Hub : Genes

Pld4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Pld4 0.09 0.06 1.1e-11 0.08 0.08 0.08 0.08 2.3e-12 8.4e-12 1.3e-11 7.8e-12
2 Adipose mRNA stability Pld4 0.2 0.12 8.4e-13 0.1 0.11 0.1 0.1 2.1e-11 3.0e-12 2.2e-11 2.0e-11
3 pVTA mRNA stability Pld4 0.28 0.13 0.0e+00 0.24 0.25 0.26 0.26 1.1e-19 6.5e-20 2.6e-21 7.2e-21
4 Brain mRNA stability Pld4 0.25 0.15 1.2e-11 0.12 0 0.1 0.01 3.3e-11 3.1e-01 7.2e-10 1.3e-02
5 BLA mRNA stability Pld4 0.16 0.11 3.3e-05 0.07 0.08 0.08 0.08 8.3e-05 4.2e-05 6.5e-05 7.2e-05
6 NAcc intron excision ratio chr6_137641756_137642398 0.02 0.02 4.9e-03 0.01 0.01 0.01 0.01 4.4e-03 2.2e-02 1.2e-02 1.5e-02
7 NAcc intron excision ratio chr6_137640072_137641670 0.06 0.04 1.2e-05 0.03 0.03 0.03 0.03 8.0e-06 1.1e-05 1.4e-05 1.9e-05
8 IC mRNA stability Pld4 0.25 0.13 2.1e-07 0.19 0.18 0.18 0.19 1.4e-08 3.8e-08 3.1e-08 1.8e-08
9 pVTA isoform ratio XM_039112594.2 0.03 0.03 4.0e-03 0.01 0.02 0.02 0.02 2.2e-02 7.1e-03 1.1e-02 1.3e-02
10 PL intron excision ratio chr6_137640072_137641670 0.03 0.02 5.2e-04 0.02 0.03 0.03 0.02 9.9e-04 2.9e-04 9.4e-04 1.1e-03
11 Liver gene expression Pld4 0.18 0.11 1.6e-13 0.12 0.1 0.1 0.11 1.1e-12 3.4e-11 4.6e-11 1.5e-12
12 PL mRNA stability Pld4 0.15 0.1 1.7e-09 0.1 0.08 0.1 0.09 6.0e-11 1.8e-09 1.2e-10 1.9e-10
13 Brain intron excision ratio chr6_137640072_137641670 0.04 0.03 1.5e-04 0.04 0.02 0.04 0.02 1.0e-04 3.9e-03 1.9e-04 2.2e-03
14 pVTA isoform ratio NM_001126288.1 0.03 0.02 8.6e-03 0.02 0.01 0.01 0.01 1.8e-02 1.9e-02 7.2e-02 3.4e-02
15 pVTA intron excision ratio chr6_137640072_137641670 0.03 0.03 5.0e-03 0.03 0.02 0.03 0.03 3.7e-03 4.7e-03 3.8e-03 3.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.10.20.50.30.50.50.30.3-0.50.50.5-0.30.20.70.70.30.40.4
Area under the delay curve1.31.53.1-1.4-1.8-1.3-1.3-1.41.5-1.5-1.51.2-1.1-0.8-0.8-0.9-0.5-0.5
BMI with tail2.89.610.7-3.1-2.6-3.3-3.1-3.03.3-3.3-3.23.2-3.3-3.0-3.1-2.9-3.0-3.0
BMI without tail1.75.36.3-2.5-2.1-2.4-2.5-2.42.5-2.5-2.52.4-2.5-2.2-2.3-1.8-2.0-2.0
Body weight1.25.16.92.32.42.32.22.3-2.12.12.2-2.22.12.32.22.62.32.3
Weight adjusted by age0.30.50.80.80.60.80.70.6-0.60.60.6-0.70.70.50.60.80.90.9
Bone surface0.10.20.4-0.5-0.6-0.4-0.5-0.50.5-0.5-0.50.5-0.4-0.2-0.2-0.4-0.2-0.2
Bone volume0.10.10.3-0.5-0.6-0.3-0.4-0.40.4-0.4-0.40.4-0.3-0.2-0.2-0.4-0.1-0.1
Breakpoint value in progressive ratio session0.50.61.70.91.30.70.90.8-0.90.90.9-0.60.40.60.70.50.10.1
Number of licking bursts0.81.22.2-1.1-1.5-1.1-1.2-1.21.1-1.1-1.11.0-0.9-1.1-1.1-1.1-0.8-0.8
Context. condit. distance diff. score3.34.04.82.21.82.02.02.1-1.91.91.9-2.12.21.91.91.82.12.1
Locomotion velocity, session 10.20.20.30.50.40.50.50.4-0.50.50.5-0.40.40.40.40.40.50.5
Locomotion distance, session 10.10.10.4-0.20.0-0.3-0.3-0.40.2-0.2-0.20.5-0.6-0.2-0.2-0.3-0.6-0.6
Locomotion velocity, session 20.20.30.6-0.6-0.8-0.5-0.6-0.60.5-0.5-0.50.5-0.4-0.7-0.7-0.6-0.3-0.3
Locomotion distance, session 20.60.91.1-0.9-1.0-1.0-0.9-1.01.0-1.0-1.00.9-0.9-1.1-1.1-1.0-0.7-0.7
Locomotion velocity, session 30.00.00.00.10.20.00.2-0.1-0.20.20.10.1-0.20.00.0-0.1-0.2-0.2
Locomotion distance, session 30.00.00.1-0.1-0.2-0.1-0.2-0.20.1-0.1-0.10.1-0.1-0.2-0.2-0.4-0.2-0.2
Stereotopy head waving bouts, day 30.00.00.10.20.20.10.30.2-0.00.00.1-0.20.20.20.20.00.10.1
Stereotopy head waving duration, day 30.10.10.20.30.20.30.40.3-0.20.20.2-0.40.40.30.30.30.40.4
Locomotion velocity, session 70.10.10.40.30.60.20.30.2-0.30.30.3-0.1-0.00.10.10.4-0.3-0.3
Locomotion distance, session 70.81.01.3-1.0-1.0-1.0-1.0-1.00.9-0.9-0.91.0-1.0-1.1-1.1-0.7-1.1-1.1
Stereotopy head waving bouts, day 72.73.03.91.61.81.81.81.7-1.81.81.8-1.61.52.02.01.61.61.6
Stereotopy head waving duration, day 71.82.22.91.41.61.51.61.4-1.61.61.6-1.41.21.71.71.21.21.2
Locomotion velocity, session 82.12.53.31.81.81.61.71.7-1.61.61.6-1.71.61.51.51.41.31.3
Locomotion distance, session 80.40.51.01.00.80.70.80.8-0.70.70.6-0.80.80.70.70.60.70.7
Degree of sensitization distance0.20.20.3-0.5-0.4-0.4-0.5-0.50.5-0.5-0.50.5-0.5-0.4-0.40.0-0.3-0.3
Degree of sensitization stereotypy1.21.31.71.01.31.21.21.1-1.31.31.2-1.11.01.31.31.01.01.0
Conditioned locomotion1.82.12.61.51.41.51.41.4-1.51.51.5-1.41.41.41.41.61.41.4
Cocaine response after cond. corrected0.10.10.50.30.70.10.20.0-0.20.20.30.2-0.40.20.20.0-0.5-0.5
Cocaine response after cond. not corrected0.50.51.4-0.30.1-0.7-0.5-0.60.5-0.5-0.50.8-1.0-0.7-0.6-0.8-1.2-1.2
Cocaine response before conditioning3.44.14.9-2.0-2.0-2.1-2.1-1.92.1-2.1-2.21.9-1.8-2.2-2.2-2.2-1.8-1.8
Saline control response0.20.30.40.70.60.60.60.5-0.60.60.6-0.50.40.50.50.40.40.4
Bone: connectivity density0.60.91.40.80.91.00.90.9-0.90.90.9-0.90.81.21.20.90.90.9
Bone: cortical apparent density4.15.68.12.41.62.42.12.3-2.22.22.2-2.52.72.32.22.62.82.8
Bone: cortical area0.20.30.60.80.60.60.60.5-0.50.50.5-0.50.50.60.60.40.50.5
Bone: cortical porosity0.50.50.70.70.50.70.80.8-0.70.70.7-0.80.80.70.60.40.70.7
Bone: cortical porosity0.10.10.20.40.50.30.50.5-0.30.30.3-0.40.40.30.2-0.20.10.1
Bone: cortical thickness1.01.72.51.51.61.41.31.3-1.41.41.4-1.21.01.41.41.31.01.0
Bone: cortical thickness0.70.81.10.90.60.91.00.8-0.90.90.9-0.90.90.80.80.91.11.1
Bone: cortical tissue density3.95.37.82.31.62.32.12.3-2.12.12.1-2.42.62.22.12.52.82.8
Condit. Reinf. active minus inactive responses0.10.20.4-0.5-0.2-0.3-0.4-0.50.3-0.3-0.30.6-0.7-0.2-0.2-0.1-0.4-0.4
Condit. Reinf. active-inactive response ratio1.51.62.3-1.3-0.8-1.3-1.2-1.31.2-1.2-1.21.4-1.5-1.1-1.1-1.1-1.4-1.4
Condit. Reinf. active responses0.10.20.40.20.70.40.40.3-0.40.40.4-0.20.00.50.50.50.10.1
Condit. Reinf. inactive responses2.53.03.51.81.81.81.91.7-1.91.91.8-1.71.61.81.81.71.51.5
Incentive salience index mean0.10.10.40.00.60.10.20.1-0.20.20.10.1-0.30.30.30.4-0.2-0.2
Condit. Reinf. lever presses0.20.31.20.51.10.40.60.6-0.50.50.4-0.40.20.50.50.3-0.1-0.1
Condit. Reinf. active minus inactive responses0.40.61.30.70.30.70.50.6-0.60.60.6-0.80.80.60.61.01.11.1
Condit. Reinf. active-inactive response ratio0.20.30.90.4-0.10.50.20.3-0.30.30.3-0.40.60.30.30.91.01.0
Condit. Reinf. active responses0.00.00.1-0.1-0.4-0.1-0.3-0.10.1-0.1-0.20.00.0-0.2-0.2-0.00.30.3
Condit. Reinf. inactive responses0.40.61.0-0.8-0.7-0.8-0.8-0.70.7-0.7-0.70.7-0.8-0.7-0.6-1.0-0.8-0.8
Condit. Reinf. lever presses2.53.54.6-1.9-2.1-1.9-2.0-1.91.9-1.9-1.91.8-1.7-2.0-1.9-1.9-1.6-1.6
Condit. Reinf. lever reinforcers received0.00.00.2-0.1-0.40.0-0.2-0.10.1-0.1-0.1-0.00.1-0.1-0.10.10.40.4
Conditioned reinforcement - actives0.10.20.50.30.00.40.30.3-0.30.30.3-0.40.50.20.20.30.70.7
Conditioned reinforcement - inactives0.40.61.10.50.70.80.80.7-0.70.70.8-0.70.70.80.81.00.80.8
Conditioned locomotion0.00.00.10.20.40.10.20.1-0.20.20.2-0.1-0.1-0.0-0.00.10.00.0
Patch foraging indifference point 0 sec6.411.912.83.53.63.53.53.6-3.53.53.6-3.53.33.53.53.33.13.1
Patch foraging indifference point AUC4.86.910.72.83.32.62.82.8-2.72.72.8-2.52.32.92.92.51.81.8
Delay disc. indifference point, 0s delay0.30.30.70.40.30.50.60.4-0.40.40.3-0.50.50.70.70.70.80.8
Delay disc. indifference point, 16s delay1.82.03.7-1.5-1.9-1.4-1.5-1.61.6-1.6-1.71.4-1.2-1.3-1.3-1.2-0.8-0.8
Delay disc. indifference point, 2s delay3.64.06.8-2.3-2.6-2.1-2.1-2.22.3-2.3-2.32.0-1.7-1.8-1.8-1.8-1.0-1.0
Delay disc. indifference point, 24s delay1.21.32.1-1.2-1.4-1.2-1.2-1.31.4-1.4-1.31.2-1.1-0.9-0.9-1.0-0.7-0.7
Delay disc. indifference point, 4s delay0.50.51.9-0.9-1.4-0.6-0.7-0.80.9-0.9-0.90.5-0.3-0.4-0.4-0.40.30.3
Delay disc. indifference point, 8s delay0.50.61.3-0.9-1.1-0.8-0.8-0.90.9-0.9-1.00.8-0.7-0.3-0.3-0.4-0.4-0.4
Indifference point function ln k0.20.41.10.5-0.00.60.40.6-0.50.50.4-0.70.90.30.30.61.11.1
Indifference point function log k0.20.41.10.5-0.00.60.40.6-0.50.50.4-0.70.90.30.30.61.11.1
Patch foraging total patch changes 0 sec7.313.815.03.83.93.83.83.8-3.83.83.9-3.73.63.73.83.53.33.3
Patch foraging total patch changes 12 sec4.35.57.52.32.12.42.32.3-2.32.32.4-2.32.32.72.72.22.22.2
Patch foraging total patch changes 18 sec2.23.44.81.82.01.91.91.9-1.81.81.9-1.81.62.22.21.91.51.5
Patch foraging total patch changes 24 sec1.01.72.81.41.71.21.51.4-1.31.31.3-1.31.11.41.41.00.90.9
Patch foraging total patch changes 6 sec6.610.014.93.43.93.23.33.3-3.33.33.4-3.12.83.43.42.72.32.3
Patch foraging time to switch 0 sec8.918.320.4-4.5-4.1-4.4-4.3-4.44.2-4.2-4.34.4-4.3-4.1-4.0-4.4-4.2-4.2
Patch foraging water rate 0 sec14.029.432.05.75.05.65.45.5-5.45.45.5-5.65.65.15.25.35.55.5
Patch foraging water rate 12 sec4.18.613.52.81.83.02.72.9-2.82.82.7-3.13.42.52.43.23.73.7
Patch foraging water rate 18 sec3.04.66.32.31.62.22.12.2-2.02.02.0-2.42.51.71.72.12.52.5
Patch foraging water rate 24 sec2.23.14.51.91.21.81.81.8-1.71.71.6-2.02.11.21.21.72.12.1
Patch foraging water rate 6 sec4.05.86.72.62.02.52.52.5-2.42.42.4-2.62.62.12.12.22.52.5
Seeking ratio, delayed vs. immediate footshock0.20.30.40.60.40.60.30.5-0.50.50.5-0.50.60.20.20.40.70.7
Distance traveled before self-admin0.60.70.9-0.8-0.8-0.8-0.9-0.90.9-0.9-0.80.9-0.9-1.0-1.0-0.9-0.6-0.6
Distance traveled after self-admin0.10.10.50.2-0.10.30.10.2-0.10.10.2-0.30.40.20.40.30.70.7
Extensor digitorum longus weight9.537.540.46.25.96.36.46.2-6.26.26.2-6.26.26.05.95.86.06.0
Bone: elastic displacement0.10.10.5-0.4-0.70.1-0.2-0.20.0-0.0-0.00.00.1-0.0-0.00.10.40.4
Bone: elastic work0.50.72.0-1.1-1.4-0.7-1.0-0.90.9-0.9-0.90.7-0.5-0.7-0.7-0.7-0.2-0.2
Bone: endosteal estimation1.53.46.2-2.0-2.5-1.9-1.9-1.92.0-2.0-2.01.6-1.4-1.9-1.9-1.8-1.2-1.2
Bone: endosteal perimeter0.30.50.9-0.6-0.8-0.8-0.6-0.70.8-0.8-0.80.6-0.6-0.7-0.7-1.0-0.6-0.6
Epididymis fat weight2.17.09.1-2.8-2.1-2.8-2.8-2.72.7-2.7-2.72.9-3.0-2.3-2.3-2.1-2.8-2.8
Delta time in closed arm before/after self-admin0.00.00.20.0-0.00.10.10.1-0.10.10.0-0.10.1-0.4-0.4-0.3-0.0-0.0
Delta time in open arm before/after self-admin1.31.31.71.21.31.21.11.1-1.11.11.2-1.00.91.21.21.21.01.0
Diff in mean of infusions in LGA sessions0.80.92.61.31.60.91.21.0-1.21.21.2-0.80.60.60.60.60.20.2
Delay discount exponential model param1.21.32.81.31.71.21.21.3-1.41.41.5-1.21.00.70.70.80.40.4
Extinction: sum of active levers before priming0.20.20.70.30.80.10.30.2-0.30.30.30.0-0.20.70.60.4-0.4-0.4
Active lever presses in extinction session 61.71.71.91.41.11.31.21.3-1.21.21.3-1.41.41.21.31.31.31.3
Bone: final force0.20.30.9-0.5-1.0-0.5-0.6-0.50.6-0.6-0.60.3-0.2-0.6-0.6-0.7-0.2-0.2
Bone: final moment0.10.10.5-0.3-0.7-0.3-0.4-0.30.4-0.4-0.40.2-0.0-0.4-0.4-0.5-0.0-0.0
Food consumed during 24 hour testing period0.81.11.51.11.01.01.01.0-1.01.00.9-1.01.01.01.01.21.01.0
Glucose0.10.20.70.0-0.20.40.10.1-0.20.20.3-0.20.30.40.40.50.80.8
Heart weight0.30.50.80.60.40.70.70.7-0.60.60.6-0.70.80.60.60.70.90.9
Delay discount hyperbolic model param1.31.53.11.41.81.31.31.4-1.51.51.5-1.21.10.80.80.80.40.4
Intermittent access intake day 1-15 change1.32.73.6-1.6-1.3-1.7-1.6-1.71.6-1.6-1.51.7-1.8-1.6-1.6-1.5-1.9-1.9
Intermittent access intake escalation1.32.73.5-1.7-1.3-1.7-1.7-1.71.6-1.6-1.61.8-1.9-1.5-1.5-1.4-1.8-1.8
Intermittent access intake escalation 20.70.81.3-1.0-0.6-0.9-0.9-1.00.8-0.8-0.81.1-1.2-0.7-0.7-0.8-1.1-1.1
Intermitt. access day 1 inactive lever presses0.31.12.40.91.01.11.11.0-1.01.01.1-1.00.91.31.31.50.80.8
Intermitt. access day 15 inactive lever presses1.83.75.31.81.61.91.81.8-1.81.81.8-1.81.82.22.22.32.02.0
Intermitt. access escalation Index0.30.40.80.70.30.70.60.6-0.60.60.6-0.80.90.30.30.10.80.8
Intermittent access day 1 total infusions0.10.10.2-0.0-0.0-0.3-0.2-0.20.3-0.3-0.30.3-0.4-0.4-0.4-0.3-0.3-0.3
Intermittent access day 15 total infusions1.01.51.9-1.0-0.9-1.3-1.2-1.21.2-1.2-1.21.3-1.4-1.3-1.3-1.0-1.2-1.2
Intermittent access terminal intake (last 3 days)1.21.62.3-1.2-1.0-1.3-1.2-1.41.2-1.2-1.21.4-1.5-1.2-1.2-1.0-1.3-1.3
Intermittent access total infusions0.30.40.6-0.4-0.4-0.7-0.6-0.60.6-0.6-0.60.7-0.8-0.8-0.8-0.5-0.6-0.6
Intermittent access day 1 locomotion0.40.51.0-0.4-0.1-0.7-0.6-0.60.6-0.6-0.60.8-0.9-0.9-0.9-0.8-1.0-1.0
Intermittent access day 15 total locomotion0.61.11.5-1.0-1.0-1.0-1.0-1.01.0-1.0-1.01.0-0.9-1.2-1.2-1.2-1.0-1.0
Intermittent access total locomotion0.20.20.4-0.2-0.1-0.4-0.4-0.40.3-0.3-0.30.5-0.6-0.5-0.5-0.5-0.6-0.6
Intermittent access standard deviation0.20.31.0-0.20.4-0.4-0.2-0.40.2-0.2-0.20.6-0.9-0.5-0.5-0.4-1.0-1.0
Left kidney weight2.210.411.83.33.13.33.23.4-3.23.23.2-3.43.43.13.13.13.33.3
Right kidney weight1.67.38.42.82.62.72.72.9-2.62.62.7-2.92.92.42.42.62.82.8
Cocaine induced anxiety0.71.01.41.00.81.01.11.0-1.11.11.1-1.11.20.90.90.70.80.8
Post-drug Anxiety1.81.92.51.31.01.51.41.4-1.41.41.4-1.51.61.41.41.21.31.3
Baseline Anxiety0.10.10.2-0.3-0.5-0.3-0.4-0.40.4-0.4-0.40.4-0.3-0.2-0.2-0.3-0.1-0.1
Tail length5.622.125.14.64.24.84.64.7-4.74.74.6-4.74.74.74.75.04.94.9
Length with tail10.043.647.16.66.36.86.66.6-6.66.66.7-6.66.56.66.66.96.56.5
Length without tail6.019.221.34.64.64.54.44.5-4.44.44.5-4.44.34.44.44.44.04.0
Times rat made contact with spout0.40.50.80.70.70.70.60.6-0.70.70.7-0.50.50.90.90.80.50.5
Lifetime Intake0.40.50.7-0.5-0.6-0.7-0.8-0.70.7-0.7-0.70.7-0.7-0.8-0.8-0.4-0.5-0.5
Liver weight, left3.55.96.42.52.32.42.32.5-2.42.42.4-2.42.42.52.52.42.42.4
Liver weight, right0.00.10.20.30.50.10.10.2-0.20.20.2-0.1-0.00.20.2-0.0-0.2-0.2
Locomotor activity0.10.10.20.50.20.40.30.4-0.40.40.4-0.40.50.10.20.20.40.4
Locomotor testing distance0.00.10.20.40.10.30.20.3-0.20.20.3-0.40.50.10.20.20.40.4
Locomotor testing rearing1.83.64.6-1.6-1.5-2.0-1.8-1.81.8-1.8-1.81.9-1.9-2.0-2.0-1.9-2.1-2.1
Locomotion in novel chamber1.82.24.31.30.61.41.31.3-1.21.21.2-1.61.71.71.41.72.12.1
Locomotion in novel chamber post-restriction0.10.10.3-0.5-0.5-0.3-0.3-0.30.3-0.3-0.30.3-0.3-0.4-0.5-0.3-0.2-0.2
Fecal boli incidents, locomotor time 10.20.30.9-0.50.2-0.6-0.5-0.50.4-0.4-0.40.7-0.9-0.1-0.0-0.5-0.9-0.9
Change in fecal boli incidents, locomotor task0.70.71.31.10.40.80.90.9-0.80.80.7-1.01.20.40.40.70.90.9
Time >=10cm from walls, locomotor time 11.92.16.01.72.41.31.71.6-1.71.71.6-1.31.01.21.21.10.20.2
Bouts of movement, locomotor time 11.01.11.8-1.3-0.9-1.1-1.1-1.20.9-0.9-1.01.3-1.4-0.6-0.5-0.8-1.1-1.1
Total resting periods, locomotor time 11.31.42.3-1.5-1.1-1.2-1.3-1.41.1-1.1-1.21.4-1.4-0.7-0.6-0.9-1.2-1.2
Rest time, locomotor task time 10.50.71.5-1.0-1.2-0.8-1.0-0.90.9-0.9-0.90.8-0.7-0.6-0.5-0.6-0.4-0.4
Distance moved, locomotor task time 10.40.51.1-0.5-0.8-0.7-0.7-0.70.7-0.7-0.80.7-0.6-0.9-1.0-0.8-0.6-0.6
Vertical activity count, locomotor time 10.00.00.1-0.0-0.20.00.1-0.0-0.10.1-0.0-0.10.2-0.3-0.3-0.10.00.0
Time >=10cm from walls, locomotor time 21.72.54.41.72.11.51.81.7-1.81.81.7-1.51.31.81.71.60.70.7
Bouts of movement, locomotor time 20.10.21.0-0.0-1.0-0.1-0.3-0.10.4-0.4-0.5-0.10.4-0.00.10.20.80.8
Total resting periods, locomotor time 20.20.31.4-0.2-1.2-0.3-0.5-0.30.6-0.6-0.60.00.2-0.2-0.10.00.70.7
Rest time, locomotor task time 20.10.20.5-0.5-0.7-0.3-0.4-0.40.6-0.6-0.50.3-0.2-0.1-0.1-0.10.30.3
Distance moved, locomotor task time 20.20.30.6-0.2-0.3-0.4-0.4-0.50.3-0.3-0.30.5-0.5-0.6-0.7-0.6-0.8-0.8
Vertical activity count, locomotor time 20.20.30.50.70.60.50.70.5-0.70.70.6-0.50.50.20.10.3-0.1-0.1
Light reinforcement 10.00.00.10.10.1-0.00.20.2-0.00.0-0.1-0.20.2-0.1-0.1-0.3-0.1-0.1
Light reinforcement 21.11.82.5-1.2-0.8-1.3-1.2-1.21.2-1.2-1.21.4-1.4-1.5-1.5-1.3-1.6-1.6
Bone: marrow area1.53.25.9-1.9-2.4-1.8-1.9-1.81.9-1.9-1.91.6-1.3-1.8-1.8-1.8-1.1-1.1
Bone: maximum diameter0.10.30.5-0.2-0.3-0.6-0.4-0.50.5-0.5-0.50.5-0.6-0.5-0.5-0.7-0.6-0.6
Bone: maximum force0.00.00.1-0.2-0.3-0.2-0.3-0.10.3-0.3-0.30.10.0-0.0-0.1-0.20.00.0
Bone: maximum moment0.00.00.00.0-0.1-0.0-0.10.10.1-0.1-0.1-0.10.10.20.10.00.20.2
Mean time between licks in bursts0.30.81.1-1.0-1.0-0.9-1.1-0.90.9-0.9-0.90.9-0.9-1.0-1.0-0.9-0.8-0.8
Mean num. licks in bursts1.32.03.31.51.81.41.51.4-1.51.51.5-1.31.11.51.61.51.01.0
Cd content in liver0.10.10.3-0.2-0.6-0.1-0.2-0.20.3-0.3-0.30.10.1-0.2-0.20.20.40.4
Co content in liver1.01.21.71.00.61.11.00.9-1.01.01.0-1.01.11.21.21.31.21.2
Cu content in liver1.61.92.1-1.3-1.2-1.4-1.3-1.41.4-1.4-1.41.4-1.4-1.4-1.4-1.4-1.4-1.4
Fe content in liver0.60.80.9-0.8-0.9-0.9-0.8-0.90.8-0.8-0.80.9-0.8-1.0-1.0-0.9-0.8-0.8
K content in liver0.60.60.80.90.90.80.90.8-0.90.90.9-0.80.80.70.70.50.60.6
Mg content in liver0.10.10.20.20.10.20.20.3-0.20.20.2-0.30.40.20.20.00.30.3
Mn content in liver0.00.00.2-0.1-0.2-0.2-0.2-0.10.2-0.2-0.20.00.0-0.2-0.2-0.4-0.1-0.1
Na content in liver0.40.40.9-0.5-0.2-0.6-0.5-0.50.5-0.5-0.50.6-0.7-0.7-0.7-0.9-0.9-0.9
Rb content in liver0.30.40.60.60.20.60.60.6-0.60.60.6-0.70.80.50.50.30.70.7
Se content in liver0.10.10.2-0.4-0.4-0.4-0.3-0.40.4-0.4-0.40.4-0.3-0.4-0.4-0.5-0.4-0.4
Sr content in liver0.10.10.4-0.2-0.7-0.2-0.2-0.40.2-0.2-0.20.2-0.1-0.4-0.4-0.10.10.1
Zn content in liver0.20.20.80.3-0.10.50.30.3-0.30.30.3-0.40.50.40.40.50.90.9
Bone: minimum diameter0.40.71.10.90.60.80.80.8-0.70.70.7-0.91.00.80.80.71.11.1
Time in familiar zone, hab. session 10.00.00.00.10.10.10.20.0-0.20.20.2-0.00.00.20.20.10.00.0
Time in novel zone, hab. session 11.01.01.3-0.9-1.1-1.0-1.1-1.01.0-1.0-1.10.9-0.9-1.1-1.1-1.1-0.8-0.8
Total zone transitions, hab. session 10.60.91.4-0.9-1.1-1.0-1.0-0.91.0-1.0-1.10.8-0.7-0.9-0.9-1.2-0.6-0.6
Total locomotion distance, hab. session 10.10.10.3-0.0-0.50.0-0.10.00.1-0.1-0.1-0.20.40.00.0-0.20.50.5
Locomotion velocity, hab. session 10.30.40.90.60.20.60.50.6-0.50.50.5-0.80.90.70.70.30.90.9
Time in familiar zone, hab. session 20.50.61.71.01.30.70.90.8-0.80.80.9-0.60.40.80.80.50.00.0
Time in novel zone, hab. session 21.01.02.0-1.2-1.4-1.0-1.1-1.11.1-1.1-1.11.0-0.8-1.0-1.0-1.0-0.5-0.5
Total zone transitions, hab. session 20.10.10.3-0.2-0.0-0.2-0.2-0.40.1-0.1-0.20.4-0.6-0.1-0.1-0.2-0.4-0.4
Total locomotion distance, hab. session 20.30.40.70.60.30.70.60.5-0.60.60.6-0.60.60.80.80.70.80.8
Locomotion velocity, hab. session 20.50.60.90.80.50.80.70.7-0.80.80.8-0.70.70.90.90.90.90.9
Novel to familiar place preference ratio0.60.71.2-1.0-0.9-0.7-0.8-1.00.6-0.6-0.70.9-0.9-0.8-0.8-1.1-0.9-0.9
Novelty place preference0.70.81.1-1.1-1.1-0.8-0.9-1.00.7-0.7-0.81.0-0.9-0.8-0.8-1.0-0.7-0.7
Time in novel zone, NPP test0.20.30.6-0.7-0.6-0.4-0.5-0.60.4-0.4-0.40.6-0.6-0.4-0.4-0.7-0.5-0.5
Total zone transitions, NPP test0.70.91.31.01.11.01.00.9-1.01.01.0-0.80.81.11.10.80.90.9
Total locomotion distance, NPP test0.40.60.80.70.60.80.70.7-0.70.70.8-0.70.70.90.90.60.80.8
Locomotion velocity, NPP test0.20.30.60.50.30.60.50.5-0.50.50.5-0.50.60.60.60.60.80.8
Intraocular pressure0.20.31.0-0.7-1.0-0.5-0.8-0.70.8-0.8-0.60.5-0.4-0.4-0.2-0.4-0.1-0.1
Delta distance traveled before/after self-admin0.00.00.10.10.00.20.10.2-0.10.10.1-0.20.20.20.30.30.30.3
Delta ambulatory time before/after self-admin0.40.51.10.50.20.70.50.6-0.50.50.5-0.70.80.70.90.91.11.1
Parametrial fat weight0.00.10.20.10.3-0.10.10.00.0-0.0-0.00.1-0.2-0.5-0.5-0.3-0.4-0.4
Pavlov. Cond. lever latency0.10.10.40.3-0.20.30.10.2-0.20.20.3-0.40.50.20.20.40.60.6
Pavlov. Cond. magazine entry latency0.00.00.20.10.4-0.10.00.10.1-0.1-0.10.1-0.20.20.20.0-0.4-0.4
Pavlov. Cond. change in total contacts0.00.00.20.10.50.00.20.1-0.10.10.00.0-0.10.20.2-0.0-0.2-0.2
Pavlov. Cond. index score0.10.10.4-0.10.4-0.2-0.1-0.10.2-0.2-0.20.3-0.50.00.0-0.2-0.6-0.6
Pavlov. Cond. latency score0.10.10.3-0.10.4-0.2-0.1-0.10.1-0.1-0.20.3-0.40.00.0-0.2-0.5-0.5
Pavlov. Cond. lever contacts0.40.51.0-0.6-0.1-0.7-0.5-0.60.6-0.6-0.70.7-0.9-0.5-0.5-0.7-1.0-1.0
Pavlov. Cond. magazine entry number0.00.10.3-0.1-0.50.1-0.0-0.1-0.10.10.1-0.10.3-0.2-0.20.00.40.4
Pavlov. Cond. intertrial magazine entries8.710.511.33.43.23.43.33.2-3.33.33.3-3.23.23.23.23.23.03.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.20.4-0.2-0.1-0.10.2-0.2-0.20.3-0.50.00.0-0.2-0.6-0.6
Pavlov. Cond. response bias0.10.10.50.10.7-0.10.10.1-0.00.0-0.00.2-0.40.20.2-0.1-0.6-0.6
Pavlov. Cond. lever latency3.24.45.62.22.42.12.32.2-2.22.22.1-2.12.02.02.01.91.81.8
Pavlov. Cond. magazine entry latency3.23.94.4-2.0-1.8-2.0-1.9-2.01.9-1.9-1.92.1-2.1-1.9-1.9-2.1-1.9-1.9
Pavlov. Cond. change in total contacts4.97.88.5-2.9-2.8-2.8-2.9-2.92.8-2.8-2.82.8-2.8-2.9-2.8-2.7-2.6-2.6
Pavlov. Cond. index score4.45.96.4-2.5-2.5-2.5-2.5-2.52.4-2.4-2.42.5-2.4-2.4-2.4-2.4-2.3-2.3
Pavlov. Cond. latency score4.05.35.7-2.4-2.2-2.3-2.3-2.42.3-2.3-2.22.4-2.4-2.2-2.2-2.3-2.4-2.4
Pavlov. Cond. lever contacts3.75.26.2-2.4-2.5-2.3-2.5-2.42.3-2.3-2.32.3-2.2-2.2-2.2-2.1-2.0-2.0
Pavlov. Cond. magazine entry number2.83.54.12.01.81.81.92.0-1.81.81.8-2.02.01.81.81.91.81.8
Pavlov. Cond. intertrial magazine entries3.85.77.52.31.92.42.22.4-2.32.32.2-2.52.62.32.32.52.72.7
Pavlov. Cond. lever-magazine prob. diff.5.16.87.3-2.7-2.6-2.6-2.7-2.72.6-2.6-2.62.7-2.6-2.6-2.6-2.6-2.5-2.5
Pavlov. Cond. response bias3.75.06.2-2.4-2.5-2.3-2.4-2.42.3-2.3-2.32.3-2.2-2.2-2.2-2.0-1.9-1.9
Time in closed arm before self-admin6.78.59.7-3.0-3.0-3.0-3.1-3.03.1-3.1-3.02.9-2.8-2.8-2.8-2.8-2.7-2.7
Time in closed arm after self-admin6.16.59.2-2.7-3.0-2.6-2.7-2.52.7-2.7-2.62.3-2.1-2.8-2.8-2.6-2.0-2.0
Time in open arm before self-admin4.75.15.82.22.02.42.42.3-2.42.42.2-2.42.42.02.12.12.22.2
Time in open arm after self-admin9.610.513.93.43.73.43.53.3-3.53.53.4-3.12.93.13.23.12.72.7
Bone: periosteal estimation0.30.61.5-0.7-1.2-0.7-0.8-0.80.9-0.9-0.90.6-0.5-0.7-0.7-0.8-0.2-0.2
Bone: periosteal perimeter0.00.00.20.0-0.0-0.2-0.1-0.10.2-0.2-0.20.1-0.2-0.1-0.2-0.4-0.2-0.2
Bone: post-yield work2.43.54.02.01.81.91.81.9-1.81.81.8-1.92.01.91.91.81.81.8
Progressive ratio test 1 active lever presses0.40.50.8-0.5-0.7-0.7-0.7-0.70.7-0.7-0.70.7-0.6-0.9-0.9-0.6-0.4-0.4
Progressive ratio test 1 breakpoint0.40.50.9-0.5-0.7-0.7-0.7-0.70.7-0.7-0.70.7-0.7-1.0-1.0-0.6-0.5-0.5
Progressive ratio test 1 inactive lever presses1.31.92.91.31.01.41.31.4-1.21.21.2-1.41.51.21.21.71.71.7
Progressive ratio test 2 active lever presses0.60.71.1-0.7-1.0-0.8-0.9-0.80.9-0.9-0.90.7-0.6-1.0-1.0-0.9-0.4-0.4
Progressive ratio test 2 breakpoint0.50.61.0-0.7-1.0-0.7-0.8-0.70.8-0.8-0.80.6-0.5-1.0-1.0-0.9-0.4-0.4
Progressive ratio test 2 inactive lever presses0.10.10.6-0.3-0.8-0.2-0.3-0.20.5-0.5-0.50.00.1-0.3-0.30.10.40.4
Incentive Sensitization - Responses0.30.50.8-0.7-0.9-0.7-0.7-0.60.7-0.7-0.70.5-0.4-0.9-0.9-0.8-0.4-0.4
Incentive Sensitization - Breakpoint0.30.40.9-0.7-0.9-0.6-0.7-0.60.7-0.7-0.70.5-0.3-0.8-0.8-0.8-0.3-0.3
Sum of active levers in priming session hrs 5-61.00.92.01.21.41.01.11.0-1.11.11.1-0.90.70.80.80.80.50.5
Progressive ratio1.42.25.2-1.6-2.3-1.5-1.7-1.51.8-1.8-1.71.3-1.0-1.3-1.3-1.4-0.5-0.5
Food seeking constrained by brief footshock0.20.30.90.0-0.30.30.00.1-0.10.10.1-0.30.40.70.70.71.01.0
Seeking ratio, punishment vs. effort1.21.82.71.31.71.31.31.2-1.41.41.4-1.10.91.61.51.60.90.9
Retroperitoneal fat weight0.00.20.3-0.5-0.4-0.5-0.5-0.50.5-0.5-0.50.5-0.6-0.2-0.2-0.0-0.3-0.3
Reaction time number correct3.36.47.02.72.42.62.52.6-2.62.62.6-2.62.52.42.42.42.52.5
Reaction time mean minus median0.00.00.1-0.4-0.3-0.1-0.2-0.20.3-0.3-0.10.2-0.2-0.1-0.10.2-0.0-0.0
Reaction time mean minus median AUC0.00.00.1-0.3-0.3-0.0-0.1-0.10.2-0.2-0.10.1-0.10.20.20.20.20.2
Reaction time num false alarms1.72.42.71.51.51.61.61.6-1.51.51.6-1.51.51.51.51.51.61.6
Reaction time num false alarms AUC1.62.43.11.51.51.61.61.6-1.51.51.6-1.61.61.41.41.41.81.8
Reaction time trials correct on left3.36.47.02.72.42.62.52.6-2.62.62.6-2.62.52.42.42.42.52.5
Reaction time trials on left3.46.47.02.62.42.62.52.6-2.62.62.6-2.62.62.42.42.42.52.5
Reaction time mean1.72.64.1-1.9-2.0-1.6-1.8-1.71.8-1.8-1.71.6-1.4-1.6-1.6-1.2-1.0-1.0
Reaction time mean AUC1.01.52.6-1.5-1.6-1.2-1.4-1.31.4-1.4-1.31.2-1.0-1.2-1.3-0.9-0.7-0.7
Median of all reaction times1.82.54.4-1.8-2.1-1.5-1.7-1.71.8-1.8-1.71.5-1.3-1.6-1.6-1.2-0.9-0.9
Reaction time omissions0.20.31.30.2-0.10.50.40.4-0.30.30.3-0.60.70.30.20.61.11.1
Reaction time false alarm rate0.10.10.20.20.20.30.30.3-0.20.20.2-0.30.30.20.20.20.50.5
Reaction time premature initiation rate0.30.40.60.40.20.60.50.5-0.60.60.6-0.60.70.70.70.70.70.7
Reaction time premature initiations2.03.63.91.81.62.01.91.9-2.02.02.0-1.92.01.91.91.91.91.9
Std. dev. reaction times0.81.52.9-1.5-1.7-1.2-1.4-1.31.4-1.4-1.31.2-1.0-1.1-1.1-0.8-0.6-0.6
Reaction time trials completed3.46.47.02.62.42.62.52.6-2.62.62.6-2.62.62.42.42.42.52.5
Reaction time trials AUC3.56.77.32.72.42.72.62.6-2.72.72.7-2.62.62.42.42.42.62.6
Run reversals in cocaine runway, females1.41.41.9-1.4-1.4-1.2-1.3-1.31.3-1.3-1.31.2-1.2-0.9-1.1-1.0-1.0-1.0
Run reversals in cocaine runway, males0.10.10.2-0.3-0.4-0.1-0.3-0.10.1-0.1-0.10.00.1-0.4-0.4-0.3-0.0-0.0
Latency to leave start box in cocaine runway1.01.21.8-1.2-1.3-1.1-1.2-1.21.1-1.1-1.21.1-1.0-0.9-1.0-1.1-0.7-0.7
Latency to leave start box in cocaine runway, F0.60.71.1-0.8-0.8-0.8-0.8-0.80.8-0.8-0.90.8-0.8-0.9-1.0-1.1-0.9-0.9
Latency to leave start box in cocaine runway, M0.40.40.9-0.8-0.9-0.6-0.8-0.80.7-0.7-0.70.7-0.6-0.4-0.4-0.4-0.1-0.1
Std. dev. time between licks in bursts0.10.10.10.20.30.30.30.3-0.30.30.3-0.30.20.30.30.10.10.1
Total sessions with >9 infusions1.11.32.1-1.0-1.5-1.2-1.4-1.21.3-1.3-1.31.1-1.0-1.3-1.3-0.8-0.6-0.6
Short access day 1 total inactive lever presses0.00.00.1-0.2-0.3-0.1-0.2-0.10.3-0.3-0.30.1-0.00.00.00.40.20.2
Short access day 10 total inactive lever presses0.10.20.50.20.30.40.30.4-0.40.40.4-0.40.40.70.70.60.50.5
Short access day 1 total infusions0.10.20.6-0.3-0.8-0.4-0.5-0.40.5-0.5-0.50.3-0.1-0.5-0.5-0.00.10.1
Short access day 10 total infusions0.60.81.0-0.7-0.9-0.9-1.0-1.00.9-0.9-0.91.0-1.0-1.0-1.0-0.7-0.7-0.7
Short access total infusions1.21.52.3-1.1-1.5-1.3-1.4-1.31.3-1.3-1.31.2-1.0-1.5-1.5-1.1-0.7-0.7
Short access day 1 locomotion1.11.31.8-1.2-1.3-1.2-1.3-1.21.3-1.3-1.31.1-1.0-1.2-1.2-0.9-0.9-0.9
Short access day 10 total locomotion0.30.51.2-0.5-0.2-0.7-0.7-0.70.6-0.6-0.60.9-1.1-0.7-0.7-0.4-0.9-0.9
Short access total locomotion0.50.61.0-0.6-0.7-0.8-0.8-0.70.8-0.8-0.80.8-0.7-1.0-1.0-0.6-0.5-0.5
One hour access (0.3 mA shock)0.30.30.60.60.80.60.60.5-0.60.60.6-0.50.40.60.60.60.30.3
Compulsive drug intake1.41.73.21.41.81.31.51.4-1.41.41.4-1.21.11.31.31.20.80.8
One hour access (shock baseline)0.00.00.2-0.3-0.4-0.2-0.3-0.30.2-0.2-0.20.2-0.2-0.0-0.00.1-0.0-0.0
Social response proportion0.70.81.7-0.8-1.3-0.9-1.0-0.71.0-1.0-0.90.6-0.3-1.2-1.2-0.9-0.4-0.4
Social responses0.40.61.0-0.8-1.0-0.8-0.9-0.70.9-0.9-0.80.6-0.5-0.9-0.8-0.6-0.4-0.4
Social time0.20.31.1-0.3-1.10.1-0.3-0.10.2-0.2-0.2-0.20.6-0.2-0.20.51.01.0
Soleus weight1.95.710.52.83.22.42.82.5-2.62.62.6-2.21.92.32.31.91.51.5
Bone: stiffness0.71.11.61.21.01.11.11.1-1.01.01.0-1.21.21.11.10.81.01.0
Tibialis anterior weight0.93.03.81.82.01.81.91.7-1.91.91.9-1.61.51.81.81.61.41.4
Time to tail flick, vehicle, before self-admin1.11.22.41.01.01.01.01.0-1.01.00.9-0.90.91.51.41.31.01.0
Time to tail flick, vehicle, after self-admin0.00.00.20.20.50.10.20.2-0.20.20.2-0.0-0.10.1-0.0-0.0-0.1-0.1
Time to tail flick, test, before self-admin0.70.71.3-1.0-1.2-0.9-0.9-0.90.9-0.9-1.00.8-0.7-0.8-0.7-0.8-0.4-0.4
Time to tail flick, test, after self-admin1.81.92.51.51.61.41.61.5-1.61.61.5-1.41.41.11.11.30.80.8
Delta time to tail flick, vehicle, before/after SA0.20.20.50.40.70.40.50.4-0.50.50.5-0.30.20.10.10.2-0.0-0.0
Delta time to tail flick, test, before/after SA2.42.53.11.71.71.61.71.7-1.71.71.7-1.61.61.41.31.51.31.3
Tibia length0.10.30.60.50.50.50.40.6-0.40.40.4-0.60.60.40.40.60.80.8
Ambulatory time before self-admin0.50.81.2-0.7-0.6-0.9-0.8-0.90.8-0.8-0.70.9-1.0-1.1-1.1-1.1-1.0-1.0
Ambulatory time after self-admin0.10.10.2-0.2-0.3-0.2-0.3-0.30.3-0.3-0.20.2-0.2-0.4-0.2-0.4-0.0-0.0
Bone: tissue strength0.10.10.3-0.5-0.5-0.3-0.5-0.40.4-0.4-0.40.3-0.3-0.1-0.1-0.00.20.2
Total heroin consumption5.16.08.52.72.92.52.62.5-2.62.62.7-2.32.12.42.42.32.02.0
Bone: trabecular number0.40.71.20.70.70.90.70.7-0.90.90.9-0.70.71.11.10.70.80.8
Bone: trabecular spacing0.20.20.4-0.4-0.4-0.5-0.4-0.40.5-0.5-0.50.4-0.4-0.7-0.6-0.4-0.4-0.4
Bone: trabecular thickness0.00.00.0-0.00.10.1-0.00.0-0.10.10.00.0-0.10.10.00.10.10.1
Bone: trabecular tissue density0.00.10.1-0.1-0.1-0.2-0.2-0.20.2-0.2-0.20.3-0.3-0.3-0.3-0.1-0.3-0.3
Water consumed over 24 hours1.01.32.01.20.71.21.11.2-1.11.11.1-1.31.31.11.11.01.41.4
Number of responses in last shaping day0.00.00.2-0.2-0.4-0.2-0.3-0.30.2-0.2-0.20.2-0.2-0.3-0.30.0-0.0-0.0