Hub : Genes

Pls1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Pls1 0.23 0.12 4.2e-05 0.12 0.18 0.14 0.15 4.8e-04 1.4e-05 1.2e-04 8.8e-05
2 Brain mRNA stability Pls1 0.08 0.05 9.6e-06 0.06 0.05 0.04 0.06 1.2e-06 8.2e-06 1.4e-04 3.6e-06
3 Liver gene expression Pls1 0.32 0.1 0.0e+00 0.37 0.37 0.38 0.36 1.2e-43 5.2e-43 4.7e-44 7.4e-42
4 pVTA gene expression Pls1 0.3 0.11 0.0e+00 0.34 0.27 0.33 0.33 6.3e-28 3.5e-22 7.3e-27 3.2e-27
5 BLA gene expression Pls1 0.06 0.04 2.5e-03 0.06 0.04 0.05 0.05 4.6e-04 2.0e-03 1.2e-03 1.0e-03
6 LHb gene expression Pls1 0.17 0.11 7.6e-03 0.07 0.04 0.02 0.01 1.1e-02 4.5e-02 1.4e-01 1.5e-01
7 NAcc mRNA stability Pls1 0.02 0.02 9.0e-04 0.02 0.02 0.03 0.02 1.1e-04 2.9e-04 9.6e-05 1.6e-04
8 Brain gene expression Pls1 0.28 0.1 0.0e+00 0.34 0.34 0.34 0.35 1.1e-32 3.2e-33 2.0e-32 1.1e-33
9 NAcc gene expression Pls1 0.29 0.11 0.0e+00 0.27 0.26 0.29 0.29 1.7e-40 1.1e-39 5.2e-44 4.3e-44
10 Adipose gene expression Pls1 0.04 0.03 3.3e-04 0.03 0.03 0.03 0.02 5.3e-04 3.5e-04 7.1e-04 1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.91.52.61.51.21.41.11.61.21.51.01.0-0.1
Area under the delay curve0.30.30.70.80.60.60.50.10.60.60.30.1-0.7
BMI with tail6.321.736.3-5.8-6.0-5.4-4.8-5.0-4.3-4.6-4.1-3.70.1
BMI without tail3.310.122.3-4.7-4.3-3.6-3.0-2.9-3.1-2.7-2.5-2.01.5
Body weight2.812.324.3-3.8-4.9-4.0-3.4-3.5-3.4-4.0-3.2-2.5-0.3
Weight adjusted by age0.60.82.9-0.7-1.6-0.9-0.7-0.3-0.8-1.7-0.7-0.20.1
Bone surface1.32.44.42.11.91.81.51.51.31.91.01.1-0.6
Bone volume1.01.82.71.61.51.61.31.51.21.61.01.1-0.2
Breakpoint value in progressive ratio session0.10.10.40.60.40.2-0.10.50.5-0.30.3-0.1-0.3
Number of licking bursts0.10.20.50.70.70.50.50.30.30.40.30.4-0.1
Context. condit. distance diff. score0.70.82.8-0.0-0.1-0.8-0.9-0.4-0.7-1.0-1.0-1.2-1.7
Locomotion velocity, session 12.02.24.9-2.2-1.6-1.7-1.6-1.6-1.4-1.2-1.1-1.20.5
Locomotion distance, session 14.96.110.9-3.3-2.6-2.7-2.8-2.6-2.7-2.2-2.3-2.20.1
Locomotion velocity, session 25.46.310.5-3.2-2.6-2.8-2.7-2.7-2.7-1.9-2.4-2.4-0.4
Locomotion distance, session 26.28.716.6-4.1-3.3-3.3-3.1-3.2-3.3-2.3-2.8-2.50.1
Locomotion velocity, session 31.11.22.3-1.4-0.5-1.2-1.3-0.9-1.2-0.4-1.1-1.5-0.6
Locomotion distance, session 30.20.20.7-0.0-0.0-0.3-0.50.0-0.5-0.0-0.6-0.7-0.9
Stereotopy head waving bouts, day 30.10.10.30.30.30.10.3-0.30.1-0.2-0.1-0.0-0.6
Stereotopy head waving duration, day 30.20.20.7-0.8-0.5-0.5-0.3-0.8-0.4-0.5-0.3-0.20.3
Locomotion velocity, session 73.53.98.3-2.9-2.3-2.2-2.1-1.7-2.1-1.4-1.8-1.70.3
Locomotion distance, session 70.30.40.9-0.9-0.9-0.7-0.6-0.2-0.7-0.7-0.3-0.10.6
Stereotopy head waving bouts, day 70.60.72.51.01.40.70.30.10.50.80.0-0.5-1.6
Stereotopy head waving duration, day 70.70.92.50.91.61.10.70.60.81.50.50.1-0.7
Locomotion velocity, session 82.93.56.6-2.6-1.5-2.2-2.0-2.0-2.1-1.4-1.8-1.9-0.3
Locomotion distance, session 82.73.95.1-2.2-1.7-2.2-2.3-1.9-2.2-1.7-2.1-2.1-0.9
Degree of sensitization distance0.40.41.5-0.7-0.8-0.4-0.1-0.1-0.0-0.70.20.41.2
Degree of sensitization stereotypy0.60.63.50.30.7-0.1-0.5-0.4-0.30.2-0.7-1.1-1.9
Conditioned locomotion0.60.72.4-0.00.50.40.90.50.70.70.91.01.5
Cocaine response after cond. corrected0.10.20.8-0.8-0.1-0.3-0.3-0.3-0.3-0.00.0-0.00.9
Cocaine response after cond. not corrected0.20.31.3-0.8-0.2-0.2-0.3-0.4-0.40.00.10.11.1
Cocaine response before conditioning0.10.10.5-0.2-0.10.1-0.00.0-0.10.30.10.20.7
Saline control response1.82.43.4-1.7-1.6-1.9-1.7-1.4-1.5-1.9-1.4-1.4-0.4
Bone: connectivity density1.11.83.81.41.51.51.31.41.31.91.11.10.1
Bone: cortical apparent density0.00.00.2-0.1-0.1-0.2-0.2-0.2-0.3-0.2-0.0-0.10.5
Bone: cortical area2.64.15.3-1.8-1.8-2.0-2.3-2.1-2.3-1.6-2.3-2.2-1.7
Bone: cortical porosity0.90.91.4-0.8-1.0-1.0-1.1-0.5-0.9-0.7-1.1-1.2-1.2
Bone: cortical porosity1.31.42.2-1.0-1.1-1.2-1.3-0.8-1.2-0.8-1.4-1.5-1.4
Bone: cortical thickness1.42.32.8-1.4-1.5-1.5-1.7-1.6-1.7-1.3-1.6-1.6-1.0
Bone: cortical thickness0.00.00.20.1-0.40.00.10.30.0-0.2-0.10.1-0.3
Bone: cortical tissue density0.00.00.2-0.1-0.0-0.2-0.2-0.2-0.3-0.2-0.0-0.10.5
Condit. Reinf. active minus inactive responses0.10.20.50.2-0.4-0.3-0.3-0.1-0.0-0.7-0.2-0.3-0.7
Condit. Reinf. active-inactive response ratio2.52.74.0-1.4-2.0-1.8-1.8-1.6-1.4-2.0-1.6-1.6-1.0
Condit. Reinf. active responses0.00.00.20.20.10.10.10.40.30.00.30.1-0.0
Condit. Reinf. inactive responses2.02.43.41.21.71.61.71.81.51.61.61.51.1
Incentive salience index mean0.70.91.4-0.5-1.0-1.0-1.0-0.8-0.7-1.1-1.0-1.0-1.2
Condit. Reinf. lever presses2.23.03.7-1.9-1.9-1.9-1.8-1.9-1.7-1.6-1.8-1.7-0.9
Condit. Reinf. active minus inactive responses0.30.31.40.60.30.60.51.20.60.30.50.50.1
Condit. Reinf. active-inactive response ratio0.20.20.8-0.5-0.5-0.2-0.20.4-0.1-0.30.20.20.9
Condit. Reinf. active responses0.60.82.01.11.01.00.81.40.80.90.70.7-0.2
Condit. Reinf. inactive responses0.60.71.31.11.11.00.80.90.71.10.50.5-0.5
Condit. Reinf. lever presses0.20.31.01.00.50.30.20.80.20.0-0.00.0-1.0
Condit. Reinf. lever reinforcers received0.40.61.61.10.80.80.61.30.70.50.50.5-0.5
Conditioned reinforcement - actives0.10.20.70.40.90.40.20.30.50.80.40.40.0
Conditioned reinforcement - inactives0.10.20.5-0.7-0.1-0.4-0.7-0.6-0.40.3-0.3-0.5-0.0
Conditioned locomotion0.10.10.60.20.80.10.0-0.00.1-0.10.20.0-0.1
Patch foraging indifference point 0 sec0.00.10.3-0.2-0.2-0.2-0.0-0.6-0.40.1-0.10.20.5
Patch foraging indifference point AUC0.10.20.6-0.6-0.4-0.00.10.20.10.60.20.30.8
Delay disc. indifference point, 0s delay1.01.11.91.41.41.21.01.11.20.70.90.6-0.4
Delay disc. indifference point, 16s delay0.20.20.6-0.1-0.4-0.3-0.3-0.5-0.30.0-0.5-0.5-0.8
Delay disc. indifference point, 2s delay0.30.30.7-0.4-0.4-0.5-0.5-0.8-0.7-0.6-0.7-0.5-0.6
Delay disc. indifference point, 24s delay0.10.10.30.50.20.30.2-0.00.40.30.30.0-0.3
Delay disc. indifference point, 4s delay1.21.22.50.81.51.31.20.61.11.61.10.90.6
Delay disc. indifference point, 8s delay0.30.41.41.20.50.60.50.30.60.10.20.1-1.0
Indifference point function ln k0.00.00.20.4-0.10.0-0.1-0.1-0.1-0.1-0.1-0.1-0.4
Indifference point function log k0.00.00.20.4-0.10.0-0.1-0.1-0.1-0.1-0.1-0.1-0.4
Patch foraging total patch changes 0 sec0.10.20.6-0.4-0.5-0.4-0.3-0.8-0.6-0.2-0.4-0.10.2
Patch foraging total patch changes 12 sec0.10.20.5-0.7-0.7-0.6-0.4-0.3-0.2-0.2-0.3-0.40.1
Patch foraging total patch changes 18 sec0.10.20.6-0.0-0.30.20.40.30.40.20.40.60.8
Patch foraging total patch changes 24 sec0.20.41.00.50.20.60.51.00.90.70.60.70.4
Patch foraging total patch changes 6 sec0.20.30.9-0.10.20.40.60.00.40.70.50.70.9
Patch foraging time to switch 0 sec0.91.83.51.51.91.41.51.11.50.91.41.00.4
Patch foraging water rate 0 sec0.40.92.2-1.3-1.5-1.0-1.1-0.9-1.0-0.6-0.9-0.50.3
Patch foraging water rate 12 sec0.40.81.5-1.0-1.2-0.9-0.9-1.0-1.1-0.5-1.1-0.6-0.5
Patch foraging water rate 18 sec2.33.64.7-2.1-2.2-2.1-1.9-2.1-2.2-1.9-1.9-1.4-0.3
Patch foraging water rate 24 sec0.10.20.6-0.4-0.8-0.5-0.2-0.1-0.4-0.5-0.40.10.0
Patch foraging water rate 6 sec0.81.11.8-1.0-1.1-1.1-1.1-1.0-1.4-0.9-1.3-0.9-0.6
Seeking ratio, delayed vs. immediate footshock0.10.10.80.10.20.10.00.1-0.10.9-0.2-0.3-0.5
Distance traveled before self-admin0.91.21.7-1.3-1.0-1.3-1.3-1.1-1.1-1.3-1.0-1.0-0.1
Distance traveled after self-admin0.10.10.40.40.10.20.10.30.2-0.60.20.20.1
Extensor digitorum longus weight2.810.813.2-3.6-3.3-3.6-3.5-3.6-3.6-3.3-3.4-3.1-1.1
Bone: elastic displacement1.71.93.5-1.3-1.9-1.6-1.4-1.1-1.3-1.8-1.4-1.2-0.6
Bone: elastic work1.01.32.2-1.1-1.5-1.4-1.2-0.7-1.0-1.4-1.2-1.0-0.6
Bone: endosteal estimation0.30.71.1-1.1-0.7-1.0-0.9-0.8-0.9-0.6-0.9-0.9-0.5
Bone: endosteal perimeter1.73.74.7-1.7-1.5-2.1-2.2-2.1-2.1-1.7-2.1-2.1-1.5
Epididymis fat weight0.51.84.6-2.1-2.1-1.4-1.3-1.0-1.2-0.9-0.9-0.70.9
Delta time in closed arm before/after self-admin0.30.31.90.20.3-0.3-0.2-0.2-0.1-0.4-0.5-0.8-1.4
Delta time in open arm before/after self-admin0.60.61.40.00.80.70.70.60.61.10.80.81.2
Diff in mean of infusions in LGA sessions0.30.31.50.80.70.30.10.20.50.2-0.1-0.3-1.2
Delay discount exponential model param0.20.20.5-0.7-0.5-0.6-0.50.0-0.5-0.5-0.3-0.20.5
Extinction: sum of active levers before priming0.40.42.7-0.1-0.9-0.6-0.3-0.0-0.1-1.6-0.4-0.3-0.3
Active lever presses in extinction session 60.10.10.3-0.0-0.3-0.3-0.20.10.1-0.6-0.2-0.20.1
Bone: final force0.10.10.3-0.2-0.3-0.2-0.30.1-0.20.2-0.4-0.3-0.6
Bone: final moment0.10.10.3-0.4-0.5-0.3-0.40.1-0.2-0.1-0.4-0.4-0.5
Food consumed during 24 hour testing period0.60.81.61.31.31.10.90.90.90.60.80.80.0
Glucose0.50.81.9-1.4-1.1-1.0-0.8-0.7-0.7-0.9-0.6-0.60.5
Heart weight0.71.11.9-0.5-1.2-1.2-1.1-0.9-1.4-1.4-1.2-0.6-0.7
Delay discount hyperbolic model param0.20.20.4-0.7-0.6-0.6-0.6-0.0-0.5-0.6-0.3-0.30.3
Intermittent access intake day 1-15 change0.10.10.50.40.30.40.30.40.30.70.30.4-0.1
Intermittent access intake escalation0.10.20.70.40.30.50.50.50.40.80.40.60.1
Intermittent access intake escalation 21.01.12.31.51.31.21.10.81.01.10.70.9-0.5
Intermitt. access day 1 inactive lever presses0.20.71.1-1.0-0.7-0.8-0.8-0.9-1.1-0.9-0.7-0.70.2
Intermitt. access day 15 inactive lever presses0.20.31.70.60.60.2-0.0-0.7-0.2-0.0-0.4-0.4-1.3
Intermitt. access escalation Index0.71.11.90.40.91.11.00.80.81.31.11.21.4
Intermittent access day 1 total infusions0.30.51.6-0.60.0-0.7-1.0-0.5-0.5-1.3-0.4-0.8-0.3
Intermittent access day 15 total infusions0.10.10.4-0.60.1-0.4-0.6-0.2-0.4-0.3-0.2-0.20.0
Intermittent access terminal intake (last 3 days)0.20.30.6-0.30.2-0.5-0.8-0.6-0.6-0.7-0.5-0.5-0.6
Intermittent access total infusions0.60.71.6-0.7-0.0-1.0-1.1-0.8-0.9-1.3-0.8-0.9-0.6
Intermittent access day 1 locomotion0.91.12.2-1.2-0.6-1.2-1.3-1.2-1.0-1.5-0.8-1.10.1
Intermittent access day 15 total locomotion0.61.11.9-1.0-0.6-1.2-1.3-1.2-1.2-0.7-1.0-1.4-0.8
Intermittent access total locomotion1.01.21.8-1.0-0.5-1.2-1.3-1.3-1.2-1.3-0.9-1.2-0.4
Intermittent access standard deviation0.40.92.8-0.1-0.0-0.7-0.7-1.1-0.8-0.8-1.1-1.1-1.7
Left kidney weight2.310.516.2-3.5-4.0-3.6-3.1-3.8-3.4-3.8-3.0-2.20.0
Right kidney weight2.611.916.7-3.9-3.9-3.8-3.4-4.1-3.6-3.9-3.2-2.6-0.0
Cocaine induced anxiety0.30.41.21.10.80.70.30.40.50.20.50.5-0.5
Post-drug Anxiety0.10.20.40.70.60.40.1-0.0-0.00.20.10.2-0.7
Baseline Anxiety0.60.71.1-0.9-0.6-0.9-0.7-0.7-1.0-0.4-1.0-0.9-0.5
Tail length0.20.92.40.70.20.91.11.20.50.10.81.61.3
Length with tail0.00.20.90.4-0.6-0.2-0.0-0.1-0.4-0.9-0.40.2-0.6
Length without tail0.51.53.20.1-1.3-1.0-1.0-1.4-1.0-1.6-1.3-1.0-1.8
Times rat made contact with spout1.21.43.7-0.1-0.4-1.0-1.1-1.0-1.0-1.4-1.3-1.4-1.9
Lifetime Intake0.40.51.3-0.60.0-0.8-1.0-0.6-0.6-1.2-0.6-0.8-0.5
Liver weight, left1.11.93.4-1.5-1.3-1.4-1.2-1.8-1.5-1.4-1.3-1.3-0.1
Liver weight, right1.11.93.9-1.8-1.3-1.5-1.4-2.0-1.4-1.3-1.1-1.00.4
Locomotor activity0.30.52.6-0.8-0.9-0.4-0.0-0.1-0.4-0.60.00.71.6
Locomotor testing distance0.10.21.5-0.4-0.3-0.10.20.4-0.1-0.10.20.61.2
Locomotor testing rearing0.40.92.2-1.5-0.9-1.2-0.8-0.5-1.0-1.1-0.7-0.30.8
Locomotion in novel chamber1.62.13.31.61.81.51.51.51.21.41.41.40.5
Locomotion in novel chamber post-restriction0.61.01.50.91.01.21.10.80.90.91.01.20.9
Fecal boli incidents, locomotor time 10.40.61.6-1.3-0.9-0.8-0.7-1.0-0.7-0.1-0.6-0.60.3
Change in fecal boli incidents, locomotor task0.20.20.8-0.7-0.8-0.4-0.2-0.1-0.1-0.20.00.20.9
Time >=10cm from walls, locomotor time 10.50.50.9-0.7-0.6-1.0-0.9-0.5-0.7-0.6-0.8-0.9-0.5
Bouts of movement, locomotor time 10.10.10.70.10.0-0.2-0.0-0.0-0.1-0.8-0.0-0.1-0.2
Total resting periods, locomotor time 10.20.20.9-0.2-0.2-0.4-0.3-0.3-0.4-1.0-0.3-0.4-0.3
Rest time, locomotor task time 13.03.75.1-1.4-1.6-2.0-2.1-1.8-1.9-2.0-2.0-2.3-2.0
Distance moved, locomotor task time 10.91.43.30.30.91.01.21.10.91.21.21.41.8
Vertical activity count, locomotor time 10.41.01.71.21.31.11.21.00.80.80.91.00.3
Time >=10cm from walls, locomotor time 20.30.52.40.20.4-0.3-0.6-0.0-0.6-0.2-0.8-0.9-1.6
Bouts of movement, locomotor time 20.60.91.3-0.9-1.0-1.1-0.9-1.0-0.9-1.1-0.8-0.9-0.5
Total resting periods, locomotor time 20.61.11.8-0.8-1.1-1.2-1.0-1.2-1.0-1.3-1.0-1.0-0.7
Rest time, locomotor task time 20.20.30.7-0.2-0.3-0.5-0.6-0.8-0.5-0.5-0.5-0.6-0.5
Distance moved, locomotor task time 20.50.61.50.51.10.70.81.20.61.10.60.50.1
Vertical activity count, locomotor time 20.30.51.01.01.00.60.60.90.60.10.40.3-0.8
Light reinforcement 10.00.00.20.00.1-0.00.1-0.3-0.50.1-0.2-0.0-0.3
Light reinforcement 20.20.41.50.1-0.2-0.4-0.5-0.6-0.6-0.2-0.8-0.6-1.2
Bone: marrow area0.40.91.3-1.1-0.8-1.1-1.0-0.9-1.0-0.7-1.0-0.9-0.5
Bone: maximum diameter4.17.610.1-3.0-2.5-2.9-3.1-3.1-3.2-2.1-3.0-2.9-1.4
Bone: maximum force0.20.41.0-0.3-0.3-0.6-0.8-0.5-0.8-0.3-0.9-0.8-1.0
Bone: maximum moment0.30.60.9-0.5-0.6-0.8-0.9-0.5-0.9-0.5-1.0-0.8-0.9
Mean time between licks in bursts0.30.72.20.0-0.6-0.7-0.7-0.8-0.6-0.9-0.9-0.9-1.5
Mean num. licks in bursts1.21.82.8-1.0-1.3-1.4-1.4-1.2-1.2-1.7-1.4-1.5-1.3
Cd content in liver0.50.61.41.21.20.70.31.00.60.40.4-0.0-0.9
Co content in liver0.60.61.2-0.4-0.4-0.9-1.0-0.3-0.6-1.0-0.8-1.1-1.0
Cu content in liver0.70.82.01.41.30.90.70.80.61.00.40.3-1.0
Fe content in liver0.20.20.60.80.60.40.20.60.20.3-0.0-0.0-0.8
K content in liver0.80.83.3-1.8-0.8-0.8-0.7-0.6-0.60.4-0.2-0.41.4
Mg content in liver0.20.20.8-0.9-0.3-0.3-0.3-0.1-0.20.6-0.1-0.30.5
Mn content in liver3.13.45.8-2.4-1.8-2.1-2.1-1.5-1.9-1.2-1.9-2.1-0.7
Na content in liver0.40.42.3-0.80.10.20.0-0.00.01.50.30.11.0
Rb content in liver0.10.10.3-0.5-0.4-0.3-0.50.1-0.20.1-0.3-0.5-0.2
Se content in liver1.31.53.21.11.21.41.21.31.31.81.11.10.5
Sr content in liver0.20.11.0-0.10.50.30.1-0.3-0.01.0-0.0-0.1-0.2
Zn content in liver1.11.21.70.51.11.01.01.31.01.21.21.01.3
Bone: minimum diameter0.30.62.5-0.0-0.3-0.5-0.7-0.2-0.7-0.4-0.9-0.9-1.6
Time in familiar zone, hab. session 16.46.27.92.42.12.72.82.52.82.62.62.61.4
Time in novel zone, hab. session 14.84.86.9-1.9-2.1-2.5-2.4-2.0-2.5-2.6-2.3-2.1-1.2
Total zone transitions, hab. session 13.65.111.4-3.4-2.6-2.5-2.3-2.2-2.4-1.4-2.1-1.90.3
Total locomotion distance, hab. session 12.02.87.5-2.7-2.3-1.9-1.5-1.6-1.5-1.0-1.1-1.01.1
Locomotion velocity, hab. session 12.53.610.1-3.2-2.5-2.1-1.8-1.8-1.7-0.9-1.3-1.31.0
Time in familiar zone, hab. session 20.70.71.10.90.71.00.81.01.00.70.90.80.3
Time in novel zone, hab. session 22.52.53.4-1.5-1.5-1.8-1.7-1.8-1.8-1.7-1.7-1.5-0.8
Total zone transitions, hab. session 23.95.010.3-3.2-2.5-2.5-2.4-2.3-2.4-1.6-2.1-2.00.2
Total locomotion distance, hab. session 21.62.26.4-2.5-1.9-1.5-1.3-1.4-1.2-1.0-0.9-0.71.3
Locomotion velocity, hab. session 21.72.26.9-2.6-1.9-1.6-1.3-1.5-1.3-0.9-0.9-0.71.3
Novel to familiar place preference ratio0.10.10.2-0.0-0.4-0.20.1-0.1-0.1-0.5-0.10.20.0
Novelty place preference0.20.20.6-0.1-0.7-0.4-0.1-0.2-0.3-0.8-0.3-0.0-0.1
Time in novel zone, NPP test0.40.51.6-0.3-1.0-0.7-0.5-0.5-0.6-1.3-0.6-0.3-0.3
Total zone transitions, NPP test8.412.119.8-4.4-3.9-3.8-3.7-3.7-3.8-3.3-3.2-2.90.0
Total locomotion distance, NPP test4.86.515.0-3.9-3.2-2.8-2.5-2.7-2.5-2.2-2.0-1.71.1
Locomotion velocity, NPP test3.44.812.4-3.5-2.7-2.4-2.0-2.3-2.1-1.6-1.6-1.41.2
Intraocular pressure0.60.91.6-1.3-1.1-1.0-1.0-0.7-0.9-1.0-0.9-0.80.0
Delta distance traveled before/after self-admin1.51.62.41.50.91.51.51.51.30.71.21.40.6
Delta ambulatory time before/after self-admin1.31.62.71.20.71.41.51.21.20.71.41.61.3
Parametrial fat weight0.10.30.8-0.9-0.7-0.6-0.6-0.3-0.4-0.0-0.3-0.30.3
Pavlov. Cond. lever latency1.31.62.11.01.41.31.31.21.41.21.41.21.0
Pavlov. Cond. magazine entry latency3.14.05.5-1.3-1.9-2.1-2.3-1.6-2.0-2.0-2.2-2.3-2.1
Pavlov. Cond. change in total contacts1.11.12.1-0.5-0.7-0.9-1.2-1.0-1.2-0.9-1.3-1.3-1.4
Pavlov. Cond. index score2.32.83.7-1.1-1.7-1.7-1.9-1.4-1.8-1.7-1.9-1.8-1.7
Pavlov. Cond. latency score2.22.83.5-1.2-1.8-1.8-1.9-1.4-1.7-1.7-1.9-1.7-1.5
Pavlov. Cond. lever contacts1.82.12.8-1.2-1.6-1.6-1.6-1.2-1.6-1.5-1.7-1.5-1.2
Pavlov. Cond. magazine entry number1.62.03.50.51.11.41.71.01.41.61.61.71.9
Pavlov. Cond. intertrial magazine entries3.54.26.32.52.42.22.22.32.21.82.01.80.3
Pavlov. Cond. lever-magazine prob. diff.2.12.73.5-1.0-1.4-1.6-1.9-1.4-1.7-1.6-1.8-1.8-1.8
Pavlov. Cond. response bias1.62.03.6-0.6-1.0-1.3-1.6-1.1-1.5-1.4-1.6-1.7-1.9
Pavlov. Cond. lever latency0.10.20.50.20.70.40.4-0.00.40.50.50.40.5
Pavlov. Cond. magazine entry latency1.82.23.8-0.8-1.5-1.5-1.6-1.4-1.4-1.9-1.5-1.5-1.5
Pavlov. Cond. change in total contacts1.01.63.1-1.3-1.8-1.5-1.3-0.7-1.2-1.6-1.2-1.1-0.3
Pavlov. Cond. index score0.50.71.6-0.2-1.0-0.8-0.8-0.5-0.7-1.3-0.9-0.8-1.1
Pavlov. Cond. latency score0.60.81.8-0.3-1.0-0.9-0.9-0.6-0.8-1.3-0.9-0.9-1.0
Pavlov. Cond. lever contacts0.40.61.0-0.2-1.0-0.8-0.8-0.3-0.7-1.0-0.8-0.7-0.9
Pavlov. Cond. magazine entry number1.11.32.20.51.01.11.21.01.01.41.21.31.5
Pavlov. Cond. intertrial magazine entries4.67.08.62.62.72.92.92.92.62.92.62.51.2
Pavlov. Cond. lever-magazine prob. diff.0.60.81.7-0.3-1.0-0.9-0.9-0.5-0.8-1.3-0.9-0.9-1.1
Pavlov. Cond. response bias0.81.11.6-0.5-1.1-1.1-1.1-0.6-1.0-1.2-1.2-1.1-1.2
Time in closed arm before self-admin0.40.53.4-0.6-0.30.10.1-0.00.20.30.70.91.8
Time in closed arm after self-admin0.30.30.7-0.9-0.5-0.7-0.6-0.8-0.6-0.3-0.3-0.40.3
Time in open arm before self-admin0.20.21.10.60.10.20.20.40.10.2-0.2-0.2-1.0
Time in open arm after self-admin1.21.31.91.21.31.31.31.21.11.40.90.80.0
Bone: periosteal estimation1.43.03.8-1.8-1.5-1.9-1.9-1.7-1.9-1.3-2.0-1.9-1.3
Bone: periosteal perimeter2.95.06.7-1.9-1.6-2.3-2.6-2.2-2.5-1.9-2.5-2.5-1.9
Bone: post-yield work0.20.41.40.80.80.40.00.1-0.20.7-0.3-0.2-1.2
Progressive ratio test 1 active lever presses0.10.10.4-0.10.1-0.2-0.4-0.10.1-0.60.10.10.4
Progressive ratio test 1 breakpoint0.10.10.5-0.10.0-0.3-0.4-0.00.1-0.70.10.00.4
Progressive ratio test 1 inactive lever presses0.30.51.00.50.80.80.50.60.60.30.80.81.0
Progressive ratio test 2 active lever presses0.20.20.6-0.2-0.3-0.5-0.80.2-0.3-0.6-0.5-0.5-0.6
Progressive ratio test 2 breakpoint0.10.20.4-0.1-0.1-0.4-0.70.3-0.2-0.5-0.3-0.4-0.6
Progressive ratio test 2 inactive lever presses0.10.10.20.50.40.3-0.00.30.3-0.30.20.1-0.3
Incentive Sensitization - Responses0.81.13.8-0.4-0.6-0.8-1.2-0.1-0.9-0.4-1.2-1.3-2.0
Incentive Sensitization - Breakpoint0.81.14.0-0.4-0.6-0.8-1.3-0.2-0.9-0.4-1.2-1.3-2.0
Sum of active levers in priming session hrs 5-61.11.02.5-0.5-0.6-1.0-1.1-0.6-0.6-1.6-1.1-1.3-1.1
Progressive ratio1.42.23.1-1.6-1.8-1.6-1.4-1.5-1.7-0.9-1.6-1.5-1.0
Food seeking constrained by brief footshock0.81.02.2-0.7-0.2-0.8-1.2-0.9-1.2-0.1-1.2-1.5-1.2
Seeking ratio, punishment vs. effort0.10.21.00.61.00.4-0.10.10.10.30.0-0.2-0.5
Retroperitoneal fat weight0.83.37.9-2.8-2.7-2.1-1.7-1.7-1.7-1.0-1.4-1.10.8
Reaction time number correct0.10.20.9-0.30.1-0.10.3-0.4-0.10.00.20.41.0
Reaction time mean minus median0.30.71.9-0.7-0.3-0.9-0.9-1.4-0.8-1.2-0.6-0.9-0.1
Reaction time mean minus median AUC0.51.21.9-1.2-0.6-1.2-1.2-1.4-1.1-1.3-0.9-1.2-0.1
Reaction time num false alarms1.21.72.61.51.21.51.61.41.41.11.21.40.5
Reaction time num false alarms AUC1.42.33.41.81.61.71.81.51.51.31.41.60.4
Reaction time trials correct on left0.10.20.9-0.30.1-0.10.3-0.4-0.10.00.20.41.0
Reaction time trials on left0.10.21.0-0.30.1-0.10.3-0.4-0.10.00.20.41.0
Reaction time mean0.30.41.40.10.1-0.5-0.4-0.5-0.3-0.8-0.6-1.0-1.2
Reaction time mean AUC0.10.20.80.40.4-0.10.0-0.10.1-0.3-0.1-0.5-0.9
Median of all reaction times0.20.31.70.50.4-0.1-0.00.00.1-0.3-0.3-0.7-1.3
Reaction time omissions0.30.41.00.10.50.50.60.50.60.60.70.61.0
Reaction time false alarm rate1.11.52.51.61.21.51.41.51.31.11.01.2-0.0
Reaction time premature initiation rate0.10.20.80.40.70.50.1-0.1-0.00.90.1-0.1-0.4
Reaction time premature initiations0.10.10.4-0.10.50.2-0.0-0.4-0.20.70.1-0.10.1
Std. dev. reaction times0.10.30.7-0.30.0-0.5-0.4-0.7-0.4-0.9-0.4-0.7-0.3
Reaction time trials completed0.10.21.0-0.30.1-0.10.3-0.4-0.10.00.20.41.0
Reaction time trials AUC0.10.20.8-0.10.20.10.5-0.40.10.10.30.50.9
Run reversals in cocaine runway, females0.60.63.4-0.6-0.30.20.30.90.6-0.10.70.81.8
Run reversals in cocaine runway, males2.42.45.7-0.4-0.6-1.3-1.6-1.5-1.6-1.4-1.8-1.9-2.4
Latency to leave start box in cocaine runway1.61.82.81.71.61.51.41.51.71.11.21.00.1
Latency to leave start box in cocaine runway, F1.92.23.51.31.11.51.61.71.91.31.61.51.2
Latency to leave start box in cocaine runway, M0.50.51.71.01.30.60.30.40.40.30.2-0.1-1.0
Std. dev. time between licks in bursts0.00.00.2-0.10.2-0.0-0.10.30.20.40.1-0.1-0.2
Total sessions with >9 infusions0.20.20.9-0.20.50.20.10.40.50.30.50.30.9
Short access day 1 total inactive lever presses0.20.31.5-0.90.1-0.3-0.4-0.2-0.00.00.30.11.2
Short access day 10 total inactive lever presses0.30.71.1-0.9-0.8-0.9-1.0-1.0-0.90.1-1.0-1.0-0.7
Short access day 1 total infusions0.40.51.20.31.10.70.50.50.70.60.90.60.7
Short access day 10 total infusions0.50.71.6-1.0-0.4-1.0-1.0-0.7-0.8-1.3-0.6-0.60.0
Short access total infusions0.10.10.3-0.30.4-0.1-0.20.20.3-0.20.3-0.00.6
Short access day 1 locomotion0.60.74.1-0.60.30.30.50.30.50.70.90.92.0
Short access day 10 total locomotion0.81.52.2-1.2-0.9-1.3-1.5-1.5-1.0-1.3-1.1-1.3-0.6
Short access total locomotion0.60.72.0-1.4-0.8-1.0-0.9-0.8-0.6-0.7-0.4-0.50.9
One hour access (0.3 mA shock)0.20.30.60.70.70.70.30.50.50.40.50.40.1
Compulsive drug intake5.46.48.42.02.02.62.82.92.52.42.62.82.4
One hour access (shock baseline)0.50.83.40.10.1-0.4-1.0-0.6-0.7-0.7-0.9-1.1-1.8
Social response proportion0.20.31.11.10.70.40.50.10.30.10.20.3-0.6
Social responses0.20.21.10.40.3-0.20.0-0.3-0.4-0.4-0.4-0.3-1.0
Social time0.30.41.50.90.80.10.20.0-0.2-0.7-0.3-0.2-1.2
Soleus weight0.82.54.5-2.1-2.0-1.7-1.5-1.7-1.5-1.5-1.4-1.20.1
Bone: stiffness0.30.42.20.40.5-0.1-0.4-0.4-0.60.2-0.7-0.7-1.5
Tibialis anterior weight0.82.74.1-1.9-2.0-1.8-1.6-1.7-1.7-1.9-1.4-1.10.3
Time to tail flick, vehicle, before self-admin0.10.10.4-0.3-0.1-0.0-0.10.2-0.00.7-0.1-0.00.1
Time to tail flick, vehicle, after self-admin0.70.92.4-1.6-1.3-1.2-0.8-0.8-0.9-0.8-0.8-0.70.4
Time to tail flick, test, before self-admin0.20.20.50.00.60.0-0.2-0.6-0.20.1-0.2-0.5-0.7
Time to tail flick, test, after self-admin0.20.30.5-0.3-0.7-0.5-0.5-0.2-0.4-0.4-0.7-0.4-0.7
Delta time to tail flick, vehicle, before/after SA0.40.41.2-0.8-0.8-0.7-0.4-0.5-0.4-1.1-0.3-0.30.4
Delta time to tail flick, test, before/after SA0.10.10.5-0.4-0.7-0.10.10.30.10.2-0.00.40.5
Tibia length0.10.41.1-0.7-0.9-0.4-0.4-0.7-0.5-1.0-0.30.10.7
Ambulatory time before self-admin1.01.52.1-1.3-1.1-1.4-1.5-1.2-1.3-1.3-1.1-1.2-0.3
Ambulatory time after self-admin0.10.10.50.20.00.20.10.20.0-0.60.30.40.7
Bone: tissue strength0.10.10.2-0.3-0.2-0.3-0.3-0.4-0.4-0.4-0.2-0.20.2
Total heroin consumption0.91.14.70.2-0.3-0.7-0.9-0.3-0.4-1.1-1.1-1.4-2.2
Bone: trabecular number1.42.33.82.01.71.71.41.81.51.81.11.1-0.5
Bone: trabecular spacing0.20.21.1-0.8-0.4-0.4-0.1-0.4-0.1-0.20.00.11.0
Bone: trabecular thickness0.50.62.6-0.5-0.40.30.50.90.40.40.71.01.6
Bone: trabecular tissue density1.32.03.3-1.8-1.8-1.6-1.6-1.3-1.4-1.3-1.1-1.20.3
Water consumed over 24 hours0.10.21.10.70.60.20.0-0.1-0.0-0.1-0.2-0.3-1.0
Number of responses in last shaping day0.30.30.8-0.9-0.3-0.7-0.4-0.9-0.8-0.5-0.3-0.20.5