Pmm1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Pmm1	0.11	0.05	2.5e-15	0.09	0.11	0.11	0.11	7.4e-10	1.3e-12	5.1e-12	5.2e-12
2	BLA	gene expression	Pmm1	0.25	0.11	5.0e-14	0.22	0.21	0.22	0.23	6.0e-12	1.6e-11	4.8e-12	1.2e-12
3	PL	gene expression	Pmm1	0.23	0.09	0.0e+00	0.26	0.25	0.23	0.26	6.4e-28	3.1e-27	2.0e-25	2.4e-28
4	NAcc	gene expression	Pmm1	0.21	0.1	0.0e+00	0.18	0.2	0.2	0.2	3.6e-20	2.8e-22	7.0e-23	2.9e-23
5	Brain	gene expression	Pmm1	0.39	0.11	0.0e+00	0.49	0.51	0.51	0.52	4.9e-52	4.6e-55	6.9e-54	2.5e-55
6	pVTA	gene expression	Pmm1	0.68	0.14	0.0e+00	0.45	0.17	0.44	0.44	1.3e-21	4.9e-08	1.4e-20	9.1e-21
7	RMTg	gene expression	Pmm1	0.15	0.08	4.0e-04	0.05	0.11	0.06	0.06	1.6e-02	8.8e-04	1.0e-02	8.4e-03
8	PL	mRNA stability	Pmm1	0.02	0.01	3.5e-03	0	0.01	0.01	-0	7.9e-02	9.5e-03	7.1e-02	4.1e-01
9	LHb	gene expression	Pmm1	0.29	0.13	7.8e-06	0.24	0.25	0.22	0.25	1.6e-06	1.4e-06	6.5e-06	1.4e-06
10	IL	gene expression	Pmm1	0.28	0.13	2.3e-04	-0.01	0.02	0.01	0.01	7.0e-01	1.0e-01	1.9e-01	1.7e-01
11	Brain	mRNA stability	Pmm1	0.05	0.03	9.0e-06	0.04	0.06	0.06	0.06	1.5e-04	3.3e-06	1.9e-06	3.1e-06
12	OFC	gene expression	Pmm1	0.39	0.18	1.4e-05	0.1	0.15	0.09	0.1	1.9e-03	2.0e-04	4.6e-03	2.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12
Bone: apparent density	0.3	0.6	1.1	0.8	0.7	0.8	0.7	0.7	-0.6	0.9	-0.6	0.7	0.8	0.5	1.1
Area under the delay curve	0.2	0.2	0.6	0.6	0.7	0.2	0.4	0.4	-0.4	0.1	-0.3	0.0	-0.0	0.2	-0.8
BMI with tail	1.2	4.0	6.4	-1.6	-2.4	-2.2	-2.3	-2.1	2.3	-1.8	2.5	-2.4	-0.8	-2.0	-0.3
BMI without tail	0.1	0.2	1.0	-0.3	-0.4	-0.1	-0.2	-0.2	0.0	0.2	0.1	0.0	0.6	0.2	1.0
Body weight	1.5	6.5	9.7	-2.5	-2.9	-2.8	-2.7	-2.9	3.1	-2.5	2.6	-2.5	-1.9	-2.5	-0.9
Weight adjusted by age	0.1	0.2	0.9	-0.5	-0.2	-0.1	-0.1	-0.1	-0.3	-0.3	-0.2	0.5	-1.0	0.0	-0.5
Bone surface	0.1	0.2	0.9	0.1	0.2	0.4	0.2	0.3	-0.4	0.3	-0.5	0.9	-0.5	0.5	0.2
Bone volume	0.0	0.0	0.2	-0.1	0.1	0.2	0.1	0.1	-0.1	0.1	-0.2	0.5	-0.2	0.2	0.2
Breakpoint value in progressive ratio session	0.2	0.2	1.0	0.5	0.2	0.2	0.2	0.4	-0.4	0.6	0.0	0.1	0.8	-0.0	1.0
Number of licking bursts	0.4	0.4	0.7	0.7	0.7	0.7	0.8	0.7	-0.8	0.5	-0.6	0.7	-0.0	0.7	-0.2
Context. condit. distance diff. score	6.7	8.0	11.2	-3.3	-3.0	-3.0	-2.9	-3.1	3.0	-3.1	2.4	-2.5	-2.6	-2.5	-2.4
Locomotion velocity, session 1	0.4	0.4	2.4	-0.5	-0.2	-0.2	-0.3	-0.3	-0.1	-0.5	-0.1	0.5	-1.5	0.4	-1.1
Locomotion distance, session 1	1.9	2.4	4.0	1.4	1.8	1.7	1.8	1.6	-1.7	1.2	-1.8	1.9	0.0	2.0	-0.4
Locomotion velocity, session 2	0.2	0.2	0.5	-0.7	-0.5	-0.5	-0.5	-0.5	0.4	-0.6	0.4	-0.1	-0.7	-0.3	-0.2
Locomotion distance, session 2	2.4	3.3	6.0	2.4	2.0	2.0	1.9	2.1	-2.1	1.9	-1.4	1.5	1.4	1.6	1.2
Locomotion velocity, session 3	0.4	0.5	1.4	-1.0	-0.3	-0.5	-0.5	-0.6	0.5	-0.8	0.0	0.0	-1.2	0.1	-1.2
Locomotion distance, session 3	1.0	1.1	2.3	0.5	1.3	0.9	1.2	0.7	-0.9	0.4	-1.4	1.2	-0.4	1.5	-1.2
Stereotopy head waving bouts, day 3	0.8	0.9	1.5	-1.0	-1.2	-1.0	-1.2	-1.1	1.1	-0.9	1.0	-0.7	-0.9	-1.0	-0.1
Stereotopy head waving duration, day 3	3.0	3.6	5.4	-2.3	-2.3	-2.0	-2.3	-2.1	2.0	-1.8	1.9	-1.3	-1.7	-1.9	-0.3
Locomotion velocity, session 7	0.2	0.3	0.8	-0.6	-0.0	-0.5	-0.2	-0.6	0.6	-0.7	0.1	-0.3	-0.7	0.0	-0.9
Locomotion distance, session 7	0.1	0.2	0.5	0.6	0.7	0.1	0.5	0.2	0.2	0.0	-0.1	-0.4	0.3	0.1	-0.6
Stereotopy head waving bouts, day 7	2.9	3.2	6.7	-2.6	-2.1	-1.9	-2.1	-2.1	1.6	-1.9	1.2	-0.6	-2.4	-1.0	-1.0
Stereotopy head waving duration, day 7	1.9	2.3	5.7	-2.4	-1.8	-1.6	-1.8	-1.8	1.5	-1.6	0.9	-0.5	-1.7	-0.8	-0.6
Locomotion velocity, session 8	2.2	2.7	3.7	-1.6	-1.9	-1.6	-1.8	-1.6	1.4	-1.7	1.8	-1.4	-1.8	-1.7	-1.1
Locomotion distance, session 8	0.8	1.1	2.0	-1.4	-1.0	-1.1	-1.1	-1.1	0.9	-1.2	0.9	-0.9	-1.1	-0.9	-1.1
Degree of sensitization distance	2.1	2.1	4.5	-0.8	-1.5	-1.5	-1.5	-1.2	1.6	-1.0	1.9	-2.1	0.2	-2.1	0.4
Degree of sensitization stereotypy	2.1	2.3	4.7	-2.2	-1.6	-1.5	-1.6	-1.8	1.3	-1.6	0.7	-0.4	-2.2	-0.6	-1.3
Conditioned locomotion	0.6	0.7	1.6	-1.3	-0.8	-0.8	-0.7	-0.9	0.7	-1.1	0.5	-0.6	-0.9	-0.4	-1.2
Cocaine response after cond. corrected	0.0	0.0	0.1	-0.4	-0.2	-0.1	-0.1	-0.2	0.3	-0.2	-0.0	0.0	-0.3	0.1	-0.2
Cocaine response after cond. not corrected	0.0	0.0	0.2	-0.4	-0.1	0.1	0.0	-0.0	0.0	-0.1	-0.1	0.2	-0.1	0.2	0.0
Cocaine response before conditioning	0.2	0.2	0.4	0.2	0.4	0.4	0.3	0.5	-0.7	0.4	-0.3	0.4	0.6	0.3	0.5
Saline control response	0.1	0.2	1.0	-1.0	-0.4	0.0	-0.1	-0.0	-0.4	-0.4	-0.2	0.5	-0.4	0.1	-0.6
Bone: connectivity density	0.1	0.2	0.6	0.5	0.3	0.5	0.4	0.3	-0.2	0.6	-0.3	0.4	0.5	0.2	0.8
Bone: cortical apparent density	0.5	0.6	1.1	1.1	1.0	0.9	0.8	0.8	-1.0	0.7	-0.7	0.7	0.4	0.8	0.1
Bone: cortical area	1.5	2.2	3.3	-1.5	-1.6	-1.7	-1.8	-1.6	1.4	-1.5	1.6	-1.3	-1.4	-1.4	-0.5
Bone: cortical porosity	0.3	0.3	0.8	-0.9	-0.5	-0.6	-0.7	-0.6	0.6	-0.5	0.6	-0.5	-0.1	-0.7	0.3
Bone: cortical porosity	0.9	1.0	1.7	-1.3	-1.1	-1.1	-1.2	-1.2	1.1	-0.9	1.0	-0.8	-0.5	-1.0	0.2
Bone: cortical thickness	0.2	0.4	1.1	0.3	-0.4	-0.6	-0.6	-0.4	0.5	-0.3	1.1	-1.1	0.0	-0.9	0.2
Bone: cortical thickness	0.4	0.5	1.3	0.2	-0.6	-0.7	-0.7	-0.5	0.5	-0.5	1.1	-1.1	-0.2	-1.0	-0.3
Bone: cortical tissue density	0.4	0.6	1.1	1.0	0.9	0.8	0.8	0.8	-0.9	0.7	-0.7	0.6	0.3	0.8	0.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	0.8	0.7	0.4	0.3	0.5	-0.3	0.4	-0.0	0.1	0.4	0.2	0.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	-0.5	-0.5	-0.6	-0.7	-0.6	0.6	-0.6	0.5	-0.4	-0.7	-0.4	-0.4
Condit. Reinf. active responses	1.4	1.8	2.5	1.6	1.6	1.4	1.4	1.6	-1.4	1.4	-0.9	0.9	1.5	0.9	1.1
Condit. Reinf. inactive responses	3.0	3.6	4.9	1.9	2.0	1.9	2.0	2.1	-2.2	2.0	-1.7	1.5	2.2	1.4	1.5
Incentive salience index mean	0.5	0.6	1.6	1.3	1.1	0.8	0.7	0.9	-0.7	0.8	-0.3	0.3	0.8	0.3	0.6
Condit. Reinf. lever presses	0.8	1.1	2.0	1.3	1.4	1.0	1.0	1.2	-1.1	1.0	-0.7	0.6	1.2	0.6	0.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	0.6	-0.0	-0.1	-0.4	0.0	-0.0	-0.0	0.6	-0.4	-0.4	-0.3	-0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	0.6	-0.2	-0.3	-0.6	-0.2	0.4	0.0	0.8	-0.6	-0.1	-0.6	0.5
Condit. Reinf. active responses	0.6	0.8	1.6	-0.4	-0.8	-0.9	-1.1	-0.7	0.5	-0.9	1.1	-0.8	-1.3	-0.8	-0.9
Condit. Reinf. inactive responses	1.2	1.5	3.0	-1.2	-1.0	-1.2	-1.1	-1.1	0.8	-1.5	1.0	-0.9	-1.6	-1.0	-1.7
Condit. Reinf. lever presses	0.3	0.4	0.9	1.0	0.5	0.8	0.4	0.7	-0.7	0.7	-0.2	0.5	0.5	0.2	0.9
Condit. Reinf. lever reinforcers received	0.2	0.3	0.7	-0.1	-0.5	-0.5	-0.8	-0.4	0.3	-0.5	0.8	-0.6	-0.9	-0.6	-0.5
Conditioned reinforcement - actives	0.9	0.9	3.4	-0.6	-0.6	-0.9	-0.7	-0.6	0.2	-1.1	0.6	-0.7	-1.6	-0.3	-1.9
Conditioned reinforcement - inactives	0.1	0.1	0.6	0.8	0.0	-0.1	-0.0	0.4	-0.5	0.2	0.3	-0.2	0.3	-0.6	0.2
Conditioned locomotion	2.1	2.6	3.6	-1.1	-1.5	-1.8	-1.8	-1.6	1.4	-1.7	1.9	-1.8	-1.7	-1.6	-1.2
Patch foraging indifference point 0 sec	0.6	1.0	2.8	1.2	0.6	0.9	0.7	1.1	-1.2	1.2	-0.4	0.7	1.2	0.4	1.7
Patch foraging indifference point AUC	0.2	0.2	1.0	0.4	0.3	0.3	0.3	0.2	-0.2	-0.1	-0.2	0.2	-0.8	0.6	-1.0
Delay disc. indifference point, 0s delay	0.6	0.7	1.7	-0.9	-0.8	-1.0	-0.7	-0.8	0.6	-0.8	1.0	-1.1	0.0	-1.3	0.1
Delay disc. indifference point, 16s delay	1.3	1.3	2.1	1.5	1.4	1.3	1.3	1.3	-0.9	1.1	-1.2	1.0	0.7	1.2	0.1
Delay disc. indifference point, 2s delay	0.2	0.2	1.0	-0.1	0.0	-0.5	-0.2	-0.3	0.1	-0.6	0.4	-0.7	-0.4	-0.5	-1.0
Delay disc. indifference point, 24s delay	0.4	0.4	2.1	0.1	0.4	0.0	0.2	-0.0	0.1	-0.4	-0.3	0.3	-1.4	0.6	-1.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	0.6	-0.0	-0.1	-0.1	0.2	-0.3	0.0	0.5	-0.4	0.1	-0.5	-0.1
Delay disc. indifference point, 8s delay	0.6	0.6	1.5	1.0	1.2	0.7	0.9	0.9	-0.7	0.6	-0.8	0.5	0.4	0.7	-0.5
Indifference point function ln k	0.8	1.2	1.9	-1.3	-1.4	-1.1	-1.2	-1.2	1.3	-0.9	1.1	-1.0	-0.4	-1.4	0.1
Indifference point function log k	0.8	1.2	1.9	-1.3	-1.4	-1.1	-1.2	-1.2	1.3	-0.9	1.1	-1.0	-0.4	-1.4	0.1
Patch foraging total patch changes 0 sec	0.8	1.2	2.9	1.3	0.7	1.0	0.8	1.2	-1.4	1.3	-0.5	0.8	1.3	0.5	1.7
Patch foraging total patch changes 12 sec	0.0	0.0	0.2	0.4	0.0	0.1	0.0	0.2	-0.3	0.2	0.3	-0.0	0.0	0.0	0.3
Patch foraging total patch changes 18 sec	0.2	0.2	0.7	0.9	0.1	0.3	0.1	0.5	-0.8	0.5	0.1	0.1	0.4	0.1	0.7
Patch foraging total patch changes 24 sec	0.2	0.3	0.8	0.6	0.6	0.5	0.5	0.6	-0.9	0.5	-0.5	0.5	0.2	0.6	0.1
Patch foraging total patch changes 6 sec	0.3	0.4	1.0	1.0	0.3	0.7	0.4	0.9	-1.0	0.7	0.0	0.5	0.4	0.5	0.9
Patch foraging time to switch 0 sec	0.1	0.2	1.0	-0.1	0.7	0.2	0.3	0.0	-0.0	0.4	-0.4	0.3	0.8	0.2	1.0
Patch foraging water rate 0 sec	0.2	0.3	0.6	0.7	-0.4	0.6	0.2	0.7	-0.6	0.6	0.1	0.4	0.5	0.2	0.8
Patch foraging water rate 12 sec	0.3	0.5	0.9	0.5	0.1	0.7	0.5	0.7	-1.0	0.8	-0.7	0.9	0.5	0.8	0.8
Patch foraging water rate 18 sec	1.3	1.8	2.7	1.3	1.1	1.6	1.3	1.4	-1.5	1.5	-1.2	1.6	0.8	1.2	1.3
Patch foraging water rate 24 sec	0.1	0.2	0.9	0.1	-0.7	-0.0	-0.5	0.0	0.0	0.3	0.4	0.0	0.2	0.1	1.0
Patch foraging water rate 6 sec	0.7	1.0	2.4	0.6	0.6	1.1	0.9	1.0	-1.2	0.9	-1.2	1.6	0.2	1.3	0.4
Seeking ratio, delayed vs. immediate footshock	3.7	4.2	5.7	2.4	2.2	2.2	2.1	2.1	-1.9	2.2	-1.8	1.6	2.1	2.2	1.8
Distance traveled before self-admin	0.2	0.2	0.9	0.8	0.2	0.0	0.0	0.3	-0.0	0.2	0.4	-0.8	0.9	-0.2	0.3
Distance traveled after self-admin	0.2	0.2	0.6	0.5	-0.5	-0.1	-0.5	0.1	-0.2	0.1	0.8	-0.4	0.1	-0.3	0.6
Extensor digitorum longus weight	0.2	0.9	1.2	0.5	0.7	1.0	0.9	1.0	-1.1	1.0	-0.8	1.0	1.1	0.9	1.1
Bone: elastic displacement	0.2	0.2	0.7	-0.7	-0.5	-0.2	-0.3	-0.3	0.0	-0.3	-0.1	0.4	-0.8	0.1	-0.3
Bone: elastic work	1.8	2.3	3.6	-1.7	-1.9	-1.7	-1.9	-1.7	1.6	-1.3	1.6	-1.2	-1.1	-1.6	0.1
Bone: endosteal estimation	0.8	1.8	5.3	-2.3	-1.7	-1.2	-1.5	-1.4	1.1	-1.4	0.7	-0.1	-1.9	-0.6	-0.7
Bone: endosteal perimeter	1.8	3.8	9.0	-3.0	-2.1	-2.1	-2.1	-2.2	1.9	-2.2	1.2	-0.8	-2.4	-1.0	-1.3
Epididymis fat weight	3.5	8.1	11.6	-3.4	-2.8	-3.1	-2.8	-3.3	3.0	-3.2	2.2	-2.6	-2.8	-1.9	-2.7
Delta time in closed arm before/after self-admin	1.6	1.6	2.7	-0.8	-1.0	-1.2	-1.2	-1.0	1.1	-1.4	1.5	-1.6	-1.1	-1.2	-1.5
Delta time in open arm before/after self-admin	0.3	0.3	0.9	0.0	0.4	0.4	0.5	0.3	-0.9	0.5	-0.9	0.9	0.3	0.6	0.4
Diff in mean of infusions in LGA sessions	0.3	0.3	0.9	0.9	0.6	0.7	0.7	0.6	-0.3	0.5	-0.4	0.2	0.3	0.3	0.1
Delay discount exponential model param	0.2	0.2	0.7	-0.6	-0.7	-0.3	-0.5	-0.5	0.5	-0.1	0.3	-0.1	0.1	-0.3	0.9
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.2	0.1	0.1	0.0	0.1	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.1
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.2	-0.2	-0.0	-0.3	-0.1	0.2	-0.1	0.5	-0.4	0.2	-0.4	0.2
Bone: final force	1.4	2.3	3.9	-0.7	-1.5	-1.6	-1.7	-1.5	1.9	-1.3	2.0	-1.8	-1.0	-1.9	-0.2
Bone: final moment	1.6	2.6	4.4	-0.9	-1.7	-1.7	-1.9	-1.6	1.9	-1.3	2.1	-1.8	-1.1	-1.9	-0.2
Food consumed during 24 hour testing period	1.5	1.7	2.8	-0.9	-1.3	-1.4	-1.4	-1.4	1.7	-1.2	1.6	-1.5	-0.8	-1.5	-0.3
Glucose	0.6	0.9	2.3	0.9	0.7	0.9	0.8	0.9	-0.9	1.1	-0.6	0.6	1.4	0.6	1.5
Heart weight	2.1	3.0	5.4	-1.3	-2.2	-2.0	-2.2	-1.5	1.4	-1.3	2.3	-2.0	-0.3	-2.3	0.3
Delay discount hyperbolic model param	0.1	0.1	0.8	-0.5	-0.5	-0.1	-0.3	-0.3	0.4	0.1	0.1	0.1	0.2	-0.1	0.9
Intermittent access intake day 1-15 change	0.3	0.3	0.5	0.7	0.5	0.5	0.6	0.7	-0.6	0.5	-0.5	0.4	0.4	0.5	0.1
Intermittent access intake escalation	0.4	0.4	0.7	0.8	0.6	0.6	0.7	0.8	-0.8	0.6	-0.6	0.5	0.6	0.5	0.3
Intermittent access intake escalation 2	0.2	0.2	0.3	0.3	0.4	0.3	0.4	0.5	-0.5	0.4	-0.4	0.5	0.4	0.1	0.3
Intermitt. access day 1 inactive lever presses	0.5	0.5	1.8	0.2	-0.9	-0.6	-0.8	-0.3	0.2	-0.0	1.1	-0.8	0.4	-1.3	0.9
Intermitt. access day 15 inactive lever presses	0.7	0.8	2.5	0.3	-1.0	-0.7	-1.1	-0.4	0.4	-0.5	1.6	-1.5	-0.1	-1.3	-0.3
Intermitt. access escalation Index	0.1	0.1	0.4	0.6	-0.0	-0.0	-0.1	0.1	-0.0	0.3	0.3	-0.1	0.3	-0.0	0.6
Intermittent access day 1 total infusions	1.0	1.2	1.8	-0.7	-1.2	-1.3	-1.3	-1.0	0.6	-1.1	1.3	-1.3	-1.0	-1.1	-0.8
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.4	-0.2	-0.3	-0.2	0.1	-0.4	-0.0	0.3	-0.3	-0.1	-0.3	-0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	-0.1	-0.3	-0.5	-0.2	-0.2	0.0	-0.4	0.3	-0.4	-0.4	-0.4	-0.6
Intermittent access total infusions	0.3	0.4	0.7	-0.2	-0.6	-0.8	-0.7	-0.5	0.5	-0.5	0.7	-0.8	-0.4	-0.7	-0.3
Intermittent access day 1 locomotion	0.4	0.4	0.7	-0.3	-0.7	-0.8	-0.8	-0.6	0.4	-0.5	0.9	-0.8	-0.2	-0.8	-0.0
Intermittent access day 15 total locomotion	0.2	0.2	0.3	-0.2	-0.4	-0.6	-0.5	-0.4	0.5	-0.4	0.4	-0.4	-0.4	-0.6	-0.2
Intermittent access total locomotion	0.4	0.5	0.9	-0.2	-0.7	-0.9	-0.9	-0.7	0.8	-0.6	0.9	-1.0	-0.4	-0.8	-0.1
Intermittent access standard deviation	0.6	0.6	1.2	-0.3	-0.9	-1.1	-0.9	-0.6	0.5	-0.5	1.0	-1.1	-0.0	-0.9	0.1
Left kidney weight	12.6	35.4	43.7	-5.8	-6.5	-6.4	-6.6	-6.3	6.2	-6.1	6.3	-5.7	-5.5	-5.8	-3.8
Right kidney weight	13.5	38.0	46.0	-5.8	-6.8	-6.7	-6.8	-6.4	6.3	-6.3	6.7	-6.1	-5.6	-6.1	-3.9
Cocaine induced anxiety	0.6	0.7	2.0	-0.3	-0.8	-0.6	-0.8	-0.8	1.4	-0.4	1.1	-1.2	0.3	-0.4	0.8
Post-drug Anxiety	0.2	0.2	0.8	0.0	-0.5	-0.1	-0.4	-0.4	0.6	-0.0	0.7	-0.5	0.2	0.1	0.9
Baseline Anxiety	0.9	1.0	1.9	0.7	1.1	1.1	1.2	1.0	-1.4	0.8	-1.3	1.4	0.2	0.9	-0.1
Tail length	0.2	0.5	1.1	0.2	0.6	0.6	0.7	0.6	-0.8	0.7	-1.0	1.0	0.5	0.6	0.5
Length with tail	0.4	1.4	2.1	-1.3	-1.2	-1.2	-1.2	-1.4	1.4	-1.2	0.8	-0.6	-1.4	-1.2	-0.7
Length without tail	1.4	3.1	5.0	-1.3	-1.7	-1.7	-1.8	-1.8	2.2	-1.8	1.8	-1.6	-2.0	-1.8	-1.3
Times rat made contact with spout	0.8	0.9	1.4	-0.4	-1.0	-0.9	-0.9	-0.8	1.0	-1.0	1.2	-1.1	-0.8	-1.2	-1.0
Lifetime Intake	0.9	1.0	2.1	-0.2	-1.0	-1.2	-1.1	-0.8	0.8	-0.8	1.4	-1.4	-0.5	-1.3	-0.4
Liver weight, left	0.9	1.4	3.3	-1.8	-1.1	-1.3	-1.1	-1.4	1.1	-1.3	0.6	-0.5	-1.4	-0.7	-1.1
Liver weight, right	2.5	4.1	8.2	-2.9	-1.8	-2.2	-1.8	-2.3	2.3	-2.4	1.2	-1.4	-2.1	-1.3	-2.1
Locomotor activity	1.8	2.8	4.1	-2.0	-2.0	-1.7	-1.9	-1.9	2.0	-1.6	1.5	-1.2	-1.6	-1.3	-0.6
Locomotor testing distance	0.0	0.0	0.0	0.0	0.1	0.1	0.0	0.1	0.1	0.1	-0.1	0.2	-0.0	0.2	0.1
Locomotor testing rearing	1.5	2.3	3.1	-1.7	-1.7	-1.8	-1.6	-1.6	1.5	-1.6	1.3	-1.4	-1.3	-1.3	-1.2
Locomotion in novel chamber	0.7	0.8	3.2	-0.3	0.7	0.4	0.4	0.7	-1.8	0.3	-1.3	1.5	-0.3	1.1	-0.4
Locomotion in novel chamber post-restriction	0.9	1.1	1.9	0.8	1.4	1.1	1.1	1.1	-1.0	0.9	-1.3	1.0	0.8	1.1	0.3
Fecal boli incidents, locomotor time 1	0.4	0.4	0.7	0.7	0.7	0.9	0.7	0.7	-0.4	0.6	-0.5	0.6	0.5	0.6	0.4
Change in fecal boli incidents, locomotor task	1.2	1.2	3.9	-0.9	-0.8	-1.0	-0.9	-1.2	0.8	-1.2	0.4	-0.4	-2.0	-0.1	-1.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.1	-0.0	-0.2	-0.1	-0.3	0.5	-0.1	0.2	-0.2	-0.1	-0.2	0.2
Bouts of movement, locomotor time 1	0.3	0.3	1.2	-0.4	-0.3	-0.5	-0.3	-0.7	1.1	-0.6	0.3	-0.7	-0.5	-0.1	-0.7
Total resting periods, locomotor time 1	0.1	0.1	0.8	0.1	0.0	-0.2	-0.0	-0.4	0.9	-0.2	0.2	-0.6	0.0	-0.1	-0.2
Rest time, locomotor task time 1	0.4	0.4	1.4	0.2	-0.2	-0.5	-0.4	-0.5	1.1	-0.3	0.8	-1.2	0.3	-0.8	-0.0
Distance moved, locomotor task time 1	0.5	0.5	1.5	-1.2	-0.7	-0.8	-0.7	-0.6	0.3	-0.8	0.5	-0.3	-0.7	-0.9	-0.5
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.2	-0.2	-0.0	-0.1	0.2	-0.3	0.1	-0.0	0.2	0.1	-0.3	0.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.3	0.4	0.3	0.5	0.2	-0.3	0.3	-0.3	0.4	0.1	0.3	0.5
Bouts of movement, locomotor time 2	0.3	0.4	1.0	0.1	-0.5	-0.7	-0.6	-0.6	0.7	-0.3	0.8	-1.0	0.2	-0.7	0.1
Total resting periods, locomotor time 2	0.3	0.3	0.9	0.3	-0.4	-0.5	-0.5	-0.5	0.6	-0.2	0.8	-1.0	0.2	-0.6	0.1
Rest time, locomotor task time 2	0.1	0.1	0.4	0.7	0.4	0.4	0.4	0.3	0.0	0.2	-0.1	0.0	0.1	0.4	-0.2
Distance moved, locomotor task time 2	0.8	0.9	1.8	-1.4	-0.9	-1.2	-0.9	-0.9	0.5	-1.1	0.7	-0.8	-0.7	-1.2	-0.7
Vertical activity count, locomotor time 2	0.3	0.4	0.8	-0.9	-0.7	-0.7	-0.6	-0.6	0.3	-0.6	0.5	-0.4	-0.5	-0.8	-0.2
Light reinforcement 1	0.1	0.2	0.9	-0.8	-0.3	-0.3	-0.5	-0.2	-0.5	-0.5	0.0	0.3	-1.0	0.3	-0.5
Light reinforcement 2	0.6	0.8	1.5	-1.2	-0.7	-1.0	-0.9	-0.9	1.0	-1.1	0.7	-0.9	-0.7	-0.6	-0.7
Bone: marrow area	0.9	2.0	5.6	-2.4	-1.8	-1.3	-1.6	-1.5	1.1	-1.5	0.8	-0.1	-1.9	-0.7	-0.7
Bone: maximum diameter	4.0	7.3	10.2	-3.0	-3.1	-3.0	-3.2	-2.9	2.7	-2.7	2.7	-2.2	-2.6	-2.5	-1.2
Bone: maximum force	2.5	4.3	6.7	-1.5	-2.3	-2.2	-2.4	-2.1	2.3	-1.9	2.6	-2.3	-1.6	-2.3	-0.6
Bone: maximum moment	2.8	4.8	7.4	-1.7	-2.5	-2.3	-2.6	-2.3	2.4	-2.0	2.7	-2.3	-1.7	-2.4	-0.6
Mean time between licks in bursts	0.6	0.8	1.1	0.9	1.1	0.8	1.0	1.0	-0.9	0.9	-0.9	0.7	1.0	0.8	0.6
Mean num. licks in bursts	1.9	2.3	3.0	-1.4	-1.6	-1.6	-1.6	-1.6	1.7	-1.5	1.5	-1.6	-1.1	-1.7	-1.0
Cd content in liver	0.9	1.0	1.8	-1.3	-1.2	-1.1	-0.9	-0.9	0.8	-1.2	0.8	-0.8	-0.9	-0.8	-1.2
Co content in liver	0.3	0.3	0.7	-0.4	-0.8	-0.4	-0.5	-0.3	0.5	-0.5	0.9	-0.8	-0.2	-0.7	-0.2
Cu content in liver	4.1	5.0	6.2	2.2	2.5	2.3	2.3	2.4	-2.4	2.4	-2.2	2.2	2.1	1.9	1.8
Fe content in liver	0.1	0.1	0.6	-0.6	-0.4	-0.0	-0.3	-0.0	-0.1	0.1	-0.0	0.4	0.2	-0.3	0.8
K content in liver	0.7	0.7	1.4	1.2	0.7	0.9	0.6	1.0	-0.9	1.0	-0.3	0.6	0.8	0.3	1.1
Mg content in liver	1.4	1.5	3.0	1.7	1.2	1.1	0.8	1.3	-1.2	1.4	-0.5	0.7	1.4	0.4	1.7
Mn content in liver	0.3	0.4	1.7	-0.7	-0.1	-0.5	-0.3	-0.4	0.2	-0.8	0.2	-0.3	-1.0	-0.0	-1.3
Na content in liver	3.0	3.2	4.0	1.8	1.9	2.0	1.9	1.9	-1.8	1.9	-1.7	1.6	1.8	1.6	1.4
Rb content in liver	0.0	0.0	0.1	0.3	0.0	0.0	-0.1	0.2	-0.1	0.1	0.2	-0.1	-0.0	-0.2	0.1
Se content in liver	0.7	0.8	1.3	0.5	0.9	1.0	1.0	0.9	-1.0	0.8	-1.1	1.1	0.4	1.1	0.2
Sr content in liver	0.8	0.8	1.4	0.8	1.1	0.9	1.2	1.0	-1.0	0.7	-1.0	0.6	0.7	0.9	-0.2
Zn content in liver	1.2	1.3	2.0	0.9	1.2	1.3	1.2	1.2	-1.3	1.1	-1.3	1.4	0.7	1.2	0.8
Bone: minimum diameter	0.6	1.1	2.5	-1.6	-1.1	-1.2	-1.3	-1.2	0.9	-1.1	0.7	-0.4	-1.3	-0.5	-0.5
Time in familiar zone, hab. session 1	0.3	0.3	1.5	-0.3	0.0	-0.4	-0.3	-0.4	0.3	-0.6	0.1	-0.2	-1.1	0.0	-1.2
Time in novel zone, hab. session 1	0.4	0.4	1.4	-1.0	-1.2	-0.5	-0.7	-0.6	0.5	-0.3	0.6	-0.3	0.2	-0.5	0.8
Total zone transitions, hab. session 1	2.7	3.8	5.6	1.7	2.2	2.2	2.2	2.1	-2.2	1.6	-2.3	2.3	0.4	2.4	-0.4
Total locomotion distance, hab. session 1	1.4	2.0	4.4	0.4	1.4	1.4	1.4	1.3	-1.6	0.8	-1.9	2.1	-0.3	2.0	-0.7
Locomotion velocity, hab. session 1	1.7	2.4	4.5	0.9	1.7	1.6	1.6	1.6	-1.9	1.1	-2.0	2.1	0.1	2.0	-0.3
Time in familiar zone, hab. session 2	0.2	0.2	0.8	-0.8	0.3	-0.3	0.1	-0.3	0.1	-0.4	-0.6	0.3	-0.5	0.3	-0.9
Time in novel zone, hab. session 2	0.2	0.2	0.6	0.3	-0.8	0.1	-0.4	0.1	-0.0	0.1	0.7	-0.3	0.2	-0.3	0.6
Total zone transitions, hab. session 2	0.6	0.8	1.6	1.2	0.9	1.1	0.9	1.2	-1.3	0.8	-0.6	0.9	0.1	0.7	-0.0
Total locomotion distance, hab. session 2	0.7	0.9	1.7	1.0	0.9	1.1	0.9	1.1	-1.3	0.9	-0.7	1.0	0.6	1.0	0.5
Locomotion velocity, hab. session 2	1.2	1.7	2.8	1.4	1.4	1.4	1.3	1.5	-1.7	1.3	-1.1	1.3	0.8	1.4	0.7
Novel to familiar place preference ratio	2.6	2.7	5.6	-2.1	-2.4	-1.6	-1.8	-1.8	1.8	-1.6	1.3	-1.0	-1.7	-1.3	-0.9
Novelty place preference	3.7	3.8	7.1	-2.4	-2.7	-1.9	-2.1	-2.1	2.1	-2.0	1.5	-1.2	-2.1	-1.4	-1.3
Time in novel zone, NPP test	4.6	4.7	8.8	-2.7	-3.0	-2.1	-2.3	-2.4	2.3	-2.2	1.8	-1.4	-2.3	-1.7	-1.5
Total zone transitions, NPP test	2.2	3.1	4.9	1.6	2.0	1.9	1.9	1.9	-2.2	1.4	-1.9	2.0	0.2	2.1	-0.4
Total locomotion distance, NPP test	1.1	1.5	2.3	1.2	1.3	1.4	1.3	1.3	-1.5	1.1	-1.3	1.4	0.4	1.5	0.2
Locomotion velocity, NPP test	1.9	2.7	3.8	1.5	1.9	1.8	1.8	1.7	-1.9	1.5	-1.8	1.8	0.8	1.9	0.3
Intraocular pressure	0.5	0.7	2.0	-0.8	-0.5	-0.9	-0.7	-0.9	0.6	-1.0	0.4	-0.6	-1.2	-0.4	-1.4
Delta distance traveled before/after self-admin	0.7	0.7	2.8	-0.9	-1.1	-0.6	-0.9	-0.7	0.3	-0.8	0.6	0.0	-1.7	-0.4	-0.7
Delta ambulatory time before/after self-admin	0.7	0.8	3.1	-0.9	-1.3	-0.6	-1.1	-0.7	0.2	-0.8	0.8	0.1	-1.8	-0.6	-0.5
Parametrial fat weight	0.1	0.2	0.6	-0.2	-0.4	-0.3	-0.2	-0.3	0.4	-0.4	0.6	-0.8	0.0	-0.6	-0.3
Pavlov. Cond. lever latency	1.1	1.4	2.1	-1.4	-1.5	-1.2	-1.2	-1.3	1.3	-1.2	0.9	-0.9	-1.3	-0.7	-1.0
Pavlov. Cond. magazine entry latency	0.9	1.1	2.6	1.6	1.3	1.1	1.2	1.2	-1.0	1.1	-0.6	0.4	1.2	0.6	0.7
Pavlov. Cond. change in total contacts	1.2	1.3	3.4	1.9	1.3	1.1	1.1	1.4	-1.2	1.2	-0.4	0.4	1.3	0.5	0.9
Pavlov. Cond. index score	0.5	0.6	1.8	1.3	0.9	0.7	0.8	0.9	-0.6	0.7	-0.1	-0.0	1.1	0.1	0.6
Pavlov. Cond. latency score	0.4	0.6	1.5	1.2	0.8	0.7	0.7	0.9	-0.7	0.8	-0.1	0.0	1.1	0.1	0.7
Pavlov. Cond. lever contacts	1.4	1.7	2.7	1.6	1.6	1.3	1.3	1.5	-1.4	1.3	-0.9	0.7	1.6	0.8	1.0
Pavlov. Cond. magazine entry number	0.5	0.6	1.8	-1.3	-1.0	-0.8	-1.0	-0.9	0.7	-0.7	0.4	-0.1	-0.9	-0.3	-0.2
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.7	1.3	0.9	1.2	1.0	1.2	-1.0	1.3	-0.8	1.0	0.9	0.9	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	2.1	1.4	1.1	0.8	0.9	1.0	-0.8	0.8	-0.3	0.1	1.1	0.3	0.5
Pavlov. Cond. response bias	0.9	1.1	2.6	1.6	1.4	1.0	1.2	1.2	-0.9	1.0	-0.5	0.3	1.3	0.4	0.7
Pavlov. Cond. lever latency	1.4	1.9	5.3	-1.4	-1.0	-1.4	-1.0	-1.4	1.3	-1.6	0.7	-1.3	-1.4	-0.6	-2.3
Pavlov. Cond. magazine entry latency	4.2	4.9	8.8	3.0	2.0	2.4	2.0	2.3	-1.9	2.7	-1.4	1.6	2.5	1.4	2.8
Pavlov. Cond. change in total contacts	1.2	1.6	7.7	1.9	0.5	1.1	0.4	1.1	-0.7	1.5	0.3	0.4	1.5	-0.2	2.8
Pavlov. Cond. index score	2.9	3.7	7.3	2.5	1.6	2.1	1.6	2.0	-1.6	2.3	-1.0	1.4	2.1	1.0	2.7
Pavlov. Cond. latency score	3.5	4.3	8.0	2.8	1.8	2.3	1.8	2.2	-1.8	2.5	-1.1	1.5	2.3	1.1	2.8
Pavlov. Cond. lever contacts	1.4	1.9	5.8	1.5	1.0	1.5	1.0	1.3	-1.2	1.6	-0.6	1.1	1.5	0.5	2.4
Pavlov. Cond. magazine entry number	2.1	2.6	5.5	-2.3	-1.4	-1.8	-1.3	-1.6	1.2	-2.0	0.8	-1.1	-1.8	-0.9	-2.3
Pavlov. Cond. intertrial magazine entries	2.7	3.6	5.6	-1.5	-1.9	-2.0	-1.9	-1.7	1.8	-2.0	2.1	-2.4	-1.3	-2.1	-1.7
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.8	7.7	2.5	1.7	2.2	1.7	2.0	-1.6	2.4	-1.1	1.5	2.2	1.1	2.8
Pavlov. Cond. response bias	1.5	2.0	6.4	1.8	1.1	1.5	1.0	1.4	-1.2	1.8	-0.5	1.0	1.6	0.5	2.5
Time in closed arm before self-admin	6.9	7.8	11.6	2.6	2.5	2.9	2.7	2.8	-2.6	3.1	-2.4	2.6	3.2	2.4	3.4
Time in closed arm after self-admin	0.3	0.3	0.6	-0.5	-0.5	-0.5	-0.5	-0.4	0.6	-0.6	0.7	-0.8	-0.0	-0.5	-0.1
Time in open arm before self-admin	0.3	0.3	1.3	-0.7	0.1	-0.3	-0.1	-0.4	0.4	-0.6	-0.2	-0.0	-0.9	-0.0	-1.1
Time in open arm after self-admin	0.3	0.4	1.3	-0.2	0.7	0.4	0.7	0.1	-0.6	0.4	-1.1	1.0	0.1	0.7	0.1
Bone: periosteal estimation	1.5	3.0	5.8	-2.4	-2.1	-1.8	-2.1	-1.9	1.6	-1.8	1.4	-0.8	-2.0	-1.2	-0.7
Bone: periosteal perimeter	3.6	5.9	9.9	-3.1	-2.6	-2.8	-2.8	-2.8	2.5	-2.6	2.0	-1.6	-2.6	-1.8	-1.3
Bone: post-yield work	0.2	0.3	0.9	-0.0	-0.6	-0.5	-0.7	-0.3	0.4	-0.4	1.0	-0.8	-0.3	-0.9	-0.0
Progressive ratio test 1 active lever presses	0.6	0.6	1.4	-0.1	-0.7	-0.9	-0.8	-0.5	0.6	-0.7	1.0	-1.2	-0.4	-1.2	-0.6
Progressive ratio test 1 breakpoint	0.4	0.4	1.0	-0.1	-0.5	-0.7	-0.6	-0.4	0.5	-0.6	0.7	-1.0	-0.4	-0.9	-0.8
Progressive ratio test 1 inactive lever presses	0.6	0.7	2.4	0.4	-0.6	-0.8	-0.8	-0.1	0.1	-0.1	1.2	-1.3	0.8	-1.6	0.6
Progressive ratio test 2 active lever presses	0.1	0.1	0.5	0.7	0.1	-0.1	-0.1	0.3	-0.2	-0.1	0.4	-0.6	-0.2	-0.3	-0.7
Progressive ratio test 2 breakpoint	0.2	0.2	0.6	0.6	-0.2	-0.3	-0.3	0.1	-0.0	-0.2	0.6	-0.8	-0.1	-0.5	-0.5
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.9	1.4	0.4	0.3	0.3	0.9	-1.0	0.7	0.2	-0.3	0.9	-0.1	0.3
Incentive Sensitization - Responses	0.2	0.2	0.9	1.0	0.4	0.3	0.3	0.7	-0.6	0.4	0.0	-0.0	0.4	-0.2	0.0
Incentive Sensitization - Breakpoint	0.1	0.1	0.7	0.8	0.2	0.1	0.1	0.5	-0.4	0.2	0.2	-0.3	0.2	-0.4	-0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.4	0.2	0.2	0.3	0.2	0.2	-0.2	0.4	-0.2	0.2	0.6	-0.1	0.6
Progressive ratio	0.2	0.3	0.8	0.5	0.3	0.6	0.3	0.5	-0.2	0.6	-0.2	0.3	0.9	0.2	0.9
Food seeking constrained by brief footshock	1.8	2.2	3.1	-1.3	-1.5	-1.7	-1.7	-1.8	1.2	-1.6	1.5	-1.5	-1.4	-1.3	-1.2
Seeking ratio, punishment vs. effort	1.0	1.2	1.6	-0.8	-1.0	-1.3	-1.1	-1.2	0.7	-1.2	1.0	-1.1	-1.2	-1.0	-1.1
Retroperitoneal fat weight	3.8	12.5	18.5	-3.6	-3.5	-3.9	-3.6	-4.0	4.3	-3.8	3.4	-3.6	-3.0	-3.2	-2.5
Reaction time number correct	0.9	1.3	2.9	0.5	1.2	1.1	1.3	1.0	-1.2	0.8	-1.7	1.5	-0.0	1.7	-0.3
Reaction time mean minus median	0.1	0.1	0.6	-0.8	-0.6	-0.4	-0.4	-0.4	0.3	-0.4	0.2	-0.1	-0.1	-0.1	-0.3
Reaction time mean minus median AUC	0.6	0.7	1.5	-1.2	-1.0	-1.0	-0.8	-1.1	1.0	-0.9	0.6	-0.8	-0.3	-0.6	-0.6
Reaction time num false alarms	0.1	0.2	0.6	-0.7	0.1	0.2	0.2	0.1	-0.7	-0.1	-0.5	0.6	-0.2	0.7	-0.2
Reaction time num false alarms AUC	0.2	0.3	1.0	-0.6	0.2	0.3	0.3	0.3	-0.9	-0.0	-0.7	0.8	-0.3	1.0	-0.4
Reaction time trials correct on left	0.9	1.3	2.9	0.5	1.2	1.1	1.3	1.0	-1.2	0.8	-1.7	1.5	-0.0	1.7	-0.3
Reaction time trials on left	1.0	1.4	3.2	0.5	1.3	1.1	1.3	1.1	-1.2	0.8	-1.7	1.6	-0.0	1.8	-0.3
Reaction time mean	0.2	0.2	0.7	0.3	0.2	0.4	0.3	0.4	-0.4	0.6	-0.4	0.4	0.8	0.5	0.8
Reaction time mean AUC	0.1	0.2	0.5	0.3	0.2	0.3	0.3	0.3	-0.4	0.5	-0.4	0.3	0.7	0.4	0.6
Median of all reaction times	0.4	0.5	1.1	0.7	0.5	0.6	0.5	0.7	-0.6	0.9	-0.6	0.5	1.0	0.7	1.1
Reaction time omissions	0.3	0.4	1.4	0.2	0.4	0.6	0.7	0.6	-1.0	0.3	-0.8	0.7	0.1	1.2	-0.3
Reaction time false alarm rate	0.1	0.1	0.5	-0.7	-0.4	-0.2	-0.3	-0.2	-0.2	-0.3	0.3	-0.2	-0.1	0.0	-0.1
Reaction time premature initiation rate	0.5	0.6	3.3	0.9	0.4	0.7	0.2	0.7	-0.4	1.0	0.0	0.5	0.9	-0.1	1.8
Reaction time premature initiations	0.5	0.7	1.8	1.0	0.7	0.9	0.6	0.9	-0.6	1.0	-0.6	0.9	0.7	0.6	1.3
Std. dev. reaction times	0.3	0.4	0.9	-1.0	-0.9	-0.7	-0.8	-0.7	0.4	-0.6	0.5	-0.5	-0.3	-0.4	-0.3
Reaction time trials completed	1.0	1.4	3.2	0.5	1.3	1.1	1.3	1.1	-1.2	0.8	-1.7	1.6	-0.0	1.8	-0.3
Reaction time trials AUC	0.7	1.1	2.5	0.4	1.1	1.0	1.1	0.9	-1.0	0.7	-1.5	1.4	-0.1	1.6	-0.3
Run reversals in cocaine runway, females	0.7	0.6	1.3	0.1	0.8	0.7	0.9	0.6	-1.0	0.4	-1.2	1.1	-0.2	1.1	-0.4
Run reversals in cocaine runway, males	1.3	1.2	3.8	-1.2	-1.0	-0.9	-0.9	-1.1	0.7	-1.3	0.4	-0.4	-1.9	-0.1	-2.0
Latency to leave start box in cocaine runway	0.1	0.2	0.4	-0.5	-0.3	-0.4	-0.3	-0.4	0.6	-0.4	0.3	-0.5	0.0	-0.4	-0.0
Latency to leave start box in cocaine runway, F	0.3	0.3	0.6	0.3	0.6	0.7	0.6	0.6	-0.4	0.6	-0.7	0.6	0.6	0.8	0.5
Latency to leave start box in cocaine runway, M	2.0	1.9	3.3	-1.1	-1.3	-1.5	-1.5	-1.4	1.7	-1.3	1.5	-1.8	-0.6	-1.8	-0.5
Std. dev. time between licks in bursts	1.4	1.7	2.6	1.6	1.3	1.3	1.1	1.5	-1.4	1.5	-0.8	1.1	1.2	0.8	1.6
Total sessions with >9 infusions	1.9	2.1	3.5	-0.7	-1.5	-1.7	-1.6	-1.3	1.4	-1.4	1.9	-1.8	-1.2	-1.7	-0.8
Short access day 1 total inactive lever presses	1.2	1.4	2.8	-0.6	-1.6	-1.3	-1.6	-1.1	0.7	-1.0	1.7	-1.3	-1.0	-1.3	-0.3
Short access day 10 total inactive lever presses	0.5	0.6	1.0	-0.8	-1.0	-0.8	-1.0	-0.9	0.7	-0.7	0.8	-0.5	-0.7	-0.6	-0.3
Short access day 1 total infusions	1.9	2.0	3.8	-0.7	-1.6	-1.7	-1.7	-1.2	0.8	-1.3	2.0	-1.8	-0.9	-1.8	-0.6
Short access day 10 total infusions	0.6	0.7	1.7	-0.3	-0.7	-0.9	-0.8	-0.7	1.1	-0.7	1.1	-1.3	-0.2	-1.0	-0.0
Short access total infusions	2.3	2.6	5.4	-0.6	-1.7	-1.9	-1.8	-1.4	1.3	-1.4	2.3	-2.3	-0.7	-2.0	-0.5
Short access day 1 locomotion	0.2	0.2	0.7	0.1	-0.4	-0.4	-0.4	-0.2	0.4	-0.2	0.8	-0.8	0.3	-0.4	0.3
Short access day 10 total locomotion	0.1	0.2	0.9	0.2	0.1	-0.2	-0.1	0.0	-0.3	0.3	0.1	-0.3	0.9	0.0	0.8
Short access total locomotion	1.1	1.2	2.9	-0.4	-1.0	-1.3	-1.2	-1.0	0.9	-0.9	1.5	-1.7	-0.2	-1.2	-0.0
One hour access (0.3 mA shock)	0.2	0.3	0.8	0.7	0.6	0.3	0.6	0.6	-0.9	0.4	-0.5	0.2	0.3	0.7	-0.2
Compulsive drug intake	1.9	1.9	3.1	1.4	1.4	1.6	1.5	1.5	-1.7	1.2	-1.4	1.5	0.3	1.7	-0.1
One hour access (shock baseline)	0.1	0.1	0.4	-0.3	-0.2	-0.6	-0.2	-0.3	0.4	-0.3	0.2	-0.6	0.2	-0.4	-0.0
Social response proportion	0.4	0.4	2.8	0.2	-0.4	-0.0	-0.2	0.0	0.2	0.4	0.5	-0.4	1.2	-0.6	1.7
Social responses	0.1	0.1	0.5	-0.0	0.2	0.3	0.2	0.2	-0.3	0.1	-0.3	0.5	-0.2	0.7	-0.1
Social time	1.8	2.4	3.2	1.8	1.8	1.6	1.7	1.7	-1.6	1.6	-1.4	1.2	1.6	1.4	1.0
Soleus weight	0.1	0.3	0.9	0.9	0.4	0.7	0.5	0.8	-0.8	0.4	-0.1	0.3	0.0	0.2	-0.2
Bone: stiffness	1.4	2.2	3.7	-1.0	-1.5	-1.7	-1.8	-1.6	1.7	-1.3	1.9	-1.7	-0.8	-1.7	-0.0
Tibialis anterior weight	0.7	2.3	3.6	1.9	1.4	1.7	1.6	1.8	-1.5	1.7	-1.1	1.0	1.8	1.3	1.2
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	-0.5	-0.2	0.1	-0.0	-0.1	0.2	-0.2	-0.1	0.4	-0.6	0.1	-0.3
Time to tail flick, vehicle, after self-admin	1.0	1.1	3.0	-0.1	1.0	1.1	1.1	0.7	-0.9	0.7	-1.6	1.7	0.0	1.6	0.0
Time to tail flick, test, before self-admin	0.4	0.4	1.7	-0.8	0.2	-0.2	-0.0	-0.4	0.3	-0.6	-0.3	0.1	-0.9	0.6	-1.3
Time to tail flick, test, after self-admin	1.1	1.2	2.0	0.9	1.4	1.1	1.2	1.1	-1.3	1.0	-1.2	1.2	0.8	1.0	0.6
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.6	0.4	0.4	0.4	0.3	0.3	-0.4	0.6	-0.4	0.3	0.7	0.6	0.8
Delta time to tail flick, test, before/after SA	2.7	2.5	3.7	1.6	1.4	1.6	1.5	1.8	-1.9	1.8	-1.4	1.6	1.5	1.0	1.5
Tibia length	0.9	2.6	3.8	-1.3	-1.6	-1.8	-1.9	-1.7	1.7	-1.6	1.6	-1.3	-1.9	-1.7	-1.1
Ambulatory time before self-admin	0.1	0.1	0.5	0.7	0.2	-0.1	0.0	0.3	-0.4	0.2	0.3	-0.6	0.6	-0.3	-0.1
Ambulatory time after self-admin	0.3	0.4	1.1	0.9	0.1	0.7	0.2	0.7	-1.1	0.6	-0.1	0.6	0.1	0.7	0.5
Bone: tissue strength	0.1	0.1	0.3	-0.2	-0.5	-0.4	-0.5	-0.4	0.4	-0.2	0.4	-0.1	-0.5	-0.3	0.2
Total heroin consumption	0.0	0.0	0.2	0.2	-0.1	0.0	-0.2	0.1	-0.0	-0.1	0.4	-0.3	-0.1	-0.4	-0.1
Bone: trabecular number	0.0	0.1	0.1	-0.4	0.1	-0.1	0.0	-0.3	0.2	-0.2	-0.3	0.1	-0.3	0.2	-0.3
Bone: trabecular spacing	1.1	1.4	2.1	-0.7	-1.1	-1.4	-1.3	-1.2	1.3	-1.2	1.5	-1.4	-1.0	-1.4	-0.6
Bone: trabecular thickness	0.3	0.4	0.8	0.3	0.5	0.6	0.4	0.6	-0.6	0.6	-0.5	0.5	0.9	0.6	0.9
Bone: trabecular tissue density	2.0	2.8	5.4	1.7	1.2	1.9	1.5	1.9	-1.6	2.0	-1.1	1.3	2.1	1.2	2.3
Water consumed over 24 hours	0.8	1.0	1.3	-0.8	-1.1	-0.9	-1.0	-1.0	1.0	-1.0	1.1	-0.8	-1.1	-1.0	-0.8
Number of responses in last shaping day	1.2	1.2	3.0	1.7	0.9	0.9	0.8	1.4	-1.1	1.2	-0.2	0.2	1.7	0.2	1.4