Hub : Genes

Plce1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc isoform ratio XM_063262818.1 0.02 0.01 5.1e-03 0.01 0.01 0.01 0 1.8e-02 2.0e-02 3.3e-02 1.1e-01
2 Liver isoform ratio XM_039108292.2 0.06 0.03 2.5e-05 0.02 0.03 0.02 0.02 2.8e-03 1.6e-04 1.7e-03 1.1e-03
3 Brain intron excision ratio chr1_245898706_245901140 0.02 0.02 4.4e-03 0.02 0.02 0.02 0.02 5.2e-03 4.7e-03 5.3e-03 4.5e-03
4 Brain intron excision ratio chr1_245898484_245898570 0.02 0.02 6.7e-03 0.02 0.02 0.01 0.02 2.8e-03 8.3e-03 7.8e-02 1.1e-02
5 Liver isoform ratio XM_063262818.1 0.11 0.06 3.4e-08 0.02 0.05 0.03 0.03 4.7e-03 6.1e-06 4.1e-04 5.5e-04
6 Adipose gene expression Plce1 0.09 0.06 7.8e-06 0.02 0.04 0.04 0.04 1.3e-03 1.8e-05 2.3e-05 1.2e-05
7 Liver alternative TSS XM_063262818.1 0.14 0.07 2.0e-09 0.03 0.06 0.04 0.04 9.3e-05 3.0e-07 1.9e-05 5.1e-05
8 Liver alternative TSS XM_039108292.2 0.16 0.09 9.1e-11 0.05 0.07 0.06 0.05 3.2e-06 3.3e-08 5.8e-07 1.5e-06
9 Liver alternative TSS XM_063262818.1 0.15 0.08 5.7e-10 0.04 0.06 0.05 0.05 8.0e-06 1.4e-07 2.9e-06 3.2e-06
10 PL gene expression Plce1 0.09 0.06 6.4e-05 0.05 0.04 0.03 0.05 3.7e-06 1.5e-05 1.3e-04 4.7e-06
11 BLA alternative TSS NM_053758.2 0.09 0.05 1.3e-03 0.05 0.06 0.05 0.05 1.1e-03 7.0e-04 1.8e-03 1.7e-03
12 NAcc alternative TSS XM_063262818.1 0.02 0.01 4.0e-03 0 0.01 0.01 0 5.0e-02 1.5e-02 2.2e-02 2.8e-01
13 Liver alternative TSS NM_053758.2 0.22 0.14 1.0e-03 0.02 0.01 0.02 0.02 1.9e-03 3.9e-02 3.7e-03 9.1e-04
14 BLA alternative TSS XM_039108292.2 0.16 0.09 3.3e-05 0.1 0.08 0.07 0.08 6.1e-06 3.6e-05 8.8e-05 4.4e-05
15 BLA gene expression Plce1 0.09 0.06 9.3e-04 0.07 0.06 0.05 0.06 1.5e-04 4.6e-04 1.4e-03 2.8e-04
16 Brain gene expression Plce1 0.06 0.04 4.8e-03 0.02 0.02 0.02 0.02 8.8e-03 4.1e-03 2.3e-03 7.8e-03
17 IC mRNA stability Plce1 0.14 0.09 3.4e-03 0.03 0.06 0 0.04 1.4e-02 1.1e-03 1.9e-01 7.4e-03
18 BLA isoform ratio XM_039108292.2 0.11 0.08 3.3e-03 0.02 0.05 0.03 0.02 2.1e-02 1.2e-03 1.0e-02 3.7e-02
19 Liver mRNA stability Plce1 0.43 0.13 2.6e-12 0.09 0.1 0.07 0.09 1.9e-10 6.6e-11 4.7e-08 5.0e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bone: apparent density1.73.16.52.02.2-2.6-2.6-2.02.2-1.91.8-1.8-1.4-1.3-0.71.2-1.5-1.5-2.1-1.30.4-1.2
Area under the delay curve0.71.12.9-1.4-1.10.60.61.1-0.21.1-1.11.11.21.41.7-1.21.01.00.2-1.1-1.30.5
BMI with tail0.20.92.70.31.1-0.7-0.7-1.11.7-1.21.2-1.2-1.1-0.5-0.00.8-0.7-0.7-1.0-1.1-0.4-0.6
BMI without tail0.00.10.40.20.10.50.5-0.1-0.2-0.20.2-0.2-0.7-0.2-0.20.0-0.0-0.00.20.0-0.00.2
Body weight0.31.13.61.41.0-0.1-0.1-1.0-0.7-1.01.1-1.0-1.9-1.3-1.41.2-1.2-1.2-0.31.01.1-0.3
Weight adjusted by age0.20.51.6-1.10.20.10.1-0.41.2-0.60.5-0.50.4-0.00.80.20.50.5-1.3-0.9-0.2-1.2
Bone surface1.73.36.02.32.3-2.4-2.4-2.11.8-2.12.0-2.0-2.0-1.5-1.11.6-1.6-1.6-1.9-1.00.6-1.1
Bone volume2.04.16.02.12.5-2.4-2.4-2.41.6-2.32.3-2.3-2.1-2.0-1.51.9-1.9-1.9-2.3-0.41.2-1.6
Breakpoint value in progressive ratio session0.50.92.6-0.5-0.80.20.21.0-1.41.1-1.11.10.71.00.7-1.11.11.11.2-0.5-0.91.6
Number of licking bursts0.82.35.4-1.7-1.60.90.91.6-0.21.5-1.61.52.02.02.3-1.61.71.70.4-1.3-1.80.6
Context. condit. distance diff. score0.91.02.11.41.2-1.4-1.4-1.10.9-1.01.1-1.0-0.9-0.9-0.91.0-1.0-1.0-0.8-0.10.4-0.6
Locomotion velocity, session 12.52.96.2-1.2-2.00.90.92.0-0.82.0-2.12.12.52.12.1-2.01.51.51.3-0.8-1.61.1
Locomotion distance, session 11.01.33.0-1.0-1.40.70.71.3-0.71.3-1.31.31.71.41.5-1.41.01.00.6-0.5-1.20.6
Locomotion velocity, session 21.31.55.30.8-0.1-1.1-1.10.70.40.9-1.01.01.51.41.2-1.40.90.90.8-2.3-2.01.8
Locomotion distance, session 20.60.92.5-0.2-0.6-0.3-0.30.8-0.50.8-0.90.91.11.21.1-1.30.70.70.7-1.3-1.61.2
Locomotion velocity, session 30.10.20.60.80.5-0.7-0.7-0.4-0.2-0.30.3-0.3-0.0-0.3-0.50.3-0.5-0.5-0.2-0.10.20.1
Locomotion distance, session 31.01.13.21.40.8-0.4-0.4-0.8-0.4-0.70.8-0.8-1.0-1.3-1.81.0-1.2-1.2-0.31.61.6-0.6
Stereotopy head waving bouts, day 30.20.20.8-0.10.0-0.4-0.4-0.10.9-0.10.0-0.10.20.20.70.20.20.2-0.8-0.7-0.2-0.8
Stereotopy head waving duration, day 30.40.51.9-0.6-0.1-0.5-0.50.11.20.0-0.10.10.80.71.2-0.10.50.5-0.8-1.4-0.9-0.6
Locomotion velocity, session 72.93.24.72.01.9-1.8-1.8-2.01.1-1.91.9-1.9-1.5-1.8-1.62.1-2.2-2.2-1.90.51.3-1.8
Locomotion distance, session 72.22.84.32.11.9-1.7-1.7-1.80.6-1.81.8-1.8-1.6-1.9-1.91.9-2.0-2.0-1.30.71.4-1.2
Stereotopy head waving bouts, day 70.81.02.0-0.1-0.90.10.11.00.81.2-1.21.21.11.21.3-1.01.41.40.5-0.8-0.80.5
Stereotopy head waving duration, day 70.20.20.80.1-0.5-0.0-0.00.50.90.6-0.60.60.40.50.6-0.20.60.60.1-0.2-0.1-0.2
Locomotion velocity, session 80.10.20.50.70.2-0.7-0.7-0.10.5-0.00.00.00.50.20.1-0.0-0.1-0.1-0.0-0.6-0.60.2
Locomotion distance, session 80.40.62.70.70.5-1.5-1.5-0.20.9-0.20.1-0.10.30.40.5-0.40.20.2-0.2-1.6-1.30.7
Degree of sensitization distance0.20.21.50.10.2-0.6-0.60.00.4-0.0-0.00.00.40.50.7-0.10.30.3-0.1-1.2-1.00.3
Degree of sensitization stereotypy1.41.52.8-0.1-1.30.70.71.40.21.6-1.61.61.21.41.2-1.41.71.71.3-0.4-0.91.3
Conditioned locomotion1.31.62.8-0.10.9-0.2-0.2-1.20.2-1.31.3-1.3-1.5-1.5-1.31.5-1.7-1.7-1.11.31.6-1.6
Cocaine response after cond. corrected0.20.20.7-0.4-0.40.30.30.5-0.20.5-0.50.50.40.70.4-0.20.40.40.6-0.5-0.80.6
Cocaine response after cond. not corrected0.30.40.9-0.1-0.40.20.20.6-0.30.6-0.70.70.70.80.5-0.30.60.60.7-0.7-1.01.0
Cocaine response before conditioning0.30.30.90.2-0.50.20.20.6-0.40.7-0.70.70.90.70.6-0.60.60.60.4-0.4-0.60.7
Saline control response2.33.24.5-1.9-2.01.51.52.0-1.72.0-2.12.01.71.71.7-2.12.02.02.0-0.1-1.11.7
Bone: connectivity density2.74.48.32.32.6-2.9-2.9-2.42.7-2.32.2-2.2-2.0-1.6-0.91.6-1.8-1.8-2.3-1.50.6-1.3
Bone: cortical apparent density0.81.32.4-1.0-1.20.60.61.20.81.2-1.21.21.41.31.5-1.21.61.60.7-0.7-1.10.5
Bone: cortical area1.11.83.91.81.3-0.8-0.8-1.3-0.8-1.21.3-1.3-1.8-1.8-2.01.5-1.2-1.2-0.51.51.9-0.7
Bone: cortical porosity0.80.84.10.90.6-1.4-1.4-0.41.5-0.40.3-0.30.20.50.7-0.2-0.2-0.2-0.8-2.0-1.40.1
Bone: cortical porosity0.60.62.11.40.8-1.4-1.4-0.51.1-0.50.4-0.4-0.10.10.10.1-0.4-0.4-0.6-1.5-0.80.2
Bone: cortical thickness0.71.24.7-0.7-1.21.51.51.0-2.21.1-1.01.00.60.3-0.1-0.50.90.91.31.60.50.6
Bone: cortical thickness1.82.23.6-1.2-1.91.51.51.8-1.41.8-1.71.71.71.61.4-1.71.61.61.40.2-0.91.0
Bone: cortical tissue density0.81.32.6-1.0-1.20.50.51.21.01.1-1.21.21.51.41.6-1.21.61.60.6-0.9-1.20.5
Condit. Reinf. active minus inactive responses0.10.10.50.4-0.3-0.1-0.10.4-0.70.5-0.40.50.50.3-0.1-0.40.10.10.50.3-0.00.4
Condit. Reinf. active-inactive response ratio0.10.10.50.1-0.30.10.10.3-0.40.4-0.40.40.00.1-0.3-0.30.10.10.70.50.20.4
Condit. Reinf. active responses0.10.11.00.4-0.20.10.10.2-1.00.3-0.20.20.30.0-0.4-0.1-0.2-0.20.40.70.20.1
Condit. Reinf. inactive responses0.00.00.4-0.1-0.20.10.10.1-0.60.1-0.00.10.50.20.1-0.1-0.1-0.10.00.1-0.2-0.1
Incentive salience index mean0.50.72.3-0.2-0.90.80.80.9-1.51.0-0.90.90.90.60.1-0.90.60.61.10.5-0.21.0
Condit. Reinf. lever presses1.21.83.5-1.3-1.61.81.81.5-1.91.4-1.41.41.41.10.6-1.21.21.21.40.6-0.51.2
Condit. Reinf. active minus inactive responses2.33.64.91.52.1-1.8-1.8-2.21.7-2.22.2-2.2-2.1-1.9-1.32.0-2.1-2.1-2.2-0.11.3-1.9
Condit. Reinf. active-inactive response ratio1.22.04.00.81.5-1.4-1.4-1.62.0-1.71.6-1.6-1.5-1.2-0.61.4-1.5-1.5-1.7-0.60.5-1.5
Condit. Reinf. active responses1.31.93.10.71.2-0.5-0.5-1.50.2-1.51.6-1.6-1.8-1.7-1.41.7-1.7-1.7-1.31.11.7-1.6
Condit. Reinf. inactive responses0.60.94.4-0.4-0.71.41.40.5-2.10.5-0.40.4-0.1-0.3-0.80.1-0.0-0.00.72.01.10.1
Condit. Reinf. lever presses0.20.30.7-0.8-0.60.50.50.6-0.60.6-0.60.60.20.40.5-0.70.20.20.60.1-0.20.4
Condit. Reinf. lever reinforcers received0.71.01.70.30.8-0.3-0.3-1.0-0.0-1.11.1-1.1-1.3-1.2-1.01.1-1.3-1.3-1.00.81.2-1.2
Conditioned reinforcement - actives0.20.63.01.0-0.2-0.3-0.30.60.10.8-0.80.90.70.60.2-0.90.70.71.2-0.6-0.71.7
Conditioned reinforcement - inactives0.30.85.32.30.3-1.2-1.20.21.20.5-0.50.51.10.60.1-0.10.50.50.5-1.1-0.90.9
Conditioned locomotion0.10.20.50.6-0.30.30.30.40.00.5-0.50.50.50.2-0.1-0.40.40.40.70.40.20.5
Patch foraging indifference point 0 sec0.30.83.4-1.0-0.91.01.00.9-1.80.9-0.90.90.30.30.0-0.70.50.51.01.00.40.7
Patch foraging indifference point AUC2.56.08.5-2.0-2.82.32.32.8-2.52.9-2.92.92.62.52.0-2.72.52.52.70.1-1.62.3
Delay disc. indifference point, 0s delay0.70.72.7-0.00.9-1.1-1.1-0.81.6-0.70.6-0.7-0.2-0.20.4-0.1-0.9-0.9-1.2-1.5-0.3-0.4
Delay disc. indifference point, 16s delay1.01.32.4-0.7-1.11.01.01.2-0.81.2-1.31.31.01.41.3-1.31.51.50.8-0.8-1.31.1
Delay disc. indifference point, 2s delay0.30.41.5-1.0-0.1-0.5-0.50.10.9-0.0-0.10.0-0.20.51.2-0.40.20.2-0.8-1.1-0.7-0.6
Delay disc. indifference point, 24s delay1.42.33.2-0.8-1.71.31.31.7-1.31.8-1.81.81.61.71.4-1.51.71.71.5-0.4-1.31.3
Delay disc. indifference point, 4s delay1.31.43.2-1.3-1.00.50.51.1-0.01.1-1.21.11.41.51.8-1.61.11.10.5-1.6-1.61.1
Delay disc. indifference point, 8s delay1.32.26.1-2.5-1.81.51.51.7-0.91.6-1.71.61.81.82.1-1.51.21.20.4-0.5-1.20.2
Indifference point function ln k2.16.38.42.32.9-2.5-2.5-2.92.0-2.92.9-2.9-2.9-2.6-2.32.8-2.7-2.7-2.50.11.7-2.2
Indifference point function log k2.16.38.42.32.9-2.5-2.5-2.92.0-2.92.9-2.9-2.9-2.6-2.32.8-2.7-2.7-2.50.11.7-2.2
Patch foraging total patch changes 0 sec0.30.73.5-1.1-0.91.11.10.8-1.90.9-0.80.80.20.2-0.1-0.60.50.50.91.20.60.6
Patch foraging total patch changes 12 sec4.76.38.8-2.8-3.02.52.52.9-2.12.9-2.92.93.02.42.1-2.82.72.72.50.2-1.31.9
Patch foraging total patch changes 18 sec0.92.03.3-1.8-1.61.01.01.6-1.21.6-1.71.71.41.51.5-1.81.41.41.3-0.3-0.91.1
Patch foraging total patch changes 24 sec0.31.04.5-1.0-1.11.01.01.1-2.11.2-1.11.10.70.50.1-1.10.40.41.31.00.21.0
Patch foraging total patch changes 6 sec3.86.49.7-2.1-3.02.52.53.0-2.93.1-3.13.12.52.31.6-2.82.22.22.90.7-1.12.5
Patch foraging time to switch 0 sec0.41.42.9-1.2-1.21.11.11.20.11.1-1.11.11.31.51.7-1.11.31.30.5-1.1-1.50.5
Patch foraging water rate 0 sec0.51.72.91.31.5-1.5-1.5-1.50.4-1.31.3-1.3-1.3-1.6-1.71.3-1.4-1.4-0.90.71.5-0.7
Patch foraging water rate 12 sec0.20.92.41.21.0-1.0-1.0-0.9-0.4-0.80.8-0.8-0.7-1.2-1.50.8-1.1-1.1-0.20.91.3-0.2
Patch foraging water rate 18 sec0.61.32.81.71.3-1.5-1.5-1.20.3-1.01.1-1.0-1.3-1.2-1.41.1-1.2-1.2-0.50.30.9-0.2
Patch foraging water rate 24 sec0.60.81.20.81.1-0.9-0.9-1.00.0-1.01.0-1.0-0.9-1.0-1.01.1-1.1-1.1-0.60.20.7-0.5
Patch foraging water rate 6 sec0.10.10.40.30.4-0.3-0.3-0.40.1-0.40.4-0.4-0.3-0.4-0.40.6-0.3-0.3-0.20.00.2-0.2
Seeking ratio, delayed vs. immediate footshock0.20.31.1-0.1-0.30.70.70.2-0.60.3-0.30.3-0.8-0.2-0.5-0.10.50.50.71.00.70.3
Distance traveled before self-admin0.10.31.20.80.7-1.1-1.1-0.40.4-0.20.2-0.2-0.8-0.1-0.2-0.2-0.5-0.50.0-0.7-0.20.6
Distance traveled after self-admin0.61.13.21.11.2-1.7-1.7-0.91.8-0.90.8-0.8-1.0-0.30.30.1-0.2-0.2-1.3-1.7-0.4-0.2
Extensor digitorum longus weight0.31.22.91.31.1-1.1-1.1-1.10.1-1.11.1-1.1-1.7-1.2-1.21.0-1.3-1.3-0.60.71.0-0.7
Bone: elastic displacement0.30.42.2-0.50.1-0.1-0.1-0.41.5-0.50.4-0.50.1-0.10.60.1-0.6-0.6-1.1-0.50.2-1.5
Bone: elastic work0.50.63.10.30.7-0.9-0.9-0.71.7-0.80.7-0.7-0.0-0.20.50.4-0.5-0.5-1.3-1.0-0.0-1.1
Bone: endosteal estimation3.17.715.74.03.5-3.4-3.4-3.21.8-3.13.0-3.0-2.9-2.6-2.42.4-2.8-2.8-2.6-0.61.4-1.5
Bone: endosteal perimeter2.76.611.13.13.3-3.2-3.2-3.11.7-3.03.0-2.9-3.0-2.5-2.12.3-2.4-2.4-2.3-0.81.2-1.3
Epididymis fat weight1.05.18.41.02.2-1.0-1.0-2.61.7-2.72.7-2.8-2.6-2.5-1.72.5-2.6-2.6-2.90.72.0-2.9
Delta time in closed arm before/after self-admin0.40.31.6-0.1-0.30.90.90.1-1.20.1-0.00.00.2-0.3-0.60.5-0.2-0.2-0.01.30.7-0.5
Delta time in open arm before/after self-admin0.91.06.50.40.6-1.4-1.4-0.21.4-0.20.0-0.00.30.60.9-0.70.70.7-0.0-2.5-1.61.2
Diff in mean of infusions in LGA sessions0.61.12.91.71.3-1.4-1.4-1.10.6-1.01.0-1.0-0.6-0.9-0.90.9-1.3-1.3-0.9-0.30.5-0.4
Delay discount exponential model param0.91.33.01.31.1-0.6-0.6-1.20.3-1.21.2-1.2-1.3-1.5-1.71.3-1.1-1.1-0.41.11.4-0.6
Extinction: sum of active levers before priming0.20.32.21.20.10.30.3-0.1-1.50.00.1-0.0-0.5-0.4-0.80.3-0.1-0.10.40.90.50.5
Active lever presses in extinction session 61.81.87.90.91.4-2.3-2.3-1.01.9-1.00.9-0.8-0.30.20.70.3-0.1-0.1-1.5-2.8-1.60.0
Bone: final force0.10.21.41.20.3-0.0-0.0-0.1-1.1-0.10.1-0.1-0.6-0.3-0.60.5-0.1-0.10.50.30.10.7
Bone: final moment0.20.31.31.20.4-0.0-0.0-0.4-1.0-0.30.4-0.4-0.9-0.5-0.80.7-0.5-0.50.10.50.50.2
Food consumed during 24 hour testing period0.10.30.70.6-0.50.60.60.5-0.90.6-0.60.60.50.3-0.2-0.10.20.20.70.70.10.3
Glucose0.20.41.40.60.5-0.1-0.1-0.5-0.5-0.40.5-0.4-0.5-0.8-1.20.6-0.8-0.80.20.90.8-0.0
Heart weight0.91.46.20.60.20.90.9-0.5-1.1-0.50.6-0.7-1.5-1.4-1.71.0-1.2-1.20.02.52.1-1.0
Delay discount hyperbolic model param0.70.92.51.30.9-0.5-0.5-1.00.1-0.91.0-1.0-1.0-1.3-1.61.1-0.9-0.9-0.11.11.2-0.4
Intermittent access intake day 1-15 change0.31.43.82.01.6-1.6-1.6-1.20.7-1.01.0-1.0-1.6-1.1-1.41.0-1.3-1.3-0.1-0.20.60.4
Intermittent access intake escalation0.42.14.82.21.9-2.1-2.1-1.51.1-1.41.3-1.3-1.8-1.4-1.51.2-1.5-1.5-0.5-0.30.80.2
Intermittent access intake escalation 21.42.46.82.22.1-2.6-2.6-1.61.4-1.41.3-1.3-1.6-1.2-1.31.0-1.6-1.6-0.5-0.90.40.4
Intermitt. access day 1 inactive lever presses0.00.21.2-0.10.3-0.6-0.6-0.31.1-0.30.2-0.20.10.10.30.2-0.0-0.0-0.5-0.8-0.3-0.3
Intermitt. access day 15 inactive lever presses0.21.02.71.60.9-0.8-0.8-1.01.4-0.90.9-0.9-0.3-1.0-0.90.6-0.9-0.9-1.20.41.1-1.3
Intermitt. access escalation Index0.31.02.1-0.30.7-0.8-0.8-0.91.0-0.91.0-1.0-0.7-1.1-1.01.0-1.2-1.2-0.70.81.3-1.5
Intermittent access day 1 total infusions0.10.31.91.40.3-0.5-0.5-0.21.2-0.10.1-0.10.40.10.10.10.30.3-0.3-0.6-0.3-0.1
Intermittent access day 15 total infusions0.81.97.62.71.7-1.5-1.5-1.41.3-1.21.3-1.2-1.3-1.4-1.81.4-1.1-1.1-0.30.31.1-0.1
Intermittent access terminal intake (last 3 days)0.81.36.52.51.4-1.6-1.6-1.11.6-0.90.9-0.8-0.7-0.9-1.31.0-0.9-0.9-0.3-0.10.6-0.0
Intermittent access total infusions0.60.73.81.90.9-0.9-0.9-0.81.3-0.60.7-0.6-0.3-0.6-0.90.8-0.5-0.5-0.50.10.5-0.4
Intermittent access day 1 locomotion0.20.31.41.20.6-0.2-0.2-0.51.1-0.60.6-0.5-0.4-0.3-0.30.50.20.2-0.4-0.4-0.1-0.3
Intermittent access day 15 total locomotion0.10.51.00.6-0.4-0.0-0.00.60.20.7-0.70.70.90.90.6-0.60.90.90.8-0.7-1.00.9
Intermittent access total locomotion0.30.41.51.20.2-0.5-0.50.01.00.1-0.10.10.40.60.6-0.30.60.6-0.1-1.2-1.10.3
Intermittent access standard deviation0.31.48.62.91.4-1.6-1.6-0.90.9-0.60.7-0.6-0.7-0.8-1.40.7-1.1-1.10.3-0.40.21.2
Left kidney weight0.10.51.80.5-0.51.01.00.5-1.30.6-0.50.5-0.1-0.1-0.6-0.4-0.0-0.01.11.40.60.6
Right kidney weight0.21.75.9-0.1-1.42.12.11.2-2.41.3-1.11.20.40.3-0.4-0.70.50.51.72.00.60.9
Cocaine induced anxiety0.61.72.70.11.5-1.5-1.5-1.51.7-1.51.5-1.5-1.3-1.1-0.61.2-1.1-1.1-1.6-0.60.5-1.5
Post-drug Anxiety1.31.54.0-0.90.8-0.1-0.1-1.20.1-1.31.3-1.4-1.5-1.4-1.01.4-1.5-1.5-1.31.11.4-2.0
Baseline Anxiety0.50.83.7-0.5-0.61.41.40.3-1.90.2-0.10.1-0.2-0.4-0.60.3-0.3-0.30.31.91.0-0.4
Tail length0.20.93.60.90.30.20.2-0.3-1.9-0.20.3-0.2-1.0-1.1-1.40.6-0.6-0.60.41.81.70.1
Length with tail0.20.94.21.3-0.10.30.30.1-2.10.3-0.20.2-0.7-0.7-1.30.4-0.4-0.41.01.91.40.6
Length without tail0.10.43.11.80.5-0.8-0.8-0.4-0.5-0.30.4-0.3-0.6-0.5-0.80.7-0.6-0.60.00.40.30.2
Times rat made contact with spout0.20.31.4-0.10.2-1.0-1.0-0.20.6-0.10.1-0.10.40.30.7-0.20.30.3-0.7-1.2-0.5-0.3
Lifetime Intake0.40.43.01.70.7-0.6-0.6-0.61.3-0.50.5-0.5-0.2-0.4-0.50.6-0.2-0.2-0.5-0.00.3-0.4
Liver weight, left0.20.31.70.1-0.30.80.80.2-1.30.2-0.10.2-0.5-0.2-0.70.2-0.2-0.20.91.10.50.4
Liver weight, right0.30.61.11.00.9-0.7-0.7-0.90.1-0.80.8-0.8-1.1-0.9-0.90.9-0.9-0.9-0.50.20.6-0.2
Locomotor activity0.00.10.20.20.3-0.3-0.3-0.20.5-0.20.1-0.1-0.3-0.2-0.0-0.0-0.1-0.1-0.2-0.10.4-0.2
Locomotor testing distance0.00.10.4-0.1-0.0-0.3-0.30.10.30.3-0.30.30.30.00.2-0.60.30.30.2-0.20.20.4
Locomotor testing rearing0.10.41.70.90.9-1.3-1.3-0.60.9-0.50.4-0.4-0.5-0.5-0.3-0.2-0.3-0.3-0.2-0.60.20.4
Locomotion in novel chamber2.12.96.91.82.2-2.0-2.0-2.02.6-2.02.0-1.9-1.4-1.1-0.61.3-1.1-1.1-2.0-1.6-0.1-1.0
Locomotion in novel chamber post-restriction0.30.92.70.5-0.60.60.60.8-0.60.8-0.80.80.61.00.7-1.01.41.40.9-0.6-1.31.7
Fecal boli incidents, locomotor time 10.20.51.70.70.7-1.3-1.3-0.61.2-0.50.5-0.5-0.5-0.20.00.50.10.1-1.0-0.6-0.1-0.7
Change in fecal boli incidents, locomotor task0.80.92.0-0.7-0.91.41.40.9-1.30.9-0.90.91.00.50.2-1.00.70.71.30.4-0.21.2
Time >=10cm from walls, locomotor time 10.81.03.61.7-0.10.30.30.4-1.90.7-0.50.60.1-0.2-1.4-0.1-0.0-0.01.91.20.41.8
Bouts of movement, locomotor time 10.20.30.7-0.5-0.70.30.30.6-0.20.6-0.60.60.60.70.9-0.70.50.5-0.0-0.3-0.5-0.2
Total resting periods, locomotor time 10.70.81.5-0.6-1.00.40.41.0-0.31.0-1.01.11.11.21.2-1.20.90.90.4-0.5-1.00.4
Rest time, locomotor task time 10.40.72.1-0.6-0.5-0.2-0.20.51.00.5-0.60.60.81.01.4-1.20.70.7-0.4-1.4-1.20.2
Distance moved, locomotor task time 10.30.72.90.6-0.01.01.00.0-1.70.00.0-0.0-0.1-0.8-1.40.3-0.5-0.51.01.61.20.7
Vertical activity count, locomotor time 10.10.52.00.0-0.10.80.80.1-1.40.1-0.00.0-0.6-0.5-1.10.4-0.2-0.21.11.30.70.6
Time >=10cm from walls, locomotor time 20.10.31.20.7-0.1-0.3-0.30.3-0.80.6-0.50.50.60.0-0.6-0.3-0.1-0.11.10.40.21.1
Bouts of movement, locomotor time 21.23.96.0-1.9-2.01.11.12.2-0.72.2-2.32.32.22.42.5-2.22.32.31.6-1.4-2.01.8
Total resting periods, locomotor time 21.14.46.3-1.9-2.11.11.12.3-0.92.4-2.52.42.32.52.5-2.42.42.41.7-1.5-2.12.1
Rest time, locomotor task time 21.11.84.0-1.4-1.20.30.31.3-0.41.3-1.41.41.31.61.8-2.01.61.60.7-1.3-1.81.3
Distance moved, locomotor task time 21.41.94.51.71.2-0.2-0.2-1.2-0.2-1.21.3-1.2-0.8-1.8-2.11.6-1.9-1.9-0.51.62.0-0.9
Vertical activity count, locomotor time 20.20.51.40.80.7-0.0-0.0-0.6-0.0-0.60.6-0.6-0.9-0.9-1.21.1-0.9-0.9-0.10.81.0-0.5
Light reinforcement 10.10.41.2-1.0-0.80.50.50.60.50.5-0.50.50.90.71.1-0.80.80.8-0.2-0.3-0.5-0.3
Light reinforcement 20.81.95.2-1.9-1.60.80.81.41.11.2-1.31.31.81.82.3-1.51.21.2-0.3-0.9-1.5-0.5
Bone: marrow area3.27.815.94.03.5-3.5-3.5-3.22.0-3.13.1-3.0-2.9-2.6-2.32.5-2.8-2.8-2.6-0.71.3-1.5
Bone: maximum diameter3.97.912.03.43.5-3.4-3.4-3.31.9-3.23.2-3.1-3.3-3.0-2.52.7-2.5-2.5-2.5-0.11.9-1.8
Bone: maximum force0.30.74.22.01.0-1.0-1.0-0.80.3-0.70.8-0.7-0.7-0.6-0.60.8-0.4-0.4-0.5-0.50.00.1
Bone: maximum moment0.50.94.02.01.1-1.0-1.0-1.10.2-1.01.0-1.0-1.0-0.8-0.81.0-0.9-0.9-0.8-0.20.4-0.4
Mean time between licks in bursts0.10.53.1-0.2-0.10.80.8-0.0-1.1-0.00.1-0.1-0.6-0.8-1.10.4-0.3-0.30.51.81.4-0.2
Mean num. licks in bursts1.02.74.01.82.0-1.7-1.7-1.90.8-1.81.9-1.8-1.9-1.9-2.01.7-1.7-1.7-1.10.51.4-0.9
Cd content in liver0.70.81.6-0.8-1.21.31.31.0-0.81.1-1.01.00.70.60.3-0.90.70.70.91.00.20.1
Co content in liver1.11.38.0-0.9-0.71.41.40.2-1.30.1-0.0-0.0-0.7-0.9-1.00.5-0.4-0.40.12.82.2-1.5
Cu content in liver5.66.79.0-2.7-2.92.02.03.0-1.12.9-3.02.92.73.02.9-3.02.82.82.3-1.1-2.42.1
Fe content in liver2.12.53.6-1.6-1.91.91.91.9-1.11.9-1.91.91.51.71.4-1.61.41.41.7-0.0-1.21.3
K content in liver1.61.64.4-0.5-0.7-0.0-0.01.10.01.1-1.21.21.21.61.5-1.41.41.41.1-1.8-2.11.9
Mg content in liver1.21.43.9-0.8-0.80.10.11.1-0.11.1-1.11.11.41.51.4-1.31.11.11.0-1.5-2.01.6
Mn content in liver4.95.511.9-2.1-2.10.90.92.30.32.2-2.32.32.93.13.2-2.42.82.81.4-2.5-3.41.9
Na content in liver1.92.24.0-0.7-1.40.90.91.6-0.31.6-1.61.61.41.91.6-1.71.71.71.4-1.1-2.01.6
Rb content in liver0.20.20.90.60.3-0.5-0.5-0.2-0.1-0.10.2-0.2-0.0-0.4-0.60.3-0.9-0.9-0.00.50.5-0.1
Se content in liver19.423.030.8-5.3-5.54.74.75.5-2.85.4-5.55.45.15.55.0-5.05.05.04.3-1.3-4.33.6
Sr content in liver0.70.61.3-0.1-0.70.60.60.9-0.20.9-0.90.90.80.80.6-0.91.11.11.1-0.3-0.71.0
Zn content in liver2.22.53.7-1.5-1.81.31.31.9-0.71.8-1.91.81.61.91.8-1.81.61.61.4-0.8-1.61.3
Bone: minimum diameter5.911.421.24.64.0-3.3-3.3-3.91.3-3.73.7-3.7-3.9-3.9-3.93.5-3.3-3.3-2.41.03.1-1.9
Time in familiar zone, hab. session 10.40.51.70.00.5-0.3-0.3-0.61.3-0.80.7-0.7-0.8-0.30.40.7-0.4-0.4-1.2-0.6-0.0-1.2
Time in novel zone, hab. session 10.70.71.7-0.3-0.70.40.40.9-0.91.0-1.01.01.20.70.3-1.11.01.01.2-0.0-0.41.3
Total zone transitions, hab. session 10.30.41.2-0.1-0.3-0.2-0.20.50.10.5-0.60.61.00.80.8-0.90.70.70.3-1.0-1.10.9
Total locomotion distance, hab. session 11.41.93.7-1.5-1.61.11.11.5-0.81.5-1.51.51.91.81.8-1.51.31.30.7-0.8-1.60.9
Locomotion velocity, hab. session 12.23.15.4-1.9-2.11.61.62.0-1.32.0-2.01.92.32.12.0-1.91.61.61.1-0.5-1.71.1
Time in familiar zone, hab. session 20.40.52.0-0.7-0.10.50.5-0.3-0.2-0.30.4-0.4-0.4-0.7-0.40.3-0.4-0.4-0.61.41.4-1.4
Time in novel zone, hab. session 20.20.20.80.4-0.2-0.1-0.10.4-0.00.5-0.50.50.60.60.3-0.40.40.40.6-0.6-0.80.9
Total zone transitions, hab. session 20.60.81.7-0.6-1.00.70.71.0-1.00.9-0.90.91.30.80.7-1.20.90.90.70.1-0.60.8
Total locomotion distance, hab. session 20.60.81.9-0.8-1.31.21.21.0-1.30.9-0.90.91.40.80.8-0.80.60.60.40.6-0.3-0.0
Locomotion velocity, hab. session 20.91.22.5-1.2-1.41.21.21.2-1.21.1-1.11.11.61.21.2-1.10.90.90.50.1-0.80.4
Novel to familiar place preference ratio1.41.98.91.11.2-2.5-2.5-0.72.2-0.60.4-0.40.50.40.8-0.20.20.2-0.9-3.0-1.70.6
Novelty place preference1.52.09.41.11.3-2.6-2.6-0.72.3-0.60.4-0.40.50.40.8-0.20.20.2-0.9-3.1-1.70.6
Time in novel zone, NPP test1.61.98.41.21.3-2.6-2.6-0.82.2-0.70.5-0.50.50.30.7-0.10.10.1-1.0-2.9-1.50.5
Total zone transitions, NPP test0.50.82.4-0.7-1.11.11.11.0-1.51.0-0.90.91.10.70.4-0.90.50.50.90.5-0.40.7
Total locomotion distance, NPP test1.82.54.4-1.6-2.01.71.71.9-1.81.8-1.81.82.11.71.5-1.61.31.31.20.1-1.20.9
Locomotion velocity, NPP test1.72.53.8-1.5-1.91.71.71.8-1.91.8-1.81.81.91.71.4-1.61.31.31.30.1-1.21.1
Intraocular pressure0.10.20.6-0.7-0.60.70.70.40.00.3-0.30.20.50.40.8-0.40.30.3-0.4-0.1-0.2-0.5
Delta distance traveled before/after self-admin1.01.12.40.81.3-1.2-1.2-1.21.5-1.31.3-1.3-0.8-0.8-0.20.8-0.5-0.5-1.5-0.90.2-1.0
Delta ambulatory time before/after self-admin1.12.03.51.11.7-1.5-1.5-1.71.9-1.81.7-1.7-1.1-1.3-0.71.3-1.0-1.0-1.8-0.60.6-1.4
Parametrial fat weight0.41.03.7-0.5-0.91.41.40.8-1.90.8-0.70.7-0.4-0.0-0.5-0.10.20.21.51.80.90.4
Pavlov. Cond. lever latency0.10.21.0-0.50.2-0.1-0.1-0.30.5-0.40.4-0.4-0.6-0.4-0.10.3-0.1-0.1-0.50.30.6-1.0
Pavlov. Cond. magazine entry latency0.70.83.00.5-0.91.11.10.9-1.71.1-1.01.00.60.4-0.4-0.40.40.41.51.10.11.1
Pavlov. Cond. change in total contacts0.20.21.21.1-0.10.20.20.2-0.70.3-0.20.20.1-0.1-0.80.2-0.3-0.30.70.80.40.5
Pavlov. Cond. index score0.60.82.00.4-0.80.80.81.0-1.21.1-1.01.11.00.80.1-0.80.70.71.30.2-0.51.4
Pavlov. Cond. latency score0.50.61.70.4-0.70.70.70.8-1.20.9-0.90.90.90.60.1-0.70.50.51.10.2-0.41.3
Pavlov. Cond. lever contacts0.40.51.10.1-0.70.80.80.8-1.10.8-0.80.80.90.70.3-0.70.50.50.8-0.0-0.71.1
Pavlov. Cond. magazine entry number0.20.20.7-0.80.2-0.5-0.5-0.20.8-0.30.2-0.2-0.10.10.7-0.30.30.3-0.5-0.9-0.4-0.3
Pavlov. Cond. intertrial magazine entries0.00.00.3-0.1-0.20.20.20.1-0.50.1-0.10.10.10.10.1-0.0-0.3-0.30.00.2-0.0-0.2
Pavlov. Cond. lever-magazine prob. diff.0.60.71.70.3-0.80.80.80.9-1.11.0-1.01.01.00.70.1-0.70.70.71.20.2-0.51.3
Pavlov. Cond. response bias0.20.31.10.7-0.40.60.60.5-1.10.6-0.50.50.50.3-0.4-0.0-0.0-0.00.80.6-0.10.7
Pavlov. Cond. lever latency0.81.13.31.21.3-1.2-1.2-1.21.8-1.21.2-1.2-0.8-0.9-0.51.0-0.6-0.6-1.3-0.60.3-0.8
Pavlov. Cond. magazine entry latency0.20.31.50.3-0.40.40.40.3-1.20.4-0.30.30.50.1-0.50.5-0.6-0.60.60.90.4-0.1
Pavlov. Cond. change in total contacts0.20.42.6-0.7-0.70.90.90.6-1.60.6-0.60.60.20.3-0.0-0.30.00.00.80.70.20.4
Pavlov. Cond. index score0.50.73.4-0.5-1.00.90.91.0-1.91.0-1.01.00.70.60.1-0.50.10.11.20.8-0.00.6
Pavlov. Cond. latency score0.30.62.8-0.3-0.80.70.70.8-1.70.9-0.90.90.70.5-0.0-0.3-0.0-0.01.10.7-0.00.5
Pavlov. Cond. lever contacts0.81.24.1-1.3-1.41.31.31.2-2.01.3-1.21.20.70.80.5-0.90.50.51.30.9-0.10.7
Pavlov. Cond. magazine entry number1.01.45.50.61.4-1.5-1.5-1.32.3-1.41.3-1.3-1.2-0.80.00.3-0.1-0.1-1.5-1.3-0.1-0.6
Pavlov. Cond. intertrial magazine entries0.61.22.60.91.3-1.2-1.2-1.31.6-1.31.3-1.3-1.3-0.9-0.40.9-0.6-0.6-1.4-0.60.4-1.0
Pavlov. Cond. lever-magazine prob. diff.0.40.73.2-0.4-0.90.80.80.9-1.81.0-1.01.00.80.60.1-0.50.10.11.20.7-0.10.6
Pavlov. Cond. response bias0.81.14.3-1.0-1.31.21.21.2-2.11.2-1.21.10.70.70.2-0.60.30.31.31.00.00.6
Time in closed arm before self-admin0.20.41.70.40.6-1.2-1.2-0.51.3-0.40.4-0.4-0.1-0.10.40.1-0.1-0.1-0.9-0.9-0.1-0.6
Time in closed arm after self-admin0.10.20.6-0.8-0.20.30.3-0.1-0.6-0.10.1-0.1-0.1-0.20.20.3-0.2-0.2-0.60.50.5-0.8
Time in open arm before self-admin0.40.51.8-0.70.10.30.3-0.5-0.1-0.60.6-0.7-0.5-0.6-0.30.8-1.0-1.0-0.90.80.7-1.3
Time in open arm after self-admin0.60.72.9-0.3-0.1-0.4-0.40.40.40.4-0.50.50.70.91.0-1.00.90.90.5-1.7-1.41.2
Bone: periosteal estimation2.25.211.73.42.8-2.6-2.6-2.60.9-2.52.5-2.5-2.7-2.4-2.32.1-2.2-2.2-1.80.11.6-1.1
Bone: periosteal perimeter2.44.77.22.62.6-2.3-2.3-2.50.9-2.52.5-2.5-2.7-2.4-2.12.2-2.1-2.1-1.80.21.6-1.4
Bone: post-yield work0.61.04.12.01.3-1.3-1.3-1.10.2-1.11.1-1.0-0.8-0.9-0.91.1-0.8-0.8-0.9-0.40.3-0.3
Progressive ratio test 1 active lever presses0.10.31.01.0-0.0-0.2-0.20.20.70.3-0.30.30.30.50.4-0.40.70.70.2-0.7-0.70.6
Progressive ratio test 1 breakpoint0.20.30.70.9-0.2-0.0-0.00.40.50.4-0.40.50.40.60.5-0.60.80.80.4-0.7-0.80.8
Progressive ratio test 1 inactive lever presses0.20.52.71.60.7-1.1-1.1-0.51.4-0.40.4-0.40.4-0.2-0.00.3-0.1-0.1-0.7-0.8-0.1-0.3
Progressive ratio test 2 active lever presses0.50.74.22.00.8-1.4-1.4-0.51.2-0.30.3-0.30.4-0.1-0.20.3-0.0-0.0-0.5-1.0-0.30.0
Progressive ratio test 2 breakpoint0.50.74.42.10.8-1.5-1.5-0.61.2-0.40.3-0.30.4-0.1-0.20.3-0.1-0.1-0.5-0.9-0.2-0.1
Progressive ratio test 2 inactive lever presses0.20.62.91.40.5-1.1-1.1-0.21.7-0.10.1-0.00.80.30.4-0.10.30.3-0.6-1.4-0.70.0
Incentive Sensitization - Responses0.30.94.82.21.1-1.9-1.9-0.81.1-0.50.5-0.50.2-0.3-0.40.6-0.3-0.3-0.6-1.0-0.0-0.2
Incentive Sensitization - Breakpoint0.40.84.92.21.0-1.8-1.8-0.70.9-0.50.5-0.40.3-0.4-0.50.6-0.3-0.3-0.5-0.80.1-0.2
Sum of active levers in priming session hrs 5-60.10.10.2-0.5-0.30.50.50.2-0.40.1-0.10.1-0.00.10.3-0.0-0.1-0.1-0.20.10.1-0.3
Progressive ratio0.20.62.2-0.9-0.00.60.6-0.3-0.7-0.40.5-0.5-0.7-0.7-0.60.8-0.7-0.7-0.51.51.2-1.3
Food seeking constrained by brief footshock0.60.83.10.9-0.50.40.40.8-1.71.0-0.91.00.60.4-0.3-0.80.20.21.60.50.01.8
Seeking ratio, punishment vs. effort0.61.35.40.8-0.70.20.21.1-1.01.3-1.31.41.21.00.5-1.40.90.91.7-0.7-1.02.3
Retroperitoneal fat weight0.21.02.6-0.40.20.70.7-0.6-0.4-0.70.8-0.8-0.7-1.0-0.81.1-1.3-1.3-0.81.61.5-1.6
Reaction time number correct0.62.35.00.92.0-2.2-2.2-1.81.7-1.81.8-1.8-1.5-1.3-0.81.2-1.1-1.1-1.6-1.10.3-0.9
Reaction time mean minus median0.21.44.11.50.8-0.2-0.2-0.9-0.3-0.80.9-0.8-0.8-1.5-2.01.6-1.2-1.2-0.21.81.9-0.9
Reaction time mean minus median AUC0.21.43.40.80.8-0.2-0.2-0.9-0.2-0.91.0-1.0-1.0-1.4-1.81.7-1.4-1.4-0.51.71.8-1.3
Reaction time num false alarms0.10.21.80.1-0.10.50.50.1-1.30.1-0.10.1-0.4-0.3-0.5-0.10.10.10.60.90.60.4
Reaction time num false alarms AUC0.10.32.50.2-0.10.60.60.1-1.60.1-0.10.1-0.4-0.4-0.70.00.10.10.71.00.70.4
Reaction time trials correct on left0.62.35.00.92.0-2.2-2.2-1.81.7-1.81.8-1.8-1.5-1.3-0.81.2-1.1-1.1-1.6-1.10.3-0.9
Reaction time trials on left0.72.34.90.92.0-2.2-2.2-1.81.7-1.81.8-1.8-1.5-1.3-0.91.3-1.1-1.1-1.6-1.00.4-0.9
Reaction time mean0.40.94.50.4-0.71.41.40.5-1.60.6-0.50.50.1-0.3-1.00.4-0.2-0.20.82.11.3-0.2
Reaction time mean AUC0.40.93.60.1-0.91.61.60.7-1.70.8-0.70.70.3-0.0-0.70.20.00.01.11.91.00.1
Median of all reaction times0.50.83.10.1-0.91.51.50.7-1.50.8-0.70.70.30.1-0.50.00.10.10.91.80.9-0.1
Reaction time omissions1.42.35.31.21.1-0.5-0.5-1.30.1-1.21.3-1.3-1.3-1.9-2.31.9-1.7-1.7-0.62.22.3-1.7
Reaction time false alarm rate0.71.04.6-0.3-1.01.51.50.9-2.10.9-0.90.90.40.2-0.2-0.60.60.61.21.40.50.7
Reaction time premature initiation rate0.50.72.60.0-0.80.90.90.8-1.60.9-0.80.91.00.3-0.5-0.30.20.21.31.30.41.0
Reaction time premature initiations0.10.31.20.50.3-0.3-0.3-0.2-0.7-0.10.2-0.10.0-0.6-1.10.5-0.5-0.50.40.90.70.4
Std. dev. reaction times0.51.87.81.10.30.70.7-0.6-1.3-0.50.6-0.6-0.9-1.5-2.31.7-1.3-1.30.12.82.4-1.0
Reaction time trials completed0.72.34.90.92.0-2.2-2.2-1.81.7-1.81.8-1.8-1.5-1.3-0.91.3-1.1-1.1-1.6-1.00.4-0.9
Reaction time trials AUC0.62.14.60.71.9-2.1-2.1-1.71.6-1.81.7-1.7-1.4-1.2-0.71.2-1.0-1.0-1.5-1.00.3-0.9
Run reversals in cocaine runway, females0.60.72.0-0.6-0.80.30.30.8-0.30.8-0.90.81.01.11.4-0.90.80.80.1-1.1-1.10.4
Run reversals in cocaine runway, males2.52.74.3-1.4-2.01.71.72.0-2.02.0-2.02.01.41.50.9-1.71.31.32.10.7-0.81.7
Latency to leave start box in cocaine runway3.14.25.91.22.1-1.6-1.6-2.31.3-2.42.4-2.4-2.3-2.4-2.02.3-2.1-2.1-2.21.02.2-2.3
Latency to leave start box in cocaine runway, F3.34.15.71.52.3-2.0-2.0-2.41.6-2.42.4-2.4-2.3-2.3-1.82.0-2.1-2.1-2.00.31.8-1.7
Latency to leave start box in cocaine runway, M0.90.92.90.10.7-0.2-0.2-1.00.3-1.01.1-1.1-0.9-1.0-0.81.2-0.7-0.7-1.30.91.2-1.7
Std. dev. time between licks in bursts0.61.13.8-1.8-1.42.02.01.0-1.00.9-0.90.80.30.60.6-0.50.40.40.71.10.1-0.3
Total sessions with >9 infusions0.30.41.0-0.3-0.60.70.70.60.30.5-0.60.50.50.70.9-0.71.01.00.4-0.6-0.70.6
Short access day 1 total inactive lever presses1.02.010.30.91.3-1.8-1.8-1.33.2-1.41.3-1.3-0.5-0.40.60.7-0.3-0.3-2.0-1.9-0.5-1.4
Short access day 10 total inactive lever presses0.00.10.5-0.60.1-0.3-0.3-0.2-0.1-0.10.1-0.10.1-0.4-0.30.1-0.5-0.5-0.10.50.7-0.5
Short access day 1 total infusions0.40.81.7-0.4-0.90.70.70.80.80.8-0.80.81.31.11.3-0.91.31.30.1-0.8-1.10.2
Short access day 10 total infusions0.40.71.3-0.3-1.11.21.20.9-0.20.9-0.90.91.10.70.5-0.91.01.00.60.5-0.10.3
Short access total infusions0.20.21.20.7-0.1-0.1-0.10.21.10.2-0.20.20.60.40.5-0.40.60.6-0.2-0.6-0.50.1
Short access day 1 locomotion0.30.53.0-0.50.1-0.0-0.0-0.01.3-0.10.0-0.10.50.61.3-0.40.80.8-0.6-1.7-1.20.0
Short access day 10 total locomotion0.20.72.1-0.1-0.70.50.50.70.30.6-0.70.70.91.21.2-0.31.31.30.3-1.1-1.50.4
Short access total locomotion0.40.61.7-0.5-0.40.40.40.51.00.4-0.50.40.80.91.3-0.61.01.00.1-1.3-1.20.3
One hour access (0.3 mA shock)1.41.69.83.11.6-2.0-2.0-1.21.6-0.90.9-0.8-0.3-0.6-0.91.0-0.6-0.6-0.6-1.0-0.10.1
Compulsive drug intake1.21.72.51.21.4-1.4-1.4-1.41.2-1.31.4-1.4-0.9-1.6-1.61.5-1.5-1.5-0.70.61.5-1.1
One hour access (shock baseline)0.10.11.61.30.2-0.1-0.1-0.0-0.10.1-0.10.1-0.10.2-0.2-0.00.40.40.3-0.4-0.40.6
Social response proportion1.62.16.01.41.8-1.9-1.9-1.62.4-1.71.6-1.6-1.1-0.8-0.31.2-0.9-0.9-1.5-1.6-0.3-0.8
Social responses0.30.51.20.70.9-0.8-0.8-0.81.1-0.90.8-0.8-0.5-0.5-0.20.5-0.3-0.3-0.6-0.8-0.1-0.1
Social time0.40.62.2-0.5-0.60.70.70.7-0.80.7-0.70.70.30.70.5-1.00.80.81.2-0.5-0.91.5
Soleus weight1.44.15.62.02.3-2.0-2.0-2.31.2-2.32.3-2.3-2.2-2.0-1.62.4-2.2-2.2-2.10.11.3-2.0
Bone: stiffness0.40.84.92.21.1-1.1-1.1-0.9-0.1-0.80.8-0.8-0.9-0.8-1.10.8-0.4-0.4-0.3-0.00.40.3
Tibialis anterior weight0.51.62.81.71.5-1.7-1.7-1.40.7-1.41.4-1.3-1.5-1.2-0.91.3-1.2-1.2-1.1-0.30.5-0.6
Time to tail flick, vehicle, before self-admin1.11.34.4-1.5-0.90.20.20.91.00.7-0.90.80.91.52.1-1.41.21.2-0.2-1.8-1.70.2
Time to tail flick, vehicle, after self-admin0.10.20.80.20.5-0.7-0.7-0.4-0.9-0.30.3-0.3-0.1-0.2-0.1-0.2-0.4-0.4-0.1-0.6-0.20.5
Time to tail flick, test, before self-admin0.40.42.21.50.8-0.9-0.9-0.60.9-0.60.6-0.5-0.1-0.2-0.20.4-0.2-0.2-0.7-0.7-0.2-0.2
Time to tail flick, test, after self-admin0.30.31.0-0.90.0-0.5-0.5-0.10.8-0.10.0-0.10.30.30.90.1-0.2-0.2-0.8-1.0-0.3-0.7
Delta time to tail flick, vehicle, before/after SA0.70.71.51.21.0-1.0-1.0-0.9-1.0-0.70.8-0.7-0.5-0.9-1.20.8-1.0-1.0-0.10.20.60.3
Delta time to tail flick, test, before/after SA0.20.21.7-1.3-0.50.20.20.40.00.4-0.50.40.60.50.9-0.40.20.2-0.0-0.3-0.1-0.3
Tibia length0.10.31.2-0.2-0.40.60.60.3-1.00.4-0.30.30.0-0.2-0.50.00.30.30.71.10.70.3
Ambulatory time before self-admin0.10.31.10.60.6-1.0-1.0-0.30.5-0.20.1-0.1-0.9-0.1-0.0-0.2-0.3-0.3-0.0-0.7-0.20.5
Ambulatory time after self-admin1.42.36.71.71.8-2.5-2.5-1.42.6-1.41.2-1.2-1.3-0.60.10.5-0.6-0.6-1.6-2.1-0.5-0.3
Bone: tissue strength0.40.40.90.50.5-0.1-0.1-0.6-0.4-0.60.6-0.6-0.5-0.7-0.91.0-0.9-0.9-0.40.60.7-0.5
Total heroin consumption0.10.21.00.3-0.30.10.10.3-1.00.4-0.40.40.30.40.3-0.30.60.60.1-0.2-0.40.4
Bone: trabecular number1.22.24.11.91.8-2.0-2.0-1.72.0-1.61.5-1.5-1.3-1.1-0.71.1-1.4-1.4-1.7-0.90.5-1.0
Bone: trabecular spacing0.60.92.8-0.9-1.01.51.50.8-1.70.9-0.80.80.60.1-0.4-0.10.40.41.01.60.80.2
Bone: trabecular thickness1.52.13.11.61.8-1.7-1.7-1.71.0-1.61.6-1.6-1.4-1.5-1.31.2-1.5-1.5-1.3-0.11.1-1.0
Bone: trabecular tissue density0.40.61.61.01.0-1.3-1.3-0.90.9-0.90.9-0.9-0.6-0.8-0.50.4-0.4-0.4-0.6-0.30.3-0.3
Water consumed over 24 hours0.20.42.20.90.4-1.1-1.1-0.10.90.0-0.10.10.50.50.6-0.30.30.3-0.5-1.5-0.80.3
Number of responses in last shaping day0.10.11.2-0.6-0.20.50.5-0.01.1-0.10.1-0.10.3-0.00.3-0.00.10.1-0.10.00.2-0.7