Hub : Genes

Pikfyve

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Pikfyve	0.09	0.05	1.3e-08	0.09	0.11	0.09	0.1	1.5e-07	5.1e-09	1.2e-07	3.7e-08
2	Brain	gene expression	Pikfyve	0.09	0.05	6.4e-06	0.02	0.04	0.04	0.01	3.0e-03	5.0e-05	5.5e-05	5.4e-02
3	pVTA	isoform ratio	XM_039084597.2	0.04	0.03	7.8e-03	0.03	0.02	0.02	0.02	2.3e-03	4.9e-03	5.8e-03	5.6e-03
4	Adipose	gene expression	Pikfyve	0.07	0.04	3.8e-04	-0	0.02	0.01	0.01	5.5e-01	2.7e-03	2.4e-02	4.9e-02
5	pVTA	alternative TSS	XM_039084597.2	0.04	0.03	5.5e-03	0.02	0.03	0.03	0.02	5.4e-03	1.5e-03	8.4e-04	4.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.1	0.2	0.8	0.5	-0.3	-0.1	-0.9	0.3
Area under the delay curve	0.2	0.3	0.5	-0.7	-0.3	0.4	0.7	-0.1
BMI with tail	8.2	28.4	32.0	-5.7	-5.1	5.3	5.1	5.4
BMI without tail	2.6	8.0	10.3	-3.2	-2.7	2.8	2.9	2.5
Body weight	0.1	0.6	1.3	-1.1	-0.5	0.4	1.1	0.2
Weight adjusted by age	0.3	0.5	1.1	0.9	0.6	0.1	-0.4	1.1
Bone surface	0.2	0.3	0.5	0.7	0.2	-0.3	-0.7	0.5
Bone volume	0.6	1.1	2.1	1.4	0.8	-0.8	-1.4	-0.1
Breakpoint value in progressive ratio session	1.0	1.2	2.6	1.6	1.3	-0.7	-1.1	0.1
Number of licking bursts	0.1	0.2	0.3	-0.2	-0.5	0.5	0.2	0.5
Context. condit. distance diff. score	0.4	0.5	1.7	-0.5	-1.3	0.7	0.0	0.1
Locomotion velocity, session 1	1.1	1.1	2.6	0.7	1.6	-1.1	-0.4	-1.1
Locomotion distance, session 1	0.2	0.2	0.5	-0.5	0.2	0.7	0.5	-0.3
Locomotion velocity, session 2	0.1	0.1	0.4	-0.6	-0.2	0.2	0.3	-0.1
Locomotion distance, session 2	0.5	0.8	1.8	-1.0	0.1	1.0	1.3	0.1
Locomotion velocity, session 3	0.7	0.8	2.4	-0.7	-1.6	0.6	-0.1	1.0
Locomotion distance, session 3	1.5	1.6	2.1	1.4	1.4	-1.3	-1.0	-1.2
Stereotopy head waving bouts, day 3	2.4	2.8	4.3	-1.9	-2.1	1.4	1.2	1.7
Stereotopy head waving duration, day 3	3.3	3.9	7.5	-2.1	-2.7	1.8	0.8	2.0
Locomotion velocity, session 7	0.1	0.1	0.2	-0.0	0.1	0.4	0.3	0.3
Locomotion distance, session 7	0.4	0.5	1.8	0.3	1.3	-0.0	0.5	-0.6
Stereotopy head waving bouts, day 7	0.2	0.2	0.8	-0.3	-0.9	0.1	-0.1	-0.1
Stereotopy head waving duration, day 7	1.6	2.0	5.6	-1.3	-2.4	1.2	0.4	0.9
Locomotion velocity, session 8	0.2	0.2	0.4	-0.3	-0.6	0.6	0.0	0.6
Locomotion distance, session 8	0.2	0.3	0.7	-0.6	-0.6	0.8	0.5	0.1
Degree of sensitization distance	0.8	0.8	1.3	-1.1	-0.4	1.0	1.2	0.6
Degree of sensitization stereotypy	0.3	0.4	1.2	-0.6	-1.1	0.4	0.2	-0.2
Conditioned locomotion	0.3	0.4	1.0	0.7	0.6	-0.1	-1.0	-0.0
Cocaine response after cond. corrected	1.0	1.2	2.6	0.6	0.4	-1.2	-1.2	-1.6
Cocaine response after cond. not corrected	1.8	2.1	4.0	1.0	0.7	-1.6	-1.6	-2.0
Cocaine response before conditioning	0.2	0.2	0.5	0.7	0.4	-0.5	-0.4	-0.3
Saline control response	1.1	1.5	2.3	-1.2	-1.2	1.3	0.6	1.5
Bone: connectivity density	0.9	1.4	2.4	-1.0	-1.4	1.2	0.6	1.5
Bone: cortical apparent density	2.0	2.7	3.7	-1.7	-1.2	1.5	1.9	1.7
Bone: cortical area	0.6	1.0	3.1	1.2	1.8	-0.5	-0.1	0.3
Bone: cortical porosity	9.8	10.6	11.9	3.4	2.6	-3.3	-3.4	-3.4
Bone: cortical porosity	11.0	11.9	13.6	3.7	3.0	-3.5	-3.6	-3.5
Bone: cortical thickness	0.4	0.6	2.1	0.6	1.4	-0.1	0.6	0.6
Bone: cortical thickness	0.9	1.0	2.0	1.2	0.9	-1.4	-1.0	0.0
Bone: cortical tissue density	2.2	3.0	4.0	-1.8	-1.4	1.6	2.0	1.7
Condit. Reinf. active minus inactive responses	1.1	1.2	1.9	1.4	1.1	-1.3	-1.1	0.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	0.6	0.3	-0.7	-0.5	0.4
Condit. Reinf. active responses	1.4	1.8	2.9	1.7	1.5	-1.5	-1.2	0.2
Condit. Reinf. inactive responses	0.7	0.8	2.1	1.0	1.4	-0.9	-0.4	-0.1
Incentive salience index mean	1.2	1.4	2.4	1.6	1.2	-1.3	-1.2	0.3
Condit. Reinf. lever presses	0.6	0.8	1.5	1.2	1.1	-0.8	-0.7	0.5
Condit. Reinf. active minus inactive responses	6.2	8.1	9.5	3.0	2.6	-3.0	-3.1	-2.5
Condit. Reinf. active-inactive response ratio	5.6	6.4	7.8	2.8	2.3	-2.6	-2.8	-2.1
Condit. Reinf. active responses	4.0	5.5	7.3	2.5	2.1	-2.5	-2.7	-1.9
Condit. Reinf. inactive responses	0.2	0.2	0.4	0.5	0.3	-0.6	-0.6	-0.3
Condit. Reinf. lever presses	0.7	0.9	2.2	1.1	0.7	-0.8	-1.5	-0.2
Condit. Reinf. lever reinforcers received	4.4	6.1	8.4	2.6	2.1	-2.5	-2.9	-2.1
Conditioned reinforcement - actives	0.9	1.5	2.1	-1.4	-1.4	1.0	1.1	1.1
Conditioned reinforcement - inactives	1.4	2.0	3.5	1.2	1.9	-1.9	-0.6	-1.2
Conditioned locomotion	5.2	6.8	12.2	-2.9	-2.0	2.1	3.5	2.3
Patch foraging indifference point 0 sec	0.6	1.1	1.7	-1.3	-0.7	0.9	1.3	0.9
Patch foraging indifference point AUC	0.4	0.5	1.4	0.8	1.2	-0.7	-0.2	0.1
Delay disc. indifference point, 0s delay	1.5	1.7	2.3	-1.5	-1.3	1.4	1.4	0.7
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.4	0.1
Delay disc. indifference point, 2s delay	1.4	1.5	2.1	-1.4	-1.3	1.3	1.2	0.7
Delay disc. indifference point, 24s delay	0.3	0.3	0.6	-0.5	-0.4	0.5	0.5	0.8
Delay disc. indifference point, 4s delay	1.6	1.7	2.8	-1.7	-1.1	1.4	1.5	0.5
Delay disc. indifference point, 8s delay	0.1	0.2	0.5	-0.2	0.4	-0.2	0.3	-0.7
Indifference point function ln k	1.2	2.2	4.3	-1.6	-2.1	1.6	0.6	1.0
Indifference point function log k	1.2	2.2	4.3	-1.6	-2.1	1.6	0.6	1.0
Patch foraging total patch changes 0 sec	0.4	0.8	1.2	-1.1	-0.7	0.8	1.1	0.8
Patch foraging total patch changes 12 sec	0.4	0.5	1.6	0.5	0.8	0.1	0.3	1.3
Patch foraging total patch changes 18 sec	0.5	0.8	1.5	-0.9	-0.3	0.6	1.2	1.2
Patch foraging total patch changes 24 sec	0.1	0.1	0.4	0.0	0.3	-0.6	0.3	0.4
Patch foraging total patch changes 6 sec	1.2	1.9	2.6	-1.4	-1.1	1.6	1.2	1.5
Patch foraging time to switch 0 sec	0.1	0.1	0.3	0.2	0.1	-0.3	-0.3	-0.6
Patch foraging water rate 0 sec	0.1	0.3	0.7	-0.3	0.1	0.7	0.8	0.3
Patch foraging water rate 12 sec	0.2	0.5	1.7	-0.9	-1.3	0.2	0.0	0.1
Patch foraging water rate 18 sec	0.4	0.6	1.7	0.9	0.2	-0.4	-1.3	0.0
Patch foraging water rate 24 sec	0.3	0.4	2.0	-0.1	0.2	-0.4	0.1	-1.4
Patch foraging water rate 6 sec	1.9	2.7	3.2	-1.8	-1.7	1.8	1.3	1.5
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.6	0.8	0.1	-0.6	-1.3	0.1
Distance traveled before self-admin	1.5	2.0	3.4	1.8	1.2	-1.1	-1.9	-0.8
Distance traveled after self-admin	0.2	0.2	0.3	0.3	0.5	0.5	0.5	0.5
Extensor digitorum longus weight	2.2	8.5	11.2	-3.3	-2.6	2.6	3.2	2.7
Bone: elastic displacement	0.3	0.4	1.0	-0.2	-0.8	0.5	-0.2	1.0
Bone: elastic work	0.4	0.5	1.2	1.1	0.6	-0.1	-0.9	0.5
Bone: endosteal estimation	1.3	2.8	4.4	2.1	1.8	-1.6	-1.8	-1.0
Bone: endosteal perimeter	0.5	1.0	1.7	1.2	0.8	-0.9	-1.3	-0.6
Epididymis fat weight	0.1	0.4	1.2	-0.6	-0.1	0.7	1.1	0.4
Delta time in closed arm before/after self-admin	1.1	1.0	2.1	-1.3	-1.4	0.9	0.6	0.4
Delta time in open arm before/after self-admin	4.5	4.4	5.7	2.4	2.0	-2.2	-2.2	-1.6
Diff in mean of infusions in LGA sessions	1.4	1.6	3.7	-0.6	-1.5	1.4	0.0	1.9
Delay discount exponential model param	0.2	0.2	0.5	0.7	0.3	-0.5	-0.7	0.1
Extinction: sum of active levers before priming	0.3	0.4	1.2	0.0	0.1	0.5	0.6	1.1
Active lever presses in extinction session 6	0.5	0.5	0.7	0.8	0.8	-0.6	-0.5	-0.7
Bone: final force	1.7	2.7	4.3	2.1	1.9	-1.5	-1.4	-1.0
Bone: final moment	1.3	2.2	3.2	1.8	1.5	-1.4	-1.4	-1.1
Food consumed during 24 hour testing period	0.3	0.4	0.9	0.7	0.5	-0.6	-0.9	-0.1
Glucose	0.7	1.1	1.3	-1.1	-1.0	1.1	1.0	1.1
Heart weight	0.7	1.2	2.0	0.9	0.6	-1.4	-1.2	-1.1
Delay discount hyperbolic model param	0.3	0.3	0.6	0.8	0.3	-0.6	-0.8	0.1
Intermittent access intake day 1-15 change	0.2	0.5	1.7	-0.7	-1.3	0.5	-0.1	0.4
Intermittent access intake escalation	0.2	0.3	1.2	-0.5	-1.1	0.3	-0.3	0.2
Intermittent access intake escalation 2	0.6	0.6	2.0	-0.6	-1.4	0.6	-0.3	0.6
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.9	-0.1	0.8	-0.2	0.9	0.1
Intermitt. access day 15 inactive lever presses	0.2	0.3	1.0	0.5	-0.2	-0.6	-1.0	-0.2
Intermitt. access escalation Index	1.5	2.1	8.4	-0.5	-1.1	0.8	0.4	2.9
Intermittent access day 1 total infusions	0.0	0.1	0.2	0.1	-0.0	-0.5	-0.3	0.2
Intermittent access day 15 total infusions	0.5	0.8	1.3	-0.9	-1.2	0.7	0.5	1.1
Intermittent access terminal intake (last 3 days)	1.2	1.6	3.1	-1.3	-1.8	1.0	0.6	1.4
Intermittent access total infusions	0.6	0.7	1.2	-0.8	-0.8	0.7	0.6	1.1
Intermittent access day 1 locomotion	0.3	0.4	1.0	-0.2	0.2	-0.2	1.0	0.9
Intermittent access day 15 total locomotion	0.6	1.2	1.4	-1.1	-1.1	0.9	1.2	1.2
Intermittent access total locomotion	2.9	3.4	5.3	-2.0	-1.6	1.4	2.3	1.9
Intermittent access standard deviation	0.1	0.2	0.4	0.2	0.2	-0.5	-0.4	-0.7
Left kidney weight	0.5	2.5	4.0	-1.6	-2.0	1.2	1.0	1.9
Right kidney weight	0.5	2.4	4.2	-2.1	-1.9	1.3	1.4	0.8
Cocaine induced anxiety	0.3	0.4	0.9	-0.7	-0.5	-0.8	0.2	-0.9
Post-drug Anxiety	0.7	0.8	1.6	-1.3	-1.1	0.3	0.7	-0.6
Baseline Anxiety	0.6	0.7	1.9	-0.6	-0.9	1.4	0.2	0.6
Tail length	4.1	16.1	22.9	3.8	4.0	-4.2	-3.1	-4.8
Length with tail	4.4	19.1	25.6	4.1	4.1	-4.7	-3.8	-5.1
Length without tail	1.0	3.2	4.8	1.7	1.7	-1.9	-1.4	-2.2
Times rat made contact with spout	1.0	1.1	2.2	1.1	1.2	-1.5	-0.7	-0.6
Lifetime Intake	0.6	0.7	1.0	-1.0	-1.0	0.7	0.8	0.7
Liver weight, left	1.7	2.9	5.4	1.7	1.0	-2.1	-2.3	-0.9
Liver weight, right	0.3	0.6	1.2	-0.7	-0.7	0.6	0.5	1.1
Locomotor activity	0.1	0.1	0.3	0.1	0.4	-0.4	0.2	0.5
Locomotor testing distance	0.1	0.3	1.2	0.0	0.3	-1.1	0.2	-0.1
Locomotor testing rearing	0.1	0.2	0.8	0.3	0.3	-0.9	-0.2	-0.3
Locomotion in novel chamber	1.6	2.1	4.8	-0.9	-1.8	1.1	0.4	2.2
Locomotion in novel chamber post-restriction	0.2	0.3	1.1	0.0	0.2	0.0	0.6	1.1
Fecal boli incidents, locomotor time 1	1.1	1.6	2.0	1.4	1.0	-1.3	-1.4	-1.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.1	-0.3	-0.3	-0.4	0.0
Time >=10cm from walls, locomotor time 1	2.0	2.1	3.3	1.3	1.8	-1.8	-1.0	-1.3
Bouts of movement, locomotor time 1	2.2	2.5	5.0	1.1	1.6	-2.2	-0.8	-1.8
Total resting periods, locomotor time 1	1.8	2.0	3.9	0.7	1.5	-2.0	-0.4	-1.7
Rest time, locomotor task time 1	1.7	2.1	2.8	1.4	1.7	-1.6	-1.4	-1.2
Distance moved, locomotor task time 1	0.6	0.9	2.3	-0.7	-0.1	1.2	1.5	0.2
Vertical activity count, locomotor time 1	0.5	1.2	1.8	-0.9	-1.2	1.3	0.8	1.2
Time >=10cm from walls, locomotor time 2	0.9	1.3	2.2	0.8	1.4	-1.3	-0.4	-1.5
Bouts of movement, locomotor time 2	0.4	0.6	1.1	-0.7	-0.3	0.4	1.1	1.0
Total resting periods, locomotor time 2	0.1	0.2	0.5	-0.2	0.3	-0.2	0.7	0.6
Rest time, locomotor task time 2	0.9	1.2	1.9	1.1	1.4	-1.2	-1.1	-0.4
Distance moved, locomotor task time 2	1.0	1.2	3.3	-1.0	-0.1	1.2	1.8	-0.2
Vertical activity count, locomotor time 2	2.9	4.0	5.5	-2.1	-2.1	2.4	1.9	1.5
Light reinforcement 1	1.7	4.2	6.1	-1.8	-2.0	2.5	1.2	2.5
Light reinforcement 2	0.6	0.9	2.5	1.0	0.2	-0.4	-1.6	-1.0
Bone: marrow area	1.2	2.6	3.9	2.0	1.7	-1.5	-1.7	-1.0
Bone: maximum diameter	0.6	1.2	2.5	1.4	1.6	-0.7	-0.9	0.1
Bone: maximum force	1.1	1.9	3.1	1.8	1.7	-1.2	-1.0	-0.9
Bone: maximum moment	0.7	1.2	1.8	1.4	1.2	-1.0	-0.8	-0.9
Mean time between licks in bursts	0.4	0.9	1.2	-1.1	-1.0	1.0	0.8	0.6
Mean num. licks in bursts	0.4	0.6	1.2	0.6	1.1	-1.1	-0.2	-0.6
Cd content in liver	0.1	0.1	0.3	-0.3	-0.3	0.4	0.5	-0.3
Co content in liver	0.2	0.2	0.8	0.2	0.4	-0.2	-0.1	-0.9
Cu content in liver	0.1	0.2	0.6	0.0	0.4	0.2	0.8	0.2
Fe content in liver	0.5	0.6	0.8	0.9	0.5	-0.8	-0.9	-0.6
K content in liver	0.5	0.4	0.8	-0.9	-0.6	0.7	0.8	0.1
Mg content in liver	0.5	0.5	1.0	-1.0	-0.9	0.5	0.5	-0.1
Mn content in liver	1.5	1.6	3.1	-1.5	-1.7	0.8	0.7	1.3
Na content in liver	0.3	0.3	0.8	0.4	-0.3	-0.4	-0.9	0.7
Rb content in liver	0.2	0.3	0.5	-0.5	-0.3	0.5	0.7	0.5
Se content in liver	0.2	0.2	0.8	-0.5	-0.3	0.1	0.4	-0.9
Sr content in liver	0.5	0.4	0.8	0.6	0.6	-0.9	-0.8	-0.2
Zn content in liver	0.3	0.4	1.1	-0.6	-0.0	0.4	1.1	-0.4
Bone: minimum diameter	1.4	2.6	4.5	2.0	2.1	-1.4	-1.3	-0.8
Time in familiar zone, hab. session 1	2.6	2.5	4.0	-1.6	-2.0	1.9	0.7	1.3
Time in novel zone, hab. session 1	6.0	6.0	7.7	2.6	2.3	-2.8	-2.5	-1.9
Total zone transitions, hab. session 1	0.4	0.6	1.9	0.4	0.7	-0.3	-0.6	-1.4
Total locomotion distance, hab. session 1	1.2	1.7	2.2	1.4	1.3	-1.0	-1.5	-1.2
Locomotion velocity, hab. session 1	0.9	1.3	1.7	1.3	1.3	-0.8	-1.2	-1.1
Time in familiar zone, hab. session 2	0.4	0.4	0.6	-0.3	-0.2	0.8	0.8	0.7
Time in novel zone, hab. session 2	0.3	0.3	0.7	0.1	-0.2	-0.5	-0.8	-0.7
Total zone transitions, hab. session 2	0.1	0.1	0.4	-0.2	0.1	0.3	-0.0	-0.6
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.1	0.5	0.3	0.0	-0.4
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.1	0.5	0.3	0.1	-0.4
Novel to familiar place preference ratio	1.2	1.3	2.5	0.9	1.1	-1.1	-1.0	-1.6
Novelty place preference	1.3	1.4	2.2	1.0	1.0	-1.2	-1.2	-1.5
Time in novel zone, NPP test	1.6	1.7	2.5	1.1	1.0	-1.3	-1.4	-1.6
Total zone transitions, NPP test	0.1	0.1	0.5	0.0	0.5	0.0	0.0	-0.7
Total locomotion distance, NPP test	0.3	0.4	1.1	0.4	1.0	-0.2	-0.1	-0.8
Locomotion velocity, NPP test	0.2	0.3	0.8	0.0	0.9	0.1	0.4	-0.5
Intraocular pressure	2.5	3.6	6.0	-2.2	-1.4	2.0	2.4	1.0
Delta distance traveled before/after self-admin	1.7	1.7	2.7	-1.1	-0.9	1.2	1.6	1.6
Delta ambulatory time before/after self-admin	1.6	1.9	3.4	-1.3	-0.9	1.2	1.8	1.5
Parametrial fat weight	0.5	1.2	3.7	-0.0	1.2	-0.3	0.8	-1.9
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.3	-0.4	0.5	0.2	0.1
Pavlov. Cond. magazine entry latency	1.1	1.5	2.3	1.5	1.5	-1.3	-0.8	-0.6
Pavlov. Cond. change in total contacts	0.0	0.1	0.2	-0.1	0.2	-0.2	0.4	-0.1
Pavlov. Cond. index score	0.4	0.6	1.0	0.9	0.8	-1.0	-0.6	-0.2
Pavlov. Cond. latency score	0.4	0.5	0.9	0.8	0.7	-1.0	-0.6	-0.3
Pavlov. Cond. lever contacts	0.0	0.1	0.2	0.2	0.3	-0.4	-0.1	0.1
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	-0.7	-1.0	0.8	0.1	0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	-0.3	-0.6	0.3	-0.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.9	0.9	0.8	-0.9	-0.6	-0.2
Pavlov. Cond. response bias	0.6	0.8	1.6	0.9	1.3	-1.1	-0.4	-0.6
Pavlov. Cond. lever latency	1.1	1.5	2.9	-1.5	-0.9	1.2	1.7	0.5
Pavlov. Cond. magazine entry latency	0.3	0.3	0.6	0.8	0.5	-0.5	-0.6	0.4
Pavlov. Cond. change in total contacts	1.0	1.7	2.7	1.4	1.1	-1.3	-1.6	-0.9
Pavlov. Cond. index score	1.4	1.8	2.9	1.7	1.2	-1.3	-1.7	-0.4
Pavlov. Cond. latency score	1.3	1.7	2.5	1.6	1.2	-1.3	-1.6	-0.5
Pavlov. Cond. lever contacts	1.6	2.2	4.0	1.8	1.2	-1.4	-2.0	-0.6
Pavlov. Cond. magazine entry number	0.6	0.7	1.3	-1.1	-0.8	0.9	0.9	-0.4
Pavlov. Cond. intertrial magazine entries	1.3	2.0	3.6	-1.9	-1.7	1.3	1.4	-0.0
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	2.6	1.5	1.1	-1.3	-1.6	-0.4
Pavlov. Cond. response bias	1.6	2.2	3.8	1.8	1.3	-1.4	-1.9	-0.5
Time in closed arm before self-admin	2.0	2.5	4.3	2.1	1.6	-1.7	-1.5	-0.9
Time in closed arm after self-admin	0.3	0.3	0.6	0.5	0.2	-0.5	-0.5	-0.8
Time in open arm before self-admin	3.4	3.8	4.8	-2.2	-1.8	1.8	1.7	2.1
Time in open arm after self-admin	1.0	1.1	2.1	1.3	1.4	-0.9	-0.9	-0.1
Bone: periosteal estimation	1.3	2.8	5.1	2.1	2.3	-1.5	-1.3	-0.8
Bone: periosteal perimeter	0.9	1.6	2.7	1.6	1.5	-1.1	-1.2	-0.4
Bone: post-yield work	0.1	0.2	0.4	0.3	0.6	0.3	0.4	-0.3
Progressive ratio test 1 active lever presses	0.4	0.4	1.8	-0.3	-0.3	0.1	0.4	1.4
Progressive ratio test 1 breakpoint	0.3	0.4	1.8	-0.2	-0.2	0.0	0.3	1.3
Progressive ratio test 1 inactive lever presses	1.2	1.8	3.0	-1.3	-0.8	1.0	1.6	1.7
Progressive ratio test 2 active lever presses	0.3	0.4	1.4	-0.3	-0.5	-0.1	0.1	1.2
Progressive ratio test 2 breakpoint	0.2	0.3	1.0	-0.1	-0.4	-0.3	-0.1	1.0
Progressive ratio test 2 inactive lever presses	0.8	1.3	3.7	-0.9	-0.9	0.6	1.0	1.9
Incentive Sensitization - Responses	0.1	0.2	0.4	-0.1	-0.2	-0.5	-0.2	0.7
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	-0.1	-0.2	-0.5	-0.2	0.6
Sum of active levers in priming session hrs 5-6	1.0	0.9	2.1	1.5	1.4	-0.5	-0.6	-0.1
Progressive ratio	0.0	0.0	0.1	0.0	0.1	-0.0	-0.3	0.3
Food seeking constrained by brief footshock	2.8	3.4	5.2	-1.4	-1.9	2.2	1.1	2.3
Seeking ratio, punishment vs. effort	0.6	0.8	1.1	-0.6	-1.0	1.0	0.9	0.9
Retroperitoneal fat weight	0.5	2.1	5.5	-1.6	-0.5	1.4	2.3	0.4
Reaction time number correct	0.7	1.3	2.8	-0.8	-1.7	0.9	-0.3	1.5
Reaction time mean minus median	0.0	0.0	0.1	-0.2	0.1	-0.2	0.3	-0.1
Reaction time mean minus median AUC	0.0	0.1	0.2	0.1	-0.0	-0.4	-0.4	-0.2
Reaction time num false alarms	2.8	4.0	5.2	-2.3	-2.0	1.8	2.3	1.5
Reaction time num false alarms AUC	2.1	3.3	5.4	-2.3	-1.9	1.4	2.1	1.0
Reaction time trials correct on left	0.7	1.3	2.8	-0.8	-1.7	0.9	-0.3	1.5
Reaction time trials on left	0.7	1.3	3.0	-0.8	-1.7	0.9	-0.3	1.4
Reaction time mean	2.7	4.3	5.9	2.3	2.4	-2.4	-1.7	-1.4
Reaction time mean AUC	2.1	3.4	4.8	2.0	2.2	-2.1	-1.4	-1.3
Median of all reaction times	4.5	6.4	8.8	2.8	3.0	-2.8	-2.1	-1.6
Reaction time omissions	0.3	0.4	1.2	-0.3	-0.7	0.0	-0.4	-1.1
Reaction time false alarm rate	1.0	1.4	3.7	-1.5	-0.7	0.7	1.9	-0.2
Reaction time premature initiation rate	0.2	0.3	0.7	0.4	-0.1	-0.1	-0.8	0.8
Reaction time premature initiations	0.4	0.7	1.8	-0.2	-1.0	0.3	-0.9	1.3
Std. dev. reaction times	0.6	1.1	1.7	0.9	1.1	-1.3	-0.5	-1.1
Reaction time trials completed	0.7	1.3	3.0	-0.8	-1.7	0.9	-0.3	1.4
Reaction time trials AUC	0.6	1.2	2.5	-0.7	-1.6	0.8	-0.4	1.4
Run reversals in cocaine runway, females	0.5	0.5	1.2	-0.7	0.2	0.5	1.1	-0.6
Run reversals in cocaine runway, males	0.5	0.5	0.8	0.8	0.7	-0.6	-0.5	-0.9
Latency to leave start box in cocaine runway	2.9	3.3	4.7	-1.9	-1.2	1.9	2.2	1.7
Latency to leave start box in cocaine runway, F	2.2	2.5	3.4	-1.7	-1.2	1.9	1.8	1.2
Latency to leave start box in cocaine runway, M	1.3	1.3	2.5	-1.1	-0.8	0.9	1.0	1.6
Std. dev. time between licks in bursts	2.8	3.9	5.5	-2.3	-2.1	2.0	1.8	1.4
Total sessions with >9 infusions	0.0	0.0	0.1	-0.3	-0.1	-0.3	0.1	-0.0
Short access day 1 total inactive lever presses	0.6	0.8	1.7	-1.2	-0.7	0.4	1.3	0.1
Short access day 10 total inactive lever presses	0.4	0.9	2.0	0.9	1.4	-0.9	-0.1	-1.0
Short access day 1 total infusions	0.2	0.3	0.9	-0.6	-1.0	0.1	-0.1	-0.1
Short access day 10 total infusions	0.4	0.5	1.0	-0.7	-0.7	0.3	0.4	1.0
Short access total infusions	0.5	0.7	1.3	-1.2	-1.0	0.6	0.8	0.1
Short access day 1 locomotion	0.3	0.4	0.6	0.7	0.6	-0.8	-0.7	-0.1
Short access day 10 total locomotion	0.1	0.3	0.7	-0.4	-0.2	-0.5	0.8	0.4
Short access total locomotion	0.7	0.8	2.0	-1.1	-0.6	0.1	1.4	0.7
One hour access (0.3 mA shock)	0.6	0.7	1.8	-0.5	-0.4	0.9	0.8	1.3
Compulsive drug intake	0.1	0.1	0.3	-0.2	0.2	0.4	0.6	0.1
One hour access (shock baseline)	0.1	0.2	0.6	-0.5	-0.8	0.4	0.1	0.2
Social response proportion	0.1	0.1	0.3	0.4	0.4	0.1	-0.5	-0.1
Social responses	0.3	0.3	0.6	0.8	0.6	-0.4	-0.7	0.2
Social time	0.3	0.4	1.4	0.5	-0.2	-0.5	-1.2	-0.1
Soleus weight	0.2	0.5	1.0	-1.0	-0.9	0.3	0.4	0.4
Bone: stiffness	0.8	1.3	2.0	1.4	1.2	-1.0	-1.0	-0.9
Tibialis anterior weight	0.5	1.8	2.3	-1.5	-1.4	1.2	1.2	1.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.4	0.5	-0.5	-0.1	-0.1
Time to tail flick, vehicle, after self-admin	0.9	1.2	1.6	1.1	1.1	-1.1	-0.9	-1.3
Time to tail flick, test, before self-admin	1.0	1.1	4.2	0.4	0.7	-0.4	-0.5	-2.0
Time to tail flick, test, after self-admin	3.4	3.5	4.0	-2.0	-1.8	2.0	1.8	1.8
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.0	-0.3	0.2	-0.3	-0.4
Delta time to tail flick, test, before/after SA	4.2	4.3	10.1	-1.7	-2.0	1.6	1.4	3.2
Tibia length	1.4	3.7	7.8	2.2	2.8	-1.6	-1.2	-1.4
Ambulatory time before self-admin	0.7	1.1	2.0	1.4	0.8	-0.8	-1.4	-0.6
Ambulatory time after self-admin	1.0	1.2	2.7	-0.3	-0.2	1.2	1.3	1.6
Bone: tissue strength	0.2	0.2	0.3	-0.2	-0.3	0.6	0.3	-0.6
Total heroin consumption	0.6	0.7	1.4	1.2	1.1	-0.6	-0.7	-0.5
Bone: trabecular number	0.2	0.3	0.8	-0.3	-0.9	0.5	-0.0	0.6
Bone: trabecular spacing	0.8	1.1	2.7	0.7	1.6	-1.1	0.0	-1.0
Bone: trabecular thickness	0.4	0.5	1.0	1.0	0.6	-0.3	-0.9	-0.2
Bone: trabecular tissue density	1.7	2.5	6.0	1.3	2.4	-1.6	0.0	-1.5
Water consumed over 24 hours	0.2	0.3	1.3	0.1	-0.0	0.0	0.0	1.1
Number of responses in last shaping day	0.7	0.8	1.3	1.0	0.6	-0.9	-1.2	-0.7