Hub : Genes

Pnpla6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Pnpla6 0.07 0.04 7.4e-05 0.04 0.04 0.02 0.03 2.6e-05 5.9e-05 1.3e-03 2.1e-04
2 pVTA gene expression Pnpla6 0.2 0.08 2.9e-13 0.14 0.18 0.19 0.19 3.3e-11 1.1e-14 5.5e-15 6.3e-15
3 BLA gene expression Pnpla6 0.19 0.09 5.0e-07 0.1 0.13 0.09 0.11 6.9e-06 3.5e-07 1.1e-05 2.2e-06
4 Brain intron excision ratio chr12_6372456_6373559 0.03 0.02 2.9e-03 0.03 0.03 0.02 0.02 1.5e-03 1.5e-03 3.7e-03 3.0e-03
5 Adipose gene expression Pnpla6 0.04 0.02 1.3e-03 0.02 0.01 0.01 0.01 2.7e-03 3.3e-02 1.8e-02 2.0e-02
6 pVTA mRNA stability Pnpla6 0.07 0.04 1.8e-06 0.09 0.08 0.06 0.08 1.9e-07 4.6e-07 6.3e-06 3.0e-07
7 OFC mRNA stability Pnpla6 0.21 0.11 7.1e-04 0.02 0.08 0.06 0.05 1.0e-01 6.4e-03 1.5e-02 2.3e-02
8 LHb alternative TSS NM_001427127.1 0.17 0.11 9.7e-03 0.06 0.09 0.05 0.07 1.9e-02 3.6e-03 2.6e-02 1.1e-02
9 LHb alternative TSS NM_001427127.1 0.17 0.11 8.1e-03 0.06 0.1 0.06 0.07 1.6e-02 2.9e-03 2.0e-02 8.4e-03
10 Brain gene expression Pnpla6 0.15 0.07 2.1e-15 0.12 0.17 0.17 0.17 1.1e-11 1.2e-15 7.4e-16 4.2e-16
11 NAcc gene expression Pnpla6 0.09 0.04 2.7e-13 0.07 0.1 0.09 0.08 1.7e-11 3.5e-14 2.0e-13 9.7e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.91.65.8-0.9-0.4-0.82.42.0-1.50.30.90.80.31.6
Area under the delay curve2.83.25.8-0.4-1.3-1.1-2.4-2.32.11.5-2.0-2.0-1.6-2.0
BMI with tail0.30.92.5-1.0-1.6-1.50.80.7-0.61.0-0.7-0.7-0.60.1
BMI without tail1.13.59.5-2.6-3.1-2.90.1-0.30.41.7-1.4-1.5-2.0-1.3
Body weight2.812.338.7-5.5-6.2-5.51.30.4-0.02.9-2.1-2.2-3.6-1.9
Weight adjusted by age0.40.61.9-0.1-0.10.11.21.0-1.4-0.50.70.60.60.8
Bone surface0.61.22.7-1.6-1.5-1.61.51.1-0.50.9-0.1-0.2-0.80.5
Bone volume0.50.93.0-0.6-0.6-1.01.71.4-1.00.70.20.20.11.2
Breakpoint value in progressive ratio session1.51.82.5-1.1-1.1-1.4-1.2-1.31.51.6-1.4-1.4-1.4-1.2
Number of licking bursts0.81.44.5-0.20.31.01.21.2-0.9-2.11.61.60.60.4
Context. condit. distance diff. score3.03.67.6-2.7-2.3-2.8-0.4-1.01.12.4-1.6-1.6-2.0-1.2
Locomotion velocity, session 10.50.62.1-0.3-0.1-0.2-1.0-0.91.40.5-0.7-0.6-0.9-0.7
Locomotion distance, session 10.20.20.80.30.70.5-0.7-0.60.9-0.0-0.1-0.1-0.2-0.2
Locomotion velocity, session 20.30.40.9-0.5-0.2-0.0-0.9-0.81.0-0.1-0.3-0.3-0.7-0.9
Locomotion distance, session 20.20.20.80.30.90.7-0.5-0.40.7-0.40.40.40.0-0.1
Locomotion velocity, session 30.40.40.9-0.7-0.7-0.9-0.3-0.50.51.0-0.7-0.7-0.7-0.4
Locomotion distance, session 30.50.50.70.60.80.50.80.7-0.8-0.40.80.80.80.8
Stereotopy head waving bouts, day 30.50.61.9-0.7-0.7-0.61.31.0-1.4-0.10.50.50.30.5
Stereotopy head waving duration, day 30.20.20.50.30.30.40.40.5-0.7-0.40.40.40.60.5
Locomotion velocity, session 72.32.54.5-1.0-1.0-0.8-2.1-2.02.01.1-1.7-1.7-1.6-1.9
Locomotion distance, session 71.11.42.3-1.0-0.8-0.9-1.4-1.51.31.1-1.1-1.1-1.1-1.4
Stereotopy head waving bouts, day 70.00.00.1-0.10.20.0-0.4-0.40.30.2-0.1-0.1-0.1-0.2
Stereotopy head waving duration, day 70.10.10.30.30.40.4-0.5-0.40.4-0.1-0.1-0.10.0-0.2
Locomotion velocity, session 80.70.81.3-1.0-1.0-0.7-0.9-1.00.90.5-0.9-0.8-1.0-1.2
Locomotion distance, session 81.21.83.5-1.9-1.5-1.7-0.6-0.91.31.3-1.1-1.1-1.7-1.1
Degree of sensitization distance1.01.02.5-0.4-0.4-0.2-1.6-1.41.30.4-0.9-0.9-0.9-1.3
Degree of sensitization stereotypy0.20.20.5-0.00.1-0.0-0.7-0.60.60.4-0.4-0.4-0.3-0.4
Conditioned locomotion0.70.82.10.90.70.41.00.8-1.4-0.20.70.71.21.2
Cocaine response after cond. corrected0.30.41.21.10.30.70.30.8-0.7-0.70.10.10.70.5
Cocaine response after cond. not corrected0.10.10.40.5-0.2-0.1-0.30.1-0.00.3-0.7-0.70.10.0
Cocaine response before conditioning1.92.35.5-1.6-1.1-1.9-1.1-1.41.42.3-1.5-1.5-1.4-1.0
Saline control response0.70.94.6-2.1-1.1-1.11.20.4-0.60.10.70.6-0.6-0.0
Bone: connectivity density1.01.54.1-2.0-1.5-1.71.91.3-0.70.80.30.3-0.80.7
Bone: cortical apparent density0.30.51.30.2-0.3-0.1-1.2-1.00.60.3-0.8-0.8-0.4-0.9
Bone: cortical area2.33.55.9-2.1-2.4-2.4-1.1-1.31.32.0-1.8-1.9-2.0-1.7
Bone: cortical porosity0.20.20.30.10.30.30.60.5-0.5-0.40.60.50.40.4
Bone: cortical porosity0.00.00.10.00.30.10.1-0.00.10.10.10.10.10.2
Bone: cortical thickness1.32.14.4-1.7-2.1-2.0-0.7-1.00.71.4-1.4-1.4-1.5-1.4
Bone: cortical thickness0.91.12.6-1.6-1.4-1.5-0.3-0.60.61.0-0.7-0.7-1.1-0.9
Bone: cortical tissue density0.20.31.10.3-0.20.1-1.0-0.80.50.1-0.6-0.6-0.2-0.7
Condit. Reinf. active minus inactive responses0.30.31.00.30.0-0.1-1.0-0.80.50.6-0.8-0.8-0.2-0.5
Condit. Reinf. active-inactive response ratio0.60.61.3-0.0-0.4-0.5-1.1-1.00.60.9-1.1-1.1-0.4-0.7
Condit. Reinf. active responses0.30.40.7-0.20.0-0.3-0.8-0.80.70.8-0.7-0.7-0.4-0.5
Condit. Reinf. inactive responses0.10.10.4-0.30.3-0.1-0.5-0.60.60.5-0.1-0.1-0.3-0.2
Incentive salience index mean0.20.30.70.20.2-0.2-0.7-0.70.40.9-0.6-0.6-0.1-0.2
Condit. Reinf. lever presses0.10.20.90.00.2-0.3-0.4-0.50.40.9-0.4-0.4-0.10.0
Condit. Reinf. active minus inactive responses2.93.75.9-2.4-2.1-2.0-1.5-1.62.11.4-1.6-1.6-2.4-2.2
Condit. Reinf. active-inactive response ratio2.42.85.0-1.9-1.6-1.3-1.6-1.62.20.9-1.3-1.3-2.1-2.0
Condit. Reinf. active responses3.24.56.6-2.6-2.3-2.5-1.5-1.82.02.1-1.9-1.9-2.4-2.1
Condit. Reinf. inactive responses0.40.61.8-0.9-0.8-1.3-0.0-0.40.11.3-0.6-0.7-0.6-0.3
Condit. Reinf. lever presses0.81.22.4-1.0-0.8-1.3-0.7-0.81.11.5-1.1-1.1-1.1-0.8
Condit. Reinf. lever reinforcers received3.04.25.8-2.4-2.1-2.3-1.6-1.82.12.0-1.8-1.8-2.3-2.1
Conditioned reinforcement - actives0.61.04.1-2.0-1.5-1.50.4-0.0-0.00.5-0.3-0.3-1.1-0.7
Conditioned reinforcement - inactives0.50.71.30.20.40.51.21.0-1.0-1.01.11.10.60.7
Conditioned locomotion1.11.44.0-2.0-1.5-1.90.1-0.40.41.5-0.7-0.7-1.2-0.7
Patch foraging indifference point 0 sec1.93.55.91.11.61.42.32.2-2.0-1.32.02.01.82.4
Patch foraging indifference point AUC0.20.30.9-0.8-0.5-0.40.90.5-0.8-0.30.50.50.00.2
Delay disc. indifference point, 0s delay3.74.15.9-1.0-2.2-1.5-2.3-2.12.01.3-2.4-2.4-2.0-2.4
Delay disc. indifference point, 16s delay0.70.81.5-0.4-0.6-0.5-1.2-1.21.10.7-0.9-0.9-0.8-1.1
Delay disc. indifference point, 2s delay4.24.68.6-0.1-1.2-1.2-2.9-2.82.42.2-2.6-2.6-1.6-2.1
Delay disc. indifference point, 24s delay0.30.41.30.20.00.1-1.1-0.90.80.1-0.6-0.5-0.3-0.9
Delay disc. indifference point, 4s delay2.42.54.2-0.2-1.0-1.0-2.0-1.91.81.7-1.9-1.9-1.3-1.5
Delay disc. indifference point, 8s delay0.91.11.9-0.3-0.7-0.7-1.3-1.41.31.0-1.0-1.0-1.0-1.1
Indifference point function ln k0.00.10.2-0.20.30.10.30.30.2-0.20.50.5-0.00.3
Indifference point function log k0.00.10.2-0.20.30.10.30.30.2-0.20.50.5-0.00.3
Patch foraging total patch changes 0 sec2.54.87.71.31.91.62.72.5-2.3-1.52.32.32.12.8
Patch foraging total patch changes 12 sec1.31.73.50.70.80.61.81.6-1.9-0.71.11.11.41.7
Patch foraging total patch changes 18 sec2.53.86.10.91.51.42.52.3-2.2-1.62.12.11.82.3
Patch foraging total patch changes 24 sec1.32.24.10.31.40.72.01.7-1.5-0.61.71.71.42.0
Patch foraging total patch changes 6 sec1.92.85.40.61.20.92.32.1-1.9-1.01.81.81.52.2
Patch foraging time to switch 0 sec0.61.23.51.70.00.6-1.9-1.00.90.1-1.5-1.40.1-0.9
Patch foraging water rate 0 sec1.22.57.5-1.40.2-0.32.72.0-1.8-0.52.02.00.61.7
Patch foraging water rate 12 sec0.10.30.8-0.90.1-0.40.80.4-0.10.30.60.6-0.10.4
Patch foraging water rate 18 sec0.40.71.3-1.1-0.3-1.0-0.6-0.91.01.1-0.4-0.4-0.8-0.7
Patch foraging water rate 24 sec0.50.73.2-1.8-0.8-1.01.20.6-0.20.40.60.6-0.60.3
Patch foraging water rate 6 sec0.30.41.1-0.90.1-0.71.00.7-0.10.70.50.5-0.10.8
Seeking ratio, delayed vs. immediate footshock3.03.65.82.22.32.41.11.6-1.4-2.21.81.82.11.7
Distance traveled before self-admin0.40.51.20.20.1-0.1-1.1-1.01.00.7-0.7-0.7-0.4-0.6
Distance traveled after self-admin0.10.20.4-0.5-0.1-0.4-0.4-0.60.40.6-0.3-0.3-0.3-0.4
Extensor digitorum longus weight1.76.718.5-4.0-4.0-4.30.6-0.50.22.9-1.6-1.7-2.4-1.4
Bone: elastic displacement0.10.10.2-0.5-0.2-0.20.50.3-0.2-0.00.20.2-0.10.1
Bone: elastic work0.60.82.8-1.7-1.3-1.41.10.7-0.30.50.10.1-0.70.0
Bone: endosteal estimation0.40.82.6-0.7-0.0-0.11.61.3-0.9-0.51.11.10.20.9
Bone: endosteal perimeter0.30.62.2-1.5-0.9-1.30.40.00.31.1-0.3-0.3-0.8-0.1
Epididymis fat weight0.10.20.9-0.2-0.2-0.6-0.1-0.20.20.9-0.5-0.5-0.30.0
Delta time in closed arm before/after self-admin1.21.11.6-1.1-1.3-1.0-1.0-1.11.10.8-0.9-0.9-1.2-1.3
Delta time in open arm before/after self-admin0.80.83.21.81.61.1-0.30.00.0-0.10.00.00.90.7
Diff in mean of infusions in LGA sessions0.10.10.3-0.5-0.4-0.60.0-0.10.10.5-0.3-0.3-0.3-0.1
Delay discount exponential model param3.13.46.40.41.11.12.52.4-2.2-1.72.12.11.62.0
Extinction: sum of active levers before priming0.50.51.10.1-0.2-0.5-0.8-0.71.10.9-0.9-0.9-0.6-0.5
Active lever presses in extinction session 60.00.00.1-0.10.1-0.20.40.3-0.20.20.10.10.00.3
Bone: final force1.01.54.4-2.0-2.1-1.6-0.1-0.40.70.6-0.7-0.7-1.6-1.2
Bone: final moment0.71.13.3-1.7-1.8-1.40.0-0.30.50.4-0.5-0.5-1.3-1.0
Food consumed during 24 hour testing period0.81.01.90.30.80.71.21.4-1.2-1.11.11.11.00.9
Glucose0.50.72.40.40.20.3-1.5-1.11.20.3-0.9-0.9-0.4-0.9
Heart weight0.50.82.5-1.6-0.7-1.1-0.5-0.71.00.8-0.4-0.4-1.1-1.0
Delay discount hyperbolic model param3.03.46.10.41.21.12.52.4-2.2-1.72.12.11.62.0
Intermittent access intake day 1-15 change0.51.02.3-0.20.10.41.51.3-1.4-1.21.21.20.50.8
Intermittent access intake escalation0.51.02.1-0.20.10.41.51.3-1.4-1.31.21.20.60.7
Intermittent access intake escalation 20.70.81.40.40.60.80.90.9-1.0-1.21.01.00.70.7
Intermitt. access day 1 inactive lever presses0.31.01.70.40.60.81.21.1-1.2-1.31.31.30.80.9
Intermitt. access day 15 inactive lever presses0.50.92.31.50.81.10.70.9-1.1-0.90.60.61.11.1
Intermitt. access escalation Index0.20.20.6-0.50.0-0.4-0.5-0.60.70.8-0.4-0.4-0.4-0.3
Intermittent access day 1 total infusions0.40.61.5-0.40.1-0.5-1.1-1.21.00.9-0.7-0.7-0.6-0.8
Intermittent access day 15 total infusions0.00.10.3-0.6-0.0-0.3-0.1-0.40.10.10.00.0-0.3-0.3
Intermittent access terminal intake (last 3 days)0.00.10.1-0.30.0-0.2-0.3-0.40.20.1-0.1-0.1-0.3-0.4
Intermittent access total infusions0.60.81.3-0.5-0.3-0.7-1.1-1.20.90.9-0.9-0.9-0.8-1.0
Intermittent access day 1 locomotion0.91.12.2-0.20.1-0.7-1.3-1.41.31.5-1.1-1.1-0.7-0.8
Intermittent access day 15 total locomotion0.20.41.0-1.0-0.2-0.9-0.0-0.70.51.0-0.1-0.1-0.7-0.2
Intermittent access total locomotion0.70.81.9-0.5-0.1-0.9-0.9-1.21.11.4-0.9-0.9-0.8-0.7
Intermittent access standard deviation0.91.83.01.20.91.21.41.5-1.7-1.61.31.31.41.2
Left kidney weight1.36.118.2-4.3-4.2-3.82.61.6-1.51.3-0.2-0.3-1.8-0.3
Right kidney weight1.15.016.2-3.8-4.0-3.42.21.4-1.21.1-0.3-0.4-1.8-0.4
Cocaine induced anxiety0.91.32.1-0.6-0.7-1.0-1.2-1.11.41.4-1.3-1.3-1.1-1.0
Post-drug Anxiety3.43.68.00.5-0.6-0.5-2.8-2.22.61.5-2.4-2.4-1.4-1.8
Baseline Anxiety0.80.92.81.40.40.9-1.7-0.91.1-0.5-0.9-0.9-0.1-0.8
Tail length2.49.327.1-5.0-5.2-4.60.5-0.60.72.2-1.7-1.7-3.4-2.3
Length with tail3.716.251.0-6.9-7.1-6.21.40.00.12.7-1.9-2.0-4.3-2.6
Length without tail1.44.513.8-3.5-3.7-3.02.51.8-1.50.7-0.0-0.1-1.5-0.1
Times rat made contact with spout0.60.72.0-1.4-1.1-1.0-0.3-0.40.80.6-0.6-0.6-1.1-0.9
Lifetime Intake0.40.51.0-0.1-0.0-0.4-1.0-1.00.70.7-0.8-0.8-0.5-0.7
Liver weight, left2.54.210.2-0.40.20.43.22.8-2.8-1.82.32.31.41.9
Liver weight, right0.30.61.6-1.0-1.0-1.01.30.9-0.70.30.20.2-0.30.4
Locomotor activity1.52.36.5-2.5-2.1-2.2-0.3-1.10.71.4-0.8-0.8-1.7-1.3
Locomotor testing distance0.20.41.1-1.0-0.4-0.41.00.5-0.6-0.10.70.6-0.10.4
Locomotor testing rearing0.61.12.30.70.90.81.41.2-1.0-0.61.11.11.01.5
Locomotion in novel chamber0.30.31.7-1.3-0.4-0.60.70.3-0.20.00.60.6-0.2-0.1
Locomotion in novel chamber post-restriction0.81.34.9-2.2-1.5-1.70.0-0.70.51.0-0.3-0.4-1.2-0.9
Fecal boli incidents, locomotor time 10.81.23.5-1.9-1.6-1.7-0.0-0.40.41.1-0.6-0.6-1.1-0.9
Change in fecal boli incidents, locomotor task0.20.20.70.80.40.8-0.00.3-0.2-0.90.20.20.30.2
Time >=10cm from walls, locomotor time 11.21.32.60.4-0.3-0.5-1.6-1.61.11.3-1.5-1.5-0.6-0.9
Bouts of movement, locomotor time 10.30.41.4-1.2-1.0-0.90.40.10.00.4-0.1-0.1-0.6-0.3
Total resting periods, locomotor time 10.40.51.6-1.3-1.1-1.00.20.00.10.5-0.2-0.2-0.7-0.5
Rest time, locomotor task time 10.40.51.7-1.3-1.1-1.10.20.20.10.7-0.5-0.5-0.7-0.4
Distance moved, locomotor task time 10.20.31.20.0-0.00.0-0.8-1.10.70.2-0.3-0.3-0.4-0.6
Vertical activity count, locomotor time 10.10.31.1-0.5-0.6-0.5-0.4-1.00.60.3-0.2-0.2-0.7-0.6
Time >=10cm from walls, locomotor time 21.42.13.4-0.9-1.5-1.5-1.2-1.31.11.7-1.8-1.9-1.3-1.2
Bouts of movement, locomotor time 20.30.41.2-1.1-0.9-1.10.40.0-0.40.9-0.3-0.3-0.4-0.1
Total resting periods, locomotor time 20.20.30.7-0.8-0.7-0.90.60.3-0.60.6-0.1-0.1-0.10.1
Rest time, locomotor task time 20.00.00.10.20.20.0-0.10.20.20.4-0.2-0.20.00.2
Distance moved, locomotor task time 20.20.20.9-0.10.10.40.30.1-0.6-1.00.60.60.4-0.1
Vertical activity count, locomotor time 20.30.41.0-1.0-0.7-0.40.90.5-0.8-0.70.70.7-0.2-0.2
Light reinforcement 10.92.34.5-0.3-0.6-0.7-2.1-1.92.11.4-1.7-1.7-1.3-1.6
Light reinforcement 20.20.30.70.80.70.80.20.3-0.2-0.80.60.60.60.4
Bone: marrow area0.40.92.7-0.60.1-0.11.71.4-1.0-0.61.21.20.30.9
Bone: maximum diameter0.40.72.0-1.3-1.3-1.40.30.1-0.00.9-0.5-0.6-0.7-0.3
Bone: maximum force0.61.03.0-1.7-1.7-1.60.3-0.20.30.7-0.4-0.4-1.2-0.7
Bone: maximum moment0.40.72.1-1.4-1.4-1.30.40.00.20.5-0.2-0.2-0.9-0.5
Mean time between licks in bursts0.30.82.21.21.51.20.10.2-0.5-0.60.70.71.10.8
Mean num. licks in bursts0.50.82.7-0.3-0.6-1.0-0.7-0.80.81.6-1.2-1.2-0.7-0.4
Cd content in liver0.50.61.1-0.8-0.4-0.7-0.8-1.10.90.7-0.4-0.4-0.8-1.0
Co content in liver3.54.06.00.91.31.52.32.2-2.5-2.12.42.41.91.9
Cu content in liver0.10.10.30.20.50.30.40.30.1-0.10.40.40.10.5
Fe content in liver1.41.75.1-1.3-1.0-1.8-0.5-0.91.22.2-1.2-1.2-1.3-0.5
K content in liver0.30.30.7-0.3-0.3-0.4-0.4-0.30.90.7-0.7-0.7-0.6-0.2
Mg content in liver0.10.10.2-0.4-0.4-0.20.30.30.1-0.1-0.0-0.0-0.30.0
Mn content in liver0.40.51.30.60.71.00.40.6-0.2-1.10.70.70.50.4
Na content in liver0.30.30.8-0.9-0.9-0.6-0.1-0.10.30.4-0.5-0.5-0.7-0.4
Rb content in liver0.40.51.61.31.20.7-0.8-0.60.70.5-0.4-0.40.40.3
Se content in liver3.84.58.3-1.4-2.0-2.4-1.6-1.71.92.9-2.6-2.6-2.0-1.4
Sr content in liver1.21.01.90.30.40.81.21.2-1.3-1.41.21.20.80.7
Zn content in liver1.21.34.4-0.7-0.3-0.22.11.7-1.2-0.71.21.20.21.1
Bone: minimum diameter0.00.00.0-0.10.10.1-0.00.0-0.1-0.20.10.10.1-0.1
Time in familiar zone, hab. session 12.32.23.21.71.41.61.21.4-1.7-1.51.31.31.81.5
Time in novel zone, hab. session 11.11.11.8-1.3-1.2-1.1-0.8-0.91.10.9-0.9-0.9-1.3-1.1
Total zone transitions, hab. session 10.40.61.70.00.30.1-1.3-1.21.30.5-0.6-0.6-0.5-0.8
Total locomotion distance, hab. session 10.50.81.6-0.1-0.2-0.4-1.2-1.11.11.0-1.0-1.0-0.6-0.8
Locomotion velocity, hab. session 10.71.02.40.10.1-0.3-1.6-1.41.31.1-1.1-1.1-0.6-0.9
Time in familiar zone, hab. session 20.10.10.50.70.10.3-0.00.2-0.6-0.2-0.1-0.10.50.2
Time in novel zone, hab. session 20.20.20.7-0.5-0.0-0.3-0.5-0.50.80.4-0.2-0.2-0.5-0.4
Total zone transitions, hab. session 20.10.10.4-0.6-0.4-0.2-0.2-0.30.3-0.30.10.1-0.4-0.6
Total locomotion distance, hab. session 20.10.10.30.00.00.0-0.5-0.50.40.0-0.1-0.1-0.2-0.4
Locomotion velocity, hab. session 20.10.10.20.00.10.1-0.5-0.50.4-0.1-0.0-0.0-0.1-0.4
Novel to familiar place preference ratio0.10.10.3-0.3-0.20.0-0.4-0.40.4-0.2-0.1-0.1-0.3-0.6
Novelty place preference0.10.10.3-0.10.00.2-0.5-0.40.4-0.2-0.1-0.1-0.2-0.5
Time in novel zone, NPP test0.10.10.3-0.3-0.10.0-0.5-0.40.4-0.1-0.1-0.1-0.3-0.5
Total zone transitions, NPP test0.20.30.6-0.8-0.4-0.5-0.5-0.60.70.4-0.4-0.4-0.7-0.6
Total locomotion distance, NPP test1.31.82.8-0.9-0.9-1.2-1.4-1.51.51.7-1.5-1.5-1.3-1.2
Locomotion velocity, NPP test1.31.82.7-1.1-0.9-1.3-1.3-1.51.51.6-1.3-1.3-1.3-1.2
Intraocular pressure0.30.51.4-0.9-0.6-1.21.00.5-0.50.90.10.0-0.20.4
Delta distance traveled before/after self-admin0.50.51.1-0.20.30.31.00.8-1.0-0.80.90.90.60.6
Delta ambulatory time before/after self-admin0.60.71.10.50.90.80.80.8-1.0-0.90.90.91.00.7
Parametrial fat weight0.00.10.20.4-0.30.0-0.10.1-0.30.1-0.5-0.50.20.1
Pavlov. Cond. lever latency0.40.51.3-0.8-0.8-0.31.21.0-0.3-0.60.60.6-0.40.3
Pavlov. Cond. magazine entry latency0.50.61.1-0.8-1.0-1.1-0.6-0.80.00.9-0.7-0.7-0.6-0.9
Pavlov. Cond. change in total contacts1.31.42.9-0.2-0.7-0.7-1.7-1.60.91.1-1.5-1.5-0.7-1.4
Pavlov. Cond. index score0.40.51.0-0.2-0.4-0.7-0.9-1.00.31.0-0.9-0.9-0.3-0.7
Pavlov. Cond. latency score0.50.71.4-0.1-0.3-0.6-1.2-1.20.41.0-1.0-1.0-0.3-0.8
Pavlov. Cond. lever contacts0.40.51.50.80.50.2-1.2-1.00.40.6-0.7-0.70.2-0.4
Pavlov. Cond. magazine entry number0.81.01.71.01.11.30.71.0-0.3-1.31.01.00.70.9
Pavlov. Cond. intertrial magazine entries0.40.41.30.61.11.00.20.40.1-0.60.60.60.50.6
Pavlov. Cond. lever-magazine prob. diff.0.40.40.8-0.0-0.4-0.6-0.9-0.90.20.9-0.9-0.9-0.2-0.6
Pavlov. Cond. response bias0.60.71.4-0.7-0.8-1.0-0.7-0.90.31.2-0.9-0.9-0.6-0.8
Pavlov. Cond. lever latency1.62.14.21.10.81.21.51.5-2.0-1.61.51.51.61.3
Pavlov. Cond. magazine entry latency2.02.45.0-0.2-0.5-0.8-2.2-2.02.01.5-1.8-1.8-1.2-1.6
Pavlov. Cond. change in total contacts0.81.22.6-1.0-0.5-0.9-1.2-1.31.61.1-0.9-0.9-1.2-1.1
Pavlov. Cond. index score1.62.14.2-0.7-0.5-0.9-1.8-1.82.01.6-1.5-1.5-1.3-1.4
Pavlov. Cond. latency score1.62.13.8-0.6-0.5-0.9-1.8-1.82.01.6-1.5-1.5-1.3-1.4
Pavlov. Cond. lever contacts1.92.65.0-1.1-0.9-1.4-1.7-1.72.21.9-1.7-1.7-1.7-1.4
Pavlov. Cond. magazine entry number1.31.63.60.20.20.51.91.7-1.8-1.11.31.31.01.3
Pavlov. Cond. intertrial magazine entries0.10.20.7-0.9-0.5-0.50.60.3-0.4-0.00.30.3-0.20.1
Pavlov. Cond. lever-magazine prob. diff.1.82.44.8-0.7-0.5-1.0-2.0-1.92.21.6-1.6-1.6-1.4-1.5
Pavlov. Cond. response bias2.53.46.7-1.1-0.8-1.4-2.1-2.12.62.1-1.9-1.9-1.8-1.6
Time in closed arm before self-admin0.40.51.5-1.2-0.6-0.41.00.6-0.6-0.60.70.7-0.30.0
Time in closed arm after self-admin0.70.73.6-1.9-1.3-1.00.2-0.20.10.10.20.2-0.9-0.8
Time in open arm before self-admin0.70.81.1-0.7-0.8-0.7-1.0-1.11.00.8-0.8-0.8-0.9-1.0
Time in open arm after self-admin0.30.31.31.10.70.4-0.6-0.30.30.4-0.5-0.50.30.2
Bone: periosteal estimation0.40.93.0-1.7-1.5-1.50.40.00.20.8-0.4-0.4-1.1-0.5
Bone: periosteal perimeter1.42.34.3-1.7-1.6-2.1-0.8-1.11.42.1-1.4-1.5-1.7-1.1
Bone: post-yield work0.10.10.5-0.3-0.2-0.60.50.2-0.10.7-0.0-0.0-0.10.4
Progressive ratio test 1 active lever presses0.40.41.3-1.1-0.9-1.0-0.2-0.40.20.4-0.4-0.4-0.8-0.8
Progressive ratio test 1 breakpoint0.40.51.3-1.1-1.0-1.0-0.2-0.40.20.4-0.4-0.4-0.8-0.8
Progressive ratio test 1 inactive lever presses0.40.61.5-0.30.20.21.20.9-0.9-0.81.11.10.40.6
Progressive ratio test 2 active lever presses0.20.31.2-1.1-0.7-0.60.1-0.30.2-0.00.10.1-0.7-0.6
Progressive ratio test 2 breakpoint0.20.31.1-1.1-0.7-0.60.1-0.30.2-0.00.10.1-0.7-0.6
Progressive ratio test 2 inactive lever presses0.61.03.2-1.0-0.3-0.41.81.1-1.2-0.41.21.20.00.8
Incentive Sensitization - Responses0.00.10.20.10.20.30.10.00.2-0.40.30.3-0.10.1
Incentive Sensitization - Breakpoint0.00.10.20.10.30.40.10.00.3-0.40.30.3-0.10.1
Sum of active levers in priming session hrs 5-60.20.20.50.2-0.3-0.3-0.4-0.20.50.5-0.7-0.7-0.4-0.2
Progressive ratio0.30.41.00.90.71.0-0.10.2-0.3-0.90.50.50.80.2
Food seeking constrained by brief footshock4.04.96.22.42.52.31.82.2-2.1-1.92.12.12.52.4
Seeking ratio, punishment vs. effort0.10.20.8-0.30.0-0.20.90.7-0.5-0.10.40.40.00.6
Retroperitoneal fat weight0.31.53.50.0-0.8-0.8-1.4-0.91.21.5-1.9-1.9-0.9-0.8
Reaction time number correct0.51.02.3-0.60.50.31.51.3-1.0-0.81.31.30.51.0
Reaction time mean minus median3.68.912.1-2.3-2.6-3.0-3.0-3.22.83.5-3.3-3.3-2.8-2.9
Reaction time mean minus median AUC1.12.84.4-1.1-1.1-1.5-1.9-2.11.82.1-1.8-1.8-1.5-1.6
Reaction time num false alarms1.11.62.4-1.0-0.7-1.1-1.4-1.61.41.4-1.2-1.2-1.2-1.4
Reaction time num false alarms AUC0.61.01.8-0.8-0.5-1.0-1.0-1.21.01.3-1.0-1.0-0.9-0.9
Reaction time trials correct on left0.51.02.3-0.60.50.31.51.3-1.0-0.81.31.30.51.0
Reaction time trials on left0.50.92.1-0.60.50.21.41.3-0.9-0.71.21.20.40.9
Reaction time mean1.93.08.10.4-0.5-0.4-2.9-2.42.01.3-2.1-2.1-1.0-1.9
Reaction time mean AUC1.72.77.30.4-0.4-0.4-2.7-2.31.81.3-2.0-1.9-0.9-1.7
Median of all reaction times1.11.65.41.40.40.6-2.3-1.71.30.3-1.3-1.2-0.2-1.2
Reaction time omissions1.01.52.8-0.3-0.6-0.8-1.7-1.51.21.4-1.5-1.5-0.9-1.2
Reaction time false alarm rate1.52.13.3-0.6-0.9-1.2-1.7-1.81.41.7-1.6-1.6-1.2-1.4
Reaction time premature initiation rate0.91.31.8-0.7-1.1-1.1-1.2-1.30.91.3-1.2-1.2-0.9-1.2
Reaction time premature initiations0.20.40.7-0.8-0.7-0.8-0.4-0.60.40.7-0.5-0.5-0.5-0.6
Std. dev. reaction times2.85.28.0-1.0-1.6-1.8-2.8-2.82.22.5-2.7-2.7-1.9-2.4
Reaction time trials completed0.50.92.1-0.60.50.21.41.3-0.9-0.71.21.20.40.9
Reaction time trials AUC0.40.91.9-0.50.60.31.41.2-0.9-0.71.21.20.51.0
Run reversals in cocaine runway, females0.40.41.10.91.10.80.20.4-0.1-0.30.30.30.60.7
Run reversals in cocaine runway, males0.40.41.00.10.60.50.60.5-0.4-0.61.01.00.40.5
Latency to leave start box in cocaine runway0.10.10.30.1-0.30.1-0.6-0.30.4-0.2-0.4-0.4-0.3-0.5
Latency to leave start box in cocaine runway, F0.10.10.70.2-0.40.4-0.00.2-0.2-0.80.00.0-0.0-0.2
Latency to leave start box in cocaine runway, M0.10.10.3-0.00.2-0.1-0.5-0.50.50.5-0.3-0.3-0.2-0.3
Std. dev. time between licks in bursts0.20.20.6-0.7-0.5-0.8-0.1-0.50.00.7-0.2-0.2-0.3-0.3
Total sessions with >9 infusions0.10.20.50.70.50.6-0.10.0-0.4-0.40.10.10.50.2
Short access day 1 total inactive lever presses0.81.11.70.80.70.71.21.3-1.3-0.81.01.01.01.2
Short access day 10 total inactive lever presses1.43.56.61.10.51.12.62.5-2.6-1.81.91.91.62.0
Short access day 1 total infusions0.60.82.21.51.31.20.10.4-0.7-0.70.40.41.10.8
Short access day 10 total infusions0.10.10.30.50.60.2-0.1-0.3-0.20.4-0.2-0.20.40.4
Short access total infusions0.20.31.21.10.70.6-0.6-0.3-0.0-0.1-0.4-0.30.50.0
Short access day 1 locomotion1.11.32.6-0.6-0.5-0.8-1.5-1.61.31.2-1.2-1.2-0.9-1.2
Short access day 10 total locomotion0.50.91.40.71.00.61.10.9-1.1-0.51.00.91.01.2
Short access total locomotion0.20.30.80.50.2-0.0-0.8-0.90.40.6-0.6-0.6-0.0-0.3
One hour access (0.3 mA shock)0.40.51.2-0.90.1-0.21.10.6-0.6-0.51.11.1-0.00.3
Compulsive drug intake0.70.82.11.31.51.40.00.3-0.0-0.90.70.70.80.6
One hour access (shock baseline)0.91.34.4-2.1-1.4-1.7-0.1-0.70.61.1-0.6-0.6-1.3-1.0
Social response proportion4.75.310.3-3.2-3.2-2.7-1.3-1.71.71.5-1.8-1.8-2.7-2.7
Social responses1.31.64.7-2.2-1.7-1.9-0.2-0.80.51.4-0.7-0.7-1.3-1.0
Social time0.50.72.60.50.30.4-1.6-1.51.00.1-0.6-0.6-0.2-1.0
Soleus weight0.31.02.9-1.6-1.2-1.71.10.5-0.31.3-0.1-0.2-0.60.3
Bone: stiffness1.11.82.7-1.7-1.6-1.6-0.8-1.21.31.2-1.0-1.0-1.6-1.3
Tibialis anterior weight2.68.821.6-4.5-4.6-4.60.1-0.80.93.1-2.1-2.2-3.1-2.0
Time to tail flick, vehicle, before self-admin1.81.84.1-0.1-0.8-0.4-2.0-1.71.70.8-1.6-1.6-1.1-1.6
Time to tail flick, vehicle, after self-admin0.40.50.9-0.7-0.7-0.5-0.7-0.80.90.5-0.6-0.6-1.0-0.8
Time to tail flick, test, before self-admin0.30.31.4-1.2-0.8-0.40.50.3-0.3-0.40.30.3-0.4-0.3
Time to tail flick, test, after self-admin0.30.30.70.2-0.40.0-0.9-0.60.50.2-0.6-0.6-0.3-0.6
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.10.40.10.50.3-0.20.00.40.40.10.5
Delta time to tail flick, test, before/after SA0.30.31.71.30.80.7-0.3-0.0-0.20.0-0.0-0.00.70.5
Tibia length0.51.46.4-1.7-2.5-1.50.90.6-1.0-0.4-0.2-0.2-0.8-0.9
Ambulatory time before self-admin0.50.81.6-0.2-0.4-0.7-1.0-1.11.11.3-1.0-1.0-0.8-0.6
Ambulatory time after self-admin0.10.10.4-0.10.2-0.3-0.4-0.50.30.7-0.3-0.3-0.1-0.1
Bone: tissue strength2.42.43.11.31.31.41.71.8-1.6-1.51.61.61.51.7
Total heroin consumption1.41.63.80.30.4-0.5-1.8-1.71.91.5-1.4-1.4-0.8-0.9
Bone: trabecular number0.50.92.3-1.5-1.1-1.21.41.0-0.50.60.10.1-0.60.6
Bone: trabecular spacing0.81.13.71.91.61.4-0.4-0.0-0.5-0.70.40.41.40.6
Bone: trabecular thickness0.91.13.3-1.6-1.5-1.81.00.5-0.21.4-0.5-0.5-0.80.2
Bone: trabecular tissue density5.78.511.2-2.0-2.6-2.6-3.3-3.32.82.7-3.2-3.2-2.7-3.3
Water consumed over 24 hours0.50.61.5-1.2-0.5-0.41.21.1-0.5-0.70.80.8-0.20.2
Number of responses in last shaping day0.10.10.30.50.50.3-0.3-0.20.1-0.0-0.1-0.10.20.0