Hub : Genes

Pnliprp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Pnliprp2 0.1 0.05 9.7e-10 0.12 0.13 0.13 0.13 1.2e-09 8.4e-11 2.4e-10 1.2e-10
2 Brain gene expression Pnliprp2 0.1 0.05 6.4e-08 0.09 0.09 0.09 0.09 8.0e-09 1.2e-08 1.6e-08 1.5e-08
3 BLA gene expression Pnliprp2 0.2 0.13 1.5e-07 0.09 0.12 0.1 0.12 1.7e-05 5.9e-07 7.4e-06 4.3e-07
4 NAcc gene expression Pnliprp2 0.03 0.02 3.7e-05 0.01 0.03 0.02 0.02 1.8e-03 7.5e-05 8.1e-04 9.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density2.44.45.02.2-1.92.22.0
Area under the delay curve0.10.20.30.4-0.4-0.3-0.5
BMI with tail2.37.913.43.7-3.32.31.3
BMI without tail0.63.46.12.5-2.11.50.8
Body weight3.716.324.85.0-4.53.62.6
Weight adjusted by age0.10.20.30.6-0.3-0.0-0.5
Bone surface1.42.73.41.6-1.51.81.6
Bone volume1.42.83.51.9-1.81.71.2
Breakpoint value in progressive ratio session0.91.72.71.7-1.51.00.8
Number of licking bursts0.72.12.91.2-1.01.71.7
Context. condit. distance diff. score0.30.41.0-0.71.0-0.20.1
Locomotion velocity, session 10.10.10.2-0.30.50.0-0.1
Locomotion distance, session 11.11.52.2-1.41.5-1.0-0.9
Locomotion velocity, session 21.92.33.3-1.81.8-1.3-1.0
Locomotion distance, session 20.81.11.5-1.21.2-0.8-0.8
Locomotion velocity, session 30.70.81.2-1.10.9-0.8-0.6
Locomotion distance, session 31.92.23.0-1.71.7-1.3-1.1
Stereotopy head waving bouts, day 30.20.20.3-0.40.2-0.5-0.5
Stereotopy head waving duration, day 30.00.00.10.2-0.20.10.1
Locomotion velocity, session 70.00.00.1-0.20.30.0-0.1
Locomotion distance, session 70.40.60.8-0.90.9-0.6-0.6
Stereotopy head waving bouts, day 70.00.00.10.2-0.40.0-0.0
Stereotopy head waving duration, day 70.40.51.10.9-1.10.40.2
Locomotion velocity, session 80.40.40.8-0.40.80.40.9
Locomotion distance, session 81.01.43.3-1.51.8-0.30.3
Degree of sensitization distance0.90.91.21.1-1.00.90.8
Degree of sensitization stereotypy0.60.60.90.9-0.90.70.5
Conditioned locomotion0.00.00.10.1-0.2-0.1-0.3
Cocaine response after cond. corrected4.56.78.3-2.92.8-2.5-2.1
Cocaine response after cond. not corrected3.44.96.3-2.52.5-2.1-1.7
Cocaine response before conditioning1.31.51.81.2-1.21.21.3
Saline control response0.70.91.1-1.01.1-0.9-0.9
Bone: connectivity density1.52.43.21.5-1.21.81.7
Bone: cortical apparent density3.65.77.2-2.72.7-2.1-2.0
Bone: cortical area2.33.84.82.2-2.02.11.4
Bone: cortical porosity0.40.50.60.7-0.80.60.6
Bone: cortical porosity1.61.82.21.4-1.51.21.2
Bone: cortical thickness0.40.61.10.8-0.71.10.7
Bone: cortical thickness0.10.10.2-0.10.2-0.2-0.5
Bone: cortical tissue density3.55.67.2-2.72.7-2.1-1.9
Condit. Reinf. active minus inactive responses0.20.20.6-0.20.30.40.8
Condit. Reinf. active-inactive response ratio0.10.20.50.00.00.40.7
Condit. Reinf. active responses0.60.81.70.4-0.31.11.3
Condit. Reinf. inactive responses0.91.21.80.8-0.71.31.3
Incentive salience index mean0.20.20.4-0.70.60.10.5
Condit. Reinf. lever presses0.10.20.5-0.70.5-0.30.0
Condit. Reinf. active minus inactive responses1.72.63.41.8-1.61.71.3
Condit. Reinf. active-inactive response ratio0.61.01.51.2-1.01.10.7
Condit. Reinf. active responses2.84.05.22.3-2.02.01.6
Condit. Reinf. inactive responses1.01.51.91.3-1.41.11.0
Condit. Reinf. lever presses0.81.11.61.3-1.01.10.8
Condit. Reinf. lever reinforcers received2.33.23.92.0-1.71.91.6
Conditioned reinforcement - actives0.62.22.7-1.61.6-1.4-1.3
Conditioned reinforcement - inactives0.10.20.40.6-0.50.40.3
Conditioned locomotion2.33.44.4-2.02.1-1.6-1.5
Patch foraging indifference point 0 sec0.20.61.01.0-0.80.70.4
Patch foraging indifference point AUC0.30.71.21.1-0.90.70.4
Delay disc. indifference point, 0s delay0.40.50.7-0.50.6-0.8-0.8
Delay disc. indifference point, 16s delay0.10.10.20.3-0.4-0.2-0.3
Delay disc. indifference point, 2s delay1.41.52.3-0.90.8-1.5-1.5
Delay disc. indifference point, 24s delay0.40.61.00.9-1.00.60.4
Delay disc. indifference point, 4s delay0.20.20.30.1-0.1-0.5-0.6
Delay disc. indifference point, 8s delay0.10.20.50.6-0.3-0.1-0.7
Indifference point function ln k0.10.20.4-0.60.6-0.2-0.0
Indifference point function log k0.10.20.4-0.60.6-0.2-0.0
Patch foraging total patch changes 0 sec0.30.91.51.2-1.00.90.6
Patch foraging total patch changes 12 sec1.01.31.91.4-1.21.10.8
Patch foraging total patch changes 18 sec1.22.84.22.1-1.91.60.9
Patch foraging total patch changes 24 sec0.51.82.91.7-1.51.10.8
Patch foraging total patch changes 6 sec1.22.13.21.8-1.51.41.0
Patch foraging time to switch 0 sec0.10.50.7-0.80.4-0.8-0.7
Patch foraging water rate 0 sec0.10.40.60.8-0.50.70.6
Patch foraging water rate 12 sec0.62.32.81.6-1.61.71.2
Patch foraging water rate 18 sec0.10.30.3-0.50.6-0.5-0.6
Patch foraging water rate 24 sec0.20.30.7-0.30.5-0.4-0.8
Patch foraging water rate 6 sec0.00.10.20.00.2-0.2-0.4
Seeking ratio, delayed vs. immediate footshock1.01.42.4-1.41.5-1.0-0.4
Distance traveled before self-admin3.27.07.8-2.82.6-2.6-2.5
Distance traveled after self-admin2.44.14.5-2.02.1-2.1-1.9
Extensor digitorum longus weight0.52.14.01.8-2.01.00.6
Bone: elastic displacement0.40.51.0-0.50.2-0.9-1.0
Bone: elastic work1.21.62.4-1.10.9-1.4-1.6
Bone: endosteal estimation0.51.22.01.4-1.20.90.7
Bone: endosteal perimeter0.51.22.31.5-1.40.70.0
Epididymis fat weight5.930.040.06.3-6.35.13.8
Delta time in closed arm before/after self-admin0.90.81.2-1.11.0-0.9-0.6
Delta time in open arm before/after self-admin3.94.65.52.3-2.12.21.8
Diff in mean of infusions in LGA sessions0.40.60.90.9-0.90.60.8
Delay discount exponential model param0.10.20.4-0.40.40.30.6
Extinction: sum of active levers before priming0.40.71.11.1-1.00.50.5
Active lever presses in extinction session 60.10.10.40.5-0.60.00.1
Bone: final force0.61.01.31.1-0.91.10.8
Bone: final moment0.71.11.51.2-1.01.10.8
Food consumed during 24 hour testing period0.10.10.2-0.40.40.10.4
Glucose0.91.42.41.5-1.50.80.4
Heart weight1.83.03.41.8-1.71.81.5
Delay discount hyperbolic model param0.20.20.5-0.30.30.50.7
Intermittent access intake day 1-15 change0.20.81.9-0.50.2-1.1-1.4
Intermittent access intake escalation0.10.41.1-0.3-0.1-0.8-1.0
Intermittent access intake escalation 20.20.40.7-0.50.3-0.7-0.8
Intermitt. access day 1 inactive lever presses0.34.26.02.4-2.31.91.5
Intermitt. access day 15 inactive lever presses0.20.91.61.0-1.30.80.4
Intermitt. access escalation Index0.00.00.00.00.10.10.2
Intermittent access day 1 total infusions0.10.20.4-0.30.1-0.4-0.7
Intermittent access day 15 total infusions0.20.61.5-0.40.0-0.9-1.2
Intermittent access terminal intake (last 3 days)0.20.40.9-0.2-0.1-0.7-0.9
Intermittent access total infusions0.20.30.7-0.2-0.0-0.5-0.9
Intermittent access day 1 locomotion1.52.74.2-1.41.2-1.8-2.0
Intermittent access day 15 total locomotion0.10.40.70.7-0.9-0.2-0.6
Intermittent access total locomotion1.82.23.8-1.20.8-1.7-2.0
Intermittent access standard deviation0.10.40.70.8-0.8-0.1-0.5
Left kidney weight0.00.20.40.6-0.20.50.2
Right kidney weight0.00.10.30.30.20.2-0.6
Cocaine induced anxiety0.71.93.3-1.81.6-1.2-0.6
Post-drug Anxiety0.20.20.60.1-0.00.60.8
Baseline Anxiety2.94.85.82.4-2.42.21.7
Tail length0.10.60.90.9-0.90.60.5
Length with tail0.93.84.92.2-2.01.91.7
Length without tail1.68.610.63.3-3.12.82.5
Times rat made contact with spout0.00.00.0-0.1-0.0-0.00.0
Lifetime Intake0.20.30.7-0.40.2-0.6-0.8
Liver weight, left1.42.54.02.0-1.91.30.8
Liver weight, right0.10.10.40.1-0.1-0.4-0.6
Locomotor activity0.10.20.3-0.20.2-0.6-0.6
Locomotor testing distance0.92.12.5-1.41.4-1.5-1.6
Locomotor testing rearing0.41.62.8-1.01.0-1.3-1.7
Locomotion in novel chamber1.41.92.7-1.61.6-1.3-0.9
Locomotion in novel chamber post-restriction0.82.43.4-1.91.6-1.6-1.2
Fecal boli incidents, locomotor time 10.00.10.10.3-0.10.40.0
Change in fecal boli incidents, locomotor task0.30.30.80.0-0.10.60.9
Time >=10cm from walls, locomotor time 10.10.20.5-0.10.10.30.7
Bouts of movement, locomotor time 10.70.91.51.2-1.20.70.2
Total resting periods, locomotor time 10.30.30.60.8-0.70.4-0.0
Rest time, locomotor task time 10.30.50.8-0.80.9-0.5-0.7
Distance moved, locomotor task time 10.00.10.10.1-0.2-0.4-0.2
Vertical activity count, locomotor time 10.00.20.5-0.50.3-0.7-0.3
Time >=10cm from walls, locomotor time 20.10.20.60.00.00.50.7
Bouts of movement, locomotor time 20.10.20.4-0.40.2-0.5-0.6
Total resting periods, locomotor time 20.10.30.7-0.30.2-0.7-0.8
Rest time, locomotor task time 20.30.51.0-0.50.5-0.7-1.0
Distance moved, locomotor task time 20.00.00.10.00.00.20.3
Vertical activity count, locomotor time 20.00.10.2-0.00.00.20.4
Light reinforcement 10.10.41.0-1.00.5-0.5-0.4
Light reinforcement 20.30.71.6-1.31.0-0.6-0.3
Bone: marrow area0.51.32.01.4-1.21.00.8
Bone: maximum diameter2.55.17.52.7-2.62.11.3
Bone: maximum force0.40.91.21.0-0.71.10.9
Bone: maximum moment0.61.11.41.1-0.81.21.0
Mean time between licks in bursts0.31.82.51.3-1.21.41.6
Mean num. licks in bursts1.02.83.8-1.51.2-1.9-1.9
Cd content in liver3.23.65.4-2.22.3-1.7-1.1
Co content in liver1.21.42.3-1.41.5-0.9-0.8
Cu content in liver0.60.71.2-0.91.1-0.7-0.7
Fe content in liver2.93.63.91.9-1.71.92.0
K content in liver0.20.20.4-0.20.2-0.4-0.6
Mg content in liver0.91.02.1-0.60.6-1.1-1.5
Mn content in liver0.20.20.3-0.20.4-0.4-0.6
Na content in liver0.30.30.7-0.1-0.1-0.7-0.8
Rb content in liver0.00.10.10.3-0.40.10.0
Se content in liver0.10.10.20.00.30.20.5
Sr content in liver2.82.43.1-1.61.6-1.8-1.2
Zn content in liver3.44.05.1-1.91.8-2.3-2.0
Bone: minimum diameter1.32.53.51.9-1.71.61.1
Time in familiar zone, hab. session 10.50.60.9-0.60.5-0.9-0.9
Time in novel zone, hab. session 11.61.82.21.3-1.21.51.3
Total zone transitions, hab. session 10.20.30.7-0.40.3-0.4-0.8
Total locomotion distance, hab. session 10.60.81.50.6-0.41.11.2
Locomotion velocity, hab. session 10.40.51.10.3-0.20.91.1
Time in familiar zone, hab. session 21.92.22.41.6-1.51.41.3
Time in novel zone, hab. session 21.51.61.8-1.31.3-1.3-1.2
Total zone transitions, hab. session 20.30.41.0-0.40.3-0.7-1.0
Total locomotion distance, hab. session 20.00.00.10.10.00.20.2
Locomotion velocity, hab. session 20.00.00.00.10.00.00.0
Novel to familiar place preference ratio1.21.52.31.0-0.81.51.5
Novelty place preference0.91.21.70.9-0.71.31.3
Time in novel zone, NPP test1.92.33.11.4-1.21.81.6
Total zone transitions, NPP test0.10.10.2-0.30.2-0.3-0.4
Total locomotion distance, NPP test0.10.20.4-0.10.30.40.6
Locomotion velocity, NPP test0.20.30.7-0.70.9-0.00.3
Intraocular pressure1.62.63.61.9-1.71.61.3
Delta distance traveled before/after self-admin0.10.10.10.2-0.1-0.3-0.3
Delta ambulatory time before/after self-admin0.10.20.40.6-0.50.10.1
Parametrial fat weight7.918.726.15.0-5.14.12.5
Pavlov. Cond. lever latency0.30.30.60.8-0.50.50.4
Pavlov. Cond. magazine entry latency0.00.00.0-0.1-0.2-0.00.0
Pavlov. Cond. change in total contacts0.00.00.1-0.20.0-0.1-0.2
Pavlov. Cond. index score0.00.00.0-0.2-0.1-0.2-0.2
Pavlov. Cond. latency score0.00.10.1-0.30.0-0.2-0.3
Pavlov. Cond. lever contacts0.10.10.1-0.30.1-0.3-0.3
Pavlov. Cond. magazine entry number0.00.00.10.00.20.20.3
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.20.30.20.6
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.1-0.2-0.1-0.1
Pavlov. Cond. response bias0.10.10.2-0.40.1-0.4-0.4
Pavlov. Cond. lever latency1.52.12.5-1.61.3-1.6-1.3
Pavlov. Cond. magazine entry latency0.60.91.31.1-1.10.80.5
Pavlov. Cond. change in total contacts0.61.31.81.4-1.11.20.9
Pavlov. Cond. index score1.11.72.31.5-1.31.41.0
Pavlov. Cond. latency score1.01.52.11.4-1.31.30.9
Pavlov. Cond. lever contacts0.71.11.41.2-0.91.20.9
Pavlov. Cond. magazine entry number0.50.71.0-1.00.9-0.8-0.5
Pavlov. Cond. intertrial magazine entries0.00.00.00.1-0.10.10.0
Pavlov. Cond. lever-magazine prob. diff.0.81.21.71.3-1.11.20.8
Pavlov. Cond. response bias1.72.32.81.7-1.41.71.4
Time in closed arm before self-admin0.20.30.5-0.40.5-0.6-0.7
Time in closed arm after self-admin2.52.83.4-1.71.6-1.8-1.5
Time in open arm before self-admin0.10.20.3-0.60.4-0.20.4
Time in open arm after self-admin2.42.63.21.6-1.51.81.6
Bone: periosteal estimation1.12.73.92.0-1.71.61.2
Bone: periosteal perimeter1.52.94.92.2-2.11.40.4
Bone: post-yield work1.52.64.11.2-1.11.92.0
Progressive ratio test 1 active lever presses0.71.22.0-0.80.8-1.2-1.4
Progressive ratio test 1 breakpoint0.71.22.0-0.80.8-1.2-1.4
Progressive ratio test 1 inactive lever presses0.00.10.30.5-0.30.10.1
Progressive ratio test 2 active lever presses0.20.30.9-0.00.0-0.6-1.0
Progressive ratio test 2 breakpoint0.20.30.80.1-0.1-0.5-0.9
Progressive ratio test 2 inactive lever presses0.10.50.60.8-0.70.70.5
Incentive Sensitization - Responses0.10.20.40.6-0.5-0.0-0.3
Incentive Sensitization - Breakpoint0.10.30.60.8-0.60.1-0.2
Sum of active levers in priming session hrs 5-60.70.60.91.0-1.00.60.5
Progressive ratio0.00.10.3-0.40.5-0.10.3
Food seeking constrained by brief footshock0.00.00.2-0.20.4-0.10.1
Seeking ratio, punishment vs. effort0.20.51.1-0.40.4-0.7-1.0
Retroperitoneal fat weight8.036.048.87.0-6.85.84.1
Reaction time number correct0.10.30.60.6-0.80.0-0.5
Reaction time mean minus median0.00.20.50.4-0.5-0.2-0.7
Reaction time mean minus median AUC0.21.43.7-0.50.3-1.3-1.9
Reaction time num false alarms0.20.30.6-0.70.8-0.4-0.2
Reaction time num false alarms AUC0.30.60.9-0.91.0-0.7-0.6
Reaction time trials correct on left0.10.30.60.6-0.80.0-0.5
Reaction time trials on left0.10.40.70.7-0.80.0-0.5
Reaction time mean0.51.12.6-0.40.1-1.2-1.6
Reaction time mean AUC0.61.43.2-0.50.2-1.4-1.8
Median of all reaction times1.11.73.4-0.80.5-1.6-1.8
Reaction time omissions0.71.12.41.3-1.50.4-0.0
Reaction time false alarm rate0.30.51.0-0.91.0-0.30.1
Reaction time premature initiation rate0.40.60.9-0.80.9-0.5-0.7
Reaction time premature initiations0.10.40.9-0.40.5-0.5-1.0
Std. dev. reaction times0.10.40.80.6-0.7-0.2-0.9
Reaction time trials completed0.10.40.70.7-0.80.0-0.5
Reaction time trials AUC0.10.30.60.7-0.80.0-0.5
Run reversals in cocaine runway, females0.10.10.20.5-0.10.00.1
Run reversals in cocaine runway, males0.90.91.3-1.20.7-1.0-1.0
Latency to leave start box in cocaine runway0.10.10.30.10.1-0.3-0.6
Latency to leave start box in cocaine runway, F0.00.00.10.4-0.20.1-0.0
Latency to leave start box in cocaine runway, M0.50.51.0-0.30.6-0.8-1.0
Std. dev. time between licks in bursts0.40.82.00.4-0.21.11.4
Total sessions with >9 infusions0.40.50.7-0.60.7-0.7-0.8
Short access day 1 total inactive lever presses0.40.71.70.6-0.10.91.3
Short access day 10 total inactive lever presses0.00.10.20.4-0.20.1-0.0
Short access day 1 total infusions0.20.40.6-0.60.6-0.7-0.7
Short access day 10 total infusions1.52.42.8-1.61.7-1.5-1.5
Short access total infusions0.71.01.2-1.11.0-0.9-1.0
Short access day 1 locomotion0.40.61.0-0.40.6-1.0-1.0
Short access day 10 total locomotion0.51.93.4-1.11.0-1.5-1.8
Short access total locomotion2.53.84.9-1.71.8-2.0-2.2
One hour access (0.3 mA shock)0.80.91.61.2-1.30.70.5
Compulsive drug intake0.91.31.51.2-1.21.01.1
One hour access (shock baseline)0.10.20.5-0.30.3-0.5-0.7
Social response proportion0.81.11.3-0.90.9-1.2-1.2
Social responses0.50.61.01.0-1.00.60.2
Social time0.91.42.9-0.70.5-1.4-1.7
Soleus weight0.82.46.3-0.2-0.0-1.8-2.5
Bone: stiffness0.61.11.61.0-0.81.31.1
Tibialis anterior weight0.31.02.41.3-1.60.3-0.1
Time to tail flick, vehicle, before self-admin0.30.30.60.4-0.30.70.7
Time to tail flick, vehicle, after self-admin0.00.10.10.3-0.30.20.3
Time to tail flick, test, before self-admin4.24.85.4-2.22.3-2.1-2.2
Time to tail flick, test, after self-admin0.91.01.21.0-0.91.10.9
Delta time to tail flick, vehicle, before/after SA0.40.50.90.9-0.90.30.3
Delta time to tail flick, test, before/after SA1.92.32.71.5-1.51.61.5
Tibia length0.00.00.0-0.00.10.0-0.2
Ambulatory time before self-admin1.44.45.1-2.32.1-2.0-2.0
Ambulatory time after self-admin1.72.83.2-1.61.6-1.8-1.7
Bone: tissue strength0.10.10.10.2-0.20.20.4
Total heroin consumption1.61.93.01.7-1.61.20.8
Bone: trabecular number2.54.85.32.2-1.92.32.2
Bone: trabecular spacing0.10.10.3-0.50.3-0.3-0.3
Bone: trabecular thickness1.72.33.82.0-1.71.20.9
Bone: trabecular tissue density1.73.03.7-1.51.5-1.9-1.9
Water consumed over 24 hours0.20.40.5-0.70.6-0.6-0.6
Number of responses in last shaping day0.50.60.8-0.70.6-0.9-0.9