Hub : Genes

Plxnb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose intron excision ratio chr7_122125188_122127702 0.03 0.02 2.6e-03 0 0 0 0 1.7e-01 8.4e-02 8.8e-02 1.6e-01
2 NAcc alternative polyA NM_001108106.1 0.01 0.01 9.0e-03 0.01 0 0 0 1.9e-02 7.1e-02 1.2e-01 1.5e-01
3 NAcc alternative polyA NM_001108106.1 0.01 0.01 7.8e-03 0.01 0 0 0 1.7e-02 6.4e-02 1.1e-01 1.3e-01
4 BLA gene expression Plxnb2 0.31 0.13 2.4e-15 0.29 0.27 0.29 0.28 7.6e-16 1.7e-14 1.5e-15 3.0e-15
5 Brain gene expression Plxnb2 0.36 0.12 0.0e+00 0.38 0.38 0.39 0.39 6.3e-38 2.8e-37 4.1e-38 2.2e-38
6 PL gene expression Plxnb2 0.43 0.17 0.0e+00 0.38 0.36 0.36 0.37 4.8e-44 4.5e-41 6.8e-41 3.8e-42
7 LHb gene expression Plxnb2 0.38 0.23 5.6e-05 0.22 0.14 0.19 0.16 6.9e-06 3.5e-04 3.4e-05 1.5e-04
8 Adipose gene expression Plxnb2 0.09 0.04 2.2e-16 0.12 0.13 0.12 0.13 2.7e-13 1.3e-14 2.5e-13 4.1e-14
9 NAcc gene expression Plxnb2 0.23 0.12 0.0e+00 0.23 0.23 0.23 0.22 1.2e-33 4.5e-34 5.9e-34 1.5e-33
10 IC gene expression Plxnb2 0.47 0.15 0.0e+00 0.35 0.42 0.44 0.44 2.8e-15 3.4e-19 6.4e-20 4.6e-20
11 IL gene expression Plxnb2 0.63 0.15 2.9e-11 0.39 0.43 0.49 0.45 2.4e-10 1.3e-11 1.8e-13 3.6e-12
12 NAcc intron excision ratio chr7_122125188_122126641 0.03 0.02 5.2e-03 0.01 0.01 0.01 0.01 1.4e-02 5.0e-03 2.1e-02 8.1e-03
13 OFC gene expression Plxnb2 0.66 0.21 3.0e-09 0.36 0.38 0.36 0.37 2.6e-09 7.3e-10 1.7e-09 7.8e-10
14 pVTA gene expression Plxnb2 0.07 0.06 1.9e-05 0.06 0.07 0.08 0.07 2.8e-05 2.9e-06 9.3e-07 5.0e-06
15 pVTA mRNA stability Plxnb2 0.05 0.04 2.9e-03 0.02 0.02 0.02 0.01 8.8e-03 8.2e-03 1.5e-02 2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.91.52.51.2-1.5-1.5-1.6-1.4-1.6-1.0-1.4-1.2-1.4-0.80.0-0.9-0.61.2
Area under the delay curve1.01.22.40.2-0.9-0.9-0.5-1.0-1.1-1.1-1.1-1.1-1.4-1.11.3-1.0-1.21.6
BMI with tail3.612.418.7-4.34.04.03.43.93.93.93.73.83.23.51.93.72.7-1.5
BMI without tail2.06.27.6-2.42.72.72.22.72.72.72.72.72.62.70.12.62.5-1.9
Body weight1.66.810.5-3.22.82.83.02.82.72.92.82.72.72.71.22.52.0-1.3
Weight adjusted by age1.82.86.4-2.51.91.92.01.81.71.81.71.61.51.41.71.50.8-0.3
Bone surface1.12.03.90.5-1.6-1.6-1.5-1.5-1.7-1.0-1.5-1.4-1.6-1.21.2-1.0-1.32.0
Bone volume1.32.33.51.0-1.7-1.7-1.8-1.7-1.9-1.3-1.7-1.5-1.6-1.40.8-1.2-1.21.8
Breakpoint value in progressive ratio session0.20.20.9-0.70.30.30.70.30.30.30.20.20.00.70.90.30.40.4
Number of licking bursts0.00.00.20.3-0.1-0.1-0.2-0.1-0.1-0.1-0.00.0-0.2-0.1-0.40.00.2-0.2
Context. condit. distance diff. score1.92.43.7-1.21.61.61.51.71.71.61.71.61.91.6-0.41.41.4-1.5
Locomotion velocity, session 10.20.20.3-0.50.40.40.20.50.50.50.30.40.00.50.40.50.60.0
Locomotion distance, session 12.22.73.51.4-1.9-1.9-1.4-1.8-1.8-1.7-1.8-1.8-1.7-1.80.2-1.8-1.71.4
Locomotion velocity, session 20.70.81.7-1.00.90.90.41.11.11.10.91.10.11.10.61.30.9-0.1
Locomotion distance, session 21.01.41.90.9-1.4-1.4-0.8-1.3-1.3-1.1-1.3-1.3-1.3-1.40.1-1.3-1.10.9
Locomotion velocity, session 30.70.83.90.40.40.40.40.50.50.70.80.70.80.6-2.00.51.2-1.7
Locomotion distance, session 30.10.10.60.7-0.1-0.1-0.8-0.4-0.4-0.1-0.2-0.1-0.4-0.0-0.60.00.2-0.1
Stereotopy head waving bouts, day 31.92.33.91.2-1.6-1.6-1.9-1.6-1.5-1.5-1.7-1.5-2.0-1.50.5-1.2-1.21.6
Stereotopy head waving duration, day 30.60.71.21.0-1.0-1.0-1.1-0.9-0.8-0.9-0.9-0.9-1.0-0.7-0.3-0.7-0.40.6
Locomotion velocity, session 71.01.13.00.01.41.40.10.70.70.81.11.20.91.1-1.01.31.7-1.2
Locomotion distance, session 70.30.30.7-0.20.80.80.50.30.30.40.70.60.80.4-0.40.40.5-0.8
Stereotopy head waving bouts, day 70.80.91.90.8-1.4-1.4-1.0-0.9-0.9-0.7-1.0-1.0-0.8-0.7-0.2-0.9-0.80.7
Stereotopy head waving duration, day 70.70.91.91.3-1.3-1.3-1.4-0.9-0.9-0.7-0.9-0.8-0.9-0.7-1.0-0.7-0.20.2
Locomotion velocity, session 81.51.84.1-0.81.31.30.41.41.51.51.41.50.61.8-0.41.82.0-0.9
Locomotion distance, session 80.50.71.6-1.20.70.71.21.00.91.00.90.81.00.70.60.70.3-0.3
Degree of sensitization distance1.31.32.8-1.71.21.21.51.31.31.11.11.11.10.91.11.00.5-0.3
Degree of sensitization stereotypy0.10.10.80.4-0.6-0.6-0.1-0.1-0.10.0-0.1-0.20.2-0.0-0.9-0.30.1-0.4
Conditioned locomotion0.60.71.2-0.50.90.90.51.11.10.70.90.90.60.9-0.31.00.7-0.7
Cocaine response after cond. corrected1.11.41.9-1.21.21.21.01.21.11.41.31.31.11.40.11.31.3-0.8
Cocaine response after cond. not corrected2.73.14.5-1.71.81.81.51.91.82.12.02.01.82.0-0.01.91.8-1.4
Cocaine response before conditioning0.91.11.6-1.01.11.10.81.31.21.31.11.21.01.00.21.20.9-0.6
Saline control response0.60.82.9-1.60.70.70.70.80.71.00.60.70.20.71.70.8-0.00.6
Bone: connectivity density0.61.02.01.1-1.2-1.2-1.4-1.1-1.3-0.7-1.0-0.9-1.3-0.4-0.3-0.5-0.30.8
Bone: cortical apparent density2.12.84.22.1-1.8-1.8-1.7-1.8-1.8-1.8-1.8-1.8-1.5-2.0-0.8-1.8-1.20.7
Bone: cortical area0.40.63.8-1.30.80.80.40.40.30.40.40.50.0-0.01.90.70.10.9
Bone: cortical porosity0.40.52.8-1.30.40.40.50.40.30.50.30.3-0.00.21.70.5-0.40.8
Bone: cortical porosity0.90.94.0-1.90.60.61.20.80.60.90.60.60.50.62.00.7-0.30.7
Bone: cortical thickness0.10.10.5-0.20.20.2-0.0-0.3-0.4-0.4-0.1-0.1-0.1-0.60.7-0.1-0.20.5
Bone: cortical thickness0.40.51.50.01.21.20.30.40.5-0.00.70.70.90.9-0.40.60.8-0.8
Bone: cortical tissue density1.82.43.71.9-1.7-1.7-1.6-1.7-1.6-1.7-1.7-1.7-1.4-1.9-0.9-1.7-1.20.6
Condit. Reinf. active minus inactive responses1.31.53.4-1.41.41.40.21.21.31.31.01.30.11.41.41.81.30.4
Condit. Reinf. active-inactive response ratio0.20.20.7-0.20.40.4-0.40.40.50.50.30.5-0.30.70.30.90.80.2
Condit. Reinf. active responses2.12.65.0-1.81.81.80.71.81.91.71.51.80.51.81.42.21.70.0
Condit. Reinf. inactive responses1.41.72.7-1.61.41.41.11.51.51.41.31.40.91.31.01.51.0-0.2
Incentive salience index mean2.02.44.7-2.01.81.80.61.61.81.61.41.60.31.61.92.21.40.4
Condit. Reinf. lever presses1.52.14.0-2.01.61.60.91.61.71.51.31.50.51.41.71.80.90.2
Condit. Reinf. active minus inactive responses0.60.83.5-0.2-0.2-0.2-0.5-0.7-0.7-0.9-0.8-0.7-1.0-0.31.9-0.4-0.71.7
Condit. Reinf. active-inactive response ratio0.20.20.70.10.10.1-0.5-0.6-0.7-0.6-0.4-0.4-0.7-0.10.8-0.1-0.10.8
Condit. Reinf. active responses0.50.65.3-1.00.50.5-0.00.10.1-0.3-0.1-0.0-0.40.32.30.4-0.41.5
Condit. Reinf. inactive responses0.40.51.8-1.20.70.70.60.80.90.40.50.60.50.61.30.7-0.20.4
Condit. Reinf. lever presses0.81.23.8-1.71.31.30.61.01.00.80.80.90.40.82.01.20.50.6
Condit. Reinf. lever reinforcers received0.50.75.5-0.90.30.3-0.1-0.0-0.1-0.4-0.3-0.2-0.60.12.30.2-0.61.6
Conditioned reinforcement - actives0.40.71.8-1.30.80.81.10.70.60.70.70.60.60.91.20.70.40.2
Conditioned reinforcement - inactives0.20.30.7-0.50.60.60.70.50.50.50.60.50.70.80.00.50.5-0.4
Conditioned locomotion2.22.84.3-2.11.81.82.11.81.81.81.81.71.91.60.81.51.1-0.9
Patch foraging indifference point 0 sec0.20.40.8-0.90.80.80.50.60.60.70.70.70.50.60.60.70.4-0.1
Patch foraging indifference point AUC1.21.75.3-0.5-1.1-1.1-0.9-0.8-0.9-0.8-1.2-1.1-1.3-1.12.3-0.9-1.82.2
Delay disc. indifference point, 0s delay0.90.96.2-1.70.50.50.80.50.60.60.30.4-0.4-0.42.50.7-0.01.3
Delay disc. indifference point, 16s delay0.30.31.0-0.1-0.4-0.4-0.0-0.4-0.4-0.3-0.5-0.5-0.9-0.11.0-0.3-0.51.0
Delay disc. indifference point, 2s delay4.14.611.20.3-1.9-1.9-1.6-1.9-1.9-1.9-2.2-2.1-2.8-2.12.9-1.5-2.33.4
Delay disc. indifference point, 24s delay0.50.51.8-0.61.01.00.90.70.60.60.60.7-0.01.30.30.70.7-0.3
Delay disc. indifference point, 4s delay1.41.53.90.1-1.2-1.2-0.3-1.1-1.1-1.1-1.2-1.3-0.9-2.01.2-1.3-1.61.4
Delay disc. indifference point, 8s delay0.91.11.60.9-1.0-1.0-0.7-1.2-1.3-1.3-1.2-1.3-0.9-1.10.2-1.3-1.10.9
Indifference point function ln k1.73.04.7-1.42.12.11.51.71.71.82.01.92.21.3-0.51.61.8-1.8
Indifference point function log k1.73.04.7-1.42.12.11.51.71.71.82.01.92.21.3-0.51.61.8-1.8
Patch foraging total patch changes 0 sec0.10.20.3-0.60.60.60.30.40.40.50.40.40.30.50.30.50.3-0.1
Patch foraging total patch changes 12 sec0.40.53.4-0.8-0.1-0.1-0.2-0.10.0-0.1-0.3-0.2-0.8-0.31.80.1-0.81.4
Patch foraging total patch changes 18 sec1.42.24.30.7-1.4-1.4-1.8-1.5-1.5-1.6-1.6-1.5-1.7-0.91.4-1.2-1.52.1
Patch foraging total patch changes 24 sec0.30.61.80.3-0.5-0.5-1.3-0.6-0.5-0.7-0.8-0.6-1.2-0.01.0-0.0-0.51.3
Patch foraging total patch changes 6 sec0.30.52.2-0.8-0.4-0.4-0.1-0.1-0.2-0.1-0.4-0.5-0.4-0.51.5-0.4-1.21.1
Patch foraging time to switch 0 sec0.10.30.80.9-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.7-0.1-0.6-0.3-0.00.1
Patch foraging water rate 0 sec0.51.03.3-1.01.11.10.91.01.00.91.21.01.80.4-0.10.60.5-1.1
Patch foraging water rate 12 sec1.22.54.7-1.81.91.91.71.61.51.61.81.62.21.00.31.31.1-1.2
Patch foraging water rate 18 sec3.04.68.7-1.82.32.32.42.01.92.12.42.22.92.1-0.71.72.0-2.3
Patch foraging water rate 24 sec1.11.54.6-0.91.01.01.31.21.01.31.41.22.20.9-0.90.71.0-1.7
Patch foraging water rate 6 sec0.60.82.2-0.91.01.01.10.80.80.91.10.91.50.4-0.30.60.6-1.1
Seeking ratio, delayed vs. immediate footshock0.40.41.01.0-0.9-0.9-0.5-0.7-0.7-0.8-0.7-0.7-0.6-0.5-0.6-0.6-0.10.3
Distance traveled before self-admin1.21.63.81.2-1.3-1.3-1.2-1.3-1.3-1.2-1.3-1.3-1.0-1.9-0.2-1.3-1.30.8
Distance traveled after self-admin0.10.10.60.5-0.1-0.1-0.4-0.1-0.0-0.1-0.00.1-0.1-0.0-0.80.10.4-0.4
Extensor digitorum longus weight0.41.52.5-1.11.41.41.31.21.11.31.31.31.41.6-0.11.21.1-1.0
Bone: elastic displacement0.30.40.90.3-1.0-1.0-0.2-0.7-1.0-0.4-0.6-0.7-0.3-0.3-0.1-0.8-0.50.4
Bone: elastic work0.20.20.7-0.80.30.30.80.3-0.00.50.40.30.50.60.60.20.1-0.0
Bone: endosteal estimation0.20.42.1-1.20.50.50.40.50.40.70.40.50.30.41.40.6-0.10.6
Bone: endosteal perimeter0.91.913.8-2.20.60.60.10.60.60.70.20.5-0.60.23.71.2-0.32.3
Epididymis fat weight1.65.59.1-3.02.72.71.92.52.62.42.22.40.82.52.53.02.10.2
Delta time in closed arm before/after self-admin0.10.10.5-0.2-0.1-0.10.5-0.2-0.2-0.1-0.2-0.30.1-0.00.5-0.4-0.70.3
Delta time in open arm before/after self-admin0.00.00.20.1-0.0-0.0-0.30.00.1-0.10.00.1-0.2-0.4-0.10.10.40.0
Diff in mean of infusions in LGA sessions1.11.33.5-1.91.01.01.31.11.11.10.90.90.61.21.91.10.50.5
Delay discount exponential model param0.80.91.7-0.30.80.80.41.01.01.01.11.11.20.9-1.00.91.1-1.3
Extinction: sum of active levers before priming0.30.31.0-0.2-0.6-0.6-0.1-0.5-0.5-0.4-0.6-0.6-0.4-0.41.0-0.5-0.31.0
Active lever presses in extinction session 62.22.23.0-1.71.51.51.61.61.61.41.51.51.61.70.41.41.6-0.9
Bone: final force0.10.20.60.00.00.0-0.5-0.5-0.6-0.4-0.4-0.3-0.5-0.70.8-0.2-0.60.7
Bone: final moment0.20.30.70.2-0.3-0.3-0.5-0.7-0.8-0.5-0.5-0.5-0.5-0.80.5-0.5-0.70.6
Food consumed during 24 hour testing period1.82.53.1-1.71.81.81.71.61.41.71.81.71.61.70.31.61.5-1.1
Glucose0.20.40.8-0.2-0.6-0.6-0.2-0.5-0.6-0.4-0.6-0.6-0.3-0.70.9-0.6-0.70.9
Heart weight0.40.61.3-0.20.80.80.50.80.80.70.80.90.60.7-0.80.81.1-1.0
Delay discount hyperbolic model param1.31.42.5-0.41.11.10.71.21.21.21.31.31.51.2-1.21.11.3-1.6
Intermittent access intake day 1-15 change0.40.91.8-1.40.90.91.21.01.01.01.00.91.11.10.70.80.6-0.3
Intermittent access intake escalation0.51.02.1-1.41.01.01.21.11.01.01.00.91.11.00.80.90.6-0.3
Intermittent access intake escalation 21.51.74.8-2.21.31.31.51.31.31.31.21.11.01.21.81.30.60.2
Intermitt. access day 1 inactive lever presses0.20.71.8-1.30.80.80.90.80.80.80.70.70.70.81.10.70.30.1
Intermitt. access day 15 inactive lever presses1.94.06.8-1.62.12.12.12.12.02.02.22.12.62.1-0.81.61.8-2.2
Intermitt. access escalation Index0.20.30.91.0-0.5-0.5-0.7-0.5-0.5-0.5-0.4-0.4-0.3-0.4-0.9-0.40.2-0.2
Intermittent access day 1 total infusions0.10.10.30.10.20.20.50.10.10.20.20.20.40.4-0.50.10.5-0.5
Intermittent access day 15 total infusions0.20.31.1-0.60.50.51.10.50.40.40.50.50.90.80.10.30.5-0.4
Intermittent access terminal intake (last 3 days)1.11.53.5-1.71.21.21.91.21.11.21.21.11.41.31.00.90.8-0.4
Intermittent access total infusions0.20.30.8-0.60.50.50.90.40.40.40.40.40.70.60.30.30.5-0.2
Intermittent access day 1 locomotion0.00.00.1-0.1-0.0-0.00.1-0.1-0.1-0.1-0.1-0.10.1-0.20.3-0.1-0.00.3
Intermittent access day 15 total locomotion0.51.02.2-1.50.90.91.31.01.01.10.90.91.10.81.00.80.5-0.2
Intermittent access total locomotion0.70.81.5-1.10.90.91.20.90.91.00.90.91.20.90.30.70.7-0.5
Intermittent access standard deviation0.30.71.7-0.40.70.71.10.70.70.70.90.81.30.8-0.70.51.0-1.1
Left kidney weight4.219.730.7-5.54.64.65.15.04.85.14.74.64.24.42.14.53.4-2.2
Right kidney weight6.630.042.6-6.55.75.76.26.15.96.25.95.85.45.72.05.54.5-3.1
Cocaine induced anxiety0.91.32.5-1.01.21.21.61.21.21.21.31.11.60.8-0.40.80.9-1.3
Post-drug Anxiety1.61.73.4-1.01.31.31.71.41.31.31.51.31.80.9-0.70.91.0-1.6
Baseline Anxiety0.30.40.70.8-0.7-0.7-0.7-0.7-0.6-0.6-0.6-0.6-0.5-0.4-0.5-0.6-0.50.2
Tail length0.31.12.11.2-1.4-1.4-1.0-1.2-1.3-1.0-1.1-1.1-0.8-0.8-0.6-1.1-0.60.5
Length with tail0.00.10.4-0.3-0.3-0.30.6-0.2-0.4-0.1-0.2-0.30.0-0.10.5-0.4-0.40.3
Length without tail0.20.83.2-1.70.50.51.60.70.50.70.50.40.60.31.80.3-0.30.5
Times rat made contact with spout1.82.06.3-0.11.11.11.81.00.81.01.41.12.31.3-2.10.41.2-2.5
Lifetime Intake0.30.41.2-0.60.60.61.10.50.40.50.60.50.80.80.10.30.6-0.4
Liver weight, left0.20.32.2-1.20.30.30.10.30.30.30.20.20.2-0.51.50.0-0.30.6
Liver weight, right0.20.41.2-0.2-0.6-0.60.0-0.4-0.4-0.5-0.5-0.60.0-1.00.7-0.8-1.10.6
Locomotor activity0.30.53.3-1.30.30.30.20.40.40.50.20.3-0.1-0.31.80.5-0.31.0
Locomotor testing distance0.61.12.60.9-1.1-1.1-1.4-1.0-0.9-1.1-1.1-1.0-0.9-1.6-0.0-1.0-0.90.7
Locomotor testing rearing0.91.87.1-0.7-0.9-0.9-0.8-0.8-0.7-0.9-1.1-1.1-1.2-1.22.7-0.8-1.82.4
Locomotion in novel chamber2.02.65.4-0.41.31.31.31.61.61.11.71.62.32.1-1.81.21.5-2.3
Locomotion in novel chamber post-restriction0.20.30.9-0.1-0.3-0.3-1.0-0.3-0.3-0.4-0.4-0.3-0.4-0.00.9-0.0-0.81.0
Fecal boli incidents, locomotor time 10.30.51.01.0-0.7-0.7-1.0-0.8-0.8-0.8-0.8-0.7-0.7-0.5-0.4-0.6-0.30.4
Change in fecal boli incidents, locomotor task0.30.30.7-0.90.70.70.70.60.50.60.60.50.80.50.40.30.4-0.4
Time >=10cm from walls, locomotor time 10.30.31.1-1.00.50.50.40.60.60.70.50.50.30.30.90.60.30.2
Bouts of movement, locomotor time 10.70.83.9-0.10.90.90.50.70.70.70.70.80.42.0-0.50.91.4-0.7
Total resting periods, locomotor time 10.40.43.00.30.50.50.20.30.30.30.30.30.21.7-0.70.51.0-0.5
Rest time, locomotor task time 10.30.42.51.00.10.1-0.5-0.0-0.0-0.00.10.10.21.1-1.60.00.5-1.0
Distance moved, locomotor task time 10.20.31.6-1.00.20.20.60.40.40.40.30.3-0.0-0.61.30.40.00.6
Vertical activity count, locomotor time 10.41.03.4-1.71.01.00.80.90.90.80.80.90.2-0.41.81.00.30.6
Time >=10cm from walls, locomotor time 21.31.93.9-2.01.61.61.41.41.41.61.41.41.01.31.41.40.8-0.2
Bouts of movement, locomotor time 20.10.20.50.7-0.5-0.5-0.3-0.6-0.6-0.7-0.5-0.6-0.2-0.4-0.3-0.6-0.10.2
Total resting periods, locomotor time 20.20.30.60.7-0.5-0.5-0.5-0.7-0.6-0.8-0.6-0.6-0.3-0.4-0.2-0.6-0.20.4
Rest time, locomotor task time 20.60.82.71.6-0.8-0.8-1.3-0.8-0.8-0.8-0.7-0.7-0.3-0.1-1.6-0.70.1-0.4
Distance moved, locomotor task time 21.31.64.2-2.11.41.41.21.31.31.31.21.30.70.61.81.30.30.2
Vertical activity count, locomotor time 21.31.84.5-2.11.71.71.01.31.41.31.31.30.70.51.91.40.20.2
Light reinforcement 10.30.72.2-1.50.60.60.50.90.80.90.60.70.20.51.51.00.30.5
Light reinforcement 21.72.68.2-2.91.51.51.91.61.41.71.51.41.21.02.51.50.60.3
Bone: marrow area0.10.31.9-1.10.30.30.30.40.30.60.30.30.10.31.40.5-0.10.7
Bone: maximum diameter1.01.93.7-1.91.61.60.71.51.51.31.21.40.50.91.91.81.00.5
Bone: maximum force0.00.10.4-0.20.10.10.1-0.3-0.6-0.1-0.1-0.1-0.1-0.30.6-0.2-0.40.3
Bone: maximum moment0.10.10.5-0.0-0.2-0.20.0-0.5-0.7-0.2-0.3-0.3-0.1-0.40.4-0.4-0.50.3
Mean time between licks in bursts1.12.76.02.5-1.7-1.7-1.9-1.8-1.7-1.7-1.6-1.6-1.4-1.5-1.7-1.6-1.00.2
Mean num. licks in bursts0.20.41.7-0.10.40.41.10.30.20.30.50.21.30.5-0.7-0.20.2-1.0
Cd content in liver0.50.50.80.5-0.7-0.7-0.7-0.9-0.8-0.6-0.9-0.9-0.7-0.30.5-0.8-0.80.9
Co content in liver0.20.31.2-1.00.20.20.30.40.20.90.30.4-0.30.21.10.50.00.5
Cu content in liver0.80.96.01.8-0.2-0.2-0.8-0.6-0.5-0.7-0.2-0.30.1-0.4-2.4-0.50.5-1.3
Fe content in liver0.30.30.8-0.1-0.4-0.4-0.3-0.6-0.7-0.6-0.5-0.6-0.5-0.60.9-0.5-0.80.8
K content in liver0.20.20.70.4-0.4-0.4-0.9-0.0-0.1-0.1-0.3-0.1-0.8-0.0-0.20.20.30.3
Mg content in liver0.90.91.90.5-1.3-1.3-1.1-0.7-0.7-0.7-1.0-0.9-1.4-1.00.4-0.7-0.81.2
Mn content in liver0.10.10.7-0.1-0.1-0.1-0.50.10.10.3-0.10.1-0.80.10.40.50.40.6
Na content in liver4.34.67.41.8-2.0-2.0-2.7-2.3-2.3-2.4-2.4-2.2-2.6-1.90.9-1.7-1.92.4
Rb content in liver0.10.20.9-0.4-0.3-0.3-0.2-0.1-0.1-0.1-0.3-0.2-0.4-0.21.0-0.1-0.60.8
Se content in liver0.40.51.2-0.40.50.50.50.80.90.80.70.70.71.1-0.50.70.8-0.7
Sr content in liver1.21.12.71.6-1.0-1.0-1.2-1.1-1.1-1.1-0.9-0.9-0.7-1.0-1.3-1.0-0.5-0.1
Zn content in liver0.50.62.61.2-0.9-0.9-0.4-0.5-0.4-0.5-0.5-0.5-0.2-0.6-1.6-0.8-0.3-0.7
Bone: minimum diameter0.30.52.8-1.10.80.80.10.40.30.50.40.5-0.10.21.70.90.20.8
Time in familiar zone, hab. session 10.60.61.7-0.10.40.40.90.70.60.70.70.60.90.7-1.20.30.8-1.3
Time in novel zone, hab. session 10.90.92.00.4-0.9-0.9-1.2-1.0-1.0-0.8-1.0-0.9-1.2-0.80.9-0.6-1.01.4
Total zone transitions, hab. session 12.43.45.41.5-2.1-2.1-1.0-1.9-1.9-2.1-2.0-2.2-1.4-2.00.1-2.3-2.21.3
Total locomotion distance, hab. session 10.40.61.9-0.3-0.9-0.90.6-0.4-0.5-0.5-0.6-0.8-0.1-0.80.9-1.0-1.40.7
Locomotion velocity, hab. session 10.50.82.2-0.2-1.0-1.00.4-0.6-0.6-0.7-0.8-0.9-0.5-1.01.0-1.1-1.51.0
Time in familiar zone, hab. session 21.92.03.0-0.71.51.51.01.41.41.51.61.61.21.4-0.91.51.7-1.6
Time in novel zone, hab. session 21.91.92.91.1-1.7-1.7-1.3-1.4-1.5-1.4-1.6-1.5-1.4-1.20.2-1.4-1.41.2
Total zone transitions, hab. session 20.10.10.6-0.20.20.20.80.30.30.20.30.20.60.2-0.3-0.10.1-0.5
Total locomotion distance, hab. session 20.71.03.2-1.40.80.81.81.11.01.11.00.81.20.80.50.50.2-0.6
Locomotion velocity, hab. session 20.70.93.1-1.50.70.71.81.00.91.00.90.81.10.70.60.40.0-0.5
Novel to familiar place preference ratio0.30.41.91.1-0.3-0.3-1.0-0.2-0.1-0.1-0.2-0.0-0.6-0.0-1.40.20.6-0.5
Novelty place preference0.30.32.10.9-0.2-0.2-0.80.00.00.20.10.2-0.40.2-1.40.30.8-0.7
Time in novel zone, NPP test0.40.42.91.0-0.2-0.2-0.8-0.0-0.00.10.00.2-0.30.3-1.70.20.8-0.8
Total zone transitions, NPP test0.60.91.90.8-1.1-1.1-0.2-1.0-1.0-1.1-1.0-1.1-0.2-1.0-0.3-1.4-1.10.3
Total locomotion distance, NPP test0.10.20.6-0.5-0.4-0.40.6-0.0-0.0-0.0-0.2-0.30.2-0.20.8-0.4-0.70.5
Locomotion velocity, NPP test0.10.20.7-0.7-0.2-0.20.70.10.10.1-0.1-0.20.3-0.20.8-0.3-0.60.4
Intraocular pressure0.30.52.8-0.40.20.2-0.7-0.2-0.0-0.2-0.4-0.1-1.0-0.41.70.3-0.61.4
Delta distance traveled before/after self-admin3.84.17.5-1.32.22.21.52.12.12.02.22.21.82.7-0.82.22.4-1.9
Delta ambulatory time before/after self-admin2.12.65.6-0.91.71.71.11.71.71.51.71.81.42.4-0.81.71.9-1.6
Parametrial fat weight0.20.41.0-1.00.90.90.40.60.60.40.60.60.5-0.10.90.60.0-0.0
Pavlov. Cond. lever latency1.21.52.81.7-1.5-1.5-0.8-1.4-1.6-1.3-1.2-1.3-0.2-1.1-1.4-1.6-0.7-0.1
Pavlov. Cond. magazine entry latency0.20.21.20.4-0.1-0.1-1.0-0.20.0-0.4-0.4-0.2-1.1-0.30.30.20.00.6
Pavlov. Cond. change in total contacts0.40.52.1-0.20.30.3-1.10.00.3-0.1-0.20.1-1.5-0.11.20.70.01.2
Pavlov. Cond. index score0.10.20.5-0.20.40.4-0.40.30.50.10.10.3-0.70.10.70.60.20.5
Pavlov. Cond. latency score0.20.30.8-0.50.70.7-0.20.50.70.30.30.5-0.60.30.80.90.40.4
Pavlov. Cond. lever contacts1.21.42.8-1.41.41.40.41.41.51.21.01.3-0.01.11.31.70.80.2
Pavlov. Cond. magazine entry number0.30.41.6-0.50.20.21.00.50.30.60.60.41.30.5-0.50.00.2-0.8
Pavlov. Cond. intertrial magazine entries1.11.32.7-1.61.21.21.01.21.21.21.01.11.01.21.31.20.60.1
Pavlov. Cond. lever-magazine prob. diff.0.10.20.7-0.00.30.3-0.60.10.4-0.1-0.10.1-0.9-0.10.70.40.00.6
Pavlov. Cond. response bias0.20.30.7-0.60.70.7-0.10.60.70.40.40.5-0.40.50.70.80.50.3
Pavlov. Cond. lever latency1.31.82.81.4-1.7-1.7-1.2-1.5-1.4-1.3-1.4-1.4-1.2-1.4-0.5-1.6-1.50.7
Pavlov. Cond. magazine entry latency0.60.71.5-0.81.21.20.70.90.90.70.90.90.60.60.41.01.1-0.3
Pavlov. Cond. change in total contacts0.20.32.1-0.70.50.50.20.0-0.0-0.2-0.00.0-0.20.01.40.2-0.00.9
Pavlov. Cond. index score0.71.01.8-1.21.31.31.11.01.00.91.01.00.80.70.71.11.0-0.3
Pavlov. Cond. latency score1.31.72.9-1.51.71.71.41.41.31.31.41.41.11.10.71.41.4-0.6
Pavlov. Cond. lever contacts1.41.92.8-1.51.71.71.31.51.41.31.51.51.21.50.61.61.5-0.6
Pavlov. Cond. magazine entry number0.91.11.91.1-1.4-1.4-1.1-1.1-1.1-0.9-1.1-1.1-0.8-0.9-0.6-1.1-1.10.4
Pavlov. Cond. intertrial magazine entries0.10.20.70.1-0.4-0.40.50.1-0.10.20.1-0.10.70.2-0.9-0.4-0.2-0.7
Pavlov. Cond. lever-magazine prob. diff.0.81.11.9-1.31.41.41.21.11.01.01.11.10.90.80.71.11.1-0.4
Pavlov. Cond. response bias0.40.61.0-0.81.01.00.60.80.80.60.80.80.40.70.61.01.0-0.1
Time in closed arm before self-admin1.62.15.50.4-1.0-1.0-2.2-1.1-1.0-1.2-1.3-1.0-2.4-1.51.8-0.2-1.12.3
Time in closed arm after self-admin1.01.05.2-0.6-0.4-0.4-0.6-0.5-0.5-0.4-0.7-0.6-1.3-0.82.3-0.1-1.22.0
Time in open arm before self-admin0.30.31.20.4-0.1-0.10.7-0.1-0.10.20.1-0.10.90.7-1.1-0.40.1-0.9
Time in open arm after self-admin0.10.10.30.00.10.10.30.10.10.10.20.20.60.2-0.40.00.5-0.4
Bone: periosteal estimation0.40.84.5-1.50.80.80.40.50.40.60.40.60.10.22.10.8-0.01.0
Bone: periosteal perimeter0.91.58.8-2.11.11.10.50.80.80.90.60.8-0.10.43.01.30.21.5
Bone: post-yield work0.71.01.91.4-0.9-0.9-0.5-1.1-1.1-1.1-0.9-1.1-0.3-1.2-1.0-1.3-0.9-0.1
Progressive ratio test 1 active lever presses0.30.31.50.40.30.30.50.20.10.20.30.30.70.7-1.20.00.8-1.0
Progressive ratio test 1 breakpoint0.20.31.40.50.20.20.40.10.00.10.20.20.50.6-1.2-0.00.8-0.9
Progressive ratio test 1 inactive lever presses0.10.10.5-0.50.40.40.70.30.20.30.30.30.50.50.30.20.3-0.1
Progressive ratio test 2 active lever presses0.91.02.0-1.11.01.01.41.01.01.11.01.01.21.40.30.80.9-0.6
Progressive ratio test 2 breakpoint0.70.81.6-1.00.80.81.20.90.80.90.80.81.01.30.30.70.8-0.5
Progressive ratio test 2 inactive lever presses0.71.12.7-1.50.90.91.61.11.01.11.00.91.31.20.70.80.6-0.4
Incentive Sensitization - Responses0.91.23.0-1.71.11.11.21.11.11.21.01.00.91.21.41.10.50.2
Incentive Sensitization - Breakpoint0.81.12.7-1.71.01.01.11.11.11.10.91.00.81.11.41.00.40.2
Sum of active levers in priming session hrs 5-60.10.10.6-0.30.20.20.10.30.30.30.10.3-0.30.80.50.60.50.3
Progressive ratio0.30.41.1-0.40.60.60.90.60.60.80.60.60.31.0-0.20.70.8-0.5
Food seeking constrained by brief footshock2.53.05.4-2.31.91.92.21.91.92.01.81.71.81.60.91.40.9-0.9
Seeking ratio, punishment vs. effort0.10.21.2-0.70.10.1-0.10.00.0-0.1-0.1-0.10.1-0.71.1-0.2-0.80.6
Retroperitoneal fat weight1.98.214.4-3.83.23.22.73.23.33.12.93.02.12.72.43.22.0-0.6
Reaction time number correct0.40.71.10.9-0.8-0.8-1.0-0.9-0.9-1.0-0.9-0.9-0.5-0.6-0.3-0.9-1.10.4
Reaction time mean minus median0.00.10.3-0.50.20.20.40.30.10.40.20.3-0.40.20.50.50.30.3
Reaction time mean minus median AUC0.10.20.4-0.50.30.30.60.60.40.60.40.50.10.50.10.50.5-0.2
Reaction time num false alarms0.10.10.50.4-0.2-0.2-0.6-0.2-0.2-0.2-0.3-0.1-0.70.40.10.20.40.5
Reaction time num false alarms AUC0.10.10.60.40.00.0-0.3-0.1-0.00.0-0.00.1-0.20.8-0.40.30.7-0.0
Reaction time trials correct on left0.40.71.10.9-0.8-0.8-1.0-0.9-0.9-1.0-0.9-0.9-0.5-0.6-0.3-0.9-1.10.4
Reaction time trials on left0.40.71.11.0-0.8-0.8-0.9-0.9-0.9-1.0-0.9-0.9-0.5-0.5-0.4-0.9-1.00.4
Reaction time mean0.20.32.11.00.00.0-0.3-0.3-0.3-0.2-0.0-0.0-0.10.0-1.5-0.10.7-0.8
Reaction time mean AUC0.20.31.81.0-0.1-0.1-0.4-0.4-0.5-0.3-0.1-0.2-0.2-0.0-1.3-0.20.5-0.7
Median of all reaction times0.40.64.41.30.00.0-0.4-0.3-0.3-0.20.10.00.10.1-2.1-0.20.9-1.3
Reaction time omissions0.20.31.11.0-0.4-0.4-0.3-0.5-0.6-0.4-0.4-0.4-0.40.2-0.9-0.30.1-0.2
Reaction time false alarm rate0.10.20.90.00.30.30.00.20.20.30.20.3-0.20.8-0.00.61.00.0
Reaction time premature initiation rate2.23.18.0-2.81.81.81.41.71.81.81.41.60.31.52.82.00.90.9
Reaction time premature initiations0.61.14.5-1.81.01.00.60.91.00.90.70.90.10.92.11.20.10.9
Std. dev. reaction times0.10.20.4-0.10.50.50.50.30.20.40.40.50.10.4-0.40.40.6-0.5
Reaction time trials completed0.40.71.11.0-0.8-0.8-0.9-0.9-0.9-1.0-0.9-0.9-0.5-0.5-0.4-0.9-1.00.4
Reaction time trials AUC0.20.40.80.8-0.6-0.6-0.8-0.7-0.8-0.8-0.7-0.7-0.3-0.4-0.3-0.7-0.90.3
Run reversals in cocaine runway, females0.20.20.60.10.20.20.30.40.30.40.30.30.50.6-0.80.20.6-0.7
Run reversals in cocaine runway, males1.01.01.60.4-1.0-1.0-0.8-1.0-1.0-1.0-1.1-1.1-1.1-0.80.8-0.9-1.11.3
Latency to leave start box in cocaine runway2.02.34.3-1.31.71.71.51.61.61.61.71.62.11.4-0.51.20.9-1.7
Latency to leave start box in cocaine runway, F4.34.98.2-1.22.32.32.02.32.32.22.42.32.72.2-1.71.82.0-2.9
Latency to leave start box in cocaine runway, M0.40.41.9-0.6-0.2-0.2-0.2-0.2-0.2-0.3-0.4-0.4-0.2-0.71.4-0.3-1.11.0
Std. dev. time between licks in bursts0.60.93.2-1.80.60.61.50.90.90.90.70.60.90.51.50.5-0.30.2
Total sessions with >9 infusions0.40.51.1-0.30.70.71.00.60.50.60.70.61.00.9-0.60.40.7-0.9
Short access day 1 total inactive lever presses4.05.37.6-2.12.42.42.82.52.42.42.52.42.72.4-0.22.02.0-2.0
Short access day 10 total inactive lever presses2.86.712.6-3.52.92.92.72.92.82.92.82.72.42.31.92.61.7-0.9
Short access day 1 total infusions1.21.62.9-0.81.31.31.71.21.11.21.31.21.71.5-0.60.91.3-1.5
Short access day 10 total infusions1.01.22.4-1.01.21.21.51.11.11.11.21.11.31.3-0.10.91.1-0.9
Short access total infusions0.81.02.5-0.91.11.11.61.00.91.01.01.01.31.2-0.10.71.0-0.9
Short access day 1 locomotion1.21.52.9-0.81.31.31.31.21.11.21.31.21.71.4-0.61.01.2-1.3
Short access day 10 total locomotion0.61.22.0-1.11.21.21.21.11.11.11.11.11.41.10.11.01.0-0.8
Short access total locomotion0.60.71.3-0.80.90.91.10.90.80.90.90.91.10.90.00.70.8-0.6
One hour access (0.3 mA shock)0.80.92.8-1.70.90.91.40.90.81.00.90.80.80.81.40.80.40.2
Compulsive drug intake0.00.00.20.1-0.1-0.1-0.5-0.1-0.0-0.1-0.1-0.1-0.5-0.20.20.1-0.20.2
One hour access (shock baseline)0.40.61.7-1.30.70.71.30.70.60.70.60.60.90.91.10.50.40.1
Social response proportion0.40.41.00.3-0.3-0.3-0.9-0.6-0.6-0.8-0.6-0.5-1.0-0.90.7-0.3-0.60.9
Social responses0.20.31.00.0-0.2-0.2-0.8-0.3-0.1-0.6-0.4-0.3-1.0-0.60.90.0-0.41.0
Social time0.60.82.4-0.20.80.80.80.80.80.61.00.81.30.6-1.20.40.7-1.5
Soleus weight1.13.14.6-1.71.91.91.91.91.81.81.91.92.11.9-0.11.61.5-1.5
Bone: stiffness0.10.20.60.5-0.2-0.2-0.3-0.7-0.8-0.5-0.4-0.4-0.3-0.7-0.1-0.6-0.40.1
Tibialis anterior weight0.10.20.8-0.20.40.40.20.40.20.50.40.50.50.9-0.20.60.4-0.3
Time to tail flick, vehicle, before self-admin1.31.43.3-1.81.21.21.21.41.41.21.21.20.91.01.21.30.7-0.1
Time to tail flick, vehicle, after self-admin0.50.71.2-1.11.01.00.80.90.90.80.90.90.80.90.70.90.4-0.2
Time to tail flick, test, before self-admin0.40.41.0-0.70.90.90.10.70.70.80.70.80.30.40.41.00.8-0.1
Time to tail flick, test, after self-admin3.43.64.5-1.62.12.11.62.02.12.02.12.12.11.9-0.41.82.0-1.8
Delta time to tail flick, vehicle, before/after SA0.50.51.21.1-0.7-0.7-0.8-0.9-0.8-0.8-0.7-0.7-0.4-0.4-0.6-0.8-0.60.1
Delta time to tail flick, test, before/after SA0.30.30.9-0.30.40.40.70.60.60.50.60.50.90.6-0.60.20.4-0.9
Tibia length1.33.66.61.8-1.9-1.9-0.9-2.4-2.5-2.4-2.0-2.3-0.8-2.1-0.3-2.6-1.80.9
Ambulatory time before self-admin0.30.41.30.8-0.6-0.6-0.5-0.6-0.6-0.6-0.5-0.5-0.2-1.2-0.8-0.7-0.5-0.1
Ambulatory time after self-admin0.30.31.00.20.50.5-0.00.50.50.30.50.60.30.7-0.90.61.0-0.8
Bone: tissue strength1.31.33.21.1-1.4-1.40.1-1.1-1.5-0.9-0.9-1.20.2-1.0-1.2-1.8-1.4-0.4
Total heroin consumption0.20.21.2-0.50.30.30.50.30.30.10.10.20.11.10.80.30.60.4
Bone: trabecular number0.61.02.31.0-1.3-1.3-1.3-1.2-1.5-0.7-1.1-1.0-1.2-0.3-0.2-0.7-0.30.9
Bone: trabecular spacing1.72.33.8-1.71.71.71.91.71.91.41.61.51.71.00.31.20.9-1.2
Bone: trabecular thickness0.30.41.4-0.2-0.3-0.3-0.7-0.4-0.4-0.4-0.5-0.4-0.8-0.41.2-0.1-0.61.2
Bone: trabecular tissue density1.52.23.71.6-1.4-1.4-1.1-1.8-1.7-1.9-1.6-1.7-1.2-1.8-0.2-1.8-1.50.8
Water consumed over 24 hours0.20.31.5-0.70.40.41.20.2-0.00.50.50.31.10.30.1-0.10.2-0.5
Number of responses in last shaping day0.20.20.80.7-0.3-0.30.1-0.3-0.4-0.3-0.2-0.30.30.1-0.9-0.5-0.3-0.5