Hub : Genes

Plxna2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Plxna2 0.06 0.06 2.0e-04 0.04 0.04 0.05 0.04 3.7e-04 1.6e-04 6.2e-05 4.3e-04
2 IC mRNA stability Plxna2 0.15 0.12 8.6e-05 0.09 0.08 0.04 0.06 2.1e-04 3.7e-04 8.7e-03 1.5e-03
3 Eye gene expression Plxna2 0.33 0.22 2.1e-04 0.29 0.29 0.3 0.28 2.2e-05 2.5e-05 1.5e-05 3.0e-05
4 NAcc mRNA stability Plxna2 0.05 0.04 4.2e-08 0.04 0.05 0.04 0.04 4.3e-07 1.6e-07 1.2e-06 8.9e-07
5 OFC mRNA stability Plxna2 0.34 0.23 2.7e-05 0.11 0.17 0.12 0.14 1.3e-03 8.3e-05 7.7e-04 3.5e-04
6 pVTA gene expression Plxna2 0.09 0.08 3.9e-06 0.07 0.07 0.07 0.07 1.6e-06 3.0e-06 3.3e-06 2.6e-06
7 Brain gene expression Plxna2 0.04 0.04 3.4e-04 0.01 0.02 0.01 0.01 1.3e-02 3.4e-03 2.1e-02 1.9e-02
8 LHb gene expression Plxna2 0.12 0.11 7.8e-03 0.06 0.06 0.04 0.05 1.3e-02 1.8e-02 5.0e-02 2.7e-02
9 BLA mRNA stability Plxna2 0.11 0.08 5.3e-05 0.05 0.05 0.04 0.05 9.8e-04 8.2e-04 5.4e-03 1.6e-03
10 PL mRNA stability Plxna2 0.06 0.04 2.7e-08 0.06 0.07 0.06 0.06 9.4e-07 4.4e-08 2.8e-07 3.8e-07
11 NAcc gene expression Plxna2 0.03 0.02 8.6e-06 0.03 0.03 0.02 0.03 8.5e-05 4.9e-05 6.8e-04 7.6e-05
12 Brain mRNA stability Plxna2 0.12 0.08 3.5e-13 0.07 0.12 0.1 0.09 3.4e-07 1.4e-11 1.8e-09 7.1e-09
13 Adipose mRNA stability Plxna2 0.02 0.02 2.8e-03 0.02 0.01 0.01 0.01 5.9e-03 9.6e-03 3.8e-02 1.6e-02
14 IC gene expression Plxna2 0.11 0.11 4.0e-03 0.04 0.03 0.02 0.03 1.3e-02 1.7e-02 4.0e-02 3.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.00.00.4-0.6-0.20.1-0.1-0.1-0.2-0.1-0.2-0.1-0.1-0.1-0.1-0.1-0.1
Area under the delay curve0.10.10.20.10.4-0.40.30.40.50.40.40.30.30.30.30.40.3
BMI with tail0.00.20.60.2-0.40.3-0.4-0.3-0.4-0.3-0.4-0.4-0.4-0.4-0.4-0.4-0.7
BMI without tail1.13.34.9-2.2-1.81.7-1.7-1.6-1.7-1.7-1.8-1.7-1.7-1.8-1.8-1.8-2.1
Body weight3.414.721.0-2.8-3.83.8-3.9-3.8-3.8-3.8-3.8-3.9-3.8-3.9-4.0-3.8-4.6
Weight adjusted by age2.13.24.7-2.2-1.81.8-1.6-1.7-1.9-1.7-1.8-1.7-1.7-1.7-1.7-1.9-1.4
Bone surface0.61.12.0-1.4-1.20.9-1.1-1.1-1.2-1.0-1.1-1.0-1.0-1.0-1.0-0.9-1.0
Bone volume0.30.51.6-1.3-0.80.7-0.6-0.6-0.8-0.6-0.7-0.6-0.7-0.7-0.7-0.6-0.6
Breakpoint value in progressive ratio session3.54.24.7-2.1-2.02.0-2.0-2.0-2.0-2.1-2.2-2.0-2.0-2.1-2.1-2.2-1.8
Number of licking bursts0.00.10.1-0.2-0.20.2-0.2-0.3-0.2-0.2-0.3-0.2-0.2-0.2-0.2-0.2-0.2
Context. condit. distance diff. score0.30.30.8-0.9-0.60.5-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.5-0.5-0.6-0.4
Locomotion velocity, session 13.63.94.7-0.9-2.01.9-2.2-2.2-2.0-2.1-2.1-2.1-2.1-2.0-2.0-1.9-2.0
Locomotion distance, session 13.44.34.7-1.7-2.12.0-2.2-2.2-2.1-2.1-2.1-2.1-2.1-2.1-2.1-2.0-2.1
Locomotion velocity, session 21.11.31.6-0.7-1.11.2-1.1-1.1-1.1-1.2-1.2-1.1-1.1-1.1-1.1-1.2-1.0
Locomotion distance, session 21.72.33.1-1.6-1.61.6-1.4-1.5-1.6-1.5-1.8-1.4-1.5-1.5-1.5-1.6-1.2
Locomotion velocity, session 31.41.63.8-1.9-1.31.2-1.1-1.1-1.3-1.1-1.1-1.1-1.2-1.2-1.2-1.2-1.0
Locomotion distance, session 30.20.22.8-1.70.1-0.20.30.30.10.30.20.30.20.20.20.20.2
Stereotopy head waving bouts, day 32.22.63.3-0.4-1.71.7-1.7-1.8-1.7-1.8-1.7-1.7-1.7-1.6-1.6-1.7-1.3
Stereotopy head waving duration, day 31.82.12.80.1-1.61.6-1.5-1.7-1.6-1.6-1.6-1.5-1.5-1.5-1.4-1.6-1.0
Locomotion velocity, session 70.10.11.6-1.3-0.10.20.20.2-0.10.1-0.30.10.0-0.0-0.1-0.20.2
Locomotion distance, session 70.60.72.5-1.60.4-0.41.10.90.40.80.40.90.80.70.70.41.3
Stereotopy head waving bouts, day 71.61.82.60.2-1.31.2-1.6-1.5-1.3-1.4-1.1-1.5-1.4-1.3-1.3-1.1-1.6
Stereotopy head waving duration, day 71.01.21.90.6-1.00.9-1.4-1.3-1.0-1.2-0.9-1.3-1.2-1.1-1.0-0.9-1.4
Locomotion velocity, session 80.40.40.6-0.7-0.60.6-0.7-0.8-0.6-0.7-0.7-0.7-0.7-0.6-0.6-0.7-0.4
Locomotion distance, session 81.82.74.0-2.0-1.71.6-1.6-1.6-1.7-1.6-1.7-1.6-1.6-1.6-1.6-1.7-1.3
Degree of sensitization distance0.30.30.70.60.4-0.30.60.50.40.50.30.60.50.50.50.20.8
Degree of sensitization stereotypy0.10.10.80.9-0.0-0.1-0.3-0.2-0.0-0.10.1-0.2-0.1-0.1-0.10.1-0.6
Conditioned locomotion0.50.61.51.20.7-0.80.70.70.60.70.70.70.70.70.80.80.8
Cocaine response after cond. corrected0.20.21.31.20.6-0.6-0.00.10.60.30.60.10.20.30.30.6-0.2
Cocaine response after cond. not corrected0.20.21.81.30.4-0.4-0.2-0.10.40.10.3-0.10.00.10.10.4-0.3
Cocaine response before conditioning0.10.10.10.1-0.30.3-0.1-0.2-0.4-0.3-0.4-0.2-0.2-0.2-0.2-0.3-0.0
Saline control response1.21.52.1-0.11.2-1.21.51.41.21.31.11.41.31.31.31.21.3
Bone: connectivity density0.40.60.8-0.9-0.90.7-0.9-0.9-0.9-0.8-0.8-0.8-0.8-0.8-0.7-0.7-0.7
Bone: cortical apparent density0.10.10.2-0.40.2-0.20.30.20.20.20.20.30.20.20.20.20.3
Bone: cortical area1.42.22.9-1.7-1.51.5-1.4-1.4-1.5-1.4-1.6-1.4-1.4-1.4-1.5-1.4-1.4
Bone: cortical porosity0.20.20.40.70.5-0.50.40.40.50.40.30.40.40.40.40.40.4
Bone: cortical porosity0.30.30.40.50.6-0.60.60.60.60.60.40.60.60.60.60.60.6
Bone: cortical thickness0.81.31.6-1.1-1.21.2-1.1-1.2-1.2-1.2-1.3-1.1-1.1-1.1-1.1-1.1-1.1
Bone: cortical thickness3.54.26.5-2.5-2.12.1-1.9-2.0-2.1-2.0-2.1-2.0-2.0-2.0-2.0-2.0-1.7
Bone: cortical tissue density0.10.10.2-0.40.3-0.30.30.30.30.30.20.30.30.30.30.30.4
Condit. Reinf. active minus inactive responses0.10.10.4-0.6-0.20.2-0.1-0.1-0.2-0.1-0.3-0.1-0.1-0.2-0.2-0.2-0.2
Condit. Reinf. active-inactive response ratio1.01.11.31.01.1-1.11.11.11.11.11.01.01.11.01.01.10.9
Condit. Reinf. active responses0.81.03.3-1.8-1.01.0-0.8-0.8-1.0-0.8-1.1-0.8-0.9-0.9-1.0-1.0-0.9
Condit. Reinf. inactive responses2.53.16.4-2.5-1.81.8-1.5-1.6-1.8-1.6-1.8-1.6-1.7-1.7-1.7-1.8-1.4
Incentive salience index mean0.20.31.4-1.2-0.50.5-0.3-0.3-0.5-0.4-0.6-0.4-0.4-0.5-0.5-0.5-0.4
Condit. Reinf. lever presses0.70.91.7-1.3-1.01.0-0.8-0.8-1.0-0.9-1.0-0.9-0.9-0.9-1.0-1.0-0.9
Condit. Reinf. active minus inactive responses0.30.40.80.30.6-0.50.90.80.60.70.50.80.70.70.60.50.7
Condit. Reinf. active-inactive response ratio0.80.91.61.31.0-0.81.00.90.90.90.90.90.90.90.90.90.8
Condit. Reinf. active responses0.10.10.3-0.60.10.00.50.40.10.3-0.00.40.30.20.20.00.4
Condit. Reinf. inactive responses0.71.03.3-1.8-1.01.0-0.6-0.7-1.0-0.8-1.0-0.7-0.8-0.9-0.9-1.0-0.7
Condit. Reinf. lever presses0.40.61.8-1.3-0.70.9-0.4-0.5-0.7-0.6-0.9-0.5-0.6-0.7-0.7-0.9-0.4
Condit. Reinf. lever reinforcers received0.00.10.3-0.5-0.00.10.40.2-0.00.1-0.10.20.10.10.1-0.10.3
Conditioned reinforcement - actives0.71.21.4-1.1-1.01.0-1.2-1.1-1.0-1.1-1.0-1.2-1.1-1.1-1.1-1.0-1.1
Conditioned reinforcement - inactives4.05.87.2-2.7-2.62.6-2.3-2.4-2.6-2.4-2.4-2.3-2.4-2.4-2.4-2.4-2.0
Conditioned locomotion3.14.04.3-1.7-2.02.0-2.1-2.1-2.0-2.1-2.1-2.1-2.0-2.0-2.0-2.1-1.9
Patch foraging indifference point 0 sec0.40.71.00.3-0.90.7-0.9-0.9-0.9-0.8-0.7-0.8-0.8-0.8-0.8-0.7-1.0
Patch foraging indifference point AUC0.81.12.10.41.0-1.01.31.11.01.10.81.21.11.11.10.91.4
Delay disc. indifference point, 0s delay1.71.92.5-0.9-1.51.6-1.3-1.3-1.4-1.4-1.4-1.3-1.3-1.4-1.4-1.6-1.2
Delay disc. indifference point, 16s delay0.60.71.10.81.0-0.90.70.81.10.80.90.70.80.80.80.90.5
Delay disc. indifference point, 2s delay0.00.00.3-0.6-0.00.00.20.1-0.00.1-0.20.10.10.10.1-0.00.4
Delay disc. indifference point, 24s delay2.42.74.10.91.9-1.91.41.61.91.72.01.51.61.61.62.01.2
Delay disc. indifference point, 4s delay0.00.00.30.40.0-0.1-0.20.00.00.00.2-0.1-0.0-0.1-0.10.1-0.6
Delay disc. indifference point, 8s delay0.30.30.9-0.10.6-0.50.70.60.60.50.40.60.60.60.60.50.9
Indifference point function ln k1.52.63.6-0.7-1.61.6-1.9-1.8-1.6-1.7-1.5-1.8-1.7-1.7-1.6-1.5-1.7
Indifference point function log k1.52.63.6-0.7-1.61.6-1.9-1.8-1.6-1.7-1.5-1.8-1.7-1.7-1.6-1.5-1.7
Patch foraging total patch changes 0 sec0.30.50.90.4-0.80.6-0.8-0.8-0.8-0.7-0.7-0.8-0.7-0.7-0.7-0.6-1.0
Patch foraging total patch changes 12 sec0.30.40.80.5-0.60.7-0.5-0.6-0.6-0.6-0.9-0.5-0.6-0.6-0.6-0.8-0.6
Patch foraging total patch changes 18 sec0.50.71.1-0.4-1.01.0-0.7-0.8-1.0-0.8-0.9-0.7-0.8-0.8-0.8-1.0-0.7
Patch foraging total patch changes 24 sec0.00.10.2-0.5-0.40.3-0.1-0.1-0.4-0.2-0.4-0.1-0.2-0.2-0.2-0.3-0.1
Patch foraging total patch changes 6 sec0.00.00.00.1-0.20.10.10.0-0.2-0.0-0.20.00.0-0.0-0.0-0.10.0
Patch foraging time to switch 0 sec0.71.42.9-0.5-1.21.1-1.3-1.2-1.1-1.2-1.0-1.3-1.2-1.2-1.3-1.0-1.7
Patch foraging water rate 0 sec0.30.71.31.10.8-0.80.80.70.70.70.60.80.80.80.90.61.1
Patch foraging water rate 12 sec0.40.81.91.40.8-0.80.90.80.80.80.70.90.80.80.90.81.1
Patch foraging water rate 18 sec0.10.20.40.2-0.50.4-0.4-0.5-0.5-0.4-0.6-0.4-0.4-0.4-0.4-0.6-0.3
Patch foraging water rate 24 sec0.10.20.20.3-0.40.5-0.4-0.5-0.4-0.5-0.5-0.4-0.4-0.4-0.4-0.4-0.2
Patch foraging water rate 6 sec0.00.00.10.10.0-0.00.10.00.0-0.0-0.30.10.00.00.0-0.10.2
Seeking ratio, delayed vs. immediate footshock3.03.64.61.71.9-1.92.12.11.92.01.72.12.01.91.91.71.8
Distance traveled before self-admin2.12.73.6-1.8-1.51.7-1.5-1.7-1.5-1.7-1.9-1.6-1.7-1.6-1.6-1.9-1.1
Distance traveled after self-admin3.74.65.7-1.9-2.22.2-2.0-2.2-2.2-2.2-2.4-2.1-2.1-2.1-2.1-2.4-1.5
Extensor digitorum longus weight0.00.10.3-0.5-0.30.3-0.2-0.2-0.3-0.2-0.4-0.2-0.2-0.3-0.3-0.3-0.3
Bone: elastic displacement0.10.10.2-0.2-0.20.3-0.4-0.5-0.2-0.4-0.5-0.4-0.4-0.3-0.3-0.3-0.2
Bone: elastic work0.30.40.7-0.2-0.50.6-0.7-0.7-0.5-0.7-0.8-0.6-0.7-0.6-0.6-0.6-0.5
Bone: endosteal estimation0.00.00.1-0.1-0.10.1-0.1-0.1-0.1-0.1-0.0-0.1-0.1-0.1-0.1-0.0-0.2
Bone: endosteal perimeter0.10.10.4-0.6-0.40.3-0.3-0.2-0.4-0.3-0.3-0.3-0.3-0.4-0.4-0.3-0.5
Epididymis fat weight0.41.42.00.0-1.21.1-1.3-1.3-1.1-1.2-1.2-1.3-1.2-1.2-1.2-1.1-1.4
Delta time in closed arm before/after self-admin0.10.10.6-0.70.0-0.1-0.3-0.20.0-0.10.2-0.2-0.2-0.1-0.10.10.0
Delta time in open arm before/after self-admin0.10.10.4-0.30.4-0.20.60.60.40.40.20.50.50.30.30.10.3
Diff in mean of infusions in LGA sessions0.91.11.4-1.1-1.01.1-1.0-1.0-1.0-1.1-1.2-1.0-1.0-1.1-1.1-1.2-0.8
Delay discount exponential model param0.20.30.4-0.3-0.60.6-0.5-0.5-0.6-0.5-0.6-0.5-0.5-0.5-0.5-0.6-0.4
Extinction: sum of active levers before priming6.87.515.7-4.0-2.62.7-2.5-2.6-2.6-2.7-2.7-2.6-2.7-2.7-2.6-2.8-2.3
Active lever presses in extinction session 614.414.319.4-4.4-3.83.8-3.8-3.8-3.8-3.8-3.6-3.8-3.8-3.8-3.7-3.6-3.4
Bone: final force0.71.11.7-0.1-1.11.0-1.1-1.1-1.1-1.1-1.0-1.1-1.0-1.1-1.1-1.0-1.3
Bone: final moment0.71.21.6-0.5-1.21.0-1.1-1.1-1.2-1.1-1.1-1.1-1.1-1.1-1.1-1.0-1.3
Food consumed during 24 hour testing period0.81.11.3-0.5-1.01.0-1.2-1.1-1.1-1.1-1.1-1.1-1.1-1.0-1.0-1.0-1.1
Glucose0.30.50.70.40.8-0.80.60.60.70.70.80.70.70.70.70.70.6
Heart weight0.91.31.8-0.9-1.11.3-1.1-1.1-1.1-1.1-1.2-1.1-1.1-1.2-1.2-1.2-1.1
Delay discount hyperbolic model param0.10.10.20.1-0.40.3-0.3-0.3-0.4-0.3-0.3-0.3-0.3-0.3-0.3-0.4-0.3
Intermittent access intake day 1-15 change0.00.10.30.60.1-0.20.10.10.30.10.20.20.20.20.30.20.5
Intermittent access intake escalation0.10.10.30.60.2-0.30.10.10.40.20.40.20.20.30.40.40.5
Intermittent access intake escalation 20.00.00.40.70.0-0.1-0.0-0.10.1-0.00.10.00.00.10.10.10.3
Intermitt. access day 1 inactive lever presses0.10.30.5-0.3-0.70.7-0.4-0.5-0.7-0.5-0.6-0.5-0.5-0.6-0.6-0.6-0.5
Intermitt. access day 15 inactive lever presses0.30.71.3-0.9-1.11.1-0.7-0.7-1.1-0.8-0.8-0.7-0.7-0.8-0.9-0.8-0.7
Intermitt. access escalation Index1.01.51.91.41.2-1.31.21.31.21.31.21.21.31.21.21.20.8
Intermittent access day 1 total infusions1.72.85.6-2.4-1.61.6-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.3
Intermittent access day 15 total infusions0.60.91.3-1.1-1.00.9-1.1-1.1-0.9-1.0-0.8-1.0-1.0-0.9-0.9-0.8-0.5
Intermittent access terminal intake (last 3 days)1.52.03.0-1.7-1.51.4-1.5-1.6-1.4-1.5-1.4-1.4-1.5-1.4-1.3-1.4-0.9
Intermittent access total infusions1.01.22.1-1.4-1.11.1-1.2-1.2-1.0-1.1-1.0-1.1-1.1-1.1-1.0-1.0-0.7
Intermittent access day 1 locomotion3.13.94.3-2.1-1.91.9-2.0-2.0-1.9-2.0-2.0-2.0-2.0-2.0-2.0-2.0-1.8
Intermittent access day 15 total locomotion3.05.56.1-2.0-2.42.4-2.4-2.5-2.3-2.4-2.5-2.4-2.4-2.4-2.3-2.5-2.0
Intermittent access total locomotion2.73.24.0-2.0-1.81.8-1.9-1.9-1.7-1.8-1.8-1.8-1.8-1.8-1.8-1.8-1.6
Intermittent access standard deviation0.20.42.1-1.5-0.70.7-0.5-0.6-0.6-0.6-0.5-0.5-0.5-0.5-0.4-0.50.2
Left kidney weight1.98.911.3-2.1-3.02.9-3.1-3.0-3.0-3.0-2.8-3.1-3.1-3.0-3.1-2.9-3.4
Right kidney weight3.315.017.7-2.8-4.03.8-4.1-4.0-3.9-3.9-3.8-4.0-4.0-3.9-3.9-3.8-4.2
Cocaine induced anxiety0.71.02.1-1.5-1.01.0-0.8-0.9-1.0-0.9-1.1-0.9-0.9-1.0-1.0-1.1-0.8
Post-drug Anxiety0.20.20.4-0.0-0.60.5-0.4-0.4-0.6-0.5-0.6-0.4-0.4-0.5-0.5-0.6-0.4
Baseline Anxiety2.32.78.02.81.5-1.61.41.41.51.51.61.51.51.61.61.61.4
Tail length2.610.116.0-4.0-3.13.0-3.1-3.0-3.1-3.0-2.9-3.1-3.1-3.1-3.2-3.0-3.6
Length with tail5.222.827.5-4.6-4.74.7-4.8-4.7-4.7-4.7-4.6-4.8-4.8-4.8-4.9-4.7-5.2
Length without tail2.68.411.0-1.8-2.82.8-3.1-3.0-2.9-3.0-2.8-3.1-3.0-3.0-3.0-2.8-3.3
Times rat made contact with spout0.20.20.40.5-0.30.4-0.5-0.4-0.4-0.4-0.4-0.5-0.4-0.4-0.4-0.4-0.7
Lifetime Intake1.41.72.2-1.5-1.31.3-1.4-1.4-1.2-1.4-1.2-1.4-1.4-1.3-1.3-1.2-1.0
Liver weight, left0.81.31.6-1.0-1.21.1-1.1-1.1-1.1-1.1-1.2-1.1-1.1-1.1-1.1-1.3-1.0
Liver weight, right0.00.10.30.0-0.10.1-0.4-0.3-0.0-0.20.0-0.3-0.2-0.2-0.10.0-0.5
Locomotor activity1.42.22.6-1.1-1.51.5-1.6-1.6-1.5-1.6-1.4-1.5-1.5-1.5-1.4-1.4-1.4
Locomotor testing distance0.91.51.9-0.9-1.31.4-1.2-1.3-1.3-1.3-1.3-1.2-1.3-1.2-1.2-1.2-1.1
Locomotor testing rearing0.00.10.20.1-0.40.5-0.0-0.2-0.4-0.2-0.4-0.1-0.2-0.2-0.2-0.40.1
Locomotion in novel chamber0.50.60.70.80.7-0.80.80.90.70.80.80.80.80.80.80.80.7
Locomotion in novel chamber post-restriction0.40.61.1-0.00.5-0.80.80.80.50.80.90.80.80.80.81.01.0
Fecal boli incidents, locomotor time 10.60.81.31.10.9-1.00.90.81.00.90.90.90.80.90.90.90.7
Change in fecal boli incidents, locomotor task0.30.30.50.3-0.50.6-0.4-0.5-0.6-0.6-0.7-0.5-0.5-0.5-0.5-0.7-0.2
Time >=10cm from walls, locomotor time 10.40.40.8-0.1-0.40.6-0.6-0.6-0.4-0.7-0.9-0.6-0.6-0.6-0.6-0.8-0.7
Bouts of movement, locomotor time 11.31.45.72.41.3-1.30.81.01.31.01.20.81.01.01.01.20.1
Total resting periods, locomotor time 11.21.33.01.71.3-1.40.91.01.21.11.20.91.01.11.01.20.3
Rest time, locomotor task time 10.10.10.4-0.20.1-0.10.40.30.10.30.40.40.30.30.40.30.7
Distance moved, locomotor task time 11.72.52.8-1.5-1.61.6-1.7-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.5-1.5
Vertical activity count, locomotor time 10.00.00.20.50.1-0.2-0.1-0.00.10.00.0-0.10.0-0.0-0.10.1-0.3
Time >=10cm from walls, locomotor time 20.50.71.4-0.8-0.60.7-0.9-0.8-0.7-0.8-0.8-0.9-0.9-0.8-0.8-0.7-1.2
Bouts of movement, locomotor time 20.30.51.00.51.0-0.90.50.61.00.70.80.60.60.70.70.90.5
Total resting periods, locomotor time 20.10.20.50.30.7-0.60.20.30.70.40.60.30.40.40.40.60.2
Rest time, locomotor task time 20.50.71.81.30.7-0.80.70.70.70.81.10.70.80.80.80.80.5
Distance moved, locomotor task time 23.13.74.0-1.6-2.02.0-1.9-1.9-2.0-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.9
Vertical activity count, locomotor time 20.30.50.7-0.4-0.70.8-0.6-0.6-0.7-0.7-0.8-0.6-0.6-0.7-0.7-0.8-0.6
Light reinforcement 10.10.21.31.10.3-0.40.30.30.30.40.50.40.30.40.50.50.3
Light reinforcement 20.10.21.21.10.3-0.30.10.10.30.20.40.20.20.30.40.50.3
Bone: marrow area0.00.00.00.0-0.0-0.1-0.00.0-0.00.00.1-0.0-0.00.0-0.00.1-0.1
Bone: maximum diameter0.40.81.3-1.1-0.90.9-0.8-0.8-0.9-0.8-0.9-0.8-0.8-0.9-0.9-0.8-0.9
Bone: maximum force1.52.73.1-1.2-1.71.6-1.7-1.8-1.7-1.7-1.7-1.7-1.7-1.7-1.6-1.6-1.7
Bone: maximum moment1.83.23.5-1.6-1.91.8-1.8-1.9-1.9-1.8-1.9-1.8-1.8-1.8-1.8-1.8-1.7
Mean time between licks in bursts0.00.00.00.10.10.10.10.10.10.1-0.10.10.10.0-0.0-0.10.0
Mean num. licks in bursts0.00.00.10.2-0.10.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.2
Cd content in liver3.84.34.9-2.2-2.22.1-1.9-1.9-2.2-2.0-2.2-2.0-2.0-2.1-2.1-2.1-2.0
Co content in liver0.50.60.8-0.0-0.80.8-0.8-0.9-0.8-0.9-0.8-0.8-0.8-0.8-0.7-0.8-0.6
Cu content in liver5.76.810.43.22.6-2.62.52.52.62.62.62.52.62.62.62.72.2
Fe content in liver5.66.87.22.72.7-2.62.62.62.72.62.72.62.62.62.62.72.3
K content in liver0.70.70.90.40.8-0.80.80.80.80.80.90.80.80.80.90.80.9
Mg content in liver0.20.20.2-0.4-0.40.4-0.4-0.5-0.4-0.4-0.4-0.4-0.4-0.4-0.3-0.4-0.2
Mn content in liver0.10.10.5-0.7-0.20.2-0.2-0.2-0.2-0.2-0.4-0.2-0.2-0.2-0.2-0.3-0.1
Na content in liver2.62.73.21.41.8-1.81.51.61.81.71.81.61.61.71.71.81.5
Rb content in liver0.70.81.50.40.7-0.71.00.90.70.90.91.00.90.90.90.81.2
Se content in liver0.30.40.70.1-0.50.6-0.7-0.7-0.5-0.7-0.8-0.7-0.7-0.6-0.6-0.7-0.6
Sr content in liver0.40.30.5-0.00.6-0.50.70.70.60.60.30.60.60.60.50.60.6
Zn content in liver4.24.75.4-0.8-2.32.2-2.3-2.3-2.3-2.3-2.2-2.3-2.2-2.2-2.2-2.1-2.2
Bone: minimum diameter0.10.22.2-1.5-0.20.20.10.1-0.2-0.0-0.3-0.0-0.1-0.1-0.2-0.1-0.1
Time in familiar zone, hab. session 10.10.10.5-0.70.2-0.20.40.40.20.30.20.40.30.30.30.20.6
Time in novel zone, hab. session 13.13.13.6-0.9-1.81.8-1.8-1.8-1.8-1.8-1.8-1.8-1.8-1.8-1.8-1.8-1.9
Total zone transitions, hab. session 14.15.75.9-2.2-2.42.4-2.4-2.4-2.4-2.4-2.4-2.4-2.4-2.4-2.4-2.4-2.3
Total locomotion distance, hab. session 14.15.86.5-1.6-2.52.4-2.5-2.5-2.5-2.5-2.4-2.5-2.5-2.4-2.4-2.4-2.2
Locomotion velocity, hab. session 12.02.83.5-0.7-1.71.6-1.9-1.9-1.7-1.8-1.6-1.8-1.8-1.7-1.7-1.6-1.7
Time in familiar zone, hab. session 20.50.50.6-0.8-0.70.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.8
Time in novel zone, hab. session 20.00.00.40.60.1-0.10.00.10.10.10.00.00.10.0-0.00.1-0.2
Total zone transitions, hab. session 21.52.02.5-0.5-1.51.4-1.4-1.4-1.5-1.4-1.6-1.4-1.4-1.4-1.5-1.4-1.6
Total locomotion distance, hab. session 21.92.52.8-0.6-1.71.6-1.6-1.6-1.7-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.7
Locomotion velocity, hab. session 21.11.51.8-0.2-1.31.3-1.3-1.3-1.3-1.3-1.3-1.3-1.2-1.3-1.3-1.3-1.4
Novel to familiar place preference ratio0.30.31.31.10.6-0.60.30.50.60.50.60.40.50.50.50.70.0
Novelty place preference0.10.21.21.10.3-0.40.10.20.30.30.30.10.20.20.20.4-0.3
Time in novel zone, NPP test0.10.11.01.00.2-0.30.00.20.20.20.30.10.20.20.10.3-0.3
Total zone transitions, NPP test3.75.36.2-1.4-2.32.3-2.4-2.4-2.3-2.4-2.4-2.4-2.3-2.3-2.4-2.3-2.5
Total locomotion distance, NPP test2.43.34.0-1.0-1.91.8-1.9-1.9-1.9-1.9-1.8-1.9-1.8-1.9-1.9-1.8-2.0
Locomotion velocity, NPP test2.43.34.2-0.9-1.91.8-1.9-1.9-1.9-1.9-1.8-1.9-1.8-1.9-1.9-1.8-2.1
Intraocular pressure0.00.10.80.9-0.1-0.00.0-0.0-0.00.0-0.10.00.00.10.10.10.1
Delta distance traveled before/after self-admin0.10.10.30.5-0.50.4-0.3-0.3-0.5-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.6
Delta ambulatory time before/after self-admin0.10.11.01.00.1-0.30.20.30.10.30.50.30.30.30.30.50.0
Parametrial fat weight0.10.21.10.3-0.20.3-0.4-0.3-0.1-0.3-0.3-0.4-0.3-0.4-0.5-0.3-1.1
Pavlov. Cond. lever latency0.10.10.50.70.4-0.30.10.10.40.20.30.20.20.30.30.30.3
Pavlov. Cond. magazine entry latency0.91.22.4-1.5-1.11.1-0.9-0.9-1.1-0.9-1.1-1.0-1.0-1.1-1.1-1.0-1.2
Pavlov. Cond. change in total contacts0.10.10.4-0.6-0.20.1-0.00.1-0.2-0.0-0.2-0.1-0.0-0.1-0.2-0.0-0.4
Pavlov. Cond. index score0.00.00.3-0.5-0.10.00.20.2-0.10.1-0.00.10.10.0-0.00.0-0.1
Pavlov. Cond. latency score0.00.00.3-0.5-0.0-0.10.20.3-0.00.20.10.10.20.10.00.1-0.1
Pavlov. Cond. lever contacts0.00.00.1-0.3-0.20.10.10.1-0.2-0.0-0.10.0-0.0-0.1-0.1-0.1-0.1
Pavlov. Cond. magazine entry number0.70.92.31.51.0-1.00.70.71.00.80.90.80.80.91.00.91.0
Pavlov. Cond. intertrial magazine entries0.00.00.3-0.5-0.10.1-0.0-0.1-0.1-0.1-0.2-0.0-0.1-0.0-0.0-0.10.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.6-0.40.3-0.2-0.2-0.4-0.2-0.4-0.3-0.3-0.3-0.4-0.3-0.5
Pavlov. Cond. response bias1.11.42.2-1.5-1.21.2-1.0-1.0-1.2-1.1-1.3-1.1-1.1-1.2-1.2-1.2-1.2
Pavlov. Cond. lever latency1.41.94.52.11.3-1.51.11.21.41.31.51.21.31.31.31.51.1
Pavlov. Cond. magazine entry latency0.40.41.00.3-0.60.6-0.7-0.6-0.7-0.6-0.7-0.7-0.6-0.7-0.7-0.6-1.0
Pavlov. Cond. change in total contacts0.10.10.30.10.3-0.30.50.50.30.40.30.50.50.40.40.30.4
Pavlov. Cond. index score0.71.01.2-0.9-1.01.1-0.9-0.9-1.1-1.0-1.1-0.9-1.0-1.0-1.0-1.0-1.1
Pavlov. Cond. latency score0.60.81.1-0.9-0.90.9-0.8-0.8-0.9-0.8-1.0-0.8-0.8-0.9-0.9-0.9-1.0
Pavlov. Cond. lever contacts1.42.04.5-2.1-1.31.5-1.1-1.2-1.4-1.3-1.5-1.2-1.3-1.3-1.4-1.5-1.1
Pavlov. Cond. magazine entry number0.10.10.2-0.10.4-0.40.30.30.40.30.50.30.30.30.40.30.5
Pavlov. Cond. intertrial magazine entries0.30.50.7-0.20.8-0.60.70.70.80.70.70.70.70.70.60.60.7
Pavlov. Cond. lever-magazine prob. diff.0.60.71.0-0.9-0.90.9-0.8-0.8-0.9-0.8-1.0-0.8-0.8-0.9-0.9-0.9-0.9
Pavlov. Cond. response bias1.31.72.2-1.1-1.31.5-1.1-1.2-1.4-1.3-1.5-1.2-1.3-1.3-1.3-1.4-1.2
Time in closed arm before self-admin0.30.43.21.80.3-0.50.40.40.30.40.30.40.50.40.40.30.1
Time in closed arm after self-admin0.20.20.80.9-0.40.1-0.5-0.5-0.4-0.4-0.3-0.5-0.4-0.3-0.3-0.3-0.5
Time in open arm before self-admin0.60.71.8-1.3-0.70.8-0.8-0.8-0.7-0.8-0.7-0.8-0.8-0.8-0.8-0.7-0.6
Time in open arm after self-admin0.30.33.2-1.8-0.30.5-0.0-0.1-0.3-0.2-0.4-0.2-0.2-0.3-0.3-0.4-0.1
Bone: periosteal estimation0.51.11.3-1.1-1.11.0-1.0-1.0-1.1-1.0-1.0-1.0-1.0-1.0-1.1-1.0-1.1
Bone: periosteal perimeter0.61.11.3-1.1-1.11.0-1.0-1.0-1.1-1.0-1.1-1.0-1.0-1.0-1.1-1.0-1.1
Bone: post-yield work0.10.20.4-0.6-0.40.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.3-0.4-0.2
Progressive ratio test 1 active lever presses2.53.08.6-2.9-1.71.7-1.6-1.6-1.7-1.6-1.6-1.6-1.7-1.6-1.6-1.6-1.2
Progressive ratio test 1 breakpoint2.63.28.8-3.0-1.71.8-1.6-1.7-1.7-1.7-1.7-1.6-1.7-1.7-1.7-1.7-1.2
Progressive ratio test 1 inactive lever presses1.72.46.2-2.5-1.61.7-1.3-1.3-1.6-1.4-1.5-1.4-1.4-1.5-1.5-1.5-1.1
Progressive ratio test 2 active lever presses1.61.94.5-2.1-1.51.4-1.2-1.3-1.5-1.3-1.4-1.2-1.3-1.3-1.3-1.4-0.9
Progressive ratio test 2 breakpoint1.51.74.0-2.0-1.41.3-1.2-1.2-1.4-1.2-1.3-1.2-1.2-1.2-1.2-1.3-0.8
Progressive ratio test 2 inactive lever presses3.86.27.1-2.7-2.52.6-2.4-2.5-2.5-2.5-2.5-2.4-2.5-2.5-2.5-2.5-2.0
Incentive Sensitization - Responses1.52.12.7-1.7-1.61.5-1.4-1.4-1.6-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.2
Incentive Sensitization - Breakpoint1.31.72.2-1.4-1.51.3-1.3-1.3-1.4-1.3-1.2-1.3-1.3-1.3-1.3-1.2-1.2
Sum of active levers in priming session hrs 5-67.06.58.7-2.9-2.62.7-2.5-2.5-2.6-2.5-2.5-2.5-2.5-2.5-2.5-2.5-2.3
Progressive ratio0.30.40.60.6-0.70.5-0.6-0.6-0.7-0.6-0.8-0.6-0.6-0.6-0.6-0.8-0.5
Food seeking constrained by brief footshock1.11.31.70.51.2-1.31.11.11.21.21.21.11.11.21.21.21.2
Seeking ratio, punishment vs. effort0.50.71.1-0.31.0-0.80.70.81.00.81.00.70.80.80.81.00.7
Retroperitoneal fat weight1.45.810.0-1.2-2.12.2-2.7-2.5-2.1-2.5-2.3-2.6-2.5-2.5-2.5-2.2-3.2
Reaction time number correct1.01.92.7-0.41.2-1.31.71.61.21.51.21.51.51.41.41.31.6
Reaction time mean minus median0.30.72.91.70.9-1.00.50.50.90.60.70.60.60.70.80.80.5
Reaction time mean minus median AUC0.20.61.71.30.9-1.00.60.60.90.70.60.60.70.70.80.70.6
Reaction time num false alarms3.75.36.01.12.4-2.32.42.42.42.42.32.42.42.42.32.32.5
Reaction time num false alarms AUC2.33.64.11.02.0-1.92.01.92.01.91.92.02.02.02.01.92.0
Reaction time trials correct on left1.01.92.7-0.41.2-1.31.71.61.21.51.21.51.51.41.41.31.6
Reaction time trials on left1.01.92.7-0.41.2-1.41.71.61.31.51.21.61.51.41.41.31.6
Reaction time mean0.10.10.60.80.4-0.4-0.2-0.10.3-0.00.2-0.1-0.00.10.10.2-0.1
Reaction time mean AUC0.10.20.91.00.6-0.60.00.10.60.30.40.20.20.30.40.50.2
Median of all reaction times0.00.00.20.30.2-0.1-0.4-0.30.1-0.20.1-0.3-0.2-0.1-0.10.1-0.2
Reaction time omissions0.40.61.00.60.9-1.00.60.70.90.80.90.70.70.80.90.90.8
Reaction time false alarm rate0.40.50.80.70.9-0.70.60.60.90.70.80.70.70.70.70.80.6
Reaction time premature initiation rate0.81.11.7-1.3-1.21.2-1.0-1.0-1.2-1.0-0.9-1.0-1.1-1.0-1.0-0.9-0.8
Reaction time premature initiations0.10.11.3-1.1-0.30.30.0-0.1-0.3-0.1-0.2-0.0-0.1-0.1-0.1-0.10.2
Std. dev. reaction times0.10.11.31.20.2-0.2-0.4-0.30.2-0.2-0.1-0.2-0.2-0.1-0.00.0-0.2
Reaction time trials completed1.01.92.7-0.41.2-1.41.71.61.31.51.21.61.51.41.41.31.6
Reaction time trials AUC1.22.33.2-0.31.4-1.51.81.71.41.61.41.71.61.61.51.41.7
Run reversals in cocaine runway, females0.20.21.0-1.0-0.40.5-0.2-0.3-0.4-0.4-0.6-0.3-0.4-0.4-0.4-0.60.1
Run reversals in cocaine runway, males0.10.10.40.3-0.10.0-0.3-0.2-0.0-0.2-0.1-0.2-0.2-0.2-0.1-0.1-0.7
Latency to leave start box in cocaine runway2.22.52.91.41.4-1.61.61.61.41.61.71.61.61.61.61.71.4
Latency to leave start box in cocaine runway, F0.81.01.91.40.8-1.00.90.90.80.91.10.90.91.01.01.10.8
Latency to leave start box in cocaine runway, M1.31.21.50.61.1-1.11.21.21.11.21.11.21.21.11.11.11.1
Std. dev. time between licks in bursts0.20.31.3-1.1-0.60.5-0.2-0.2-0.6-0.4-0.7-0.3-0.3-0.4-0.4-0.6-0.1
Total sessions with >9 infusions2.42.93.9-2.0-1.71.7-1.8-1.7-1.6-1.7-1.6-1.7-1.7-1.7-1.7-1.6-1.6
Short access day 1 total inactive lever presses2.02.74.9-0.6-1.51.6-2.0-1.8-1.5-1.7-1.3-1.9-1.7-1.7-1.7-1.3-2.2
Short access day 10 total inactive lever presses0.00.00.10.4-0.10.20.10.2-0.20.10.00.00.1-0.0-0.10.0-0.3
Short access day 1 total infusions0.91.11.3-1.0-1.11.1-1.1-1.1-1.0-1.1-1.0-1.1-1.1-1.1-1.1-1.0-1.2
Short access day 10 total infusions0.91.22.5-1.6-1.01.0-1.1-1.1-1.0-1.1-0.9-1.1-1.1-1.0-1.0-0.9-0.9
Short access total infusions1.92.42.9-1.7-1.51.5-1.7-1.6-1.4-1.6-1.5-1.6-1.6-1.5-1.5-1.5-1.4
Short access day 1 locomotion0.20.20.80.1-0.40.4-0.5-0.4-0.3-0.4-0.4-0.5-0.5-0.5-0.5-0.4-0.9
Short access day 10 total locomotion0.20.30.60.80.5-0.50.50.50.60.50.60.50.50.50.50.60.5
Short access total locomotion0.50.60.8-0.6-0.70.8-0.9-0.8-0.6-0.8-0.7-0.8-0.8-0.8-0.8-0.7-0.8
One hour access (0.3 mA shock)1.31.54.1-2.0-1.31.2-1.0-1.1-1.2-1.2-1.3-1.1-1.1-1.1-1.1-1.3-0.5
Compulsive drug intake0.40.50.7-0.10.6-0.60.80.80.60.70.70.80.70.70.60.70.7
One hour access (shock baseline)0.50.81.0-0.7-0.90.8-1.0-1.0-0.8-1.0-0.9-1.0-0.9-0.9-0.9-0.9-0.7
Social response proportion0.80.91.60.51.0-1.20.80.91.01.01.30.90.91.01.01.20.6
Social responses2.43.13.71.21.7-1.81.91.91.71.91.91.81.91.81.71.81.4
Social time0.20.30.50.00.4-0.50.70.60.40.60.70.60.60.60.60.60.7
Soleus weight1.54.57.42.72.2-2.21.91.92.22.02.02.02.02.12.12.12.0
Bone: stiffness1.11.92.3-1.1-1.41.3-1.5-1.4-1.4-1.4-1.3-1.4-1.4-1.4-1.4-1.3-1.5
Tibialis anterior weight0.10.30.5-0.7-0.60.6-0.4-0.4-0.6-0.5-0.6-0.5-0.5-0.5-0.6-0.5-0.5
Time to tail flick, vehicle, before self-admin0.20.21.61.30.4-0.40.20.30.40.30.40.30.30.30.30.40.1
Time to tail flick, vehicle, after self-admin1.21.61.9-1.2-1.21.2-1.4-1.3-1.2-1.3-1.2-1.3-1.3-1.3-1.3-1.3-1.3
Time to tail flick, test, before self-admin1.91.92.5-0.0-1.31.3-1.6-1.6-1.3-1.5-1.4-1.5-1.5-1.4-1.4-1.4-1.6
Time to tail flick, test, after self-admin2.12.22.8-0.6-1.51.5-1.7-1.6-1.5-1.6-1.4-1.6-1.6-1.5-1.5-1.3-1.6
Delta time to tail flick, vehicle, before/after SA2.01.93.6-1.9-1.31.3-1.4-1.4-1.3-1.4-1.3-1.4-1.4-1.4-1.3-1.3-1.2
Delta time to tail flick, test, before/after SA0.00.00.1-0.3-0.20.0-0.2-0.1-0.2-0.10.2-0.2-0.2-0.1-0.10.2-0.3
Tibia length0.72.03.1-1.8-1.41.3-1.3-1.3-1.4-1.3-1.5-1.4-1.4-1.4-1.4-1.4-1.5
Ambulatory time before self-admin0.50.71.5-0.8-0.70.9-0.7-0.9-0.7-0.9-1.2-0.7-0.8-0.8-0.8-1.2-0.4
Ambulatory time after self-admin0.40.50.9-0.4-0.70.8-0.6-0.7-0.7-0.8-0.9-0.6-0.7-0.7-0.7-1.0-0.2
Bone: tissue strength2.02.02.4-0.7-1.41.4-1.5-1.5-1.4-1.5-1.5-1.5-1.5-1.4-1.4-1.5-1.3
Total heroin consumption4.35.16.2-2.1-2.12.3-2.2-2.3-2.1-2.3-2.5-2.2-2.3-2.3-2.3-2.5-2.1
Bone: trabecular number0.00.10.2-0.20.2-0.30.30.20.20.20.30.30.20.30.30.20.4
Bone: trabecular spacing2.63.53.9-1.1-1.91.9-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.9-2.0
Bone: trabecular thickness0.40.50.70.30.6-0.60.80.70.60.70.60.80.70.70.70.70.8
Bone: trabecular tissue density0.30.41.41.20.6-0.60.50.60.60.60.60.50.60.50.50.60.2
Water consumed over 24 hours0.10.20.3-0.4-0.50.4-0.4-0.4-0.6-0.4-0.5-0.4-0.4-0.4-0.4-0.4-0.3
Number of responses in last shaping day0.30.41.41.20.6-0.40.60.60.60.50.50.60.60.50.50.50.5