Hub : Genes

Pnpla3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Pnpla3 0.05 0.04 6.6e-03 0.01 0.03 0.02 0.02 6.2e-02 1.1e-02 2.2e-02 3.1e-02
2 Brain mRNA stability Pnpla3 0.06 0.04 6.2e-07 0.06 0.04 0.06 0.01 6.6e-06 9.8e-05 4.0e-06 7.0e-02
3 Liver gene expression Pnpla3 0.07 0.05 1.5e-04 0.03 0 0.02 0.01 3.1e-04 2.0e-01 2.3e-03 7.1e-03
4 Eye gene expression Pnpla3 0.63 0.17 1.5e-07 0.37 0.36 0.31 0.36 9.1e-07 1.3e-06 1.2e-05 1.4e-06
5 Adipose mRNA stability Pnpla3 0.07 0.04 7.3e-07 0.05 0.02 0.05 0.02 1.3e-06 1.1e-03 2.0e-06 3.3e-03
6 Adipose gene expression Pnpla3 0.43 0.16 0.0e+00 0.21 0.1 0.23 0.09 1.6e-22 2.0e-11 5.3e-25 8.6e-10
7 BLA gene expression Pnpla3 0.12 0.08 4.8e-03 0.06 0.03 0.04 0.04 6.3e-04 1.2e-02 2.9e-03 2.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.30.61.0-0.91.0-0.70.51.00.4-0.7
Area under the delay curve2.12.23.1-1.81.6-1.61.61.31.7-0.2
BMI with tail1.96.07.12.6-2.42.5-2.7-2.4-2.32.2
BMI without tail1.22.54.41.9-2.11.5-1.7-1.7-1.4-0.1
Body weight0.93.65.62.4-2.02.1-2.2-1.7-1.80.8
Weight adjusted by age0.50.60.90.9-1.00.9-0.6-0.8-0.80.4
Bone surface0.10.10.4-0.30.6-0.10.20.70.0-0.2
Bone volume0.10.10.3-0.30.5-0.20.10.6-0.1-0.3
Breakpoint value in progressive ratio session0.30.30.50.5-0.70.5-0.5-0.7-0.50.1
Number of licking bursts1.11.32.9-0.70.7-1.21.20.91.7-1.1
Context. condit. distance diff. score3.44.16.32.5-2.32.1-2.0-2.1-1.41.5
Locomotion velocity, session 12.32.43.61.4-1.41.7-1.8-1.3-1.91.4
Locomotion distance, session 10.10.10.3-0.30.4-0.10.00.4-0.00.5
Locomotion velocity, session 23.74.36.02.2-2.42.2-2.2-2.0-2.40.1
Locomotion distance, session 20.10.20.5-0.60.4-0.10.10.2-0.40.7
Locomotion velocity, session 32.02.43.61.7-1.91.6-1.6-1.5-1.60.1
Locomotion distance, session 30.30.31.8-0.2-0.0-0.40.40.40.1-1.4
Stereotopy head waving bouts, day 33.03.54.81.5-1.82.0-2.1-2.0-2.21.3
Stereotopy head waving duration, day 34.95.97.32.6-2.62.7-2.7-2.5-2.21.4
Locomotion velocity, session 70.40.41.10.7-1.00.4-0.5-1.0-0.4-0.1
Locomotion distance, session 70.10.10.2-0.50.2-0.40.40.10.0-0.0
Stereotopy head waving bouts, day 75.25.98.32.9-2.92.6-2.5-2.6-2.20.6
Stereotopy head waving duration, day 72.12.64.62.2-2.01.7-1.7-1.6-1.2-0.1
Locomotion velocity, session 89.911.813.43.6-3.63.7-3.5-3.5-3.62.4
Locomotion distance, session 82.02.93.71.9-1.91.8-1.7-1.7-1.81.2
Degree of sensitization distance1.11.13.60.6-0.60.9-0.9-1.0-0.81.9
Degree of sensitization stereotypy2.32.54.62.2-1.91.7-1.6-1.4-1.2-0.0
Conditioned locomotion0.81.02.2-0.50.8-1.00.90.91.5-0.9
Cocaine response after cond. corrected0.20.21.10.1-0.2-0.30.30.00.6-1.1
Cocaine response after cond. not corrected0.40.42.10.2-0.2-0.50.40.10.7-1.5
Cocaine response before conditioning0.20.30.5-0.50.5-0.70.50.60.4-0.3
Saline control response0.10.10.60.1-0.1-0.10.20.20.3-0.8
Bone: connectivity density0.20.30.6-0.60.7-0.40.40.70.4-0.5
Bone: cortical apparent density0.81.02.2-1.51.3-1.00.90.80.70.6
Bone: cortical area0.20.31.11.0-0.70.6-0.7-0.4-0.10.1
Bone: cortical porosity0.10.10.20.5-0.30.1-0.2-0.00.1-0.2
Bone: cortical porosity0.20.30.70.8-0.70.4-0.5-0.3-0.1-0.2
Bone: cortical thickness0.30.50.9-0.70.9-0.60.40.60.70.7
Bone: cortical thickness0.10.10.70.00.2-0.2-0.2-0.10.30.9
Bone: cortical tissue density0.60.81.8-1.31.1-0.80.80.60.50.7
Condit. Reinf. active minus inactive responses2.02.23.5-1.61.5-1.81.61.31.9-0.1
Condit. Reinf. active-inactive response ratio1.41.54.0-0.91.1-1.41.20.92.00.1
Condit. Reinf. active responses2.42.94.2-2.01.7-2.01.81.51.8-0.7
Condit. Reinf. inactive responses0.60.71.6-1.30.8-0.90.90.80.1-0.7
Incentive salience index mean2.12.53.6-1.91.6-1.91.71.41.7-0.3
Condit. Reinf. lever presses0.70.92.0-1.41.0-1.21.10.70.6-0.3
Condit. Reinf. active minus inactive responses0.10.20.9-0.20.20.3-0.1-0.1-0.20.9
Condit. Reinf. active-inactive response ratio0.10.10.3-0.10.10.3-0.1-0.2-0.10.6
Condit. Reinf. active responses0.81.11.90.7-0.71.2-1.0-0.9-1.11.4
Condit. Reinf. inactive responses1.11.41.81.1-0.91.2-1.3-1.1-1.31.3
Condit. Reinf. lever presses0.40.51.00.3-0.60.6-0.6-0.9-1.00.8
Condit. Reinf. lever reinforcers received0.40.61.30.3-0.30.8-0.7-0.6-1.01.2
Conditioned reinforcement - actives0.50.51.0-0.91.0-0.40.80.80.4-0.0
Conditioned reinforcement - inactives0.10.10.4-0.1-0.10.1-0.0-0.2-0.10.6
Conditioned locomotion1.51.82.91.4-1.71.7-1.3-1.3-1.40.2
Patch foraging indifference point 0 sec0.10.10.3-0.40.5-0.30.40.50.1-0.1
Patch foraging indifference point AUC0.10.10.3-0.50.4-0.20.2-0.1-0.10.5
Delay disc. indifference point, 0s delay0.20.20.30.6-0.60.1-0.4-0.50.2-0.3
Delay disc. indifference point, 16s delay2.42.43.8-2.01.8-1.51.81.51.2-0.6
Delay disc. indifference point, 2s delay0.60.71.8-0.90.5-1.00.80.61.30.2
Delay disc. indifference point, 24s delay0.50.50.9-0.90.8-0.81.00.30.60.1
Delay disc. indifference point, 4s delay0.30.30.9-0.60.5-0.30.20.20.81.0
Delay disc. indifference point, 8s delay2.93.03.9-2.01.9-1.81.91.61.8-0.6
Indifference point function ln k0.91.22.31.5-1.31.2-1.2-0.8-1.1-0.4
Indifference point function log k0.91.22.31.5-1.31.2-1.2-0.8-1.1-0.4
Patch foraging total patch changes 0 sec0.20.30.4-0.60.7-0.50.60.60.5-0.4
Patch foraging total patch changes 12 sec0.10.21.0-0.00.10.1-0.1-0.4-0.11.0
Patch foraging total patch changes 18 sec0.40.51.2-1.01.1-0.60.60.90.50.2
Patch foraging total patch changes 24 sec0.10.10.40.1-0.20.1-0.2-0.1-0.5-0.6
Patch foraging total patch changes 6 sec0.30.40.8-0.60.9-0.60.60.50.70.4
Patch foraging time to switch 0 sec0.10.10.5-0.0-0.20.2-0.1-0.1-0.7-0.2
Patch foraging water rate 0 sec0.20.20.70.8-0.60.4-0.5-0.50.00.1
Patch foraging water rate 12 sec0.60.92.01.3-1.20.6-0.8-0.6-0.4-1.4
Patch foraging water rate 18 sec0.10.10.2-0.10.2-0.30.00.40.4-0.4
Patch foraging water rate 24 sec1.21.72.41.5-1.51.4-1.5-1.1-1.30.0
Patch foraging water rate 6 sec0.20.30.6-0.40.4-0.50.50.60.6-0.7
Seeking ratio, delayed vs. immediate footshock1.71.92.5-1.51.2-1.61.51.31.0-1.6
Distance traveled before self-admin0.00.00.1-0.20.2-0.00.1-0.0-0.20.4
Distance traveled after self-admin0.91.01.40.7-0.91.1-1.0-1.2-1.20.6
Extensor digitorum longus weight0.20.81.41.0-1.20.8-0.8-1.0-0.8-0.3
Bone: elastic displacement1.31.52.41.5-1.51.2-1.2-1.3-1.0-0.1
Bone: elastic work4.96.38.73.0-2.92.7-2.6-2.6-2.30.8
Bone: endosteal estimation3.06.610.43.2-3.12.7-2.6-2.4-2.40.1
Bone: endosteal perimeter2.04.17.62.7-2.62.0-1.9-1.7-1.6-1.1
Epididymis fat weight0.40.91.31.1-1.11.1-0.9-0.8-0.80.4
Delta time in closed arm before/after self-admin0.20.21.5-0.20.20.1-0.2-0.1-0.11.2
Delta time in open arm before/after self-admin1.11.02.61.3-1.60.6-0.8-1.0-0.6-0.8
Diff in mean of infusions in LGA sessions1.51.63.7-1.61.9-0.90.91.40.51.3
Delay discount exponential model param2.02.13.11.8-1.61.6-1.6-1.2-1.7-0.0
Extinction: sum of active levers before priming0.10.10.5-0.1-0.2-0.20.0-0.70.30.4
Active lever presses in extinction session 60.40.40.90.6-0.60.4-0.5-0.60.20.9
Bone: final force0.71.13.10.9-0.71.0-1.1-0.9-0.71.8
Bone: final moment1.11.74.11.2-0.91.3-1.4-1.1-0.92.0
Food consumed during 24 hour testing period1.92.33.61.6-1.21.6-1.7-1.4-1.21.9
Glucose1.82.84.0-1.82.0-1.71.61.81.8-0.6
Heart weight0.20.20.60.7-0.40.5-0.3-0.20.40.8
Delay discount hyperbolic model param1.51.62.41.5-1.31.3-1.3-1.0-1.5-0.1
Intermittent access intake day 1-15 change0.60.61.1-0.80.8-0.70.81.00.3-0.6
Intermittent access intake escalation0.50.51.0-0.60.6-0.70.80.80.4-1.0
Intermittent access intake escalation 20.50.51.1-0.70.8-0.50.71.10.3-0.3
Intermitt. access day 1 inactive lever presses1.92.02.71.3-1.41.3-1.7-1.6-0.91.6
Intermitt. access day 15 inactive lever presses1.71.84.50.9-1.01.1-1.5-1.5-0.92.1
Intermitt. access escalation Index0.10.10.20.0-0.20.2-0.1-0.4-0.2-0.3
Intermittent access day 1 total infusions0.40.51.00.7-0.51.0-0.6-0.5-0.60.7
Intermittent access day 15 total infusions0.10.10.30.3-0.20.5-0.20.1-0.5-0.2
Intermittent access terminal intake (last 3 days)0.20.20.50.3-0.20.7-0.3-0.0-0.70.3
Intermittent access total infusions0.20.20.60.6-0.40.8-0.4-0.2-0.6-0.0
Intermittent access day 1 locomotion0.10.10.20.2-0.30.3-0.1-0.1-0.1-0.4
Intermittent access day 15 total locomotion0.50.51.20.9-1.10.7-0.5-0.6-0.5-0.5
Intermittent access total locomotion0.70.81.51.1-1.21.0-0.8-0.9-0.80.1
Intermittent access standard deviation0.60.71.00.8-0.71.0-0.6-0.7-1.00.9
Left kidney weight14.340.148.06.9-6.96.8-6.6-6.5-6.04.2
Right kidney weight15.342.950.57.1-6.97.0-6.8-6.7-6.24.7
Cocaine induced anxiety3.54.15.12.2-2.21.9-2.2-2.2-1.81.5
Post-drug Anxiety1.92.12.81.6-1.71.3-1.6-1.6-1.01.3
Baseline Anxiety3.03.24.2-2.11.9-1.71.91.81.6-1.2
Tail length0.10.31.6-0.20.2-0.30.20.50.3-1.3
Length with tail0.00.10.20.3-0.10.4-0.30.0-0.3-0.4
Length without tail0.40.82.20.4-0.21.0-0.9-0.6-1.21.5
Times rat made contact with spout0.91.01.91.0-0.81.0-1.1-0.9-0.61.4
Lifetime Intake0.40.51.00.8-0.61.0-0.6-0.4-0.80.1
Liver weight, left0.20.30.70.4-0.50.6-0.6-0.6-0.40.8
Liver weight, right0.00.10.20.3-0.30.3-0.1-0.0-0.1-0.5
Locomotor activity1.11.83.21.8-1.61.4-1.5-1.3-0.90.7
Locomotor testing distance0.00.00.1-0.00.1-0.10.10.20.30.0
Locomotor testing rearing0.10.20.70.7-0.80.3-0.3-0.50.10.2
Locomotion in novel chamber0.80.96.0-0.1-0.2-0.10.60.20.1-2.5
Locomotion in novel chamber post-restriction0.70.91.4-0.80.7-1.10.90.90.7-1.2
Fecal boli incidents, locomotor time 10.10.10.40.1-0.50.1-0.2-0.6-0.30.4
Change in fecal boli incidents, locomotor task0.20.20.90.3-0.1-0.20.10.30.5-0.9
Time >=10cm from walls, locomotor time 10.20.30.40.5-0.40.6-0.6-0.4-0.70.3
Bouts of movement, locomotor time 10.00.10.1-0.30.2-0.00.30.1-0.00.4
Total resting periods, locomotor time 10.10.10.4-0.60.4-0.20.50.20.10.4
Rest time, locomotor task time 10.40.51.10.4-1.00.6-0.2-1.0-0.70.5
Distance moved, locomotor task time 10.00.00.10.10.20.1-0.30.3-0.10.1
Vertical activity count, locomotor time 10.20.20.6-0.20.7-0.10.00.80.20.1
Time >=10cm from walls, locomotor time 20.10.10.6-0.30.2-0.30.20.20.2-0.8
Bouts of movement, locomotor time 20.90.92.2-0.91.0-1.20.70.61.50.2
Total resting periods, locomotor time 20.91.02.1-1.01.1-1.30.80.61.50.4
Rest time, locomotor task time 20.20.20.5-0.50.3-0.60.70.10.3-0.1
Distance moved, locomotor task time 20.81.01.51.2-1.21.1-1.2-0.8-0.80.0
Vertical activity count, locomotor time 21.11.21.81.3-1.31.1-1.3-0.9-1.10.1
Light reinforcement 11.22.23.11.5-1.81.6-1.5-1.4-1.7-0.4
Light reinforcement 21.62.23.41.6-1.81.5-1.3-1.6-1.5-0.9
Bone: marrow area3.16.810.83.3-3.12.8-2.7-2.5-2.40.2
Bone: maximum diameter3.56.511.53.4-3.02.6-2.7-2.4-2.10.5
Bone: maximum force1.42.43.51.8-1.41.6-1.7-1.4-1.11.9
Bone: maximum moment1.93.34.52.1-1.61.9-2.0-1.6-1.22.1
Mean time between licks in bursts2.83.95.2-1.61.9-2.02.02.12.3-1.8
Mean num. licks in bursts3.13.75.11.6-1.52.0-2.1-1.7-2.32.2
Cd content in liver0.50.52.60.10.4-0.50.50.51.60.2
Co content in liver1.11.22.01.1-1.21.2-1.2-0.9-1.40.4
Cu content in liver5.16.17.4-2.62.4-2.52.62.51.9-2.7
Fe content in liver0.10.20.30.4-0.40.6-0.5-0.4-0.30.1
K content in liver0.70.71.5-0.0-0.30.7-0.7-0.8-1.21.1
Mg content in liver0.20.20.6-0.50.10.3-0.2-0.3-0.80.7
Mn content in liver0.91.01.50.8-1.11.0-1.0-1.1-1.20.3
Na content in liver3.73.95.4-2.12.2-2.12.11.92.3-0.7
Rb content in liver0.30.40.7-0.60.7-0.50.60.60.80.0
Se content in liver0.20.20.6-0.60.4-0.20.00.3-0.8-0.6
Sr content in liver0.60.50.6-0.80.7-0.80.80.70.6-0.6
Zn content in liver0.91.01.3-1.01.0-1.01.01.20.7-1.1
Bone: minimum diameter0.71.32.21.5-1.31.1-1.0-0.6-1.1-1.3
Time in familiar zone, hab. session 11.00.91.20.9-1.01.1-1.0-1.1-1.10.5
Time in novel zone, hab. session 10.40.41.6-0.00.4-0.60.50.61.2-0.4
Total zone transitions, hab. session 11.42.03.0-1.71.7-1.41.41.61.0-0.4
Total locomotion distance, hab. session 10.20.21.00.0-0.40.3-0.3-0.4-1.0-0.4
Locomotion velocity, hab. session 10.20.31.50.1-0.50.4-0.4-0.5-1.2-0.2
Time in familiar zone, hab. session 20.10.10.20.0-0.3-0.1-0.0-0.3-0.1-0.5
Time in novel zone, hab. session 20.10.10.20.10.30.10.00.40.40.5
Total zone transitions, hab. session 20.81.02.30.4-0.60.9-0.9-0.7-1.31.5
Total locomotion distance, hab. session 20.40.61.40.4-0.80.7-0.7-0.8-1.20.5
Locomotion velocity, hab. session 20.30.51.40.2-0.50.6-0.6-0.7-1.20.5
Novel to familiar place preference ratio0.30.31.01.0-0.50.6-0.6-0.2-0.00.1
Novelty place preference0.50.51.61.3-0.70.9-0.8-0.3-0.20.1
Time in novel zone, NPP test0.70.72.11.5-0.90.9-0.9-0.4-0.10.2
Total zone transitions, NPP test0.10.10.5-0.50.3-0.20.10.1-0.30.7
Total locomotion distance, NPP test0.50.71.70.5-0.90.8-0.7-0.9-1.30.1
Locomotion velocity, NPP test0.20.31.1-0.1-0.40.3-0.2-0.4-1.1-0.4
Intraocular pressure0.10.10.20.4-0.20.20.10.10.4-0.3
Delta distance traveled before/after self-admin2.12.23.11.6-1.81.6-1.7-1.5-1.30.5
Delta ambulatory time before/after self-admin1.51.62.31.5-1.51.4-1.3-1.3-1.00.6
Parametrial fat weight0.10.10.5-0.30.10.3-0.2-0.0-0.70.1
Pavlov. Cond. lever latency1.41.83.21.8-1.61.3-1.4-1.5-0.70.8
Pavlov. Cond. magazine entry latency3.24.16.0-2.52.5-2.22.12.11.9-0.3
Pavlov. Cond. change in total contacts3.43.65.2-2.32.3-2.01.92.11.7-0.3
Pavlov. Cond. index score2.22.84.3-2.12.1-1.71.81.81.4-0.2
Pavlov. Cond. latency score1.52.03.1-1.81.7-1.41.51.51.1-0.3
Pavlov. Cond. lever contacts1.92.23.7-1.91.7-1.51.61.60.8-0.9
Pavlov. Cond. magazine entry number3.64.56.32.4-2.52.3-2.2-2.2-2.00.3
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.50.4-0.40.10.40.1-0.2
Pavlov. Cond. lever-magazine prob. diff.2.93.65.3-2.32.3-2.02.02.01.6-0.4
Pavlov. Cond. response bias4.14.97.1-2.72.6-2.42.42.32.0-0.7
Pavlov. Cond. lever latency0.30.41.5-0.00.3-0.60.60.51.2-0.5
Pavlov. Cond. magazine entry latency0.50.61.8-1.41.0-0.50.60.7-0.10.6
Pavlov. Cond. change in total contacts0.60.92.6-0.1-0.10.9-0.9-0.5-1.61.4
Pavlov. Cond. index score0.20.30.6-0.80.50.0-0.00.2-0.80.5
Pavlov. Cond. latency score0.20.30.7-0.80.50.0-0.00.2-0.80.6
Pavlov. Cond. lever contacts0.40.51.70.0-0.30.6-0.7-0.7-1.30.8
Pavlov. Cond. magazine entry number0.30.30.70.8-0.4-0.10.0-0.00.8-0.8
Pavlov. Cond. intertrial magazine entries0.40.61.11.0-0.70.8-0.6-0.8-0.11.0
Pavlov. Cond. lever-magazine prob. diff.0.20.30.9-0.80.40.1-0.00.1-0.90.4
Pavlov. Cond. response bias0.20.30.9-0.40.10.3-0.3-0.4-0.91.0
Time in closed arm before self-admin1.92.12.5-1.61.4-1.61.51.51.2-1.4
Time in closed arm after self-admin0.30.30.5-0.60.6-0.30.50.70.3-0.6
Time in open arm before self-admin0.20.20.3-0.20.5-0.40.40.60.6-0.2
Time in open arm after self-admin0.91.02.21.3-1.50.6-0.8-1.2-0.6-0.3
Bone: periosteal estimation2.04.17.42.7-2.42.1-2.1-1.8-1.60.2
Bone: periosteal perimeter1.52.55.52.4-2.01.5-1.4-1.3-0.8-1.0
Bone: post-yield work0.40.53.00.00.3-0.0-0.1-0.00.51.7
Progressive ratio test 1 active lever presses0.10.10.3-0.40.4-0.20.60.30.20.1
Progressive ratio test 1 breakpoint0.30.30.6-0.70.7-0.40.80.60.4-0.1
Progressive ratio test 1 inactive lever presses0.20.20.50.2-0.60.3-0.2-0.70.10.7
Progressive ratio test 2 active lever presses0.80.82.20.4-0.51.1-0.7-0.7-0.91.5
Progressive ratio test 2 breakpoint0.70.82.40.4-0.51.0-0.7-0.8-0.91.6
Progressive ratio test 2 inactive lever presses0.60.71.90.3-0.40.9-0.8-0.7-0.91.4
Incentive Sensitization - Responses3.13.15.31.3-1.51.9-1.8-1.8-1.72.3
Incentive Sensitization - Breakpoint3.63.75.81.4-1.72.0-1.9-2.0-1.92.4
Sum of active levers in priming session hrs 5-60.30.30.60.6-0.60.6-0.6-0.6-0.70.4
Progressive ratio0.40.50.8-0.80.8-0.40.90.70.70.5
Food seeking constrained by brief footshock0.70.92.00.8-0.81.0-1.0-0.6-1.40.6
Seeking ratio, punishment vs. effort0.81.01.71.0-1.00.9-1.3-0.9-1.30.2
Retroperitoneal fat weight1.13.64.81.8-1.92.2-2.1-1.9-1.91.3
Reaction time number correct1.11.62.6-1.20.9-1.61.31.01.5-1.2
Reaction time mean minus median0.00.10.30.10.1-0.00.30.00.50.3
Reaction time mean minus median AUC0.20.20.60.8-0.60.4-0.2-0.50.20.5
Reaction time num false alarms0.71.02.1-0.50.8-1.10.81.01.4-1.0
Reaction time num false alarms AUC0.40.51.2-0.40.6-0.80.50.71.1-0.6
Reaction time trials correct on left1.11.62.6-1.20.9-1.61.31.01.5-1.2
Reaction time trials on left1.21.72.7-1.30.9-1.71.31.01.6-1.2
Reaction time mean0.40.61.0-0.81.0-0.41.00.80.7-0.1
Reaction time mean AUC0.40.61.1-0.81.0-0.41.00.90.7-0.1
Median of all reaction times0.60.81.6-1.11.3-0.51.21.00.70.0
Reaction time omissions1.11.53.0-1.11.2-1.41.41.01.7-0.1
Reaction time false alarm rate0.00.00.10.20.2-0.1-0.00.20.4-0.0
Reaction time premature initiation rate1.01.34.00.4-0.60.9-0.9-1.2-1.12.0
Reaction time premature initiations0.20.31.7-0.2-0.20.1-0.2-0.6-0.21.3
Std. dev. reaction times0.00.10.2-0.10.30.00.40.20.30.1
Reaction time trials completed1.21.72.7-1.30.9-1.71.31.01.6-1.2
Reaction time trials AUC0.81.21.9-1.00.7-1.41.10.81.3-1.0
Run reversals in cocaine runway, females1.81.74.6-1.31.2-0.81.21.50.5-2.1
Run reversals in cocaine runway, males0.30.20.70.9-0.60.2-0.6-0.30.20.0
Latency to leave start box in cocaine runway1.61.72.61.4-1.41.3-1.3-1.3-1.60.5
Latency to leave start box in cocaine runway, F0.40.51.30.5-0.60.7-0.7-0.6-1.10.5
Latency to leave start box in cocaine runway, M1.71.62.21.4-1.41.5-1.3-1.4-1.30.6
Std. dev. time between licks in bursts0.40.50.8-0.90.9-0.70.80.80.6-0.1
Total sessions with >9 infusions0.10.10.30.4-0.20.40.10.2-0.2-0.6
Short access day 1 total inactive lever presses3.13.44.41.8-1.82.1-1.9-2.0-1.71.6
Short access day 10 total inactive lever presses3.94.35.12.2-2.32.2-2.2-2.2-1.71.5
Short access day 1 total infusions1.01.01.71.0-0.81.2-1.1-0.7-1.30.8
Short access day 10 total infusions0.30.30.5-0.40.5-0.30.70.70.6-0.7
Short access total infusions0.40.50.90.8-0.60.9-0.6-0.5-0.80.3
Short access day 1 locomotion0.10.20.40.1-0.20.7-0.30.0-0.6-0.2
Short access day 10 total locomotion0.70.81.0-0.80.8-1.01.01.00.8-0.8
Short access total locomotion0.10.10.3-0.10.1-0.10.30.30.1-0.5
One hour access (0.3 mA shock)0.00.10.20.1-0.00.4-0.00.2-0.3-0.2
Compulsive drug intake0.20.20.9-0.20.20.3-0.3-0.2-0.20.9
One hour access (shock baseline)0.30.42.00.0-0.0-0.10.50.50.2-1.4
Social response proportion0.40.40.70.5-0.60.6-0.7-0.6-0.90.4
Social responses0.10.10.50.1-0.40.2-0.4-0.3-0.70.3
Social time2.83.75.2-2.32.3-2.11.81.92.00.0
Soleus weight0.20.62.00.5-0.30.6-0.6-0.5-0.71.4
Bone: stiffness0.20.41.10.10.5-0.20.10.50.91.1
Tibialis anterior weight0.00.10.4-0.30.00.10.0-0.0-0.70.0
Time to tail flick, vehicle, before self-admin0.10.10.30.3-0.30.2-0.4-0.3-0.40.5
Time to tail flick, vehicle, after self-admin0.20.20.6-0.20.0-0.40.40.20.6-0.8
Time to tail flick, test, before self-admin0.00.00.10.2-0.2-0.2-0.10.0-0.1-0.3
Time to tail flick, test, after self-admin1.31.32.0-1.41.2-1.31.31.21.0-0.5
Delta time to tail flick, vehicle, before/after SA0.20.20.50.3-0.30.6-0.4-0.4-0.30.7
Delta time to tail flick, test, before/after SA0.80.71.5-1.21.1-0.70.90.80.5-0.2
Tibia length0.20.71.11.0-0.90.7-0.8-0.9-0.50.8
Ambulatory time before self-admin0.10.10.5-0.00.1-0.0-0.2-0.3-0.30.7
Ambulatory time after self-admin0.40.40.50.4-0.60.7-0.7-0.7-0.70.5
Bone: tissue strength0.30.30.60.5-0.50.5-0.5-0.50.10.8
Total heroin consumption0.40.51.00.7-0.50.5-0.7-0.7-0.41.0
Bone: trabecular number0.91.42.3-0.81.1-1.11.01.31.2-1.5
Bone: trabecular spacing2.02.53.51.5-1.71.4-1.5-1.9-1.71.5
Bone: trabecular thickness0.20.20.4-0.60.4-0.10.20.4-0.4-0.6
Bone: trabecular tissue density0.20.30.8-0.90.9-0.40.40.60.10.5
Water consumed over 24 hours2.22.73.92.0-1.61.8-1.8-1.5-1.11.6
Number of responses in last shaping day0.70.71.5-1.21.2-0.60.61.00.30.3