Hub : Genes

Plcl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Plcl1	0.03	0.02	2.0e-03	0.01	0.02	0.01	0.01	1.2e-02	6.0e-03	1.1e-02	1.1e-02
2	Brain	mRNA stability	Plcl1	0.04	0.03	1.0e-04	0.02	0.03	0.02	0.02	1.2e-02	1.6e-03	5.9e-03	2.8e-03
3	Adipose	gene expression	Plcl1	0.03	0.02	1.7e-04	0.03	0.03	0.03	0.03	2.8e-04	1.7e-04	2.6e-04	2.8e-04
4	NAcc	gene expression	Plcl1	0.02	0.01	8.9e-03	0	0.01	0	0	1.1e-01	1.9e-02	1.1e-01	5.7e-02
5	Eye	gene expression	Plcl1	0.53	0.2	4.8e-04	0.17	0.15	0.11	0.15	1.5e-03	3.0e-03	8.8e-03	2.9e-03
6	Adipose	mRNA stability	Plcl1	0.03	0.02	6.6e-03	0	0.01	0.01	0	3.5e-01	3.5e-02	6.3e-02	1.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	4.6	7.9	12.6	2.7	3.6	-3.5	2.0	2.4	-2.4
Area under the delay curve	0.2	0.2	0.5	-0.6	-0.0	-0.1	-0.7	0.2	-0.7
BMI with tail	2.2	7.7	12.8	-3.0	-3.6	3.4	-2.3	-1.7	2.1
BMI without tail	0.2	0.5	1.6	-0.1	-0.8	0.9	0.3	0.2	1.2
Body weight	1.1	4.8	8.4	2.9	2.1	-1.8	2.9	2.0	0.1
Weight adjusted by age	0.7	1.1	1.8	0.6	1.3	-1.3	0.2	1.0	-1.3
Bone surface	4.0	7.3	11.6	2.6	3.4	-3.3	2.0	2.3	-2.2
Bone volume	4.1	7.3	12.1	2.4	3.5	-3.5	1.6	2.1	-2.6
Breakpoint value in progressive ratio session	0.1	0.1	0.4	-0.2	0.2	-0.3	-0.4	-0.3	-0.6
Number of licking bursts	0.3	0.4	1.0	-1.0	-0.6	0.4	-1.0	-0.1	-0.3
Context. condit. distance diff. score	0.8	0.9	2.1	-0.3	-1.2	1.3	0.0	-0.4	1.5
Locomotion velocity, session 1	0.5	0.6	0.9	-0.9	-0.7	0.7	-0.9	-0.8	0.0
Locomotion distance, session 1	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.1	-0.1	0.3
Locomotion velocity, session 2	0.4	0.4	0.9	-0.9	-0.5	0.4	-0.9	-0.7	-0.3
Locomotion distance, session 2	0.0	0.0	0.1	-0.1	-0.2	0.2	0.0	0.2	0.3
Locomotion velocity, session 3	0.5	0.6	1.4	0.9	-0.0	0.2	1.2	0.4	1.1
Locomotion distance, session 3	0.1	0.1	0.2	0.1	-0.2	0.3	0.2	-0.1	0.5
Stereotopy head waving bouts, day 3	1.3	1.5	2.7	-0.5	-1.4	1.6	-0.1	-1.2	1.6
Stereotopy head waving duration, day 3	0.4	0.5	1.5	0.5	-0.4	0.6	0.8	-0.0	1.2
Locomotion velocity, session 7	0.3	0.3	0.8	-0.8	-0.2	0.1	-0.9	-0.3	-0.5
Locomotion distance, session 7	0.1	0.1	0.2	-0.3	-0.1	0.0	-0.4	-0.3	-0.3
Stereotopy head waving bouts, day 7	0.3	0.4	0.9	0.1	0.6	-0.6	0.0	1.0	-0.7
Stereotopy head waving duration, day 7	0.6	0.7	1.8	0.8	0.7	-0.6	0.9	1.3	-0.1
Locomotion velocity, session 8	0.5	0.6	1.2	-0.9	-0.0	-0.2	-1.1	0.5	-1.1
Locomotion distance, session 8	0.5	0.7	1.4	-0.5	-1.1	1.2	-0.1	-0.4	1.2
Degree of sensitization distance	0.3	0.3	1.0	-0.3	0.4	-0.5	-0.6	0.2	-1.0
Degree of sensitization stereotypy	1.3	1.4	3.6	0.5	1.1	-1.2	0.3	1.9	-1.2
Conditioned locomotion	0.6	0.7	1.0	0.8	1.0	-1.0	0.7	1.0	-0.6
Cocaine response after cond. corrected	1.9	2.3	6.6	-0.1	1.6	-1.8	-0.7	0.9	-2.6
Cocaine response after cond. not corrected	2.7	3.2	7.7	0.4	2.1	-2.3	-0.3	1.3	-2.8
Cocaine response before conditioning	0.1	0.1	0.2	0.3	-0.0	0.1	0.5	0.3	0.5
Saline control response	0.3	0.4	0.8	0.5	-0.2	0.3	0.8	0.8	0.9
Bone: connectivity density	3.0	4.6	7.1	1.8	2.6	-2.7	1.3	2.2	-2.0
Bone: cortical apparent density	5.3	7.3	10.2	-3.0	-3.2	3.0	-2.5	-2.6	1.5
Bone: cortical area	0.0	0.1	0.2	0.2	0.2	-0.1	0.1	-0.5	-0.1
Bone: cortical porosity	1.7	1.8	3.4	1.8	1.6	-1.4	1.6	0.3	-0.4
Bone: cortical porosity	3.1	3.4	5.9	2.4	2.2	-2.0	2.1	0.8	-0.6
Bone: cortical thickness	1.4	2.3	3.5	-1.4	-1.7	1.7	-1.2	-1.9	1.0
Bone: cortical thickness	1.8	2.1	4.9	-2.1	-1.2	0.9	-2.2	-1.0	-0.6
Bone: cortical tissue density	5.2	7.1	10.1	-2.9	-3.2	3.0	-2.5	-2.5	1.5
Condit. Reinf. active minus inactive responses	0.5	0.6	1.4	-0.7	0.2	-0.4	-1.0	-0.4	-1.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.0	-0.5	0.2	-0.4	-0.8	-0.1	-1.0
Condit. Reinf. active responses	0.6	0.8	2.6	-0.4	0.7	-0.9	-0.8	0.1	-1.6
Condit. Reinf. inactive responses	0.2	0.2	0.6	-0.1	0.4	-0.5	-0.3	0.2	-0.8
Incentive salience index mean	0.9	1.1	3.1	-0.9	0.4	-0.7	-1.3	-0.4	-1.8
Condit. Reinf. lever presses	0.3	0.4	1.3	-0.4	0.4	-0.5	-0.7	-0.4	-1.1
Condit. Reinf. active minus inactive responses	1.8	2.4	6.3	0.3	1.8	-2.0	-0.4	0.6	-2.5
Condit. Reinf. active-inactive response ratio	1.0	1.2	3.6	-0.7	0.6	-0.9	-1.3	-0.3	-1.9
Condit. Reinf. active responses	1.3	1.8	5.8	-0.3	1.3	-1.5	-0.9	0.1	-2.4
Condit. Reinf. inactive responses	0.2	0.2	0.7	-0.0	0.5	-0.6	-0.3	0.1	-0.8
Condit. Reinf. lever presses	1.7	2.3	5.7	-2.0	-0.6	0.3	-2.4	-1.3	-1.5
Condit. Reinf. lever reinforcers received	1.4	2.0	6.5	-0.5	1.2	-1.5	-1.2	0.0	-2.6
Conditioned reinforcement - actives	0.2	0.3	0.9	0.4	-0.3	0.5	0.6	-0.5	0.9
Conditioned reinforcement - inactives	0.2	0.3	1.6	0.1	-0.1	0.1	0.0	-1.2	0.2
Conditioned locomotion	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.2	-0.1	0.3
Patch foraging indifference point 0 sec	0.9	1.7	4.4	-1.8	-0.3	-0.0	-2.1	-0.1	-1.6
Patch foraging indifference point AUC	0.1	0.1	0.1	0.3	0.4	-0.4	0.2	0.1	-0.3
Delay disc. indifference point, 0s delay	0.7	0.8	1.6	-1.3	-1.0	0.9	-1.1	0.1	0.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	-0.4	0.1	-0.2	-0.6	-0.0	-0.7
Delay disc. indifference point, 2s delay	1.0	1.1	2.7	-1.5	-0.4	0.1	-1.6	0.7	-1.1
Delay disc. indifference point, 24s delay	0.2	0.3	0.4	-0.4	-0.6	0.6	-0.2	-0.6	0.5
Delay disc. indifference point, 4s delay	0.4	0.4	1.0	-1.0	-0.6	0.4	-0.9	0.0	-0.2
Delay disc. indifference point, 8s delay	0.4	0.5	0.7	0.6	0.8	-0.9	0.4	0.8	-0.7
Indifference point function ln k	0.7	1.1	2.9	-1.6	-0.6	0.3	-1.7	0.1	-0.9
Indifference point function log k	0.7	1.1	2.9	-1.6	-0.6	0.3	-1.7	0.1	-0.9
Patch foraging total patch changes 0 sec	0.9	1.7	4.5	-1.9	-0.5	0.2	-2.1	-0.2	-1.4
Patch foraging total patch changes 12 sec	0.6	0.7	1.9	-1.2	-0.3	0.1	-1.4	-0.3	-0.9
Patch foraging total patch changes 18 sec	1.0	1.5	2.8	-1.7	-1.2	1.0	-1.7	-1.1	-0.1
Patch foraging total patch changes 24 sec	0.0	0.1	0.1	0.2	0.3	-0.3	0.2	0.3	-0.2
Patch foraging total patch changes 6 sec	0.4	0.6	1.3	-0.7	0.2	-0.4	-0.8	1.1	-1.1
Patch foraging time to switch 0 sec	0.4	0.7	1.7	1.0	-0.1	0.3	1.2	-0.3	1.3
Patch foraging water rate 0 sec	0.2	0.4	0.9	0.2	0.6	-0.7	0.1	0.9	-0.7
Patch foraging water rate 12 sec	0.7	1.5	3.3	-1.3	0.2	-0.6	-1.5	1.2	-1.8
Patch foraging water rate 18 sec	0.3	0.4	1.2	-0.2	0.6	-0.7	-0.4	0.6	-1.1
Patch foraging water rate 24 sec	0.8	1.1	3.0	1.1	0.8	-0.7	1.2	1.7	0.2
Patch foraging water rate 6 sec	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.1	0.2	-0.1
Seeking ratio, delayed vs. immediate footshock	2.2	2.7	5.6	1.4	1.7	-1.7	1.2	2.4	-1.0
Distance traveled before self-admin	1.4	1.8	2.5	1.4	1.6	-1.5	1.1	1.5	-0.8
Distance traveled after self-admin	0.2	0.2	0.5	-0.7	-0.3	0.2	-0.7	0.5	-0.3
Extensor digitorum longus weight	1.1	4.3	7.6	-1.3	-2.6	2.8	-0.6	-1.5	2.6
Bone: elastic displacement	0.4	0.5	1.3	-1.1	-0.5	0.3	-1.1	-0.0	-0.5
Bone: elastic work	0.4	0.6	1.0	0.5	1.0	-1.0	0.2	0.5	-1.0
Bone: endosteal estimation	2.3	5.1	8.6	2.3	2.9	-2.9	1.6	1.5	-1.9
Bone: endosteal perimeter	2.4	5.1	8.2	2.3	2.9	-2.8	1.8	1.7	-1.7
Epididymis fat weight	0.5	1.8	4.6	2.0	0.9	-0.6	2.1	0.3	1.0
Delta time in closed arm before/after self-admin	0.4	0.3	1.3	-0.2	-0.5	0.5	-0.2	-1.1	0.5
Delta time in open arm before/after self-admin	3.9	3.8	6.1	1.6	2.4	-2.5	1.0	1.8	-2.0
Diff in mean of infusions in LGA sessions	0.5	0.6	1.5	-0.3	0.6	-0.7	-0.5	1.1	-1.2
Delay discount exponential model param	0.2	0.2	0.5	0.6	0.0	0.1	0.7	-0.2	0.7
Extinction: sum of active levers before priming	0.3	0.3	0.5	0.7	0.4	-0.4	0.7	0.7	0.1
Active lever presses in extinction session 6	0.5	0.5	1.5	-0.1	0.7	-0.8	-0.5	0.1	-1.2
Bone: final force	0.9	1.5	3.5	1.9	1.0	-0.8	1.8	0.0	0.5
Bone: final moment	0.8	1.2	3.1	1.7	0.8	-0.5	1.8	-0.1	0.7
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.3	-0.1	0.1	0.3	-0.4	0.4
Glucose	0.7	1.1	3.7	0.4	-0.9	1.1	0.9	-0.2	1.9
Heart weight	0.4	0.6	1.5	0.5	0.8	-0.8	0.4	1.2	-0.6
Delay discount hyperbolic model param	0.3	0.3	0.6	0.7	0.0	0.1	0.8	-0.3	0.7
Intermittent access intake day 1-15 change	0.3	0.6	1.2	-0.5	-1.0	1.1	-0.2	-0.2	1.1
Intermittent access intake escalation	0.5	1.0	1.8	-0.7	-1.3	1.3	-0.4	-0.5	1.2
Intermittent access intake escalation 2	0.1	0.1	0.3	0.2	-0.1	0.1	0.4	0.5	0.4
Intermitt. access day 1 inactive lever presses	1.0	3.6	5.9	-1.5	-2.4	2.4	-0.9	-1.7	2.0
Intermitt. access day 15 inactive lever presses	0.3	0.6	0.9	-0.6	-0.9	1.0	-0.4	-0.8	0.8
Intermitt. access escalation Index	0.7	1.0	2.1	1.2	0.1	0.2	1.5	-0.6	1.3
Intermittent access day 1 total infusions	0.1	0.1	0.5	0.1	0.2	-0.2	-0.1	-0.7	-0.2
Intermittent access day 15 total infusions	0.7	1.0	1.7	-0.7	-1.1	1.2	-0.5	-1.3	1.0
Intermittent access terminal intake (last 3 days)	0.7	0.9	1.3	-0.8	-1.1	1.1	-0.6	-1.1	0.8
Intermittent access total infusions	0.3	0.3	1.1	-0.3	-0.5	0.5	-0.3	-1.0	0.4
Intermittent access day 1 locomotion	0.2	0.3	0.9	-0.4	-0.2	0.2	-0.6	-1.0	-0.2
Intermittent access day 15 total locomotion	0.0	0.1	0.2	-0.3	0.1	-0.1	-0.4	-0.2	-0.4
Intermittent access total locomotion	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.4	-0.4	0.1
Intermittent access standard deviation	0.3	0.6	0.9	-0.8	-0.9	0.9	-0.7	-0.8	0.5
Left kidney weight	0.3	1.3	3.3	0.7	1.1	-1.2	0.6	1.8	-0.8
Right kidney weight	0.7	3.3	10.4	1.1	1.6	-1.7	1.1	3.2	-1.1
Cocaine induced anxiety	0.1	0.1	0.3	0.3	0.0	0.1	0.3	-0.6	0.3
Post-drug Anxiety	0.1	0.1	0.4	0.5	0.3	-0.2	0.6	0.2	0.2
Baseline Anxiety	0.3	0.3	0.8	0.4	0.6	-0.6	0.3	0.9	-0.4
Tail length	6.7	26.3	40.4	6.4	6.0	-5.5	5.6	4.0	-1.9
Length with tail	7.5	32.7	50.5	7.1	6.6	-6.1	6.3	4.5	-2.0
Length without tail	2.9	9.3	13.2	3.3	3.6	-3.5	2.8	2.8	-1.7
Times rat made contact with spout	0.2	0.2	0.6	0.4	-0.2	0.4	0.5	-0.6	0.8
Lifetime Intake	0.5	0.6	1.2	-0.5	-0.9	0.9	-0.3	-1.1	0.8
Liver weight, left	3.8	6.2	12.2	3.5	2.5	-2.1	3.4	1.7	0.3
Liver weight, right	1.2	2.1	2.9	1.7	1.5	-1.4	1.6	1.7	-0.4
Locomotor activity	0.1	0.1	0.5	0.1	0.0	0.0	0.1	-0.7	0.1
Locomotor testing distance	0.1	0.2	0.3	-0.4	0.1	-0.2	-0.5	-0.5	-0.6
Locomotor testing rearing	0.1	0.2	0.3	0.6	0.5	-0.4	0.6	0.5	-0.0
Locomotion in novel chamber	1.5	1.9	3.3	-1.8	-1.4	1.3	-1.7	-1.2	0.1
Locomotion in novel chamber post-restriction	0.8	1.3	2.1	-0.8	-1.3	1.3	-0.6	-1.5	1.0
Fecal boli incidents, locomotor time 1	1.9	2.8	4.8	0.8	2.0	-2.2	0.3	1.6	-2.2
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	-0.5	-0.7	0.7	-0.4	-0.6	0.5
Time >=10cm from walls, locomotor time 1	1.5	1.5	4.6	-1.1	0.5	-0.9	-1.6	0.0	-2.1
Bouts of movement, locomotor time 1	0.4	0.5	1.3	-0.6	-0.1	0.0	-0.9	-1.2	-0.6
Total resting periods, locomotor time 1	1.4	1.6	3.3	-1.5	-0.8	0.7	-1.7	-1.8	-0.5
Rest time, locomotor task time 1	1.4	1.8	6.1	-0.8	-1.1	1.2	-0.8	-2.5	0.7
Distance moved, locomotor task time 1	1.1	1.7	4.7	0.5	1.2	-1.3	0.3	2.2	-1.3
Vertical activity count, locomotor time 1	0.2	0.6	1.9	0.7	0.2	-0.2	0.9	1.4	0.5
Time >=10cm from walls, locomotor time 2	1.4	2.0	6.1	-0.5	1.2	-1.5	-1.1	1.0	-2.5
Bouts of movement, locomotor time 2	0.6	1.0	2.5	-1.5	-0.5	0.3	-1.6	0.1	-0.9
Total resting periods, locomotor time 2	0.7	1.3	3.2	-1.7	-0.7	0.5	-1.8	-0.4	-0.8
Rest time, locomotor task time 2	1.3	1.7	4.9	-0.5	-1.2	1.3	-0.3	-2.2	1.3
Distance moved, locomotor task time 2	1.3	1.6	3.9	0.2	1.1	-1.3	-0.1	2.0	-1.6
Vertical activity count, locomotor time 2	0.3	0.4	2.0	-0.1	0.1	-0.2	-0.0	1.4	-0.2
Light reinforcement 1	1.0	2.4	4.2	-1.3	-2.0	2.1	-0.8	-1.0	1.7
Light reinforcement 2	0.2	0.3	0.7	-0.7	0.0	-0.2	-0.8	0.5	-0.8
Bone: marrow area	2.2	4.8	8.1	2.2	2.8	-2.8	1.6	1.5	-1.9
Bone: maximum diameter	0.3	0.5	0.9	0.5	0.9	-0.9	0.2	-0.2	-0.9
Bone: maximum force	1.7	3.1	5.8	2.4	1.9	-1.7	2.2	1.0	-0.2
Bone: maximum moment	1.3	2.4	4.7	2.2	1.6	-1.4	2.0	0.9	-0.0
Mean time between licks in bursts	0.4	0.9	2.1	-0.1	-1.0	1.1	0.3	-0.9	1.5
Mean num. licks in bursts	0.2	0.3	0.6	0.8	0.2	-0.0	0.8	-0.4	0.6
Cd content in liver	0.2	0.2	0.4	0.6	0.4	-0.3	0.6	0.5	0.1
Co content in liver	0.3	0.3	0.7	-0.1	-0.5	0.6	0.0	-0.9	0.7
Cu content in liver	0.2	0.3	0.6	0.2	0.5	-0.5	0.1	0.8	-0.6
Fe content in liver	1.2	1.5	2.3	1.3	1.5	-1.5	1.1	1.0	-0.8
K content in liver	0.3	0.3	0.9	0.0	0.4	-0.4	-0.0	0.9	-0.5
Mg content in liver	0.8	0.8	2.8	0.4	0.8	-0.9	0.3	1.7	-0.8
Mn content in liver	1.9	2.1	2.9	-1.5	-1.7	1.6	-1.3	-1.5	0.8
Na content in liver	1.0	1.1	1.8	0.5	1.2	-1.3	0.1	1.1	-1.4
Rb content in liver	1.1	1.3	2.7	-0.1	1.0	-1.2	-0.4	1.5	-1.6
Se content in liver	0.0	0.1	0.1	-0.3	0.0	-0.1	-0.3	0.1	-0.4
Sr content in liver	1.1	1.0	2.2	0.9	-0.2	0.5	1.2	-1.1	1.5
Zn content in liver	0.3	0.3	0.6	0.8	0.4	-0.3	0.8	0.6	0.2
Bone: minimum diameter	0.2	0.3	0.6	0.5	0.7	-0.7	0.3	-0.3	-0.6
Time in familiar zone, hab. session 1	0.4	0.4	0.9	0.8	0.2	-0.0	1.0	0.5	0.7
Time in novel zone, hab. session 1	0.3	0.3	0.9	-0.8	-0.2	0.0	-0.9	-0.4	-0.7
Total zone transitions, hab. session 1	0.2	0.3	1.0	-0.4	0.3	-0.5	-0.6	0.4	-1.0
Total locomotion distance, hab. session 1	0.4	0.6	1.9	-0.6	0.4	-0.6	-0.9	0.1	-1.4
Locomotion velocity, hab. session 1	0.2	0.2	0.7	0.0	0.5	-0.6	-0.2	0.2	-0.8
Time in familiar zone, hab. session 2	1.1	1.2	1.8	-1.4	-1.3	1.1	-1.2	-0.9	0.4
Time in novel zone, hab. session 2	0.4	0.4	0.7	0.8	0.6	-0.5	0.8	0.5	0.0
Total zone transitions, hab. session 2	0.2	0.3	0.8	0.8	0.2	-0.1	0.9	0.3	0.6
Total locomotion distance, hab. session 2	0.4	0.5	1.2	1.0	0.4	-0.3	1.1	0.4	0.5
Locomotion velocity, hab. session 2	0.5	0.7	1.8	1.3	0.6	-0.4	1.3	0.4	0.6
Novel to familiar place preference ratio	0.9	1.0	1.5	1.0	1.2	-1.2	0.8	1.0	-0.7
Novelty place preference	1.0	1.1	1.5	1.1	1.2	-1.2	0.9	1.1	-0.7
Time in novel zone, NPP test	0.8	0.9	1.2	0.9	1.1	-1.1	0.7	1.1	-0.7
Total zone transitions, NPP test	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.2	-0.4	0.3
Total locomotion distance, NPP test	0.2	0.3	0.6	-0.8	-0.5	0.4	-0.8	-0.4	-0.1
Locomotion velocity, NPP test	0.3	0.4	0.5	-0.7	-0.6	0.6	-0.6	-0.7	0.2
Intraocular pressure	2.3	3.3	4.7	-1.9	-2.2	2.1	-1.6	-1.9	1.2
Delta distance traveled before/after self-admin	1.2	1.2	1.8	-1.4	-1.3	1.3	-1.1	-0.8	0.5
Delta ambulatory time before/after self-admin	1.2	1.5	2.2	-1.5	-1.4	1.3	-1.3	-1.1	0.5
Parametrial fat weight	0.5	1.1	2.7	-0.0	-1.0	1.2	0.4	-1.2	1.6
Pavlov. Cond. lever latency	0.6	0.7	2.4	0.3	-0.7	0.9	0.7	-0.1	1.5
Pavlov. Cond. magazine entry latency	0.8	1.0	3.0	-0.8	0.4	-0.7	-1.3	-0.3	-1.7
Pavlov. Cond. change in total contacts	1.5	1.6	3.9	-1.4	0.2	-0.5	-1.8	-0.3	-2.0
Pavlov. Cond. index score	0.6	0.7	2.0	-0.7	0.4	-0.6	-1.1	-0.5	-1.4
Pavlov. Cond. latency score	0.7	0.9	2.8	-0.5	0.7	-0.9	-0.9	-0.0	-1.7
Pavlov. Cond. lever contacts	0.6	0.7	2.0	-0.7	0.4	-0.6	-1.0	-0.2	-1.4
Pavlov. Cond. magazine entry number	0.6	0.7	2.3	0.5	-0.6	0.8	0.9	0.0	1.5
Pavlov. Cond. intertrial magazine entries	1.0	1.2	2.0	1.3	1.0	-0.9	1.3	1.4	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.0	-1.0	0.2	-0.4	-1.4	-0.7	-1.4
Pavlov. Cond. response bias	0.5	0.6	1.6	-0.7	0.3	-0.5	-1.0	-0.5	-1.3
Pavlov. Cond. lever latency	1.6	2.2	4.8	1.8	0.7	-0.4	2.2	1.7	1.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.3	-0.2	0.2	-0.4	-0.6	-0.1
Pavlov. Cond. change in total contacts	1.4	2.3	5.4	-1.9	-0.3	-0.0	-2.3	-1.4	-1.7
Pavlov. Cond. index score	1.2	1.6	3.5	-1.5	-0.5	0.3	-1.9	-1.5	-1.0
Pavlov. Cond. latency score	1.0	1.4	2.9	-1.4	-0.5	0.3	-1.7	-1.5	-0.9
Pavlov. Cond. lever contacts	1.9	2.7	6.2	-2.0	-0.6	0.2	-2.5	-1.6	-1.6
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.3	-0.1	0.2	0.5	0.6	0.6
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.2	-0.3	-0.1	0.0	-0.2	0.5	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.7	3.7	-1.6	-0.5	0.3	-1.9	-1.5	-1.1
Pavlov. Cond. response bias	1.0	1.3	2.7	-1.2	-0.0	-0.2	-1.7	-1.2	-1.5
Time in closed arm before self-admin	1.1	1.4	2.3	1.2	1.5	-1.5	0.9	0.6	-0.9
Time in closed arm after self-admin	0.6	0.6	2.0	-0.3	0.6	-0.8	-0.7	0.3	-1.4
Time in open arm before self-admin	4.7	5.1	8.2	-1.4	-2.7	2.9	-0.7	-2.3	2.7
Time in open arm after self-admin	0.1	0.2	0.3	0.4	0.5	-0.5	0.3	-0.2	-0.3
Bone: periosteal estimation	1.1	2.4	4.2	1.6	2.1	-2.0	1.1	0.7	-1.4
Bone: periosteal perimeter	0.9	1.5	2.6	1.2	1.6	-1.6	0.9	0.8	-1.1
Bone: post-yield work	1.0	1.4	2.4	1.5	1.2	-1.0	1.5	1.2	0.0
Progressive ratio test 1 active lever presses	0.8	1.0	2.9	-0.6	-1.0	1.0	-0.5	-1.7	0.7
Progressive ratio test 1 breakpoint	0.6	0.7	2.1	-0.6	-0.7	0.8	-0.5	-1.5	0.5
Progressive ratio test 1 inactive lever presses	2.7	3.9	7.3	-0.7	-2.2	2.4	-0.0	-2.2	2.7
Progressive ratio test 2 active lever presses	0.8	1.0	3.7	-0.2	-0.7	0.8	-0.1	-1.9	0.9
Progressive ratio test 2 breakpoint	0.8	1.0	3.5	-0.3	-0.8	0.9	-0.2	-1.9	0.8
Progressive ratio test 2 inactive lever presses	0.8	1.4	3.8	-0.5	-1.1	1.2	-0.3	-1.9	1.2
Incentive Sensitization - Responses	0.2	0.2	0.6	0.6	0.3	-0.2	0.5	-0.8	0.2
Incentive Sensitization - Breakpoint	0.1	0.2	0.4	0.6	0.3	-0.1	0.5	-0.7	0.2
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.2	0.7	1.1	-1.1	0.4	0.6	-0.9
Progressive ratio	0.4	0.6	1.5	-0.5	-0.8	0.9	-0.3	-1.2	0.8
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.3	0.0	0.0	0.4	0.3	0.3
Seeking ratio, punishment vs. effort	1.5	2.2	5.0	1.3	1.5	-1.5	1.2	2.2	-0.8
Retroperitoneal fat weight	0.4	1.6	3.7	1.5	-0.1	0.4	1.9	-0.1	1.9
Reaction time number correct	0.1	0.3	0.6	-0.8	-0.4	0.3	-0.8	0.2	-0.2
Reaction time mean minus median	0.3	0.6	1.3	1.0	0.2	0.1	1.1	-0.6	1.0
Reaction time mean minus median AUC	0.1	0.2	0.4	0.6	0.1	-0.0	0.6	-0.5	0.5
Reaction time num false alarms	1.6	2.3	3.9	-1.4	-2.0	1.9	-1.0	-1.1	1.4
Reaction time num false alarms AUC	1.6	2.5	4.3	-1.4	-2.1	2.1	-0.9	-1.1	1.7
Reaction time trials correct on left	0.1	0.3	0.6	-0.8	-0.4	0.3	-0.8	0.2	-0.2
Reaction time trials on left	0.1	0.2	0.5	-0.7	-0.4	0.3	-0.7	0.2	-0.2
Reaction time mean	0.6	1.0	2.2	1.5	0.7	-0.5	1.4	-0.7	0.6
Reaction time mean AUC	0.6	0.9	1.8	1.3	0.4	-0.1	1.3	-1.0	0.9
Median of all reaction times	0.6	0.8	1.9	1.4	0.8	-0.5	1.3	-0.7	0.4
Reaction time omissions	0.4	0.5	1.4	1.1	0.4	-0.2	1.2	-0.1	0.6
Reaction time false alarm rate	1.0	1.4	2.5	-0.8	-1.5	1.6	-0.4	-1.0	1.4
Reaction time premature initiation rate	3.0	4.2	9.9	-2.9	-1.4	1.0	-3.2	-1.6	-1.3
Reaction time premature initiations	2.4	4.3	10.3	-3.0	-1.5	1.1	-3.2	-1.2	-1.2
Std. dev. reaction times	0.5	0.9	2.2	1.5	0.9	-0.7	1.4	0.0	0.3
Reaction time trials completed	0.1	0.2	0.5	-0.7	-0.4	0.3	-0.7	0.2	-0.2
Reaction time trials AUC	0.1	0.2	0.5	-0.7	-0.5	0.4	-0.7	0.1	-0.1
Run reversals in cocaine runway, females	0.3	0.3	0.8	0.8	0.3	-0.2	0.9	0.3	0.5
Run reversals in cocaine runway, males	1.0	1.0	2.6	-1.4	-0.4	0.1	-1.6	-0.7	-1.0
Latency to leave start box in cocaine runway	3.2	3.7	5.7	-2.1	-2.4	2.3	-1.6	-1.6	1.3
Latency to leave start box in cocaine runway, F	2.7	3.1	5.1	-1.6	-2.3	2.3	-1.1	-1.4	1.7
Latency to leave start box in cocaine runway, M	1.0	0.9	1.9	-1.4	-1.0	0.8	-1.3	-0.6	-0.1
Std. dev. time between licks in bursts	2.0	2.7	4.4	-1.6	-2.1	2.1	-1.1	-1.4	1.4
Total sessions with >9 infusions	1.8	2.2	3.8	-1.1	-1.7	1.7	-0.8	-1.9	1.3
Short access day 1 total inactive lever presses	0.5	0.6	1.1	-1.1	-0.8	0.7	-1.0	-0.6	0.0
Short access day 10 total inactive lever presses	0.1	0.2	0.4	-0.5	-0.6	0.6	-0.4	-0.1	0.3
Short access day 1 total infusions	1.0	1.4	3.1	-0.5	-1.2	1.3	-0.2	-1.8	1.3
Short access day 10 total infusions	0.4	0.5	0.7	-0.9	-0.8	0.8	-0.8	-0.6	0.3
Short access total infusions	1.1	1.3	1.8	-1.1	-1.4	1.3	-0.9	-1.4	0.8
Short access day 1 locomotion	1.1	1.4	3.4	-0.7	-1.2	1.2	-0.5	-1.9	1.0
Short access day 10 total locomotion	0.7	1.2	3.2	-1.7	-0.8	0.6	-1.8	-0.3	-0.7
Short access total locomotion	0.6	0.7	1.1	-0.6	-1.0	1.1	-0.4	-0.7	0.9
One hour access (0.3 mA shock)	0.3	0.3	0.9	-0.5	-0.5	0.4	-0.5	-0.9	0.1
Compulsive drug intake	0.2	0.2	0.7	0.0	-0.5	0.6	0.3	-0.2	0.8
One hour access (shock baseline)	0.1	0.2	0.4	-0.5	-0.0	-0.1	-0.7	-0.1	-0.6
Social response proportion	2.9	3.3	4.4	1.8	2.1	-2.0	1.5	2.1	-1.2
Social responses	1.0	1.3	2.7	1.5	0.9	-0.8	1.6	1.1	0.4
Social time	0.2	0.3	0.7	0.7	0.2	-0.1	0.8	0.0	0.6
Soleus weight	0.2	0.6	0.9	0.3	0.8	-0.9	0.2	1.0	-0.9
Bone: stiffness	3.1	5.1	9.6	3.1	2.2	-1.8	3.0	1.8	0.2
Tibialis anterior weight	0.3	0.9	1.5	-0.7	-1.2	1.2	-0.4	-1.0	1.0
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	0.6	0.2	-0.1	0.6	-0.5	0.3
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	0.5	0.4	-0.3	0.5	-0.1	-0.0
Time to tail flick, test, before self-admin	1.1	1.1	1.9	-1.4	-1.0	0.9	-1.4	-1.1	-0.0
Time to tail flick, test, after self-admin	0.3	0.3	1.0	0.1	-0.6	0.7	0.4	-0.4	1.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.0	0.3	0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.4	0.3	-0.2	0.3	0.5	-0.3	0.6
Tibia length	3.3	9.1	17.0	4.1	3.4	-3.0	3.8	1.6	-0.5
Ambulatory time before self-admin	1.6	2.4	4.8	1.6	1.6	-1.5	1.5	2.2	-0.5
Ambulatory time after self-admin	0.3	0.4	0.8	-0.9	-0.6	0.4	-0.8	0.6	-0.1
Bone: tissue strength	2.2	2.2	5.4	2.1	0.8	-0.5	2.3	1.1	1.2
Total heroin consumption	0.0	0.0	0.0	0.1	0.2	-0.2	0.1	-0.0	-0.2
Bone: trabecular number	3.6	6.0	8.6	2.5	2.9	-2.9	2.0	2.5	-1.7
Bone: trabecular spacing	0.4	0.5	0.9	-0.8	-0.7	0.6	-0.8	-0.9	0.1
Bone: trabecular thickness	1.3	1.6	2.7	0.9	1.6	-1.6	0.5	1.1	-1.4
Bone: trabecular tissue density	1.3	1.9	6.4	-0.3	-1.2	1.3	-0.1	-2.5	1.4
Water consumed over 24 hours	0.1	0.2	0.3	-0.4	-0.5	0.5	-0.3	-0.5	0.3
Number of responses in last shaping day	0.7	0.8	2.3	0.3	-0.7	0.9	0.7	-0.8	1.5