Hub : Genes

Pkdrej

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Pkdrej 0.03 0.03 4.7e-03 0.03 0.02 0.02 0.02 6.9e-04 6.3e-03 2.4e-03 2.3e-03
2 PL gene expression Pkdrej 0.04 0.03 2.2e-03 0.01 0.02 0.01 0.02 3.7e-02 3.3e-03 3.2e-02 6.1e-03
3 Adipose gene expression Pkdrej 0.08 0.04 5.2e-07 0.04 0.06 0.07 0.06 9.9e-06 1.3e-07 5.5e-08 1.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.50.91.51.2-0.80.8
Area under the delay curve1.11.72.51.6-1.21.0
BMI with tail0.20.71.9-1.4-0.50.1
BMI without tail0.10.40.8-0.90.1-0.5
Body weight0.83.46.3-2.51.2-1.6
Weight adjusted by age0.31.01.9-1.40.6-0.9
Bone surface0.10.20.50.7-0.40.3
Bone volume0.20.30.70.8-0.40.4
Breakpoint value in progressive ratio session1.01.72.41.2-1.21.6
Number of licking bursts0.10.40.7-0.00.8-0.8
Context. condit. distance diff. score0.60.71.4-1.20.6-0.5
Locomotion velocity, session 13.43.84.4-2.01.7-2.1
Locomotion distance, session 10.60.81.2-0.70.9-1.1
Locomotion velocity, session 23.84.65.9-2.41.8-2.1
Locomotion distance, session 20.30.40.70.4-0.80.6
Locomotion velocity, session 37.08.08.9-2.63.0-2.9
Locomotion distance, session 31.61.82.7-0.91.6-1.4
Stereotopy head waving bouts, day 30.70.81.5-1.20.4-0.9
Stereotopy head waving duration, day 31.31.63.4-1.90.5-1.1
Locomotion velocity, session 72.32.53.0-1.71.5-1.5
Locomotion distance, session 70.50.70.9-0.70.9-0.8
Stereotopy head waving bouts, day 71.51.82.1-1.51.3-1.3
Stereotopy head waving duration, day 70.70.81.1-1.10.8-0.9
Locomotion velocity, session 81.61.94.2-2.00.8-0.9
Locomotion distance, session 80.71.01.5-1.20.9-0.9
Degree of sensitization distance0.30.30.50.0-0.60.7
Degree of sensitization stereotypy0.60.70.8-0.90.8-0.7
Conditioned locomotion0.10.10.1-0.40.1-0.2
Cocaine response after cond. corrected0.61.01.4-0.90.9-1.2
Cocaine response after cond. not corrected1.21.72.5-1.01.2-1.6
Cocaine response before conditioning0.10.10.10.10.4-0.3
Saline control response0.00.00.10.20.30.1
Bone: connectivity density0.10.10.30.5-0.10.1
Bone: cortical apparent density0.50.81.31.1-0.70.8
Bone: cortical area0.10.20.6-0.80.2-0.1
Bone: cortical porosity0.20.20.50.1-0.20.7
Bone: cortical porosity0.10.20.40.0-0.20.6
Bone: cortical thickness0.40.60.90.6-0.70.9
Bone: cortical thickness0.40.50.8-0.1-0.80.9
Bone: cortical tissue density0.40.61.01.0-0.60.7
Condit. Reinf. active minus inactive responses0.20.30.50.7-0.20.4
Condit. Reinf. active-inactive response ratio0.80.81.51.2-0.60.8
Condit. Reinf. active responses0.10.10.20.40.3-0.3
Condit. Reinf. inactive responses0.60.71.0-0.41.0-1.0
Incentive salience index mean0.50.61.0-0.51.0-0.8
Condit. Reinf. lever presses2.74.14.5-1.92.1-2.1
Condit. Reinf. active minus inactive responses0.10.20.30.4-0.40.6
Condit. Reinf. active-inactive response ratio0.00.10.10.3-0.20.3
Condit. Reinf. active responses0.10.10.1-0.3-0.30.3
Condit. Reinf. inactive responses0.30.51.4-1.20.1-0.3
Condit. Reinf. lever presses0.10.10.3-0.6-0.0-0.2
Condit. Reinf. lever reinforcers received0.10.10.2-0.1-0.40.4
Conditioned reinforcement - actives0.00.10.20.00.40.0
Conditioned reinforcement - inactives0.00.10.10.10.20.3
Conditioned locomotion2.03.03.6-1.91.5-1.7
Patch foraging indifference point 0 sec0.00.10.30.5-0.20.2
Patch foraging indifference point AUC0.10.10.30.5-0.10.3
Delay disc. indifference point, 0s delay0.00.00.0-0.1-0.1-0.0
Delay disc. indifference point, 16s delay1.31.92.71.6-1.31.1
Delay disc. indifference point, 2s delay0.80.91.11.1-0.80.9
Delay disc. indifference point, 24s delay0.30.40.70.3-0.90.6
Delay disc. indifference point, 4s delay3.33.54.72.2-1.91.5
Delay disc. indifference point, 8s delay1.22.02.71.6-1.41.2
Indifference point function ln k0.92.83.7-1.91.5-1.5
Indifference point function log k0.92.83.7-1.91.5-1.5
Patch foraging total patch changes 0 sec0.10.20.40.6-0.20.2
Patch foraging total patch changes 12 sec0.00.10.10.3-0.20.2
Patch foraging total patch changes 18 sec0.10.10.30.60.2-0.2
Patch foraging total patch changes 24 sec0.00.10.2-0.30.4-0.5
Patch foraging total patch changes 6 sec0.40.71.01.0-0.90.7
Patch foraging time to switch 0 sec0.20.61.00.6-1.00.7
Patch foraging water rate 0 sec0.00.00.1-0.20.2-0.0
Patch foraging water rate 12 sec0.41.82.1-1.11.4-1.5
Patch foraging water rate 18 sec0.20.40.5-0.50.7-0.7
Patch foraging water rate 24 sec0.00.00.0-0.20.20.0
Patch foraging water rate 6 sec0.71.11.7-0.41.3-1.1
Seeking ratio, delayed vs. immediate footshock0.81.21.61.3-0.91.1
Distance traveled before self-admin0.61.32.0-0.81.4-1.2
Distance traveled after self-admin0.10.10.2-0.40.4-0.0
Extensor digitorum longus weight0.31.11.9-1.40.7-1.0
Bone: elastic displacement0.70.80.9-1.00.8-0.9
Bone: elastic work0.50.71.8-1.30.3-0.4
Bone: endosteal estimation0.82.13.8-2.01.0-1.2
Bone: endosteal perimeter1.33.25.1-2.31.5-1.5
Epididymis fat weight0.10.30.60.1-0.60.8
Delta time in closed arm before/after self-admin0.70.60.90.7-0.80.9
Delta time in open arm before/after self-admin3.13.74.4-1.52.1-2.1
Diff in mean of infusions in LGA sessions0.40.71.40.5-0.61.2
Delay discount exponential model param1.31.82.7-1.61.3-1.0
Extinction: sum of active levers before priming1.01.41.80.9-1.31.4
Active lever presses in extinction session 60.10.10.2-0.5-0.40.2
Bone: final force0.50.81.30.1-1.11.1
Bone: final moment0.71.11.70.0-1.31.2
Food consumed during 24 hour testing period0.81.52.9-1.71.0-0.9
Glucose0.10.20.30.50.10.5
Heart weight0.20.40.6-0.5-0.80.5
Delay discount hyperbolic model param1.41.92.9-1.71.3-1.0
Intermittent access intake day 1-15 change0.00.20.5-0.50.7-0.0
Intermittent access intake escalation0.00.30.7-0.30.8-0.2
Intermittent access intake escalation 20.20.30.50.5-0.00.7
Intermitt. access day 1 inactive lever presses0.11.21.81.0-0.91.4
Intermitt. access day 15 inactive lever presses0.00.20.5-0.0-0.00.7
Intermitt. access escalation Index0.00.10.20.4-0.20.4
Intermittent access day 1 total infusions1.64.75.1-2.22.2-2.0
Intermittent access day 15 total infusions1.64.06.2-1.72.5-1.7
Intermittent access terminal intake (last 3 days)2.34.05.6-2.02.4-1.6
Intermittent access total infusions3.03.64.9-1.82.2-1.6
Intermittent access day 1 locomotion1.73.13.9-1.52.0-1.8
Intermittent access day 15 total locomotion1.34.95.8-2.22.4-2.0
Intermittent access total locomotion3.13.84.5-2.02.1-1.7
Intermittent access standard deviation0.00.20.4-0.60.60.0
Left kidney weight2.217.336.6-6.02.5-3.0
Right kidney weight1.611.427.9-5.31.5-2.1
Cocaine induced anxiety0.30.91.40.5-1.21.1
Post-drug Anxiety3.33.84.31.8-1.92.1
Baseline Anxiety0.10.10.30.30.5-0.2
Tail length0.52.84.3-0.72.1-1.9
Length with tail1.14.85.3-1.92.3-2.3
Length without tail0.10.41.2-1.10.2-0.1
Times rat made contact with spout1.41.62.0-1.21.2-1.4
Lifetime Intake2.93.64.7-1.92.2-1.6
Liver weight, left2.23.84.6-2.21.8-1.9
Liver weight, right3.35.87.0-2.12.7-2.4
Locomotor activity3.55.56.7-2.62.1-2.4
Locomotor testing distance0.51.31.7-1.21.0-1.3
Locomotor testing rearing0.72.42.8-1.71.5-1.5
Locomotion in novel chamber3.44.66.1-1.82.2-2.5
Locomotion in novel chamber post-restriction0.00.10.20.2-0.50.2
Fecal boli incidents, locomotor time 10.00.00.1-0.30.2-0.0
Change in fecal boli incidents, locomotor task0.60.61.1-0.60.7-1.0
Time >=10cm from walls, locomotor time 10.10.10.3-0.3-0.50.0
Bouts of movement, locomotor time 10.00.00.1-0.2-0.10.2
Total resting periods, locomotor time 10.40.50.70.3-0.90.8
Rest time, locomotor task time 10.30.51.0-1.00.3-0.7
Distance moved, locomotor task time 10.00.00.00.1-0.00.2
Vertical activity count, locomotor time 10.10.80.90.9-0.80.9
Time >=10cm from walls, locomotor time 20.10.40.60.1-0.80.6
Bouts of movement, locomotor time 20.72.42.81.4-1.71.6
Total resting periods, locomotor time 20.62.42.71.4-1.71.6
Rest time, locomotor task time 20.61.01.9-0.31.0-1.4
Distance moved, locomotor task time 20.10.20.4-0.70.20.1
Vertical activity count, locomotor time 20.10.20.5-0.1-0.30.7
Light reinforcement 10.83.54.4-2.11.4-2.0
Light reinforcement 20.92.03.5-1.91.1-1.1
Bone: marrow area0.81.93.6-1.90.9-1.1
Bone: maximum diameter1.42.75.7-2.41.1-1.1
Bone: maximum force0.61.21.90.1-1.41.3
Bone: maximum moment0.71.42.30.0-1.51.4
Mean time between licks in bursts0.00.10.3-0.10.3-0.6
Mean num. licks in bursts0.10.20.6-0.8-0.0-0.1
Cd content in liver0.00.00.0-0.2-0.1-0.1
Co content in liver0.20.30.4-0.40.5-0.7
Cu content in liver4.85.77.42.7-2.32.1
Fe content in liver0.30.41.00.0-1.00.5
K content in liver0.10.10.10.1-0.20.3
Mg content in liver0.60.70.80.6-0.90.9
Mn content in liver1.92.22.7-1.41.6-1.4
Na content in liver1.51.72.11.4-1.21.3
Rb content in liver3.03.54.91.3-2.21.9
Se content in liver0.20.20.2-0.20.5-0.5
Sr content in liver0.40.30.6-0.10.8-0.6
Zn content in liver0.30.30.4-0.50.6-0.6
Bone: minimum diameter1.22.32.6-1.61.6-1.3
Time in familiar zone, hab. session 10.50.61.2-1.10.4-0.6
Time in novel zone, hab. session 10.20.20.20.5-0.30.4
Total zone transitions, hab. session 10.60.91.51.2-0.70.8
Total locomotion distance, hab. session 10.40.50.7-0.60.7-0.8
Locomotion velocity, hab. session 10.60.81.1-0.80.9-1.1
Time in familiar zone, hab. session 20.91.01.3-0.81.1-1.1
Time in novel zone, hab. session 21.01.11.21.1-1.01.1
Total zone transitions, hab. session 20.30.30.60.0-0.80.6
Total locomotion distance, hab. session 20.00.00.1-0.3-0.0-0.0
Locomotion velocity, hab. session 20.00.00.1-0.30.0-0.1
Novel to familiar place preference ratio0.00.00.1-0.10.1-0.3
Novelty place preference0.20.30.5-0.50.5-0.7
Time in novel zone, NPP test0.30.30.5-0.50.5-0.7
Total zone transitions, NPP test0.50.81.11.0-0.70.8
Total locomotion distance, NPP test0.00.00.10.2-0.10.1
Locomotion velocity, NPP test0.00.00.00.20.0-0.0
Intraocular pressure1.52.53.2-1.31.7-1.8
Delta distance traveled before/after self-admin0.10.10.3-0.60.1-0.1
Delta ambulatory time before/after self-admin0.00.10.1-0.4-0.10.2
Parametrial fat weight0.30.71.4-0.30.8-1.2
Pavlov. Cond. lever latency1.92.43.01.4-1.71.6
Pavlov. Cond. magazine entry latency0.10.20.30.6-0.10.4
Pavlov. Cond. change in total contacts0.10.10.10.2-0.20.3
Pavlov. Cond. index score0.10.10.2-0.10.4-0.1
Pavlov. Cond. latency score0.20.20.4-0.40.6-0.4
Pavlov. Cond. lever contacts1.82.22.9-1.31.7-1.5
Pavlov. Cond. magazine entry number0.10.20.4-0.60.0-0.4
Pavlov. Cond. intertrial magazine entries0.40.51.01.0-0.50.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.00.4-0.2
Pavlov. Cond. response bias0.30.40.7-0.30.8-0.5
Pavlov. Cond. lever latency0.10.10.2-0.00.4-0.4
Pavlov. Cond. magazine entry latency4.66.67.32.4-2.62.7
Pavlov. Cond. change in total contacts1.02.42.91.2-1.71.7
Pavlov. Cond. index score1.21.82.21.2-1.41.5
Pavlov. Cond. latency score1.32.12.51.1-1.51.6
Pavlov. Cond. lever contacts0.20.30.40.3-0.60.6
Pavlov. Cond. magazine entry number2.02.63.0-1.51.6-1.7
Pavlov. Cond. intertrial magazine entries0.10.30.4-0.0-0.60.7
Pavlov. Cond. lever-magazine prob. diff.1.01.61.81.1-1.31.4
Pavlov. Cond. response bias0.81.01.20.9-1.11.1
Time in closed arm before self-admin0.30.51.21.1-0.30.4
Time in closed arm after self-admin0.10.10.20.20.4-0.2
Time in open arm before self-admin0.10.10.1-0.40.1-0.3
Time in open arm after self-admin0.10.10.2-0.30.3-0.4
Bone: periosteal estimation0.61.53.1-1.80.8-0.8
Bone: periosteal perimeter2.14.25.9-2.41.9-1.7
Bone: post-yield work1.52.63.11.4-1.81.6
Progressive ratio test 1 active lever presses1.42.53.1-1.41.8-1.6
Progressive ratio test 1 breakpoint1.42.43.0-1.31.7-1.5
Progressive ratio test 1 inactive lever presses0.51.31.6-1.11.3-0.9
Progressive ratio test 2 active lever presses0.10.10.30.20.00.5
Progressive ratio test 2 breakpoint0.00.10.10.10.10.4
Progressive ratio test 2 inactive lever presses0.00.10.20.20.40.5
Incentive Sensitization - Responses0.41.11.90.9-0.81.4
Incentive Sensitization - Breakpoint0.41.01.70.8-0.81.3
Sum of active levers in priming session hrs 5-60.80.70.90.9-0.70.9
Progressive ratio0.10.20.50.7-0.10.3
Food seeking constrained by brief footshock0.10.10.1-0.2-0.30.4
Seeking ratio, punishment vs. effort0.40.91.40.2-1.21.2
Retroperitoneal fat weight0.31.23.1-1.80.3-0.5
Reaction time number correct0.00.00.00.20.2-0.2
Reaction time mean minus median0.00.10.20.20.2-0.4
Reaction time mean minus median AUC0.10.30.7-0.30.5-0.8
Reaction time num false alarms1.11.92.9-0.91.7-1.4
Reaction time num false alarms AUC1.22.64.2-1.02.0-1.6
Reaction time trials correct on left0.00.00.00.20.2-0.2
Reaction time trials on left0.00.00.00.10.2-0.2
Reaction time mean1.43.23.92.0-1.81.6
Reaction time mean AUC1.22.93.61.9-1.71.5
Median of all reaction times3.04.85.22.3-2.22.1
Reaction time omissions0.30.40.60.8-0.70.5
Reaction time false alarm rate1.31.72.7-1.01.6-1.3
Reaction time premature initiation rate2.13.24.31.2-2.02.1
Reaction time premature initiations0.82.63.21.2-1.71.8
Std. dev. reaction times0.10.30.80.9-0.40.2
Reaction time trials completed0.00.00.00.10.2-0.2
Reaction time trials AUC0.00.00.00.10.2-0.2
Run reversals in cocaine runway, females0.50.60.8-0.40.9-0.9
Run reversals in cocaine runway, males3.43.84.1-1.82.0-2.0
Latency to leave start box in cocaine runway0.50.71.3-1.10.6-0.6
Latency to leave start box in cocaine runway, F0.70.81.7-1.30.5-0.8
Latency to leave start box in cocaine runway, M0.10.10.2-0.30.4-0.0
Std. dev. time between licks in bursts0.40.81.40.6-1.20.9
Total sessions with >9 infusions2.83.44.8-2.21.6-1.7
Short access day 1 total inactive lever presses0.51.02.4-1.50.6-0.6
Short access day 10 total inactive lever presses0.00.00.10.0-0.00.2
Short access day 1 total infusions1.12.32.7-1.51.6-1.3
Short access day 10 total infusions2.03.33.9-2.01.9-1.6
Short access total infusions1.62.22.9-1.71.5-1.2
Short access day 1 locomotion0.20.30.4-0.60.5-0.5
Short access day 10 total locomotion1.66.68.2-2.42.4-2.9
Short access total locomotion1.52.22.3-1.51.5-1.5
One hour access (0.3 mA shock)0.60.71.2-0.91.1-0.4
Compulsive drug intake0.60.91.20.7-1.11.1
One hour access (shock baseline)0.92.53.6-1.51.9-1.3
Social response proportion0.30.40.8-0.90.5-0.4
Social responses2.43.23.7-1.91.6-1.8
Social time0.91.42.0-0.91.2-1.4
Soleus weight0.10.20.3-0.1-0.50.5
Bone: stiffness3.46.27.71.9-2.72.8
Tibialis anterior weight0.10.50.90.5-1.00.6
Time to tail flick, vehicle, before self-admin0.00.00.1-0.10.2-0.3
Time to tail flick, vehicle, after self-admin0.10.30.4-0.40.6-0.6
Time to tail flick, test, before self-admin2.22.63.2-1.81.5-1.5
Time to tail flick, test, after self-admin0.30.30.40.3-0.60.6
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.3-0.40.2
Delta time to tail flick, test, before/after SA2.63.23.92.0-1.61.7
Tibia length0.00.10.2-0.40.3-0.3
Ambulatory time before self-admin0.72.23.1-1.01.8-1.6
Ambulatory time after self-admin0.00.10.2-0.10.5-0.1
Bone: tissue strength1.61.72.50.9-1.61.3
Total heroin consumption1.72.03.00.7-1.61.7
Bone: trabecular number0.10.10.30.60.2-0.2
Bone: trabecular spacing0.71.02.4-1.60.3-0.6
Bone: trabecular thickness0.10.10.20.40.20.1
Bone: trabecular tissue density1.01.82.31.5-1.21.3
Water consumed over 24 hours0.30.61.0-1.00.6-0.6
Number of responses in last shaping day0.10.10.10.3-0.30.2