Hub : Genes

Pmm1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Pmm1 0.03 0.02 8.7e-03 0.01 0.01 0 0.01 5.4e-02 3.4e-02 8.1e-02 5.8e-02
2 NAcc gene expression Pmm1 0.16 0.08 0.0e+00 0.17 0.18 0.19 0.19 1.3e-25 4.2e-26 8.3e-28 7.5e-28
3 LHb gene expression Pmm1 0.33 0.15 8.3e-06 0.22 0.21 0.14 0.21 5.7e-06 1.1e-05 4.0e-04 1.1e-05
4 pVTA gene expression Pmm1 0.65 0.13 0.0e+00 0.5 0.49 0.52 0.47 1.1e-45 2.8e-44 1.7e-48 1.6e-42
5 IC gene expression Pmm1 0.22 0.1 5.4e-11 0.27 0.24 0.25 0.26 1.0e-11 1.1e-10 6.3e-11 1.7e-11
6 BLA gene expression Pmm1 0.32 0.12 5.6e-17 0.25 0.25 0.25 0.26 1.7e-13 1.6e-13 1.0e-13 2.9e-14
7 Brain gene expression Pmm1 0.37 0.11 0.0e+00 0.46 0.44 0.46 0.46 6.8e-47 5.6e-45 8.9e-47 8.8e-48
8 PL gene expression Pmm1 0.19 0.08 0.0e+00 0.24 0.23 0.23 0.24 2.1e-26 3.4e-25 7.8e-25 1.2e-25
9 Adipose gene expression Pmm1 0.1 0.04 3.7e-13 0.06 0.09 0.09 0.07 9.3e-08 3.3e-10 8.0e-10 9.5e-09
10 PL isoform ratio XM_063263321.1 0.03 0.02 7.4e-03 0 0.01 0.01 0.01 2.1e-01 7.8e-03 5.0e-02 9.5e-03
11 Brain mRNA stability Pmm1 0.03 0.02 1.0e-03 0 0.01 0.01 0.01 1.1e-01 4.8e-02 4.6e-02 7.0e-02
12 RMTg gene expression Pmm1 0.17 0.09 1.2e-04 0.04 0.13 0.04 0.1 4.2e-02 2.9e-04 2.4e-02 1.4e-03
13 IL gene expression Pmm1 0.23 0.12 8.9e-04 -0.01 0 -0 -0 9.6e-01 2.7e-01 4.5e-01 4.4e-01
14 OFC gene expression Pmm1 0.69 0.21 1.8e-07 0.16 0.26 0.34 0.24 1.1e-04 8.8e-07 7.7e-09 2.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.50.82.80.60.80.90.70.70.70.70.81.0-0.7-0.61.01.01.7
Area under the delay curve0.20.20.80.90.60.30.40.30.30.60.20.50.0-0.2-0.1-0.1-0.8
BMI with tail0.72.54.3-2.1-1.7-1.9-1.7-1.9-1.7-1.6-1.7-1.41.51.8-1.3-0.60.2
BMI without tail0.00.10.4-0.4-0.2-0.10.0-0.3-0.2-0.30.2-0.10.20.10.10.20.6
Body weight1.14.66.3-2.5-2.4-2.3-2.4-2.4-2.4-2.4-2.1-2.02.22.1-2.0-1.6-0.1
Weight adjusted by age0.20.32.10.1-0.40.10.20.1-0.1-0.60.1-0.60.50.2-0.4-1.0-1.4
Bone surface0.20.30.60.70.10.80.70.70.50.20.80.40.1-0.70.4-0.30.7
Bone volume0.10.10.70.20.10.40.30.30.20.10.40.3-0.0-0.30.30.00.8
Breakpoint value in progressive ratio session0.10.10.4-0.10.2-0.10.0-0.10.20.20.00.4-0.2-0.10.40.60.7
Number of licking bursts0.30.51.51.20.70.90.90.80.70.80.80.8-0.2-0.70.50.1-0.2
Context. condit. distance diff. score7.18.611.0-3.2-3.1-3.1-3.0-3.0-3.1-3.0-3.0-3.32.52.4-3.0-2.6-2.4
Locomotion velocity, session 10.40.42.30.4-0.60.20.10.1-0.5-0.6-0.0-0.40.9-0.3-0.6-1.5-0.8
Locomotion distance, session 11.92.45.62.41.42.01.91.91.51.31.91.3-1.0-1.91.10.1-0.5
Locomotion velocity, session 20.30.30.8-0.5-0.9-0.2-0.3-0.3-0.8-0.7-0.2-0.60.70.6-0.5-0.70.2
Locomotion distance, session 22.63.66.42.51.92.12.01.91.92.22.02.5-1.2-1.41.71.50.9
Locomotion velocity, session 30.40.41.6-0.4-0.6-0.4-0.4-0.2-0.3-0.9-0.3-1.00.5-0.1-0.7-1.3-0.9
Locomotion distance, session 30.91.02.31.41.01.21.01.11.00.41.00.3-0.8-1.50.4-0.4-1.0
Stereotopy head waving bouts, day 30.70.81.5-1.0-1.2-0.8-0.9-0.9-0.8-1.0-0.6-0.81.11.0-0.8-0.80.3
Stereotopy head waving duration, day 33.33.96.2-2.4-2.5-2.0-2.0-2.0-2.0-2.2-1.7-2.02.22.1-1.8-1.60.1
Locomotion velocity, session 70.20.20.6-0.2-0.4-0.5-0.5-0.5-0.3-0.7-0.4-0.60.3-0.1-0.6-0.8-0.3
Locomotion distance, session 70.10.10.40.70.7-0.10.0-0.10.40.4-0.00.5-0.3-0.1-0.10.2-0.3
Stereotopy head waving bouts, day 73.03.36.6-2.0-2.4-1.3-1.6-1.5-1.7-2.6-1.4-2.41.70.8-1.7-2.5-0.7
Stereotopy head waving duration, day 72.32.75.7-2.2-2.1-1.2-1.6-1.5-1.6-2.4-1.3-2.31.20.8-1.4-1.8-0.2
Locomotion velocity, session 82.42.95.0-1.5-2.0-1.6-1.5-1.3-2.0-1.5-1.6-1.52.21.8-1.8-1.8-1.4
Locomotion distance, session 80.91.32.3-1.2-1.3-1.1-1.0-0.8-1.3-1.0-1.1-1.41.00.9-1.2-1.1-1.5
Degree of sensitization distance1.71.83.9-1.8-1.2-1.8-1.6-1.8-1.3-0.7-1.6-0.71.02.0-0.90.20.3
Degree of sensitization stereotypy2.32.55.0-1.6-2.0-1.1-1.4-1.3-1.5-2.2-1.3-2.11.40.5-1.5-2.1-0.8
Conditioned locomotion0.80.91.6-0.9-0.8-0.8-0.9-1.0-1.1-1.1-1.0-1.30.80.6-1.1-1.0-1.0
Cocaine response after cond. corrected0.10.10.2-0.3-0.3-0.4-0.3-0.2-0.2-0.3-0.3-0.50.2-0.0-0.3-0.4-0.2
Cocaine response after cond. not corrected0.00.00.2-0.4-0.2-0.3-0.10.0-0.0-0.1-0.1-0.50.1-0.0-0.1-0.2-0.2
Cocaine response before conditioning0.20.20.50.10.50.50.60.60.50.60.70.2-0.4-0.20.50.6-0.0
Saline control response0.20.21.0-0.7-0.50.00.10.0-0.1-0.30.1-1.00.30.4-0.4-0.5-1.0
Bone: connectivity density0.20.32.00.40.30.50.30.30.30.30.40.6-0.3-0.30.50.51.4
Bone: cortical apparent density0.91.22.01.41.21.21.21.11.31.11.11.1-1.0-1.20.90.70.5
Bone: cortical area1.52.33.2-1.6-1.8-1.7-1.5-1.5-1.7-1.6-1.6-1.21.81.5-1.4-1.2-0.3
Bone: cortical porosity0.20.21.0-1.0-0.5-0.5-0.5-0.4-0.5-0.5-0.4-0.60.10.4-0.20.10.3
Bone: cortical porosity1.31.43.0-1.7-1.4-1.2-1.2-1.1-1.3-1.4-1.1-1.41.01.0-0.9-0.70.0
Bone: cortical thickness0.20.31.1-0.3-0.3-0.8-0.6-0.7-0.6-0.1-0.80.30.81.0-0.40.2-0.0
Bone: cortical thickness0.40.51.7-0.1-0.5-0.8-0.7-0.7-0.8-0.0-0.90.21.11.3-0.7-0.1-0.6
Bone: cortical tissue density0.81.11.91.41.21.21.11.11.21.11.11.1-0.9-1.10.90.60.4
Condit. Reinf. active minus inactive responses0.10.20.50.60.30.30.40.40.40.60.30.7-0.1-0.10.30.3-0.1
Condit. Reinf. active-inactive response ratio0.40.40.8-0.5-0.8-0.7-0.6-0.5-0.6-0.6-0.6-0.60.60.5-0.6-0.7-0.9
Condit. Reinf. active responses1.41.72.81.31.31.31.41.41.31.71.31.5-1.2-0.81.31.40.6
Condit. Reinf. inactive responses3.03.64.91.72.22.02.12.02.02.21.81.9-2.0-1.42.02.11.1
Incentive salience index mean0.50.61.41.00.80.70.80.70.71.20.71.2-0.4-0.20.60.80.1
Condit. Reinf. lever presses0.91.22.11.21.21.21.11.11.11.41.11.3-0.9-0.61.01.10.7
Condit. Reinf. active minus inactive responses0.10.10.50.5-0.2-0.3-0.1-0.3-0.10.3-0.30.70.60.4-0.2-0.1-0.4
Condit. Reinf. active-inactive response ratio0.10.20.50.2-0.3-0.4-0.4-0.5-0.20.1-0.40.70.60.4-0.10.00.5
Condit. Reinf. active responses0.60.92.0-0.3-1.1-1.0-0.8-0.9-0.9-0.6-0.9-0.31.41.0-1.0-1.1-1.1
Condit. Reinf. inactive responses1.21.53.5-0.7-1.2-1.2-0.9-0.9-1.1-1.0-1.0-1.11.51.2-1.5-1.5-1.9
Condit. Reinf. lever presses0.30.41.00.70.40.50.70.60.60.80.61.0-0.4-0.30.70.70.4
Condit. Reinf. lever reinforcers received0.30.41.0-0.1-0.8-0.7-0.5-0.6-0.6-0.3-0.70.01.00.8-0.6-0.6-0.6
Conditioned reinforcement - actives0.50.91.4-0.4-0.9-1.2-1.0-1.2-0.9-0.7-1.1-0.51.20.8-1.1-1.0-0.9
Conditioned reinforcement - inactives0.20.30.80.3-0.0-0.5-0.0-0.5-0.20.6-0.50.90.50.9-0.00.6-0.5
Conditioned locomotion1.41.82.8-1.2-1.3-1.7-1.6-1.7-1.4-0.9-1.7-0.71.71.4-1.3-0.70.2
Patch foraging indifference point 0 sec0.50.92.20.70.70.71.01.00.91.10.71.3-0.7-0.41.21.21.5
Patch foraging indifference point AUC0.30.41.61.30.50.60.60.80.60.40.50.50.1-0.5-0.0-0.6-1.1
Delay disc. indifference point, 0s delay0.70.81.9-1.4-0.6-1.1-1.0-1.0-0.9-0.5-1.1-0.90.61.3-0.7-0.2-0.3
Delay disc. indifference point, 16s delay1.01.12.41.61.31.01.01.01.11.21.11.2-0.8-1.10.80.5-0.1
Delay disc. indifference point, 2s delay0.10.20.90.20.2-0.3-0.2-0.3-0.1-0.0-0.4-0.10.50.4-0.6-0.3-1.0
Delay disc. indifference point, 24s delay0.40.41.51.20.30.40.10.30.30.10.20.20.6-0.9-0.5-1.2-1.1
Delay disc. indifference point, 4s delay0.10.10.30.4-0.0-0.00.10.0-0.10.5-0.20.50.50.6-0.10.1-0.5
Delay disc. indifference point, 8s delay0.60.71.81.41.10.90.80.80.81.00.70.9-0.6-0.70.40.5-0.1
Indifference point function ln k0.61.02.3-1.5-1.2-1.0-1.1-1.1-1.1-1.1-1.0-1.10.60.8-0.6-0.40.5
Indifference point function log k0.61.02.3-1.5-1.2-1.0-1.1-1.1-1.1-1.1-1.0-1.10.60.8-0.6-0.40.5
Patch foraging total patch changes 0 sec0.61.22.40.80.90.91.11.11.01.20.91.4-0.9-0.61.31.31.5
Patch foraging total patch changes 12 sec0.00.10.20.20.10.10.30.50.20.30.20.30.20.20.1-0.00.1
Patch foraging total patch changes 18 sec0.10.20.80.50.30.30.40.40.40.70.30.9-0.00.10.40.50.5
Patch foraging total patch changes 24 sec0.20.41.00.70.60.70.71.00.70.60.70.6-0.4-0.40.50.20.2
Patch foraging total patch changes 6 sec0.30.51.30.90.40.50.91.10.71.10.61.10.2-0.10.60.40.4
Patch foraging time to switch 0 sec0.10.32.1-0.40.30.10.10.30.20.10.2-0.1-0.8-0.30.50.71.4
Patch foraging water rate 0 sec0.10.20.60.40.10.30.50.10.20.40.50.80.10.10.50.50.3
Patch foraging water rate 12 sec0.20.51.00.50.40.80.70.50.50.30.70.6-0.8-1.00.90.50.9
Patch foraging water rate 18 sec1.21.82.41.31.11.51.51.31.41.21.51.4-1.0-1.61.50.91.4
Patch foraging water rate 24 sec0.10.21.2-0.4-0.6-0.0-0.1-0.5-0.3-0.2-0.10.20.10.20.30.21.1
Patch foraging water rate 6 sec0.60.92.01.10.61.41.20.90.90.51.40.7-0.8-1.41.00.30.2
Seeking ratio, delayed vs. immediate footshock3.84.66.02.22.22.02.01.92.12.22.02.3-2.2-2.22.22.12.5
Distance traveled before self-admin0.40.62.20.50.90.20.50.20.61.30.31.1-0.80.10.71.5-0.1
Distance traveled after self-admin0.10.21.00.50.00.00.30.00.00.40.11.00.40.20.40.60.3
Extensor digitorum longus weight0.20.71.00.30.60.90.90.90.80.70.80.5-1.0-0.81.00.90.9
Bone: elastic displacement0.20.20.7-0.3-0.50.0-0.2-0.2-0.3-0.7-0.2-0.70.5-0.3-0.3-0.8-0.0
Bone: elastic work2.22.84.4-2.1-2.0-1.7-1.8-1.8-1.8-1.9-1.7-1.61.81.5-1.4-1.3-0.0
Bone: endosteal estimation0.71.53.4-1.6-1.8-0.7-0.9-0.8-1.2-1.7-0.6-1.91.10.6-1.0-1.6-0.3
Bone: endosteal perimeter1.83.87.0-2.2-2.5-1.7-1.8-1.6-2.1-2.6-1.6-2.61.81.0-1.8-2.3-0.4
Epididymis fat weight2.06.910.6-3.3-2.6-2.9-3.0-2.9-2.8-2.7-2.8-2.82.12.7-2.6-1.7-1.2
Delta time in closed arm before/after self-admin0.40.41.9-0.0-0.2-0.6-0.4-0.7-0.3-0.1-0.6-0.10.80.7-0.7-0.3-1.4
Delta time in open arm before/after self-admin0.20.20.50.1-0.20.30.30.3-0.2-0.60.4-0.3-0.3-0.70.2-0.40.7
Diff in mean of infusions in LGA sessions0.20.20.70.1-0.3-0.3-0.3-0.4-0.3-0.2-0.20.00.80.4-0.5-0.5-0.8
Delay discount exponential model param0.20.31.0-1.0-0.6-0.4-0.4-0.4-0.4-0.6-0.3-0.5-0.10.20.10.10.9
Extinction: sum of active levers before priming0.70.81.1-1.0-0.9-1.0-1.0-0.9-0.8-0.6-1.0-0.81.01.0-0.9-0.6-0.5
Active lever presses in extinction session 60.10.10.4-0.6-0.4-0.4-0.3-0.5-0.3-0.4-0.2-0.40.40.1-0.3-0.1-0.0
Bone: final force1.11.83.0-1.3-1.5-1.6-1.5-1.5-1.4-1.2-1.4-0.81.71.7-1.2-0.8-0.0
Bone: final moment1.32.03.4-1.4-1.7-1.7-1.6-1.6-1.5-1.3-1.5-0.81.91.8-1.3-1.0-0.0
Food consumed during 24 hour testing period1.11.62.4-1.2-1.2-1.5-1.5-1.3-1.2-1.0-1.5-0.81.51.5-1.3-0.8-0.4
Glucose0.20.31.4-0.10.60.10.30.30.50.50.10.5-0.50.10.61.11.2
Heart weight7.111.114.5-3.8-3.8-3.7-3.3-3.6-3.7-3.3-3.5-3.03.73.5-3.1-2.2-1.6
Delay discount hyperbolic model param0.20.21.1-0.8-0.5-0.3-0.3-0.2-0.2-0.5-0.1-0.4-0.20.00.20.11.0
Intermittent access intake day 1-15 change0.20.50.90.50.80.80.60.30.70.90.50.7-0.9-0.30.81.00.7
Intermittent access intake escalation0.30.50.80.60.80.90.70.40.80.90.60.7-0.9-0.50.80.80.3
Intermittent access intake escalation 20.60.71.40.50.90.90.70.70.90.90.80.7-1.2-0.61.01.00.9
Intermitt. access day 1 inactive lever presses0.20.62.2-0.8-0.5-1.0-0.7-1.0-0.70.3-0.80.40.61.5-0.10.90.9
Intermitt. access day 15 inactive lever presses0.20.41.40.1-0.0-0.5-0.1-0.6-0.20.8-0.51.10.41.20.21.20.1
Intermitt. access escalation Index0.10.20.50.60.30.60.60.40.30.60.20.7-0.1-0.20.40.4-0.3
Intermittent access day 1 total infusions0.61.01.7-0.6-0.8-1.2-0.9-1.2-1.0-0.6-1.2-0.41.21.2-1.0-0.6-1.3
Intermittent access day 15 total infusions0.10.10.60.30.20.20.2-0.20.10.4-0.10.3-0.10.00.10.1-0.8
Intermittent access terminal intake (last 3 days)0.00.00.50.10.30.1-0.0-0.20.10.2-0.2-0.0-0.10.0-0.1-0.0-0.7
Intermittent access total infusions0.20.30.9-0.2-0.2-0.6-0.5-0.7-0.4-0.1-0.7-0.20.50.6-0.5-0.3-0.9
Intermittent access day 1 locomotion0.10.20.6-0.2-0.0-0.5-0.3-0.6-0.20.3-0.50.40.20.80.00.60.4
Intermittent access day 15 total locomotion0.10.10.4-0.4-0.2-0.4-0.5-0.6-0.3-0.1-0.5-0.00.20.7-0.10.10.4
Intermittent access total locomotion0.10.20.4-0.4-0.2-0.5-0.6-0.7-0.3-0.0-0.6-0.00.20.7-0.20.20.2
Intermittent access standard deviation0.20.51.2-1.1-0.2-0.7-0.8-0.9-0.4-0.0-0.9-0.2-0.11.0-0.10.80.8
Left kidney weight10.749.862.3-7.5-7.9-7.5-7.3-7.3-7.5-6.8-7.3-6.67.87.3-7.1-5.9-3.8
Right kidney weight11.452.163.9-7.9-8.0-7.9-7.8-7.6-7.8-6.7-7.7-6.57.87.9-7.1-5.4-3.4
Cocaine induced anxiety0.40.51.4-0.8-0.5-0.9-1.2-0.8-0.6-0.4-1.0-0.30.50.7-0.5-0.20.8
Post-drug Anxiety0.10.10.40.20.20.0-0.10.10.2-0.0-0.00.2-0.2-0.40.2-0.10.6
Baseline Anxiety1.01.22.31.51.11.31.51.31.20.61.30.7-0.9-1.20.80.2-0.7
Tail length0.41.53.11.01.11.51.41.51.20.81.60.5-1.2-1.81.20.40.2
Length with tail0.20.91.7-1.0-1.1-0.7-0.9-0.8-0.9-1.2-0.6-1.20.90.5-0.9-1.3-0.6
Length without tail1.85.77.6-2.7-2.7-2.7-2.8-2.5-2.6-2.4-2.6-2.12.32.5-2.2-1.8-0.2
Times rat made contact with spout0.80.92.8-0.3-0.7-0.9-0.8-0.8-0.8-0.4-0.9-0.41.41.2-1.1-0.9-1.7
Lifetime Intake0.70.81.7-0.5-0.6-1.2-1.0-1.3-0.9-0.3-1.2-0.21.11.3-0.9-0.3-1.1
Liver weight, left1.52.54.8-1.3-1.4-1.4-1.3-1.3-1.3-2.0-1.4-2.21.10.7-1.8-2.1-2.0
Liver weight, right2.34.18.6-2.4-2.0-1.9-1.9-1.8-1.9-2.5-1.8-2.91.41.4-2.1-2.1-1.6
Locomotor activity2.03.25.3-2.1-2.3-1.7-1.9-2.1-1.9-2.2-1.6-1.91.61.2-1.6-1.6-0.5
Locomotor testing distance0.10.10.20.30.20.30.20.20.40.10.40.3-0.4-0.40.30.30.4
Locomotor testing rearing1.22.43.0-1.6-1.7-1.6-1.6-1.5-1.7-1.6-1.5-1.71.51.4-1.6-1.3-1.2
Locomotion in novel chamber0.10.20.90.2-0.20.20.50.40.1-0.40.1-0.5-0.1-0.50.1-0.4-1.0
Locomotion in novel chamber post-restriction0.61.01.71.01.11.21.01.01.00.71.20.6-1.3-1.21.00.70.7
Fecal boli incidents, locomotor time 10.20.30.50.70.60.50.60.50.70.60.70.6-0.2-0.40.40.30.3
Change in fecal boli incidents, locomotor task1.41.34.3-0.3-1.2-0.5-1.0-0.8-1.2-1.4-1.0-1.11.40.3-1.4-2.1-1.1
Time >=10cm from walls, locomotor time 10.10.10.1-0.3-0.3-0.4-0.4-0.2-0.3-0.2-0.2-0.20.20.3-0.2-0.10.3
Bouts of movement, locomotor time 10.20.20.5-0.4-0.2-0.5-0.7-0.6-0.4-0.3-0.6-0.60.1-0.1-0.6-0.5-0.0
Total resting periods, locomotor time 10.10.10.3-0.10.2-0.3-0.5-0.4-0.00.2-0.5-0.0-0.10.0-0.30.00.3
Rest time, locomotor task time 10.30.41.0-0.5-0.1-0.9-1.0-0.8-0.40.1-1.0-0.10.51.0-0.70.2-0.2
Distance moved, locomotor task time 10.40.61.2-1.0-0.9-0.6-0.5-0.5-0.9-0.9-0.4-1.10.50.8-0.6-0.8-1.0
Vertical activity count, locomotor time 10.00.00.1-0.3-0.30.10.20.0-0.2-0.20.2-0.1-0.10.10.20.00.2
Time >=10cm from walls, locomotor time 20.10.10.30.50.50.40.40.30.40.20.40.3-0.2-0.40.30.20.5
Bouts of movement, locomotor time 20.10.21.0-0.3-0.2-0.6-0.6-1.0-0.5-0.1-0.70.00.30.5-0.40.20.1
Total resting periods, locomotor time 20.10.10.7-0.1-0.1-0.4-0.5-0.8-0.40.1-0.60.20.30.4-0.30.30.2
Rest time, locomotor task time 20.10.10.40.60.50.20.10.20.40.60.20.5-0.0-0.40.10.2-0.0
Distance moved, locomotor task time 20.91.01.6-1.2-0.9-1.0-0.8-0.9-1.1-1.1-0.9-1.30.81.1-0.9-0.8-1.1
Vertical activity count, locomotor time 20.20.30.8-0.7-0.6-0.4-0.3-0.6-0.6-0.9-0.4-0.70.40.6-0.4-0.4-0.2
Light reinforcement 10.10.30.8-0.3-0.9-0.3-0.1-0.1-0.4-0.6-0.3-0.60.7-0.2-0.4-0.9-0.4
Light reinforcement 20.50.81.3-1.2-0.8-1.0-1.1-0.8-0.7-0.9-1.2-1.10.70.9-1.0-0.7-0.5
Bone: marrow area0.81.63.6-1.7-1.9-0.8-1.0-0.8-1.2-1.7-0.7-1.91.20.7-1.1-1.6-0.3
Bone: maximum diameter3.87.211.0-2.8-3.3-2.8-2.7-2.6-3.1-2.9-2.7-2.53.12.5-2.5-2.4-0.7
Bone: maximum force1.93.35.3-1.8-2.0-2.2-2.0-1.9-1.9-1.6-1.9-1.22.32.2-1.8-1.2-0.5
Bone: maximum moment2.23.86.3-1.9-2.2-2.2-2.1-2.1-2.1-1.8-2.1-1.32.52.3-1.9-1.4-0.5
Mean time between licks in bursts0.30.81.40.71.20.80.90.81.01.00.60.8-1.0-0.90.91.00.5
Mean num. licks in bursts1.52.32.8-1.6-1.5-1.6-1.6-1.6-1.5-1.5-1.7-1.51.41.5-1.6-1.2-1.3
Cd content in liver1.82.14.1-0.6-1.3-1.2-1.3-1.4-1.4-1.3-1.5-1.11.90.9-1.8-1.8-2.0
Co content in liver0.10.10.50.40.1-0.2-0.0-0.1-0.20.4-0.10.60.70.4-0.20.1-0.5
Cu content in liver6.27.49.42.72.62.93.03.12.92.62.92.8-2.6-2.62.92.22.1
Fe content in liver0.60.81.8-1.3-1.3-0.7-0.7-0.6-0.9-1.0-0.7-0.70.80.9-0.4-0.31.2
K content in liver1.31.22.21.11.11.31.31.31.11.11.51.1-0.9-0.91.10.90.1
Mg content in liver1.31.42.21.21.31.11.11.31.21.41.21.5-0.9-0.81.21.20.5
Mn content in liver0.20.21.60.0-0.10.00.00.1-0.1-0.2-0.0-0.40.30.0-0.4-0.6-1.3
Na content in liver2.32.53.01.41.61.51.71.61.51.41.61.5-1.7-1.61.71.51.4
Rb content in liver0.10.20.80.0-0.4-0.4-0.2-0.2-0.3-0.0-0.30.20.90.6-0.4-0.4-0.5
Se content in liver0.40.51.00.60.60.90.70.80.70.30.90.4-0.8-1.00.60.20.5
Sr content in liver2.42.13.51.51.91.21.61.61.61.71.21.4-1.5-1.11.31.40.0
Zn content in liver0.10.10.30.4-0.00.20.20.30.0-0.20.20.00.2-0.4-0.1-0.5-0.5
Bone: minimum diameter0.51.01.9-1.2-1.4-1.0-0.9-0.8-1.1-1.4-0.9-1.20.90.5-0.8-1.1-0.0
Time in familiar zone, hab. session 10.30.31.10.4-0.2-0.4-0.3-0.2-0.2-0.4-0.4-0.30.80.1-0.7-1.1-0.8
Time in novel zone, hab. session 10.50.52.3-1.5-0.8-0.4-0.5-0.6-0.9-0.7-0.4-0.90.10.5-0.10.20.4
Total zone transitions, hab. session 12.73.77.32.71.92.52.32.22.01.62.31.5-1.6-2.31.50.5-0.3
Total locomotion distance, hab. session 11.21.73.81.61.01.81.71.71.30.71.70.4-1.1-2.00.9-0.3-0.5
Locomotion velocity, hab. session 11.62.23.91.91.22.01.91.91.61.11.90.8-1.3-1.91.10.1-0.2
Time in familiar zone, hab. session 20.10.10.7-0.20.1-0.3-0.20.1-0.2-0.4-0.3-0.8-0.2-0.4-0.3-0.6-0.4
Time in novel zone, hab. session 20.10.10.2-0.1-0.40.10.0-0.2-0.20.10.20.40.40.40.10.3-0.0
Total zone transitions, hab. session 20.81.02.71.70.71.41.21.30.91.11.21.2-0.1-0.60.60.2-0.6
Total locomotion distance, hab. session 20.70.91.61.30.71.21.11.20.91.01.11.1-0.5-0.80.80.60.1
Locomotion velocity, hab. session 21.31.72.81.71.11.61.51.61.31.41.51.4-0.8-1.11.20.80.2
Novel to familiar place preference ratio2.52.74.8-1.9-2.2-1.4-1.6-1.7-1.9-2.0-1.3-1.91.51.0-1.4-1.7-0.9
Novelty place preference3.53.86.1-2.2-2.5-1.7-1.9-2.0-2.2-2.4-1.6-2.31.81.2-1.8-2.0-1.3
Time in novel zone, NPP test4.54.87.6-2.4-2.8-1.9-2.1-2.3-2.5-2.6-1.9-2.52.11.4-2.0-2.3-1.5
Total zone transitions, NPP test2.33.37.22.71.72.42.22.31.71.62.21.6-1.1-2.11.30.3-0.5
Total locomotion distance, NPP test1.21.73.31.81.11.81.51.61.21.21.61.3-0.8-1.41.10.40.3
Locomotion velocity, NPP test2.02.84.82.21.62.21.92.01.81.62.01.5-1.4-1.81.50.80.4
Intraocular pressure0.50.71.4-0.4-0.6-0.9-0.8-0.9-0.8-0.9-0.8-0.90.60.4-0.9-1.1-1.2
Delta distance traveled before/after self-admin1.31.43.1-0.6-1.6-0.8-0.8-0.8-1.3-1.7-0.8-0.91.80.5-1.2-1.7-1.0
Delta ambulatory time before/after self-admin1.51.84.2-0.6-1.8-0.9-0.8-0.8-1.4-1.8-0.9-1.02.10.8-1.3-2.0-1.5
Parametrial fat weight0.00.10.5-0.20.30.1-0.0-0.00.1-0.30.0-0.7-0.4-0.3-0.2-0.3-0.5
Pavlov. Cond. lever latency0.70.91.5-0.9-1.0-0.9-0.9-0.8-0.9-1.2-1.1-1.00.90.4-0.9-1.1-0.7
Pavlov. Cond. magazine entry latency0.70.92.21.21.40.70.90.80.91.50.91.3-0.7-0.30.71.10.1
Pavlov. Cond. change in total contacts1.31.33.11.61.41.01.11.01.21.71.01.8-0.5-0.20.91.20.4
Pavlov. Cond. index score0.50.71.71.01.10.60.60.50.71.30.71.2-0.50.10.61.10.4
Pavlov. Cond. latency score0.50.61.60.81.00.60.70.50.71.30.81.1-0.60.10.61.10.5
Pavlov. Cond. lever contacts1.92.33.71.51.71.51.51.31.61.91.61.7-1.5-0.81.51.70.9
Pavlov. Cond. magazine entry number0.81.02.3-1.4-1.5-0.7-0.9-0.7-1.0-1.5-0.9-1.40.70.2-0.7-1.1-0.0
Pavlov. Cond. intertrial magazine entries0.91.11.71.10.81.21.11.01.01.01.11.3-0.8-1.01.21.01.0
Pavlov. Cond. lever-magazine prob. diff.0.70.82.01.11.20.70.80.60.91.40.81.2-0.6-0.10.61.00.2
Pavlov. Cond. response bias1.11.42.91.41.61.01.00.91.31.71.11.5-1.0-0.40.91.40.5
Pavlov. Cond. lever latency1.11.43.5-0.7-0.7-1.1-1.1-1.0-1.1-1.3-1.1-1.51.00.6-1.5-1.5-1.9
Pavlov. Cond. magazine entry latency4.04.98.82.12.02.12.02.02.12.51.93.0-2.0-1.52.52.52.4
Pavlov. Cond. change in total contacts0.81.25.20.60.40.60.60.70.71.30.51.9-0.30.11.31.62.3
Pavlov. Cond. index score2.33.15.81.51.41.61.61.51.72.01.52.4-1.5-1.02.12.22.2
Pavlov. Cond. latency score3.03.97.21.81.71.81.81.81.92.31.82.7-1.7-1.22.32.32.2
Pavlov. Cond. lever contacts1.31.84.00.90.91.21.31.21.21.41.31.6-1.1-0.71.71.62.0
Pavlov. Cond. magazine entry number2.42.95.7-1.6-1.3-1.6-1.4-1.4-1.5-1.8-1.4-2.41.51.2-2.0-1.9-2.3
Pavlov. Cond. intertrial magazine entries2.23.45.8-1.6-1.4-2.3-1.9-1.9-1.8-1.3-1.9-1.42.12.4-2.1-1.2-2.0
Pavlov. Cond. lever-magazine prob. diff.2.63.45.91.51.51.71.71.61.72.01.62.4-1.7-1.12.22.22.3
Pavlov. Cond. response bias1.52.05.51.10.91.21.21.11.21.51.11.9-1.1-0.71.71.72.3
Time in closed arm before self-admin5.77.39.52.12.72.92.82.92.92.62.92.3-3.0-2.33.12.82.6
Time in closed arm after self-admin0.10.11.00.10.40.20.10.20.30.20.2-0.1-0.20.3-0.00.3-1.0
Time in open arm before self-admin0.10.10.40.0-0.00.0-0.10.0-0.1-0.2-0.1-0.3-0.1-0.2-0.3-0.5-0.6
Time in open arm after self-admin0.20.21.10.1-0.10.30.20.3-0.1-0.60.4-0.3-0.4-0.90.2-0.61.1
Bone: periosteal estimation1.32.75.0-2.0-2.2-1.4-1.5-1.4-1.7-2.1-1.4-2.01.81.2-1.5-1.8-0.2
Bone: periosteal perimeter3.96.69.9-2.9-3.1-2.6-2.6-2.4-2.8-3.2-2.5-2.92.51.8-2.5-2.6-0.7
Bone: post-yield work0.30.41.3-0.1-0.5-0.7-0.6-0.6-0.6-0.2-0.60.11.10.8-0.7-0.4-0.6
Progressive ratio test 1 active lever presses0.20.20.7-0.0-0.1-0.5-0.4-0.6-0.40.2-0.60.20.50.7-0.5-0.1-0.9
Progressive ratio test 1 breakpoint0.10.20.60.1-0.0-0.4-0.3-0.5-0.20.2-0.50.20.40.5-0.4-0.1-0.8
Progressive ratio test 1 inactive lever presses0.50.72.9-0.5-0.2-1.2-0.7-1.2-0.50.5-1.10.70.51.7-0.21.1-0.0
Progressive ratio test 2 active lever presses0.20.21.30.3-0.0-0.5-0.3-0.5-0.20.2-0.60.40.60.5-0.4-0.2-1.1
Progressive ratio test 2 breakpoint0.20.21.30.40.1-0.4-0.3-0.4-0.10.3-0.50.40.50.4-0.4-0.2-1.2
Progressive ratio test 2 inactive lever presses0.40.61.60.80.90.40.70.30.71.30.41.2-0.8-0.10.71.2-0.1
Incentive Sensitization - Responses0.10.11.20.50.3-0.10.20.00.20.3-0.00.50.20.1-0.0-0.0-1.1
Incentive Sensitization - Breakpoint0.10.11.10.40.2-0.30.0-0.10.10.3-0.20.40.30.3-0.2-0.1-1.1
Sum of active levers in priming session hrs 5-60.00.00.2-0.3-0.1-0.1-0.1-0.0-0.1-0.1-0.1-0.2-0.1-0.10.10.00.4
Progressive ratio0.20.40.90.00.50.40.40.60.60.80.50.5-0.7-0.20.71.00.9
Food seeking constrained by brief footshock1.72.12.9-1.2-1.6-1.5-1.6-1.7-1.6-1.6-1.6-1.11.61.1-1.5-1.3-0.6
Seeking ratio, punishment vs. effort0.81.21.9-0.6-1.1-1.0-1.2-1.4-1.2-1.2-1.2-0.71.40.8-1.3-1.2-0.7
Retroperitoneal fat weight3.715.820.5-4.5-4.1-4.3-4.5-4.3-4.2-4.0-4.2-4.13.74.0-4.0-3.2-1.9
Reaction time number correct0.51.03.21.30.91.31.01.11.00.41.20.4-1.1-1.80.8-0.10.2
Reaction time mean minus median0.10.20.7-0.8-0.6-0.3-0.3-0.3-0.6-0.4-0.3-0.80.10.3-0.3-0.1-0.4
Reaction time mean minus median AUC0.40.92.0-1.4-1.0-0.9-1.0-0.9-1.2-0.9-1.0-1.30.40.8-0.8-0.4-0.7
Reaction time num false alarms0.10.10.4-0.3-0.0-0.00.30.30.2-0.30.2-0.6-0.1-0.4-0.0-0.3-0.1
Reaction time num false alarms AUC0.10.10.3-0.1-0.00.10.40.50.2-0.10.3-0.6-0.1-0.50.0-0.4-0.4
Reaction time trials correct on left0.51.03.21.30.91.31.01.11.00.41.20.4-1.1-1.80.8-0.10.2
Reaction time trials on left0.61.13.41.30.91.31.11.21.00.41.20.4-1.1-1.80.8-0.10.1
Reaction time mean0.20.20.7-0.00.20.40.40.40.30.50.20.3-0.8-0.40.70.80.6
Reaction time mean AUC0.10.20.50.10.20.40.30.30.20.40.20.3-0.7-0.30.60.70.5
Median of all reaction times0.40.61.10.40.50.70.60.70.60.70.50.7-1.0-0.61.01.01.0
Reaction time omissions0.10.10.30.30.10.40.50.30.0-0.00.3-0.2-0.3-0.50.1-0.2-0.5
Reaction time false alarm rate0.10.20.6-0.8-0.3-0.6-0.2-0.2-0.2-0.2-0.4-0.70.40.4-0.3-0.1-0.4
Reaction time premature initiation rate0.40.62.20.40.30.30.50.80.61.00.61.2-0.20.00.91.01.5
Reaction time premature initiations0.40.71.70.80.50.70.71.00.80.90.91.1-0.5-0.50.90.71.3
Std. dev. reaction times0.30.51.2-1.1-1.0-0.6-0.6-0.6-1.0-0.7-0.8-1.00.40.6-0.5-0.3-0.5
Reaction time trials completed0.61.13.41.30.91.31.11.21.00.41.20.4-1.1-1.80.8-0.10.1
Reaction time trials AUC0.40.82.81.10.71.20.91.00.90.31.10.3-1.0-1.70.7-0.10.3
Run reversals in cocaine runway, females0.20.20.60.60.50.80.70.70.40.00.7-0.0-0.3-0.60.2-0.2-0.2
Run reversals in cocaine runway, males1.81.84.4-0.7-1.5-0.8-0.9-1.1-1.4-1.8-0.9-1.51.30.3-1.5-2.1-2.0
Latency to leave start box in cocaine runway0.10.10.4-0.6-0.1-0.4-0.4-0.0-0.10.1-0.2-0.4-0.20.1-0.10.20.6
Latency to leave start box in cocaine runway, F0.20.31.20.20.40.30.30.60.50.40.60.2-0.5-0.70.40.41.1
Latency to leave start box in cocaine runway, M0.70.61.4-1.2-0.6-1.0-1.0-0.8-0.7-0.4-1.0-0.80.41.0-0.7-0.2-0.3
Std. dev. time between licks in bursts1.41.93.21.41.11.51.51.21.31.41.31.8-0.9-1.11.51.31.6
Total sessions with >9 infusions4.15.09.2-1.8-2.0-2.7-2.4-2.8-2.2-1.3-2.6-1.12.93.0-2.3-1.1-1.8
Short access day 1 total inactive lever presses1.21.53.9-1.0-1.5-1.4-1.1-1.5-1.5-0.5-1.3-0.01.92.0-0.9-0.2-0.1
Short access day 10 total inactive lever presses0.51.22.0-1.2-1.3-1.1-1.1-1.4-1.3-1.2-1.2-1.10.91.0-1.0-0.7-0.0
Short access day 1 total infusions1.72.25.1-1.3-1.5-1.9-1.3-1.8-1.6-0.7-1.6-0.52.02.3-1.3-0.4-1.1
Short access day 10 total infusions0.81.12.3-1.0-0.7-1.4-1.2-1.5-0.9-0.4-1.3-0.51.11.5-1.0-0.1-0.7
Short access total infusions2.22.86.4-1.3-1.4-2.2-1.7-2.2-1.7-0.7-2.0-0.42.22.5-1.6-0.5-1.3
Short access day 1 locomotion0.40.51.7-0.9-0.4-0.9-0.7-0.8-0.6-0.0-0.8-0.20.71.3-0.40.4-0.2
Short access day 10 total locomotion0.30.62.6-0.10.8-0.10.2-0.10.41.20.10.7-0.80.10.71.61.1
Short access total locomotion0.60.72.0-1.0-0.4-1.2-1.0-1.2-0.70.2-1.1-0.10.81.4-0.50.50.2
One hour access (0.3 mA shock)0.20.20.50.40.60.20.2-0.00.40.50.00.5-0.7-0.30.40.70.5
Compulsive drug intake0.20.21.51.20.00.20.30.10.10.00.20.70.6-0.2-0.2-0.6-0.4
One hour access (shock baseline)0.20.21.0-0.30.60.10.10.00.30.5-0.00.1-1.0-0.10.61.00.5
Social response proportion0.30.31.6-0.7-0.2-0.0-0.2-0.3-0.20.2-0.20.2-0.20.60.41.11.3
Social responses0.10.10.20.3-0.10.30.40.30.10.00.5-0.10.1-0.30.0-0.3-0.4
Social time1.82.44.11.71.81.61.61.71.62.01.51.7-1.4-1.31.51.50.3
Soleus weight0.10.20.90.90.40.30.50.50.50.70.40.80.50.10.0-0.0-0.2
Bone: stiffness1.01.72.6-1.4-1.4-1.6-1.4-1.4-1.5-1.1-1.4-0.81.51.6-1.1-0.60.1
Tibialis anterior weight0.82.73.51.61.81.51.71.51.81.91.61.9-1.5-1.51.71.80.8
Time to tail flick, vehicle, before self-admin0.00.00.1-0.3-0.2-0.00.10.0-0.00.10.2-0.20.30.0-0.0-0.2-0.0
Time to tail flick, vehicle, after self-admin0.50.72.60.70.41.11.11.10.60.01.20.1-0.8-1.60.8-0.1-0.0
Time to tail flick, test, before self-admin0.90.93.0-0.7-0.7-0.9-0.9-0.7-0.7-1.1-0.9-1.20.70.5-1.1-1.1-1.7
Time to tail flick, test, after self-admin0.10.10.40.40.40.40.50.50.30.10.30.1-0.4-0.30.20.0-0.7
Delta time to tail flick, vehicle, before/after SA0.00.00.2-0.2-0.3-0.1-0.1-0.2-0.3-0.4-0.2-0.0-0.0-0.30.1-0.0-0.0
Delta time to tail flick, test, before/after SA2.02.13.11.51.31.61.81.51.41.41.61.5-1.4-1.01.61.31.1
Tibia length0.92.54.2-1.1-1.8-1.6-1.6-1.6-1.6-1.5-1.6-1.22.11.4-1.7-1.9-0.8
Ambulatory time before self-admin0.20.31.00.50.70.10.60.10.40.90.20.8-0.50.10.51.0-0.7
Ambulatory time after self-admin0.50.61.51.20.40.91.10.90.60.60.91.2-0.1-0.80.80.40.1
Bone: tissue strength0.20.20.6-0.4-0.7-0.4-0.5-0.5-0.5-0.8-0.4-0.40.60.0-0.4-0.7-0.0
Total heroin consumption0.30.41.7-0.1-0.5-0.7-0.4-0.7-0.4-0.2-0.5-0.11.00.7-0.7-0.5-1.3
Bone: trabecular number0.00.10.30.10.10.2-0.00.00.1-0.30.1-0.1-0.2-0.40.0-0.20.6
Bone: trabecular spacing1.31.72.5-1.0-1.4-1.5-1.5-1.6-1.4-1.1-1.5-0.81.61.5-1.4-1.0-0.8
Bone: trabecular thickness0.50.61.20.10.80.80.70.70.60.70.70.5-1.1-0.51.01.10.9
Bone: trabecular tissue density2.74.06.21.31.82.02.02.01.92.12.22.0-2.0-1.32.32.52.3
Water consumed over 24 hours0.40.61.5-0.5-0.8-0.7-0.6-0.5-0.7-0.5-0.7-0.51.21.0-0.9-0.8-1.0
Number of responses in last shaping day1.61.86.20.71.40.81.00.61.22.10.71.9-1.00.41.32.51.2