Hub : Genes

Plxnc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Plxnc1 0.09 0.07 4.1e-03 0.08 0.01 0.05 0.06 7.2e-05 8.6e-02 1.4e-03 4.0e-04
2 NAcc isoform ratio XM_039080099.1 0.02 0.01 5.0e-03 0.01 0.01 0 0 6.6e-02 2.5e-02 2.2e-01 1.6e-01
3 PL mRNA stability Plxnc1 0.04 0.03 6.9e-04 0.03 0.02 0.01 0.01 4.5e-04 5.8e-03 5.3e-02 8.0e-03
4 pVTA gene expression Plxnc1 0.1 0.06 6.8e-04 0.02 0.03 0.06 0 5.8e-02 1.5e-02 1.3e-03 1.9e-01
5 NAcc gene expression Plxnc1 0.08 0.04 4.8e-10 0.09 0.09 0.1 0.11 6.5e-11 5.8e-11 1.8e-11 3.1e-12
6 Brain gene expression Plxnc1 0.04 0.02 1.3e-04 0.02 0.04 0.03 0.03 1.1e-02 1.2e-04 3.5e-04 2.2e-03
7 Brain isoform ratio XM_039080099.1 0.06 0.03 2.6e-03 0.04 0.03 0.02 0.04 6.3e-05 5.2e-04 4.0e-03 2.1e-04
8 LHb gene expression Plxnc1 0.41 0.13 6.9e-06 0.13 0.22 0.14 0.18 5.3e-04 6.1e-06 4.3e-04 5.0e-05
9 NAcc isoform ratio XM_039080100.1 0.02 0.02 7.9e-03 -0 -0 -0 -0 6.0e-01 4.9e-01 4.2e-01 6.9e-01
10 Adipose gene expression Plxnc1 0.04 0.02 1.1e-03 0.04 0.02 0.02 0.03 1.6e-05 3.9e-03 9.4e-04 9.3e-05
11 BLA gene expression Plxnc1 0.22 0.11 5.9e-08 0.15 0.14 0.13 0.14 2.8e-08 1.0e-07 2.0e-07 7.6e-08
12 PL gene expression Plxnc1 0.04 0.03 4.8e-03 0.01 0.02 0.02 0.02 1.1e-02 3.6e-03 1.8e-03 2.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.20.41.5-0.6-0.1-0.00.7-0.0-0.0-0.6-0.50.91.20.40.7
Area under the delay curve1.01.04.1-1.3-0.3-0.3-0.50.50.60.7-0.0-1.3-1.4-2.0-1.2
BMI with tail0.92.812.0-1.22.2-2.5-0.3-1.5-1.41.9-0.30.7-3.5-0.5-0.3
BMI without tail2.55.112.4-2.53.5-3.51.8-2.8-2.6-0.8-2.01.6-2.00.90.4
Body weight8.033.665.8-7.88.1-8.15.9-6.9-6.4-3.6-5.44.1-4.23.21.5
Weight adjusted by age0.30.42.0-1.4-0.00.60.2-0.2-0.40.3-0.30.40.50.41.1
Bone surface0.10.21.0-0.60.6-1.00.0-0.5-0.4-0.1-0.60.3-0.40.00.1
Bone volume0.10.20.6-0.70.5-0.80.2-0.4-0.4-0.1-0.70.4-0.00.20.5
Breakpoint value in progressive ratio session1.92.14.11.5-1.81.5-1.31.51.52.01.5-1.3-0.3-1.6-0.3
Number of licking bursts0.30.40.90.00.6-0.70.3-0.6-0.50.9-0.10.9-0.90.10.8
Context. condit. distance diff. score0.40.51.8-0.70.7-0.70.4-0.4-0.2-1.3-0.20.8-0.60.0-1.1
Locomotion velocity, session 10.80.92.00.6-1.41.4-0.60.80.71.40.6-0.31.2-0.40.5
Locomotion distance, session 10.20.20.7-0.8-0.50.30.40.20.20.80.3-0.3-0.4-0.30.4
Locomotion velocity, session 20.30.42.6-0.0-0.40.70.50.30.4-1.60.20.10.50.1-0.6
Locomotion distance, session 20.40.52.5-1.60.3-0.70.9-0.4-0.40.4-0.2-0.5-1.0-0.00.7
Locomotion velocity, session 30.50.62.1-0.7-0.70.90.50.60.6-1.50.1-0.11.1-0.0-0.8
Locomotion distance, session 30.40.43.0-1.70.3-0.30.8-0.1-0.1-0.50.0-0.3-0.9-0.2-0.4
Stereotopy head waving bouts, day 30.60.73.6-0.0-0.90.91.20.70.7-1.00.00.21.9-0.00.2
Stereotopy head waving duration, day 30.50.64.20.5-0.70.90.40.50.5-1.0-0.20.22.1-0.1-0.0
Locomotion velocity, session 70.10.10.5-0.7-0.30.30.20.10.10.30.6-0.50.00.20.5
Locomotion distance, session 70.20.31.6-0.6-0.50.4-0.20.40.40.30.5-1.3-0.7-0.2-0.1
Stereotopy head waving bouts, day 70.80.93.0-1.0-0.20.60.9-0.1-0.2-0.9-0.31.41.70.81.2
Stereotopy head waving duration, day 70.30.42.2-0.5-0.30.70.30.10.0-0.0-0.10.81.50.30.9
Locomotion velocity, session 80.30.42.20.30.4-0.20.4-0.3-0.3-1.0-0.50.11.50.5-0.7
Locomotion distance, session 81.42.18.6-2.91.6-1.91.6-1.3-1.2-1.0-0.90.6-1.50.2-0.2
Degree of sensitization distance0.50.51.61.2-0.60.4-1.20.50.50.70.5-1.1-0.0-0.4-0.3
Degree of sensitization stereotypy0.40.41.6-0.2-0.61.0-0.10.30.4-0.50.40.91.30.20.4
Conditioned locomotion0.10.20.70.3-0.20.10.00.10.4-0.80.4-0.1-0.9-0.1-0.3
Cocaine response after cond. corrected0.20.30.90.00.9-0.8-0.2-0.6-0.5-0.3-1.0-0.2-0.4-0.1-0.1
Cocaine response after cond. not corrected0.30.41.3-0.11.0-0.9-0.0-0.7-0.7-0.0-1.1-0.1-0.2-0.1-0.2
Cocaine response before conditioning0.10.10.60.3-0.10.1-0.00.0-0.20.80.00.20.80.2-0.1
Saline control response0.91.11.6-1.31.1-1.20.6-1.3-1.1-1.1-1.11.1-0.21.30.9
Bone: connectivity density0.30.52.90.2-0.40.50.60.20.3-1.1-0.30.71.70.50.3
Bone: cortical apparent density0.30.41.5-1.20.5-0.61.1-0.7-0.4-0.6-0.00.5-0.60.3-0.1
Bone: cortical area0.91.34.0-1.71.4-2.01.2-1.1-1.20.3-1.50.4-0.80.10.3
Bone: cortical porosity0.30.31.4-0.00.2-0.20.2-0.1-0.1-1.2-0.8-0.81.10.20.2
Bone: cortical porosity0.20.31.0-0.40.4-0.50.2-0.2-0.3-0.5-0.9-1.00.50.10.3
Bone: cortical thickness0.81.33.7-1.91.1-1.51.5-0.9-1.2-0.4-1.70.20.50.60.7
Bone: cortical thickness0.20.30.90.4-0.60.5-0.20.60.50.40.1-0.90.8-0.40.1
Bone: cortical tissue density0.30.41.2-1.10.5-0.51.0-0.6-0.4-0.70.00.4-0.50.3-0.1
Condit. Reinf. active minus inactive responses1.82.08.01.4-1.61.8-1.71.40.82.81.0-1.10.7-0.30.7
Condit. Reinf. active-inactive response ratio1.81.97.31.4-1.51.5-2.01.40.92.71.0-0.90.4-0.60.4
Condit. Reinf. active responses2.12.68.41.7-2.02.2-1.61.61.02.91.1-1.40.9-0.31.0
Condit. Reinf. inactive responses0.81.02.11.3-1.41.5-0.61.00.91.10.8-1.30.5-0.30.5
Incentive salience index mean1.01.28.00.3-1.01.1-0.50.6-0.02.80.1-0.60.60.51.8
Condit. Reinf. lever presses0.60.83.6-1.1-0.20.21.1-0.2-0.51.4-0.50.00.20.81.9
Condit. Reinf. active minus inactive responses0.91.12.61.0-1.31.3-1.01.00.81.61.1-1.10.5-0.20.9
Condit. Reinf. active-inactive response ratio0.20.20.80.3-0.50.6-0.30.30.20.50.1-0.30.70.10.9
Condit. Reinf. active responses0.91.33.41.3-1.21.3-1.31.00.81.81.5-1.20.2-0.20.3
Condit. Reinf. inactive responses1.51.93.61.9-1.21.3-1.81.31.21.71.7-1.50.1-0.8-1.0
Condit. Reinf. lever presses0.20.30.90.2-0.80.7-0.20.40.50.50.9-0.60.00.50.8
Condit. Reinf. lever reinforcers received1.11.54.01.3-1.31.4-1.41.10.92.01.7-1.40.1-0.40.2
Conditioned reinforcement - actives1.81.82.6-1.61.3-1.21.2-1.5-1.5-0.6-1.51.6-0.11.31.6
Conditioned reinforcement - inactives1.82.03.8-1.91.3-1.61.9-1.4-1.4-1.0-1.51.3-0.61.01.4
Conditioned locomotion1.92.23.6-1.71.6-1.91.8-1.8-1.6-1.4-1.51.1-0.51.51.1
Patch foraging indifference point 0 sec0.30.51.8-1.20.4-0.01.1-0.1-0.2-1.3-0.60.90.30.40.5
Patch foraging indifference point AUC0.91.02.3-1.00.8-0.81.5-0.8-0.9-0.9-1.11.10.61.21.1
Delay disc. indifference point, 0s delay0.40.41.8-1.3-0.50.70.60.40.30.40.1-0.10.8-0.90.3
Delay disc. indifference point, 16s delay1.61.76.5-0.9-0.1-1.0-0.30.30.60.90.2-1.2-2.6-2.4-1.7
Delay disc. indifference point, 2s delay0.20.32.2-1.50.3-0.40.2-0.4-0.30.2-0.40.10.1-0.4-0.1
Delay disc. indifference point, 24s delay0.80.82.5-0.30.4-1.00.6-0.10.2-0.5-0.6-1.0-1.0-1.5-1.6
Delay disc. indifference point, 4s delay0.20.20.6-0.70.1-0.3-0.7-0.1-0.10.3-0.4-0.7-0.2-0.5-0.3
Delay disc. indifference point, 8s delay1.11.24.5-0.8-0.60.2-0.80.91.00.10.2-1.3-1.3-2.1-1.6
Indifference point function ln k0.40.51.60.7-0.30.2-0.80.50.60.50.9-0.7-0.8-0.9-1.3
Indifference point function log k0.40.51.60.7-0.30.2-0.80.50.60.50.9-0.7-0.8-0.9-1.3
Patch foraging total patch changes 0 sec0.30.41.5-1.10.4-0.00.9-0.1-0.2-1.2-0.60.70.20.30.5
Patch foraging total patch changes 12 sec2.12.77.6-1.71.3-1.11.9-1.3-1.7-0.1-1.91.80.81.82.8
Patch foraging total patch changes 18 sec2.53.27.3-1.91.6-1.12.4-1.6-1.6-1.6-1.62.70.72.01.8
Patch foraging total patch changes 24 sec2.12.64.0-1.51.7-1.52.0-1.6-1.7-1.2-1.81.80.41.61.7
Patch foraging total patch changes 6 sec0.20.30.9-0.10.5-0.30.6-0.3-0.4-0.2-0.61.00.10.50.9
Patch foraging time to switch 0 sec0.00.00.1-0.10.0-0.0-0.1-0.1-0.1-0.2-0.10.3-0.00.10.1
Patch foraging water rate 0 sec1.11.73.2-1.81.6-1.81.2-1.3-1.50.9-1.00.8-1.70.30.7
Patch foraging water rate 12 sec2.03.05.3-1.62.2-2.31.9-2.2-1.9-0.8-1.62.2-0.31.51.4
Patch foraging water rate 18 sec0.20.31.20.50.10.1-0.50.00.20.60.6-0.1-1.1-0.6-0.7
Patch foraging water rate 24 sec1.92.76.4-2.52.1-2.21.9-1.9-1.7-0.2-1.10.9-2.10.3-0.0
Patch foraging water rate 6 sec3.45.08.9-2.93.0-2.92.5-2.7-2.4-0.2-1.52.1-2.60.80.7
Seeking ratio, delayed vs. immediate footshock0.30.41.50.0-0.3-0.21.2-0.00.10.1-0.5-0.91.1-0.20.5
Distance traveled before self-admin0.10.10.5-0.40.1-0.10.2-0.2-0.30.7-0.20.20.1-0.00.2
Distance traveled after self-admin0.30.41.4-1.20.0-0.30.60.20.10.70.1-0.4-1.0-0.9-0.4
Extensor digitorum longus weight0.10.41.2-0.20.9-1.1-0.2-0.4-0.4-0.4-0.7-0.7-1.1-0.4-0.6
Bone: elastic displacement4.14.612.73.6-2.42.4-2.62.42.01.41.3-2.31.8-1.3-0.7
Bone: elastic work2.02.67.32.7-1.71.6-1.81.91.50.50.6-1.91.9-0.9-0.9
Bone: endosteal estimation1.12.311.30.7-0.1-0.4-1.50.61.00.61.5-0.3-3.4-2.1-2.2
Bone: endosteal perimeter1.02.011.5-0.71.7-2.10.1-0.9-0.80.8-0.30.6-3.4-0.9-1.2
Epididymis fat weight1.22.85.7-2.42.0-2.11.7-1.8-1.6-0.1-0.52.1-2.20.80.7
Delta time in closed arm before/after self-admin0.60.62.40.50.3-0.7-0.9-0.5-0.31.50.1-0.1-1.5-0.0-0.2
Delta time in open arm before/after self-admin0.90.92.20.6-1.31.5-0.61.31.2-0.50.8-0.90.7-0.60.0
Diff in mean of infusions in LGA sessions1.82.05.11.7-1.61.7-2.21.31.01.90.9-1.40.6-0.60.1
Delay discount exponential model param0.80.83.31.20.10.50.4-0.3-0.4-0.30.21.21.31.81.3
Extinction: sum of active levers before priming0.60.60.90.7-0.90.8-0.90.80.80.90.8-0.30.9-0.7-0.2
Active lever presses in extinction session 60.70.72.7-0.5-0.50.2-0.50.50.51.70.6-0.6-1.5-1.10.3
Bone: final force0.40.62.3-1.30.6-1.10.4-0.1-0.10.2-0.4-0.0-1.5-1.0-0.6
Bone: final moment0.30.51.3-1.10.5-1.10.4-0.1-0.20.5-0.6-0.2-1.2-0.9-0.2
Food consumed during 24 hour testing period0.50.61.60.41.1-0.70.6-1.1-0.8-0.9-0.31.3-0.31.10.2
Glucose0.10.10.90.20.1-0.20.3-0.4-0.30.5-0.10.30.10.40.9
Heart weight1.01.44.6-0.9-0.60.6-1.10.90.71.20.4-2.1-1.8-1.6-0.6
Delay discount hyperbolic model param0.70.72.61.30.00.50.3-0.2-0.3-0.40.31.31.11.61.1
Intermittent access intake day 1-15 change2.42.44.5-1.81.6-1.01.2-1.6-1.9-0.1-1.71.6-0.61.92.1
Intermittent access intake escalation2.92.97.1-1.81.7-1.11.3-1.7-2.10.2-1.81.8-0.32.12.7
Intermittent access intake escalation 20.80.82.4-1.60.8-0.30.5-0.7-1.0-0.0-0.91.0-0.71.01.0
Intermitt. access day 1 inactive lever presses1.31.44.32.1-1.51.3-1.21.11.20.50.9-1.8-0.0-0.1-0.2
Intermitt. access day 15 inactive lever presses0.80.92.20.7-1.31.5-0.91.21.00.10.7-1.00.7-0.7-0.8
Intermitt. access escalation Index1.91.75.02.2-1.41.5-1.71.11.11.51.1-1.60.1-0.4-0.0
Intermittent access day 1 total infusions1.92.24.3-1.62.1-1.71.0-1.8-1.6-1.9-1.41.9-0.50.90.2
Intermittent access day 15 total infusions4.65.28.7-2.72.9-2.22.0-2.6-2.6-1.9-2.42.7-1.21.91.4
Intermittent access terminal intake (last 3 days)3.74.07.3-2.62.7-2.21.3-2.4-2.3-1.6-2.02.4-1.21.40.9
Intermittent access total infusions3.64.07.8-2.82.7-2.11.4-2.3-2.3-1.8-2.02.5-0.91.30.7
Intermittent access day 1 locomotion1.92.07.2-1.51.7-1.81.4-1.4-1.1-2.7-1.01.5-0.60.7-0.3
Intermittent access day 15 total locomotion6.16.513.0-2.92.7-2.13.3-2.5-2.5-3.6-2.62.60.62.51.2
Intermittent access total locomotion3.84.311.1-2.52.5-2.32.2-2.1-1.8-3.3-1.82.4-0.11.3-0.0
Intermittent access standard deviation5.05.39.6-3.12.7-2.32.5-2.5-2.7-1.0-2.42.5-0.92.01.8
Left kidney weight2.15.810.2-3.23.1-2.92.9-2.9-2.9-1.1-2.61.3-0.82.11.6
Right kidney weight1.23.36.4-2.52.5-2.52.0-2.2-2.0-1.4-1.80.8-1.21.10.6
Cocaine induced anxiety1.92.14.41.2-1.71.7-2.11.51.80.31.6-0.80.5-1.6-1.6
Post-drug Anxiety2.02.24.91.9-1.81.8-2.21.51.60.51.4-0.71.0-1.0-1.3
Baseline Anxiety0.40.51.30.10.5-0.40.9-0.6-0.8-0.3-0.80.30.81.11.0
Tail length8.927.045.2-6.76.3-6.06.7-5.7-5.3-5.9-5.53.5-0.24.02.1
Length with tail11.843.184.0-9.28.1-7.68.2-7.3-6.8-6.7-6.74.5-1.54.92.5
Length without tail5.010.927.9-5.34.0-3.83.8-3.6-3.5-2.5-3.42.1-1.42.51.3
Times rat made contact with spout4.45.07.5-1.22.5-2.72.5-2.7-2.70.3-2.52.20.42.32.7
Lifetime Intake2.52.86.1-2.52.3-1.71.0-1.9-1.9-1.4-1.52.2-1.00.70.4
Liver weight, left0.10.20.7-0.20.2-0.40.1-0.1-0.30.80.2-0.0-0.80.10.2
Liver weight, right0.40.61.9-1.40.7-0.71.2-0.7-0.6-0.8-0.40.60.20.50.7
Locomotor activity2.54.09.4-3.12.5-2.71.6-2.3-2.40.6-1.90.7-1.90.91.3
Locomotor testing distance1.21.95.4-1.81.5-1.90.5-1.3-1.41.8-0.90.3-2.3-0.00.7
Locomotor testing rearing0.50.82.0-1.41.0-1.10.2-0.8-1.10.7-1.00.6-1.10.50.4
Locomotion in novel chamber0.10.10.40.60.1-0.10.3-0.10.00.3-0.3-0.10.4-0.1-0.1
Locomotion in novel chamber post-restriction0.70.83.2-0.10.8-0.90.9-0.9-0.5-1.4-0.51.80.70.5-0.3
Fecal boli incidents, locomotor time 10.50.52.4-0.60.4-0.61.2-0.2-0.0-1.5-0.20.70.50.3-0.7
Change in fecal boli incidents, locomotor task2.01.94.81.2-1.31.0-2.21.41.31.41.8-1.1-0.9-1.3-1.1
Time >=10cm from walls, locomotor time 11.41.44.10.8-1.20.8-2.01.01.11.51.1-1.2-0.7-1.4-0.9
Bouts of movement, locomotor time 10.40.41.4-0.1-0.41.0-0.20.80.60.30.2-1.20.1-0.9-0.4
Total resting periods, locomotor time 10.50.51.7-0.0-0.61.3-0.40.90.60.40.2-1.30.7-0.7-0.2
Rest time, locomotor task time 11.11.23.80.9-1.42.0-0.91.41.20.10.7-0.41.7-0.6-0.5
Distance moved, locomotor task time 11.11.22.8-1.11.0-1.11.2-1.4-1.40.8-0.90.8-0.31.21.7
Vertical activity count, locomotor time 11.61.63.1-0.71.4-1.81.1-1.8-1.51.6-0.90.2-1.10.71.5
Time >=10cm from walls, locomotor time 21.01.14.00.7-0.71.1-0.50.4-0.01.5-0.3-0.02.00.61.9
Bouts of movement, locomotor time 20.30.31.3-0.60.20.2-0.60.40.1-0.0-0.0-0.8-1.2-0.6-0.9
Total resting periods, locomotor time 20.50.51.5-0.4-0.20.5-0.90.60.50.20.3-0.8-1.2-1.0-1.0
Rest time, locomotor task time 21.92.23.91.1-1.51.5-2.01.61.61.11.7-1.4-0.6-1.9-1.5
Distance moved, locomotor task time 21.71.93.9-0.71.0-0.51.6-1.4-1.50.0-1.31.31.92.02.0
Vertical activity count, locomotor time 24.24.58.4-1.72.2-2.22.8-2.6-2.5-0.0-2.21.50.82.22.9
Light reinforcement 10.10.10.40.10.3-0.00.6-0.3-0.30.10.20.6-0.40.4-0.0
Light reinforcement 20.50.72.00.7-0.40.7-0.30.81.0-0.71.20.1-0.8-0.9-1.4
Bone: marrow area1.02.311.20.7-0.0-0.4-1.50.61.00.51.5-0.3-3.3-2.1-2.2
Bone: maximum diameter0.91.66.0-0.91.7-2.20.6-1.2-1.10.8-0.60.5-2.4-0.4-0.4
Bone: maximum force0.30.51.9-0.40.1-0.6-0.20.40.40.30.0-0.7-1.2-1.4-1.1
Bone: maximum moment0.20.41.7-0.2-0.0-0.5-0.20.40.30.7-0.2-0.9-0.8-1.3-0.7
Mean time between licks in bursts0.30.42.2-0.20.4-0.5-0.5-0.2-0.41.5-0.4-1.0-0.9-0.20.1
Mean num. licks in bursts0.30.40.9-0.20.5-0.50.6-0.7-0.8-0.2-1.00.20.70.90.7
Cd content in liver0.30.31.3-0.50.6-0.5-0.0-0.3-0.20.70.0-0.6-1.1-0.70.1
Co content in liver2.22.64.6-1.22.0-1.82.2-1.9-1.8-1.0-1.61.70.81.71.0
Cu content in liver0.80.91.8-0.21.3-1.21.1-1.1-0.9-1.2-0.60.9-0.61.10.3
Fe content in liver0.50.62.4-1.10.5-0.60.1-0.10.0-0.80.0-0.3-1.5-0.9-1.1
K content in liver2.52.57.9-0.80.7-0.42.2-1.1-0.8-2.8-1.11.32.02.21.5
Mg content in liver0.40.41.3-0.40.3-0.10.5-0.4-0.3-1.2-0.30.50.61.10.8
Mn content in liver0.20.20.4-0.50.7-0.70.4-0.6-0.5-0.2-0.20.4-0.30.50.6
Na content in liver0.50.51.7-0.20.3-0.01.1-0.4-0.3-1.3-0.20.91.20.80.4
Rb content in liver0.81.06.30.50.20.20.40.10.3-2.5-0.30.62.10.5-0.7
Se content in liver0.50.64.2-0.6-0.20.2-0.30.10.4-0.31.2-0.2-2.1-0.2-0.6
Sr content in liver0.60.61.8-1.0-0.20.21.30.1-0.30.1-0.90.51.20.11.3
Zn content in liver0.30.30.90.10.7-0.50.3-0.7-0.6-0.9-0.6-0.2-0.60.90.3
Bone: minimum diameter1.73.29.3-2.22.4-3.11.1-1.8-1.80.7-1.40.8-2.8-0.20.0
Time in familiar zone, hab. session 10.50.40.80.9-0.70.8-0.60.60.60.60.9-0.8-0.0-0.4-0.6
Time in novel zone, hab. session 10.40.42.00.5-0.1-0.1-1.40.30.40.30.4-0.4-0.9-0.9-0.8
Total zone transitions, hab. session 11.52.16.7-2.60.7-1.22.0-1.1-1.41.3-1.10.5-0.50.92.3
Total locomotion distance, hab. session 11.31.95.0-2.20.6-0.91.6-1.2-1.41.5-0.90.9-0.71.32.2
Locomotion velocity, hab. session 12.23.28.6-2.60.9-1.22.3-1.5-1.81.6-1.41.3-0.31.82.9
Time in familiar zone, hab. session 20.40.41.31.0-0.20.1-0.80.10.20.80.3-0.91.1-0.20.2
Time in novel zone, hab. session 20.70.72.3-0.0-0.70.7-0.50.90.90.10.7-0.7-1.5-1.1-1.1
Total zone transitions, hab. session 20.60.83.1-1.8-0.3-0.30.60.0-0.11.70.0-0.8-1.2-0.50.8
Total locomotion distance, hab. session 20.81.17.4-1.2-0.2-0.20.0-0.2-0.42.70.1-0.5-1.60.11.2
Locomotion velocity, hab. session 20.81.17.0-1.3-0.2-0.20.2-0.2-0.42.60.1-0.3-1.60.11.2
Novel to familiar place preference ratio0.80.85.10.60.10.50.7-0.2-0.3-1.2-0.30.62.31.10.5
Novelty place preference0.80.85.91.1-0.20.80.40.0-0.1-0.9-0.10.32.41.00.5
Time in novel zone, NPP test0.60.64.51.0-0.10.60.2-0.0-0.1-0.8-0.10.12.10.80.5
Total zone transitions, NPP test0.81.26.5-2.50.3-0.91.1-0.3-0.40.7-0.4-1.2-1.6-0.40.4
Total locomotion distance, NPP test0.81.24.6-2.20.4-0.81.2-0.7-0.81.2-0.5-0.3-1.40.51.4
Locomotion velocity, NPP test0.60.93.8-2.00.2-0.51.2-0.5-0.60.9-0.4-0.1-1.20.51.2
Intraocular pressure0.20.30.50.3-0.70.5-0.10.70.70.30.70.5-0.2-0.6-0.3
Delta distance traveled before/after self-admin0.20.20.8-0.90.2-0.40.9-0.0-0.0-0.2-0.1-0.5-0.5-0.40.1
Delta ambulatory time before/after self-admin0.30.30.9-0.6-0.50.30.10.80.70.00.6-0.8-0.4-0.9-0.4
Parametrial fat weight1.22.34.61.3-1.51.1-1.61.51.61.71.7-1.4-1.3-2.1-1.2
Pavlov. Cond. lever latency0.50.73.1-0.10.6-0.6-0.8-0.10.2-0.70.4-0.6-1.3-1.1-1.8
Pavlov. Cond. magazine entry latency0.50.63.80.1-0.80.7-0.00.50.42.00.7-0.40.0-0.30.9
Pavlov. Cond. change in total contacts0.40.42.3-0.2-0.2-0.00.3-0.2-0.21.30.20.9-0.20.41.5
Pavlov. Cond. index score0.50.73.2-0.1-0.80.70.40.30.11.80.2-0.00.60.31.6
Pavlov. Cond. latency score0.60.73.1-0.1-0.80.70.80.30.01.50.00.21.00.61.8
Pavlov. Cond. lever contacts0.91.15.2-0.6-0.20.11.2-0.4-0.70.7-0.81.01.11.42.3
Pavlov. Cond. magazine entry number0.40.43.1-0.10.7-0.50.1-0.3-0.3-1.8-0.60.30.20.3-0.8
Pavlov. Cond. intertrial magazine entries1.01.24.20.00.0-0.2-1.90.50.50.90.8-0.9-2.0-1.4-1.5
Pavlov. Cond. lever-magazine prob. diff.0.50.63.4-0.3-0.80.60.40.30.11.80.2-0.20.40.11.6
Pavlov. Cond. response bias0.50.73.7-0.1-0.30.20.3-0.2-0.31.7-0.00.60.40.71.9
Pavlov. Cond. lever latency0.30.51.40.20.9-0.50.5-0.6-0.7-1.2-1.20.60.60.1-0.1
Pavlov. Cond. magazine entry latency0.30.30.90.10.5-0.6-0.0-0.7-0.70.6-0.40.60.60.90.6
Pavlov. Cond. change in total contacts0.71.04.6-2.10.9-1.30.8-0.9-0.80.7-0.10.0-1.40.20.2
Pavlov. Cond. index score0.20.30.5-0.70.4-0.70.2-0.6-0.50.70.20.4-0.50.70.5
Pavlov. Cond. latency score0.10.20.3-0.50.2-0.40.2-0.5-0.30.60.30.4-0.40.60.4
Pavlov. Cond. lever contacts0.50.73.4-0.6-0.60.1-0.60.40.41.81.1-0.5-1.5-0.30.5
Pavlov. Cond. magazine entry number0.30.41.30.5-0.60.9-0.20.80.7-1.2-0.1-0.40.6-0.5-0.4
Pavlov. Cond. intertrial magazine entries0.50.62.31.5-0.50.8-1.10.50.40.40.3-1.40.5-0.20.1
Pavlov. Cond. lever-magazine prob. diff.0.40.50.9-0.90.7-0.90.5-0.9-0.80.6-0.20.6-0.30.90.7
Pavlov. Cond. response bias0.40.53.2-0.80.0-0.4-0.4-0.2-0.21.80.5-0.2-1.00.10.6
Time in closed arm before self-admin0.20.30.4-0.20.6-0.40.6-0.5-0.6-0.5-0.6-0.30.60.50.3
Time in closed arm after self-admin0.30.30.80.50.3-0.3-0.7-0.2-0.10.90.30.2-0.8-0.3-0.9
Time in open arm before self-admin0.10.10.40.2-0.1-0.1-0.10.20.10.60.1-0.3-0.4-0.1-0.3
Time in open arm after self-admin0.50.51.30.6-1.01.1-0.41.00.80.10.5-1.10.5-0.20.4
Bone: periosteal estimation0.61.37.9-0.50.9-1.5-0.5-0.2-0.00.40.2-0.1-2.8-1.4-1.6
Bone: periosteal perimeter0.61.05.2-0.81.1-1.70.0-0.5-0.50.7-0.40.1-2.3-0.8-0.8
Bone: post-yield work0.10.20.7-0.20.2-0.3-0.2-0.20.1-0.40.20.3-0.8-0.3-0.9
Progressive ratio test 1 active lever presses7.27.612.7-3.03.6-3.52.7-3.4-3.0-2.5-2.73.1-0.61.81.5
Progressive ratio test 1 breakpoint6.26.511.1-2.83.3-3.22.4-3.2-2.8-2.0-2.52.9-0.81.71.5
Progressive ratio test 1 inactive lever presses0.30.41.0-0.40.5-0.31.0-0.7-0.5-1.0-0.60.6-0.10.40.5
Progressive ratio test 2 active lever presses3.74.06.7-2.12.6-1.91.7-2.4-2.4-1.5-2.32.3-0.21.81.5
Progressive ratio test 2 breakpoint4.65.18.2-2.52.9-2.21.9-2.7-2.8-1.3-2.62.7-0.12.01.9
Progressive ratio test 2 inactive lever presses0.60.71.4-1.00.7-0.50.7-0.9-0.8-1.2-0.91.1-0.30.80.8
Incentive Sensitization - Responses3.53.65.9-1.92.3-1.71.7-2.2-2.4-1.1-2.41.70.22.31.7
Incentive Sensitization - Breakpoint3.23.25.3-1.72.2-1.61.6-2.1-2.3-1.1-2.31.60.42.21.6
Sum of active levers in priming session hrs 5-60.80.84.4-0.6-0.1-0.00.1-0.2-0.52.0-0.30.2-0.50.32.1
Progressive ratio1.11.22.90.6-1.41.3-0.81.61.3-0.10.9-0.50.7-1.2-1.7
Food seeking constrained by brief footshock1.92.43.7-1.91.8-1.91.8-1.8-1.7-1.3-1.81.00.31.21.2
Seeking ratio, punishment vs. effort1.41.73.3-1.11.7-1.61.2-1.8-1.6-0.4-1.30.4-0.21.31.6
Retroperitoneal fat weight1.03.36.6-2.62.3-2.32.6-2.1-1.9-0.4-1.21.4-1.90.80.9
Reaction time number correct0.10.20.7-0.2-0.00.1-0.20.20.10.7-0.10.4-0.5-0.80.5
Reaction time mean minus median0.81.04.31.3-1.10.9-1.00.91.00.20.6-2.10.6-0.5-0.5
Reaction time mean minus median AUC0.60.82.81.2-1.00.9-1.10.60.60.60.4-1.70.7-0.10.3
Reaction time num false alarms0.50.72.01.4-0.90.9-0.80.70.8-0.10.5-1.30.9-0.1-0.2
Reaction time num false alarms AUC1.01.43.51.8-1.31.4-1.31.21.20.30.8-1.90.8-0.5-0.5
Reaction time trials correct on left0.10.20.7-0.2-0.00.1-0.20.20.10.7-0.10.4-0.5-0.80.5
Reaction time trials on left0.10.20.8-0.0-0.10.2-0.30.30.20.8-0.10.2-0.5-0.90.4
Reaction time mean0.40.61.80.1-0.1-0.4-1.00.00.11.20.3-1.3-1.3-0.6-0.4
Reaction time mean AUC0.30.41.3-0.00.2-0.7-0.7-0.2-0.10.8-0.0-1.1-1.2-0.4-0.2
Median of all reaction times0.50.63.6-0.60.6-0.9-0.6-0.4-0.31.10.1-0.6-1.9-0.4-0.3
Reaction time omissions4.56.115.94.0-2.32.2-3.42.32.32.12.2-3.0-0.3-2.1-1.5
Reaction time false alarm rate0.81.23.11.7-1.21.1-1.11.01.1-0.20.9-1.80.8-0.1-0.8
Reaction time premature initiation rate0.30.41.7-0.2-0.30.11.00.30.21.30.4-0.4-1.0-0.60.4
Reaction time premature initiations0.30.41.5-0.30.0-0.11.1-0.0-0.11.2-0.10.0-0.7-0.51.0
Std. dev. reaction times1.11.66.61.7-1.31.0-1.51.11.10.90.7-2.60.3-0.7-0.5
Reaction time trials completed0.10.20.8-0.0-0.10.2-0.30.30.20.8-0.10.2-0.5-0.90.4
Reaction time trials AUC0.10.20.8-0.2-0.00.1-0.20.20.10.7-0.10.4-0.6-0.90.5
Run reversals in cocaine runway, females0.50.41.4-1.20.4-0.90.9-0.4-0.3-0.8-0.60.8-0.1-0.3-0.4
Run reversals in cocaine runway, males0.10.10.9-0.2-0.10.2-0.4-0.1-0.10.40.10.00.20.10.9
Latency to leave start box in cocaine runway0.20.31.80.50.1-0.2-0.5-0.3-0.31.3-0.10.00.20.00.8
Latency to leave start box in cocaine runway, F0.60.73.40.5-0.80.5-1.10.60.41.81.1-0.2-0.1-0.50.4
Latency to leave start box in cocaine runway, M1.91.83.8-0.11.7-1.41.4-1.7-1.5-1.4-2.00.60.61.61.0
Std. dev. time between licks in bursts1.72.05.00.2-1.31.0-1.81.41.02.21.1-2.0-1.5-1.3-0.7
Total sessions with >9 infusions1.41.53.4-1.41.7-1.60.5-1.3-1.1-1.3-0.81.8-1.40.1-0.2
Short access day 1 total inactive lever presses0.20.31.9-0.20.00.0-0.7-0.00.0-0.30.10.3-1.4-0.2-0.7
Short access day 10 total inactive lever presses4.75.212.93.6-3.03.0-2.82.32.21.82.0-2.01.4-0.5-0.7
Short access day 1 total infusions0.60.61.7-0.61.3-1.10.1-1.0-1.0-0.0-0.61.1-0.60.00.2
Short access day 10 total infusions3.23.68.7-2.92.6-2.11.6-2.3-2.1-1.4-1.71.8-1.10.90.8
Short access total infusions2.02.24.6-2.12.1-1.70.9-1.8-1.7-0.5-1.32.1-1.00.50.8
Short access day 1 locomotion1.71.84.1-0.71.6-2.01.4-1.7-1.5-0.7-1.31.8-0.11.01.2
Short access day 10 total locomotion0.30.31.4-0.50.3-1.20.4-0.3-0.2-0.7-0.1-0.5-0.70.1-0.4
Short access total locomotion2.72.85.5-1.71.8-2.42.0-1.8-1.7-1.3-1.61.8-0.11.31.4
One hour access (0.3 mA shock)4.25.012.1-3.52.6-2.22.3-2.3-2.6-1.7-2.42.2-0.21.71.6
Compulsive drug intake1.51.54.92.2-1.81.5-0.51.31.30.70.9-1.40.9-0.70.3
One hour access (shock baseline)5.56.316.1-4.03.1-2.32.3-2.6-2.9-1.9-2.62.80.02.11.2
Social response proportion0.60.62.7-1.20.8-1.00.0-0.4-0.50.4-0.5-0.7-1.7-0.3-0.1
Social responses0.50.62.3-1.20.6-0.40.2-0.4-0.81.5-0.9-0.5-0.70.01.0
Social time0.81.12.9-1.01.0-1.20.4-1.1-1.20.2-1.40.8-0.10.91.7
Soleus weight0.20.52.6-0.40.2-0.7-0.10.20.20.50.1-0.6-1.6-1.3-0.7
Bone: stiffness1.21.86.5-2.51.2-1.91.3-0.9-0.5-0.3-0.5-0.0-2.5-0.9-0.4
Tibialis anterior weight0.41.33.70.2-0.4-0.0-1.30.90.81.00.5-1.6-1.6-1.9-1.2
Time to tail flick, vehicle, before self-admin4.84.98.1-1.42.6-2.42.8-2.6-2.7-0.2-2.41.9-0.52.62.4
Time to tail flick, vehicle, after self-admin1.51.64.10.3-1.61.4-2.01.51.21.41.2-1.10.3-1.2-0.3
Time to tail flick, test, before self-admin0.30.30.6-0.60.5-0.60.4-0.2-0.1-0.8-0.2-0.4-0.7-0.4-0.7
Time to tail flick, test, after self-admin0.00.00.1-0.20.10.2-0.20.1-0.20.4-0.10.2-0.10.20.3
Delta time to tail flick, vehicle, before/after SA5.45.312.01.4-2.92.5-3.52.82.61.52.5-1.90.4-2.4-1.6
Delta time to tail flick, test, before/after SA0.20.20.7-0.1-0.30.7-0.40.2-0.10.5-0.10.50.40.60.8
Tibia length6.017.031.4-5.25.6-5.64.6-5.0-4.8-1.8-4.13.0-2.52.81.3
Ambulatory time before self-admin0.20.20.5-0.30.3-0.10.6-0.4-0.3-0.3-0.40.70.70.40.0
Ambulatory time after self-admin0.30.31.4-1.20.2-0.30.90.10.00.20.1-0.4-0.6-0.8-0.5
Bone: tissue strength0.40.42.1-1.50.4-0.70.6-0.4-0.4-0.2-0.50.0-0.6-0.10.6
Total heroin consumption1.41.64.11.1-1.30.8-1.01.21.11.91.3-1.1-2.0-1.30.2
Bone: trabecular number0.20.42.20.1-0.40.50.50.30.3-0.6-0.20.91.50.20.2
Bone: trabecular spacing0.20.31.01.0-0.40.6-0.70.40.10.60.0-0.70.80.10.0
Bone: trabecular thickness0.20.20.6-0.10.4-0.40.3-0.5-0.4-0.5-0.50.80.50.60.6
Bone: trabecular tissue density0.20.31.1-1.10.1-0.01.0-0.20.0-0.70.31.1-0.50.10.2
Water consumed over 24 hours1.01.32.9-0.21.7-1.40.9-1.5-1.2-1.1-1.01.2-0.41.00.8
Number of responses in last shaping day1.01.01.6-1.21.3-1.10.7-1.2-1.2-0.6-1.31.3-0.10.60.6