Hub : Genes

Pik3cd

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Pik3cd 0.06 0.05 4.8e-05 0.05 0.04 0.04 0.04 2.8e-06 7.0e-05 3.3e-05 2.4e-05
2 PL alternative TSS XM_039110497.2 0.02 0.01 5.5e-03 0.01 0.01 -0 0 5.1e-02 1.5e-02 4.9e-01 1.2e-01
3 PL alternative TSS XM_063288141.1 0.06 0.04 3.6e-03 0.01 0.02 0.03 0.02 2.6e-02 1.1e-03 5.1e-04 2.5e-03
4 OFC gene expression Pik3cd 0.2 0.12 7.4e-04 0.04 0.06 0.07 0.05 3.5e-02 1.6e-02 8.4e-03 2.7e-02
5 Liver mRNA stability Pik3cd 0.03 0.02 5.1e-05 0.03 0.03 0.03 0.03 1.4e-04 2.3e-04 3.0e-04 2.7e-04
6 Adipose alternative TSS XM_063288135.1 0.02 0.02 9.5e-03 0.01 0 -0 0 2.0e-02 7.4e-02 3.9e-01 1.9e-01
7 Adipose mRNA stability Pik3cd 0.2 0.09 1.3e-11 0.08 0.09 0.08 0.07 8.2e-09 5.5e-10 4.3e-09 1.8e-08
8 BLA gene expression Pik3cd 0.07 0.04 9.8e-04 0 0.03 -0 0 1.6e-01 1.2e-02 4.9e-01 2.1e-01
9 IC isoform ratio XM_063288140.1 0.14 0.1 4.9e-03 0.01 0.03 0 0 1.7e-01 2.3e-02 2.7e-01 2.4e-01
10 IC gene expression Pik3cd 0.16 0.1 2.0e-05 0.08 0.11 0.08 0.09 4.0e-04 1.8e-05 4.1e-04 1.5e-04
11 Liver alternative TSS XM_063288141.1 0.13 0.08 1.7e-03 0.03 0.02 0.02 0.02 4.9e-04 1.1e-03 1.1e-03 2.0e-03
12 pVTA intron excision ratio chr5_165384439_165384521 0.06 0.04 5.0e-03 0.03 0.03 0.02 0.02 1.4e-03 3.9e-03 1.1e-02 7.7e-03
13 IL gene expression Pik3cd 0.6 0.24 1.4e-03 0.06 0.06 0.06 0.09 1.8e-02 1.4e-02 1.9e-02 4.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.10.3-0.20.40.6-0.4-0.2-0.20.20.4-0.40.5-0.00.10.1
Area under the delay curve1.11.78.5-0.20.2-2.41.2-0.8-0.4-0.6-0.80.6-0.7-2.91.51.5
BMI with tail0.10.40.7-0.80.70.4-0.8-0.6-0.8-0.20.5-0.50.7-0.80.30.3
BMI without tail0.00.10.40.20.20.5-0.60.00.0-0.70.3-0.30.5-0.40.30.3
Body weight0.20.71.51.1-0.5-1.11.01.01.0-0.8-0.70.7-0.5-1.2-0.3-0.3
Weight adjusted by age0.20.62.11.3-1.0-0.50.61.41.0-0.6-0.60.6-0.5-0.20.40.4
Bone surface0.10.20.90.8-0.60.20.20.91.0-0.3-0.10.1-0.0-0.20.20.2
Bone volume0.00.10.30.4-0.40.00.20.50.5-0.0-0.10.1-0.0-0.20.20.2
Breakpoint value in progressive ratio session0.30.50.9-0.41.00.7-0.9-0.9-0.80.30.8-0.80.90.20.70.6
Number of licking bursts0.51.52.6-0.81.40.2-0.8-1.6-1.51.41.2-1.31.3-0.91.31.3
Context. condit. distance diff. score2.83.48.0-2.12.81.4-1.8-2.2-2.21.22.1-2.02.3-0.30.80.8
Locomotion velocity, session 10.20.30.8-0.80.9-0.4-0.0-0.6-0.6-0.00.3-0.20.4-0.70.30.3
Locomotion distance, session 10.20.31.0-0.51.0-0.0-0.2-0.3-0.20.10.6-0.50.9-0.70.50.5
Locomotion velocity, session 20.81.01.9-1.11.40.6-0.8-1.1-1.01.01.2-1.11.20.60.60.7
Locomotion distance, session 20.20.20.7-0.30.80.4-0.20.00.10.50.7-0.50.90.4-0.1-0.1
Locomotion velocity, session 31.31.52.4-1.41.61.5-1.3-1.2-1.21.11.4-1.31.40.80.30.3
Locomotion distance, session 32.02.34.9-1.41.91.5-1.6-1.0-1.01.62.0-1.92.20.71.11.1
Stereotopy head waving bouts, day 30.60.72.40.2-0.31.2-0.10.10.1-0.3-0.20.3-0.41.5-1.5-1.5
Stereotopy head waving duration, day 30.60.71.80.7-1.10.50.30.60.5-0.6-0.70.7-1.00.9-1.3-1.3
Locomotion velocity, session 70.20.20.7-0.20.80.60.0-0.1-0.10.10.4-0.20.50.4-0.9-0.8
Locomotion distance, session 70.10.10.6-0.10.80.20.30.10.20.00.3-0.10.5-0.5-0.5-0.5
Stereotopy head waving bouts, day 71.21.42.9-1.51.21.7-1.5-1.5-1.50.81.1-1.11.01.0-0.0-0.0
Stereotopy head waving duration, day 70.40.51.2-0.90.51.1-1.1-0.9-0.90.20.6-0.60.40.60.30.2
Locomotion velocity, session 82.93.56.1-2.22.51.2-1.9-2.1-2.01.92.2-2.12.30.71.21.2
Locomotion distance, session 83.34.710.3-2.43.21.8-2.2-2.2-2.11.92.7-2.53.00.30.90.9
Degree of sensitization distance1.01.02.00.7-1.0-0.71.10.50.5-1.0-1.21.2-1.3-0.3-1.4-1.4
Degree of sensitization stereotypy0.30.40.9-0.80.71.0-0.8-0.8-0.80.20.5-0.50.50.40.10.0
Conditioned locomotion4.45.214.0-2.22.0-0.5-1.4-2.1-2.13.72.2-2.42.1-0.93.03.0
Cocaine response after cond. corrected0.91.32.50.9-1.6-0.61.11.01.1-1.3-1.51.4-1.60.3-0.9-1.0
Cocaine response after cond. not corrected1.21.82.91.0-1.4-0.61.41.01.1-1.3-1.61.6-1.60.7-1.7-1.7
Cocaine response before conditioning0.30.31.60.20.40.30.40.10.10.20.00.10.11.0-1.2-1.2
Saline control response0.10.20.50.3-0.4-0.70.30.50.6-0.4-0.30.3-0.2-0.20.40.4
Bone: connectivity density0.10.20.8-0.00.30.9-0.70.00.1-0.10.5-0.50.60.20.40.4
Bone: cortical apparent density1.11.73.51.7-1.7-1.21.31.81.9-1.2-1.31.3-1.20.4-0.4-0.4
Bone: cortical area1.01.74.31.2-1.3-1.61.31.21.4-1.1-1.21.0-1.1-2.10.90.9
Bone: cortical porosity0.40.41.1-0.90.8-0.80.4-1.1-1.00.3-0.00.0-0.1-0.80.20.2
Bone: cortical porosity0.20.20.8-0.70.7-0.40.2-0.9-0.90.20.0-0.0-0.0-0.4-0.1-0.1
Bone: cortical thickness0.61.03.00.7-0.8-1.41.20.70.9-0.8-0.90.8-0.8-1.70.80.8
Bone: cortical thickness0.50.64.00.30.3-0.60.70.50.7-0.8-0.10.30.2-2.00.70.7
Bone: cortical tissue density1.01.63.41.6-1.7-1.01.21.81.8-1.1-1.31.3-1.20.6-0.5-0.5
Condit. Reinf. active minus inactive responses0.40.41.60.7-0.10.30.30.70.6-1.3-0.40.6-0.20.5-0.9-0.8
Condit. Reinf. active-inactive response ratio2.62.85.42.0-1.7-1.21.71.91.8-2.3-1.81.9-1.7-1.0-0.8-0.8
Condit. Reinf. active responses0.40.51.4-0.41.21.2-0.6-0.3-0.4-0.30.7-0.51.00.7-0.6-0.5
Condit. Reinf. inactive responses4.35.69.4-2.53.13.0-2.7-2.3-2.32.02.8-2.62.92.00.10.1
Incentive salience index mean1.41.83.21.8-1.2-0.41.21.71.7-1.8-1.21.4-1.10.4-1.2-1.2
Condit. Reinf. lever presses1.21.83.82.0-1.7-0.71.31.81.9-1.4-1.31.3-1.20.2-0.9-0.8
Condit. Reinf. active minus inactive responses0.91.43.6-1.01.21.9-1.1-1.1-1.10.81.0-0.90.91.7-1.1-1.1
Condit. Reinf. active-inactive response ratio0.40.72.3-0.40.51.2-0.3-0.5-0.50.20.2-0.10.11.4-1.5-1.5
Condit. Reinf. active responses1.31.93.0-1.21.51.7-1.5-1.3-1.31.61.6-1.51.41.6-0.1-0.1
Condit. Reinf. inactive responses0.10.20.5-0.00.2-0.1-0.3-0.00.00.60.5-0.50.50.00.70.7
Condit. Reinf. lever presses0.50.71.3-0.91.10.8-0.8-0.6-0.61.01.1-1.01.10.70.10.1
Condit. Reinf. lever reinforcers received1.21.72.6-1.31.51.6-1.4-1.2-1.21.51.5-1.41.41.4-0.1-0.1
Conditioned reinforcement - actives0.20.62.0-1.01.40.4-0.5-1.2-1.10.40.8-0.70.90.20.00.0
Conditioned reinforcement - inactives0.20.61.80.6-0.6-1.31.1-0.00.1-0.1-0.80.7-0.9-1.0-0.4-0.4
Conditioned locomotion0.40.61.7-0.91.20.7-0.5-1.3-1.10.20.6-0.50.60.1-0.6-0.6
Patch foraging indifference point 0 sec0.82.33.51.0-1.5-1.71.81.31.6-1.9-1.91.9-1.9-0.6-1.0-1.0
Patch foraging indifference point AUC0.20.62.10.7-0.30.50.50.70.7-0.6-0.40.5-0.30.7-1.4-1.4
Delay disc. indifference point, 0s delay0.60.73.4-0.40.5-1.41.0-0.5-0.4-0.8-0.60.7-0.5-1.90.00.0
Delay disc. indifference point, 16s delay1.21.76.8-0.20.4-1.80.6-0.9-0.6-0.1-0.1-0.0-0.0-2.62.32.2
Delay disc. indifference point, 2s delay0.30.41.6-0.30.2-1.10.5-0.5-0.40.1-0.20.1-0.2-1.30.90.8
Delay disc. indifference point, 24s delay1.22.07.01.0-1.0-2.61.50.60.9-0.1-0.90.7-0.9-1.92.01.9
Delay disc. indifference point, 4s delay1.21.24.80.4-0.2-2.11.5-0.20.1-0.6-1.11.0-1.1-2.20.50.5
Delay disc. indifference point, 8s delay1.01.66.80.2-0.3-2.21.5-0.3-0.0-1.3-1.31.2-1.2-2.60.40.4
Indifference point function ln k0.10.20.9-0.0-0.5-0.90.1-0.00.10.2-0.30.1-0.4-0.40.90.9
Indifference point function log k0.10.20.9-0.0-0.5-0.90.1-0.00.10.2-0.30.1-0.4-0.40.90.9
Patch foraging total patch changes 0 sec0.72.03.30.8-1.5-1.51.71.21.5-1.8-1.81.8-1.8-0.5-1.0-1.0
Patch foraging total patch changes 12 sec1.01.42.90.6-1.1-0.21.01.01.1-1.4-1.21.3-1.3-0.0-1.7-1.7
Patch foraging total patch changes 18 sec0.30.71.50.7-0.7-0.40.70.80.9-1.2-0.90.9-0.80.2-1.0-1.0
Patch foraging total patch changes 24 sec0.10.30.90.2-0.30.10.40.50.7-0.5-0.30.4-0.30.9-0.9-0.9
Patch foraging total patch changes 6 sec2.03.34.71.7-1.9-0.81.72.02.2-2.1-1.92.0-1.80.5-2.1-2.1
Patch foraging time to switch 0 sec0.00.10.50.5-0.30.00.10.70.5-0.1-0.10.2-0.00.4-0.4-0.4
Patch foraging water rate 0 sec0.00.20.6-0.80.3-0.0-0.2-0.8-0.50.00.1-0.20.1-0.30.50.4
Patch foraging water rate 12 sec0.00.20.70.0-0.00.8-0.20.30.3-0.40.00.00.10.8-0.6-0.6
Patch foraging water rate 18 sec0.30.62.00.4-0.31.4-0.50.40.5-0.60.10.00.11.4-1.1-1.1
Patch foraging water rate 24 sec0.20.30.80.2-0.30.80.20.50.4-0.6-0.30.4-0.30.7-0.9-0.9
Patch foraging water rate 6 sec0.10.10.5-0.40.50.7-0.3-0.4-0.1-0.20.2-0.20.3-0.3-0.1-0.1
Seeking ratio, delayed vs. immediate footshock0.00.00.3-0.50.1-0.1-0.3-0.1-0.1-0.10.1-0.10.1-0.30.10.1
Distance traveled before self-admin0.91.96.50.31.62.5-1.5-0.2-0.00.41.8-1.52.11.7-0.5-0.5
Distance traveled after self-admin0.30.51.90.50.60.60.10.20.4-0.40.2-0.00.40.9-1.4-1.3
Extensor digitorum longus weight0.31.22.7-0.81.61.3-0.8-0.8-1.11.01.3-1.11.51.1-0.6-0.6
Bone: elastic displacement4.25.39.2-2.62.41.8-2.5-2.7-2.83.02.5-2.62.31.41.21.2
Bone: elastic work2.02.74.7-2.12.11.4-1.5-2.2-2.11.81.7-1.71.60.80.30.3
Bone: endosteal estimation0.51.12.71.5-1.5-0.00.61.51.6-1.0-0.90.9-0.90.1-0.8-0.8
Bone: endosteal perimeter0.30.71.61.0-1.2-0.30.71.11.3-1.0-0.90.8-0.9-0.4-0.5-0.5
Epididymis fat weight0.94.67.41.9-2.2-2.72.71.81.8-1.9-2.62.5-2.5-2.2-1.1-1.1
Delta time in closed arm before/after self-admin0.50.52.20.2-0.0-0.50.10.00.40.10.1-0.20.2-1.31.51.5
Delta time in open arm before/after self-admin0.60.72.9-0.60.10.8-0.3-0.3-0.60.0-0.10.2-0.31.4-1.7-1.7
Diff in mean of infusions in LGA sessions0.40.82.5-0.40.1-0.1-0.6-0.6-0.51.50.7-0.90.5-0.41.61.6
Delay discount exponential model param1.31.88.40.1-0.12.5-1.30.70.30.50.8-0.70.72.9-1.6-1.6
Extinction: sum of active levers before priming0.40.61.40.6-1.0-0.40.70.30.2-0.5-1.00.9-1.20.3-0.9-1.0
Active lever presses in extinction session 60.10.10.60.10.10.2-0.10.10.1-0.10.1-0.00.10.7-0.8-0.8
Bone: final force0.81.31.91.1-1.3-1.21.41.11.3-1.3-1.31.3-1.3-1.2-0.1-0.1
Bone: final moment0.50.81.40.8-1.0-1.01.20.81.0-1.0-1.11.0-1.0-0.9-0.2-0.2
Food consumed during 24 hour testing period1.22.310.2-0.1-0.31.00.4-0.4-0.40.3-0.60.6-0.92.6-3.2-3.2
Glucose0.30.42.4-0.60.3-0.40.2-0.4-0.4-1.5-0.60.6-0.5-1.0-0.2-0.2
Heart weight11.017.727.9-5.04.45.3-5.2-4.9-4.83.94.3-4.33.93.9-0.6-0.6
Delay discount hyperbolic model param1.31.77.90.2-0.22.4-1.20.80.40.30.7-0.60.72.8-1.5-1.5
Intermittent access intake day 1-15 change0.00.10.4-0.30.50.6-0.1-0.6-0.3-0.30.2-0.10.1-0.0-0.2-0.2
Intermittent access intake escalation0.00.10.70.00.40.8-0.1-0.4-0.1-0.30.2-0.20.20.3-0.3-0.3
Intermittent access intake escalation 20.50.92.1-1.21.51.1-0.8-1.4-1.00.50.9-0.81.00.10.0-0.0
Intermitt. access day 1 inactive lever presses0.00.31.10.8-0.2-0.71.00.30.2-0.4-0.60.6-0.6-0.4-0.5-0.5
Intermitt. access day 15 inactive lever presses0.10.41.10.30.91.0-0.10.1-0.1-0.30.5-0.30.70.6-0.9-0.9
Intermitt. access escalation Index0.51.53.3-0.81.01.8-1.6-0.6-0.51.11.5-1.41.41.80.40.4
Intermittent access day 1 total infusions0.51.53.51.8-1.2-0.31.11.91.6-0.8-0.91.0-0.70.9-1.3-1.3
Intermittent access day 15 total infusions0.82.04.61.9-0.90.31.21.61.5-1.5-1.01.2-0.91.1-2.1-2.1
Intermittent access terminal intake (last 3 days)1.32.35.12.3-1.2-0.31.62.02.0-1.4-1.21.4-1.00.6-1.8-1.7
Intermittent access total infusions2.53.05.82.4-1.5-1.02.02.22.1-1.7-1.61.7-1.40.3-1.8-1.8
Intermittent access day 1 locomotion1.01.84.12.0-1.5-0.20.81.91.9-1.7-1.01.1-1.00.5-1.1-1.1
Intermittent access day 15 total locomotion0.20.71.81.4-0.60.40.60.80.9-1.0-0.60.7-0.50.2-1.2-1.2
Intermittent access total locomotion0.70.92.91.7-0.8-0.10.71.21.3-1.3-0.70.7-0.60.2-0.7-0.7
Intermittent access standard deviation0.00.20.60.20.3-0.50.70.0-0.0-0.4-0.30.4-0.10.0-0.8-0.8
Left kidney weight0.00.31.10.20.61.1-0.6-0.3-0.30.10.6-0.50.60.6-0.4-0.4
Right kidney weight0.00.10.4-0.20.40.1-0.4-0.5-0.4-0.10.3-0.30.3-0.60.40.4
Cocaine induced anxiety0.51.33.2-1.40.9-0.8-0.5-1.1-1.20.90.6-0.70.8-1.51.81.8
Post-drug Anxiety0.80.92.3-0.81.00.1-0.7-0.6-0.80.40.9-0.91.1-0.71.51.5
Baseline Anxiety0.30.62.41.1-0.30.90.11.11.0-0.40.10.00.11.5-0.5-0.5
Tail length0.52.55.32.3-1.5-2.01.91.72.0-1.1-1.31.3-1.1-1.90.50.5
Length with tail0.73.06.02.5-1.6-2.32.41.92.2-0.9-1.61.5-1.4-1.90.00.0
Length without tail0.10.51.6-0.00.4-1.00.5-0.3-0.21.30.3-0.30.3-1.20.80.8
Times rat made contact with spout0.50.63.80.10.10.80.00.20.20.40.1-0.00.11.9-1.2-1.2
Lifetime Intake2.02.55.12.3-1.2-0.81.81.91.8-1.7-1.41.5-1.20.5-1.8-1.8
Liver weight, left3.66.29.72.1-2.5-2.53.12.22.3-2.8-3.13.1-3.0-1.0-1.8-1.8
Liver weight, right4.27.313.62.5-2.2-2.13.32.52.6-3.7-3.13.3-2.9-1.2-2.2-2.3
Locomotor activity2.23.58.4-2.91.91.1-2.0-2.8-2.81.61.6-1.71.40.20.90.9
Locomotor testing distance1.02.54.7-2.21.81.8-2.0-1.9-1.91.21.6-1.61.61.10.10.1
Locomotor testing rearing0.20.63.10.10.11.2-0.40.20.1-0.30.2-0.10.21.8-1.1-1.2
Locomotion in novel chamber2.43.25.4-2.12.31.8-1.9-1.6-1.52.12.1-2.02.31.4-0.00.0
Locomotion in novel chamber post-restriction0.92.85.9-2.41.31.0-2.0-2.2-2.02.21.6-1.81.20.51.21.2
Fecal boli incidents, locomotor time 12.05.39.31.2-1.4-2.43.11.31.5-2.9-2.82.9-2.6-1.8-2.3-2.3
Change in fecal boli incidents, locomotor task1.61.65.6-0.80.61.1-1.3-1.3-1.22.41.3-1.51.01.50.90.9
Time >=10cm from walls, locomotor time 10.10.10.60.3-0.10.6-0.3-0.4-0.30.30.2-0.2-0.10.8-0.2-0.2
Bouts of movement, locomotor time 10.91.22.50.8-0.9-1.21.31.41.1-1.6-1.21.3-1.0-0.8-0.6-0.6
Total resting periods, locomotor time 11.11.22.81.1-1.0-1.21.31.71.3-1.4-1.11.2-0.8-0.7-0.3-0.3
Rest time, locomotor task time 10.60.91.4-1.01.11.2-1.2-0.6-0.90.91.1-1.01.21.10.10.1
Distance moved, locomotor task time 10.10.30.9-0.00.1-0.3-0.3-0.1-0.20.80.5-0.50.5-0.50.91.0
Vertical activity count, locomotor time 10.10.92.3-0.40.21.4-1.5-0.2-0.51.01.2-1.21.00.90.70.7
Time >=10cm from walls, locomotor time 20.30.81.61.2-1.3-0.20.81.20.9-0.7-0.90.9-1.00.4-0.6-0.6
Bouts of movement, locomotor time 20.10.30.50.6-0.6-0.70.60.40.7-0.5-0.70.6-0.7-0.30.00.0
Total resting periods, locomotor time 20.00.10.30.2-0.3-0.40.10.20.40.0-0.10.1-0.1-0.20.60.6
Rest time, locomotor task time 21.83.14.8-1.71.72.2-2.1-1.6-1.62.02.0-2.02.02.00.20.2
Distance moved, locomotor task time 20.20.30.50.6-0.4-0.70.70.70.4-0.2-0.40.5-0.4-0.7-0.2-0.2
Vertical activity count, locomotor time 20.10.10.4-0.30.10.6-0.6-0.1-0.40.30.4-0.30.30.3-0.2-0.2
Light reinforcement 10.20.72.8-0.50.10.9-0.3-0.3-0.3-1.1-0.40.5-0.40.6-1.7-1.6
Light reinforcement 20.00.00.2-0.1-0.1-0.1-0.1-0.10.00.40.1-0.10.1-0.40.00.0
Bone: marrow area0.40.92.21.4-1.4-0.10.51.31.5-1.0-0.80.8-0.8-0.1-0.7-0.6
Bone: maximum diameter0.81.64.41.5-1.3-1.41.11.31.6-1.2-1.00.9-0.9-2.10.80.8
Bone: maximum force0.71.32.51.5-1.3-0.91.41.31.6-1.2-1.21.2-1.1-0.7-0.3-0.2
Bone: maximum moment0.30.71.31.1-0.9-0.61.00.91.2-0.8-0.80.8-0.8-0.3-0.3-0.3
Mean time between licks in bursts0.10.82.00.9-1.4-0.20.41.21.2-1.3-1.00.9-1.0-0.4-0.4-0.3
Mean num. licks in bursts0.92.44.21.0-1.50.20.91.91.8-1.4-1.31.5-1.32.0-2.0-2.0
Cd content in liver0.00.00.10.1-0.2-0.00.0-0.0-0.10.1-0.10.1-0.20.1-0.1-0.1
Co content in liver0.30.40.8-0.70.90.6-0.3-0.8-0.80.50.5-0.50.50.3-0.4-0.4
Cu content in liver1.21.43.9-1.21.0-0.1-0.9-0.8-0.81.01.1-1.11.1-0.82.02.0
Fe content in liver0.40.51.20.70.20.5-0.50.60.50.30.8-0.71.0-0.51.11.1
K content in liver0.70.72.5-0.50.51.0-0.8-0.6-0.61.30.9-0.90.71.6-0.1-0.1
Mg content in liver0.10.10.60.8-0.6-0.00.10.40.4-0.1-0.20.1-0.30.30.20.1
Mn content in liver0.40.41.11.1-0.60.9-0.10.70.7-0.3-0.00.0-0.11.0-0.6-0.6
Na content in liver1.61.83.8-0.90.90.5-1.4-0.9-1.01.81.5-1.71.50.31.91.9
Rb content in liver0.30.40.90.0-0.00.7-0.70.10.10.90.7-0.70.60.90.70.6
Se content in liver0.91.12.91.7-1.4-0.60.81.61.7-1.0-0.80.8-0.80.00.40.4
Sr content in liver0.60.51.60.5-0.90.20.10.70.7-0.4-0.50.5-0.60.8-1.3-1.2
Zn content in liver1.51.73.10.6-0.8-1.81.80.40.4-1.6-1.71.7-1.7-1.7-0.7-0.7
Bone: minimum diameter1.52.85.62.4-2.2-1.11.62.12.3-1.7-1.71.6-1.7-0.8-0.3-0.4
Time in familiar zone, hab. session 10.30.31.0-1.00.70.3-0.5-0.7-0.80.70.5-0.50.5-0.10.10.1
Time in novel zone, hab. session 10.70.71.60.9-0.8-1.20.60.70.8-0.8-0.60.5-0.5-1.01.31.2
Total zone transitions, hab. session 10.30.51.70.10.40.4-0.50.20.31.30.9-0.80.90.90.40.4
Total locomotion distance, hab. session 10.30.41.2-0.60.70.4-0.0-0.4-0.41.10.5-0.40.50.7-0.7-0.7
Locomotion velocity, hab. session 10.50.71.5-0.80.90.7-0.3-0.6-0.61.20.6-0.50.51.2-1.1-1.1
Time in familiar zone, hab. session 20.80.92.4-0.60.51.4-1.6-0.7-0.60.91.1-1.20.91.30.20.2
Time in novel zone, hab. session 20.30.30.8-0.10.0-0.60.80.1-0.0-0.9-0.70.7-0.6-0.8-0.4-0.4
Total zone transitions, hab. session 22.43.06.4-0.81.91.9-2.1-1.1-1.01.92.4-2.32.51.11.11.1
Total locomotion distance, hab. session 21.52.04.0-1.22.01.8-1.4-1.4-1.21.31.7-1.51.81.3-0.7-0.7
Locomotion velocity, hab. session 21.01.42.8-0.91.71.6-1.1-1.1-0.91.01.3-1.11.41.2-0.9-0.9
Novel to familiar place preference ratio0.40.51.00.5-0.5-0.20.80.80.8-1.0-0.70.8-0.60.4-1.0-1.0
Novelty place preference0.30.41.00.4-0.4-0.20.60.70.7-1.0-0.60.7-0.50.3-0.8-0.8
Time in novel zone, NPP test0.30.40.90.4-0.4-0.20.60.70.6-0.9-0.70.7-0.60.3-0.7-0.7
Total zone transitions, NPP test2.02.95.4-1.62.10.4-1.3-1.7-1.62.32.0-1.92.0-0.11.71.7
Total locomotion distance, NPP test1.52.14.3-1.52.11.2-0.9-1.6-1.52.01.5-1.31.51.2-0.9-0.9
Locomotion velocity, NPP test1.52.14.9-1.62.21.1-0.9-1.7-1.62.01.5-1.31.51.0-0.8-0.8
Intraocular pressure0.30.52.10.5-0.10.30.40.80.7-1.5-0.50.6-0.20.5-0.9-1.0
Delta distance traveled before/after self-admin0.60.62.80.1-0.5-1.71.30.20.30.1-1.00.9-0.9-0.6-0.4-0.4
Delta ambulatory time before/after self-admin0.50.92.30.3-0.9-1.51.50.50.50.1-1.21.1-1.2-0.1-0.9-0.9
Parametrial fat weight2.14.914.51.6-1.2-0.72.31.41.2-2.4-2.32.5-2.1-0.0-3.8-3.8
Pavlov. Cond. lever latency0.30.40.8-0.60.90.6-0.7-0.4-0.60.40.8-0.70.90.40.50.5
Pavlov. Cond. magazine entry latency1.21.53.31.7-1.8-0.40.81.41.6-1.6-1.31.2-1.4-0.4-0.6-0.6
Pavlov. Cond. change in total contacts0.20.20.40.6-0.5-0.10.30.40.6-0.6-0.40.4-0.4-0.6-0.1-0.1
Pavlov. Cond. index score1.31.63.21.5-1.8-1.11.21.31.5-1.4-1.41.3-1.4-1.1-0.3-0.3
Pavlov. Cond. latency score0.81.02.01.1-1.4-1.00.90.91.1-1.0-1.11.0-1.2-1.1-0.1-0.0
Pavlov. Cond. lever contacts0.70.81.21.0-1.1-0.61.00.91.1-0.9-1.11.0-1.0-0.4-0.8-0.8
Pavlov. Cond. magazine entry number0.81.02.6-1.61.40.4-0.7-1.4-1.51.20.9-0.90.90.50.40.4
Pavlov. Cond. intertrial magazine entries0.80.93.6-1.21.90.6-0.2-1.4-1.30.60.8-0.60.90.2-0.8-0.8
Pavlov. Cond. lever-magazine prob. diff.1.62.03.81.7-1.9-1.21.31.51.7-1.4-1.61.5-1.6-1.2-0.3-0.3
Pavlov. Cond. response bias1.01.32.61.6-1.5-0.10.81.31.5-1.1-1.11.0-1.10.2-1.1-1.1
Pavlov. Cond. lever latency1.52.04.21.2-1.7-2.01.51.00.9-1.5-1.71.5-1.7-1.80.50.4
Pavlov. Cond. magazine entry latency0.20.30.90.2-0.10.20.20.20.3-0.6-0.30.4-0.30.9-0.9-0.9
Pavlov. Cond. change in total contacts0.20.61.9-0.10.41.3-0.70.10.20.40.6-0.50.71.4-0.9-0.9
Pavlov. Cond. index score0.30.52.3-0.20.51.1-0.5-0.1-0.00.30.5-0.40.51.5-0.9-0.9
Pavlov. Cond. latency score0.30.42.0-0.20.51.0-0.5-0.00.10.30.5-0.40.61.4-0.7-0.7
Pavlov. Cond. lever contacts1.32.03.8-1.21.61.9-1.5-1.0-0.91.51.6-1.51.71.9-0.4-0.4
Pavlov. Cond. magazine entry number0.10.10.70.2-0.1-0.40.20.20.10.10.0-0.00.0-0.80.60.5
Pavlov. Cond. intertrial magazine entries0.41.02.11.1-1.1-0.40.81.11.0-1.5-1.11.1-1.0-0.2-0.9-0.9
Pavlov. Cond. lever-magazine prob. diff.0.30.42.0-0.10.41.1-0.5-0.00.10.20.4-0.30.51.4-0.9-0.9
Pavlov. Cond. response bias1.01.43.6-1.11.31.7-1.1-1.0-0.91.11.2-1.01.21.9-0.7-0.7
Time in closed arm before self-admin0.30.52.10.5-0.20.50.10.80.6-1.4-0.30.5-0.20.1-1.2-1.1
Time in closed arm after self-admin1.01.26.80.7-0.6-1.20.60.80.8-0.9-0.50.4-0.3-2.61.31.3
Time in open arm before self-admin0.81.02.7-1.10.6-0.6-0.3-1.6-1.31.60.5-0.70.2-0.71.21.2
Time in open arm after self-admin1.92.15.2-1.81.01.6-1.2-1.7-1.91.50.8-0.80.42.3-1.4-1.4
Bone: periosteal estimation0.92.04.11.8-1.9-1.21.31.72.0-1.3-1.41.3-1.4-1.30.10.1
Bone: periosteal perimeter0.40.91.70.8-1.2-0.80.70.91.1-1.1-1.00.9-1.0-1.30.40.4
Bone: post-yield work1.11.93.71.9-1.4-1.01.61.51.7-1.3-1.51.5-1.40.1-1.0-1.0
Progressive ratio test 1 active lever presses0.30.51.81.3-0.4-0.00.51.20.9-0.3-0.10.20.11.0-0.6-0.6
Progressive ratio test 1 breakpoint0.30.61.81.4-0.5-0.00.51.21.0-0.3-0.10.20.01.1-0.7-0.7
Progressive ratio test 1 inactive lever presses0.20.41.71.3-0.4-0.71.10.90.70.2-0.30.4-0.30.2-0.4-0.4
Progressive ratio test 2 active lever presses1.31.85.22.3-1.1-0.81.52.01.9-1.2-0.91.1-0.70.1-1.1-1.1
Progressive ratio test 2 breakpoint1.41.85.12.3-1.1-0.81.52.01.9-1.2-0.91.1-0.70.1-1.0-1.0
Progressive ratio test 2 inactive lever presses0.31.13.01.7-0.7-0.81.51.31.2-0.4-0.80.9-0.6-0.1-1.1-1.1
Incentive Sensitization - Responses0.30.82.21.5-0.9-1.21.21.21.3-0.3-0.70.7-0.6-0.8-0.0-0.0
Incentive Sensitization - Breakpoint0.40.92.31.5-0.9-1.31.21.31.3-0.4-0.70.8-0.6-0.90.10.1
Sum of active levers in priming session hrs 5-60.10.10.50.3-0.1-0.10.00.10.0-0.7-0.20.2-0.1-0.40.20.2
Progressive ratio0.10.20.9-0.20.1-0.2-0.1-0.1-0.20.80.4-0.50.3-0.10.90.9
Food seeking constrained by brief footshock1.72.13.8-1.52.01.9-1.6-1.0-1.30.91.7-1.51.91.6-0.3-0.3
Seeking ratio, punishment vs. effort0.20.40.9-0.60.90.9-0.7-0.4-0.40.00.6-0.40.80.8-0.6-0.6
Retroperitoneal fat weight0.10.62.50.4-0.41.0-0.10.80.5-0.5-0.10.2-0.10.9-1.6-1.6
Reaction time number correct0.10.51.0-0.6-0.10.8-0.2-0.8-0.90.1-0.20.1-0.51.0-1.0-1.0
Reaction time mean minus median0.32.23.21.6-1.7-1.51.71.31.5-1.7-1.81.7-1.7-0.8-0.5-0.5
Reaction time mean minus median AUC0.00.20.30.5-0.6-0.30.40.50.6-0.5-0.50.5-0.5-0.0-0.2-0.3
Reaction time num false alarms0.50.82.80.8-0.71.4-0.40.90.7-0.7-0.10.1-0.11.7-1.3-1.2
Reaction time num false alarms AUC0.30.83.40.2-0.01.8-1.00.20.1-0.10.5-0.50.41.8-0.9-0.9
Reaction time trials correct on left0.10.51.0-0.6-0.10.8-0.2-0.8-0.90.1-0.20.1-0.51.0-1.0-1.0
Reaction time trials on left0.10.51.1-0.6-0.10.8-0.2-0.7-0.80.0-0.30.2-0.61.0-1.1-1.1
Reaction time mean0.61.33.40.9-1.4-1.81.20.70.7-1.2-1.51.3-1.5-1.10.30.3
Reaction time mean AUC0.61.33.20.9-1.4-1.81.20.70.8-1.2-1.51.3-1.5-1.00.30.2
Median of all reaction times0.61.02.80.5-1.1-1.71.00.40.4-1.1-1.31.1-1.3-1.10.40.3
Reaction time omissions0.20.30.80.5-0.9-0.70.70.50.5-0.1-0.70.6-0.8-0.3-0.2-0.2
Reaction time false alarm rate0.30.41.30.6-0.11.1-0.60.60.6-0.10.5-0.40.51.1-0.4-0.3
Reaction time premature initiation rate1.52.33.41.0-1.7-0.81.41.51.8-1.9-1.81.8-1.70.2-1.6-1.6
Reaction time premature initiations0.72.03.30.7-1.6-0.61.31.01.2-1.8-1.81.7-1.80.3-1.7-1.7
Std. dev. reaction times0.72.23.41.6-1.8-1.71.61.31.5-1.6-1.81.7-1.8-1.0-0.4-0.4
Reaction time trials completed0.10.51.1-0.6-0.10.8-0.2-0.7-0.80.0-0.30.2-0.61.0-1.1-1.1
Reaction time trials AUC0.10.51.2-0.6-0.20.7-0.1-0.7-0.8-0.1-0.40.3-0.71.0-1.1-1.1
Run reversals in cocaine runway, females1.71.97.0-0.51.2-0.2-0.8-1.2-0.60.81.2-1.41.2-1.22.62.6
Run reversals in cocaine runway, males1.21.33.5-0.71.11.9-1.4-0.8-0.41.21.4-1.21.31.6-0.4-0.4
Latency to leave start box in cocaine runway0.00.10.3-0.0-0.0-0.50.2-0.1-0.2-0.2-0.20.1-0.2-0.30.40.4
Latency to leave start box in cocaine runway, F0.20.20.60.4-0.1-0.60.70.50.1-0.8-0.50.6-0.4-0.2-0.3-0.3
Latency to leave start box in cocaine runway, M0.90.92.8-0.60.2-0.3-0.6-1.1-0.61.20.6-0.90.4-0.61.71.7
Std. dev. time between licks in bursts0.51.01.9-1.30.70.6-1.3-1.4-1.31.00.9-1.00.7-0.11.01.0
Total sessions with >9 infusions0.30.41.31.1-0.4-0.00.50.90.7-0.6-0.20.3-0.10.5-0.7-0.7
Short access day 1 total inactive lever presses0.10.10.50.70.3-0.30.60.40.4-0.5-0.00.10.2-0.3-0.2-0.2
Short access day 10 total inactive lever presses0.00.31.3-0.20.2-0.80.4-0.6-0.60.2-0.20.1-0.2-1.10.70.7
Short access day 1 total infusions0.30.62.61.6-0.50.40.31.21.0-0.8-0.00.10.00.8-0.5-0.5
Short access day 10 total infusions0.61.12.01.1-1.0-0.41.01.11.0-0.7-0.90.9-0.91.1-1.4-1.4
Short access total infusions0.60.91.91.4-0.7-0.61.11.21.0-0.9-0.70.8-0.60.4-1.1-1.1
Short access day 1 locomotion0.10.20.60.8-0.50.00.30.60.70.1-0.10.1-0.20.7-0.4-0.3
Short access day 10 total locomotion0.10.61.1-0.30.60.7-1.0-0.5-0.30.20.9-1.00.90.11.01.0
Short access total locomotion0.10.10.40.30.00.6-0.30.10.2-0.30.2-0.20.20.5-0.4-0.4
One hour access (0.3 mA shock)0.70.82.01.4-0.7-0.71.20.81.0-0.7-0.90.9-0.8-0.3-0.9-0.9
Compulsive drug intake0.81.22.4-1.41.11.3-1.5-1.0-1.01.11.3-1.31.30.80.40.3
One hour access (shock baseline)0.82.24.51.9-1.0-1.32.11.31.5-1.4-1.51.6-1.4-0.4-1.5-1.5
Social response proportion0.40.51.20.90.1-0.60.30.90.90.50.5-0.30.7-0.51.11.1
Social responses0.20.21.0-0.10.50.10.0-0.1-0.01.00.6-0.50.7-0.10.60.6
Social time0.30.51.4-1.00.90.5-0.6-1.2-0.90.70.5-0.50.50.5-0.3-0.3
Soleus weight0.30.92.2-0.91.21.2-0.5-0.8-0.90.20.6-0.40.70.9-1.5-1.4
Bone: stiffness1.63.05.52.2-2.2-1.01.82.12.4-1.7-1.81.8-1.8-0.5-1.0-1.0
Tibialis anterior weight0.20.62.20.6-0.2-0.10.80.60.3-0.5-0.60.7-0.40.4-1.5-1.5
Time to tail flick, vehicle, before self-admin1.11.42.3-1.01.21.2-1.5-1.1-0.90.61.4-1.41.40.41.41.4
Time to tail flick, vehicle, after self-admin0.10.20.5-0.50.7-0.4-0.1-0.7-0.60.20.3-0.40.5-0.30.10.2
Time to tail flick, test, before self-admin2.22.67.1-1.21.4-0.4-1.1-1.7-1.51.41.3-1.51.3-1.32.72.7
Time to tail flick, test, after self-admin2.93.15.0-1.62.11.6-2.0-2.2-1.91.62.0-2.11.90.21.31.3
Delta time to tail flick, vehicle, before/after SA1.11.12.40.5-0.7-1.31.40.40.5-0.8-1.31.3-1.3-0.2-1.5-1.5
Delta time to tail flick, test, before/after SA0.30.31.10.00.31.0-0.4-0.3-0.1-0.10.2-0.10.21.0-0.9-0.9
Tibia length0.92.46.02.3-2.1-1.11.42.42.3-1.1-1.31.3-1.2-0.60.10.1
Ambulatory time before self-admin0.51.64.90.11.52.2-1.4-0.2-0.10.51.8-1.52.01.4-0.2-0.2
Ambulatory time after self-admin0.60.94.10.60.30.80.10.30.4-0.50.00.20.21.3-2.0-2.0
Bone: tissue strength0.20.21.50.1-0.10.00.1-0.3-0.30.6-0.10.0-0.31.2-0.3-0.3
Total heroin consumption0.20.20.4-0.30.6-0.4-0.2-0.4-0.30.60.5-0.50.50.20.70.7
Bone: trabecular number0.20.40.7-0.40.50.8-0.8-0.4-0.50.40.7-0.70.7-0.20.60.6
Bone: trabecular spacing0.20.31.4-0.2-0.3-1.10.5-0.2-0.1-0.4-0.60.5-0.6-1.20.10.1
Bone: trabecular thickness0.10.10.2-0.30.40.3-0.1-0.3-0.30.10.2-0.10.20.5-0.3-0.3
Bone: trabecular tissue density0.40.82.00.7-0.6-1.40.90.50.6-1.2-1.00.9-0.8-1.30.30.3
Water consumed over 24 hours0.71.34.80.10.21.5-0.3-0.3-0.1-0.10.10.0-0.02.2-2.1-2.1
Number of responses in last shaping day0.20.30.80.6-0.5-0.90.6-0.10.00.1-0.50.4-0.6-0.7-0.5-0.4