-0.6-0.5-0.6-0.61.91.81.80.3-1.7-1.5-1.5
Indifference point function log k0.81.33.5-0.7-0.7-1.2-1.21.01.2-0.20.1-0.6-0.5-0.6-0.61.91.81.80.3-1.7-1.5-1.5
Patch foraging total patch changes 0 sec2.24.16.32.52.52.32.32.31.42.52.02.42.12.12.41.41.31.32.2-1.5-1.6-1.6
Patch foraging total patch changes 12 sec1.31.63.81.91.91.91.90.7-0.11.71.21.71.41.41.6-0.4-0.5-0.51.00.2-0.0-0.0
Patch foraging total patch changes 18 sec0.91.32.61.31.31.61.61.10.71.10.91.31.01.01.60.60.70.71.6-0.9-1.1-1.1
Patch foraging total patch changes 24 sec1.01.64.21.81.81.81.80.70.21.61.31.61.41.32.1-0.4-0.3-0.31.50.1-0.1-0.1
Patch foraging total patch changes 6 sec2.33.57.42.72.72.52.51.30.92.41.52.72.62.62.5-0.3-0.3-0.31.40.1-0.1-0.1
Patch foraging time to switch 0 sec4.28.615.7-3.9-3.9-4.0-4.0-2.9-2.0-3.7-3.3-3.4-3.5-3.7-3.6-1.0-1.1-1.1-2.71.11.01.0
Patch foraging water rate 0 sec2.65.59.22.52.52.22.23.02.62.42.72.22.22.32.12.32.32.32.1-2.1-2.0-2.0
Patch foraging water rate 12 sec2.34.77.12.72.72.32.32.62.42.62.42.52.42.41.81.71.71.71.5-1.6-1.5-1.5
Patch foraging water rate 18 sec0.50.81.40.80.80.50.51.20.90.80.90.70.70.70.31.11.11.10.5-1.1-1.1-1.1
Patch foraging water rate 24 sec0.60.92.30.50.5-0.0-0.01.31.20.90.70.80.40.4-0.11.51.51.50.1-1.3-1.0-1.0
Patch foraging water rate 6 sec1.11.63.81.71.71.61.61.31.32.01.21.71.61.70.70.30.40.40.2-0.5-0.6-0.6
Seeking ratio, delayed vs. immediate footshock0.91.24.0-1.6-1.6-2.0-2.0-0.9-0.5-1.1-1.0-1.2-1.2-1.1-1.0-0.1-0.1-0.1-0.50.10.00.0
Distance traveled before self-admin1.01.44.10.60.61.21.21.3-0.10.01.60.20.30.21.51.41.41.42.0-1.4-1.3-1.3
Distance traveled after self-admin1.51.84.60.60.61.21.21.4-0.90.12.1-0.2-0.0-0.01.21.71.71.71.9-1.8-1.7-1.7
Extensor digitorum longus weight1.76.815.32.32.32.42.43.63.92.13.11.31.51.30.83.53.53.51.5-2.9-2.2-2.2
Bone: elastic displacement0.60.71.7-0.7-0.7-0.9-0.9-1.0-0.2-0.5-0.8-0.9-0.8-0.8-1.3-0.9-0.8-0.8-1.30.60.50.5
Bone: elastic work0.70.93.31.21.20.80.81.01.81.11.00.90.90.80.20.70.70.70.1-0.8-0.9-0.9
Bone: endosteal estimation1.22.65.31.41.41.61.62.00.61.12.30.90.80.71.52.22.02.02.0-1.8-1.5-1.5
Bone: endosteal perimeter1.83.98.22.42.42.42.42.10.72.32.91.91.71.62.61.51.41.42.5-1.3-1.2-1.2
Epididymis fat weight1.13.78.7-1.5-1.5-2.4-2.41.41.7-1.1-0.2-1.2-1.1-1.1-1.42.93.03.00.2-2.7-2.3-2.3
Delta time in closed arm before/after self-admin3.23.07.5-0.1-0.1-0.4-0.4-2.0-0.30.4-1.80.30.30.3-0.8-2.7-2.7-2.7-2.12.72.72.7
Delta time in open arm before/after self-admin0.50.50.9-0.5-0.5-0.2-0.20.3-0.5-1.00.4-0.9-0.9-0.8-0.60.90.90.90.0-0.9-0.9-0.9
Diff in mean of infusions in LGA sessions0.10.10.30.30.3-0.1-0.10.4-0.30.50.40.2-0.2-0.20.40.60.60.60.5-0.5-0.3-0.3
Delay discount exponential model param0.20.30.50.60.60.60.6-0.10.10.60.40.50.70.60.1-0.6-0.6-0.6-0.50.50.50.5
Extinction: sum of active levers before priming0.80.92.61.21.20.70.70.61.21.60.61.51.51.50.8-0.1-0.1-0.10.10.20.30.3
Active lever presses in extinction session 61.81.83.11.61.61.31.3-0.20.61.80.51.71.51.50.8-1.4-1.4-1.4-0.51.61.71.7
Bone: final force0.50.81.50.90.90.70.71.21.10.71.20.60.80.50.31.11.21.20.5-1.1-1.0-1.0
Bone: final moment0.60.91.61.01.00.70.71.21.20.81.30.60.80.60.21.11.21.20.4-1.1-0.9-0.9
Food consumed during 24 hour testing period0.40.51.6-0.5-0.50.10.10.0-0.4-1.00.0-1.0-1.3-1.2-0.50.80.70.70.1-0.8-0.7-0.7
Glucose0.61.02.91.01.00.40.4-0.30.70.9-0.31.11.71.6-0.4-1.3-1.2-1.2-1.50.80.50.5
Heart weight0.50.82.50.80.80.60.61.31.60.81.00.50.40.3-0.51.31.31.3-0.3-0.8-0.2-0.2
Delay discount hyperbolic model param0.30.30.50.60.60.60.6-0.10.10.50.40.40.70.6-0.0-0.6-0.6-0.6-0.60.60.60.6
Intermittent access intake day 1-15 change1.32.75.71.31.31.41.42.11.31.12.41.11.21.21.71.91.91.92.0-1.9-1.9-1.9
Intermittent access intake escalation1.02.04.71.11.11.41.41.70.90.92.20.81.01.01.61.51.51.51.9-1.6-1.5-1.5
Intermittent access intake escalation 22.93.37.11.61.61.91.92.10.91.22.41.31.41.52.41.81.81.82.7-1.9-1.9-1.9
Intermitt. access day 1 inactive lever presses0.41.33.60.20.20.10.1-1.2-0.60.2-0.70.30.30.2-0.4-1.8-1.8-1.8-1.31.91.91.9
Intermitt. access day 15 inactive lever presses0.10.30.7-0.1-0.1-0.4-0.4-0.60.40.1-0.70.30.30.3-0.3-0.8-0.8-0.8-0.70.70.70.7
Intermitt. access escalation Index1.11.53.2-1.7-1.7-1.7-1.7-0.8-0.7-1.6-1.4-1.8-1.8-1.7-1.50.10.10.1-0.8-0.2-0.2-0.2
Intermittent access day 1 total infusions1.32.24.3-0.8-0.8-1.0-1.0-1.8-1.0-0.9-1.4-0.9-1.0-1.0-1.4-1.8-1.8-1.8-1.82.02.12.1
Intermittent access day 15 total infusions0.10.10.2-0.0-0.00.20.2-0.3-0.3-0.30.3-0.3-0.3-0.3-0.1-0.3-0.3-0.3-0.20.40.40.4
Intermittent access terminal intake (last 3 days)0.10.10.30.30.30.50.5-0.20.0-0.00.3-0.10.00.0-0.2-0.4-0.4-0.4-0.50.40.40.4
Intermittent access total infusions0.81.02.3-0.1-0.10.20.2-1.1-0.6-0.3-0.5-0.4-0.5-0.5-0.9-1.4-1.4-1.4-1.41.51.51.5
Intermittent access day 1 locomotion0.81.03.10.20.20.20.2-1.1-0.60.1-0.3-0.0-0.1-0.1-0.3-1.6-1.6-1.6-1.01.71.81.8
Intermittent access day 15 total locomotion0.20.30.80.80.80.90.90.20.40.70.40.60.60.80.3-0.3-0.3-0.3-0.10.40.40.4
Intermittent access total locomotion0.60.71.51.01.01.01.0-0.30.30.80.30.70.70.80.0-1.0-1.0-1.0-0.81.11.21.2
Intermittent access standard deviation0.40.92.71.01.01.01.01.11.70.81.10.90.80.80.80.80.80.80.9-0.8-0.7-0.7
Left kidney weight0.73.35.02.02.02.02.02.22.01.71.81.81.71.71.21.91.91.91.2-1.8-1.5-1.5
Right kidney weight0.52.36.20.70.70.40.42.02.30.61.00.60.50.5-0.02.52.42.40.6-2.2-1.9-1.9
Cocaine induced anxiety1.01.54.6-0.0-0.0-0.1-0.11.10.10.00.9-0.2-0.3-0.31.01.61.61.62.1-1.9-2.1-2.1
Post-drug Anxiety0.30.31.40.70.70.70.70.3-0.30.60.60.40.30.31.2-0.0-0.0-0.01.2-0.1-0.3-0.3
Baseline Anxiety1.61.95.60.80.80.50.5-0.90.21.1-0.61.01.01.00.1-2.0-2.0-2.0-1.32.22.42.4
Tail length2.610.118.92.62.63.23.24.32.82.03.71.81.61.51.64.44.24.22.6-4.0-3.7-3.7
Length with tail3.916.928.74.14.14.34.35.44.03.54.73.53.23.12.94.74.64.63.5-4.4-4.0-4.0
Length without tail1.13.56.91.81.81.51.52.42.61.71.71.81.81.81.32.12.22.21.4-2.0-1.7-1.7
Times rat made contact with spout3.03.57.5-2.6-2.6-2.2-2.2-1.0-1.1-2.6-1.4-2.6-2.7-2.7-2.10.90.90.9-0.7-0.9-0.9-0.9
Lifetime Intake0.60.82.00.40.40.50.5-0.8-0.30.1-0.3-0.0-0.0-0.0-0.6-1.3-1.3-1.3-1.31.41.41.4
Liver weight, left0.30.62.0-0.7-0.7-1.1-1.1-0.21.2-0.4-1.0-0.5-0.5-0.4-1.40.30.20.2-1.2-0.2-0.2-0.2
Liver weight, right0.91.64.7-1.5-1.5-1.8-1.8-0.90.1-1.6-1.6-1.2-1.3-1.2-2.2-0.2-0.3-0.3-1.80.30.40.4
Locomotor activity10.416.326.94.94.94.64.64.44.84.84.05.15.25.24.12.42.42.43.2-2.2-2.0-2.0
Locomotor testing distance6.812.323.04.24.23.93.93.84.34.23.14.54.84.83.81.81.81.82.8-1.8-1.6-1.6
Locomotor testing rearing3.97.816.33.43.43.53.52.83.63.22.13.83.84.02.81.11.11.11.8-1.2-1.3-1.3
Locomotion in novel chamber0.10.20.8-0.6-0.6-0.2-0.2-0.2-0.9-0.6-0.2-0.6-0.7-0.6-0.40.10.10.1-0.3-0.00.10.1
Locomotion in novel chamber post-restriction0.40.72.00.00.00.30.3-1.0-1.4-0.10.0-0.2-0.2-0.30.9-1.2-1.2-1.20.41.31.31.3
Fecal boli incidents, locomotor time 13.34.88.21.71.72.22.22.92.11.52.61.51.41.51.62.62.62.62.1-2.6-2.6-2.6
Change in fecal boli incidents, locomotor task0.40.40.80.00.0-0.5-0.5-0.7-0.30.2-0.80.10.2-0.1-0.1-0.9-0.9-0.9-0.40.90.90.9
Time >=10cm from walls, locomotor time 10.91.02.4-1.4-1.4-1.2-1.2-0.6-0.5-1.2-1.1-1.5-1.4-1.2-1.40.20.20.2-0.9-0.2-0.2-0.2
Bouts of movement, locomotor time 10.60.62.0-0.4-0.40.40.4-0.8-1.4-0.8-0.5-1.3-1.1-1.1-0.9-0.6-0.6-0.6-0.90.60.60.6
Total resting periods, locomotor time 10.80.92.5-0.6-0.60.30.3-1.0-1.6-1.1-0.6-1.5-1.4-1.3-1.1-0.7-0.7-0.7-1.00.70.70.7
Rest time, locomotor task time 10.40.51.40.60.61.21.20.6-0.80.11.1-0.2-0.2-0.20.90.50.50.51.2-0.5-0.5-0.5
Distance moved, locomotor task time 10.40.61.9-0.4-0.4-1.2-1.2-0.70.10.1-1.40.10.10.1-0.7-0.7-0.7-0.7-1.00.80.70.7
Vertical activity count, locomotor time 10.10.31.60.10.1-0.6-0.60.51.30.6-0.20.40.40.5-0.40.60.60.6-0.3-0.6-0.6-0.6
Time >=10cm from walls, locomotor time 21.21.73.8-1.7-1.7-1.4-1.4-0.5-0.6-1.9-1.1-1.9-1.9-1.9-1.70.80.80.8-0.6-0.8-0.8-0.8
Bouts of movement, locomotor time 20.50.82.1-1.4-1.4-1.1-1.1-0.3-0.7-1.3-1.0-1.1-1.1-0.8-0.40.60.60.60.2-0.6-0.6-0.6
Total resting periods, locomotor time 20.61.12.8-1.7-1.7-1.4-1.4-0.5-0.8-1.6-1.2-1.3-1.3-1.1-0.70.50.40.4-0.1-0.5-0.5-0.5
Rest time, locomotor task time 20.20.30.9-0.5-0.5-0.2-0.2-0.0-0.6-0.9-0.1-0.8-0.8-0.8-0.60.50.40.4-0.1-0.5-0.5-0.5
Distance moved, locomotor task time 20.00.00.10.10.1-0.2-0.2-0.00.30.3-0.20.20.20.30.1-0.1-0.1-0.1-0.00.10.10.1
Vertical activity count, locomotor time 20.70.92.3-0.6-0.6-0.7-0.70.81.0-0.10.3-0.4-0.4-0.2-0.21.51.51.50.6-1.5-1.5-1.5
Light reinforcement 10.71.76.1-0.5-0.5-0.1-0.11.0-0.0-0.80.3-0.6-0.6-0.60.61.71.71.71.8-2.1-2.5-2.5
Light reinforcement 20.60.92.8-1.4-1.4-0.6-0.6-1.1-1.7-1.4-0.8-1.3-1.3-1.2-0.0-0.6-0.5-0.50.40.40.20.2
Bone: marrow area1.43.05.81.51.51.81.82.10.71.22.41.11.00.91.72.32.12.12.2-1.9-1.7-1.7
Bone: maximum diameter3.66.714.93.63.63.93.92.41.63.43.43.02.62.43.11.01.01.02.4-0.8-0.5-0.5
Bone: maximum force1.42.54.41.61.61.31.32.02.11.42.01.31.41.10.62.02.02.00.9-1.7-1.4-1.4
Bone: maximum moment1.42.54.61.61.61.31.32.02.11.42.01.31.41.20.61.92.02.00.8-1.6-1.3-1.3
Mean time between licks in bursts0.10.21.0-0.1-0.10.20.2-0.1-1.0-0.3-0.2-0.4-0.4-0.4-0.8-0.4-0.2-0.2-0.80.0-0.2-0.2
Mean num. licks in bursts0.71.02.4-0.9-0.9-1.0-1.00.41.1-0.8-0.0-0.7-0.7-0.8-1.41.51.51.5-0.6-1.2-0.9-0.9
Cd content in liver0.20.21.2-0.6-0.6-0.8-0.80.21.1-0.3-0.3-0.10.20.1-0.30.40.40.4-0.1-0.4-0.3-0.3
Co content in liver4.45.18.32.72.72.92.92.51.62.62.72.22.62.72.61.31.41.42.2-1.5-1.6-1.6
Cu content in liver0.30.40.9-0.9-0.9-1.0-1.0-0.6-0.8-0.7-0.5-0.6-0.9-0.8-0.3-0.0-0.2-0.2-0.10.1-0.1-0.1
Fe content in liver1.11.34.50.90.91.21.20.9-0.00.71.40.80.60.61.80.80.80.82.1-1.2-1.5-1.5
K content in liver0.60.64.4-0.2-0.2-0.2-0.2-0.8-2.1-0.0-0.5-0.20.10.21.0-0.9-1.0-1.00.60.80.70.7
Mg content in liver0.30.33.2-0.1-0.10.10.1-0.3-1.80.1-0.1-0.00.10.20.8-0.5-0.5-0.50.60.30.00.0
Mn content in liver1.61.85.1-1.5-1.5-0.7-0.7-0.2-2.3-1.6-0.0-1.8-1.7-1.60.50.80.80.81.6-1.2-1.6-1.6
Na content in liver0.30.31.4-0.7-0.7-1.2-1.2-0.50.1-0.3-0.3-0.7-0.1-0.10.3-0.2-0.2-0.20.20.50.80.8
Rb content in liver1.21.44.6-1.6-1.6-1.2-1.2-0.9-2.2-1.7-1.1-2.0-1.6-1.5-1.10.1-0.1-0.1-0.50.0-0.1-0.1
Se content in liver0.40.53.0-0.4-0.4-0.2-0.2-0.8-1.7-0.40.1-0.7-0.3-0.41.3-0.6-0.7-0.71.40.2-0.2-0.2
Sr content in liver0.10.10.3-0.4-0.4-0.5-0.50.10.2-0.1-0.3-0.1-0.0-0.0-0.40.10.10.1-0.3-0.00.00.0
Zn content in liver0.40.41.40.50.50.70.7-0.4-1.10.50.40.30.30.31.2-0.8-0.9-0.90.80.60.30.3
Bone: minimum diameter1.42.64.82.22.22.12.11.60.92.22.11.71.41.41.81.21.01.01.6-0.9-0.8-0.8
Time in familiar zone, hab. session 10.20.20.50.20.20.30.30.70.30.00.30.10.30.40.10.60.60.60.2-0.7-0.7-0.7
Time in novel zone, hab. session 10.30.30.9-0.3-0.3-0.5-0.5-0.8-0.3-0.0-0.60.1-0.0-0.1-0.0-1.0-0.9-0.9-0.40.80.70.7
Total zone transitions, hab. session 10.81.21.8-1.3-1.3-1.2-1.2-1.3-1.1-1.3-1.2-0.9-1.2-1.2-0.8-0.8-0.7-0.7-0.70.91.11.1
Total locomotion distance, hab. session 10.30.51.2-1.0-1.0-1.0-1.0-0.6-0.4-1.0-0.5-0.6-1.0-1.1-0.40.30.20.20.0-0.10.10.1
Locomotion velocity, hab. session 10.30.41.5-0.6-0.6-0.6-0.6-0.6-0.6-0.7-0.2-0.7-1.1-1.2-0.40.0-0.0-0.0-0.00.20.50.5
Time in familiar zone, hab. session 20.70.82.4-1.1-1.1-1.4-1.4-0.30.4-0.7-1.1-0.8-0.9-0.8-1.60.30.20.2-1.1-0.2-0.3-0.3
Time in novel zone, hab. session 20.91.02.61.31.31.61.60.4-0.20.91.20.91.11.01.5-0.2-0.1-0.11.10.0-0.1-0.1
Total zone transitions, hab. session 20.50.72.8-0.3-0.30.10.1-1.1-1.7-0.5-0.6-0.0-0.3-0.20.2-1.3-1.2-1.2-0.21.11.11.1
Total locomotion distance, hab. session 20.30.42.3-0.5-0.5-0.1-0.1-0.8-1.5-0.7-0.1-0.5-0.9-0.9-0.1-0.4-0.4-0.40.00.50.60.6
Locomotion velocity, hab. session 20.40.62.5-0.5-0.5-0.2-0.2-1.1-1.6-0.7-0.3-0.5-0.9-1.0-0.3-0.7-0.7-0.7-0.20.80.80.8
Novel to familiar place preference ratio0.30.31.5-0.2-0.2-0.3-0.3-0.7-1.2-0.3-0.0-0.2-0.3-0.40.3-0.8-0.7-0.70.20.70.70.7
Novelty place preference0.30.31.70.10.1-0.0-0.0-0.7-1.3-0.10.2-0.1-0.2-0.30.5-0.8-0.7-0.70.40.70.70.7
Time in novel zone, NPP test0.10.11.10.10.10.00.0-0.4-1.0-0.10.3-0.1-0.2-0.30.5-0.4-0.3-0.30.50.30.30.3
Total zone transitions, NPP test0.30.41.30.00.00.30.3-0.7-1.10.1-0.20.20.20.30.7-1.1-0.9-0.90.31.01.01.0
Total locomotion distance, NPP test0.10.21.7-0.3-0.3-0.1-0.1-0.4-1.3-0.2-0.0-0.3-0.5-0.50.3-0.3-0.1-0.10.50.20.20.2
Locomotion velocity, NPP test0.10.21.7-0.0-0.00.10.1-0.5-1.30.10.1-0.0-0.2-0.20.5-0.6-0.4-0.40.40.50.50.5
Intraocular pressure0.20.30.9-0.5-0.50.00.00.2-0.1-0.4-0.3-0.6-0.9-1.0-1.00.40.30.3-0.4-0.7-0.9-0.9
Delta distance traveled before/after self-admin0.20.20.5-0.2-0.2-0.2-0.20.3-0.7-0.00.5-0.4-0.3-0.20.20.60.60.60.5-0.6-0.6-0.6
Delta ambulatory time before/after self-admin0.60.81.8-0.4-0.4-0.3-0.30.6-0.6-0.30.7-0.7-0.7-0.60.11.31.31.30.8-1.3-1.3-1.3
Parametrial fat weight0.81.94.51.11.11.01.02.12.11.41.31.21.01.00.21.91.81.80.3-1.6-1.3-1.3
Pavlov. Cond. lever latency0.91.12.6-1.1-1.1-1.1-1.1-0.1-0.1-1.6-0.5-1.3-1.2-1.3-1.60.70.80.8-0.8-1.0-1.1-1.1
Pavlov. Cond. magazine entry latency1.01.32.4-1.5-1.5-1.5-1.5-1.2-1.1-1.1-1.4-1.1-1.6-1.4-0.7-0.5-0.6-0.6-0.40.91.01.0
Pavlov. Cond. change in total contacts0.10.10.4-0.1-0.1-0.0-0.00.20.40.20.10.20.10.20.60.50.30.30.70.00.40.4
Pavlov. Cond. index score0.20.31.2-0.2-0.2-0.3-0.3-0.5-0.60.2-0.30.1-0.3-0.20.6-0.5-0.6-0.60.40.91.11.1
Pavlov. Cond. latency score0.30.31.3-0.0-0.0-0.1-0.1-0.5-0.50.5-0.20.2-0.00.10.7-0.7-0.8-0.80.41.01.11.1
Pavlov. Cond. lever contacts0.81.03.01.11.11.01.00.60.51.50.81.41.21.31.7-0.0-0.1-0.11.30.30.60.6
Pavlov. Cond. magazine entry number1.11.42.71.31.31.11.11.41.30.91.30.81.21.10.51.01.11.10.6-1.4-1.6-1.6
Pavlov. Cond. intertrial magazine entries1.72.03.31.51.51.71.71.81.11.21.70.91.11.01.21.31.41.41.4-1.5-1.6-1.6
Pavlov. Cond. lever-magazine prob. diff.0.20.20.8-0.3-0.3-0.3-0.3-0.4-0.60.1-0.2-0.1-0.3-0.30.6-0.3-0.4-0.40.50.70.90.9
Pavlov. Cond. response bias0.40.51.7-0.6-0.6-0.6-0.6-0.8-0.6-0.3-0.8-0.2-0.6-0.50.1-0.7-0.7-0.7-0.01.11.31.3
Pavlov. Cond. lever latency0.91.33.0-1.6-1.6-1.6-1.6-1.1-1.7-1.5-0.8-1.7-1.4-1.3-0.4-0.3-0.4-0.40.10.30.10.1
Pavlov. Cond. magazine entry latency0.20.20.5-0.6-0.6-0.6-0.6-0.40.3-0.5-0.7-0.4-0.4-0.4-0.7-0.3-0.1-0.1-0.60.30.40.4
Pavlov. Cond. change in total contacts0.40.61.91.01.01.41.40.60.90.80.21.10.90.80.20.00.20.2-0.0-0.2-0.2-0.2
Pavlov. Cond. index score0.20.20.70.60.60.80.80.30.90.50.10.70.50.4-0.1-0.10.10.1-0.40.10.20.2
Pavlov. Cond. latency score0.10.10.30.40.40.60.60.20.60.3-0.00.40.30.2-0.1-0.10.10.1-0.30.00.10.1
Pavlov. Cond. lever contacts0.50.72.51.11.11.11.10.91.61.00.41.31.00.90.00.30.50.5-0.3-0.4-0.2-0.2
Pavlov. Cond. magazine entry number0.20.20.9-0.1-0.1-0.2-0.20.2-0.7-0.20.5-0.3-0.4-0.30.60.50.30.30.9-0.5-0.6-0.6
Pavlov. Cond. intertrial magazine entries1.01.54.81.41.41.21.21.0-0.71.21.61.10.90.92.20.50.30.32.2-0.8-1.3-1.3
Pavlov. Cond. lever-magazine prob. diff.0.20.20.70.60.60.80.80.40.80.40.10.60.40.3-0.20.00.20.2-0.3-0.00.10.1
Pavlov. Cond. response bias0.81.13.21.51.51.31.31.01.81.40.51.71.41.30.20.20.40.4-0.3-0.3-0.1-0.1
Time in closed arm before self-admin2.53.27.7-0.4-0.4-0.3-0.31.7-0.1-0.61.6-0.6-0.6-0.51.22.82.82.82.7-2.8-2.7-2.7
Time in closed arm after self-admin0.10.20.7-0.1-0.1-0.5-0.5-0.3-0.50.3-0.20.20.00.20.8-0.3-0.3-0.30.70.40.40.4
Time in open arm before self-admin1.21.33.00.20.2-0.2-0.2-1.00.50.6-1.10.40.50.4-0.9-1.6-1.6-1.6-1.71.71.71.7
Time in open arm after self-admin0.40.41.4-0.5-0.5-0.2-0.2-0.6-0.5-0.9-0.3-0.9-0.7-0.7-1.2-0.3-0.3-0.3-1.20.40.50.5
Bone: periosteal estimation1.63.56.92.42.42.52.52.01.42.22.61.81.61.41.71.71.51.51.7-1.3-1.0-1.0
Bone: periosteal perimeter2.23.87.32.32.32.42.42.01.12.42.71.91.81.62.21.51.51.52.2-1.4-1.3-1.3
Bone: post-yield work4.26.210.62.12.12.02.03.32.42.12.91.82.02.02.13.03.13.12.7-2.8-2.5-2.5
Progressive ratio test 1 active lever presses0.91.13.31.61.61.81.81.11.01.11.11.31.21.10.70.30.30.30.2-0.10.00.0
Progressive ratio test 1 breakpoint0.81.03.21.51.51.81.81.01.01.11.01.31.11.10.70.20.20.20.2-0.10.10.1
Progressive ratio test 1 inactive lever presses0.91.33.41.61.61.81.80.50.51.31.11.51.31.31.1-0.4-0.4-0.40.40.50.60.6
Progressive ratio test 2 active lever presses0.40.51.0-0.4-0.4-0.3-0.3-0.9-0.6-0.4-0.7-0.5-0.5-0.6-0.5-0.8-0.8-0.8-0.71.01.01.0
Progressive ratio test 2 breakpoint0.50.61.3-0.3-0.3-0.3-0.3-0.9-0.7-0.4-0.7-0.5-0.5-0.6-0.5-1.0-1.0-1.0-0.81.11.11.1
Progressive ratio test 2 inactive lever presses0.10.20.5-0.4-0.4-0.4-0.4-0.6-0.2-0.5-0.5-0.4-0.4-0.5-0.2-0.5-0.5-0.5-0.20.60.70.7
Incentive Sensitization - Responses0.91.22.1-1.3-1.3-1.5-1.5-1.4-1.1-1.0-1.4-1.1-1.0-1.1-0.5-1.0-1.0-1.0-0.41.01.01.0
Incentive Sensitization - Breakpoint0.81.12.1-1.2-1.2-1.4-1.4-1.3-1.0-1.0-1.4-1.1-1.0-1.1-0.5-0.8-0.8-0.8-0.40.90.90.9
Sum of active levers in priming session hrs 5-60.50.51.20.70.70.60.60.91.10.70.70.80.60.60.20.80.80.80.2-0.7-0.6-0.6
Progressive ratio0.61.01.6-0.9-0.9-0.6-0.6-1.2-0.2-0.9-1.0-0.9-0.9-1.1-1.0-1.1-1.1-1.1-1.11.21.31.3
Food seeking constrained by brief footshock0.91.12.0-1.4-1.4-1.3-1.3-0.2-0.3-1.4-0.5-1.4-1.4-1.3-0.70.80.80.80.3-0.9-0.9-0.9
Seeking ratio, punishment vs. effort0.30.51.7-0.4-0.4-0.5-0.50.5-0.2-0.20.1-0.3-0.3-0.10.20.90.90.90.8-1.1-1.3-1.3
Retroperitoneal fat weight0.31.14.3-0.6-0.6-2.1-2.10.61.90.1-0.5-0.10.10.1-1.31.21.11.1-1.0-0.7-0.3-0.3
Reaction time number correct0.91.86.71.21.20.40.41.72.61.61.01.51.81.80.61.31.41.40.5-1.2-1.0-1.0
Reaction time mean minus median0.20.41.1-0.7-0.7-0.8-0.8-0.9-1.0-0.4-0.5-0.6-0.5-0.50.2-0.6-0.6-0.60.20.60.60.6
Reaction time mean minus median AUC0.00.10.60.20.20.10.1-0.1-0.30.30.20.10.20.20.8-0.2-0.1-0.10.7-0.1-0.3-0.3
Reaction time num false alarms2.23.18.91.71.71.91.91.70.41.72.21.31.31.32.81.21.21.23.0-1.6-1.9-1.9
Reaction time num false alarms AUC1.21.86.81.01.01.11.11.30.21.11.70.70.80.82.21.01.11.12.6-1.4-1.7-1.7
Reaction time trials correct on left0.91.86.71.21.20.40.41.72.61.61.01.51.81.80.61.31.41.40.5-1.2-1.0-1.0
Reaction time trials on left1.01.96.71.21.20.40.41.82.61.61.01.51.81.80.71.41.41.40.6-1.2-1.0-1.0
Reaction time mean0.71.12.8-1.7-1.7-1.3-1.3-1.0-1.0-1.5-1.4-1.5-1.2-1.1-0.5-0.1-0.1-0.1-0.00.20.20.2
Reaction time mean AUC0.50.92.2-1.5-1.5-1.3-1.3-0.9-0.8-1.4-1.3-1.4-1.0-1.0-0.5-0.1-0.1-0.1-0.00.10.10.1
Median of all reaction times0.81.23.1-1.8-1.8-1.3-1.3-0.9-0.8-1.7-1.4-1.6-1.4-1.2-0.70.00.00.0-0.1-0.00.00.0
Reaction time omissions0.20.31.0-0.6-0.6-0.3-0.3-0.0-0.5-0.70.3-0.8-0.5-0.60.60.30.40.41.0-0.3-0.2-0.2
Reaction time false alarm rate0.81.15.10.80.81.31.30.7-0.70.71.40.40.30.22.00.40.40.42.3-0.8-1.1-1.1
Reaction time premature initiation rate0.40.61.40.70.71.01.0-0.5-0.80.5-0.50.50.40.40.0-1.2-1.2-1.2-0.60.80.50.5
Reaction time premature initiations0.40.71.61.31.31.11.10.40.51.30.11.21.21.20.4-0.3-0.3-0.3-0.20.1-0.2-0.2
Std. dev. reaction times1.01.83.1-1.7-1.7-1.5-1.5-1.8-1.6-1.4-1.6-1.6-1.4-1.2-0.6-1.1-1.1-1.1-0.61.11.01.0
Reaction time trials completed1.01.96.71.21.20.40.41.82.61.61.01.51.81.80.71.41.41.40.6-1.2-1.0-1.0
Reaction time trials AUC1.01.96.61.11.10.40.41.82.61.51.01.51.71.80.61.51.51.50.6-1.4-1.1-1.1
Run reversals in cocaine runway, females4.54.57.8-2.7-2.7-2.2-2.2-2.3-2.3-2.8-2.1-2.8-2.7-2.6-2.5-1.1-1.1-1.1-2.01.11.11.1
Run reversals in cocaine runway, males0.50.51.20.50.50.40.4-0.50.30.60.50.60.60.40.1-1.1-1.1-1.1-0.61.11.01.0
Latency to leave start box in cocaine runway1.11.23.5-1.1-1.1-1.7-1.7-1.30.0-0.6-1.9-0.5-0.4-0.4-1.2-1.0-1.0-1.0-1.41.00.90.9
Latency to leave start box in cocaine runway, F0.40.52.4-0.7-0.7-1.6-1.60.11.1-0.1-0.80.10.20.2-0.40.40.40.4-0.1-0.4-0.4-0.4
Latency to leave start box in cocaine runway, M2.32.14.1-0.7-0.7-0.6-0.6-1.9-1.1-0.6-1.8-0.6-0.6-0.6-1.3-2.0-2.0-2.0-2.02.01.91.9
Std. dev. time between licks in bursts0.20.22.6-0.1-0.10.10.1-0.3-1.6-0.30.0-0.3-0.3-0.20.3-0.4-0.5-0.50.30.0-0.4-0.4
Total sessions with >9 infusions0.20.30.70.70.70.80.80.30.30.60.10.60.70.70.1-0.2-0.2-0.2-0.40.40.50.5
Short access day 1 total inactive lever presses1.62.13.41.71.71.81.8-0.10.71.50.31.71.81.80.8-1.5-1.5-1.5-0.61.61.61.6
Short access day 10 total inactive lever presses0.20.51.80.80.80.70.70.50.20.71.30.80.80.91.30.20.20.21.2-0.1-0.0-0.0
Short access day 1 total infusions0.60.81.91.21.21.11.11.11.41.30.41.11.11.10.10.60.60.6-0.3-0.4-0.2-0.2
Short access day 10 total infusions0.91.12.40.90.91.01.0-0.6-0.10.70.00.60.60.7-0.2-1.5-1.5-1.5-1.31.51.51.5
Short access total infusions0.60.71.61.31.31.31.30.30.61.10.50.90.90.90.2-0.5-0.5-0.5-0.50.60.80.8
Short access day 1 locomotion0.91.12.61.51.51.21.20.50.71.60.51.41.51.50.7-0.5-0.5-0.5-0.10.60.70.7
Short access day 10 total locomotion0.20.41.30.90.91.01.00.30.00.51.20.50.40.40.5-0.2-0.2-0.20.10.30.40.4
Short access total locomotion0.40.51.41.11.11.21.20.40.30.80.70.80.80.80.6-0.2-0.2-0.20.10.40.50.5
One hour access (0.3 mA shock)0.40.41.00.10.10.40.40.70.1-0.20.8-0.6-0.5-0.5-0.21.01.01.00.3-1.0-1.0-1.0
Compulsive drug intake1.11.33.6-1.0-1.0-0.8-0.8-1.2-0.7-1.1-1.2-1.4-1.3-1.3-1.9-0.9-0.9-0.9-1.90.80.80.8
One hour access (shock baseline)0.10.10.50.20.20.20.20.4-0.00.20.70.10.10.10.30.40.40.40.5-0.5-0.5-0.5
Social response proportion1.51.74.6-1.4-1.4-1.3-1.30.10.4-1.2-1.0-1.4-1.4-1.3-2.11.21.11.1-1.2-1.3-1.5-1.5
Social responses1.31.74.40.40.40.50.51.60.90.41.10.20.50.60.91.91.81.81.5-2.0-2.1-2.1
Social time0.81.12.5-0.3-0.3-0.1-0.10.80.9-0.40.2-0.8-1.0-1.1-1.41.41.51.5-0.4-1.6-1.6-1.6
Soleus weight0.30.92.80.80.81.71.71.21.60.61.2-0.20.0-0.1-0.41.21.21.2-0.3-0.60.10.1
Bone: stiffness0.20.30.80.90.90.60.60.40.50.70.80.50.50.2-0.00.40.30.3-0.2-0.10.00.0
Tibialis anterior weight3.612.225.53.83.83.53.54.45.03.84.03.43.12.92.13.63.63.62.3-3.2-2.7-2.7
Time to tail flick, vehicle, before self-admin0.30.30.90.90.90.60.60.5-0.30.90.80.60.60.60.90.00.00.00.7-0.1-0.1-0.1
Time to tail flick, vehicle, after self-admin0.10.10.5-0.1-0.1-0.4-0.4-0.2-0.10.3-0.70.30.20.30.1-0.2-0.2-0.2-0.10.50.60.6
Time to tail flick, test, before self-admin0.20.20.5-0.5-0.5-0.3-0.30.1-0.1-0.6-0.4-0.4-0.3-0.40.10.50.50.50.6-0.6-0.7-0.7
Time to tail flick, test, after self-admin0.50.51.4-0.6-0.6-0.5-0.50.30.6-0.4-0.7-0.4-0.5-0.2-1.20.80.80.8-0.8-0.9-0.9-0.9
Delta time to tail flick, vehicle, before/after SA1.00.92.7-1.0-1.0-1.2-1.2-1.1-0.3-0.7-1.6-0.4-0.5-0.5-1.0-0.7-0.7-0.7-1.21.01.11.1
Delta time to tail flick, test, before/after SA0.90.93.7-1.1-1.1-1.2-1.2-0.70.1-1.0-1.2-1.1-1.1-0.9-1.9-0.1-0.1-0.1-1.70.10.10.1
Tibia length0.41.13.71.61.61.91.90.70.90.90.91.11.31.30.80.30.20.20.4-0.3-0.4-0.4
Ambulatory time before self-admin0.60.92.80.80.80.90.91.1-0.00.51.30.80.80.61.51.01.01.01.7-0.9-0.8-0.8
Ambulatory time after self-admin1.51.84.10.60.61.11.11.5-0.60.31.90.10.30.31.41.81.81.82.0-1.7-1.6-1.6
Bone: tissue strength0.80.82.30.30.30.10.11.11.50.20.60.20.40.4-0.31.31.51.50.1-1.4-1.3-1.3
Total heroin consumption0.20.21.10.30.30.00.0-0.01.10.6-0.60.70.70.70.0-0.4-0.4-0.4-0.40.40.30.3
Bone: trabecular number0.50.84.10.90.90.30.30.92.01.00.51.31.51.50.20.50.40.4-0.40.20.60.6
Bone: trabecular spacing1.31.73.6-1.9-1.9-1.5-1.5-1.5-1.0-1.9-1.5-1.8-1.7-1.8-1.3-0.4-0.5-0.5-0.80.30.10.1
Bone: trabecular thickness0.30.41.00.70.70.80.80.31.00.70.40.50.90.8-0.0-0.1-0.3-0.3-0.60.60.90.9
Bone: trabecular tissue density1.11.65.2-1.2-1.2-1.0-1.0-1.6-2.3-1.5-0.9-1.6-1.6-1.8-1.2-0.8-1.0-1.0-1.00.80.50.5
Water consumed over 24 hours0.40.61.7-0.8-0.8-0.9-0.90.11.3-0.6-0.5-0.6-0.5-0.5-0.90.90.80.8-0.4-0.9-0.9-0.9
Number of responses in last shaping day0.60.71.61.01.00.80.80.1-0.11.20.31.00.91.01.1-0.7-0.7-0.70.40.91.11.1