Hub : Genes

Pikfyve

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression Pikfyve 0.61 0.18 5.0e-06 0.22 0.34 0.3 0.3 2.4e-04 3.0e-06 1.9e-05 1.9e-05
2 pVTA gene expression Pikfyve 0.1 0.06 2.5e-04 0.1 0.09 0.08 0.08 6.0e-05 1.2e-04 2.2e-04 2.8e-04
3 Brain gene expression Pikfyve 0.07 0.05 2.8e-06 0.05 0.05 0.04 0.04 8.2e-06 3.5e-05 3.3e-04 5.4e-05
4 pVTA alternative TSS XM_039084597.1 0.07 0.06 1.0e-02 0.06 0.04 0.04 0.04 2.1e-03 9.9e-03 9.8e-03 1.2e-02
5 Adipose gene expression Pikfyve 0.11 0.06 1.9e-06 0.02 0.04 0.04 0.04 1.5e-03 1.3e-05 3.4e-05 9.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bone: apparent density0.30.51.61.3-0.5-0.40.3-0.7
Area under the delay curve0.20.30.8-0.90.30.4-0.40.3
BMI with tail8.126.230.9-5.65.25.5-4.94.4
BMI without tail4.18.413.1-3.63.03.1-2.71.9
Body weight0.31.42.0-1.41.21.4-0.71.2
Weight adjusted by age0.10.10.50.7-0.3-0.2-0.30.1
Bone surface0.40.71.51.2-1.1-0.50.4-0.7
Bone volume1.22.14.52.1-1.4-1.11.1-1.2
Breakpoint value in progressive ratio session1.01.12.51.6-1.4-0.80.3-0.7
Number of licking bursts0.10.20.30.10.40.2-0.60.5
Context. condit. distance diff. score0.60.72.00.21.40.7-0.90.5
Locomotion velocity, session 11.01.11.7-0.2-1.3-1.31.2-0.7
Locomotion distance, session 10.30.41.3-1.1-0.6-0.3-0.40.1
Locomotion velocity, session 20.30.31.2-1.1-0.40.0-0.4-0.2
Locomotion distance, session 20.70.93.3-1.8-0.10.3-0.80.8
Locomotion velocity, session 30.30.40.7-0.10.80.8-0.7-0.0
Locomotion distance, session 31.41.52.01.4-1.2-1.41.2-0.8
Stereotopy head waving bouts, day 32.12.53.2-1.81.61.7-1.61.0
Stereotopy head waving duration, day 32.42.94.0-1.91.72.0-2.00.6
Locomotion velocity, session 70.00.10.1-0.20.00.2-0.30.3
Locomotion distance, session 70.20.30.8-0.4-0.9-0.50.10.6
Stereotopy head waving bouts, day 70.20.30.8-0.10.90.5-0.5-0.0
Stereotopy head waving duration, day 71.31.53.1-0.51.81.5-1.40.5
Locomotion velocity, session 80.10.10.3-0.10.40.2-0.50.1
Locomotion distance, session 80.20.40.6-0.50.70.2-0.80.6
Degree of sensitization distance1.21.23.2-1.80.50.9-1.01.0
Degree of sensitization stereotypy0.40.51.2-0.21.10.7-0.60.3
Conditioned locomotion0.91.02.00.3-1.4-1.10.6-1.3
Cocaine response after cond. corrected1.11.32.80.0-1.2-1.10.9-1.7
Cocaine response after cond. not corrected1.71.93.70.6-1.3-1.41.3-1.9
Cocaine response before conditioning0.30.41.61.30.3-0.30.40.1
Saline control response1.01.32.8-1.70.81.2-1.20.4
Bone: connectivity density0.40.61.3-0.30.51.0-1.10.5
Bone: cortical apparent density3.64.75.8-2.31.72.1-2.32.4
Bone: cortical area0.71.11.71.2-1.3-1.11.0-0.1
Bone: cortical porosity9.510.413.83.7-2.8-3.33.3-3.0
Bone: cortical porosity10.811.714.73.8-3.1-3.53.5-3.2
Bone: cortical thickness0.20.30.60.5-0.8-0.40.40.6
Bone: cortical thickness2.02.33.61.5-1.9-1.41.3-1.4
Bone: cortical tissue density4.05.26.1-2.41.92.2-2.42.5
Condit. Reinf. active minus inactive responses1.11.31.91.4-1.0-1.11.1-0.9
Condit. Reinf. active-inactive response ratio0.20.20.40.7-0.1-0.40.4-0.2
Condit. Reinf. active responses1.82.22.91.7-1.6-1.31.4-1.2
Condit. Reinf. inactive responses0.91.12.40.8-1.5-1.01.0-0.7
Incentive salience index mean1.51.82.91.7-1.4-1.21.2-1.1
Condit. Reinf. lever presses1.11.42.41.5-1.5-0.91.0-0.9
Condit. Reinf. active minus inactive responses7.89.610.92.6-3.2-3.13.1-3.3
Condit. Reinf. active-inactive response ratio7.27.58.12.5-2.8-2.72.8-2.8
Condit. Reinf. active responses5.06.98.22.2-2.8-2.62.6-2.9
Condit. Reinf. inactive responses0.20.30.50.4-0.5-0.60.5-0.7
Condit. Reinf. lever presses1.01.32.10.9-1.2-1.11.0-1.4
Condit. Reinf. lever reinforcers received5.57.79.62.4-2.8-2.82.7-3.1
Conditioned reinforcement - actives0.50.50.9-1.00.90.5-0.50.7
Conditioned reinforcement - inactives1.51.73.60.7-1.2-1.51.9-0.8
Conditioned locomotion6.17.38.9-2.62.82.8-2.23.0
Patch foraging indifference point 0 sec1.01.62.6-1.61.31.1-0.91.3
Patch foraging indifference point AUC0.30.41.60.3-1.3-0.40.2-0.1
Delay disc. indifference point, 0s delay1.61.71.9-1.41.21.4-1.41.2
Delay disc. indifference point, 16s delay0.10.10.20.1-0.2-0.10.1-0.5
Delay disc. indifference point, 2s delay1.61.72.1-1.31.51.3-1.31.2
Delay disc. indifference point, 24s delay0.20.20.4-0.60.50.4-0.40.4
Delay disc. indifference point, 4s delay1.92.03.9-2.01.21.3-1.31.1
Delay disc. indifference point, 8s delay0.10.10.3-0.5-0.0-0.10.10.1
Indifference point function ln k1.62.35.6-1.32.41.4-1.20.7
Indifference point function log k1.62.35.6-1.32.41.4-1.20.7
Patch foraging total patch changes 0 sec0.81.42.1-1.51.41.0-0.81.1
Patch foraging total patch changes 12 sec0.20.20.60.5-0.70.0-0.10.6
Patch foraging total patch changes 18 sec0.81.01.7-1.30.50.8-1.01.1
Patch foraging total patch changes 24 sec0.10.10.2-0.4-0.20.1-0.30.4
Patch foraging total patch changes 6 sec1.01.52.4-1.60.91.3-1.21.0
Patch foraging time to switch 0 sec0.10.10.30.3-0.1-0.20.5-0.3
Patch foraging water rate 0 sec0.30.51.0-0.60.40.3-0.91.0
Patch foraging water rate 12 sec0.40.61.2-0.91.10.6-0.8-0.1
Patch foraging water rate 18 sec0.60.71.11.0-0.4-0.90.8-1.1
Patch foraging water rate 24 sec0.10.10.2-0.40.5-0.20.10.1
Patch foraging water rate 6 sec1.62.33.7-1.71.51.4-1.91.0
Seeking ratio, delayed vs. immediate footshock0.80.91.60.8-0.9-0.71.0-1.3
Distance traveled before self-admin3.43.64.92.0-2.2-1.91.2-2.0
Distance traveled after self-admin0.30.41.00.60.00.3-0.71.0
Extensor digitorum longus weight2.28.813.1-3.62.33.0-3.02.7
Bone: elastic displacement0.10.20.30.10.60.5-0.4-0.1
Bone: elastic work0.70.92.61.6-0.7-0.80.6-0.6
Bone: endosteal estimation1.63.54.62.1-1.9-1.81.8-1.6
Bone: endosteal perimeter0.71.52.41.6-0.8-1.21.2-1.2
Epididymis fat weight0.10.10.30.50.1-0.30.10.5
Delta time in closed arm before/after self-admin1.11.01.6-1.31.21.0-0.90.3
Delta time in open arm before/after self-admin3.53.43.92.0-1.9-1.81.9-1.6
Diff in mean of infusions in LGA sessions0.40.51.80.00.50.6-1.3-0.1
Delay discount exponential model param0.20.20.70.9-0.3-0.30.3-0.2
Extinction: sum of active levers before priming0.20.20.60.80.20.4-0.60.3
Active lever presses in extinction session 60.20.20.40.5-0.7-0.50.1-0.2
Bone: final force1.72.85.52.3-1.8-1.61.5-0.9
Bone: final moment1.22.04.12.0-1.4-1.31.2-0.8
Food consumed during 24 hour testing period0.60.81.10.6-1.0-0.71.0-1.0
Glucose0.71.01.4-0.91.01.2-1.01.0
Heart weight0.40.61.01.00.2-0.70.8-0.7
Delay discount hyperbolic model param0.40.41.21.1-0.5-0.50.5-0.5
Intermittent access intake day 1-15 change0.10.10.6-0.10.10.20.1-0.8
Intermittent access intake escalation0.20.21.10.0-0.00.10.1-1.0
Intermittent access intake escalation 20.50.52.00.3-0.6-0.10.3-1.4
Intermitt. access day 1 inactive lever presses0.20.20.50.10.3-0.40.40.7
Intermitt. access day 15 inactive lever presses0.91.01.71.1-0.3-1.00.9-1.3
Intermitt. access escalation Index1.21.02.6-0.20.61.6-1.20.8
Intermittent access day 1 total infusions0.10.20.4-0.50.60.2-0.10.3
Intermittent access day 15 total infusions0.30.41.0-0.51.00.6-0.40.0
Intermittent access terminal intake (last 3 days)0.50.61.5-0.71.20.8-0.50.0
Intermittent access total infusions0.10.10.3-0.50.50.2-0.20.2
Intermittent access day 1 locomotion0.30.31.3-0.20.40.20.11.1
Intermittent access day 15 total locomotion0.10.10.40.10.60.2-0.00.4
Intermittent access total locomotion0.70.81.7-0.81.00.9-0.41.3
Intermittent access standard deviation0.90.91.50.8-0.5-0.91.2-1.2
Left kidney weight0.00.10.10.10.00.4-0.10.4
Right kidney weight0.00.00.00.10.10.10.20.1
Cocaine induced anxiety0.30.30.6-0.70.60.8-0.30.1
Post-drug Anxiety0.70.71.3-1.01.10.8-0.80.3
Baseline Anxiety0.30.30.80.1-0.1-0.90.2-0.7
Tail length4.212.815.33.2-3.7-3.93.9-3.1
Length with tail5.319.223.04.3-4.4-4.64.8-3.7
Length without tail1.53.45.02.2-2.0-1.82.0-0.9
Times rat made contact with spout0.91.01.51.0-1.0-1.01.2-0.8
Lifetime Intake0.50.51.1-1.00.90.5-0.50.5
Liver weight, left1.82.94.41.3-1.8-1.51.7-2.1
Liver weight, right0.61.02.00.7-1.4-0.81.0-0.9
Locomotor activity0.00.00.1-0.10.2-0.2-0.00.2
Locomotor testing distance0.10.10.4-0.30.60.00.20.1
Locomotor testing rearing0.00.00.10.20.2-0.20.4-0.1
Locomotion in novel chamber1.11.42.7-0.41.21.6-1.40.8
Locomotion in novel chamber post-restriction0.10.10.60.0-0.00.3-0.20.8
Fecal boli incidents, locomotor time 11.71.82.41.6-1.3-1.31.3-1.2
Change in fecal boli incidents, locomotor task0.20.20.7-0.3-0.2-0.40.4-0.8
Time >=10cm from walls, locomotor time 11.91.92.60.6-1.6-1.61.6-1.2
Bouts of movement, locomotor time 11.31.52.00.2-1.4-1.41.4-1.1
Total resting periods, locomotor time 10.91.01.4-0.2-1.2-1.21.2-0.7
Rest time, locomotor task time 11.51.72.30.5-1.4-1.41.4-1.5
Distance moved, locomotor task time 11.21.43.5-0.60.91.0-1.01.9
Vertical activity count, locomotor time 11.11.21.5-0.31.21.2-1.21.2
Time >=10cm from walls, locomotor time 20.60.60.90.2-0.9-1.01.0-0.6
Bouts of movement, locomotor time 20.60.71.2-0.80.70.7-0.71.1
Total resting periods, locomotor time 20.20.20.7-0.30.30.2-0.20.8
Rest time, locomotor task time 21.51.72.30.2-1.4-1.51.5-1.5
Distance moved, locomotor task time 21.31.53.3-0.91.01.1-1.11.8
Vertical activity count, locomotor time 23.84.14.9-1.62.12.2-2.21.9
Light reinforcement 11.32.43.3-1.51.51.8-1.81.0
Light reinforcement 20.91.32.11.2-1.1-1.00.7-1.5
Bone: marrow area1.53.34.12.0-1.8-1.81.8-1.5
Bone: maximum diameter1.12.02.41.5-1.4-1.51.6-0.9
Bone: maximum force0.91.63.81.9-1.3-1.11.0-0.3
Bone: maximum moment0.50.92.51.6-0.9-0.80.7-0.2
Mean time between licks in bursts0.40.50.8-0.90.70.8-0.60.4
Mean num. licks in bursts0.40.41.00.2-0.7-0.51.0-0.5
Cd content in liver0.20.20.70.20.80.4-0.30.1
Co content in liver0.20.20.7-0.20.90.2-0.50.3
Cu content in liver0.20.20.80.9-0.2-0.10.30.5
Fe content in liver0.40.51.61.3-0.3-0.50.5-0.4
K content in liver0.40.40.6-0.8-0.20.7-0.70.2
Mg content in liver0.50.50.9-0.90.30.9-0.8-0.1
Mn content in liver1.61.93.4-1.81.41.6-1.20.1
Na content in liver0.90.92.00.8-1.4-0.20.5-1.3
Rb content in liver0.00.00.1-0.20.00.1-0.2-0.0
Se content in liver0.20.30.6-0.50.80.6-0.50.3
Sr content in liver0.10.10.3-0.6-0.5-0.20.2-0.3
Zn content in liver0.30.30.9-0.20.30.5-0.60.9
Bone: minimum diameter1.63.05.02.2-1.6-1.81.8-1.0
Time in familiar zone, hab. session 11.91.82.5-1.31.51.4-1.60.8
Time in novel zone, hab. session 16.86.67.52.4-2.6-2.52.7-2.6
Total zone transitions, hab. session 10.40.61.0-0.0-1.0-0.90.6-0.9
Total locomotion distance, hab. session 11.72.43.31.0-1.8-1.71.4-1.6
Locomotion velocity, hab. session 11.31.82.71.0-1.7-1.51.2-1.3
Time in familiar zone, hab. session 20.40.51.2-0.00.30.7-0.81.1
Time in novel zone, hab. session 20.40.41.3-0.20.1-0.50.6-1.1
Total zone transitions, hab. session 20.10.10.4-0.7-0.1-0.4-0.1-0.2
Total locomotion distance, hab. session 20.10.10.3-0.2-0.2-0.50.10.0
Locomotion velocity, hab. session 20.10.10.2-0.2-0.2-0.50.10.1
Novel to familiar place preference ratio1.21.31.60.5-1.2-1.21.2-1.3
Novelty place preference1.61.62.30.6-1.5-1.21.3-1.5
Time in novel zone, NPP test1.92.03.00.8-1.5-1.31.4-1.7
Total zone transitions, NPP test0.10.20.4-0.3-0.6-0.6-0.0-0.1
Total locomotion distance, NPP test0.30.41.0-0.1-1.0-0.90.4-0.3
Locomotion velocity, NPP test0.20.20.5-0.5-0.7-0.60.10.1
Intraocular pressure3.14.45.6-2.32.41.8-1.72.2
Delta distance traveled before/after self-admin2.52.73.8-0.91.91.8-1.61.9
Delta ambulatory time before/after self-admin2.22.43.7-0.91.71.6-1.41.9
Parametrial fat weight0.20.30.60.3-0.7-0.80.50.3
Pavlov. Cond. lever latency0.00.00.10.00.30.1-0.10.2
Pavlov. Cond. magazine entry latency0.70.82.11.5-0.8-0.80.9-0.3
Pavlov. Cond. change in total contacts0.10.10.2-0.20.20.4-0.20.5
Pavlov. Cond. index score0.40.50.70.8-0.8-0.60.7-0.6
Pavlov. Cond. latency score0.30.40.60.7-0.8-0.50.6-0.6
Pavlov. Cond. lever contacts0.10.10.30.1-0.5-0.10.2-0.4
Pavlov. Cond. magazine entry number0.30.40.6-0.70.50.7-0.80.2
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.5-0.1-0.0-0.1-0.6
Pavlov. Cond. lever-magazine prob. diff.0.40.50.80.9-0.9-0.60.7-0.6
Pavlov. Cond. response bias0.40.50.70.8-0.9-0.70.9-0.4
Pavlov. Cond. lever latency1.52.02.6-1.41.31.4-1.31.6
Pavlov. Cond. magazine entry latency0.30.40.70.8-0.6-0.50.7-0.4
Pavlov. Cond. change in total contacts1.41.92.71.1-1.3-1.41.4-1.6
Pavlov. Cond. index score1.92.52.71.5-1.6-1.61.6-1.7
Pavlov. Cond. latency score1.82.22.31.5-1.5-1.51.5-1.5
Pavlov. Cond. lever contacts2.63.54.21.8-1.7-1.91.8-2.1
Pavlov. Cond. magazine entry number0.91.01.7-1.31.10.8-1.00.8
Pavlov. Cond. intertrial magazine entries1.92.43.4-1.91.61.7-1.51.0
Pavlov. Cond. lever-magazine prob. diff.1.72.22.51.4-1.5-1.51.5-1.6
Pavlov. Cond. response bias2.43.33.71.8-1.8-1.81.8-1.9
Time in closed arm before self-admin1.92.24.72.2-1.3-1.41.4-0.9
Time in closed arm after self-admin0.10.10.40.7-0.1-0.40.3-0.1
Time in open arm before self-admin3.03.26.1-2.51.61.7-1.61.2
Time in open arm after self-admin0.70.81.30.7-1.1-0.91.0-0.7
Bone: periosteal estimation1.83.75.12.3-2.0-2.02.0-1.2
Bone: periosteal perimeter1.62.63.51.9-1.5-1.71.7-1.3
Bone: post-yield work0.20.20.80.50.3-0.10.00.9
Progressive ratio test 1 active lever presses0.20.20.3-0.10.40.5-0.20.6
Progressive ratio test 1 breakpoint0.10.10.20.20.40.4-0.10.4
Progressive ratio test 1 inactive lever presses1.71.92.9-1.31.71.2-1.01.5
Progressive ratio test 2 active lever presses0.10.10.2-0.40.30.3-0.10.1
Progressive ratio test 2 breakpoint0.00.00.1-0.30.10.10.2-0.1
Progressive ratio test 2 inactive lever presses0.20.20.4-0.40.50.4-0.20.7
Incentive Sensitization - Responses0.10.10.3-0.0-0.2-0.20.6-0.4
Incentive Sensitization - Breakpoint0.10.10.3-0.1-0.2-0.10.6-0.4
Sum of active levers in priming session hrs 5-60.50.51.61.3-0.8-0.60.1-0.2
Progressive ratio0.10.10.5-0.7-0.00.00.0-0.4
Food seeking constrained by brief footshock1.82.34.5-0.61.31.7-2.11.3
Seeking ratio, punishment vs. effort0.91.11.70.30.91.1-1.21.3
Retroperitoneal fat weight0.82.64.6-1.21.61.4-1.52.1
Reaction time number correct0.40.50.9-0.71.00.6-0.9-0.4
Reaction time mean minus median0.00.00.1-0.4-0.00.30.10.0
Reaction time mean minus median AUC0.10.10.4-0.2-0.5-0.10.2-0.6
Reaction time num false alarms3.54.75.1-2.02.22.3-2.22.2
Reaction time num false alarms AUC3.14.25.3-2.32.02.1-1.91.9
Reaction time trials correct on left0.40.50.9-0.71.00.6-0.9-0.4
Reaction time trials on left0.40.61.0-0.71.00.6-0.9-0.4
Reaction time mean3.14.45.71.9-2.2-2.12.4-1.7
Reaction time mean AUC2.43.24.51.6-1.9-1.82.1-1.4
Median of all reaction times4.76.48.12.4-2.7-2.62.8-2.1
Reaction time omissions0.10.10.4-0.30.60.1-0.10.0
Reaction time false alarm rate1.62.23.6-1.51.31.4-1.21.9
Reaction time premature initiation rate0.30.41.00.4-0.5-0.60.5-1.0
Reaction time premature initiations0.20.21.1-0.20.1-0.1-0.1-1.0
Std. dev. reaction times0.50.71.40.7-0.9-0.71.2-0.7
Reaction time trials completed0.40.61.0-0.71.00.6-0.9-0.4
Reaction time trials AUC0.30.40.7-0.60.80.5-0.7-0.5
Run reversals in cocaine runway, females1.11.12.2-1.50.80.7-0.71.3
Run reversals in cocaine runway, males0.30.30.50.7-0.6-0.70.5-0.2
Latency to leave start box in cocaine runway2.83.03.9-2.01.51.6-1.71.9
Latency to leave start box in cocaine runway, F2.22.43.0-1.61.41.3-1.71.7
Latency to leave start box in cocaine runway, M0.00.00.0-0.2-0.10.2-0.1-0.1
Std. dev. time between licks in bursts3.13.85.9-2.41.71.9-2.11.3
Total sessions with >9 infusions0.20.20.6-0.70.6-0.00.40.1
Short access day 1 total inactive lever presses0.20.20.5-0.30.70.4-0.20.7
Short access day 10 total inactive lever presses1.21.42.01.4-1.1-1.31.3-0.5
Short access day 1 total infusions0.40.40.9-0.70.90.6-0.50.2
Short access day 10 total infusions0.20.20.6-0.30.0-0.30.5-0.8
Short access total infusions0.91.02.3-1.51.20.7-0.70.7
Short access day 1 locomotion0.70.71.10.9-0.8-0.91.0-0.6
Short access day 10 total locomotion0.40.51.30.6-0.5-0.71.1-0.1
Short access total locomotion0.10.10.4-0.40.10.30.20.6
One hour access (0.3 mA shock)0.10.10.30.2-0.5-0.3-0.00.1
Compulsive drug intake0.20.20.70.1-0.9-0.4-0.10.5
One hour access (shock baseline)0.00.00.20.10.3-0.00.1-0.4
Social response proportion0.20.20.50.2-0.5-0.50.1-0.7
Social responses0.50.71.40.7-1.2-0.70.5-0.9
Social time0.40.61.40.7-0.7-0.60.5-1.2
Soleus weight0.20.41.4-1.2-0.40.6-0.5-0.1
Bone: stiffness0.71.12.41.5-1.2-0.90.8-0.4
Tibialis anterior weight0.51.62.4-1.50.61.5-1.40.9
Time to tail flick, vehicle, before self-admin0.20.20.5-0.30.50.5-0.10.7
Time to tail flick, vehicle, after self-admin0.50.51.20.5-0.8-1.10.6-0.6
Time to tail flick, test, before self-admin0.40.30.9-0.0-0.6-0.90.6-0.4
Time to tail flick, test, after self-admin3.43.54.8-1.91.71.7-2.21.9
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.0-0.0-0.2-0.4-0.3
Delta time to tail flick, test, before/after SA2.42.23.3-1.11.31.7-1.81.3
Tibia length1.33.74.82.0-2.0-2.22.2-1.1
Ambulatory time before self-admin1.41.42.11.4-1.5-1.10.6-1.2
Ambulatory time after self-admin1.71.93.9-0.01.01.4-1.72.0
Bone: tissue strength0.40.40.80.10.80.3-0.50.9
Total heroin consumption0.80.91.61.2-1.3-1.00.4-0.6
Bone: trabecular number0.10.20.40.50.30.6-0.70.2
Bone: trabecular spacing0.30.30.9-0.1-0.4-0.81.00.1
Bone: trabecular thickness0.50.61.81.4-0.7-0.60.5-0.5
Bone: trabecular tissue density0.50.71.20.3-0.8-1.11.10.5
Water consumed over 24 hours0.10.10.4-0.40.20.6-0.30.2
Number of responses in last shaping day0.50.61.00.8-0.1-1.00.8-0.7