Plcl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb intron excision ratio chr9_57180640_57184146 0.62 0.03 3.2e-03 -0.01 -0.01 -0 -0.01 7.6e-01 4.8e-01 4.5e-01 7.3e-01
2 LHb intron excision ratio chr9_57184349_57195930 0.67 0 3.1e-04 -0.01 -0.01 -0 -0.01 7.6e-01 5.1e-01 4.4e-01 8.5e-01
3 PL gene expression Plcl1 0.03 0.02 2.2e-03 0 0 0 0 2.6e-01 1.7e-01 2.5e-01 3.4e-01
4 Eye gene expression Plcl1 0.52 0.19 1.7e-04 0.13 0.17 0.06 0.18 4.4e-03 1.6e-03 3.8e-02 1.1e-03
5 Brain mRNA stability Plcl1 0.05 0.03 8.5e-05 0.02 0.03 0 0.02 3.0e-03 1.2e-03 1.6e-01 4.3e-03
6 Adipose gene expression Plcl1 0.03 0.02 4.4e-04 0.03 0.03 0.02 0.02 7.7e-04 6.9e-04 1.3e-03 1.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density4.37.212.10.4-0.72.83.33.5-3.5
Area under the delay curve0.30.30.9-0.90.9-0.40.10.2-0.2
BMI with tail2.06.48.2-1.92.2-2.9-2.7-2.72.7
BMI without tail0.20.41.11.1-0.90.5-0.1-0.40.3
Body weight0.83.56.51.4-1.42.62.11.7-1.8
Weight adjusted by age0.60.71.2-0.70.60.51.11.0-1.0
Bone surface4.17.311.80.6-0.92.83.33.4-3.4
Bone volume4.27.112.40.3-0.62.63.33.5-3.5
Breakpoint value in progressive ratio session0.10.10.10.3-0.3-0.3-0.2-0.10.1
Number of licking bursts0.70.81.6-1.21.3-0.9-0.5-0.40.4
Context. condit. distance diff. score0.70.81.70.6-0.5-0.4-1.0-1.31.2
Locomotion velocity, session 10.50.51.0-0.50.5-1.0-0.8-0.70.7
Locomotion distance, session 10.00.10.10.00.0-0.2-0.3-0.40.3
Locomotion velocity, session 20.40.40.8-0.90.8-0.8-0.5-0.30.4
Locomotion distance, session 20.10.10.4-0.60.6-0.1-0.0-0.20.2
Locomotion velocity, session 30.50.51.21.1-1.10.80.2-0.20.2
Locomotion distance, session 30.00.10.10.2-0.20.1-0.2-0.30.3
Stereotopy head waving bouts, day 31.31.52.41.0-0.9-0.7-1.4-1.61.5
Stereotopy head waving duration, day 30.40.51.21.1-1.00.4-0.3-0.60.6
Locomotion velocity, session 70.30.30.6-0.70.7-0.8-0.3-0.20.2
Locomotion distance, session 70.10.10.2-0.40.4-0.4-0.2-0.10.1
Stereotopy head waving bouts, day 70.50.50.9-0.40.40.61.00.8-0.9
Stereotopy head waving duration, day 70.30.40.8-0.20.30.80.90.6-0.6
Locomotion velocity, session 81.41.64.6-2.12.1-0.80.20.2-0.2
Locomotion distance, session 80.40.61.4-0.00.1-0.5-0.9-1.21.1
Degree of sensitization distance0.40.40.9-0.90.9-0.30.30.5-0.4
Degree of sensitization stereotypy1.41.51.9-1.41.40.61.41.2-1.3
Conditioned locomotion0.50.61.0-0.20.00.91.01.0-1.0
Cocaine response after cond. corrected2.02.33.5-1.71.50.11.41.9-1.8
Cocaine response after cond. not corrected2.73.05.3-1.51.20.61.92.3-2.2
Cocaine response before conditioning0.10.10.30.5-0.40.30.0-0.10.1
Saline control response0.10.10.20.10.10.4-0.0-0.40.4
Bone: connectivity density2.74.37.3-0.20.02.02.72.7-2.7
Bone: cortical apparent density5.57.211.3-0.81.0-3.2-3.4-3.13.2
Bone: cortical area0.10.10.50.6-0.70.1-0.00.2-0.1
Bone: cortical porosity3.13.45.22.1-2.32.01.41.5-1.5
Bone: cortical porosity4.04.45.72.1-2.32.41.92.0-2.0
Bone: cortical thickness1.32.13.8-0.10.1-1.7-1.9-1.71.8
Bone: cortical thickness1.72.03.5-1.71.7-1.9-1.1-0.80.9
Bone: cortical tissue density5.47.110.9-0.91.1-3.2-3.3-3.13.1
Condit. Reinf. active minus inactive responses0.30.30.7-0.80.8-0.60.00.4-0.3
Condit. Reinf. active-inactive response ratio0.20.30.6-0.80.7-0.40.10.4-0.3
Condit. Reinf. active responses0.50.61.0-1.00.8-0.20.61.0-0.9
Condit. Reinf. inactive responses0.20.20.4-0.60.5-0.10.30.5-0.4
Incentive salience index mean0.60.81.7-1.31.2-0.70.20.7-0.6
Condit. Reinf. lever presses0.10.20.4-0.40.2-0.20.30.7-0.6
Condit. Reinf. active minus inactive responses1.51.94.2-0.70.40.51.62.0-1.9
Condit. Reinf. active-inactive response ratio0.50.50.8-0.80.7-0.60.30.9-0.8
Condit. Reinf. active responses0.91.32.5-1.20.9-0.01.11.6-1.5
Condit. Reinf. inactive responses0.20.20.3-0.60.40.00.40.6-0.5
Condit. Reinf. lever presses1.21.63.3-1.81.7-1.8-0.6-0.10.2
Condit. Reinf. lever reinforcers received1.11.52.5-1.41.1-0.31.01.6-1.5
Conditioned reinforcement - actives0.50.51.21.1-1.00.7-0.0-0.10.0
Conditioned reinforcement - inactives0.30.30.90.9-0.90.3-0.10.1-0.1
Conditioned locomotion0.30.40.6-0.80.8-0.6-0.5-0.50.5
Patch foraging indifference point 0 sec1.93.07.6-2.82.7-1.7-0.3-0.00.1
Patch foraging indifference point AUC0.10.10.1-0.10.00.30.30.3-0.3
Delay disc. indifference point, 0s delay1.01.12.0-1.31.4-1.1-0.7-0.80.7
Delay disc. indifference point, 16s delay0.10.10.4-0.60.6-0.30.00.3-0.2
Delay disc. indifference point, 2s delay2.12.36.0-2.42.5-1.3-0.1-0.10.1
Delay disc. indifference point, 24s delay0.20.20.40.3-0.2-0.4-0.6-0.60.6
Delay disc. indifference point, 4s delay0.60.61.4-1.11.2-0.8-0.4-0.40.4
Delay disc. indifference point, 8s delay0.40.40.7-0.1-0.00.70.90.9-0.9
Indifference point function ln k1.72.45.8-2.42.4-1.5-0.5-0.40.4
Indifference point function log k1.72.45.8-2.42.4-1.5-0.5-0.40.4
Patch foraging total patch changes 0 sec1.82.97.0-2.62.6-1.8-0.5-0.20.3
Patch foraging total patch changes 12 sec1.11.53.8-1.91.9-1.2-0.3-0.10.2
Patch foraging total patch changes 18 sec1.31.73.1-1.31.3-1.8-1.3-1.01.1
Patch foraging total patch changes 24 sec0.00.10.1-0.30.30.10.30.2-0.2
Patch foraging total patch changes 6 sec1.52.36.4-2.52.5-0.60.50.4-0.4
Patch foraging time to switch 0 sec1.32.05.72.4-2.30.8-0.2-0.30.3
Patch foraging water rate 0 sec0.30.51.0-1.00.90.20.60.5-0.6
Patch foraging water rate 12 sec2.94.412.5-3.53.5-1.10.50.6-0.5
Patch foraging water rate 18 sec0.50.71.6-1.31.2-0.20.60.7-0.6
Patch foraging water rate 24 sec0.40.51.1-0.10.21.11.00.6-0.7
Patch foraging water rate 6 sec0.20.30.9-0.90.9-0.10.10.0-0.0
Seeking ratio, delayed vs. immediate footshock1.82.03.7-1.10.91.41.91.5-1.5
Distance traveled before self-admin1.61.72.8-0.50.41.21.61.7-1.7
Distance traveled after self-admin0.91.02.6-1.61.6-0.7-0.2-0.30.3
Extensor digitorum longus weight1.04.07.80.6-0.3-1.4-2.4-2.82.7
Bone: elastic displacement0.80.92.1-1.41.4-1.0-0.4-0.30.3
Bone: elastic work0.50.61.2-0.1-0.00.50.91.1-1.1
Bone: endosteal estimation2.65.78.80.9-1.22.52.93.0-2.9
Bone: endosteal perimeter2.75.68.30.9-1.22.62.92.9-2.9
Epididymis fat weight1.33.15.12.0-2.12.31.51.2-1.2
Delta time in closed arm before/after self-admin1.21.23.01.7-1.60.1-0.8-0.70.7
Delta time in open arm before/after self-admin4.24.06.1-1.61.31.42.42.5-2.4
Diff in mean of infusions in LGA sessions1.01.12.2-1.51.40.20.90.8-0.8
Delay discount exponential model param0.30.41.01.0-0.90.4-0.2-0.30.3
Extinction: sum of active levers before priming0.70.71.5-0.20.11.01.20.9-1.0
Active lever presses in extinction session 60.10.10.2-0.50.3-0.10.40.4-0.4
Bone: final force1.32.14.42.0-2.11.50.70.7-0.7
Bone: final moment1.11.84.22.0-2.01.40.50.4-0.5
Food consumed during 24 hour testing period0.20.20.70.8-0.80.2-0.2-0.10.1
Glucose0.71.11.71.2-1.10.4-0.8-1.31.2
Heart weight0.50.82.2-1.51.4-0.40.20.3-0.2
Delay discount hyperbolic model param0.40.41.21.1-1.10.5-0.1-0.10.1
Intermittent access intake day 1-15 change0.20.20.50.3-0.2-0.1-0.5-0.70.6
Intermittent access intake escalation0.20.20.40.4-0.2-0.2-0.5-0.60.6
Intermittent access intake escalation 20.20.20.3-0.30.30.50.60.3-0.3
Intermitt. access day 1 inactive lever presses1.31.41.81.3-1.1-0.5-1.3-1.31.2
Intermitt. access day 15 inactive lever presses0.10.10.30.5-0.5-0.1-0.2-0.30.2
Intermitt. access escalation Index2.32.15.92.4-2.30.9-0.2-0.30.2
Intermittent access day 1 total infusions1.01.13.41.8-1.80.60.00.2-0.2
Intermittent access day 15 total infusions1.11.33.71.9-1.80.4-0.4-0.40.3
Intermittent access terminal intake (last 3 days)0.60.71.81.3-1.30.1-0.4-0.40.4
Intermittent access total infusions1.31.54.22.0-2.10.5-0.2-0.00.0
Intermittent access day 1 locomotion0.70.81.71.3-1.3-0.4-0.9-0.40.5
Intermittent access day 15 total locomotion0.70.72.21.4-1.50.20.00.3-0.3
Intermittent access total locomotion0.91.03.01.7-1.70.1-0.4-0.10.1
Intermittent access standard deviation1.01.11.81.3-1.2-0.4-1.1-1.01.0
Left kidney weight0.10.40.6-0.40.40.50.80.8-0.8
Right kidney weight0.41.01.7-0.90.90.61.31.1-1.1
Cocaine induced anxiety0.10.10.2-0.50.5-0.2-0.1-0.30.3
Post-drug Anxiety0.60.72.0-1.41.4-0.30.20.2-0.2
Baseline Anxiety0.10.10.3-0.20.10.10.30.6-0.5
Tail length7.823.634.94.9-5.15.94.54.2-4.3
Length with tail7.527.541.94.2-4.56.55.65.2-5.3
Length without tail0.71.62.40.3-0.51.41.61.5-1.5
Times rat made contact with spout0.30.30.80.9-0.90.3-0.3-0.30.3
Lifetime Intake1.11.33.61.9-1.90.4-0.4-0.30.3
Liver weight, left1.42.23.6-0.50.31.51.91.8-1.8
Liver weight, right1.32.13.70.1-0.11.71.91.7-1.8
Locomotor activity0.00.00.10.3-0.40.0-0.1-0.00.0
Locomotor testing distance0.30.61.6-1.31.2-0.7-0.1-0.00.1
Locomotor testing rearing0.10.10.30.1-0.20.60.50.3-0.4
Locomotion in novel chamber1.01.22.1-0.30.4-1.4-1.3-1.31.3
Locomotion in novel chamber post-restriction1.11.32.20.7-0.5-1.1-1.5-1.31.4
Fecal boli incidents, locomotor time 12.02.23.9-0.90.70.91.82.0-1.9
Change in fecal boli incidents, locomotor task0.20.10.3-0.00.0-0.3-0.5-0.50.5
Time >=10cm from walls, locomotor time 12.42.46.2-2.52.3-0.80.71.0-0.9
Bouts of movement, locomotor time 10.20.20.4-0.60.5-0.6-0.20.00.1
Total resting periods, locomotor time 10.91.02.1-1.11.0-1.5-0.9-0.60.7
Rest time, locomotor task time 11.11.22.20.5-0.6-1.1-1.5-1.31.3
Distance moved, locomotor task time 11.51.72.5-1.61.50.61.41.2-1.2
Vertical activity count, locomotor time 10.10.10.4-0.20.30.60.50.0-0.1
Time >=10cm from walls, locomotor time 22.83.06.2-2.52.2-0.21.31.6-1.6
Bouts of movement, locomotor time 22.83.08.3-2.92.8-1.3-0.1-0.10.2
Total resting periods, locomotor time 22.62.87.2-2.72.6-1.5-0.4-0.30.4
Rest time, locomotor task time 21.31.51.81.3-1.4-0.6-1.3-1.21.2
Distance moved, locomotor task time 21.61.93.3-1.81.70.31.31.3-1.3
Vertical activity count, locomotor time 20.70.82.3-1.51.5-0.10.50.2-0.2
Light reinforcement 11.32.34.1-0.30.4-1.5-1.8-2.02.0
Light reinforcement 20.50.71.8-1.31.3-0.60.10.2-0.2
Bone: marrow area2.45.38.20.9-1.12.42.82.9-2.8
Bone: maximum diameter0.30.60.90.7-0.90.60.71.0-0.9
Bone: maximum force1.73.04.41.7-1.82.11.61.5-1.6
Bone: maximum moment1.42.33.51.6-1.71.91.31.2-1.3
Mean time between licks in bursts0.60.81.01.0-1.00.1-0.9-1.01.0
Mean num. licks in bursts0.60.71.91.3-1.40.70.00.0-0.0
Cd content in liver1.21.33.31.8-1.71.20.2-0.0-0.0
Co content in liver0.91.11.51.0-0.9-0.6-1.2-1.21.2
Cu content in liver0.10.10.3-0.50.5-0.20.20.3-0.3
Fe content in liver0.81.01.60.2-0.31.01.21.3-1.2
K content in liver0.10.10.2-0.50.50.00.20.2-0.2
Mg content in liver0.60.60.9-0.70.70.60.90.8-0.8
Mn content in liver1.21.42.3-0.20.3-1.3-1.5-1.41.5
Na content in liver0.70.81.3-0.80.70.20.91.2-1.1
Rb content in liver1.92.43.3-1.81.70.41.61.7-1.6
Se content in liver0.10.10.2-0.40.4-0.3-0.2-0.10.2
Sr content in liver4.33.99.93.1-3.10.5-1.2-1.21.1
Zn content in liver0.10.10.30.5-0.50.2-0.1-0.10.1
Bone: minimum diameter0.30.50.80.7-0.90.60.60.8-0.7
Time in familiar zone, hab. session 10.50.41.11.0-0.90.80.20.0-0.1
Time in novel zone, hab. session 10.50.51.4-1.21.1-0.7-0.2-0.00.1
Total zone transitions, hab. session 10.40.51.3-1.21.1-0.40.30.4-0.4
Total locomotion distance, hab. session 10.50.71.5-1.21.2-0.50.40.7-0.6
Locomotion velocity, hab. session 10.10.20.4-0.30.30.10.50.6-0.6
Time in familiar zone, hab. session 21.01.11.8-0.50.6-1.4-1.2-1.11.1
Time in novel zone, hab. session 20.40.40.60.5-0.60.80.70.5-0.5
Total zone transitions, hab. session 20.30.41.01.0-0.90.70.3-0.0-0.0
Total locomotion distance, hab. session 20.50.61.21.1-1.11.00.50.3-0.3
Locomotion velocity, hab. session 20.71.01.91.4-1.41.20.70.4-0.5
Novel to familiar place preference ratio0.90.91.6-0.0-0.11.01.21.2-1.2
Novelty place preference0.91.01.70.1-0.21.11.31.2-1.2
Time in novel zone, NPP test0.80.81.4-0.1-0.00.91.21.1-1.1
Total zone transitions, NPP test0.10.10.2-0.10.2-0.4-0.4-0.50.5
Total locomotion distance, NPP test0.30.40.7-0.80.8-0.8-0.4-0.40.4
Locomotion velocity, NPP test0.20.30.5-0.40.4-0.7-0.6-0.60.6
Intraocular pressure2.23.04.5-0.60.7-2.1-2.1-2.12.1
Delta distance traveled before/after self-admin1.51.62.0-1.11.2-1.2-1.2-1.41.4
Delta ambulatory time before/after self-admin1.41.62.2-0.90.9-1.2-1.4-1.51.5
Parametrial fat weight0.00.00.10.4-0.40.0-0.0-0.10.1
Pavlov. Cond. lever latency0.60.81.61.3-1.10.4-0.6-0.90.8
Pavlov. Cond. magazine entry latency0.50.71.6-1.31.2-0.70.20.6-0.5
Pavlov. Cond. change in total contacts1.71.84.5-2.12.0-1.20.10.5-0.4
Pavlov. Cond. index score0.30.40.8-0.90.8-0.60.20.6-0.5
Pavlov. Cond. latency score0.50.71.3-1.11.0-0.40.50.9-0.8
Pavlov. Cond. lever contacts0.30.40.8-0.90.8-0.50.20.6-0.5
Pavlov. Cond. magazine entry number0.50.61.11.1-0.90.4-0.5-0.80.7
Pavlov. Cond. intertrial magazine entries0.80.91.80.6-0.61.31.10.9-1.0
Pavlov. Cond. lever-magazine prob. diff.0.30.40.8-0.90.8-0.9-0.10.4-0.3
Pavlov. Cond. response bias0.10.20.3-0.50.4-0.50.10.4-0.4
Pavlov. Cond. lever latency0.91.23.31.1-1.01.81.00.4-0.5
Pavlov. Cond. magazine entry latency0.20.20.30.6-0.6-0.4-0.4-0.30.3
Pavlov. Cond. change in total contacts1.01.43.3-1.61.5-1.8-0.60.10.1
Pavlov. Cond. index score0.50.72.4-0.70.6-1.5-0.8-0.30.4
Pavlov. Cond. latency score0.40.51.9-0.60.5-1.4-0.7-0.30.4
Pavlov. Cond. lever contacts0.91.33.3-1.51.3-1.8-0.7-0.00.2
Pavlov. Cond. magazine entry number0.10.10.1-0.30.40.2-0.1-0.30.2
Pavlov. Cond. intertrial magazine entries0.30.41.3-1.11.2-0.20.1-0.00.0
Pavlov. Cond. lever-magazine prob. diff.0.60.72.4-0.80.7-1.6-0.8-0.30.4
Pavlov. Cond. response bias0.30.41.3-0.70.6-1.1-0.20.3-0.2
Time in closed arm before self-admin2.12.44.40.2-0.41.51.82.1-2.1
Time in closed arm after self-admin0.70.71.2-0.80.70.30.91.1-1.0
Time in open arm before self-admin4.24.67.91.5-1.1-1.4-2.6-2.82.7
Time in open arm after self-admin0.20.20.3-0.1-0.00.50.60.5-0.5
Bone: periosteal estimation1.42.84.11.1-1.31.71.82.0-2.0
Bone: periosteal perimeter1.01.72.60.6-0.81.31.51.6-1.6
Bone: post-yield work1.01.42.51.2-1.21.61.10.9-1.0
Progressive ratio test 1 active lever presses2.72.98.02.8-2.70.2-0.9-0.70.6
Progressive ratio test 1 breakpoint2.12.26.12.5-2.40.2-0.7-0.50.5
Progressive ratio test 1 inactive lever presses7.98.720.34.5-4.10.1-2.3-2.22.1
Progressive ratio test 2 active lever presses3.23.410.03.2-3.10.7-0.5-0.30.3
Progressive ratio test 2 breakpoint2.32.66.92.6-2.50.1-1.0-0.70.7
Progressive ratio test 2 inactive lever presses1.92.25.42.3-2.2-0.1-1.1-0.90.9
Incentive Sensitization - Responses1.31.33.51.9-1.90.90.20.2-0.2
Incentive Sensitization - Breakpoint1.21.23.21.8-1.80.90.20.2-0.2
Sum of active levers in priming session hrs 5-60.70.61.1-0.1-0.00.71.11.1-1.1
Progressive ratio0.80.91.40.9-0.8-0.5-1.2-1.11.1
Food seeking constrained by brief footshock0.10.20.50.2-0.20.70.50.3-0.4
Seeking ratio, punishment vs. effort1.41.73.2-0.50.51.41.81.5-1.5
Retroperitoneal fat weight0.10.20.50.7-0.60.60.3-0.20.1
Reaction time number correct0.50.71.7-1.21.3-0.8-0.2-0.30.3
Reaction time mean minus median1.92.67.32.7-2.70.9-0.2-0.10.1
Reaction time mean minus median AUC0.81.03.01.7-1.70.5-0.2-0.00.0
Reaction time num false alarms1.72.33.7-0.60.7-1.5-1.8-1.91.9
Reaction time num false alarms AUC1.82.44.4-0.40.6-1.4-1.9-2.12.0
Reaction time trials correct on left0.50.71.7-1.21.3-0.8-0.2-0.30.3
Reaction time trials on left0.40.61.4-1.11.2-0.7-0.2-0.30.3
Reaction time mean2.63.710.33.1-3.21.40.20.4-0.4
Reaction time mean AUC2.83.810.93.2-3.31.2-0.10.1-0.1
Median of all reaction times2.12.98.32.7-2.91.20.20.5-0.5
Reaction time omissions0.50.71.91.3-1.40.80.10.1-0.2
Reaction time false alarm rate0.91.32.40.2-0.1-0.8-1.4-1.61.5
Reaction time premature initiation rate3.64.98.7-2.93.0-2.8-1.4-0.91.0
Reaction time premature initiations4.36.111.5-3.33.4-3.0-1.4-1.11.2
Std. dev. reaction times1.52.14.92.1-2.21.40.60.7-0.7
Reaction time trials completed0.40.61.4-1.11.2-0.7-0.2-0.30.3
Reaction time trials AUC0.30.51.1-1.01.0-0.7-0.3-0.40.4
Run reversals in cocaine runway, females0.30.30.80.9-0.90.50.1-0.10.0
Run reversals in cocaine runway, males1.31.32.9-1.71.6-1.3-0.4-0.20.3
Latency to leave start box in cocaine runway3.53.75.8-0.20.4-2.2-2.4-2.42.4
Latency to leave start box in cocaine runway, F2.83.05.10.4-0.2-1.8-2.2-2.32.2
Latency to leave start box in cocaine runway, M0.90.81.5-0.80.9-1.2-0.9-0.70.8
Std. dev. time between licks in bursts2.32.84.2-0.91.0-1.6-1.9-2.12.0
Total sessions with >9 infusions2.32.64.52.1-2.0-0.5-1.6-1.51.4
Short access day 1 total inactive lever presses0.80.92.3-1.51.5-0.6-0.3-0.20.2
Short access day 10 total inactive lever presses0.00.00.10.1-0.0-0.1-0.3-0.20.2
Short access day 1 total infusions0.70.71.01.0-0.9-0.3-1.0-0.90.8
Short access day 10 total infusions0.10.10.20.4-0.50.40.20.3-0.3
Short access total infusions0.60.71.21.1-1.0-0.3-0.9-0.70.7
Short access day 1 locomotion2.02.14.82.2-2.1-0.2-1.2-1.01.0
Short access day 10 total locomotion0.30.30.7-0.80.8-0.7-0.2-0.00.1
Short access total locomotion0.70.71.91.4-1.40.60.00.0-0.1
One hour access (0.3 mA shock)0.60.71.81.3-1.3-0.4-0.6-0.30.4
Compulsive drug intake0.10.10.20.1-0.0-0.4-0.4-0.30.4
One hour access (shock baseline)0.30.41.00.9-1.00.40.20.3-0.3
Social response proportion2.62.85.0-0.40.21.82.22.0-2.0
Social responses0.81.02.20.9-0.91.51.00.7-0.8
Social time0.30.40.91.0-1.00.70.20.0-0.1
Soleus weight0.10.40.7-0.50.40.40.70.8-0.8
Bone: stiffness2.74.37.72.1-2.22.81.91.6-1.7
Tibialis anterior weight0.31.22.10.6-0.4-0.9-1.3-1.41.4
Time to tail flick, vehicle, before self-admin0.50.51.51.2-1.20.1-0.4-0.30.3
Time to tail flick, vehicle, after self-admin0.10.10.10.4-0.40.30.10.2-0.2
Time to tail flick, test, before self-admin1.01.01.5-1.21.2-1.2-0.8-0.60.7
Time to tail flick, test, after self-admin1.01.01.71.3-1.1-0.1-1.0-1.11.0
Delta time to tail flick, vehicle, before/after SA0.00.00.00.1-0.00.10.0-0.00.0
Delta time to tail flick, test, before/after SA1.41.23.21.8-1.60.0-0.7-0.80.7
Tibia length4.011.316.43.2-3.54.03.23.1-3.1
Ambulatory time before self-admin1.51.52.4-1.00.91.01.61.4-1.4
Ambulatory time after self-admin2.42.76.7-2.62.6-1.2-0.6-0.80.8
Bone: tissue strength2.02.04.02.0-1.91.80.70.3-0.4
Total heroin consumption0.10.10.10.4-0.40.20.10.1-0.1
Bone: trabecular number3.35.28.20.4-0.62.52.92.8-2.8
Bone: trabecular spacing0.30.40.8-0.20.2-0.8-0.9-0.70.7
Bone: trabecular thickness1.31.52.9-0.40.21.01.61.7-1.7
Bone: trabecular tissue density1.92.63.81.9-1.9-0.7-1.8-1.51.5
Water consumed over 24 hours0.60.81.2-0.80.8-1.1-0.9-0.80.8
Number of responses in last shaping day2.93.07.42.7-2.50.2-1.1-1.31.2