Hub : Genes

Pm20d2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	intron excision ratio	chr5_52375967_52379875	0.03	0.02	1.3e-03	0.01	0.01	0.01	0.01	1.0e-02	1.3e-02	2.0e-02	3.1e-02
2	Adipose	gene expression	Pm20d2	0.02	0.02	2.0e-03	0.01	0.01	0.01	0.01	1.6e-02	2.9e-02	4.4e-02	3.9e-02
3	Adipose	intron excision ratio	chr5_52375967_52379879	0.02	0.02	1.3e-03	0.01	0.01	0	0.01	1.2e-02	1.6e-02	8.9e-02	3.5e-02
4	Eye	isoform ratio	XM_063287585.1	0.4	0.18	7.3e-03	0.02	-0.02	-0.02	-0.02	1.7e-01	8.6e-01	9.0e-01	6.7e-01
5	NAcc	gene expression	Pm20d2	0.01	0.01	5.9e-03	0.02	0.01	0.01	0.01	1.6e-04	1.8e-02	9.4e-03	2.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.1	0.1	0.2	0.3	0.3	-0.3	0.4	0.4
Area under the delay curve	0.2	0.2	0.6	0.0	0.0	-0.0	-0.7	-0.7
BMI with tail	4.5	15.7	16.1	3.9	3.9	-3.9	4.0	4.0
BMI without tail	5.2	15.9	16.1	4.0	4.0	-4.0	4.0	3.9
Body weight	6.9	30.4	30.8	5.5	5.5	-5.5	5.5	5.4
Weight adjusted by age	0.1	0.1	0.2	0.3	0.3	-0.3	-0.4	-0.4
Bone surface	0.3	0.5	0.6	0.7	0.7	-0.7	0.8	0.7
Bone volume	0.1	0.2	0.2	0.4	0.4	-0.4	0.4	0.3
Breakpoint value in progressive ratio session	0.9	1.1	1.3	1.2	1.2	-1.2	0.8	1.0
Number of licking bursts	0.5	0.8	0.8	-0.9	-0.9	0.9	-0.9	-0.9
Context. condit. distance diff. score	0.9	1.1	1.2	-1.0	-1.0	1.0	-1.1	-1.0
Locomotion velocity, session 1	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.0	0.0
Locomotion distance, session 1	1.3	1.7	1.8	-1.3	-1.3	1.3	-1.2	-1.2
Locomotion velocity, session 2	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	0.1
Locomotion distance, session 2	2.3	3.3	3.5	-1.9	-1.9	1.9	-1.7	-1.7
Locomotion velocity, session 3	1.6	1.8	1.9	-1.3	-1.3	1.3	-1.4	-1.3
Locomotion distance, session 3	2.8	3.0	3.7	-1.6	-1.6	1.6	-1.9	-1.9
Stereotopy head waving bouts, day 3	0.4	0.5	0.8	0.6	0.6	-0.6	0.7	0.9
Stereotopy head waving duration, day 3	0.9	1.1	1.6	0.9	0.9	-0.9	1.1	1.3
Locomotion velocity, session 7	0.0	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.2
Locomotion distance, session 7	0.6	0.8	0.9	-0.8	-0.8	0.8	-1.0	-1.0
Stereotopy head waving bouts, day 7	0.2	0.3	0.4	0.5	0.5	-0.5	0.5	0.6
Stereotopy head waving duration, day 7	1.4	1.7	1.9	1.3	1.3	-1.3	1.3	1.4
Locomotion velocity, session 8	2.1	2.6	3.0	-1.7	-1.7	1.7	-1.4	-1.4
Locomotion distance, session 8	4.9	7.1	7.5	-2.6	-2.6	2.6	-2.7	-2.7
Degree of sensitization distance	1.0	1.0	1.4	0.9	0.9	-0.9	1.2	1.2
Degree of sensitization stereotypy	0.2	0.3	0.3	0.5	0.5	-0.5	0.4	0.5
Conditioned locomotion	0.1	0.1	0.2	0.1	0.1	-0.1	0.3	0.4
Cocaine response after cond. corrected	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	0.3
Cocaine response after cond. not corrected	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.2	-0.3
Cocaine response before conditioning	0.3	0.3	0.5	-0.5	-0.5	0.5	-0.6	-0.7
Saline control response	0.1	0.2	0.3	0.5	0.5	-0.5	0.3	0.3
Bone: connectivity density	0.2	0.3	0.5	0.4	0.4	-0.4	0.7	0.7
Bone: cortical apparent density	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.3	-0.3
Bone: cortical area	2.3	3.6	3.8	1.9	1.9	-1.9	2.0	1.9
Bone: cortical porosity	0.1	0.1	0.2	-0.2	-0.2	0.2	-0.5	-0.4
Bone: cortical porosity	0.2	0.2	0.2	0.5	0.5	-0.5	0.3	0.3
Bone: cortical thickness	0.4	0.7	0.7	0.8	0.8	-0.8	0.9	0.7
Bone: cortical thickness	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.2	-0.3
Bone: cortical tissue density	0.1	0.1	0.2	-0.3	-0.3	0.3	-0.3	-0.4
Condit. Reinf. active minus inactive responses	1.7	1.9	2.4	-1.3	-1.3	1.3	-1.5	-1.5
Condit. Reinf. active-inactive response ratio	1.9	2.1	2.6	-1.4	-1.4	1.4	-1.5	-1.6
Condit. Reinf. active responses	0.7	0.8	1.0	-0.9	-0.9	0.9	-1.0	-1.0
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	0.3
Incentive salience index mean	0.3	0.4	0.6	-0.6	-0.6	0.6	-0.7	-0.8
Condit. Reinf. lever presses	0.3	0.4	0.5	0.7	0.7	-0.7	0.6	0.6
Condit. Reinf. active minus inactive responses	0.0	0.1	0.1	-0.2	-0.2	0.2	-0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.3	-0.3
Condit. Reinf. active responses	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	-0.1
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.0	0.0	-0.0	0.1	0.2
Condit. Reinf. lever presses	0.1	0.2	0.2	0.4	0.4	-0.4	0.4	0.4
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	0.2	0.2	-0.2	0.1	0.1
Conditioned reinforcement - actives	0.4	0.7	1.0	1.0	1.0	-1.0	0.7	0.6
Conditioned reinforcement - inactives	1.0	1.5	1.6	1.3	1.3	-1.3	1.1	1.2
Conditioned locomotion	1.6	2.0	2.5	1.6	1.6	-1.6	1.1	1.2
Patch foraging indifference point 0 sec	0.1	0.2	0.4	0.2	0.2	-0.2	0.6	0.6
Patch foraging indifference point AUC	0.8	1.1	1.3	1.1	1.1	-1.1	0.9	0.9
Delay disc. indifference point, 0s delay	1.3	1.5	2.0	-1.1	-1.1	1.1	-1.4	-1.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.3	0.3	-0.3	-0.1	-0.1
Delay disc. indifference point, 2s delay	0.7	0.8	1.7	-0.4	-0.4	0.4	-1.3	-1.3
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.1	-0.1	0.1	-0.4	-0.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	0.2	0.2	-0.2	-0.4	-0.4
Delay disc. indifference point, 8s delay	0.3	0.4	0.9	-0.0	-0.0	0.0	-1.0	-1.0
Indifference point function ln k	0.0	0.0	0.0	-0.2	-0.2	0.2	0.0	0.0
Indifference point function log k	0.0	0.0	0.0	-0.2	-0.2	0.2	0.0	0.0
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.0	-0.0	0.0	0.2	0.3
Patch foraging total patch changes 12 sec	1.5	2.0	2.3	1.5	1.5	-1.5	1.2	1.3
Patch foraging total patch changes 18 sec	0.1	0.2	0.4	-0.3	-0.3	0.3	-0.6	-0.6
Patch foraging total patch changes 24 sec	0.6	1.0	1.2	1.1	1.1	-1.1	0.8	0.8
Patch foraging total patch changes 6 sec	0.4	0.6	0.9	0.8	0.8	-0.8	0.8	0.9
Patch foraging time to switch 0 sec	0.5	1.1	1.2	-1.1	-1.1	1.1	-1.0	-1.0
Patch foraging water rate 0 sec	0.9	1.8	2.0	1.4	1.4	-1.4	1.2	1.3
Patch foraging water rate 12 sec	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.3	-0.3
Patch foraging water rate 18 sec	0.1	0.1	0.1	-0.4	-0.4	0.4	-0.2	-0.2
Patch foraging water rate 24 sec	0.1	0.1	0.1	0.3	0.3	-0.3	0.2	0.3
Patch foraging water rate 6 sec	0.2	0.3	0.3	0.6	0.6	-0.6	0.6	0.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.4	0.4	-0.4	-0.2	-0.2
Distance traveled before self-admin	0.2	0.3	0.7	-0.3	-0.3	0.3	-0.8	-0.7
Distance traveled after self-admin	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1	0.1
Extensor digitorum longus weight	4.6	18.1	18.4	4.2	4.2	-4.2	4.3	4.3
Bone: elastic displacement	0.1	0.2	0.2	0.4	0.4	-0.4	0.4	0.5
Bone: elastic work	4.7	6.2	6.5	2.5	2.5	-2.5	2.4	2.4
Bone: endosteal estimation	3.0	6.5	7.1	2.7	2.7	-2.7	2.3	2.4
Bone: endosteal perimeter	2.6	5.5	5.7	2.4	2.4	-2.4	2.2	2.4
Epididymis fat weight	0.0	0.1	0.1	-0.3	-0.3	0.3	-0.0	-0.1
Delta time in closed arm before/after self-admin	2.5	2.3	2.4	-1.6	-1.6	1.6	-1.5	-1.4
Delta time in open arm before/after self-admin	0.8	0.8	1.2	1.1	1.1	-1.1	0.3	0.4
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.1	0.1	-0.1	-0.5	-0.3
Delay discount exponential model param	0.1	0.2	0.4	-0.1	-0.1	0.1	0.6	0.6
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.1	0.1	-0.1	-0.5	-0.3
Active lever presses in extinction session 6	0.3	0.3	0.5	-0.4	-0.4	0.4	-0.7	-0.6
Bone: final force	1.4	2.3	2.5	1.5	1.5	-1.5	1.6	1.5
Bone: final moment	2.5	4.0	4.1	2.0	2.0	-2.0	2.0	1.9
Food consumed during 24 hour testing period	1.1	1.6	1.7	1.3	1.3	-1.3	1.2	1.2
Glucose	0.1	0.1	0.3	0.2	0.2	-0.2	0.4	0.6
Heart weight	0.5	0.8	1.0	0.8	0.8	-0.8	1.0	0.9
Delay discount hyperbolic model param	0.2	0.2	0.5	-0.2	-0.2	0.2	0.7	0.7
Intermittent access intake day 1-15 change	1.5	3.1	3.6	-1.7	-1.7	1.7	-1.8	-1.9
Intermittent access intake escalation	1.3	2.8	3.2	-1.6	-1.6	1.6	-1.8	-1.6
Intermittent access intake escalation 2	1.6	1.8	3.3	-1.0	-1.0	1.0	-1.8	-1.7
Intermitt. access day 1 inactive lever presses	0.1	0.6	0.7	-0.8	-0.8	0.8	-0.7	-0.5
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	0.0	0.0	-0.0	-0.2	0.1
Intermitt. access escalation Index	0.1	0.2	0.2	0.4	0.4	-0.4	0.5	0.4
Intermittent access day 1 total infusions	2.0	3.2	3.3	1.8	1.8	-1.8	1.7	1.7
Intermittent access day 15 total infusions	0.1	0.2	0.3	0.3	0.3	-0.3	0.4	0.6
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.0	0.1
Intermittent access total infusions	1.9	2.3	3.3	1.3	1.3	-1.3	1.6	1.8
Intermittent access day 1 locomotion	1.8	2.3	2.4	1.5	1.5	-1.5	1.6	1.5
Intermittent access day 15 total locomotion	0.4	0.8	0.8	0.9	0.9	-0.9	0.8	0.9
Intermittent access total locomotion	1.0	1.2	1.4	1.2	1.2	-1.2	0.8	1.0
Intermittent access standard deviation	0.2	0.4	0.9	-0.3	-0.3	0.3	-0.8	-0.9
Left kidney weight	0.9	4.2	4.8	2.2	2.2	-2.2	1.8	1.8
Right kidney weight	0.8	3.6	3.8	1.9	1.9	-1.9	2.0	1.9
Cocaine induced anxiety	0.9	1.3	1.8	-1.3	-1.3	1.3	-0.7	-0.7
Post-drug Anxiety	0.2	0.2	0.3	-0.6	-0.6	0.6	0.2	0.2
Baseline Anxiety	0.8	0.9	1.2	0.9	0.9	-0.9	1.0	1.1
Tail length	1.6	6.1	7.2	2.4	2.4	-2.4	2.7	2.4
Length with tail	2.4	10.6	11.4	3.4	3.4	-3.4	3.2	2.9
Length without tail	1.0	3.1	3.3	1.8	1.8	-1.8	1.7	1.7
Times rat made contact with spout	0.1	0.1	0.2	-0.0	-0.0	0.0	-0.4	-0.5
Lifetime Intake	2.1	2.5	3.7	1.4	1.4	-1.4	1.8	1.9
Liver weight, left	0.8	1.3	1.5	1.2	1.2	-1.2	1.0	1.0
Liver weight, right	0.9	1.5	1.8	1.2	1.2	-1.2	1.3	1.3
Locomotor activity	0.3	0.5	0.6	-0.8	-0.8	0.8	-0.4	-0.5
Locomotor testing distance	0.1	0.3	0.3	-0.5	-0.5	0.5	-0.4	-0.5
Locomotor testing rearing	1.0	2.1	2.5	-1.4	-1.4	1.4	-1.6	-1.6
Locomotion in novel chamber	0.3	0.3	0.5	0.5	0.5	-0.5	0.7	0.6
Locomotion in novel chamber post-restriction	0.6	0.9	1.4	1.2	1.2	-1.2	0.5	0.4
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.3	-0.1
Change in fecal boli incidents, locomotor task	0.4	0.4	0.6	0.8	0.8	-0.8	0.0	-0.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.0	-0.0	0.0	-0.4	-0.3
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.2	-0.2	0.2	-0.3	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.4	-0.2
Rest time, locomotor task time 1	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	0.1
Distance moved, locomotor task time 1	0.0	0.0	0.0	-0.2	-0.2	0.2	-0.1	-0.2
Vertical activity count, locomotor time 1	0.2	0.4	0.4	-0.6	-0.6	0.6	-0.5	-0.6
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.1	0.1	-0.1	0.2	0.3
Bouts of movement, locomotor time 2	0.7	1.1	1.9	0.8	0.8	-0.8	1.4	1.4
Total resting periods, locomotor time 2	0.6	1.1	1.8	0.8	0.8	-0.8	1.3	1.3
Rest time, locomotor task time 2	0.3	0.4	0.6	0.5	0.5	-0.5	0.7	0.8
Distance moved, locomotor task time 2	0.2	0.2	0.2	-0.5	-0.5	0.5	-0.4	-0.4
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0	0.1
Light reinforcement 1	1.4	3.4	3.5	1.9	1.9	-1.9	1.8	1.8
Light reinforcement 2	0.6	1.0	1.6	0.8	0.8	-0.8	1.3	1.2
Bone: marrow area	2.9	6.4	7.0	2.6	2.6	-2.6	2.3	2.4
Bone: maximum diameter	2.7	5.0	5.0	2.2	2.2	-2.2	2.2	2.2
Bone: maximum force	2.6	4.7	4.7	2.2	2.2	-2.2	2.2	2.1
Bone: maximum moment	3.6	6.3	6.5	2.6	2.6	-2.6	2.5	2.4
Mean time between licks in bursts	0.4	1.1	1.3	1.2	1.2	-1.2	0.8	0.9
Mean num. licks in bursts	0.4	0.6	0.8	0.9	0.9	-0.9	0.6	0.5
Cd content in liver	2.4	2.6	3.2	1.8	1.8	-1.8	1.3	1.4
Co content in liver	0.0	0.1	0.1	-0.2	-0.2	0.2	-0.3	-0.3
Cu content in liver	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.2	-0.1
Fe content in liver	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.1	0.1
K content in liver	0.7	0.7	0.7	-0.9	-0.9	0.9	-0.8	-0.8
Mg content in liver	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.3	-0.3
Mn content in liver	0.2	0.2	0.3	0.5	0.5	-0.5	0.5	0.5
Na content in liver	2.7	2.9	3.3	-1.8	-1.8	1.8	-1.5	-1.5
Rb content in liver	2.2	2.6	3.1	-1.8	-1.8	1.8	-1.4	-1.3
Se content in liver	4.3	5.1	5.1	-2.3	-2.3	2.3	-2.3	-2.3
Sr content in liver	1.5	1.3	1.5	-1.1	-1.1	1.1	-1.2	-1.2
Zn content in liver	0.0	0.0	0.0	-0.0	-0.0	0.0	0.1	0.1
Bone: minimum diameter	1.7	3.0	3.2	1.8	1.8	-1.8	1.6	1.7
Time in familiar zone, hab. session 1	1.8	1.7	2.1	1.3	1.3	-1.3	1.3	1.4
Time in novel zone, hab. session 1	6.8	6.8	7.7	-2.6	-2.6	2.6	-2.6	-2.8
Total zone transitions, hab. session 1	4.9	6.8	7.6	-2.8	-2.8	2.8	-2.4	-2.4
Total locomotion distance, hab. session 1	4.4	6.2	6.6	-2.6	-2.6	2.6	-2.3	-2.4
Locomotion velocity, hab. session 1	2.7	3.8	4.2	-2.0	-2.0	2.0	-1.8	-1.8
Time in familiar zone, hab. session 2	0.9	0.9	1.2	0.9	0.9	-0.9	1.0	1.1
Time in novel zone, hab. session 2	0.4	0.5	0.7	-0.6	-0.6	0.6	-0.7	-0.8
Total zone transitions, hab. session 2	1.6	2.0	2.4	-1.5	-1.5	1.5	-1.2	-1.2
Total locomotion distance, hab. session 2	0.6	0.8	1.0	-1.0	-1.0	1.0	-0.7	-0.8
Locomotion velocity, hab. session 2	0.6	0.8	1.0	-1.0	-1.0	1.0	-0.7	-0.7
Novel to familiar place preference ratio	0.2	0.2	0.3	-0.6	-0.6	0.6	-0.2	-0.2
Novelty place preference	0.8	0.9	1.1	-1.0	-1.0	1.0	-0.7	-0.7
Time in novel zone, NPP test	1.1	1.2	1.5	-1.2	-1.2	1.2	-0.9	-0.9
Total zone transitions, NPP test	2.6	3.8	4.5	-2.1	-2.1	2.1	-1.7	-1.6
Total locomotion distance, NPP test	0.6	0.8	1.0	-1.0	-1.0	1.0	-0.6	-0.6
Locomotion velocity, NPP test	0.2	0.3	0.4	-0.6	-0.6	0.6	-0.2	-0.2
Intraocular pressure	6.4	9.2	11.0	3.3	3.3	-3.3	2.5	2.6
Delta distance traveled before/after self-admin	0.4	0.4	0.9	0.4	0.4	-0.4	0.9	0.9
Delta ambulatory time before/after self-admin	0.4	0.4	1.0	0.4	0.4	-0.4	1.0	0.9
Parametrial fat weight	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.1	-0.3
Pavlov. Cond. lever latency	2.3	2.8	3.1	-1.7	-1.7	1.7	-1.8	-1.7
Pavlov. Cond. magazine entry latency	1.6	2.1	2.3	1.5	1.5	-1.5	1.3	1.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	-0.1
Pavlov. Cond. index score	1.9	2.4	2.5	1.6	1.6	-1.6	1.5	1.5
Pavlov. Cond. latency score	2.4	3.0	3.1	1.8	1.8	-1.8	1.7	1.7
Pavlov. Cond. lever contacts	2.4	2.9	3.1	1.7	1.7	-1.7	1.8	1.7
Pavlov. Cond. magazine entry number	2.0	2.6	2.9	-1.7	-1.7	1.7	-1.4	-1.4
Pavlov. Cond. intertrial magazine entries	3.4	4.0	4.3	-2.0	-2.0	2.0	-2.0	-2.1
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	1.9	1.4	1.4	-1.4	1.3	1.2
Pavlov. Cond. response bias	1.8	2.2	2.5	1.6	1.6	-1.6	1.4	1.4
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.1	0.1	-0.1	0.2	0.2
Pavlov. Cond. magazine entry latency	0.8	0.9	1.0	-1.0	-1.0	1.0	-0.9	-0.9
Pavlov. Cond. change in total contacts	0.0	0.1	0.1	-0.0	-0.0	0.0	-0.3	-0.4
Pavlov. Cond. index score	0.3	0.3	0.4	-0.5	-0.5	0.5	-0.7	-0.6
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.2	-0.2
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.3	-0.3
Pavlov. Cond. magazine entry number	0.5	0.7	0.7	0.9	0.9	-0.9	0.7	0.7
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.4	-0.6	-0.6	0.6	-0.7	-0.6
Pavlov. Cond. response bias	0.4	0.6	0.6	-0.8	-0.8	0.8	-0.7	-0.7
Time in closed arm before self-admin	1.5	2.0	2.2	1.4	1.4	-1.4	1.5	1.4
Time in closed arm after self-admin	0.1	0.1	0.2	-0.1	-0.1	0.1	-0.4	-0.4
Time in open arm before self-admin	0.9	1.0	1.1	-1.1	-1.1	1.1	-0.9	-1.0
Time in open arm after self-admin	0.2	0.2	0.2	0.5	0.5	-0.5	0.3	0.4
Bone: periosteal estimation	3.7	7.8	8.3	2.9	2.9	-2.9	2.6	2.7
Bone: periosteal perimeter	5.0	8.6	8.7	2.9	2.9	-2.9	2.9	2.9
Bone: post-yield work	0.3	0.4	0.5	0.6	0.6	-0.6	0.6	0.7
Progressive ratio test 1 active lever presses	2.3	2.8	3.7	1.5	1.5	-1.5	1.9	1.9
Progressive ratio test 1 breakpoint	2.3	2.8	3.6	1.5	1.5	-1.5	1.9	1.9
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.1	0.1	-0.1	-0.3	0.0
Progressive ratio test 2 active lever presses	0.5	0.6	0.9	0.7	0.7	-0.7	0.8	0.9
Progressive ratio test 2 breakpoint	0.5	0.6	1.0	0.6	0.6	-0.6	0.8	1.0
Progressive ratio test 2 inactive lever presses	0.7	1.2	1.4	1.2	1.2	-1.2	0.8	1.0
Incentive Sensitization - Responses	0.1	0.1	0.2	0.4	0.4	-0.4	0.3	0.4
Incentive Sensitization - Breakpoint	0.1	0.2	0.2	0.4	0.4	-0.4	0.4	0.4
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	0.5	0.5	-0.5	0.5	0.7
Progressive ratio	0.9	1.3	2.0	1.0	1.0	-1.0	1.4	1.4
Food seeking constrained by brief footshock	1.4	1.7	2.1	1.4	1.4	-1.4	1.1	1.0
Seeking ratio, punishment vs. effort	0.5	0.7	1.4	-0.4	-0.4	0.4	-1.2	-1.2
Retroperitoneal fat weight	0.9	3.9	4.1	-2.0	-2.0	2.0	-1.8	-1.9
Reaction time number correct	0.1	0.1	0.2	0.3	0.3	-0.3	0.4	0.5
Reaction time mean minus median	0.0	0.1	0.2	-0.4	-0.4	0.4	-0.1	-0.1
Reaction time mean minus median AUC	0.2	0.4	0.6	-0.8	-0.8	0.8	-0.5	-0.4
Reaction time num false alarms	0.9	1.3	1.4	1.1	1.1	-1.1	1.1	1.2
Reaction time num false alarms AUC	0.8	1.3	1.4	1.1	1.1	-1.1	1.2	1.2
Reaction time trials correct on left	0.1	0.1	0.2	0.3	0.3	-0.3	0.4	0.5
Reaction time trials on left	0.1	0.2	0.3	0.3	0.3	-0.3	0.5	0.5
Reaction time mean	0.6	1.0	1.7	0.8	0.8	-0.8	1.2	1.3
Reaction time mean AUC	0.4	0.6	1.0	0.6	0.6	-0.6	1.0	1.0
Median of all reaction times	1.2	1.7	2.6	1.1	1.1	-1.1	1.6	1.6
Reaction time omissions	0.6	0.8	1.2	0.7	0.7	-0.7	1.1	1.1
Reaction time false alarm rate	0.4	0.6	0.6	0.8	0.8	-0.8	0.7	0.7
Reaction time premature initiation rate	0.2	0.3	0.8	0.3	0.3	-0.3	0.9	0.7
Reaction time premature initiations	0.5	0.9	1.6	0.7	0.7	-0.7	1.2	1.1
Std. dev. reaction times	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.1	-0.1
Reaction time trials completed	0.1	0.2	0.3	0.3	0.3	-0.3	0.5	0.5
Reaction time trials AUC	0.1	0.1	0.3	0.3	0.3	-0.3	0.5	0.5
Run reversals in cocaine runway, females	0.3	0.3	0.4	0.6	0.6	-0.6	0.5	0.5
Run reversals in cocaine runway, males	0.2	0.2	0.2	-0.5	-0.5	0.5	-0.4	-0.1
Latency to leave start box in cocaine runway	0.3	0.4	0.6	0.8	0.8	-0.8	0.3	0.2
Latency to leave start box in cocaine runway, F	0.3	0.3	0.4	0.7	0.7	-0.7	0.3	0.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.5	-0.0	-0.0	0.0	-0.4	-0.7
Std. dev. time between licks in bursts	0.2	0.3	0.3	0.6	0.6	-0.6	0.5	0.5
Total sessions with >9 infusions	2.3	2.8	4.2	1.4	1.4	-1.4	2.1	2.0
Short access day 1 total inactive lever presses	0.7	0.9	1.6	0.7	0.7	-0.7	1.2	1.2
Short access day 10 total inactive lever presses	1.9	4.5	5.0	-2.2	-2.2	2.2	-2.0	-1.9
Short access day 1 total infusions	0.3	0.4	1.2	0.3	0.3	-0.3	1.1	0.9
Short access day 10 total infusions	0.7	0.9	1.6	0.7	0.7	-0.7	1.2	1.3
Short access total infusions	1.9	2.4	3.9	1.2	1.2	-1.2	2.0	1.9
Short access day 1 locomotion	0.2	0.3	0.4	0.4	0.4	-0.4	0.6	0.6
Short access day 10 total locomotion	0.6	1.2	1.9	0.9	0.9	-0.9	1.2	1.4
Short access total locomotion	2.0	2.5	4.1	1.2	1.2	-1.2	2.0	2.0
One hour access (0.3 mA shock)	0.1	0.2	0.3	0.5	0.5	-0.5	0.2	0.1
Compulsive drug intake	0.1	0.1	0.4	-0.0	-0.0	0.0	-0.6	-0.6
One hour access (shock baseline)	0.3	0.5	1.0	0.4	0.4	-0.4	1.0	1.0
Social response proportion	2.4	2.7	3.0	-1.7	-1.7	1.7	-1.6	-1.5
Social responses	1.3	1.6	1.9	-1.2	-1.2	1.2	-1.4	-1.4
Social time	0.7	0.9	2.2	-0.5	-0.5	0.5	-1.3	-1.5
Soleus weight	1.6	4.6	5.4	2.3	2.3	-2.3	1.9	1.9
Bone: stiffness	0.0	0.0	0.0	0.2	0.2	-0.2	0.0	0.0
Tibialis anterior weight	6.4	21.8	22.3	4.7	4.7	-4.7	4.6	4.6
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.2	-0.4	-0.4	0.4	-0.3	-0.4
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.2	-0.3
Time to tail flick, test, before self-admin	2.3	2.4	3.1	1.4	1.4	-1.4	1.6	1.8
Time to tail flick, test, after self-admin	0.9	0.9	1.3	0.9	0.9	-0.9	1.1	0.9
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.2	-0.2	0.2	-0.3	-0.3
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.3	-0.5
Tibia length	1.6	4.3	5.1	2.3	2.3	-2.3	1.7	1.9
Ambulatory time before self-admin	0.4	0.6	1.1	-0.6	-0.6	0.6	-1.1	-0.9
Ambulatory time after self-admin	0.4	0.4	0.8	0.5	0.5	-0.5	0.9	0.8
Bone: tissue strength	0.4	0.4	0.4	-0.6	-0.6	0.6	-0.7	-0.6
Total heroin consumption	1.6	1.9	2.0	1.4	1.4	-1.4	1.2	1.4
Bone: trabecular number	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.3	-0.3
Bone: trabecular spacing	0.8	1.0	1.2	1.0	1.0	-1.0	1.1	1.1
Bone: trabecular thickness	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.1
Bone: trabecular tissue density	5.1	7.5	8.1	-2.7	-2.7	2.7	-2.8	-2.7
Water consumed over 24 hours	0.5	0.7	1.0	1.0	1.0	-1.0	0.6	0.6
Number of responses in last shaping day	1.1	1.2	1.9	1.0	1.0	-1.0	1.4	1.1