Hub : Genes

Pnpla6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Pnpla6 0.19 0.09 1.6e-07 0.15 0.14 0.12 0.13 2.2e-08 7.9e-08 3.3e-07 2.8e-07
2 PL gene expression Pnpla6 0.07 0.04 2.5e-05 0.03 0.04 0.03 0.03 3.1e-04 7.8e-05 2.3e-04 7.2e-04
3 Brain isoform ratio XM_008769013.3 0.04 0.02 6.4e-05 0.07 0.06 0.03 0.06 6.5e-07 8.0e-06 7.5e-04 3.9e-06
4 Brain intron excision ratio chr12_1574557_1575660 0.03 0.02 3.2e-03 0.03 0.03 0.02 0.02 4.0e-04 9.0e-04 6.3e-03 2.5e-03
5 Adipose gene expression Pnpla6 0.04 0.02 1.1e-03 0.02 0.01 0.02 0.02 1.6e-03 1.3e-02 5.6e-03 4.3e-03
6 Brain gene expression Pnpla6 0.17 0.08 0.0e+00 0.19 0.2 0.2 0.2 4.3e-17 3.6e-18 1.7e-18 5.5e-18
7 pVTA mRNA stability Pnpla6 0.13 0.07 1.5e-04 0.1 0.08 0.07 0.1 4.6e-05 1.9e-04 7.5e-04 6.8e-05
8 pVTA gene expression Pnpla6 0.23 0.1 4.8e-08 0.11 0.17 0.15 0.16 1.2e-05 9.9e-08 6.1e-07 2.5e-07
9 Brain isoform ratio XM_008769008.3 0.05 0.03 1.2e-03 0.03 0.03 0.03 0.03 4.9e-04 8.8e-04 5.2e-04 4.1e-04
10 pVTA intron excision ratio chr12_1591675_1593637 0.18 0.1 7.2e-03 0.07 0.01 0.05 0.04 6.4e-04 7.7e-02 4.0e-03 6.6e-03
11 NAcc gene expression Pnpla6 0.16 0.07 7.1e-14 0.08 0.13 0.13 0.12 1.2e-09 7.0e-15 1.5e-14 7.2e-14
12 NAcc isoform ratio XM_039089893.1 0.04 0.03 3.2e-03 -0 0.02 0 0 9.3e-01 5.1e-03 1.5e-01 1.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.11.84.50.8-0.7-2.1-2.1-2.1-0.21.10.1-0.2-1.51.80.6
Area under the delay curve3.03.25.80.9-1.32.42.42.41.6-2.3-1.71.9-0.2-2.0-0.8
BMI with tail1.34.410.01.9-2.30.90.90.82.0-2.6-2.43.2-3.1-0.8-2.1
BMI without tail1.93.87.52.7-2.51.01.01.02.5-1.6-2.42.2-1.4-1.7-2.3
Body weight3.715.433.35.8-5.1-0.0-0.0-0.14.4-3.0-4.54.8-5.1-1.6-5.1
Weight adjusted by age0.60.71.8-0.20.3-1.3-1.3-1.3-0.60.70.6-0.4-0.61.0-0.1
Bone surface0.81.44.81.5-1.5-1.2-1.2-1.30.7-0.2-0.91.1-2.20.9-0.5
Bone volume0.81.43.80.5-0.8-1.6-1.6-1.7-0.10.3-0.10.4-2.01.70.5
Breakpoint value in progressive ratio session1.92.13.41.4-1.91.71.71.71.7-1.4-1.81.3-0.3-1.3-0.2
Number of licking bursts0.91.02.30.11.1-1.2-1.2-1.2-0.51.21.0-1.00.1-0.0-1.5
Context. condit. distance diff. score2.12.57.52.5-2.71.11.11.02.1-1.0-2.21.3-0.3-1.1-0.2
Locomotion velocity, session 10.40.40.90.1-0.31.01.01.00.5-0.6-0.50.30.6-0.70.1
Locomotion distance, session 10.20.31.1-0.60.40.50.50.5-0.20.10.3-0.51.1-0.30.7
Locomotion velocity, session 20.30.41.00.3-0.00.80.80.80.5-0.3-0.30.20.7-1.0-0.6
Locomotion distance, session 20.60.85.0-0.40.60.40.40.4-0.30.90.6-1.32.2-0.41.0
Locomotion velocity, session 30.30.30.90.7-1.00.50.50.50.8-0.5-0.80.60.0-0.40.2
Locomotion distance, session 30.50.61.2-0.40.4-0.7-0.7-0.7-0.61.00.7-0.90.70.71.1
Stereotopy head waving bouts, day 30.30.40.90.9-0.5-1.0-1.0-0.90.20.5-0.2-0.1-0.60.5-0.4
Stereotopy head waving duration, day 30.10.10.3-0.20.3-0.4-0.4-0.4-0.3-0.00.20.1-0.60.4-0.2
Locomotion velocity, session 72.12.33.70.7-0.91.91.91.91.4-1.8-1.41.7-0.4-1.9-1.3
Locomotion distance, session 71.01.32.41.0-1.01.51.51.51.2-0.8-1.10.60.8-1.5-0.2
Stereotopy head waving bouts, day 70.20.20.9-0.40.20.30.30.3-0.10.20.2-0.51.0-0.10.8
Stereotopy head waving duration, day 70.10.10.3-0.50.40.30.30.3-0.30.00.3-0.30.5-0.10.3
Locomotion velocity, session 80.80.91.30.8-0.81.01.00.91.1-1.0-1.01.1-0.3-1.1-1.1
Locomotion distance, session 80.81.22.71.6-1.60.90.90.91.5-0.8-1.41.0-0.2-1.1-0.5
Degree of sensitization distance0.90.92.10.3-0.31.41.41.40.7-0.9-0.70.60.4-1.5-0.8
Degree of sensitization stereotypy0.10.10.3-0.2-0.00.60.60.60.1-0.2-0.10.00.4-0.30.4
Conditioned locomotion0.60.71.8-0.70.4-1.0-1.0-0.8-1.00.60.7-0.6-0.01.31.2
Cocaine response after cond. corrected1.01.16.2-0.90.7-0.5-0.5-0.7-0.6-1.00.21.2-2.50.8-1.1
Cocaine response after cond. not corrected0.80.84.9-0.4-0.20.20.20.10.1-1.4-0.51.5-2.20.4-0.6
Cocaine response before conditioning1.41.63.81.3-1.91.41.41.41.5-0.5-1.40.41.0-0.91.3
Saline control response0.60.82.21.5-0.7-0.7-0.7-0.50.51.3-0.1-1.11.4-0.3-0.1
Bone: connectivity density0.81.33.41.9-1.5-1.4-1.4-1.50.80.6-0.70.3-1.30.8-0.3
Bone: cortical apparent density0.50.71.40.1-0.31.21.21.20.6-1.1-0.71.0-0.4-0.9-0.6
Bone: cortical area1.72.54.72.0-2.21.11.11.02.0-1.6-2.01.9-1.1-1.2-1.2
Bone: cortical porosity0.10.10.1-0.00.1-0.4-0.4-0.3-0.20.30.2-0.2-0.10.30.1
Bone: cortical porosity0.10.10.40.0-0.10.20.20.2-0.00.30.0-0.40.6-0.00.6
Bone: cortical thickness1.32.13.61.8-1.90.80.80.91.8-1.5-1.81.8-1.1-1.1-1.4
Bone: cortical thickness0.60.72.31.5-1.20.50.50.51.2-0.2-1.00.40.4-1.0-0.7
Bone: cortical tissue density0.40.51.0-0.1-0.11.01.01.00.4-1.0-0.50.8-0.3-0.8-0.5
Condit. Reinf. active minus inactive responses0.30.30.7-0.4-0.10.80.80.80.2-0.8-0.30.6-0.3-0.30.2
Condit. Reinf. active-inactive response ratio0.60.71.60.0-0.51.01.01.00.5-1.3-0.81.1-0.8-0.5-0.2
Condit. Reinf. active responses0.20.30.7-0.0-0.40.80.80.80.3-0.3-0.30.00.7-0.40.8
Condit. Reinf. inactive responses0.50.63.70.0-0.20.60.60.60.20.50.0-0.81.9-0.41.3
Incentive salience index mean0.20.21.0-0.3-0.30.70.70.70.1-0.3-0.20.10.4-0.11.0
Condit. Reinf. lever presses0.30.42.30.0-0.50.50.50.50.20.2-0.2-0.31.10.01.5
Condit. Reinf. active minus inactive responses2.73.45.62.3-2.01.91.91.72.4-1.2-2.11.30.3-2.4-1.6
Condit. Reinf. active-inactive response ratio2.82.95.61.9-1.51.91.91.72.1-1.2-1.71.20.5-2.4-1.6
Condit. Reinf. active responses2.73.86.52.5-2.52.02.01.82.5-1.3-2.31.40.4-2.2-0.9
Condit. Reinf. inactive responses0.20.31.20.8-1.10.20.20.30.6-0.0-0.70.10.2-0.10.6
Condit. Reinf. lever presses0.50.61.80.9-1.30.80.80.71.0-0.4-1.00.40.2-0.50.5
Condit. Reinf. lever reinforcers received2.63.76.12.4-2.42.12.11.92.5-1.2-2.21.20.6-2.3-0.8
Conditioned reinforcement - actives1.21.25.52.3-1.40.20.20.11.50.2-1.10.30.4-1.3-1.4
Conditioned reinforcement - inactives0.50.61.50.20.5-1.0-1.0-1.0-0.51.20.8-1.00.60.50.1
Conditioned locomotion0.80.94.12.0-1.60.20.20.21.30.5-1.0-0.20.8-0.8-0.1
Patch foraging indifference point 0 sec2.13.45.2-1.21.3-2.3-2.3-2.1-1.91.91.8-1.80.32.31.7
Patch foraging indifference point AUC0.10.20.60.8-0.4-0.5-0.5-0.40.30.6-0.1-0.30.1-0.0-0.2
Delay disc. indifference point, 0s delay4.65.09.81.1-1.32.12.12.01.9-3.0-2.13.1-2.5-2.0-2.7
Delay disc. indifference point, 16s delay0.90.91.90.4-0.61.31.31.40.9-1.2-0.81.00.1-1.2-0.4
Delay disc. indifference point, 2s delay3.43.88.00.4-1.42.72.72.71.5-2.8-1.92.3-0.7-1.6-0.2
Delay disc. indifference point, 24s delay0.50.51.20.1-0.11.11.11.10.5-0.8-0.40.50.4-1.0-0.4
Delay disc. indifference point, 4s delay1.81.93.50.4-1.01.91.91.81.1-1.9-1.31.6-0.5-1.2-0.1
Delay disc. indifference point, 8s delay1.01.12.20.6-0.81.41.41.51.0-1.0-0.90.70.8-1.20.1
Indifference point function ln k0.30.41.5-0.00.2-0.4-0.4-0.4-0.31.10.5-1.11.20.20.7
Indifference point function log k0.30.41.5-0.00.2-0.4-0.4-0.4-0.31.10.5-1.11.20.20.7
Patch foraging total patch changes 0 sec2.84.56.5-1.31.5-2.5-2.5-2.3-2.22.42.1-2.30.62.52.1
Patch foraging total patch changes 12 sec0.91.22.6-0.60.6-1.6-1.6-1.4-1.10.80.9-0.6-0.71.60.8
Patch foraging total patch changes 18 sec2.63.45.7-1.01.4-2.4-2.4-2.2-1.82.21.9-1.90.22.11.2
Patch foraging total patch changes 24 sec2.42.96.6-0.40.5-1.5-1.5-1.4-1.22.51.3-2.52.01.52.6
Patch foraging total patch changes 6 sec1.72.54.2-0.60.9-2.0-2.0-2.0-1.51.81.4-1.60.32.01.5
Patch foraging time to switch 0 sec1.72.69.3-1.40.61.01.00.9-0.2-2.8-0.52.5-3.0-0.2-1.6
Patch foraging water rate 0 sec2.23.610.61.0-0.2-2.0-2.0-2.0-0.43.31.0-2.82.41.21.8
Patch foraging water rate 12 sec0.91.36.10.7-0.4-0.3-0.3-0.40.11.80.3-1.82.50.11.6
Patch foraging water rate 18 sec1.01.47.00.9-1.01.01.00.90.90.7-0.6-0.92.7-1.01.3
Patch foraging water rate 24 sec0.71.03.91.5-1.0-0.5-0.5-0.40.61.4-0.2-1.32.0-0.20.8
Patch foraging water rate 6 sec0.91.34.40.7-0.7-0.5-0.5-0.60.01.60.2-1.62.00.62.1
Seeking ratio, delayed vs. immediate footshock2.12.45.5-2.12.3-1.3-1.3-1.2-2.01.32.1-1.50.31.30.6
Distance traveled before self-admin0.80.82.00.6-0.71.41.41.30.6-0.7-0.80.30.8-1.10.2
Distance traveled after self-admin0.30.30.60.6-0.50.60.60.70.5-0.1-0.5-0.10.8-0.70.1
Extensor digitorum longus weight1.35.016.64.1-3.90.30.30.33.0-1.0-3.01.9-1.3-1.1-1.4
Bone: elastic displacement0.10.10.30.4-0.2-0.5-0.5-0.50.10.30.0-0.2-0.10.2-0.2
Bone: elastic work0.40.62.31.5-1.1-0.8-0.8-0.80.70.3-0.60.2-0.40.2-0.5
Bone: endosteal estimation0.40.92.10.40.1-1.4-1.4-1.5-0.41.40.6-1.10.30.90.3
Bone: endosteal perimeter0.20.41.51.2-1.2-0.2-0.2-0.20.60.6-0.6-0.40.60.10.7
Epididymis fat weight0.20.51.30.5-1.10.60.60.70.6-0.8-0.90.7-0.1-0.10.7
Delta time in closed arm before/after self-admin0.60.61.31.0-0.70.80.81.20.70.1-0.7-0.10.9-1.0-0.1
Delta time in open arm before/after self-admin0.60.62.7-1.70.9-0.0-0.0-0.1-1.0-0.30.7-0.0-0.40.91.0
Diff in mean of infusions in LGA sessions0.20.20.70.5-0.70.30.30.30.40.0-0.4-0.00.4-0.10.8
Delay discount exponential model param3.03.16.1-0.91.4-2.4-2.4-2.5-1.62.11.7-1.7-0.21.90.4
Extinction: sum of active levers before priming0.30.30.9-0.3-0.30.90.91.00.2-0.7-0.40.4-0.1-0.30.5
Active lever presses in extinction session 60.00.00.10.2-0.4-0.0-0.0-0.10.2-0.2-0.30.2-0.30.10.1
Bone: final force1.01.64.02.0-1.50.30.30.41.6-0.9-1.41.3-0.8-1.2-1.9
Bone: final moment0.71.23.41.7-1.20.20.20.21.4-0.7-1.21.1-0.8-1.0-1.8
Food consumed during 24 hour testing period0.60.71.7-0.30.7-1.0-1.0-1.3-0.61.20.8-1.00.20.7-0.0
Glucose0.40.61.3-0.10.01.01.00.90.3-1.2-0.51.0-0.6-0.8-1.0
Heart weight1.42.011.71.4-0.60.90.90.71.01.3-0.2-1.63.4-1.50.6
Delay discount hyperbolic model param2.83.05.8-0.71.2-2.4-2.4-2.4-1.52.21.6-1.80.01.80.5
Intermittent access intake day 1-15 change0.80.81.90.20.4-1.3-1.3-1.4-0.41.20.7-0.90.20.6-0.3
Intermittent access intake escalation0.40.41.10.5-0.0-0.9-0.9-1.0-0.01.00.3-0.70.40.3-0.1
Intermittent access intake escalation 20.40.41.1-0.20.4-0.7-0.7-0.8-0.51.00.6-0.90.60.50.5
Intermitt. access day 1 inactive lever presses1.31.43.4-0.00.8-1.3-1.3-1.3-0.81.81.2-1.71.00.80.5
Intermitt. access day 15 inactive lever presses1.21.32.0-1.31.4-1.3-1.3-1.4-1.40.11.10.1-1.31.4-0.2
Intermitt. access escalation Index0.40.41.60.2-0.30.40.40.40.20.6-0.1-0.71.3-0.21.2
Intermittent access day 1 total infusions0.60.71.60.3-0.41.21.21.20.5-0.2-0.5-0.11.1-0.80.7
Intermittent access day 15 total infusions0.20.31.10.4-0.1-0.0-0.0-0.10.10.80.1-0.81.1-0.00.7
Intermittent access terminal intake (last 3 days)0.10.10.2-0.20.20.00.0-0.0-0.20.30.3-0.40.50.10.5
Intermittent access total infusions0.30.30.80.1-0.30.90.90.90.4-0.3-0.40.10.5-0.50.5
Intermittent access day 1 locomotion0.91.02.8-0.1-0.61.51.51.50.4-0.3-0.5-0.21.2-0.51.7
Intermittent access day 15 total locomotion1.21.34.71.0-1.11.01.01.00.80.8-0.6-1.02.2-0.81.6
Intermittent access total locomotion1.31.43.50.5-0.91.61.61.60.80.1-0.7-0.51.9-1.01.6
Intermittent access standard deviation1.51.63.3-0.91.2-1.8-1.8-1.8-1.30.81.2-0.5-0.91.5-0.1
Left kidney weight1.64.519.14.4-3.2-0.5-0.5-0.62.8-0.2-2.31.3-0.9-1.2-2.5
Right kidney weight1.33.713.03.6-2.6-0.6-0.6-0.72.3-0.5-2.01.6-1.6-0.9-2.7
Cocaine induced anxiety0.40.41.50.1-0.70.80.80.80.4-0.4-0.60.20.4-0.11.2
Post-drug Anxiety1.21.33.5-0.6-0.31.91.91.90.5-1.5-0.71.0-0.0-0.90.4
Baseline Anxiety0.91.02.5-1.10.71.11.11.1-0.1-1.6-0.11.2-1.0-0.6-0.9
Tail length2.37.022.14.7-3.80.70.70.83.6-1.3-3.22.2-1.1-2.3-3.1
Length with tail3.512.940.86.4-5.1-0.1-0.1-0.04.5-1.8-4.23.5-2.9-2.2-4.6
Length without tail2.45.210.53.2-3.1-0.2-0.2-0.32.3-2.0-2.62.9-3.2-0.6-2.6
Times rat made contact with spout0.50.61.41.2-0.90.50.50.41.0-0.4-0.90.5-0.2-1.1-1.2
Lifetime Intake0.20.20.4-0.30.00.70.70.60.1-0.7-0.20.5-0.2-0.30.0
Liver weight, left1.52.45.3-0.51.0-2.3-2.3-2.3-1.41.71.4-1.3-0.41.90.4
Liver weight, right0.40.72.71.6-1.3-0.9-0.9-0.90.70.5-0.70.1-0.50.4-0.2
Locomotor activity1.52.47.62.8-2.21.01.01.22.1-0.1-1.70.21.6-1.8-0.4
Locomotor testing distance0.30.41.00.9-0.4-0.8-0.8-0.50.11.00.1-0.80.90.20.4
Locomotor testing rearing0.81.22.0-0.70.7-1.3-1.3-1.1-1.21.21.1-1.10.31.41.4
Locomotion in novel chamber0.50.63.60.6-0.2-0.2-0.2-0.10.21.20.2-1.31.9-0.40.5
Locomotion in novel chamber post-restriction1.11.34.92.2-1.70.40.40.41.50.6-1.0-0.41.7-1.10.0
Fecal boli incidents, locomotor time 10.50.62.21.5-1.20.30.30.31.00.1-0.80.00.9-0.7-0.0
Change in fecal boli incidents, locomotor task0.70.61.9-1.11.1-0.6-0.6-0.5-0.9-0.10.70.2-1.40.7-0.6
Time >=10cm from walls, locomotor time 10.90.92.4-0.5-0.41.31.31.30.4-1.6-0.71.3-1.0-0.40.3
Bouts of movement, locomotor time 10.30.31.31.1-0.8-0.0-0.0-0.00.70.3-0.6-0.00.3-0.5-0.4
Total resting periods, locomotor time 10.30.31.31.1-0.90.10.10.20.90.1-0.70.10.3-0.6-0.4
Rest time, locomotor task time 10.20.20.50.7-0.70.10.10.10.6-0.3-0.60.5-0.6-0.2-0.4
Distance moved, locomotor task time 10.20.21.00.0-0.10.50.50.50.2-0.1-0.1-0.21.0-0.50.2
Vertical activity count, locomotor time 10.30.31.50.8-0.50.30.30.40.50.2-0.3-0.31.2-0.7-0.1
Time >=10cm from walls, locomotor time 21.81.94.20.9-1.41.11.11.11.2-1.9-1.52.0-2.0-0.6-0.8
Bouts of movement, locomotor time 20.30.31.31.1-1.1-0.1-0.1-0.10.70.3-0.6-0.00.3-0.10.3
Total resting periods, locomotor time 20.20.20.80.9-0.8-0.3-0.3-0.30.40.3-0.4-0.1-0.00.10.2
Rest time, locomotor task time 20.10.10.4-0.4-0.00.10.10.1-0.2-0.10.0-0.0-0.10.30.7
Distance moved, locomotor task time 20.10.20.70.10.5-0.4-0.4-0.4-0.10.40.4-0.30.2-0.2-0.8
Vertical activity count, locomotor time 20.50.51.31.1-0.2-0.7-0.7-0.70.41.00.1-0.70.8-0.4-1.0
Light reinforcement 11.01.83.80.5-0.91.91.91.91.1-1.6-1.21.30.3-1.6-0.4
Light reinforcement 20.20.30.8-0.60.9-0.4-0.4-0.3-0.60.50.7-0.60.40.3-0.0
Bone: marrow area0.51.02.30.40.2-1.4-1.4-1.5-0.41.50.7-1.20.40.90.4
Bone: maximum diameter0.30.51.41.2-1.1-0.3-0.3-0.40.8-0.2-0.80.7-0.90.1-0.4
Bone: maximum force0.40.83.01.7-1.3-0.1-0.1-0.11.2-0.2-1.00.7-0.5-0.5-0.9
Bone: maximum moment0.30.52.01.4-1.0-0.3-0.3-0.30.9-0.0-0.70.5-0.4-0.3-0.8
Mean time between licks in bursts0.60.92.0-1.41.1-0.3-0.3-0.3-1.20.71.1-1.00.80.81.4
Mean num. licks in bursts0.40.51.10.3-1.00.80.80.80.6-0.8-0.90.8-0.2-0.20.7
Cd content in liver2.22.46.6-1.11.3-0.7-0.7-0.7-1.22.21.6-2.52.60.61.8
Co content in liver1.72.03.6-0.61.2-1.8-1.8-1.8-1.21.91.5-1.70.71.30.5
Cu content in liver0.70.92.3-0.60.4-0.8-0.8-0.8-0.91.20.8-1.20.81.01.5
Fe content in liver1.01.24.71.8-2.20.50.50.51.3-0.0-1.40.20.7-0.41.0
K content in liver0.10.10.20.1-0.40.10.10.10.2-0.3-0.30.4-0.30.10.2
Mg content in liver0.10.10.30.5-0.4-0.0-0.0-0.00.4-0.2-0.30.4-0.4-0.2-0.5
Mn content in liver0.60.71.7-1.21.3-0.7-0.7-0.7-1.00.51.0-0.5-0.10.6-0.2
Na content in liver0.60.61.00.7-0.80.70.70.70.8-0.9-0.91.0-0.5-0.7-0.5
Rb content in liver0.50.62.9-1.30.60.10.10.1-0.90.30.6-0.60.50.81.7
Se content in liver2.32.85.61.4-2.41.61.61.61.8-2.0-2.22.2-1.2-1.0-0.1
Sr content in liver2.01.83.4-0.91.5-1.8-1.8-1.8-1.31.31.5-1.1-0.21.3-0.2
Zn content in liver1.01.13.10.50.1-1.7-1.7-1.7-0.31.00.5-0.4-0.71.1-0.3
Bone: minimum diameter0.00.00.1-0.00.1-0.2-0.2-0.2-0.10.30.2-0.30.30.10.1
Time in familiar zone, hab. session 11.71.62.7-1.51.5-1.4-1.4-1.4-1.70.71.4-0.7-1.01.60.4
Time in novel zone, hab. session 10.90.91.61.1-1.10.90.90.91.2-0.8-1.10.80.1-1.1-0.7
Total zone transitions, hab. session 10.50.72.0-0.0-0.21.31.31.30.3-0.3-0.3-0.21.4-0.90.7
Total locomotion distance, hab. session 10.30.51.20.0-0.61.11.11.10.4-0.7-0.60.40.2-0.50.6
Locomotion velocity, hab. session 10.50.71.9-0.1-0.41.41.41.40.4-0.7-0.50.30.7-0.70.9
Time in familiar zone, hab. session 20.30.31.9-0.50.3-0.2-0.2-0.2-0.3-0.50.10.6-1.40.5-0.3
Time in novel zone, hab. session 20.30.31.90.3-0.20.60.60.60.30.2-0.1-0.51.4-0.60.5
Total zone transitions, hab. session 20.20.30.80.7-0.20.40.40.40.50.0-0.3-0.00.6-0.9-0.8
Total locomotion distance, hab. session 20.10.10.50.2-0.10.50.50.50.20.0-0.1-0.20.7-0.60.1
Locomotion velocity, hab. session 20.10.10.60.20.00.40.40.50.20.1-0.0-0.30.8-0.6-0.0
Novel to familiar place preference ratio0.20.20.60.30.10.40.40.40.3-0.1-0.10.00.5-0.8-0.7
Novelty place preference0.20.20.50.10.30.40.40.40.1-0.10.0-0.10.6-0.7-0.5
Time in novel zone, NPP test0.10.10.50.20.10.40.40.40.2-0.1-0.10.00.5-0.7-0.6
Total zone transitions, NPP test0.20.30.60.7-0.60.70.70.70.7-0.3-0.60.20.5-0.8-0.1
Total locomotion distance, NPP test1.01.32.30.9-1.41.51.51.51.2-1.1-1.30.80.4-1.10.4
Locomotion velocity, NPP test1.01.42.21.1-1.51.51.51.51.3-0.7-1.30.51.0-1.20.5
Intraocular pressure0.30.41.31.1-1.1-0.4-0.4-0.40.50.5-0.5-0.30.40.30.7
Delta distance traveled before/after self-admin0.20.20.6-0.20.4-0.7-0.7-0.6-0.20.70.5-0.60.20.3-0.2
Delta ambulatory time before/after self-admin0.20.30.4-0.70.6-0.6-0.6-0.4-0.50.60.6-0.50.20.50.2
Parametrial fat weight0.30.61.9-0.50.8-0.9-0.9-0.8-0.5-0.10.50.4-1.40.5-1.3
Pavlov. Cond. lever latency0.40.51.00.9-0.3-1.0-1.0-1.00.10.4-0.1-0.1-0.60.2-1.0
Pavlov. Cond. magazine entry latency0.40.50.90.9-0.80.70.70.71.0-0.4-0.80.60.2-0.8-0.3
Pavlov. Cond. change in total contacts1.41.52.80.3-0.81.61.61.51.1-1.7-1.21.6-0.7-1.1-0.5
Pavlov. Cond. index score0.40.50.90.3-0.71.01.00.90.8-0.8-0.70.80.0-0.60.2
Pavlov. Cond. latency score0.50.71.40.2-0.71.21.21.20.8-0.9-0.80.80.1-0.70.2
Pavlov. Cond. lever contacts0.30.40.9-0.70.10.90.90.90.1-0.6-0.10.30.3-0.20.8
Pavlov. Cond. magazine entry number0.70.81.9-1.21.4-0.9-0.9-0.9-1.30.41.1-0.5-0.50.9-0.1
Pavlov. Cond. intertrial magazine entries0.60.71.2-1.01.0-0.4-0.4-0.4-0.90.81.0-1.11.00.61.0
Pavlov. Cond. lever-magazine prob. diff.0.30.40.60.2-0.60.80.80.70.6-0.7-0.60.8-0.2-0.40.1
Pavlov. Cond. response bias0.40.50.90.7-1.00.80.80.80.9-0.6-0.80.60.2-0.60.2
Pavlov. Cond. lever latency1.72.34.1-1.31.7-2.0-2.0-1.9-1.81.11.7-0.9-0.81.7-0.0
Pavlov. Cond. magazine entry latency1.92.24.70.5-1.12.22.22.11.3-1.8-1.41.30.1-1.6-0.1
Pavlov. Cond. change in total contacts0.91.32.31.0-1.11.51.51.41.2-0.5-1.00.21.4-1.40.2
Pavlov. Cond. index score1.72.14.40.9-1.42.12.12.01.5-1.1-1.40.71.1-1.70.4
Pavlov. Cond. latency score1.61.94.10.8-1.32.02.01.91.4-1.2-1.40.80.8-1.50.3
Pavlov. Cond. lever contacts1.41.93.41.0-1.61.81.81.71.5-1.1-1.50.90.5-1.30.4
Pavlov. Cond. magazine entry number1.21.53.8-0.40.8-1.9-1.9-1.8-1.01.11.0-0.6-0.91.5-0.3
Pavlov. Cond. intertrial magazine entries0.10.20.40.6-0.2-0.4-0.4-0.40.20.60.0-0.50.5-0.1-0.1
Pavlov. Cond. lever-magazine prob. diff.1.82.34.80.9-1.42.22.22.11.5-1.1-1.40.71.2-1.80.3
Pavlov. Cond. response bias2.02.75.31.1-1.72.32.32.21.7-1.3-1.70.91.0-1.60.7
Time in closed arm before self-admin0.50.61.90.80.0-1.1-1.1-1.4-0.11.00.3-0.70.40.4-0.3
Time in closed arm after self-admin0.90.94.21.4-0.6-0.1-0.10.10.51.3-0.1-1.32.0-0.60.4
Time in open arm before self-admin0.40.41.00.7-0.60.80.80.80.8-0.3-0.70.30.3-1.0-0.5
Time in open arm after self-admin0.30.31.8-0.60.20.00.00.0-0.2-0.9-0.10.8-1.30.3-0.3
Bone: periosteal estimation0.30.52.41.6-1.3-0.2-0.2-0.30.90.0-0.90.4-0.3-0.3-0.6
Bone: periosteal perimeter0.81.34.01.7-2.00.90.90.91.5-0.6-1.50.70.4-0.80.4
Bone: post-yield work0.10.20.90.2-0.5-0.4-0.4-0.4-0.00.3-0.1-0.1-0.10.60.9
Progressive ratio test 1 active lever presses0.10.10.60.7-0.30.10.10.10.40.1-0.20.00.2-0.5-0.6
Progressive ratio test 1 breakpoint0.20.20.90.8-0.30.20.20.10.5-0.1-0.30.20.0-0.7-0.9
Progressive ratio test 1 inactive lever presses0.50.61.81.0-0.1-0.5-0.5-0.50.21.30.3-1.11.3-0.20.1
Progressive ratio test 2 active lever presses0.80.92.71.7-1.10.70.70.61.20.4-0.8-0.31.2-1.2-0.3
Progressive ratio test 2 breakpoint0.91.02.41.5-1.00.90.90.91.20.3-0.8-0.31.4-1.4-0.3
Progressive ratio test 2 inactive lever presses1.41.65.21.3-0.3-1.2-1.2-1.20.02.30.5-1.91.80.40.9
Incentive Sensitization - Responses0.40.41.70.6-0.50.60.60.50.50.5-0.3-0.61.3-0.60.6
Incentive Sensitization - Breakpoint0.50.52.10.7-0.50.60.60.60.50.6-0.3-0.71.4-0.60.8
Sum of active levers in priming session hrs 5-60.60.62.2-0.5-0.20.60.60.50.1-1.5-0.51.3-1.40.1-0.2
Progressive ratio0.50.61.3-1.11.1-0.5-0.5-0.4-1.00.61.0-0.70.30.60.5
Food seeking constrained by brief footshock3.23.95.4-2.22.1-2.0-2.0-1.9-2.31.92.2-1.90.32.31.7
Seeking ratio, punishment vs. effort0.20.20.50.2-0.1-0.7-0.7-0.7-0.10.40.1-0.2-0.30.60.1
Retroperitoneal fat weight0.92.89.6-0.8-0.71.81.81.60.5-3.1-1.32.7-2.2-0.3-0.1
Reaction time number correct0.71.13.20.30.3-1.1-1.1-1.2-0.41.80.8-1.51.20.70.7
Reaction time mean minus median5.16.810.12.2-3.13.23.23.22.9-2.5-3.12.30.3-2.6-0.4
Reaction time mean minus median AUC1.72.24.21.0-1.62.02.02.01.5-0.9-1.50.61.3-1.50.7
Reaction time num false alarms1.41.93.51.2-1.41.81.81.91.5-0.7-1.30.41.4-1.70.4
Reaction time num false alarms AUC1.01.42.31.1-1.51.51.51.51.3-0.4-1.20.21.3-1.20.8
Reaction time trials correct on left0.71.13.20.30.3-1.1-1.1-1.2-0.41.80.8-1.51.20.70.7
Reaction time trials on left0.71.02.90.30.2-1.0-1.0-1.1-0.31.70.7-1.51.20.60.7
Reaction time mean1.82.65.9-0.3-0.52.42.42.41.0-2.2-1.21.7-0.3-1.7-0.6
Reaction time mean AUC1.72.25.4-0.3-0.52.32.32.30.9-2.0-1.11.5-0.1-1.5-0.3
Median of all reaction times1.11.53.5-1.10.41.91.91.80.2-1.8-0.41.2-0.4-1.1-0.5
Reaction time omissions1.01.43.20.3-0.91.81.81.71.0-1.1-1.00.80.7-1.20.3
Reaction time false alarm rate1.52.14.21.0-1.61.91.92.01.5-1.3-1.51.00.6-1.50.4
Reaction time premature initiation rate0.70.91.50.7-1.01.21.21.21.0-0.8-1.00.70.3-1.2-0.3
Reaction time premature initiations0.30.40.60.7-0.70.60.60.60.70.0-0.6-0.00.7-0.70.0
Std. dev. reaction times2.73.97.11.0-1.92.72.72.61.9-2.2-2.11.90.1-2.0-0.2
Reaction time trials completed0.71.02.90.30.2-1.0-1.0-1.1-0.31.70.7-1.51.20.60.7
Reaction time trials AUC0.81.13.20.20.3-1.0-1.0-1.1-0.41.80.8-1.61.40.70.9
Run reversals in cocaine runway, females0.30.30.6-0.80.6-0.3-0.3-0.4-0.60.40.6-0.50.10.60.7
Run reversals in cocaine runway, males1.11.13.8-0.10.6-0.7-0.7-0.7-0.51.70.9-1.72.00.30.9
Latency to leave start box in cocaine runway0.50.51.60.2-0.10.70.70.80.4-1.0-0.50.9-0.7-0.8-1.3
Latency to leave start box in cocaine runway, F0.50.52.8-0.10.4-0.2-0.2-0.1-0.0-0.6-0.00.8-1.4-0.2-1.7
Latency to leave start box in cocaine runway, M0.90.93.90.4-0.61.11.11.00.50.1-0.4-0.52.0-0.81.2
Std. dev. time between licks in bursts0.30.41.40.8-0.80.40.40.40.60.2-0.4-0.31.2-0.40.8
Total sessions with >9 infusions0.20.20.30.4-0.40.50.50.50.5-0.5-0.50.5-0.2-0.5-0.3
Short access day 1 total inactive lever presses0.30.30.5-0.30.6-0.7-0.7-0.7-0.50.70.7-0.60.30.40.1
Short access day 10 total inactive lever presses1.21.33.40.10.5-1.8-1.8-1.9-0.71.20.8-0.8-0.41.3-0.0
Short access day 1 total infusions1.11.13.2-1.81.5-0.8-0.8-0.8-1.5-0.21.10.0-1.11.30.2
Short access day 10 total infusions0.10.10.5-0.70.40.20.20.2-0.5-0.20.30.0-0.10.30.7
Short access total infusions0.50.62.0-0.90.70.20.20.2-0.4-1.20.11.1-1.40.1-0.9
Short access day 1 locomotion1.01.02.70.1-0.41.71.71.70.7-0.9-0.80.50.6-1.3-0.1
Short access day 10 total locomotion0.50.51.9-0.80.6-0.4-0.4-0.4-0.80.60.7-0.80.40.91.4
Short access total locomotion0.30.30.7-0.50.00.90.90.9-0.0-0.9-0.30.5-0.2-0.20.3
One hour access (0.3 mA shock)1.01.24.70.50.3-0.4-0.4-0.4-0.21.90.7-1.92.2-0.01.0
Compulsive drug intake1.01.02.3-1.41.5-0.2-0.2-0.2-1.30.81.3-1.20.80.60.9
One hour access (shock baseline)0.70.92.71.7-1.40.50.50.41.20.6-0.9-0.41.3-0.90.3
Social response proportion5.15.510.23.2-2.61.81.81.83.0-1.8-2.62.1-0.3-2.8-2.7
Social responses1.11.44.82.2-1.90.70.70.71.60.0-1.40.21.1-1.2-0.1
Social time0.60.82.1-0.30.21.41.41.40.1-0.6-0.10.01.2-1.10.2
Soleus weight0.20.62.21.5-1.5-0.6-0.6-0.60.70.5-0.7-0.10.00.40.6
Bone: stiffness0.71.12.71.7-1.50.90.91.01.4-0.5-1.30.60.5-1.2-0.4
Tibialis anterior weight2.27.520.24.5-4.40.80.80.83.6-1.9-3.62.9-2.0-1.7-2.2
Time to tail flick, vehicle, before self-admin1.81.83.50.4-0.51.81.81.70.9-1.9-1.11.5-0.5-1.6-1.3
Time to tail flick, vehicle, after self-admin0.50.51.10.4-0.51.11.11.00.6-0.6-0.60.30.6-1.0-0.1
Time to tail flick, test, before self-admin0.20.20.80.7-0.2-0.4-0.4-0.30.30.1-0.20.2-0.5-0.1-0.9
Time to tail flick, test, after self-admin0.50.51.50.1-0.30.40.40.50.3-1.2-0.61.2-1.2-0.3-0.9
Delta time to tail flick, vehicle, before/after SA0.60.61.4-0.60.4-0.5-0.5-0.5-0.60.90.7-1.00.80.71.2
Delta time to tail flick, test, before/after SA0.20.20.4-0.60.2-0.0-0.0-0.0-0.5-0.40.20.3-0.50.60.6
Tibia length1.13.214.22.0-1.1-0.6-0.6-0.61.3-1.2-1.22.1-2.7-0.8-3.8
Ambulatory time before self-admin1.61.63.20.9-1.41.81.81.71.1-1.0-1.30.61.0-1.30.6
Ambulatory time after self-admin0.40.40.90.5-0.80.80.80.90.6-0.4-0.70.20.5-0.60.4
Bone: tissue strength2.12.03.1-1.21.5-1.8-1.8-1.7-1.61.31.6-1.1-0.31.60.5
Total heroin consumption1.11.33.4-0.3-0.61.81.81.80.6-0.8-0.70.21.1-0.81.5
Bone: trabecular number0.60.92.11.3-1.1-1.2-1.2-1.20.40.3-0.50.4-1.50.8-0.3
Bone: trabecular spacing0.60.82.7-1.71.30.20.20.2-1.10.21.0-0.70.90.41.0
Bone: trabecular thickness0.70.92.71.5-1.7-0.7-0.7-0.70.8-0.1-1.00.7-1.30.60.1
Bone: trabecular tissue density5.37.511.52.2-2.63.43.43.32.9-2.9-3.02.6-0.0-3.2-1.5
Water consumed over 24 hours0.40.51.01.0-0.3-0.8-0.8-1.00.40.9-0.0-0.50.0-0.1-1.0
Number of responses in last shaping day0.10.10.30.00.3-0.3-0.3-0.4-0.20.50.3-0.50.30.20.2