Hub : Genes

Pip4k2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Pip4k2b 0.08 0.07 7.8e-05 0.02 0.04 0.01 0.03 1.2e-02 3.2e-04 1.3e-02 4.1e-04
2 pVTA isoform ratio XM_008768131.4 0.03 0.03 7.4e-03 0.01 0.01 -0 0.01 2.6e-02 6.8e-02 5.3e-01 5.0e-02
3 Brain isoform ratio XM_008768131.4 0.02 0.02 4.9e-03 0.02 0.02 0.01 0.02 6.7e-03 3.9e-03 1.9e-02 1.2e-02
4 Brain isoform ratio NM_053550.2 0.02 0.02 5.0e-03 0.02 0.02 0.01 0.02 7.4e-03 3.8e-03 1.7e-02 1.1e-02
5 NAcc gene expression Pip4k2b 0.13 0.07 0.0e+00 0.19 0.2 0.2 0.19 1.1e-28 1.6e-29 9.4e-29 1.3e-28
6 Adipose gene expression Pip4k2b 0.14 0.12 3.5e-04 0 0.02 0.01 0.01 9.1e-02 1.7e-03 1.8e-02 1.2e-02
7 PL isoform ratio NM_053550.2 0.07 0.08 4.6e-03 0.01 0.01 0.01 0.01 9.4e-03 2.4e-02 6.0e-02 2.3e-02
8 PL isoform ratio XM_008768131.4 0.06 0.08 4.6e-03 0.02 0.01 0.01 0.02 1.3e-03 3.3e-02 1.9e-02 5.5e-03
9 Liver gene expression Pip4k2b 0.08 0.05 2.4e-13 0.1 0.1 0.1 0.1 1.2e-11 2.2e-11 1.8e-11 1.7e-11
10 Adipose mRNA stability Pip4k2b 0.04 0.03 4.0e-05 0.04 0.03 0.04 0.03 3.0e-05 1.4e-04 5.5e-05 1.3e-04
11 NAcc isoform ratio NM_053550.2 0.02 0.02 1.4e-03 0.02 0.02 0.01 0.02 7.3e-04 1.5e-03 2.9e-03 1.2e-03
12 PL gene expression Pip4k2b 0.15 0.06 0.0e+00 0.26 0.25 0.26 0.26 5.8e-28 2.8e-27 1.0e-27 1.1e-27
13 Brain gene expression Pip4k2b 0.17 0.1 6.1e-16 0.16 0.16 0.16 0.16 4.0e-15 1.7e-14 7.0e-15 9.2e-15
14 pVTA gene expression Pip4k2b 0.24 0.16 3.2e-09 0.11 0.11 0.1 0.11 2.2e-09 3.1e-09 1.7e-08 3.6e-09
15 NAcc isoform ratio XM_008768131.4 0.02 0.02 3.9e-03 0.01 0.01 0.01 0.01 4.5e-03 1.1e-02 1.2e-02 1.1e-02
16 BLA gene expression Pip4k2b 0.17 0.07 2.0e-12 0.21 0.2 0.19 0.2 1.6e-11 1.1e-10 1.7e-10 4.2e-11
17 IC gene expression Pip4k2b 0.4 0.17 1.1e-13 0.3 0.31 0.27 0.32 3.4e-13 9.4e-14 1.3e-11 8.7e-14
18 pVTA isoform ratio NM_053550.2 0.03 0.03 5.9e-03 0.01 0.01 0 0.01 2.3e-02 7.6e-02 1.4e-01 4.0e-02
19 IL gene expression Pip4k2b 0.21 0.15 4.0e-04 0.14 0.02 0.12 0.03 4.1e-04 9.6e-02 7.5e-04 7.6e-02
20 OFC gene expression Pip4k2b 0.21 0.15 2.2e-03 0.06 0.04 0.08 0.06 1.6e-02 4.4e-02 5.7e-03 1.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density1.62.73.71.81.91.8-1.81.81.7-1.61.61.71.7-1.71.71.51.61.51.51.5-1.61.51.4
Area under the delay curve1.01.12.40.41.11.0-1.01.00.0-1.01.01.31.2-1.11.11.21.11.11.11.1-1.00.9-1.5
BMI with tail1.55.314.4-0.3-2.7-2.02.1-2.10.82.5-2.5-2.4-2.42.3-2.3-2.3-2.3-2.4-2.2-2.21.9-2.23.8
BMI without tail1.33.95.1-1.8-2.3-2.22.2-2.1-1.52.1-2.1-2.0-1.92.0-2.0-2.0-2.0-2.0-2.0-2.02.0-2.2-0.6
Body weight6.930.033.5-5.5-5.6-5.85.8-5.7-4.95.6-5.6-5.6-5.65.6-5.5-5.7-5.6-5.7-5.5-5.55.4-5.4-3.2
Weight adjusted by age0.20.30.6-0.6-0.4-0.40.4-0.4-0.80.5-0.5-0.4-0.40.6-0.5-0.6-0.5-0.5-0.5-0.50.4-0.4-0.7
Bone surface0.00.10.20.0-0.0-0.10.1-0.10.20.0-0.0-0.1-0.10.1-0.1-0.4-0.3-0.3-0.4-0.40.3-0.40.3
Bone volume0.10.10.60.50.40.3-0.30.30.6-0.20.20.20.2-0.20.20.00.10.0-0.0-0.0-0.1-0.00.7
Breakpoint value in progressive ratio session2.02.33.5-1.9-1.5-1.61.6-1.6-1.81.6-1.6-1.3-1.31.4-1.3-1.7-1.3-1.7-1.4-1.41.4-1.4-1.8
Number of licking bursts0.40.71.00.90.80.8-0.80.80.8-1.01.00.70.7-0.80.80.90.80.90.90.9-0.90.80.0
Context. condit. distance diff. score0.30.40.7-0.7-0.9-0.70.7-0.7-0.70.8-0.8-0.5-0.50.7-0.7-0.6-0.6-0.6-0.6-0.60.5-0.50.0
Locomotion velocity, session 11.31.42.1-1.4-1.1-1.21.2-1.2-1.41.1-1.1-1.3-1.31.2-1.2-1.2-1.3-1.2-1.3-1.31.2-1.30.0
Locomotion distance, session 13.94.96.7-2.6-2.4-2.42.4-2.4-2.52.3-2.3-2.2-2.32.2-2.2-2.0-2.2-2.0-2.1-2.12.1-2.30.0
Locomotion velocity, session 20.81.01.4-1.2-0.9-1.01.0-1.1-1.21.0-1.0-1.1-1.11.0-1.0-0.9-1.1-0.9-1.1-1.10.9-0.90.0
Locomotion distance, session 21.11.52.1-1.4-1.3-1.31.3-1.3-1.51.3-1.3-1.3-1.31.3-1.3-1.0-1.3-1.0-1.2-1.21.1-1.20.0
Locomotion velocity, session 30.20.20.4-0.5-0.4-0.50.5-0.5-0.50.2-0.2-0.5-0.50.4-0.4-0.4-0.5-0.4-0.4-0.40.5-0.70.0
Locomotion distance, session 30.50.60.8-0.9-0.8-0.80.8-0.8-0.90.6-0.6-0.8-0.80.9-0.9-0.7-0.8-0.7-0.8-0.80.7-0.80.0
Stereotopy head waving bouts, day 33.54.15.32.32.22.2-2.22.22.3-2.22.22.02.0-2.22.22.02.02.01.91.9-1.81.90.0
Stereotopy head waving duration, day 30.60.81.00.91.00.9-0.90.91.0-1.01.00.80.8-1.01.00.90.90.90.80.8-0.70.80.0
Locomotion velocity, session 70.50.61.2-0.9-1.1-0.90.9-0.9-0.80.7-0.7-0.6-0.60.8-0.8-0.6-0.6-0.6-0.6-0.60.6-0.80.0
Locomotion distance, session 70.00.00.2-0.1-0.4-0.20.2-0.20.00.2-0.20.00.10.2-0.2-0.10.0-0.1-0.1-0.1-0.0-0.10.0
Stereotopy head waving bouts, day 70.91.01.91.21.41.2-1.21.21.0-1.31.31.00.9-1.11.10.81.00.80.90.9-0.60.60.0
Stereotopy head waving duration, day 70.10.20.60.50.80.6-0.50.50.3-0.70.70.30.3-0.40.40.10.30.10.30.30.00.00.0
Locomotion velocity, session 86.37.610.1-3.2-3.0-3.02.9-2.9-3.12.8-2.8-2.7-2.72.8-2.8-2.7-2.7-2.7-2.8-2.82.7-2.60.0
Locomotion distance, session 81.82.63.5-1.8-1.7-1.71.7-1.7-1.91.6-1.6-1.5-1.61.7-1.7-1.6-1.6-1.6-1.6-1.61.6-1.70.0
Degree of sensitization distance0.10.10.3-0.3-0.5-0.40.4-0.3-0.20.5-0.5-0.2-0.20.3-0.3-0.3-0.2-0.3-0.3-0.30.2-0.20.0
Degree of sensitization stereotypy1.41.52.41.51.61.4-1.41.41.3-1.51.51.21.2-1.31.31.01.21.01.21.2-0.80.80.0
Conditioned locomotion0.20.30.50.60.50.5-0.50.50.6-0.70.70.60.5-0.50.50.50.60.50.60.6-0.50.40.0
Cocaine response after cond. corrected1.72.03.51.71.91.6-1.61.61.5-1.51.51.31.4-1.21.21.41.51.41.41.4-1.41.30.0
Cocaine response after cond. not corrected2.73.25.02.12.22.0-2.02.02.0-2.02.01.81.8-1.71.71.71.71.71.71.7-1.61.60.0
Cocaine response before conditioning0.81.01.81.10.91.0-1.01.11.3-1.21.21.11.1-1.21.20.80.80.90.90.9-0.80.70.0
Saline control response0.10.10.20.30.10.2-0.20.20.4-0.40.40.30.3-0.30.30.20.20.20.20.2-0.40.40.0
Bone: connectivity density2.23.54.21.92.12.0-2.02.01.7-2.02.02.02.0-2.02.01.71.91.81.81.8-1.81.81.1
Bone: cortical apparent density3.44.67.61.72.82.4-2.42.41.1-2.52.52.42.4-2.42.42.02.11.92.02.0-1.92.1-0.4
Bone: cortical area0.10.20.30.30.60.5-0.50.50.2-0.60.60.60.6-0.50.50.50.40.40.40.4-0.40.4-0.3
Bone: cortical porosity1.21.32.21.11.01.1-1.11.01.1-0.90.91.01.0-1.01.01.51.11.41.41.4-1.41.30.8
Bone: cortical porosity1.21.32.31.10.91.1-1.11.01.0-0.80.81.11.0-1.01.01.51.11.41.41.4-1.41.40.7
Bone: cortical thickness1.01.62.90.61.71.3-1.41.30.1-1.51.51.41.4-1.31.31.31.21.31.21.2-1.21.3-1.1
Bone: cortical thickness4.04.75.81.32.42.2-2.22.20.7-2.42.42.42.4-2.32.32.42.42.42.32.3-2.22.3-1.1
Bone: cortical tissue density3.44.67.61.62.82.4-2.42.41.0-2.52.52.42.4-2.42.41.92.11.92.02.0-1.92.1-0.5
Condit. Reinf. active minus inactive responses0.40.40.60.70.60.7-0.70.70.8-0.60.60.70.7-0.70.70.70.70.70.70.7-0.60.60.0
Condit. Reinf. active-inactive response ratio0.90.91.31.10.71.0-1.01.01.1-0.80.81.01.0-1.01.01.01.11.11.01.0-0.90.90.0
Condit. Reinf. active responses0.50.70.90.90.90.9-0.90.90.9-0.70.70.80.8-0.80.80.80.80.90.80.8-0.80.80.0
Condit. Reinf. inactive responses0.40.50.90.80.90.8-0.80.80.8-0.60.60.70.6-0.70.70.70.60.70.60.6-0.70.80.0
Incentive salience index mean1.21.52.01.41.21.3-1.31.31.4-1.11.11.21.2-1.31.31.31.21.31.31.3-1.21.20.0
Condit. Reinf. lever presses1.21.72.41.51.31.4-1.41.41.6-1.11.11.31.3-1.31.31.41.31.41.41.4-1.41.40.0
Condit. Reinf. active minus inactive responses0.70.91.31.00.80.9-0.90.90.9-1.11.10.80.8-0.90.91.01.01.11.11.1-1.11.10.0
Condit. Reinf. active-inactive response ratio0.30.30.50.60.60.6-0.60.60.5-0.60.60.50.5-0.50.50.60.60.60.70.7-0.60.70.0
Condit. Reinf. active responses1.11.62.01.31.01.2-1.21.21.4-1.41.41.21.2-1.21.21.31.31.31.41.4-1.41.40.0
Condit. Reinf. inactive responses2.12.74.11.81.41.6-1.61.72.0-1.61.61.71.6-1.81.81.61.71.71.71.7-1.81.70.0
Condit. Reinf. lever presses0.00.10.20.10.10.1-0.10.10.1-0.50.50.10.1-0.20.20.30.20.30.40.4-0.40.30.0
Condit. Reinf. lever reinforcers received1.11.52.11.31.01.2-1.21.21.3-1.41.41.11.1-1.21.21.21.31.31.41.4-1.41.40.0
Conditioned reinforcement - actives0.81.42.01.01.01.0-1.01.11.2-1.11.11.31.4-1.11.11.41.41.41.41.4-1.31.30.7
Conditioned reinforcement - inactives0.10.10.40.1-0.00.2-0.20.20.2-0.00.00.40.5-0.30.30.70.50.60.50.5-0.50.5-0.1
Conditioned locomotion1.82.33.61.81.21.5-1.51.51.8-1.11.11.51.6-1.21.21.61.61.51.61.6-1.91.61.9
Patch foraging indifference point 0 sec1.12.12.61.31.61.5-1.51.51.2-1.61.61.41.4-1.51.51.51.31.61.51.5-1.61.60.6
Patch foraging indifference point AUC0.10.20.6-0.10.1-0.20.2-0.2-0.20.3-0.3-0.5-0.50.4-0.3-0.6-0.6-0.6-0.6-0.60.7-0.70.1
Delay disc. indifference point, 0s delay1.61.72.30.81.41.4-1.41.40.4-1.31.31.51.4-1.41.51.51.41.41.41.4-1.41.5-0.3
Delay disc. indifference point, 16s delay0.50.50.90.40.90.7-0.80.80.2-0.80.80.90.8-0.80.70.50.70.50.80.8-0.60.5-0.9
Delay disc. indifference point, 2s delay2.32.53.50.91.71.6-1.61.60.5-1.61.61.81.7-1.71.81.91.51.81.51.5-1.81.7-1.1
Delay disc. indifference point, 24s delay0.20.22.1-0.30.40.0-0.00.1-0.5-0.20.20.1-0.0-0.20.1-0.3-0.2-0.3-0.2-0.20.6-0.7-1.4
Delay disc. indifference point, 4s delay0.80.87.8-0.50.70.5-0.60.5-1.3-0.40.40.70.8-0.60.60.80.60.70.60.6-0.60.6-2.8
Delay disc. indifference point, 8s delay0.80.91.40.60.80.8-0.90.90.5-0.70.71.21.2-1.01.01.21.11.11.11.1-1.00.9-0.6
Indifference point function ln k0.00.10.2-0.0-0.00.1-0.10.1-0.1-0.30.30.30.3-0.30.30.40.40.40.40.4-0.30.2-0.4
Indifference point function log k0.00.10.2-0.0-0.00.1-0.10.1-0.1-0.30.30.30.3-0.30.30.40.40.40.40.4-0.30.2-0.4
Patch foraging total patch changes 0 sec0.71.21.61.01.21.1-1.11.10.9-1.31.31.11.1-1.21.11.20.91.21.11.1-1.21.20.4
Patch foraging total patch changes 12 sec3.44.46.32.12.52.3-2.32.31.9-2.32.32.12.1-2.12.12.11.92.12.02.0-2.22.21.1
Patch foraging total patch changes 18 sec0.20.31.90.80.80.5-0.50.50.9-0.40.40.10.1-0.30.30.2-0.00.20.10.1-0.40.21.4
Patch foraging total patch changes 24 sec0.81.42.91.31.71.4-1.41.31.1-1.21.21.01.0-1.11.01.10.91.11.11.1-1.01.01.0
Patch foraging total patch changes 6 sec0.61.01.71.21.31.2-1.11.11.0-1.01.00.80.8-1.01.00.90.70.90.80.8-0.91.00.9
Patch foraging time to switch 0 sec0.10.10.50.40.10.2-0.20.20.5-0.00.00.30.2-0.10.10.30.40.30.40.4-0.50.50.7
Patch foraging water rate 0 sec0.00.00.2-0.10.10.0-0.00.0-0.1-0.30.30.00.0-0.10.1-0.1-0.2-0.1-0.2-0.20.3-0.4-0.2
Patch foraging water rate 12 sec0.30.72.8-1.2-0.7-0.80.8-0.8-1.40.7-0.7-0.7-0.80.7-0.7-0.5-0.7-0.5-0.7-0.70.8-0.7-1.7
Patch foraging water rate 18 sec0.60.92.80.00.70.7-0.70.7-0.4-0.80.81.01.1-1.01.01.11.11.11.21.2-0.80.8-1.7
Patch foraging water rate 24 sec0.30.40.80.50.50.6-0.60.60.5-0.70.70.70.6-0.90.90.70.70.70.70.7-0.60.70.1
Patch foraging water rate 6 sec0.71.01.40.91.21.1-1.11.10.8-1.11.11.11.1-1.21.21.01.01.00.90.9-0.80.90.1
Seeking ratio, delayed vs. immediate footshock0.30.30.7-0.0-0.7-0.40.4-0.40.10.6-0.6-0.5-0.60.4-0.3-0.7-0.8-0.7-0.7-0.70.6-0.60.8
Distance traveled before self-admin0.10.10.7-0.4-0.9-0.40.4-0.4-0.40.4-0.4-0.1-0.10.3-0.3-0.0-0.1-0.1-0.1-0.10.0-0.2-0.3
Distance traveled after self-admin0.50.61.3-0.7-1.1-0.90.9-0.9-0.20.8-0.8-0.6-0.60.6-0.6-0.9-0.7-0.8-0.8-0.80.8-1.00.4
Extensor digitorum longus weight7.730.433.2-5.3-5.7-5.75.7-5.7-4.75.7-5.7-5.8-5.85.7-5.7-5.7-5.6-5.7-5.6-5.65.6-5.7-2.4
Bone: elastic displacement0.00.00.20.30.10.2-0.20.10.2-0.20.20.00.0-0.00.00.30.10.30.20.2-0.30.40.4
Bone: elastic work0.00.00.5-0.30.1-0.10.1-0.1-0.4-0.10.1-0.1-0.10.1-0.10.0-0.10.0-0.0-0.00.0-0.0-0.7
Bone: endosteal estimation1.43.04.3-1.5-2.1-1.91.9-1.9-1.01.8-1.8-1.8-1.81.8-1.8-1.8-1.8-1.7-1.8-1.81.6-1.8-0.1
Bone: endosteal perimeter1.42.94.4-1.2-2.1-1.81.8-1.8-0.51.9-1.9-1.8-1.81.7-1.7-1.8-1.8-1.7-1.8-1.81.5-1.70.7
Epididymis fat weight0.00.10.2-0.4-0.2-0.40.4-0.4-0.20.3-0.3-0.3-0.30.3-0.3-0.5-0.2-0.4-0.3-0.30.4-0.4-0.4
Delta time in closed arm before/after self-admin3.73.44.8-1.7-2.2-2.02.0-2.0-1.61.8-1.8-1.9-1.91.8-1.8-2.0-1.9-2.0-1.9-1.91.9-1.8-0.8
Delta time in open arm before/after self-admin0.10.10.5-0.20.20.1-0.10.0-0.30.1-0.10.00.0-0.10.10.30.10.30.10.1-0.30.1-0.7
Diff in mean of infusions in LGA sessions0.00.00.3-0.2-0.6-0.30.3-0.30.20.2-0.2-0.1-0.10.00.0-0.2-0.1-0.2-0.1-0.10.00.1-0.2
Delay discount exponential model param0.70.83.3-0.1-0.9-0.70.7-0.80.30.7-0.7-1.0-1.00.9-0.9-1.0-0.9-0.8-0.8-0.80.8-0.71.8
Extinction: sum of active levers before priming0.60.71.7-1.0-0.9-0.80.8-0.7-1.00.5-0.5-0.6-0.60.5-0.5-1.0-0.7-0.8-0.7-0.71.3-1.1-1.3
Active lever presses in extinction session 60.10.10.30.2-0.00.1-0.10.10.1-0.10.10.10.1-0.10.0-0.4-0.1-0.4-0.1-0.10.5-0.30.4
Bone: final force1.11.72.21.01.51.3-1.31.40.9-1.51.51.41.4-1.41.41.31.41.31.31.3-1.31.30.1
Bone: final moment0.91.51.80.91.31.2-1.21.20.8-1.31.31.31.3-1.31.31.31.31.31.21.2-1.31.3-0.1
Food consumed during 24 hour testing period0.91.32.0-1.3-1.0-1.21.2-1.2-1.40.9-0.9-1.3-1.31.1-1.1-1.2-1.2-1.1-1.1-1.11.2-1.20.0
Glucose0.30.51.10.31.00.8-0.80.8-0.1-0.90.90.70.7-0.80.80.80.70.80.80.8-0.50.6-0.8
Heart weight2.84.36.1-1.6-2.5-2.12.2-2.2-1.32.3-2.3-2.2-2.22.1-2.1-2.2-2.2-2.2-2.1-2.12.1-2.10.1
Delay discount hyperbolic model param0.60.73.5-0.0-0.8-0.70.7-0.70.40.7-0.7-1.0-0.90.8-0.9-1.0-0.8-0.8-0.8-0.80.8-0.71.9
Intermittent access intake day 1-15 change0.10.10.80.0-0.5-0.30.3-0.30.50.3-0.3-0.1-0.10.2-0.2-0.2-0.2-0.3-0.2-0.20.4-0.30.9
Intermittent access intake escalation0.10.10.80.1-0.4-0.30.3-0.20.60.3-0.3-0.1-0.10.2-0.2-0.2-0.2-0.2-0.2-0.20.3-0.20.9
Intermittent access intake escalation 20.60.71.2-0.2-0.8-0.70.7-0.70.30.8-0.8-0.8-0.80.7-0.7-1.0-0.9-1.0-0.9-0.91.1-1.01.1
Intermitt. access day 1 inactive lever presses0.20.61.30.50.60.7-0.70.70.5-0.60.60.90.9-0.80.81.10.91.10.90.9-0.91.0-0.2
Intermitt. access day 15 inactive lever presses0.40.81.81.30.71.0-1.01.01.1-0.70.70.80.8-0.70.70.80.70.80.70.7-0.80.81.3
Intermitt. access escalation Index1.01.41.9-1.2-0.9-1.21.2-1.2-1.20.9-0.9-1.4-1.41.2-1.2-1.3-1.3-1.4-1.3-1.30.8-1.0-0.9
Intermittent access day 1 total infusions0.00.00.1-0.10.00.0-0.00.0-0.10.0-0.00.20.2-0.10.10.20.40.30.40.4-0.10.0-0.2
Intermittent access day 15 total infusions0.00.10.2-0.2-0.4-0.30.3-0.30.20.2-0.2-0.0-0.00.2-0.2-0.1-0.0-0.1-0.0-0.00.3-0.30.3
Intermittent access terminal intake (last 3 days)0.10.10.80.40.10.1-0.10.20.8-0.10.10.30.2-0.20.20.20.30.20.30.3-0.0-0.00.9
Intermittent access total infusions0.00.00.1-0.3-0.2-0.30.3-0.3-0.10.3-0.3-0.1-0.10.1-0.1-0.1-0.0-0.10.00.00.3-0.3-0.1
Intermittent access day 1 locomotion0.20.20.50.20.30.4-0.40.40.1-0.30.30.50.6-0.50.50.60.70.70.70.7-0.70.5-0.2
Intermittent access day 15 total locomotion0.50.91.41.00.60.9-0.90.90.9-0.90.91.11.2-1.01.01.11.11.11.11.1-0.70.70.7
Intermittent access total locomotion1.31.62.21.20.91.2-1.21.21.1-1.11.11.41.4-1.21.21.51.41.51.41.4-1.31.40.8
Intermittent access standard deviation0.10.21.40.60.20.3-0.30.31.0-0.20.20.40.4-0.50.50.20.30.20.30.3-0.10.21.2
Left kidney weight1.46.59.7-3.0-2.3-2.62.6-2.5-3.12.2-2.2-2.4-2.52.4-2.4-2.6-2.4-2.6-2.4-2.42.6-2.5-3.0
Right kidney weight0.21.02.3-1.3-0.6-0.90.9-0.9-1.40.6-0.6-1.0-1.00.9-0.9-1.1-1.0-1.1-0.9-0.91.0-0.8-1.5
Cocaine induced anxiety3.04.25.6-1.8-2.4-2.22.2-2.1-1.42.1-2.1-2.1-2.12.1-2.1-2.1-2.2-2.2-2.2-2.22.2-2.2-0.5
Post-drug Anxiety0.60.71.3-0.5-1.1-0.90.9-0.9-0.10.9-0.9-0.8-0.80.8-0.8-0.8-0.9-0.9-0.9-0.90.8-0.70.4
Baseline Anxiety3.23.74.51.82.12.0-2.02.01.5-2.02.01.91.9-2.02.02.02.02.02.02.0-2.02.10.7
Tail length3.513.570.7-5.3-2.4-3.33.2-3.2-6.42.5-2.5-2.5-2.52.7-2.6-2.8-2.6-2.7-2.6-2.63.3-3.0-8.4
Length with tail6.025.957.7-6.5-4.3-5.15.1-5.0-6.84.4-4.4-4.6-4.54.5-4.5-4.8-4.6-4.8-4.7-4.74.9-4.6-7.6
Length without tail3.310.512.3-3.3-3.2-3.43.4-3.4-3.13.1-3.1-3.5-3.53.3-3.3-3.4-3.4-3.4-3.3-3.33.2-3.0-2.2
Times rat made contact with spout0.60.71.31.01.01.0-1.00.90.7-1.11.10.70.7-0.80.80.90.70.90.80.8-0.80.70.0
Lifetime Intake0.00.00.0-0.2-0.1-0.20.2-0.10.00.1-0.10.00.10.0-0.00.00.10.00.10.10.1-0.2-0.0
Liver weight, left0.20.40.8-0.6-0.3-0.50.5-0.5-0.60.6-0.6-0.5-0.50.6-0.6-0.8-0.5-0.8-0.6-0.60.9-0.8-0.5
Liver weight, right0.20.41.8-0.10.90.5-0.50.5-0.4-0.70.70.60.6-0.50.50.40.70.50.70.70.10.1-1.4
Locomotor activity0.60.91.71.20.91.0-1.01.01.3-0.90.90.81.0-0.90.90.60.90.60.80.8-0.80.71.3
Locomotor testing distance2.95.37.92.72.02.4-2.42.42.8-2.12.12.32.4-2.52.52.02.32.02.12.1-2.22.12.4
Locomotor testing rearing3.26.48.22.62.52.7-2.72.72.3-2.62.62.72.7-2.92.82.32.72.32.52.5-2.22.21.3
Locomotion in novel chamber1.92.43.51.11.81.9-1.91.80.0-1.81.81.61.5-1.81.81.61.51.61.51.5-1.31.2-0.8
Locomotion in novel chamber post-restriction0.30.52.40.90.60.6-0.50.51.2-0.70.70.20.2-0.40.40.30.60.40.50.5-0.80.61.6
Fecal boli incidents, locomotor time 10.30.42.00.2-0.7-0.30.3-0.40.40.7-0.7-0.5-0.60.6-0.6-0.7-0.6-0.7-0.5-0.50.6-0.51.4
Change in fecal boli incidents, locomotor task0.40.40.80.10.70.6-0.60.6-0.1-0.80.80.80.7-0.90.80.70.70.70.70.7-0.50.5-0.8
Time >=10cm from walls, locomotor time 10.80.91.60.81.10.9-0.90.90.7-0.70.70.80.9-0.80.71.31.01.31.01.0-0.90.91.1
Bouts of movement, locomotor time 10.30.30.8-0.7-0.6-0.70.7-0.6-0.50.9-0.9-0.5-0.50.6-0.6-0.5-0.5-0.5-0.4-0.40.2-0.2-0.7
Total resting periods, locomotor time 10.40.50.9-0.8-0.7-0.80.8-0.8-0.61.0-1.0-0.6-0.60.7-0.7-0.6-0.6-0.6-0.5-0.50.3-0.2-0.9
Rest time, locomotor task time 10.10.10.3-0.2-0.1-0.20.2-0.2-0.20.3-0.3-0.3-0.30.1-0.10.1-0.10.10.10.1-0.40.5-0.5
Distance moved, locomotor task time 10.10.10.3-0.00.30.3-0.30.3-0.1-0.50.50.50.6-0.40.40.10.40.20.30.3-0.0-0.0-0.4
Vertical activity count, locomotor time 10.00.10.4-0.2-0.6-0.20.2-0.2-0.10.2-0.2-0.00.10.1-0.1-0.20.1-0.2-0.1-0.10.5-0.70.1
Time >=10cm from walls, locomotor time 21.11.62.60.91.31.3-1.31.30.5-1.11.11.31.4-1.21.21.61.51.61.51.5-1.31.40.2
Bouts of movement, locomotor time 20.10.20.60.50.20.4-0.40.40.6-0.00.00.60.6-0.20.30.30.60.30.60.6-0.60.80.8
Total resting periods, locomotor time 20.10.10.70.4-0.10.2-0.20.20.50.3-0.30.40.40.00.10.20.40.20.40.4-0.50.70.8
Rest time, locomotor task time 20.81.02.3-0.9-1.4-1.11.1-1.1-0.71.5-1.5-1.0-1.11.0-1.0-0.9-1.0-1.0-0.8-0.80.7-0.6-0.4
Distance moved, locomotor task time 20.10.22.0-0.60.1-0.10.1-0.1-0.8-0.20.2-0.10.00.0-0.1-0.2-0.1-0.2-0.2-0.20.3-0.4-1.4
Vertical activity count, locomotor time 20.10.21.7-0.6-0.2-0.30.2-0.2-0.70.0-0.0-0.10.1-0.0-0.10.00.10.0-0.0-0.00.3-0.4-1.3
Light reinforcement 11.33.14.11.91.61.7-1.71.72.0-1.71.71.61.7-1.71.81.71.71.71.81.8-2.02.01.6
Light reinforcement 20.50.71.00.81.00.9-0.90.90.7-1.01.00.80.9-0.91.00.80.90.80.90.9-0.91.00.3
Bone: marrow area1.32.84.1-1.5-2.0-1.91.9-1.9-1.01.8-1.8-1.8-1.81.8-1.8-1.8-1.7-1.7-1.7-1.71.6-1.7-0.1
Bone: maximum diameter0.00.10.80.40.10.1-0.10.10.7-0.10.10.10.1-0.10.1-0.0-0.00.0-0.0-0.0-0.20.00.9
Bone: maximum force0.00.00.1-0.00.20.1-0.10.10.1-0.30.30.20.2-0.20.20.20.20.20.10.1-0.10.0-0.3
Bone: maximum moment0.00.00.2-0.10.10.0-0.00.0-0.0-0.20.20.20.2-0.10.10.20.10.20.10.1-0.20.0-0.4
Mean time between licks in bursts1.02.43.7-1.7-1.7-1.61.6-1.6-1.81.9-1.9-1.5-1.61.5-1.5-1.4-1.5-1.4-1.4-1.41.3-1.30.0
Mean num. licks in bursts0.00.00.00.0-0.00.0-0.00.0-0.00.2-0.2-0.00.0-0.00.0-0.0-0.10.0-0.1-0.10.1-0.00.0
Cd content in liver0.70.81.5-0.6-1.2-1.01.0-1.0-0.11.1-1.1-0.7-0.70.8-0.8-0.9-0.8-0.9-0.9-0.90.8-0.90.3
Co content in liver2.22.53.0-1.6-1.6-1.61.6-1.6-1.41.6-1.6-1.5-1.51.6-1.6-1.7-1.6-1.7-1.7-1.71.6-1.5-0.9
Cu content in liver0.81.01.4-0.9-0.9-1.01.0-1.0-0.81.1-1.1-1.1-1.11.1-1.1-1.0-1.2-1.0-1.1-1.10.7-0.7-0.4
Fe content in liver2.22.73.1-1.8-1.6-1.71.7-1.7-1.81.6-1.6-1.7-1.71.7-1.7-1.6-1.7-1.7-1.7-1.71.5-1.4-1.3
K content in liver0.00.00.3-0.20.20.0-0.0-0.0-0.50.3-0.3-0.1-0.10.1-0.10.2-0.00.10.00.0-0.0-0.1-0.5
Mg content in liver0.20.22.2-0.50.30.1-0.10.1-0.90.0-0.00.00.0-0.00.00.20.10.20.10.10.0-0.0-1.5
Mn content in liver0.10.10.5-0.10.20.1-0.20.1-0.30.1-0.10.10.1-0.20.20.30.20.20.20.2-0.30.3-0.7
Na content in liver0.20.31.80.80.50.5-0.50.40.9-0.20.20.20.2-0.20.20.30.20.30.30.3-0.50.41.3
Rb content in liver1.31.62.01.21.11.3-1.31.31.1-1.11.11.31.3-1.31.31.41.31.41.31.3-1.41.40.6
Se content in liver2.73.24.61.92.12.0-2.01.91.7-1.71.71.81.8-1.81.81.71.81.81.81.8-1.81.71.2
Sr content in liver1.51.33.7-1.5-1.0-1.11.1-1.1-1.71.0-1.0-1.0-1.01.0-1.0-1.0-1.0-1.0-1.0-1.01.1-1.0-1.9
Zn content in liver1.41.62.21.21.31.3-1.31.31.0-1.11.11.31.3-1.31.31.41.21.31.31.3-1.51.50.5
Bone: minimum diameter0.40.81.1-1.0-1.0-1.01.0-0.9-0.80.8-0.8-0.8-0.80.8-0.8-1.0-1.1-0.9-1.0-1.01.0-1.0-0.8
Time in familiar zone, hab. session 10.50.50.70.80.50.7-0.70.70.8-0.80.80.70.8-0.80.80.70.80.70.80.8-0.50.40.0
Time in novel zone, hab. session 10.70.71.41.00.90.9-0.90.91.0-0.80.80.80.7-0.80.80.80.70.80.70.7-1.01.20.0
Total zone transitions, hab. session 12.33.14.4-2.1-1.8-1.91.9-1.9-2.11.8-1.8-1.8-1.81.9-1.9-1.6-1.8-1.6-1.7-1.71.8-1.70.0
Total locomotion distance, hab. session 10.00.00.0-0.1-0.2-0.20.2-0.2-0.10.1-0.1-0.1-0.10.1-0.10.1-0.10.1-0.1-0.1-0.10.10.0
Locomotion velocity, hab. session 10.40.60.9-1.0-1.0-0.90.9-0.9-0.90.8-0.8-0.8-0.80.8-0.8-0.6-0.8-0.6-0.7-0.70.6-0.60.0
Time in familiar zone, hab. session 20.80.81.11.00.60.8-0.80.91.1-0.90.91.01.0-0.90.91.01.00.91.01.0-0.90.90.0
Time in novel zone, hab. session 20.00.00.00.10.20.1-0.10.10.1-0.00.00.00.0-0.10.10.10.00.10.00.0-0.10.20.0
Total zone transitions, hab. session 20.50.71.0-1.0-1.0-0.90.9-0.9-0.91.0-1.0-0.8-0.80.8-0.8-0.6-0.8-0.6-0.7-0.70.7-0.80.0
Total locomotion distance, hab. session 20.00.00.2-0.3-0.4-0.30.3-0.3-0.20.3-0.3-0.2-0.20.1-0.1-0.0-0.2-0.1-0.1-0.10.1-0.10.0
Locomotion velocity, hab. session 20.10.20.4-0.6-0.7-0.60.6-0.6-0.40.5-0.5-0.4-0.40.4-0.4-0.3-0.4-0.3-0.4-0.40.4-0.40.0
Novel to familiar place preference ratio1.61.82.6-1.5-1.1-1.31.3-1.3-1.61.1-1.1-1.4-1.41.2-1.2-1.5-1.4-1.5-1.3-1.31.5-1.40.0
Novelty place preference0.91.01.5-1.2-0.8-1.01.0-1.0-1.20.8-0.8-1.0-1.00.9-0.9-1.1-1.0-1.1-1.0-1.01.2-1.10.0
Time in novel zone, NPP test0.20.30.5-0.6-0.4-0.50.5-0.5-0.70.4-0.4-0.5-0.50.4-0.4-0.6-0.6-0.6-0.5-0.50.7-0.60.0
Total zone transitions, NPP test0.30.40.6-0.8-0.7-0.70.7-0.7-0.70.6-0.6-0.7-0.70.7-0.7-0.4-0.7-0.4-0.5-0.50.5-0.60.0
Total locomotion distance, NPP test0.00.00.10.00.00.0-0.0-0.00.1-0.10.1-0.0-0.00.0-0.00.3-0.00.30.10.1-0.30.20.0
Locomotion velocity, NPP test0.20.30.5-0.7-0.6-0.70.7-0.7-0.70.5-0.5-0.6-0.70.6-0.6-0.4-0.7-0.4-0.5-0.50.4-0.50.0
Intraocular pressure1.42.02.9-1.5-1.5-1.51.4-1.4-1.41.3-1.3-1.2-1.11.2-1.3-1.7-1.2-1.6-1.5-1.51.7-1.6-1.4
Delta distance traveled before/after self-admin0.50.50.9-0.4-0.8-0.70.7-0.7-0.00.8-0.8-0.7-0.70.5-0.6-1.0-0.8-0.8-0.8-0.80.9-0.90.6
Delta ambulatory time before/after self-admin0.10.20.5-0.2-0.2-0.40.4-0.40.10.3-0.3-0.4-0.40.2-0.2-0.7-0.5-0.6-0.5-0.50.5-0.60.4
Parametrial fat weight0.51.21.60.81.01.0-1.01.00.8-1.21.21.21.2-1.11.21.11.21.11.21.2-1.11.3-0.1
Pavlov. Cond. lever latency2.63.24.4-2.1-1.8-1.91.9-1.9-2.11.8-1.8-1.9-1.81.9-1.9-1.8-1.8-1.8-1.8-1.81.7-1.60.0
Pavlov. Cond. magazine entry latency9.111.716.14.03.63.7-3.73.73.9-3.63.63.53.4-3.53.53.23.43.33.33.3-3.23.20.0
Pavlov. Cond. change in total contacts7.88.311.53.43.33.2-3.23.23.2-3.23.22.92.8-3.13.12.62.82.72.72.7-2.42.40.0
Pavlov. Cond. index score8.811.115.13.93.53.6-3.63.63.8-3.53.53.43.4-3.43.43.23.33.23.23.2-3.13.00.0
Pavlov. Cond. latency score6.78.511.73.43.13.2-3.23.13.3-3.13.13.02.9-3.03.02.82.92.82.82.8-2.72.60.0
Pavlov. Cond. lever contacts3.33.95.42.32.02.1-2.12.12.3-2.02.02.02.0-2.02.02.02.02.01.91.9-2.01.90.0
Pavlov. Cond. magazine entry number13.116.522.5-4.7-4.3-4.44.4-4.4-4.64.3-4.3-4.1-4.14.1-4.1-3.9-4.0-3.9-3.9-3.93.7-3.60.0
Pavlov. Cond. intertrial magazine entries1.51.82.5-1.5-1.3-1.41.4-1.4-1.61.5-1.5-1.4-1.41.3-1.3-1.2-1.4-1.2-1.3-1.31.2-1.10.0
Pavlov. Cond. lever-magazine prob. diff.10.312.717.44.23.73.9-3.83.84.1-3.83.83.63.6-3.73.73.43.53.43.43.4-3.33.20.0
Pavlov. Cond. response bias10.112.517.04.13.73.8-3.83.84.1-3.73.73.63.6-3.63.63.43.53.43.43.4-3.33.30.0
Pavlov. Cond. lever latency0.20.30.8-0.6-0.5-0.60.6-0.5-0.40.9-0.9-0.4-0.50.5-0.5-0.5-0.5-0.6-0.5-0.50.5-0.50.0
Pavlov. Cond. magazine entry latency0.00.10.2-0.2-0.2-0.20.2-0.2-0.4-0.00.0-0.3-0.30.3-0.3-0.1-0.3-0.2-0.2-0.20.1-0.20.0
Pavlov. Cond. change in total contacts0.40.60.80.80.60.8-0.80.70.7-0.90.90.60.7-0.70.70.90.80.90.80.8-0.90.80.0
Pavlov. Cond. index score0.10.20.50.40.40.4-0.40.40.2-0.70.70.20.3-0.30.30.40.30.40.40.4-0.40.30.0
Pavlov. Cond. latency score0.10.10.40.30.30.4-0.30.30.1-0.70.70.20.2-0.30.30.40.30.30.30.3-0.30.20.0
Pavlov. Cond. lever contacts0.40.61.20.80.80.8-0.80.80.7-1.11.10.60.7-0.70.70.80.70.80.80.8-0.80.70.0
Pavlov. Cond. magazine entry number0.20.20.4-0.5-0.4-0.50.5-0.4-0.30.6-0.6-0.3-0.40.4-0.4-0.6-0.4-0.5-0.4-0.40.6-0.50.0
Pavlov. Cond. intertrial magazine entries1.42.12.8-1.7-1.5-1.61.6-1.5-1.51.5-1.5-1.5-1.51.4-1.4-1.6-1.5-1.5-1.4-1.41.4-1.30.0
Pavlov. Cond. lever-magazine prob. diff.0.00.10.30.20.20.2-0.20.20.0-0.50.50.10.1-0.20.20.30.20.30.20.2-0.30.20.0
Pavlov. Cond. response bias0.70.91.41.11.01.0-1.01.00.9-1.21.20.80.9-0.90.91.00.91.01.01.0-1.01.00.0
Time in closed arm before self-admin1.92.43.71.71.71.5-1.51.61.9-1.51.51.41.4-1.51.51.51.41.51.41.4-1.91.71.4
Time in closed arm after self-admin0.30.30.5-0.3-0.7-0.60.6-0.6-0.10.4-0.4-0.7-0.70.5-0.5-0.7-0.7-0.7-0.6-0.60.5-0.50.3
Time in open arm before self-admin2.72.94.1-1.5-2.0-1.71.7-1.7-1.41.8-1.8-1.7-1.71.9-1.9-1.9-1.8-1.9-1.8-1.81.7-1.5-0.2
Time in open arm after self-admin0.50.61.0-0.8-0.7-0.70.7-0.7-1.00.9-0.9-0.7-0.70.8-0.8-0.5-0.7-0.6-0.8-0.80.6-0.6-0.8
Bone: periosteal estimation0.10.20.3-0.4-0.6-0.50.5-0.5-0.10.4-0.4-0.4-0.40.4-0.4-0.5-0.5-0.5-0.5-0.50.4-0.50.1
Bone: periosteal perimeter0.50.81.3-0.6-1.1-1.01.0-1.0-0.21.0-1.0-0.9-0.90.9-0.9-1.0-1.1-1.0-1.0-1.00.8-0.90.4
Bone: post-yield work0.50.71.3-0.8-1.1-0.90.9-0.9-0.51.0-1.0-0.8-0.80.8-0.8-0.8-0.7-0.7-0.8-0.80.7-0.8-0.2
Progressive ratio test 1 active lever presses0.40.50.80.20.90.6-0.60.70.2-0.70.70.90.8-0.80.80.80.90.70.90.9-0.70.7-0.4
Progressive ratio test 1 breakpoint0.40.50.80.20.90.6-0.60.60.3-0.70.70.90.8-0.80.80.80.90.70.90.9-0.70.7-0.2
Progressive ratio test 1 inactive lever presses0.10.20.40.10.10.2-0.20.20.2-0.10.10.40.5-0.30.30.60.60.60.60.6-0.50.5-0.2
Progressive ratio test 2 active lever presses0.40.40.70.50.70.7-0.70.70.4-0.60.60.80.8-0.60.60.80.80.80.80.8-0.40.50.1
Progressive ratio test 2 breakpoint0.40.50.80.50.80.7-0.70.70.4-0.70.70.80.9-0.70.70.90.90.80.90.9-0.50.50.0
Progressive ratio test 2 inactive lever presses0.10.20.5-0.5-0.6-0.40.4-0.4-0.60.6-0.6-0.3-0.30.5-0.5-0.3-0.3-0.3-0.3-0.30.7-0.6-0.3
Incentive Sensitization - Responses0.30.50.80.70.70.8-0.80.80.5-0.70.70.70.8-0.70.70.90.80.80.80.8-0.50.60.2
Incentive Sensitization - Breakpoint0.30.30.50.60.60.7-0.70.60.4-0.50.50.60.6-0.50.50.70.60.70.70.7-0.30.40.1
Sum of active levers in priming session hrs 5-60.20.21.1-0.20.30.2-0.30.3-0.5-0.40.40.40.4-0.40.50.20.50.20.40.40.4-0.3-1.0
Progressive ratio0.00.00.2-0.2-0.2-0.20.2-0.2-0.20.0-0.0-0.1-0.10.0-0.00.0-0.30.0-0.4-0.4-0.20.0-0.2
Food seeking constrained by brief footshock0.50.61.20.81.10.7-0.70.81.0-0.70.70.80.8-0.60.60.90.81.00.70.7-0.70.50.8
Seeking ratio, punishment vs. effort0.20.30.60.50.80.5-0.50.60.5-0.40.40.50.6-0.30.40.30.70.40.70.70.00.10.3
Retroperitoneal fat weight0.20.71.30.60.70.7-0.70.80.7-0.80.81.01.0-0.90.91.01.00.91.01.0-1.11.10.0
Reaction time number correct0.50.91.3-1.0-1.1-1.11.1-1.1-1.01.1-1.1-1.1-1.11.0-1.0-0.8-1.1-0.8-0.9-0.90.7-0.6-0.6
Reaction time mean minus median0.00.00.1-0.1-0.2-0.20.2-0.20.0-0.10.1-0.1-0.10.2-0.3-0.2-0.2-0.2-0.2-0.2-0.00.10.2
Reaction time mean minus median AUC0.20.61.00.80.60.7-0.70.70.8-0.90.90.70.7-0.70.60.60.60.70.70.7-0.91.00.8
Reaction time num false alarms0.50.71.00.70.90.9-0.90.90.6-0.80.80.91.0-1.00.90.90.90.91.01.0-0.80.80.1
Reaction time num false alarms AUC0.30.50.70.50.80.7-0.70.70.4-0.70.70.80.9-0.80.70.80.70.80.90.9-0.60.6-0.1
Reaction time trials correct on left0.50.91.3-1.0-1.1-1.11.1-1.1-1.01.1-1.1-1.1-1.11.0-1.0-0.8-1.1-0.8-0.9-0.90.7-0.6-0.6
Reaction time trials on left0.50.91.2-1.0-1.1-1.01.0-1.0-0.91.0-1.0-1.0-1.10.9-1.0-0.8-1.0-0.8-0.8-0.80.6-0.6-0.6
Reaction time mean0.10.11.50.50.20.2-0.20.20.6-0.10.1-0.00.00.1-0.1-0.1-0.0-0.1-0.1-0.1-0.20.11.2
Reaction time mean AUC0.10.11.40.50.10.1-0.10.10.5-0.00.0-0.0-0.00.2-0.2-0.2-0.1-0.2-0.1-0.1-0.10.11.2
Median of all reaction times0.20.42.81.00.60.6-0.60.51.0-0.30.30.30.3-0.20.20.20.30.20.30.3-0.40.31.7
Reaction time omissions0.30.50.90.40.90.6-0.60.60.4-0.90.90.60.8-0.70.70.70.80.70.70.7-0.70.8-0.2
Reaction time false alarm rate1.01.41.91.11.31.2-1.21.20.9-1.21.21.31.4-1.31.21.21.21.21.31.3-1.01.00.3
Reaction time premature initiation rate0.30.41.10.10.70.5-0.50.5-0.0-0.70.70.50.6-0.70.80.70.60.70.60.6-0.90.9-1.0
Reaction time premature initiations0.10.22.0-0.7-0.2-0.40.3-0.3-0.70.2-0.2-0.3-0.30.1-0.1-0.1-0.3-0.1-0.2-0.2-0.20.2-1.4
Std. dev. reaction times0.00.10.20.20.20.2-0.20.20.3-0.40.40.10.1-0.10.10.00.00.00.10.1-0.30.40.3
Reaction time trials completed0.50.91.2-1.0-1.1-1.01.0-1.0-0.91.0-1.0-1.0-1.10.9-1.0-0.8-1.0-0.8-0.8-0.80.6-0.6-0.6
Reaction time trials AUC0.40.71.0-0.9-1.0-0.90.9-0.9-0.80.9-0.9-1.0-1.00.9-0.9-0.7-0.9-0.7-0.7-0.70.5-0.5-0.5
Run reversals in cocaine runway, females1.21.21.9-1.3-1.4-1.21.2-1.2-1.21.1-1.1-1.0-0.91.1-1.1-0.9-1.0-0.9-1.0-1.01.3-1.1-1.2
Run reversals in cocaine runway, males0.60.63.01.3-0.00.7-0.70.61.3-0.40.40.50.5-0.50.50.80.60.70.60.6-0.60.61.7
Latency to leave start box in cocaine runway2.42.73.8-1.0-1.9-1.61.7-1.7-0.61.9-1.9-1.8-1.72.0-1.9-1.8-1.6-1.8-1.6-1.61.4-1.60.8
Latency to leave start box in cocaine runway, F2.83.24.6-1.2-2.0-1.81.8-1.9-0.82.0-2.0-2.1-1.92.2-2.1-1.9-2.0-1.9-2.0-2.01.3-1.50.4
Latency to leave start box in cocaine runway, M0.40.40.9-0.2-0.7-0.50.5-0.5-0.20.7-0.7-0.6-0.50.7-0.7-0.8-0.4-0.7-0.4-0.40.8-0.90.8
Std. dev. time between licks in bursts0.30.40.7-0.7-0.6-0.60.6-0.7-0.80.6-0.6-0.7-0.70.7-0.7-0.8-0.7-0.7-0.7-0.70.7-0.70.0
Total sessions with >9 infusions0.00.00.1-0.00.10.0-0.10.10.1-0.20.20.30.3-0.30.30.30.30.30.30.3-0.20.0-0.1
Short access day 1 total inactive lever presses0.91.21.70.51.00.9-0.91.00.2-1.01.01.21.3-1.21.21.21.21.21.21.2-1.11.2-1.2
Short access day 10 total inactive lever presses0.20.51.0-0.0-0.9-0.70.7-0.70.41.0-1.0-0.8-0.60.8-0.8-0.6-0.6-0.6-0.6-0.60.2-0.31.0
Short access day 1 total infusions0.00.00.10.10.10.1-0.10.20.1-0.00.00.20.2-0.20.20.1-0.00.1-0.0-0.0-0.1-0.0-0.0
Short access day 10 total infusions0.20.20.30.50.50.5-0.50.50.5-0.40.40.60.5-0.60.60.40.50.40.50.5-0.1-0.10.6
Short access total infusions0.00.00.0-0.1-0.0-0.10.1-0.0-0.00.1-0.10.0-0.0-0.00.0-0.1-0.1-0.1-0.1-0.10.1-0.20.0
Short access day 1 locomotion0.60.70.80.90.90.9-0.90.90.9-0.80.80.90.9-0.90.90.90.80.80.80.8-0.90.70.7
Short access day 10 total locomotion2.03.74.32.11.72.0-2.02.02.0-1.81.82.02.0-2.12.12.01.82.01.81.8-1.91.91.9
Short access total locomotion0.40.40.80.70.50.6-0.60.60.8-0.50.50.60.7-0.70.70.70.60.70.60.6-0.80.70.9
One hour access (0.3 mA shock)0.00.00.1-0.10.1-0.00.00.00.2-0.00.00.30.3-0.00.00.00.20.10.30.3-0.20.1-0.3
Compulsive drug intake0.30.43.5-0.40.80.2-0.20.3-0.6-0.60.60.40.4-0.20.20.40.40.40.40.4-0.60.6-1.9
One hour access (shock baseline)0.10.21.40.2-0.5-0.20.2-0.20.60.4-0.4-0.1-0.10.1-0.1-0.2-0.1-0.2-0.1-0.10.3-0.41.2
Social response proportion0.20.22.5-0.60.0-0.10.0-0.1-0.90.0-0.00.20.2-0.10.00.60.20.50.30.3-0.40.5-1.6
Social responses0.10.10.40.10.30.2-0.30.20.0-0.20.20.40.4-0.30.30.60.40.60.50.5-0.50.4-0.4
Social time0.10.11.10.4-0.00.0-0.00.00.60.0-0.0-0.0-0.00.0-0.1-0.10.1-0.10.00.00.0-0.11.0
Soleus weight0.41.21.91.01.41.2-1.21.20.9-1.31.31.11.1-1.21.20.91.11.01.11.1-1.00.90.4
Bone: stiffness0.00.00.1-0.00.20.1-0.10.20.1-0.30.30.30.3-0.30.30.10.20.10.10.1-0.30.2-0.3
Tibialis anterior weight1.55.06.3-2.4-2.1-2.22.2-2.2-2.52.1-2.1-2.3-2.32.2-2.2-2.3-2.2-2.3-2.2-2.22.3-2.3-2.0
Time to tail flick, vehicle, before self-admin0.30.30.70.20.60.5-0.50.60.1-0.60.60.80.8-0.70.80.40.60.40.50.5-0.20.3-0.8
Time to tail flick, vehicle, after self-admin0.10.11.30.50.30.3-0.30.20.5-0.50.50.20.2-0.20.10.0-0.1-0.0-0.1-0.1-0.00.01.1
Time to tail flick, test, before self-admin0.20.20.5-0.3-0.5-0.60.6-0.50.10.4-0.4-0.6-0.60.4-0.4-0.5-0.6-0.5-0.5-0.50.7-0.60.3
Time to tail flick, test, after self-admin0.10.10.20.40.40.3-0.30.30.4-0.20.20.20.2-0.20.3-0.10.3-0.00.20.20.10.10.4
Delta time to tail flick, vehicle, before/after SA0.60.62.91.00.70.7-0.70.71.1-0.70.70.40.4-0.60.50.70.40.70.50.5-0.60.61.7
Delta time to tail flick, test, before/after SA1.41.42.00.81.31.3-1.31.30.3-1.11.11.31.3-1.31.31.21.41.21.31.3-1.21.3-0.5
Tibia length0.82.22.6-1.6-1.3-1.51.5-1.5-1.61.3-1.3-1.5-1.51.4-1.4-1.6-1.6-1.6-1.6-1.61.5-1.4-1.3
Ambulatory time before self-admin0.30.51.5-0.7-1.2-0.80.8-0.8-0.61.0-1.0-0.6-0.60.8-0.8-0.4-0.4-0.5-0.5-0.50.4-0.5-0.2
Ambulatory time after self-admin1.82.13.0-1.3-1.7-1.61.6-1.5-0.81.5-1.5-1.3-1.31.3-1.4-1.7-1.4-1.6-1.5-1.51.6-1.7-0.1
Bone: tissue strength0.50.50.7-0.5-0.5-0.60.6-0.6-0.40.5-0.5-0.8-0.80.7-0.7-0.8-0.8-0.8-0.8-0.80.8-0.80.1
Total heroin consumption0.20.20.40.50.60.6-0.60.60.2-0.30.30.60.6-0.60.60.10.60.10.50.5-0.20.3-0.0
Bone: trabecular number4.77.89.12.83.03.0-3.03.02.6-2.92.92.92.9-2.92.92.72.82.72.72.7-2.82.71.7
Bone: trabecular spacing0.70.91.4-0.8-1.2-1.11.1-1.0-0.51.1-1.1-1.0-1.01.0-1.0-0.9-1.1-0.9-0.9-0.90.9-0.80.0
Bone: trabecular thickness0.00.00.00.10.20.1-0.10.10.00.0-0.0-0.0-0.00.0-0.0-0.10.0-0.1-0.1-0.10.1-0.10.1
Bone: trabecular tissue density0.00.00.3-0.3-0.0-0.10.1-0.1-0.40.1-0.1-0.1-0.10.1-0.1-0.1-0.2-0.1-0.1-0.10.2-0.3-0.5
Water consumed over 24 hours0.00.00.0-0.1-0.0-0.10.1-0.1-0.1-0.20.2-0.1-0.20.1-0.10.1-0.10.10.00.00.0-0.10.0
Number of responses in last shaping day0.20.20.5-0.1-0.2-0.30.3-0.3-0.10.4-0.4-0.5-0.40.4-0.4-0.5-0.5-0.5-0.5-0.50.6-0.70.6