Hub : Genes

Pnpla1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Pnpla1 0.62 0.15 5.0e-16 0.4 0.36 0.45 0.44 9.9e-11 1.4e-09 3.3e-12 7.9e-12
2 NAcc mRNA stability Pnpla1 0.16 0.08 0.0e+00 0.27 0.3 0.3 0.3 9.0e-32 3.8e-35 2.6e-35 1.6e-34
3 PL mRNA stability Pnpla1 0.21 0.09 0.0e+00 0.32 0.34 0.35 0.35 2.4e-35 6.8e-39 3.3e-40 4.2e-40
4 OFC mRNA stability Pnpla1 0.26 0.17 3.2e-05 0.11 0.14 0.15 0.14 1.3e-03 2.7e-04 1.9e-04 2.6e-04
5 PL gene expression Pnpla1 0.47 0.13 0.0e+00 0.6 0.62 0.62 0.62 9.9e-82 1.6e-86 4.9e-86 2.7e-87
6 Brain mRNA stability Pnpla1 0.27 0.11 0.0e+00 0.39 0.41 0.41 0.41 2.4e-38 2.7e-40 1.0e-40 1.2e-40
7 Brain gene expression Pnpla1 0.55 0.16 0.0e+00 0.52 0.51 0.53 0.52 6.3e-56 4.5e-55 6.8e-57 3.8e-56
8 pVTA gene expression Pnpla1 0.58 0.14 0.0e+00 0.51 0.51 0.48 0.5 6.3e-25 6.0e-25 2.3e-23 1.7e-24
9 BLA gene expression Pnpla1 0.5 0.15 0.0e+00 0.5 0.54 0.5 0.52 3.8e-30 1.3e-33 1.2e-30 1.9e-32
10 RMTg gene expression Pnpla1 0.26 0.13 2.8e-08 0.24 0.31 0.28 0.3 4.3e-07 5.8e-09 4.4e-08 1.4e-08
11 Liver gene expression Pnpla1 0.06 0.04 3.4e-10 0.08 0.09 0.08 0.07 1.3e-09 7.7e-10 5.2e-09 1.9e-08
12 Adipose mRNA stability Pnpla1 0.05 0.04 7.3e-09 0.06 0.07 0.06 0.06 2.0e-07 2.4e-08 2.3e-07 1.6e-07
13 NAcc gene expression Pnpla1 0.63 0.16 0.0e+00 0.65 0.66 0.65 0.65 3.1e-99 1.4e-103 1.0e-99 1.1e-100
14 pVTA mRNA stability Pnpla1 0.25 0.13 8.8e-12 0.22 0.21 0.21 0.2 1.1e-09 1.1e-09 1.6e-09 2.9e-09
15 Adipose gene expression Pnpla1 0.23 0.1 0.0e+00 0.35 0.36 0.35 0.35 4.0e-40 2.2e-41 3.4e-40 2.4e-40
16 BLA mRNA stability Pnpla1 0.35 0.17 0.0e+00 0.27 0.32 0.3 0.32 1.1e-14 1.1e-17 2.8e-16 1.5e-17
17 OFC gene expression Pnpla1 0.61 0.14 0.0e+00 0.56 0.58 0.59 0.58 5.6e-16 8.3e-17 3.4e-17 7.3e-17
18 LHb gene expression Pnpla1 0.57 0.14 1.1e-16 0.4 0.38 0.37 0.38 1.1e-10 4.8e-10 1.2e-09 6.8e-10
19 LHb mRNA stability Pnpla1 0.31 0.14 1.5e-08 0.28 0.27 0.27 0.26 2.4e-07 4.4e-07 3.6e-07 7.1e-07
20 Eye gene expression Pnpla1 0.53 0.16 5.6e-06 0.28 0.21 0.15 0.2 2.9e-05 3.4e-04 2.9e-03 5.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density0.50.81.0-0.9-0.9-1.0-1.00.9-0.9-0.90.90.80.90.9-0.90.9-0.8-0.90.8-0.8-0.9-0.90.0
Area under the delay curve0.60.71.20.40.71.01.0-0.70.81.0-1.1-0.8-0.8-0.90.9-0.71.00.8-0.70.71.01.00.0
BMI with tail1.65.26.32.12.32.52.5-2.32.32.4-2.5-2.3-2.3-2.42.3-2.32.52.3-2.22.32.42.40.0
BMI without tail1.22.43.21.51.61.71.7-1.61.61.8-1.6-1.5-1.5-1.51.5-1.51.61.6-1.41.51.81.80.0
Body weight6.025.129.24.85.25.35.3-5.25.25.3-5.3-5.0-5.0-5.15.1-5.05.45.0-5.05.15.25.20.0
Weight adjusted by age0.80.91.50.70.90.70.9-1.00.81.1-1.2-1.0-1.0-1.01.0-1.01.20.9-1.01.01.11.10.0
Bone surface0.00.00.00.10.00.00.0-0.10.10.1-0.0-0.10.00.00.0-0.00.1-0.0-0.10.1-0.1-0.10.0
Bone volume0.00.00.10.10.20.20.2-0.30.20.2-0.2-0.2-0.1-0.10.2-0.20.20.1-0.20.20.10.10.0
Breakpoint value in progressive ratio session0.20.20.4-0.0-0.3-0.5-0.60.5-0.5-0.60.60.40.40.4-0.40.4-0.5-0.40.4-0.5-0.5-0.50.0
Number of licking bursts0.50.60.8-0.8-0.8-0.8-0.80.7-0.8-0.70.90.80.80.8-0.80.7-0.8-0.70.8-0.7-0.6-0.60.0
Context. condit. distance diff. score0.40.50.8-0.9-0.8-0.6-0.60.8-0.7-0.80.60.70.70.7-0.70.7-0.7-0.70.8-0.7-0.7-0.70.0
Locomotion velocity, session 10.80.92.3-1.5-1.2-0.8-0.91.0-1.0-0.80.70.91.00.9-0.90.9-1.0-1.00.9-0.8-0.8-0.80.0
Locomotion distance, session 13.74.76.9-2.6-2.4-2.3-2.32.2-2.2-2.22.12.22.22.2-2.22.2-2.2-2.22.2-2.1-2.1-2.20.0
Locomotion velocity, session 20.20.30.5-0.6-0.6-0.5-0.50.5-0.7-0.50.60.50.60.6-0.60.5-0.6-0.60.6-0.5-0.5-0.50.0
Locomotion distance, session 20.91.31.7-1.3-1.2-1.2-1.21.2-1.2-1.11.11.11.21.1-1.11.2-1.1-1.21.1-1.1-1.1-1.10.0
Locomotion velocity, session 30.50.61.00.30.61.00.9-1.00.80.9-0.7-0.7-0.7-0.70.6-0.80.80.7-0.70.90.80.70.0
Locomotion distance, session 30.30.31.0-1.0-0.8-0.4-0.40.5-0.5-0.40.50.60.60.6-0.60.5-0.6-0.50.7-0.5-0.4-0.40.0
Stereotopy head waving bouts, day 31.92.22.51.41.51.61.6-1.51.61.6-1.5-1.5-1.5-1.51.5-1.51.51.5-1.51.51.61.60.0
Stereotopy head waving duration, day 30.10.10.10.20.30.30.3-0.30.30.3-0.4-0.3-0.3-0.30.3-0.30.30.3-0.30.30.20.20.0
Locomotion velocity, session 70.00.00.2-0.4-0.2-0.0-0.10.1-0.1-0.0-0.00.10.20.1-0.10.2-0.1-0.20.1-0.10.0-0.00.0
Locomotion distance, session 70.91.12.0-1.4-1.2-1.0-1.01.2-1.1-1.00.91.11.11.1-1.01.1-1.0-1.11.1-1.0-0.9-0.90.0
Stereotopy head waving bouts, day 70.50.50.80.40.60.80.8-0.90.80.8-0.7-0.7-0.7-0.70.7-0.80.70.8-0.70.80.70.80.0
Stereotopy head waving duration, day 71.31.62.21.11.21.41.4-1.51.41.4-1.2-1.3-1.3-1.31.2-1.41.21.3-1.31.41.31.30.0
Locomotion velocity, session 80.00.00.1-0.3-0.20.1-0.00.1-0.1-0.10.00.10.10.1-0.10.2-0.1-0.10.2-0.1-0.1-0.10.0
Locomotion distance, session 80.91.41.7-1.3-1.3-1.2-1.21.2-1.1-1.21.11.21.21.2-1.21.2-1.2-1.21.2-1.2-1.1-1.20.0
Degree of sensitization distance0.00.00.20.40.1-0.2-0.10.2-0.1-0.2-0.0-0.00.00.00.10.1-0.0-0.1-0.0-0.1-0.1-0.10.0
Degree of sensitization stereotypy0.00.00.1-0.2-0.00.20.1-0.20.10.2-0.0-0.1-0.1-0.1-0.0-0.20.00.1-0.10.20.10.10.0
Conditioned locomotion3.23.76.02.52.32.12.0-2.02.01.9-1.8-2.0-2.0-1.91.9-2.01.82.0-2.01.91.81.80.0
Cocaine response after cond. corrected0.40.50.70.70.70.70.7-0.70.80.6-0.8-0.7-0.8-0.80.8-0.70.60.8-0.60.70.60.60.0
Cocaine response after cond. not corrected0.40.50.70.70.70.60.7-0.60.80.6-0.8-0.7-0.8-0.80.8-0.70.60.8-0.60.70.70.80.0
Cocaine response before conditioning0.00.00.1-0.00.00.00.00.00.00.1-0.1-0.1-0.1-0.10.1-0.10.10.1-0.10.00.30.30.0
Saline control response0.70.91.51.21.10.80.8-0.80.90.9-0.9-0.9-1.0-1.01.0-0.90.90.9-0.90.91.01.00.0
Bone: connectivity density0.30.50.8-0.6-0.7-0.9-0.80.6-0.8-0.70.80.70.80.8-0.70.7-0.6-0.80.6-0.7-0.8-0.80.0
Bone: cortical apparent density0.00.00.10.30.2-0.00.0-0.10.3-0.1-0.0-0.2-0.2-0.20.2-0.10.20.2-0.20.2-0.1-0.10.0
Bone: cortical area0.10.20.40.10.30.70.6-0.40.50.5-0.7-0.4-0.4-0.40.4-0.40.40.4-0.30.40.60.60.0
Bone: cortical porosity0.00.00.5-0.7-0.4-0.1-0.10.1-0.20.0-0.10.10.20.1-0.10.10.0-0.20.1-0.00.10.00.0
Bone: cortical porosity0.00.10.5-0.7-0.4-0.1-0.10.2-0.2-0.0-0.00.20.20.2-0.20.2-0.1-0.20.2-0.10.0-0.00.0
Bone: cortical thickness0.20.31.0-1.0-0.7-0.4-0.40.6-0.5-0.50.30.50.50.5-0.50.6-0.5-0.50.6-0.5-0.3-0.20.0
Bone: cortical thickness0.00.00.10.20.20.20.2-0.00.10.1-0.2-0.1-0.1-0.10.1-0.10.10.1-0.10.10.20.30.0
Bone: cortical tissue density0.10.10.20.50.30.10.1-0.30.40.0-0.1-0.3-0.3-0.30.3-0.20.30.3-0.30.3-0.0-0.00.0
Condit. Reinf. active minus inactive responses0.80.91.6-1.0-1.0-1.1-1.21.1-1.3-0.90.90.91.01.0-0.91.0-0.9-1.00.9-0.9-0.9-1.00.0
Condit. Reinf. active-inactive response ratio0.10.10.10.1-0.1-0.3-0.30.3-0.4-0.20.20.20.20.2-0.20.2-0.2-0.20.2-0.3-0.2-0.30.0
Condit. Reinf. active responses0.10.20.5-0.4-0.4-0.5-0.60.5-0.7-0.40.30.30.40.4-0.40.4-0.3-0.50.3-0.4-0.4-0.40.0
Condit. Reinf. inactive responses0.10.10.2-0.5-0.4-0.5-0.50.4-0.5-0.40.40.30.40.4-0.30.3-0.1-0.40.2-0.3-0.4-0.30.0
Incentive salience index mean0.30.40.8-0.8-0.7-0.7-0.70.6-0.9-0.50.50.50.60.6-0.60.6-0.5-0.70.5-0.5-0.6-0.60.0
Condit. Reinf. lever presses0.10.10.2-0.5-0.4-0.2-0.30.2-0.4-0.20.20.20.30.3-0.30.2-0.2-0.30.2-0.2-0.3-0.20.0
Condit. Reinf. active minus inactive responses0.60.71.2-0.8-0.9-1.1-1.11.0-0.9-0.90.90.80.90.9-0.80.9-0.8-0.90.8-0.8-0.8-0.80.0
Condit. Reinf. active-inactive response ratio0.20.20.6-0.3-0.5-0.8-0.70.5-0.5-0.50.60.40.50.5-0.50.5-0.4-0.50.4-0.4-0.4-0.50.0
Condit. Reinf. active responses0.60.81.1-0.8-0.9-1.0-1.01.0-1.0-0.90.90.90.90.9-0.90.9-1.0-0.90.9-0.9-0.8-0.80.0
Condit. Reinf. inactive responses0.00.00.10.10.10.30.3-0.20.20.2-0.3-0.1-0.1-0.20.2-0.10.10.1-0.10.10.20.30.0
Condit. Reinf. lever presses3.85.26.3-2.2-2.4-2.4-2.42.5-2.4-2.42.22.32.32.3-2.22.4-2.4-2.32.4-2.4-2.2-2.10.0
Condit. Reinf. lever reinforcers received1.31.92.4-1.3-1.5-1.4-1.41.5-1.5-1.41.31.41.41.4-1.41.4-1.5-1.41.4-1.4-1.3-1.30.0
Conditioned reinforcement - actives0.40.40.80.10.50.70.7-0.60.60.8-0.9-0.7-0.6-0.60.6-0.60.80.6-0.70.70.80.80.0
Conditioned reinforcement - inactives0.10.10.2-0.3-0.4-0.3-0.30.3-0.3-0.30.40.40.30.3-0.40.3-0.3-0.30.4-0.3-0.2-0.20.0
Conditioned locomotion0.40.51.00.30.60.70.8-0.60.60.9-1.0-0.8-0.7-0.70.8-0.70.80.6-0.70.80.90.90.0
Patch foraging indifference point 0 sec0.30.50.80.70.80.80.8-0.70.80.6-0.6-0.7-0.7-0.70.7-0.70.90.7-0.70.70.70.70.0
Patch foraging indifference point AUC0.00.00.0-0.2-0.2-0.0-0.10.1-0.1-0.20.20.20.10.1-0.20.1-0.1-0.10.2-0.1-0.2-0.20.0
Delay disc. indifference point, 0s delay0.00.00.1-0.10.10.20.20.00.10.1-0.3-0.1-0.1-0.10.1-0.1-0.20.10.0-0.00.10.00.0
Delay disc. indifference point, 16s delay0.10.10.6-0.20.10.20.4-0.30.30.5-0.5-0.3-0.3-0.40.4-0.30.70.3-0.30.30.50.50.0
Delay disc. indifference point, 2s delay0.20.20.4-0.6-0.5-0.4-0.30.6-0.6-0.40.20.40.40.4-0.40.5-0.3-0.50.5-0.6-0.4-0.40.0
Delay disc. indifference point, 24s delay2.12.02.90.91.31.51.6-1.41.41.7-1.7-1.4-1.4-1.41.5-1.31.71.3-1.31.41.71.70.0
Delay disc. indifference point, 4s delay1.01.11.51.01.11.21.2-1.01.01.2-1.2-1.0-1.1-1.11.1-1.01.01.0-0.90.91.11.10.0
Delay disc. indifference point, 8s delay1.71.72.61.01.21.61.6-1.31.21.5-1.5-1.3-1.3-1.31.3-1.21.41.2-1.21.21.51.50.0
Indifference point function ln k0.10.20.3-0.6-0.4-0.3-0.40.4-0.4-0.30.40.40.40.4-0.40.4-0.5-0.40.4-0.4-0.3-0.30.0
Indifference point function log k0.10.20.3-0.6-0.4-0.3-0.40.4-0.4-0.30.40.40.40.4-0.40.4-0.5-0.40.4-0.4-0.3-0.30.0
Patch foraging total patch changes 0 sec0.30.40.80.60.70.70.7-0.60.80.5-0.6-0.6-0.7-0.70.7-0.60.90.7-0.60.60.70.70.0
Patch foraging total patch changes 12 sec0.00.00.0-0.1-0.10.00.00.1-0.0-0.10.20.20.10.1-0.10.1-0.0-0.00.2-0.10.10.10.0
Patch foraging total patch changes 18 sec0.70.91.41.21.11.21.1-1.01.10.7-0.8-0.9-1.0-1.00.9-0.91.01.0-0.80.90.90.90.0
Patch foraging total patch changes 24 sec0.40.40.6-0.6-0.7-0.7-0.70.7-0.6-0.80.70.70.60.6-0.60.7-0.5-0.60.7-0.7-0.7-0.60.0
Patch foraging total patch changes 6 sec0.00.10.20.30.30.20.2-0.20.30.1-0.2-0.2-0.3-0.30.2-0.20.40.3-0.20.20.20.10.0
Patch foraging time to switch 0 sec1.11.63.01.71.51.41.4-1.31.21.2-1.3-1.3-1.3-1.31.3-1.31.21.3-1.21.11.21.20.0
Patch foraging water rate 0 sec0.20.40.8-0.9-0.7-0.7-0.60.6-0.4-0.70.60.60.60.6-0.60.7-0.3-0.50.6-0.4-0.7-0.60.0
Patch foraging water rate 12 sec0.10.20.4-0.6-0.6-0.4-0.40.4-0.3-0.50.50.50.50.5-0.50.5-0.3-0.40.5-0.4-0.4-0.40.0
Patch foraging water rate 18 sec0.40.61.3-0.7-0.9-1.2-0.90.8-0.7-0.80.80.80.70.7-0.70.8-0.6-0.70.7-0.7-0.7-0.60.0
Patch foraging water rate 24 sec0.40.50.8-0.8-0.9-0.8-0.70.7-0.6-0.70.80.80.70.7-0.70.8-0.7-0.60.9-0.7-0.5-0.50.0
Patch foraging water rate 6 sec0.20.30.6-0.8-0.7-0.6-0.60.6-0.4-0.40.50.60.50.5-0.50.5-0.5-0.40.6-0.5-0.3-0.30.0
Seeking ratio, delayed vs. immediate footshock0.00.10.20.50.20.20.2-0.20.40.20.0-0.1-0.2-0.20.2-0.20.00.3-0.20.20.20.20.0
Distance traveled before self-admin1.01.01.41.11.00.91.1-1.11.21.0-0.8-1.0-1.1-1.11.0-1.11.01.2-1.01.01.01.00.0
Distance traveled after self-admin0.20.20.60.80.60.20.4-0.60.60.4-0.1-0.4-0.6-0.50.5-0.50.60.6-0.60.50.40.40.0
Extensor digitorum longus weight0.20.81.1-1.0-0.9-1.0-1.01.1-1.0-1.00.90.90.80.8-0.80.9-0.8-0.80.8-0.9-0.9-0.90.0
Bone: elastic displacement0.10.10.5-0.7-0.4-0.3-0.20.2-0.3-0.20.10.30.30.3-0.30.3-0.1-0.30.2-0.2-0.2-0.20.0
Bone: elastic work0.00.00.0-0.1-0.00.20.1-0.00.00.1-0.20.00.0-0.00.00.10.0-0.10.1-0.00.10.20.0
Bone: endosteal estimation3.57.610.93.33.13.13.0-3.02.82.9-2.8-2.8-2.7-2.82.8-2.72.72.7-2.62.62.62.60.0
Bone: endosteal perimeter1.83.85.82.42.22.12.1-2.12.12.0-1.9-2.0-2.0-2.01.9-2.01.92.0-1.91.91.81.70.0
Epididymis fat weight1.33.04.21.61.71.71.8-1.71.81.8-1.9-1.7-1.8-1.81.8-1.72.01.7-1.71.81.91.90.0
Delta time in closed arm before/after self-admin1.51.51.81.31.31.31.3-1.31.31.2-1.2-1.2-1.2-1.21.2-1.21.21.2-1.21.21.21.20.0
Delta time in open arm before/after self-admin0.80.81.0-0.8-0.8-1.0-1.01.0-1.0-0.90.80.90.90.9-0.90.9-1.0-0.90.9-1.0-0.9-0.90.0
Diff in mean of infusions in LGA sessions0.80.91.3-0.7-0.9-1.1-1.21.0-0.9-1.11.00.90.91.0-0.91.0-0.8-0.90.9-0.9-1.1-1.10.0
Delay discount exponential model param0.50.60.9-0.3-0.6-0.9-1.00.7-0.7-0.91.00.70.70.8-0.80.7-0.9-0.70.6-0.6-0.9-0.90.0
Extinction: sum of active levers before priming0.20.20.3-0.5-0.5-0.5-0.50.5-0.4-0.40.50.40.40.4-0.40.4-0.5-0.40.4-0.5-0.4-0.40.0
Active lever presses in extinction session 60.00.00.10.20.1-0.2-0.20.2-0.1-0.1-0.2-0.1-0.0-0.10.10.10.1-0.0-0.0-0.0-0.0-0.00.0
Bone: final force4.36.98.62.92.92.92.9-2.82.82.7-2.7-2.6-2.6-2.62.6-2.62.52.6-2.52.62.52.60.0
Bone: final moment3.45.57.32.52.52.72.7-2.52.52.4-2.5-2.3-2.3-2.42.4-2.32.22.3-2.22.32.32.40.0
Food consumed during 24 hour testing period0.50.62.11.41.00.70.7-0.70.70.7-0.7-0.8-0.8-0.80.8-0.70.70.8-0.70.70.80.80.0
Glucose0.00.00.3-0.6-0.30.10.00.1-0.20.0-0.10.20.20.2-0.20.2-0.1-0.20.3-0.20.10.10.0
Heart weight2.63.75.1-2.3-2.1-2.1-2.02.0-2.0-1.91.91.92.02.0-1.92.0-1.8-2.01.9-1.9-1.9-1.90.0
Delay discount hyperbolic model param0.30.30.6-0.2-0.4-0.7-0.80.5-0.5-0.70.80.50.50.6-0.60.5-0.7-0.50.4-0.4-0.7-0.70.0
Intermittent access intake day 1-15 change1.21.11.61.21.21.21.2-1.31.11.1-0.9-1.1-1.0-1.01.0-1.11.01.1-1.11.11.01.00.0
Intermittent access intake escalation1.81.82.51.41.41.51.5-1.61.41.4-1.2-1.3-1.3-1.31.3-1.41.41.3-1.41.41.31.30.0
Intermittent access intake escalation 20.00.00.1-0.4-0.1-0.00.1-0.20.10.10.1-0.1-0.00.0-0.0-0.10.10.0-0.20.2-0.0-0.00.0
Intermitt. access day 1 inactive lever presses0.00.10.2-0.3-0.3-0.1-0.10.1-0.0-0.20.40.30.20.2-0.30.2-0.3-0.10.2-0.2-0.2-0.20.0
Intermitt. access day 15 inactive lever presses1.61.72.21.21.31.31.4-1.51.51.4-1.2-1.3-1.4-1.31.3-1.41.41.4-1.41.41.31.30.0
Intermitt. access escalation Index0.40.30.5-0.3-0.6-0.5-0.60.5-0.6-0.60.70.60.60.6-0.60.6-0.6-0.50.6-0.6-0.7-0.70.0
Intermittent access day 1 total infusions0.40.51.3-1.2-0.9-0.8-0.80.9-1.0-0.60.40.60.70.7-0.70.7-0.6-0.80.7-0.6-0.5-0.50.0
Intermittent access day 15 total infusions0.10.10.20.20.30.40.3-0.30.20.4-0.4-0.3-0.3-0.30.3-0.30.40.2-0.40.40.40.40.0
Intermittent access terminal intake (last 3 days)0.20.20.30.20.40.50.5-0.50.30.6-0.6-0.5-0.4-0.40.4-0.50.50.4-0.50.60.50.50.0
Intermittent access total infusions0.10.10.3-0.5-0.4-0.3-0.30.3-0.4-0.20.10.20.30.2-0.20.2-0.2-0.30.2-0.1-0.1-0.10.0
Intermittent access day 1 locomotion0.10.10.20.20.30.30.4-0.30.30.4-0.4-0.4-0.4-0.40.4-0.40.40.4-0.40.40.50.50.0
Intermittent access day 15 total locomotion5.66.07.12.42.52.52.7-2.62.62.6-2.4-2.5-2.5-2.52.5-2.52.52.5-2.62.52.52.50.0
Intermittent access total locomotion2.12.42.81.41.61.51.6-1.61.61.7-1.5-1.6-1.6-1.61.6-1.61.61.5-1.61.61.71.70.0
Intermittent access standard deviation1.01.11.81.31.11.11.1-1.11.21.1-0.9-1.0-1.1-1.01.0-1.11.01.1-1.11.11.01.00.0
Left kidney weight3.08.310.22.83.13.03.0-3.13.12.9-2.9-2.9-2.9-2.92.9-2.93.22.9-3.03.12.72.80.0
Right kidney weight3.910.912.63.33.53.53.5-3.53.43.5-3.4-3.4-3.4-3.33.3-3.43.43.3-3.33.43.33.30.0
Cocaine induced anxiety0.00.00.10.0-0.0-0.1-0.0-0.00.1-0.10.30.10.00.1-0.10.0-0.10.00.0-0.0-0.1-0.10.0
Post-drug Anxiety0.10.10.4-0.0-0.3-0.4-0.50.4-0.4-0.40.60.40.30.4-0.40.3-0.4-0.30.3-0.4-0.5-0.50.0
Baseline Anxiety0.30.30.5-0.2-0.4-0.6-0.70.7-0.7-0.60.50.50.60.6-0.50.6-0.6-0.60.6-0.6-0.6-0.60.0
Tail length1.33.85.01.92.12.02.1-2.12.12.2-1.9-1.9-1.9-1.91.9-1.92.12.0-1.92.02.22.10.0
Length with tail2.59.210.92.93.23.13.2-3.23.33.3-3.1-3.1-3.0-3.03.1-3.03.33.0-3.13.23.13.00.0
Length without tail1.73.74.71.82.01.91.9-2.02.01.9-2.1-2.0-2.0-2.02.1-2.02.22.0-2.12.11.81.80.0
Times rat made contact with spout2.63.03.8-1.7-1.8-1.9-1.91.9-1.9-1.81.81.71.71.7-1.71.7-1.7-1.71.7-1.7-1.8-1.80.0
Lifetime Intake0.00.00.1-0.10.00.10.1-0.1-0.00.2-0.3-0.2-0.1-0.10.2-0.20.20.0-0.20.20.30.30.0
Liver weight, left5.99.411.83.43.43.43.3-3.23.23.1-3.0-3.1-3.1-3.13.1-3.13.23.1-3.03.13.03.00.0
Liver weight, right2.74.55.12.12.32.22.2-2.22.22.2-2.0-2.1-2.2-2.22.1-2.22.22.2-2.12.22.22.20.0
Locomotor activity0.10.20.50.60.60.70.6-0.50.60.3-0.3-0.4-0.5-0.40.4-0.50.30.5-0.30.40.40.40.0
Locomotor testing distance0.00.00.10.20.10.30.2-0.00.0-0.10.10.1-0.0-0.0-0.1-0.0-0.30.10.1-0.10.10.10.0
Locomotor testing rearing1.11.62.71.61.41.41.4-1.31.31.3-1.2-1.2-1.3-1.31.3-1.31.21.3-1.11.21.41.40.0
Locomotion in novel chamber0.70.91.3-1.1-1.0-0.8-0.91.0-1.0-1.00.81.00.90.9-0.91.0-0.9-0.91.1-1.0-0.9-0.90.0
Locomotion in novel chamber post-restriction1.92.23.11.61.61.51.5-1.51.51.5-1.6-1.5-1.5-1.61.6-1.51.81.5-1.51.41.41.40.0
Fecal boli incidents, locomotor time 10.00.00.00.20.1-0.0-0.00.0-0.0-0.0-0.1-0.1-0.0-0.00.10.0-0.2-0.00.0-0.0-0.00.00.0
Change in fecal boli incidents, locomotor task0.10.10.40.50.30.60.4-0.20.10.3-0.2-0.2-0.2-0.20.2-0.30.20.2-0.10.10.30.20.0
Time >=10cm from walls, locomotor time 11.91.93.92.01.61.61.4-1.51.51.3-1.2-1.4-1.4-1.41.4-1.41.41.4-1.41.31.21.10.0
Bouts of movement, locomotor time 10.10.20.3-0.1-0.3-0.4-0.40.4-0.4-0.50.50.40.40.4-0.40.4-0.4-0.30.4-0.5-0.5-0.50.0
Total resting periods, locomotor time 10.00.00.10.0-0.0-0.2-0.10.2-0.1-0.10.20.10.10.1-0.10.1-0.0-0.00.1-0.2-0.1-0.10.0
Rest time, locomotor task time 10.10.10.20.00.30.40.4-0.40.40.4-0.4-0.3-0.3-0.30.3-0.30.20.2-0.30.30.30.30.0
Distance moved, locomotor task time 10.20.20.50.70.60.40.4-0.40.30.4-0.3-0.5-0.5-0.40.4-0.50.30.5-0.50.50.40.30.0
Vertical activity count, locomotor time 10.80.82.41.51.10.90.8-0.90.80.8-0.8-1.0-1.0-0.90.9-0.90.80.9-0.90.90.80.80.0
Time >=10cm from walls, locomotor time 25.55.88.22.82.72.92.6-2.42.32.6-2.6-2.5-2.4-2.42.4-2.52.12.3-2.42.42.52.40.0
Bouts of movement, locomotor time 20.20.20.50.50.40.20.5-0.50.60.4-0.3-0.5-0.5-0.50.5-0.40.70.5-0.50.40.30.30.0
Total resting periods, locomotor time 20.00.00.1-0.0-0.1-0.3-0.00.00.1-0.10.20.10.00.0-0.00.10.20.00.1-0.2-0.2-0.20.0
Rest time, locomotor task time 20.00.00.0-0.1-0.1-0.00.10.00.20.00.10.1-0.0-0.0-0.0-0.00.00.10.1-0.2-0.00.10.0
Distance moved, locomotor task time 22.52.93.81.91.91.81.7-1.81.51.8-1.8-1.8-1.7-1.71.7-1.81.51.6-1.91.91.71.70.0
Vertical activity count, locomotor time 21.61.72.61.61.51.21.2-1.41.21.3-1.4-1.5-1.3-1.31.4-1.41.31.2-1.51.51.21.10.0
Light reinforcement 12.34.26.12.52.22.32.2-2.22.12.1-1.9-2.0-2.1-2.02.0-2.01.92.1-1.92.02.22.20.0
Light reinforcement 22.73.65.32.32.02.02.1-2.12.11.9-1.9-1.9-1.9-1.91.9-1.91.81.9-1.81.91.71.80.0
Bone: marrow area3.67.811.33.43.13.13.1-3.02.92.9-2.8-2.8-2.8-2.82.8-2.82.72.7-2.72.72.72.60.0
Bone: maximum diameter0.30.50.70.60.70.80.8-0.80.80.8-0.8-0.7-0.7-0.70.7-0.70.70.7-0.60.70.80.80.0
Bone: maximum force1.52.63.71.61.71.91.9-1.81.71.8-1.8-1.6-1.5-1.61.6-1.61.61.5-1.51.61.61.60.0
Bone: maximum moment1.01.72.71.31.41.71.6-1.41.31.4-1.5-1.3-1.2-1.31.3-1.21.21.2-1.21.31.41.40.0
Mean time between licks in bursts0.50.60.9-0.8-0.9-0.9-0.80.7-0.7-0.81.00.80.80.8-0.90.7-0.8-0.80.8-0.8-1.0-1.00.0
Mean num. licks in bursts0.20.20.4-0.4-0.4-0.6-0.50.5-0.5-0.60.40.40.40.4-0.40.5-0.4-0.50.4-0.5-0.6-0.60.0
Cd content in liver1.21.31.61.21.21.21.2-1.21.11.2-1.3-1.2-1.1-1.11.2-1.11.21.1-1.21.21.21.20.0
Co content in liver2.52.93.92.01.91.91.8-1.91.71.8-1.7-1.7-1.7-1.71.7-1.71.71.7-1.71.71.51.60.0
Cu content in liver3.54.25.0-2.2-2.2-2.1-2.22.1-2.1-2.12.02.02.12.1-2.02.1-2.1-2.12.0-2.0-2.2-2.20.0
Fe content in liver4.45.26.82.02.32.42.5-2.62.52.5-2.4-2.3-2.3-2.32.3-2.42.52.3-2.42.42.22.20.0
K content in liver1.21.21.8-1.3-1.2-1.1-1.21.0-1.1-1.11.11.11.11.1-1.11.1-0.9-1.11.0-1.0-1.3-1.40.0
Mg content in liver2.93.04.1-2.0-1.9-1.7-1.81.7-1.9-1.71.71.71.81.8-1.81.7-1.7-1.81.8-1.7-1.8-1.80.0
Mn content in liver0.10.10.4-0.2-0.3-0.2-0.30.2-0.3-0.30.30.30.30.3-0.30.3-0.3-0.30.3-0.3-0.5-0.60.0
Na content in liver0.00.00.10.1-0.0-0.2-0.2-0.10.1-0.00.30.00.00.1-0.1-0.00.10.0-0.10.1-0.3-0.20.0
Rb content in liver0.10.10.20.40.40.40.4-0.30.20.3-0.5-0.4-0.3-0.30.4-0.30.40.3-0.30.30.50.50.0
Se content in liver2.93.65.7-2.4-2.2-2.0-2.01.8-2.0-1.91.91.91.91.9-2.01.9-1.6-1.91.8-1.7-2.0-2.00.0
Sr content in liver0.00.00.00.1-0.0-0.1-0.20.2-0.2-0.10.10.10.20.1-0.10.2-0.2-0.20.1-0.2-0.1-0.10.0
Zn content in liver0.30.41.10.20.51.01.0-0.50.50.6-0.9-0.5-0.5-0.60.6-0.40.60.5-0.30.50.90.90.0
Bone: minimum diameter1.01.92.71.51.51.61.6-1.51.51.4-1.5-1.4-1.4-1.41.4-1.31.41.3-1.21.31.41.40.0
Time in familiar zone, hab. session 10.00.00.1-0.4-0.20.0-0.10.2-0.2-0.10.00.20.20.1-0.20.2-0.1-0.20.2-0.1-0.00.00.0
Time in novel zone, hab. session 10.30.30.40.60.60.70.6-0.60.50.6-0.5-0.6-0.5-0.50.5-0.60.40.5-0.50.50.50.40.0
Total zone transitions, hab. session 12.63.76.3-2.5-2.2-2.0-2.02.0-2.0-1.92.02.02.02.0-2.01.8-1.8-1.91.9-1.8-1.8-1.70.0
Total locomotion distance, hab. session 12.02.85.4-2.3-2.0-1.8-1.81.7-1.8-1.71.71.71.71.7-1.81.6-1.4-1.61.7-1.6-1.5-1.50.0
Locomotion velocity, hab. session 11.92.75.4-2.3-2.0-1.7-1.81.7-1.8-1.61.71.71.71.7-1.71.6-1.4-1.61.6-1.5-1.5-1.40.0
Time in familiar zone, hab. session 21.21.31.8-0.8-1.0-1.3-1.21.2-0.9-1.31.31.21.01.1-1.11.1-1.2-1.01.2-1.2-1.3-1.30.0
Time in novel zone, hab. session 21.41.42.11.01.11.41.3-1.31.01.4-1.4-1.3-1.1-1.21.2-1.21.21.0-1.21.31.31.30.0
Total zone transitions, hab. session 20.40.50.7-0.9-0.8-0.7-0.70.6-0.5-0.70.80.80.70.7-0.80.7-0.7-0.60.7-0.7-0.7-0.70.0
Total locomotion distance, hab. session 22.43.24.3-2.1-2.0-1.9-1.91.8-1.7-1.91.91.91.81.8-1.91.8-1.6-1.71.9-1.8-1.8-1.80.0
Locomotion velocity, hab. session 22.94.05.7-2.4-2.3-2.2-2.12.0-1.9-2.12.22.12.02.0-2.12.0-1.8-1.92.0-1.9-2.0-2.00.0
Novel to familiar place preference ratio0.20.20.4-0.00.30.50.5-0.50.40.5-0.6-0.4-0.4-0.40.4-0.40.50.4-0.40.50.50.50.0
Novelty place preference0.20.20.3-0.00.30.50.5-0.40.30.5-0.6-0.4-0.4-0.40.4-0.40.50.3-0.40.50.50.50.0
Time in novel zone, NPP test0.20.20.40.10.40.50.5-0.50.40.6-0.6-0.5-0.4-0.50.5-0.50.50.4-0.50.50.60.60.0
Total zone transitions, NPP test1.82.63.8-2.0-1.8-1.6-1.61.6-1.6-1.61.61.71.61.6-1.71.6-1.7-1.61.7-1.6-1.5-1.50.0
Total locomotion distance, NPP test1.52.02.8-1.7-1.6-1.5-1.51.5-1.5-1.51.41.51.41.4-1.41.5-1.4-1.41.5-1.4-1.3-1.30.0
Locomotion velocity, NPP test2.23.14.0-2.0-2.0-1.9-1.91.9-1.8-1.91.81.81.81.8-1.81.8-1.7-1.71.8-1.8-1.7-1.70.0
Intraocular pressure1.11.52.31.11.21.41.4-1.31.31.2-1.4-1.2-1.3-1.31.3-1.21.51.3-1.21.31.21.20.0
Delta distance traveled before/after self-admin0.40.50.7-0.5-0.6-0.8-0.80.7-0.8-0.80.70.60.70.7-0.70.7-0.6-0.70.6-0.6-0.7-0.70.0
Delta ambulatory time before/after self-admin0.50.60.8-0.5-0.7-0.9-0.90.8-0.8-0.80.90.70.70.8-0.70.8-0.7-0.80.6-0.7-0.8-0.80.0
Parametrial fat weight2.44.76.62.62.42.42.4-2.32.32.3-1.9-2.1-2.2-2.22.1-2.22.02.3-2.12.12.12.20.0
Pavlov. Cond. lever latency0.60.83.01.71.20.70.8-0.81.10.7-0.6-0.8-0.9-0.90.9-0.80.80.9-0.80.70.80.70.0
Pavlov. Cond. magazine entry latency0.81.02.5-1.6-1.2-0.9-0.91.1-1.1-0.90.71.01.01.0-1.01.0-1.0-1.01.1-0.9-0.8-0.80.0
Pavlov. Cond. change in total contacts0.40.40.80.00.40.90.7-0.70.30.8-0.8-0.6-0.6-0.60.5-0.70.60.5-0.60.70.80.90.0
Pavlov. Cond. index score0.40.62.5-1.6-1.0-0.5-0.60.7-0.9-0.60.30.70.80.7-0.70.7-0.7-0.80.8-0.6-0.5-0.50.0
Pavlov. Cond. latency score0.30.42.2-1.5-0.9-0.4-0.50.6-0.8-0.50.30.60.70.6-0.60.6-0.6-0.70.7-0.5-0.5-0.40.0
Pavlov. Cond. lever contacts0.50.62.5-1.6-1.1-0.6-0.70.8-1.0-0.60.50.70.80.8-0.80.7-0.8-0.80.7-0.6-0.7-0.60.0
Pavlov. Cond. magazine entry number1.21.52.71.61.51.21.2-1.31.31.2-1.1-1.2-1.3-1.21.3-1.31.31.3-1.31.21.01.00.0
Pavlov. Cond. intertrial magazine entries0.00.00.10.20.1-0.1-0.1-0.0-0.10.00.0-0.1-0.0-0.00.1-0.00.1-0.0-0.20.1-0.0-0.10.0
Pavlov. Cond. lever-magazine prob. diff.0.40.52.5-1.6-1.0-0.4-0.50.7-0.9-0.50.30.60.70.6-0.70.7-0.6-0.80.7-0.5-0.5-0.40.0
Pavlov. Cond. response bias1.41.74.0-2.0-1.6-1.2-1.31.3-1.5-1.21.01.31.41.3-1.31.3-1.2-1.41.3-1.2-1.1-1.10.0
Pavlov. Cond. lever latency2.23.04.02.01.91.91.8-2.01.81.8-1.6-1.8-1.7-1.71.7-1.91.71.7-1.91.81.61.50.0
Pavlov. Cond. magazine entry latency0.20.20.40.60.50.30.4-0.40.50.4-0.5-0.5-0.5-0.50.5-0.40.60.4-0.50.50.50.50.0
Pavlov. Cond. change in total contacts1.31.82.5-1.3-1.4-1.6-1.51.6-1.4-1.41.31.41.31.3-1.31.4-1.3-1.31.4-1.4-1.2-1.20.0
Pavlov. Cond. index score0.50.60.9-0.8-0.8-0.9-0.90.9-0.8-0.90.70.80.80.7-0.70.8-0.7-0.80.8-0.8-0.7-0.70.0
Pavlov. Cond. latency score0.30.30.5-0.6-0.6-0.7-0.70.7-0.6-0.60.50.60.60.6-0.50.6-0.6-0.60.6-0.6-0.5-0.50.0
Pavlov. Cond. lever contacts1.52.02.8-1.6-1.6-1.5-1.51.7-1.5-1.51.31.51.41.4-1.41.5-1.3-1.41.5-1.5-1.2-1.20.0
Pavlov. Cond. magazine entry number0.00.10.1-0.4-0.3-0.1-0.20.1-0.2-0.20.20.20.20.2-0.30.2-0.3-0.20.2-0.2-0.2-0.20.0
Pavlov. Cond. intertrial magazine entries0.40.50.8-0.4-0.6-0.8-0.80.6-0.7-0.70.90.70.70.7-0.80.6-0.9-0.70.7-0.7-0.9-0.80.0
Pavlov. Cond. lever-magazine prob. diff.0.20.30.5-0.6-0.6-0.7-0.60.7-0.6-0.60.40.50.50.5-0.50.6-0.5-0.50.6-0.6-0.5-0.40.0
Pavlov. Cond. response bias0.81.11.7-1.3-1.2-1.2-1.11.3-1.1-1.10.91.11.11.0-1.01.2-0.9-1.11.1-1.1-0.9-0.80.0
Time in closed arm before self-admin0.40.40.7-0.7-0.7-0.8-0.80.7-0.7-0.80.70.60.70.7-0.60.7-0.4-0.70.6-0.6-0.7-0.70.0
Time in closed arm after self-admin0.00.00.20.10.10.30.1-0.20.10.1-0.3-0.2-0.1-0.20.2-0.10.50.1-0.20.30.10.10.0
Time in open arm before self-admin0.20.20.6-0.7-0.5-0.4-0.30.4-0.4-0.30.50.40.40.5-0.50.4-0.6-0.40.4-0.4-0.3-0.30.0
Time in open arm after self-admin1.71.92.8-1.5-1.4-1.7-1.41.5-1.4-1.31.41.31.41.4-1.31.3-1.6-1.41.3-1.4-1.3-1.30.0
Bone: periosteal estimation2.14.25.62.32.22.42.3-2.22.12.2-2.2-2.0-2.0-2.12.1-2.02.02.0-1.92.02.12.10.0
Bone: periosteal perimeter0.71.21.81.31.21.21.2-1.21.21.1-1.1-1.1-1.1-1.11.1-1.11.01.1-1.01.01.11.10.0
Bone: post-yield work0.20.30.40.50.50.60.6-0.60.50.6-0.6-0.6-0.5-0.50.5-0.50.50.4-0.60.50.50.50.0
Progressive ratio test 1 active lever presses0.00.00.1-0.2-0.2-0.2-0.30.4-0.3-0.20.10.20.20.2-0.20.2-0.2-0.20.2-0.2-0.1-0.10.0
Progressive ratio test 1 breakpoint0.10.10.2-0.3-0.3-0.3-0.30.4-0.4-0.30.10.20.30.2-0.20.3-0.2-0.30.3-0.3-0.1-0.10.0
Progressive ratio test 1 inactive lever presses0.91.01.71.21.11.31.1-1.01.01.0-0.9-1.0-1.0-1.01.0-1.01.01.0-1.01.01.11.10.0
Progressive ratio test 2 active lever presses0.00.00.10.20.10.20.0-0.0-0.00.1-0.0-0.0-0.0-0.00.0-0.00.10.0-0.00.10.00.00.0
Progressive ratio test 2 breakpoint0.00.00.00.20.00.1-0.10.1-0.1-0.00.10.10.10.1-0.10.1-0.1-0.10.1-0.0-0.0-0.00.0
Progressive ratio test 2 inactive lever presses0.10.10.3-0.5-0.4-0.3-0.30.2-0.3-0.30.40.30.30.3-0.30.2-0.2-0.30.1-0.2-0.3-0.30.0
Incentive Sensitization - Responses0.60.61.1-0.5-0.8-0.7-0.80.7-0.8-0.81.00.90.80.8-0.90.8-0.8-0.70.8-0.8-0.9-0.90.0
Incentive Sensitization - Breakpoint0.20.30.6-0.2-0.4-0.4-0.50.4-0.5-0.50.70.60.50.5-0.60.5-0.6-0.40.5-0.5-0.6-0.60.0
Sum of active levers in priming session hrs 5-60.50.51.0-1.0-0.8-0.7-0.70.7-0.8-0.60.60.60.70.7-0.70.7-0.6-0.80.6-0.6-0.6-0.60.0
Progressive ratio4.04.67.12.72.52.22.2-2.32.32.0-2.0-2.2-2.2-2.22.2-2.22.22.3-2.22.11.91.90.0
Food seeking constrained by brief footshock0.10.10.3-0.3-0.3-0.5-0.50.4-0.3-0.50.30.30.30.3-0.20.4-0.3-0.30.3-0.3-0.5-0.50.0
Seeking ratio, punishment vs. effort2.83.45.1-2.3-2.1-1.9-1.91.9-1.9-1.81.71.91.91.9-1.91.9-1.9-1.91.9-1.8-1.7-1.70.0
Retroperitoneal fat weight1.24.04.82.02.12.02.2-2.12.12.0-2.1-2.0-2.1-2.12.1-2.02.22.0-2.02.02.12.10.0
Reaction time number correct0.71.01.41.21.11.01.0-1.01.21.0-0.9-1.0-1.1-1.11.0-1.00.91.1-1.00.91.01.00.0
Reaction time mean minus median0.20.30.40.50.60.50.5-0.60.50.6-0.5-0.6-0.5-0.50.5-0.60.50.5-0.60.60.50.50.0
Reaction time mean minus median AUC0.10.20.30.30.40.40.4-0.40.30.5-0.6-0.5-0.4-0.40.4-0.40.40.4-0.50.40.50.50.0
Reaction time num false alarms0.00.00.2-0.0-0.1-0.1-0.20.1-0.1-0.30.50.30.20.2-0.30.2-0.2-0.10.2-0.2-0.3-0.30.0
Reaction time num false alarms AUC0.40.61.1-0.6-0.7-0.7-0.80.7-0.6-0.91.10.90.80.8-0.90.8-0.8-0.70.8-0.7-0.8-0.80.0
Reaction time trials correct on left0.71.01.41.21.11.01.0-1.01.21.0-0.9-1.0-1.1-1.11.0-1.00.91.1-1.00.91.01.00.0
Reaction time trials on left0.71.01.41.21.11.01.0-0.91.11.0-0.9-1.0-1.1-1.01.0-1.00.91.1-1.00.91.01.00.0
Reaction time mean0.10.20.40.40.50.50.5-0.40.40.5-0.6-0.6-0.4-0.50.5-0.50.20.4-0.50.40.40.40.0
Reaction time mean AUC0.40.60.90.80.80.90.9-0.80.70.8-1.0-0.9-0.8-0.80.8-0.80.50.7-0.80.80.80.80.0
Median of all reaction times0.20.20.40.50.50.60.6-0.40.40.5-0.6-0.6-0.5-0.50.5-0.50.20.4-0.50.40.40.40.0
Reaction time omissions0.10.10.30.60.40.20.2-0.30.40.2-0.1-0.3-0.3-0.20.2-0.30.20.3-0.40.30.10.10.0
Reaction time false alarm rate1.21.72.2-1.4-1.4-1.2-1.31.2-1.3-1.41.51.41.31.4-1.41.3-1.3-1.31.3-1.2-1.4-1.40.0
Reaction time premature initiation rate0.10.20.3-0.4-0.4-0.4-0.40.4-0.5-0.50.50.30.40.4-0.40.3-0.6-0.40.3-0.3-0.5-0.50.0
Reaction time premature initiations0.10.10.20.50.40.30.3-0.30.30.2-0.2-0.4-0.4-0.30.3-0.40.10.4-0.40.40.20.20.0
Std. dev. reaction times0.00.00.10.20.20.10.1-0.20.20.2-0.2-0.3-0.2-0.20.2-0.20.20.2-0.30.20.10.10.0
Reaction time trials completed0.71.01.41.21.11.01.0-0.91.11.0-0.9-1.0-1.1-1.01.0-1.00.91.1-1.00.91.01.00.0
Reaction time trials AUC0.71.01.51.21.11.01.0-1.01.11.0-0.9-1.0-1.1-1.01.0-1.00.91.1-1.00.91.01.00.0
Run reversals in cocaine runway, females0.10.10.30.40.40.40.4-0.20.10.4-0.6-0.3-0.3-0.30.3-0.30.20.2-0.20.20.40.60.0
Run reversals in cocaine runway, males0.30.30.6-0.20.30.50.7-0.60.60.8-0.4-0.5-0.5-0.50.5-0.60.30.5-0.70.60.70.60.0
Latency to leave start box in cocaine runway0.50.60.8-0.6-0.8-0.6-0.90.8-0.8-0.80.80.80.80.8-0.80.8-0.8-0.80.8-0.8-0.8-0.70.0
Latency to leave start box in cocaine runway, F0.60.71.0-0.8-0.9-0.9-1.00.9-0.8-0.90.80.80.80.8-0.80.9-0.8-0.80.8-0.8-0.9-0.80.0
Latency to leave start box in cocaine runway, M0.00.00.10.20.10.30.1-0.1-0.00.10.10.10.10.1-0.10.0-0.1-0.10.0-0.10.0-0.00.0
Std. dev. time between licks in bursts0.00.00.2-0.20.00.40.4-0.30.30.2-0.3-0.1-0.2-0.20.1-0.20.00.20.00.20.20.20.0
Total sessions with >9 infusions0.00.00.0-0.1-0.10.00.00.1-0.10.0-0.2-0.00.0-0.00.00.0-0.1-0.10.1-0.00.10.10.0
Short access day 1 total inactive lever presses0.10.10.4-0.6-0.4-0.3-0.20.2-0.3-0.20.20.20.30.3-0.20.2-0.0-0.30.1-0.1-0.3-0.30.0
Short access day 10 total inactive lever presses0.10.10.30.50.40.50.4-0.40.50.20.1-0.1-0.3-0.20.2-0.30.20.4-0.20.20.20.20.0
Short access day 1 total infusions1.21.32.4-1.6-1.3-1.2-1.21.2-1.3-1.10.91.11.11.1-1.11.1-1.1-1.21.1-1.0-1.0-1.00.0
Short access day 10 total infusions0.00.00.0-0.1-0.1-0.2-0.10.1-0.1-0.10.10.00.10.1-0.00.0-0.1-0.10.0-0.0-0.0-0.00.0
Short access total infusions0.00.00.1-0.4-0.2-0.1-0.10.2-0.2-0.0-0.10.00.10.1-0.00.0-0.0-0.10.00.00.10.10.0
Short access day 1 locomotion0.10.10.2-0.3-0.4-0.2-0.30.4-0.3-0.30.30.40.30.3-0.40.4-0.4-0.30.5-0.4-0.2-0.20.0
Short access day 10 total locomotion0.40.51.0-0.8-0.8-1.0-0.70.7-0.5-0.70.90.80.60.7-0.70.7-0.6-0.50.7-0.7-0.6-0.60.0
Short access total locomotion0.00.00.00.1-0.0-0.1-0.00.00.10.00.1-0.0-0.1-0.10.1-0.00.10.1-0.00.00.10.10.0
One hour access (0.3 mA shock)0.80.91.3-1.1-1.1-1.1-1.11.0-1.0-1.01.01.01.01.0-1.01.0-0.9-1.00.9-0.9-1.0-1.00.0
Compulsive drug intake3.13.14.3-1.9-1.8-2.1-2.01.9-1.8-1.91.81.71.81.8-1.71.8-1.6-1.81.7-1.7-1.8-1.80.0
One hour access (shock baseline)0.30.30.40.30.40.40.6-0.60.50.6-0.6-0.6-0.5-0.60.6-0.60.60.5-0.60.60.60.60.0
Social response proportion0.00.00.0-0.1-0.1-0.1-0.00.1-0.0-0.0-0.00.10.10.0-0.00.1-0.1-0.10.1-0.1-0.0-0.00.0
Social responses0.10.10.2-0.1-0.3-0.2-0.30.3-0.2-0.30.40.40.20.3-0.30.3-0.4-0.20.4-0.4-0.2-0.20.0
Social time0.10.10.3-0.1-0.3-0.3-0.30.3-0.3-0.30.60.40.30.4-0.40.3-0.4-0.30.4-0.4-0.2-0.30.0
Soleus weight0.20.60.80.70.80.90.9-0.80.70.8-0.8-0.8-0.8-0.80.8-0.80.70.8-0.80.80.80.90.0
Bone: stiffness1.22.02.81.51.51.71.6-1.51.41.5-1.5-1.4-1.4-1.41.4-1.41.31.3-1.31.31.41.40.0
Tibialis anterior weight0.93.13.9-1.8-1.8-2.0-1.92.0-1.9-2.01.81.81.71.7-1.71.8-1.8-1.71.8-1.8-1.7-1.70.0
Time to tail flick, vehicle, before self-admin2.72.83.91.71.72.01.9-1.91.81.7-1.4-1.6-1.7-1.71.6-1.71.51.8-1.61.71.61.60.0
Time to tail flick, vehicle, after self-admin0.10.10.2-0.0-0.3-0.4-0.40.3-0.3-0.40.40.40.30.3-0.30.4-0.3-0.30.4-0.4-0.4-0.40.0
Time to tail flick, test, before self-admin0.00.00.20.1-0.1-0.0-0.20.00.1-0.30.40.30.10.1-0.20.20.0-0.00.2-0.1-0.3-0.30.0
Time to tail flick, test, after self-admin0.00.00.20.10.10.50.2-0.20.20.2-0.1-0.1-0.1-0.10.1-0.10.20.1-0.10.10.10.10.0
Delta time to tail flick, vehicle, before/after SA1.71.72.3-1.1-1.2-1.5-1.51.5-1.4-1.41.01.31.31.3-1.21.4-1.3-1.41.3-1.4-1.3-1.30.0
Delta time to tail flick, test, before/after SA1.51.42.41.31.31.61.3-1.21.01.3-1.3-1.2-1.1-1.11.2-1.20.91.1-1.11.11.21.20.0
Tibia length3.08.410.53.23.23.03.0-3.23.13.1-2.8-3.0-2.9-2.92.9-3.02.92.9-3.03.02.82.70.0
Ambulatory time before self-admin0.50.50.70.60.70.50.7-0.80.80.7-0.5-0.7-0.8-0.70.7-0.70.80.8-0.70.70.70.70.0
Ambulatory time after self-admin0.00.00.30.0-0.1-0.6-0.30.1-0.0-0.30.50.10.00.1-0.10.10.10.0-0.0-0.1-0.2-0.20.0
Bone: tissue strength0.00.00.00.10.0-0.0-0.00.10.0-0.1-0.00.00.00.00.00.1-0.1-0.10.0-0.10.00.00.0
Total heroin consumption0.30.31.0-0.6-0.6-1.0-0.70.5-0.6-0.60.80.50.50.6-0.50.5-0.4-0.50.4-0.4-0.6-0.60.0
Bone: trabecular number1.01.51.9-1.3-1.3-1.4-1.41.3-1.3-1.21.21.21.31.3-1.21.2-1.1-1.31.2-1.2-1.2-1.20.0
Bone: trabecular spacing1.92.53.01.71.71.71.7-1.61.61.5-1.6-1.6-1.6-1.61.6-1.61.51.6-1.51.51.61.50.0
Bone: trabecular thickness0.30.40.60.50.60.70.7-0.60.60.7-0.8-0.7-0.6-0.60.7-0.60.70.6-0.70.70.70.70.0
Bone: trabecular tissue density0.00.10.1-0.10.10.10.2-0.30.30.3-0.3-0.2-0.2-0.20.3-0.20.30.2-0.30.30.20.20.0
Water consumed over 24 hours1.31.62.1-1.0-1.2-1.4-1.41.4-1.4-1.31.31.31.31.3-1.21.3-1.3-1.31.3-1.3-1.2-1.20.0
Number of responses in last shaping day1.41.54.0-2.0-1.6-1.2-1.21.3-1.4-1.00.91.21.31.3-1.21.2-1.0-1.41.1-1.1-1.0-1.00.0