Hub : Genes

Phospho1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative TSS NM_001105833.1 0.02 0.02 4.2e-03 0.02 0.02 0.02 0.02 4.0e-03 5.8e-03 5.4e-03 4.8e-03
2 PL alternative TSS XM_006247184.5 0.02 0.02 5.9e-03 0.02 0.01 0.01 0.01 2.7e-03 1.1e-02 9.0e-03 9.0e-03
3 IC gene expression Phospho1 0.07 0.05 2.3e-03 0.05 0.01 0.02 0.03 5.2e-03 7.2e-02 3.4e-02 2.6e-02
4 BLA gene expression Phospho1 0.07 0.05 2.6e-04 0.05 0.06 0.05 0.05 8.9e-04 3.8e-04 1.9e-03 1.3e-03
5 Liver alternative TSS XM_006247184.5 0.02 0.01 6.6e-03 0.01 0.01 0 0 3.6e-02 3.5e-02 2.4e-01 8.8e-02
6 Liver alternative TSS NM_001105833.1 0.02 0.01 6.1e-03 0 0.01 0 0 8.7e-02 3.6e-02 2.8e-01 1.1e-01
7 PL gene expression Phospho1 0.06 0.07 1.2e-03 0.02 0.02 0.02 0.02 3.7e-03 1.9e-03 1.1e-03 5.1e-03
8 BLA mRNA stability Phospho1 0.08 0.05 7.5e-05 0.08 0.07 0.07 0.07 3.9e-05 1.0e-04 9.1e-05 1.3e-04
9 Liver mRNA stability Phospho1 0.2 0.1 0.0e+00 0.15 0.16 0.15 0.16 1.2e-16 1.5e-17 1.8e-16 8.0e-17
10 NAcc mRNA stability Phospho1 0.03 0.02 9.9e-07 0.04 0.04 0.04 0.04 1.9e-07 7.3e-07 2.4e-06 1.9e-06
11 Liver gene expression Phospho1 0.48 0.09 0.0e+00 0.6 0.62 0.62 0.62 1.5e-84 2.3e-87 7.9e-87 1.3e-87
12 Brain mRNA stability Phospho1 0.12 0.11 5.7e-07 0.07 0.07 0.07 0.07 1.9e-07 2.3e-07 5.2e-07 3.4e-07
13 pVTA mRNA stability Phospho1 0.04 0.03 6.3e-05 0.03 0.04 0.03 0.03 2.0e-03 2.6e-04 1.3e-03 3.3e-03
14 Adipose mRNA stability Phospho1 0.09 0.06 4.0e-08 0.06 0.06 0.06 0.06 1.2e-07 2.3e-07 3.3e-07 2.0e-07
15 PL mRNA stability Phospho1 0.08 0.05 7.4e-12 0.1 0.11 0.1 0.11 1.6e-11 3.5e-12 2.4e-11 4.0e-12
16 Adipose gene expression Phospho1 0.44 0.2 0.0e+00 0.29 0.29 0.29 0.29 5.7e-32 3.2e-32 5.2e-32 3.4e-32
17 IC mRNA stability Phospho1 0.05 0.04 9.8e-03 0.02 0.05 0.03 0.03 3.7e-02 3.7e-03 1.8e-02 3.0e-02
18 IL mRNA stability Phospho1 0.13 0.1 8.7e-03 0.08 0.06 0.01 0.04 5.6e-03 1.2e-02 2.3e-01 4.3e-02
19 Brain gene expression Phospho1 0.15 0.11 3.6e-10 0.1 0.11 0.11 0.11 8.7e-10 8.9e-11 1.8e-10 2.9e-10
20 BLA isoform ratio NM_001105833.1 0.07 0.05 4.2e-04 0.02 0.05 0.04 0.04 3.1e-02 1.4e-03 5.7e-03 4.7e-03
21 BLA isoform ratio XM_006247184.5 0.07 0.05 5.2e-04 0.02 0.05 0.04 0.04 3.7e-02 1.5e-03 2.5e-03 5.4e-03
22 pVTA isoform ratio XM_006247184.5 0.03 0.03 7.5e-03 0.01 0.02 0.01 0.01 3.6e-02 1.1e-02 2.0e-02 4.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bone: apparent density1.11.92.9-1.71.71.71.51.5-1.51.31.4-1.41.4-1.41.31.4-1.41.3-1.21.21.4-1.1-1.11.11.1
Area under the delay curve0.00.10.40.1-0.1-0.2-0.3-0.30.2-0.6-0.40.2-0.20.10.0-0.20.2-0.20.2-0.2-0.30.10.1-0.1-0.1
BMI with tail18.162.580.2-9.09.08.28.68.6-8.58.78.1-8.28.0-8.18.08.0-7.97.8-7.97.07.2-6.7-6.76.76.4
BMI without tail1.54.67.0-2.62.62.32.42.4-2.42.42.2-2.42.1-2.32.02.1-2.32.1-2.21.71.7-1.7-1.61.61.5
Body weight1.14.97.2-2.72.72.12.22.3-2.32.11.9-1.62.0-1.91.82.3-2.12.2-2.02.52.2-2.1-2.42.42.6
Weight adjusted by age0.10.20.40.7-0.7-0.2-0.4-0.50.5-0.4-0.10.4-0.60.5-0.5-0.50.1-0.40.4-0.5-0.20.30.5-0.5-0.6
Bone surface0.40.81.4-1.11.11.00.90.9-0.90.80.8-0.60.7-0.80.70.9-1.10.8-0.70.91.2-0.8-0.80.90.9
Bone volume1.11.92.6-1.61.61.51.41.4-1.41.31.3-1.01.3-1.21.11.4-1.41.3-1.11.51.6-1.3-1.41.41.5
Breakpoint value in progressive ratio session2.02.43.21.8-1.8-1.8-1.6-1.71.7-1.3-1.61.3-1.51.5-1.4-1.61.2-1.51.2-1.6-1.31.51.6-1.6-1.6
Number of licking bursts1.01.62.21.0-1.0-1.1-1.1-1.11.1-1.0-1.21.2-1.41.4-1.4-1.31.3-1.31.4-1.4-1.31.51.4-1.4-1.4
Context. condit. distance diff. score1.01.22.0-1.11.11.11.11.1-1.11.21.2-1.00.9-1.01.01.0-1.31.1-1.10.91.4-1.0-0.90.90.9
Locomotion velocity, session 10.10.10.20.1-0.1-0.2-0.2-0.20.2-0.3-0.10.1-0.40.3-0.5-0.30.3-0.30.4-0.4-0.30.40.4-0.4-0.5
Locomotion distance, session 14.96.17.22.3-2.3-2.6-2.5-2.52.5-2.7-2.62.6-2.72.6-2.7-2.52.3-2.52.6-2.4-2.02.42.4-2.4-2.3
Locomotion velocity, session 20.81.01.51.2-1.2-1.2-1.2-1.21.1-1.2-1.11.2-1.21.1-0.9-1.00.8-0.90.9-0.7-0.50.60.6-0.6-0.5
Locomotion distance, session 26.69.29.93.0-3.0-3.1-3.1-3.13.1-3.2-3.12.9-3.13.0-3.0-3.13.2-3.13.1-3.0-2.83.03.0-3.0-3.0
Locomotion velocity, session 30.70.81.7-0.50.50.40.70.7-0.70.70.7-0.70.8-0.91.00.8-1.30.9-1.11.01.3-1.2-1.11.11.1
Locomotion distance, session 30.91.01.61.2-1.2-1.2-1.1-1.11.1-1.3-1.10.9-0.90.9-0.9-1.00.9-1.00.8-0.9-0.70.80.9-0.9-0.9
Stereotopy head waving bouts, day 34.55.37.5-2.22.21.92.32.3-2.32.62.1-2.12.3-2.32.52.3-2.72.3-2.42.32.4-2.2-2.32.32.3
Stereotopy head waving duration, day 33.54.15.6-2.02.01.82.02.0-2.02.22.0-1.71.9-1.92.02.0-2.42.0-2.02.12.1-2.0-2.12.12.2
Locomotion velocity, session 71.21.32.31.1-1.1-1.3-1.3-1.21.2-1.3-1.41.5-1.31.3-1.3-1.11.2-1.21.3-0.8-1.01.00.8-0.8-0.6
Locomotion distance, session 76.68.310.72.7-2.7-3.1-3.0-2.92.9-3.0-3.23.3-3.13.0-3.1-2.83.1-3.03.1-2.5-2.62.82.5-2.5-2.3
Stereotopy head waving bouts, day 70.40.40.9-0.50.50.40.60.6-0.60.60.5-0.60.7-0.71.00.6-0.70.6-0.70.60.8-0.6-0.60.60.6
Stereotopy head waving duration, day 70.40.51.1-0.60.60.50.60.6-0.60.60.6-0.80.8-0.81.00.7-0.80.8-0.90.70.6-0.8-0.80.80.7
Locomotion velocity, session 80.80.91.9-0.60.60.80.90.8-0.80.81.0-1.11.0-1.01.10.9-1.41.0-1.20.81.3-1.0-0.80.80.8
Locomotion distance, session 80.60.81.10.9-0.9-0.9-0.9-0.90.9-0.9-0.80.8-1.00.9-0.9-1.00.6-0.90.8-1.0-0.30.91.0-1.0-1.0
Degree of sensitization distance0.40.40.90.4-0.4-0.7-0.6-0.60.6-0.5-0.70.9-0.80.8-0.9-0.50.9-0.70.9-0.4-0.70.70.4-0.4-0.3
Degree of sensitization stereotypy0.20.20.40.5-0.5-0.4-0.4-0.40.4-0.4-0.40.2-0.30.3-0.1-0.50.4-0.40.3-0.6-0.10.50.6-0.6-0.6
Conditioned locomotion1.41.72.8-1.41.41.71.41.4-1.41.11.6-1.31.2-1.11.01.4-1.01.3-1.11.30.9-1.3-1.31.31.2
Cocaine response after cond. corrected4.65.57.1-2.62.62.62.62.6-2.62.52.6-2.72.4-2.52.52.4-2.22.3-2.32.01.9-2.0-1.91.91.8
Cocaine response after cond. not corrected2.63.14.1-1.91.92.01.91.9-1.91.91.9-2.01.8-1.92.01.8-1.61.7-1.71.41.3-1.4-1.41.41.2
Cocaine response before conditioning2.42.83.61.8-1.8-1.9-1.8-1.81.8-1.7-1.91.8-1.71.7-1.5-1.71.4-1.71.6-1.6-1.51.51.5-1.5-1.5
Saline control response0.30.41.00.0-0.0-0.1-0.2-0.20.3-0.4-0.10.3-0.60.6-0.7-0.50.8-0.60.7-0.8-1.00.90.8-0.8-0.9
Bone: connectivity density0.30.40.8-0.90.90.90.70.7-0.70.50.6-0.70.6-0.70.60.6-0.80.6-0.60.40.9-0.5-0.30.30.3
Bone: cortical apparent density4.15.77.22.7-2.7-2.7-2.6-2.62.6-2.6-2.52.7-2.52.5-2.4-2.42.1-2.42.4-2.0-2.12.02.0-1.9-1.8
Bone: cortical area0.40.71.1-1.11.11.00.80.8-0.80.70.7-0.60.7-0.80.70.8-0.60.8-0.60.90.7-0.7-0.90.90.9
Bone: cortical porosity0.20.20.4-0.60.60.50.50.5-0.50.40.4-0.40.6-0.50.40.5-0.10.4-0.30.50.3-0.4-0.50.50.5
Bone: cortical porosity0.30.30.7-0.80.80.60.60.6-0.60.50.5-0.50.6-0.50.50.6-0.10.5-0.30.60.2-0.4-0.60.60.6
Bone: cortical thickness0.10.10.3-0.40.40.40.30.3-0.30.20.3-0.20.3-0.40.40.4-0.20.3-0.20.50.3-0.4-0.50.50.6
Bone: cortical thickness0.40.40.60.7-0.7-0.6-0.7-0.70.7-0.8-0.80.5-0.60.6-0.5-0.80.2-0.70.4-0.8-0.10.50.8-0.8-0.7
Bone: cortical tissue density4.86.58.12.8-2.8-2.9-2.8-2.82.7-2.8-2.72.8-2.72.7-2.6-2.62.3-2.52.5-2.2-2.32.22.1-2.1-1.9
Condit. Reinf. active minus inactive responses1.31.41.81.2-1.2-1.3-1.2-1.21.2-0.9-1.21.3-1.31.2-1.2-1.20.9-1.21.3-1.2-1.01.31.2-1.2-1.1
Condit. Reinf. active-inactive response ratio0.00.00.2-0.00.00.10.20.1-0.10.40.0-0.10.0-0.10.10.1-0.50.0-0.1-0.00.30.10.1-0.1-0.1
Condit. Reinf. active responses1.31.62.21.3-1.3-1.5-1.3-1.31.3-1.1-1.31.3-1.31.3-1.3-1.31.1-1.31.3-1.3-1.31.31.3-1.3-1.2
Condit. Reinf. inactive responses1.11.42.71.0-1.0-1.2-1.1-1.11.1-1.3-0.90.9-1.01.2-1.2-1.11.5-1.11.1-1.2-1.61.21.2-1.2-1.2
Incentive salience index mean2.22.73.01.7-1.7-1.7-1.6-1.61.6-1.5-1.61.5-1.71.7-1.7-1.71.4-1.71.6-1.7-1.51.71.7-1.7-1.7
Condit. Reinf. lever presses2.73.84.91.9-1.9-1.9-1.8-1.91.9-1.9-1.71.6-1.91.9-2.0-2.02.0-1.91.9-2.1-1.92.02.2-2.2-2.2
Condit. Reinf. active minus inactive responses0.30.40.90.1-0.1-0.3-0.4-0.40.4-0.5-0.50.3-0.40.6-0.6-0.60.9-0.60.7-0.8-1.00.90.9-0.9-0.9
Condit. Reinf. active-inactive response ratio0.60.62.30.1-0.1-0.3-0.3-0.40.4-0.4-0.40.0-0.40.5-0.6-0.71.0-0.80.7-1.2-1.21.21.3-1.3-1.5
Condit. Reinf. active responses0.20.20.4-0.10.1-0.2-0.3-0.30.3-0.5-0.40.4-0.40.5-0.6-0.40.6-0.50.6-0.5-0.60.60.5-0.5-0.5
Condit. Reinf. inactive responses0.00.00.2-0.10.10.1-0.1-0.00.0-0.1-0.10.3-0.10.1-0.10.1-0.20.10.10.30.3-0.3-0.40.40.5
Condit. Reinf. lever presses0.10.20.60.5-0.5-0.4-0.5-0.50.5-0.8-0.40.6-0.50.5-0.5-0.40.4-0.40.5-0.3-0.30.20.2-0.2-0.2
Condit. Reinf. lever reinforcers received0.20.30.50.0-0.0-0.3-0.4-0.40.4-0.6-0.50.5-0.50.6-0.7-0.50.7-0.60.7-0.6-0.70.70.6-0.6-0.6
Conditioned reinforcement - actives0.71.11.70.6-0.6-1.2-1.0-0.90.9-0.9-1.11.3-1.21.3-1.2-1.01.0-1.11.3-1.0-1.21.31.1-1.1-1.0
Conditioned reinforcement - inactives0.10.10.4-0.40.4-0.3-0.1-0.10.1-0.1-0.20.5-0.30.4-0.4-0.20.6-0.30.6-0.2-0.70.50.2-0.2-0.1
Conditioned locomotion0.10.20.6-0.80.80.40.50.5-0.50.40.6-0.50.2-0.20.10.4-0.10.3-0.20.2-0.10.0-0.10.10.0
Patch foraging indifference point 0 sec1.22.22.8-1.11.11.61.41.4-1.41.31.6-1.61.6-1.51.61.5-1.61.6-1.71.41.4-1.7-1.51.51.4
Patch foraging indifference point AUC0.00.00.10.1-0.1-0.1-0.2-0.20.2-0.2-0.10.2-0.10.2-0.1-0.10.2-0.10.2-0.00.10.0-0.00.00.0
Delay disc. indifference point, 0s delay0.10.20.80.0-0.00.0-0.3-0.30.3-0.6-0.30.3-0.50.4-0.5-0.30.6-0.30.5-0.3-0.90.30.3-0.3-0.3
Delay disc. indifference point, 16s delay1.31.42.3-1.11.10.91.11.1-1.10.81.0-1.31.3-1.31.51.1-1.41.2-1.41.11.1-1.3-1.11.11.1
Delay disc. indifference point, 2s delay0.20.20.50.1-0.1-0.1-0.4-0.40.3-0.7-0.30.6-0.60.5-0.7-0.30.6-0.40.6-0.1-0.60.30.1-0.1-0.1
Delay disc. indifference point, 24s delay0.40.40.90.6-0.6-0.8-0.7-0.70.7-0.6-1.00.7-0.60.6-0.4-0.70.4-0.70.5-0.6-0.90.60.6-0.6-0.6
Delay disc. indifference point, 4s delay1.21.32.51.2-1.2-1.2-1.3-1.31.3-1.6-1.41.4-1.11.2-1.1-1.11.1-1.11.2-0.8-1.20.80.7-0.7-0.6
Delay disc. indifference point, 8s delay0.10.10.20.2-0.2-0.3-0.2-0.30.2-0.5-0.40.1-0.10.10.1-0.20.3-0.20.1-0.2-0.40.20.2-0.2-0.2
Indifference point function ln k0.00.10.50.3-0.3-0.2-0.2-0.20.2-0.3-0.20.1-0.10.2-0.4-0.20.2-0.20.1-0.3-0.70.20.3-0.3-0.3
Indifference point function log k0.00.10.50.3-0.3-0.2-0.2-0.20.2-0.3-0.20.1-0.10.2-0.4-0.20.2-0.20.1-0.3-0.70.20.3-0.3-0.3
Patch foraging total patch changes 0 sec1.22.32.9-1.11.11.61.51.5-1.51.31.7-1.61.6-1.61.61.5-1.61.6-1.71.51.4-1.7-1.51.51.5
Patch foraging total patch changes 12 sec0.00.00.0-0.10.10.20.00.0-0.0-0.10.10.2-0.20.10.0-0.00.1-0.00.20.0-0.00.00.0-0.00.0
Patch foraging total patch changes 18 sec1.62.52.9-1.51.51.61.51.5-1.51.41.6-1.51.7-1.61.71.6-1.51.6-1.51.61.6-1.7-1.61.61.6
Patch foraging total patch changes 24 sec0.50.91.2-0.80.81.10.90.9-0.90.91.0-1.00.9-1.01.00.9-1.01.0-1.00.91.1-1.0-0.90.90.9
Patch foraging total patch changes 6 sec0.81.21.9-0.90.91.11.11.1-1.10.91.1-1.11.2-1.21.31.1-1.01.1-1.21.11.4-1.2-1.11.11.1
Patch foraging time to switch 0 sec0.10.20.50.3-0.3-0.3-0.4-0.50.5-0.4-0.50.5-0.70.4-0.3-0.50.2-0.60.6-0.60.10.60.6-0.6-0.6
Patch foraging water rate 0 sec1.63.34.0-1.71.71.51.81.8-1.81.81.8-1.82.0-1.81.81.8-2.01.9-2.01.81.9-1.8-1.81.81.8
Patch foraging water rate 12 sec0.40.91.5-0.80.80.50.90.9-0.90.90.7-1.01.2-0.90.80.9-1.21.0-1.11.01.1-1.1-1.01.01.0
Patch foraging water rate 18 sec0.00.00.00.1-0.1-0.00.00.0-0.00.10.10.1-0.00.1-0.20.00.00.0-0.00.1-0.2-0.0-0.10.10.1
Patch foraging water rate 24 sec1.21.62.4-1.21.21.21.31.3-1.31.51.3-1.21.4-1.21.11.3-1.41.3-1.31.21.2-1.2-1.21.21.2
Patch foraging water rate 6 sec0.10.10.5-0.20.2-0.00.30.3-0.20.20.2-0.70.6-0.30.20.1-0.60.3-0.6-0.10.2-0.20.1-0.1-0.3
Seeking ratio, delayed vs. immediate footshock2.32.84.1-1.91.92.01.71.7-1.71.72.0-1.21.2-1.51.51.7-1.41.6-1.21.71.9-1.6-1.71.71.7
Distance traveled before self-admin1.62.13.11.1-1.1-1.3-1.3-1.31.3-1.1-1.41.3-1.51.4-1.4-1.51.4-1.51.4-1.7-1.31.81.8-1.8-1.8
Distance traveled after self-admin0.10.10.5-0.40.40.00.20.2-0.20.1-0.1-0.30.3-0.20.1-0.1-0.4-0.1-0.1-0.50.70.30.5-0.5-0.6
Extensor digitorum longus weight1.04.15.7-2.02.01.91.91.9-1.91.91.9-1.71.9-1.91.92.0-2.42.0-2.02.12.4-2.1-2.12.12.2
Bone: elastic displacement0.00.00.3-0.00.00.10.20.2-0.20.40.2-0.20.2-0.10.10.1-0.50.2-0.30.10.3-0.1-0.10.10.1
Bone: elastic work0.00.00.1-0.20.20.00.00.0-0.00.00.20.2-0.20.1-0.2-0.0-0.2-0.00.10.00.10.0-0.00.00.1
Bone: endosteal estimation0.10.10.3-0.60.60.50.30.3-0.30.30.3-0.10.1-0.20.00.3-0.50.3-0.10.30.3-0.3-0.30.30.4
Bone: endosteal perimeter0.30.61.0-1.01.01.00.80.8-0.80.80.7-0.70.7-0.70.60.8-0.90.8-0.70.70.8-0.7-0.70.70.7
Epididymis fat weight0.10.31.5-1.21.20.40.60.7-0.60.70.3-0.30.3-0.40.30.40.10.2-0.10.2-0.10.1-0.10.10.1
Delta time in closed arm before/after self-admin0.30.30.8-0.50.50.60.40.5-0.50.60.4-0.10.4-0.30.30.6-0.30.5-0.30.80.3-0.5-0.80.80.9
Delta time in open arm before/after self-admin0.80.81.41.2-1.2-0.9-1.0-1.01.0-1.0-0.90.7-0.80.8-0.5-1.00.7-0.80.7-0.9-0.50.60.9-0.9-0.9
Diff in mean of infusions in LGA sessions1.72.12.81.2-1.2-1.4-1.4-1.41.4-1.0-1.61.5-1.71.5-1.5-1.51.2-1.61.4-1.5-1.11.71.6-1.6-1.5
Delay discount exponential model param0.10.10.5-0.30.30.40.40.4-0.40.70.6-0.40.4-0.30.10.4-0.30.3-0.30.30.4-0.2-0.20.20.2
Extinction: sum of active levers before priming1.21.42.50.9-0.9-1.0-1.2-1.21.2-1.0-1.21.6-1.61.3-1.5-1.11.2-1.21.4-0.9-1.41.10.9-0.9-0.8
Active lever presses in extinction session 60.30.31.1-0.20.20.30.40.4-0.40.70.3-0.70.6-0.60.70.3-1.00.5-0.80.20.7-0.4-0.20.20.1
Bone: final force0.10.10.6-0.80.80.60.40.5-0.50.30.4-0.20.2-0.20.20.3-0.00.20.00.2-0.00.0-0.10.10.2
Bone: final moment0.10.20.8-0.90.90.70.60.6-0.60.40.6-0.50.4-0.40.40.5-0.20.4-0.20.30.2-0.2-0.30.30.3
Food consumed during 24 hour testing period1.82.53.01.7-1.7-1.7-1.6-1.61.6-1.7-1.61.5-1.51.6-1.5-1.61.5-1.51.5-1.5-1.51.51.5-1.5-1.5
Glucose2.03.24.2-1.71.71.81.71.8-1.81.71.9-1.51.7-1.51.51.8-1.61.8-1.52.02.0-1.9-2.02.02.0
Heart weight0.60.92.0-1.41.41.11.11.1-1.11.30.8-0.60.8-0.90.81.0-0.70.8-0.61.00.9-0.6-0.90.90.9
Delay discount hyperbolic model param0.10.10.5-0.20.20.30.40.4-0.40.70.6-0.40.3-0.20.10.3-0.30.3-0.30.20.5-0.2-0.20.20.1
Intermittent access intake day 1-15 change0.00.10.20.4-0.4-0.2-0.2-0.20.2-0.5-0.1-0.2-0.10.1-0.1-0.30.2-0.20.0-0.40.00.10.4-0.4-0.4
Intermittent access intake escalation0.00.10.30.3-0.3-0.2-0.1-0.20.2-0.4-0.1-0.3-0.00.00.1-0.20.1-0.1-0.0-0.50.10.20.5-0.5-0.6
Intermittent access intake escalation 20.20.30.9-0.30.30.60.60.5-0.50.30.6-1.00.6-0.50.60.4-0.50.5-0.60.10.8-0.3-0.00.0-0.1
Intermitt. access day 1 inactive lever presses0.00.00.1-0.10.1-0.10.0-0.00.00.1-0.20.0-0.10.1-0.0-0.1-0.1-0.10.1-0.20.00.30.3-0.3-0.3
Intermitt. access day 15 inactive lever presses1.22.53.1-1.31.31.41.51.5-1.51.61.6-1.61.8-1.61.71.6-1.51.7-1.71.71.5-1.8-1.71.71.7
Intermitt. access escalation Index0.30.51.31.1-1.1-0.7-0.7-0.70.7-0.6-0.60.3-0.40.5-0.6-0.70.4-0.60.4-0.7-0.40.50.7-0.7-0.8
Intermittent access day 1 total infusions0.00.10.3-0.10.1-0.2-0.2-0.10.10.1-0.40.6-0.30.3-0.2-0.10.2-0.20.30.1-0.20.2-0.10.10.3
Intermittent access day 15 total infusions0.10.10.20.3-0.3-0.4-0.3-0.30.3-0.3-0.40.4-0.30.4-0.2-0.40.4-0.40.4-0.4-0.30.40.4-0.4-0.4
Intermittent access terminal intake (last 3 days)0.00.00.0-0.10.1-0.1-0.00.0-0.00.0-0.10.2-0.10.2-0.1-0.00.1-0.10.1-0.0-0.10.20.0-0.00.0
Intermittent access total infusions0.00.00.1-0.40.4-0.00.00.1-0.10.1-0.10.3-0.10.1-0.00.10.1-0.00.20.2-0.10.0-0.20.20.3
Intermittent access day 1 locomotion0.30.41.00.5-0.5-0.6-0.7-0.60.6-0.3-0.80.9-0.70.7-0.6-0.50.8-0.60.7-0.3-1.00.60.3-0.3-0.2
Intermittent access day 15 total locomotion0.20.40.90.4-0.4-0.7-0.6-0.60.6-0.6-0.70.8-0.80.7-0.8-0.50.9-0.70.8-0.4-1.00.60.4-0.4-0.3
Intermittent access total locomotion0.10.20.60.1-0.1-0.4-0.4-0.30.3-0.3-0.40.6-0.60.5-0.4-0.30.6-0.40.5-0.2-0.70.40.2-0.2-0.1
Intermittent access standard deviation0.40.81.2-1.01.01.01.01.0-1.00.81.0-1.10.9-0.90.90.9-0.70.9-0.90.80.7-0.9-0.80.80.7
Left kidney weight0.00.10.5-0.20.20.00.10.2-0.2-0.10.10.20.00.1-0.20.2-0.40.2-0.00.40.7-0.3-0.40.40.5
Right kidney weight0.31.42.3-1.31.31.11.21.2-1.31.01.4-0.91.0-0.90.81.3-1.11.2-1.01.31.5-1.2-1.31.31.3
Cocaine induced anxiety0.00.00.2-0.50.50.20.20.2-0.20.20.40.1-0.10.0-0.10.2-0.20.10.10.20.20.0-0.10.10.2
Post-drug Anxiety0.70.81.60.5-0.5-0.9-0.9-0.80.8-0.8-0.81.3-1.21.1-1.2-0.80.9-0.91.2-0.6-0.80.90.7-0.7-0.5
Baseline Anxiety0.91.11.51.2-1.2-1.2-1.2-1.21.2-1.1-1.21.1-0.91.0-0.9-1.01.1-1.01.0-0.8-1.00.80.8-0.8-0.6
Tail length16.765.382.59.0-9.0-8.6-8.8-8.88.7-9.1-8.58.6-8.28.4-8.3-8.27.8-7.97.9-7.1-7.16.86.8-6.8-6.4
Length with tail6.226.939.65.8-5.8-5.7-5.9-5.85.7-6.3-5.76.1-5.35.6-5.6-5.15.3-5.05.3-3.8-4.33.93.6-3.6-3.2
Length without tail0.30.93.2-0.90.90.60.60.7-0.70.30.50.10.6-0.40.61.0-0.50.8-0.41.51.2-1.1-1.61.61.8
Times rat made contact with spout0.80.92.31.0-1.0-1.1-0.9-0.90.9-1.0-0.91.0-0.90.9-0.9-0.81.5-0.91.1-0.7-1.41.00.7-0.7-0.7
Lifetime Intake0.00.00.1-0.20.20.10.10.1-0.10.20.00.10.0-0.00.20.1-0.10.1-0.00.2-0.0-0.1-0.20.20.3
Liver weight, left0.00.00.1-0.30.30.10.20.2-0.20.30.1-0.30.2-0.10.10.1-0.00.1-0.1-0.10.10.10.1-0.1-0.2
Liver weight, right0.10.10.50.2-0.2-0.4-0.3-0.30.3-0.3-0.60.7-0.50.4-0.3-0.2-0.1-0.30.3-0.0-0.10.20.0-0.00.1
Locomotor activity0.10.10.4-0.60.60.20.40.4-0.40.10.1-0.60.4-0.40.40.2-0.30.1-0.2-0.2-0.30.10.2-0.2-0.4
Locomotor testing distance0.40.71.8-1.31.30.91.01.0-0.90.70.9-1.30.9-1.00.90.7-0.60.6-0.70.2-0.2-0.3-0.10.1-0.1
Locomotor testing rearing0.10.10.4-0.60.60.40.30.3-0.20.00.3-0.50.2-0.20.2-0.0-0.3-0.0-0.1-0.5-0.40.30.5-0.5-0.7
Locomotion in novel chamber0.30.40.90.3-0.3-0.5-0.5-0.50.5-0.4-0.70.8-0.80.8-1.0-0.60.4-0.60.8-0.6-0.20.80.7-0.7-0.6
Locomotion in novel chamber post-restriction0.81.23.3-1.81.81.51.41.4-1.41.21.3-0.90.6-0.80.41.2-0.21.0-0.51.10.5-0.7-1.01.01.0
Fecal boli incidents, locomotor time 13.45.08.2-1.71.72.02.12.1-2.12.41.9-2.42.4-2.62.82.1-2.42.2-2.52.02.9-2.2-2.12.12.0
Change in fecal boli incidents, locomotor task2.52.53.41.3-1.3-1.7-1.6-1.51.5-1.5-1.71.8-1.51.8-1.7-1.61.5-1.71.7-1.5-1.41.71.5-1.5-1.4
Time >=10cm from walls, locomotor time 10.30.31.0-0.00.0-0.1-0.3-0.30.3-0.4-0.20.3-0.50.4-0.7-0.50.5-0.60.7-0.9-0.30.80.9-0.9-1.0
Bouts of movement, locomotor time 10.30.41.0-0.50.50.40.50.5-0.50.50.4-0.30.4-0.40.50.6-0.50.6-0.60.80.4-0.8-0.90.91.0
Total resting periods, locomotor time 10.80.91.7-0.90.90.70.80.9-0.91.00.8-0.60.7-0.70.91.0-0.81.0-1.01.20.8-1.1-1.21.21.3
Rest time, locomotor task time 10.20.30.5-0.40.40.50.50.5-0.50.60.6-0.70.6-0.40.50.60.00.6-0.50.60.1-0.6-0.60.60.6
Distance moved, locomotor task time 11.62.43.11.4-1.4-1.5-1.5-1.51.5-1.4-1.61.6-1.81.5-1.5-1.61.3-1.61.6-1.7-1.61.71.7-1.7-1.6
Vertical activity count, locomotor time 10.30.60.90.5-0.5-0.8-0.7-0.70.7-0.5-0.90.9-0.90.7-0.8-0.80.5-0.90.8-0.9-0.91.00.9-0.9-0.9
Time >=10cm from walls, locomotor time 20.40.50.80.6-0.6-0.6-0.6-0.60.6-0.7-0.80.6-0.80.6-0.8-0.70.7-0.70.7-0.8-0.80.90.8-0.8-0.9
Bouts of movement, locomotor time 20.00.00.2-0.20.20.3-0.00.0-0.0-0.20.20.3-0.50.4-0.2-0.00.1-0.10.3-0.0-0.30.20.1-0.1-0.0
Total resting periods, locomotor time 20.00.10.2-0.30.30.40.00.0-0.0-0.20.30.3-0.40.5-0.3-0.10.3-0.10.4-0.1-0.40.20.2-0.2-0.1
Rest time, locomotor task time 20.40.51.30.9-0.9-0.9-0.7-0.70.7-0.6-0.50.3-0.20.7-0.5-0.61.1-0.60.5-0.6-0.90.50.5-0.5-0.6
Distance moved, locomotor task time 20.10.10.40.4-0.4-0.4-0.4-0.40.4-0.5-0.60.6-0.60.3-0.4-0.3-0.1-0.30.3-0.1-0.30.20.1-0.10.0
Vertical activity count, locomotor time 20.10.10.5-0.00.0-0.2-0.3-0.20.2-0.4-0.50.7-0.50.3-0.5-0.2-0.1-0.30.4-0.1-0.10.30.1-0.1-0.0
Light reinforcement 10.00.10.6-0.20.20.20.30.2-0.20.10.3-0.70.4-0.40.40.1-0.10.1-0.3-0.3-0.20.10.3-0.3-0.5
Light reinforcement 20.30.40.90.5-0.5-0.4-0.6-0.60.6-0.6-0.40.3-0.60.4-0.5-0.70.8-0.60.7-0.8-0.70.70.8-0.9-1.0
Bone: marrow area0.00.10.2-0.50.50.40.20.3-0.30.20.3-0.00.0-0.1-0.00.3-0.40.2-0.10.30.3-0.2-0.30.30.3
Bone: maximum diameter0.40.71.1-1.01.01.00.90.9-0.90.90.8-0.90.9-0.90.80.8-0.90.8-0.80.70.8-0.7-0.70.70.6
Bone: maximum force0.50.91.8-1.31.31.10.91.0-1.00.80.9-0.60.7-0.80.71.0-0.80.8-0.61.00.8-0.8-1.01.01.0
Bone: maximum moment0.71.32.1-1.41.41.21.11.2-1.21.01.1-0.91.0-1.00.91.2-0.91.1-0.81.21.1-1.0-1.21.21.2
Mean time between licks in bursts0.51.32.1-1.41.41.31.11.2-1.21.11.2-0.91.0-1.00.81.3-0.41.1-0.81.40.4-1.2-1.41.41.4
Mean num. licks in bursts0.10.20.7-0.20.20.20.20.3-0.30.10.4-0.20.5-0.50.40.50.00.5-0.30.80.2-0.7-0.80.80.8
Cd content in liver0.10.10.40.0-0.0-0.0-0.1-0.10.1-0.30.00.0-0.20.2-0.5-0.30.6-0.30.5-0.5-0.60.50.5-0.5-0.6
Co content in liver0.00.00.00.0-0.0-0.20.0-0.00.0-0.00.1-0.10.10.00.1-0.10.1-0.10.1-0.2-0.10.20.2-0.2-0.2
Cu content in liver10.112.014.42.9-2.9-3.4-3.4-3.43.4-3.2-3.53.8-3.73.7-3.6-3.53.6-3.73.8-3.4-3.23.73.5-3.5-3.3
Fe content in liver1.31.63.30.8-0.8-0.8-1.2-1.21.2-1.1-1.21.8-1.71.5-1.5-1.21.3-1.41.7-1.1-1.21.41.1-1.1-1.0
K content in liver1.51.44.70.8-0.8-1.2-1.2-1.21.1-1.0-1.22.2-1.61.4-1.5-1.01.4-1.21.6-0.5-1.11.00.4-0.4-0.1
Mg content in liver7.37.413.52.2-2.2-2.7-2.8-2.72.7-2.6-2.93.7-3.23.0-3.2-2.63.0-2.93.3-2.1-2.62.72.1-2.1-1.8
Mn content in liver4.44.96.62.5-2.5-2.3-2.4-2.42.4-2.6-2.12.2-2.22.2-2.3-2.32.0-2.22.2-2.1-1.91.92.0-2.0-2.0
Na content in liver0.30.41.50.3-0.3-0.4-0.6-0.50.5-0.4-0.71.2-1.00.7-0.7-0.50.6-0.71.0-0.2-0.50.60.2-0.2-0.0
Rb content in liver1.11.32.10.6-0.6-1.4-1.0-1.01.0-0.9-1.21.0-1.01.1-1.1-1.11.0-1.21.1-1.4-0.81.41.4-1.4-1.4
Se content in liver0.10.10.3-0.40.40.60.40.4-0.40.40.4-0.30.2-0.30.10.3-0.00.3-0.20.2-0.1-0.1-0.20.20.2
Sr content in liver0.90.71.71.3-1.3-0.8-1.1-1.01.0-1.2-0.70.9-0.80.8-0.8-0.80.8-0.70.8-0.5-0.70.30.4-0.4-0.4
Zn content in liver0.50.61.40.3-0.3-0.5-0.6-0.50.6-0.4-0.71.2-0.90.9-0.9-0.61.0-0.91.1-0.6-0.71.00.7-0.7-0.6
Bone: minimum diameter0.10.10.4-0.60.60.30.20.2-0.20.10.10.20.0-0.1-0.00.3-0.10.20.00.50.1-0.3-0.50.50.6
Time in familiar zone, hab. session 10.20.20.60.2-0.2-0.2-0.3-0.40.4-0.4-0.30.3-0.50.4-0.4-0.50.6-0.50.5-0.7-0.30.70.7-0.7-0.8
Time in novel zone, hab. session 12.62.63.7-1.41.41.31.51.5-1.51.61.3-1.31.6-1.61.71.6-1.91.6-1.81.81.5-1.8-1.81.81.9
Total zone transitions, hab. session 16.99.611.13.0-3.0-3.3-3.1-3.13.1-3.2-3.32.9-3.13.0-3.0-3.13.2-3.13.1-3.1-2.83.13.1-3.1-3.1
Total locomotion distance, hab. session 14.36.17.12.3-2.3-2.6-2.5-2.52.5-2.4-2.72.4-2.52.4-2.4-2.52.5-2.62.5-2.5-2.22.52.5-2.5-2.4
Locomotion velocity, hab. session 15.67.99.12.6-2.6-2.9-2.8-2.82.8-2.8-2.92.8-2.92.8-2.9-2.83.0-2.93.0-2.8-2.62.92.8-2.8-2.7
Time in familiar zone, hab. session 21.41.42.5-1.11.11.11.31.2-1.21.31.2-1.61.5-1.41.41.2-1.31.2-1.40.91.2-1.1-0.90.90.8
Time in novel zone, hab. session 20.30.30.60.3-0.3-0.3-0.5-0.50.5-0.6-0.40.8-0.80.7-0.6-0.50.5-0.50.7-0.4-0.70.50.4-0.4-0.3
Total zone transitions, hab. session 24.76.06.92.3-2.3-2.4-2.4-2.42.4-2.5-2.42.3-2.42.4-2.5-2.52.6-2.52.5-2.5-2.22.52.5-2.5-2.5
Total locomotion distance, hab. session 21.21.52.10.9-0.9-1.3-1.2-1.21.2-1.2-1.41.3-1.31.3-1.4-1.21.4-1.31.4-1.2-1.11.41.2-1.2-1.1
Locomotion velocity, hab. session 21.31.82.31.1-1.1-1.4-1.3-1.31.3-1.4-1.51.4-1.41.4-1.5-1.31.5-1.41.5-1.2-1.11.41.2-1.2-1.2
Novel to familiar place preference ratio0.30.30.70.4-0.4-0.3-0.5-0.50.5-0.5-0.50.4-0.50.6-0.5-0.60.2-0.60.5-0.8-0.70.70.8-0.8-0.8
Novelty place preference0.20.20.50.3-0.3-0.2-0.4-0.40.4-0.4-0.40.3-0.50.5-0.4-0.50.1-0.50.4-0.7-0.60.60.7-0.7-0.7
Time in novel zone, NPP test0.10.10.40.2-0.2-0.1-0.2-0.20.3-0.2-0.30.1-0.20.2-0.1-0.4-0.2-0.30.2-0.6-0.30.40.6-0.6-0.6
Total zone transitions, NPP test6.39.012.12.9-2.9-2.9-3.0-3.03.0-3.3-2.92.5-2.92.9-3.0-3.03.5-3.03.0-3.1-3.22.93.0-3.0-3.1
Total locomotion distance, NPP test2.43.34.61.5-1.5-1.7-1.7-1.71.7-2.0-1.71.6-1.91.9-2.0-1.82.1-1.82.0-1.8-1.81.81.8-1.8-1.8
Locomotion velocity, NPP test2.94.15.61.8-1.8-1.9-2.0-2.02.0-2.3-2.02.0-2.12.1-2.3-2.02.4-2.02.2-1.9-2.02.01.9-1.9-1.8
Intraocular pressure1.01.51.91.3-1.3-1.1-1.3-1.31.3-1.4-1.41.1-1.11.2-1.3-1.21.2-1.21.2-1.2-1.31.11.1-1.1-1.1
Delta distance traveled before/after self-admin1.41.52.6-1.11.11.21.21.2-1.20.91.2-1.31.4-1.31.21.2-1.41.3-1.31.11.6-1.3-1.11.11.1
Delta ambulatory time before/after self-admin1.41.72.3-1.41.41.21.31.3-1.31.11.4-1.21.4-1.31.21.3-1.41.3-1.31.21.5-1.2-1.21.21.2
Parametrial fat weight0.10.20.4-0.60.60.30.40.4-0.40.40.3-0.10.3-0.30.50.4-0.20.4-0.20.50.5-0.3-0.50.50.5
Pavlov. Cond. lever latency1.51.93.6-1.31.31.21.21.2-1.31.41.0-0.81.2-1.31.31.4-1.51.4-1.31.71.4-1.5-1.71.81.9
Pavlov. Cond. magazine entry latency0.20.20.80.2-0.2-0.4-0.3-0.30.4-0.2-0.40.1-0.40.2-0.1-0.50.3-0.50.3-0.8-0.30.60.8-0.8-0.9
Pavlov. Cond. change in total contacts4.14.46.11.9-1.9-2.0-2.0-2.02.0-2.0-2.01.8-2.12.0-1.9-2.22.0-2.22.1-2.4-1.82.32.4-2.4-2.5
Pavlov. Cond. index score1.11.43.10.9-0.9-1.0-1.0-1.01.1-1.0-1.00.7-1.11.0-1.0-1.21.1-1.21.1-1.6-1.11.41.6-1.6-1.8
Pavlov. Cond. latency score1.11.42.91.0-1.0-1.0-1.0-1.11.1-1.0-0.90.7-1.11.1-1.0-1.21.1-1.21.1-1.5-1.01.41.6-1.6-1.7
Pavlov. Cond. lever contacts3.13.75.51.8-1.8-1.7-1.8-1.81.8-1.9-1.61.4-1.81.8-1.9-2.02.1-1.91.9-2.2-1.92.12.2-2.2-2.3
Pavlov. Cond. magazine entry number0.81.01.9-0.70.70.80.90.9-0.90.81.0-0.81.0-0.90.81.1-0.91.1-1.01.31.0-1.3-1.31.31.4
Pavlov. Cond. intertrial magazine entries1.31.52.61.0-1.0-1.3-1.2-1.21.2-1.3-1.11.5-1.41.4-1.6-1.11.5-1.21.5-0.9-1.31.20.9-0.9-0.8
Pavlov. Cond. lever-magazine prob. diff.1.11.33.10.9-0.9-1.0-1.0-1.01.0-1.0-0.90.6-1.01.0-0.9-1.21.1-1.21.0-1.6-1.01.41.6-1.6-1.8
Pavlov. Cond. response bias1.21.53.01.0-1.0-1.0-1.1-1.11.1-1.1-1.10.8-1.11.1-1.0-1.31.2-1.31.2-1.6-1.31.51.6-1.6-1.7
Pavlov. Cond. lever latency1.92.63.61.3-1.3-1.5-1.5-1.51.5-1.3-1.71.5-1.51.5-1.5-1.61.8-1.71.6-1.7-1.81.91.8-1.8-1.8
Pavlov. Cond. magazine entry latency0.20.20.80.9-0.9-0.6-0.6-0.50.5-0.6-0.30.6-0.40.4-0.4-0.20.3-0.20.30.2-0.2-0.2-0.20.20.3
Pavlov. Cond. change in total contacts0.60.91.7-0.70.70.90.80.8-0.80.61.0-0.91.0-0.90.90.9-1.11.0-1.01.11.1-1.3-1.11.11.2
Pavlov. Cond. index score0.60.81.6-0.50.50.70.70.7-0.70.60.9-0.60.8-0.80.80.9-1.11.0-0.91.21.1-1.2-1.21.21.3
Pavlov. Cond. latency score0.30.41.1-0.20.20.40.40.4-0.40.30.6-0.40.5-0.50.50.6-0.70.7-0.60.90.7-1.0-1.01.01.0
Pavlov. Cond. lever contacts1.62.23.1-1.21.21.41.41.4-1.41.21.7-1.41.5-1.41.41.5-1.71.6-1.61.61.7-1.7-1.61.61.6
Pavlov. Cond. magazine entry number0.20.31.4-0.00.0-0.1-0.1-0.20.2-0.2-0.3-0.2-0.10.1-0.1-0.50.5-0.50.3-1.0-0.60.91.0-1.0-1.2
Pavlov. Cond. intertrial magazine entries1.62.43.81.2-1.2-1.6-1.4-1.41.5-1.4-1.71.2-1.41.4-1.4-1.61.6-1.61.4-1.9-1.71.81.9-1.9-1.9
Pavlov. Cond. lever-magazine prob. diff.0.70.91.8-0.50.50.80.70.7-0.80.71.0-0.60.8-0.80.80.9-1.11.0-0.91.21.1-1.3-1.31.31.4
Pavlov. Cond. response bias1.52.02.8-1.11.11.31.31.3-1.31.21.5-1.21.3-1.31.21.4-1.61.5-1.41.61.6-1.7-1.61.61.7
Time in closed arm before self-admin3.03.85.1-2.22.22.02.02.0-2.01.71.8-1.71.9-2.01.91.9-2.11.9-1.81.92.3-1.8-1.91.91.9
Time in closed arm after self-admin3.53.85.5-2.42.42.01.92.0-2.01.81.7-1.21.8-1.81.52.0-1.81.8-1.52.22.1-1.8-2.22.22.3
Time in open arm before self-admin0.70.81.90.7-0.7-0.6-0.8-0.70.7-0.6-0.70.9-1.10.9-1.0-0.81.2-0.91.0-0.8-1.40.90.8-0.8-0.8
Time in open arm after self-admin2.22.43.61.9-1.9-1.5-1.6-1.71.7-1.5-1.51.1-1.51.5-1.2-1.61.6-1.51.3-1.6-1.61.31.6-1.6-1.6
Bone: periosteal estimation0.30.61.3-1.11.11.00.80.8-0.80.70.8-0.60.6-0.60.50.8-0.80.7-0.50.70.7-0.6-0.70.70.7
Bone: periosteal perimeter1.32.23.1-1.71.71.81.61.6-1.51.41.5-1.51.5-1.51.41.5-1.41.5-1.41.31.4-1.3-1.31.31.2
Bone: post-yield work0.91.41.9-1.21.21.01.11.1-1.11.01.1-0.91.1-1.01.01.2-1.21.2-1.11.31.4-1.3-1.31.31.4
Progressive ratio test 1 active lever presses1.11.42.11.2-1.2-1.2-1.2-1.11.1-1.1-1.01.1-1.21.3-1.3-1.21.2-1.21.2-1.1-1.41.21.1-1.1-1.1
Progressive ratio test 1 breakpoint0.91.11.61.0-1.0-1.1-1.0-1.01.0-0.9-0.91.0-1.01.1-1.2-1.01.0-1.01.0-1.0-1.31.01.0-1.0-1.0
Progressive ratio test 1 inactive lever presses0.30.51.1-0.70.70.70.80.8-0.80.80.8-1.10.9-0.80.80.6-0.70.7-0.80.40.4-0.5-0.40.40.3
Progressive ratio test 2 active lever presses0.91.11.70.4-0.4-0.9-0.9-0.80.8-0.9-1.01.3-1.21.2-1.3-0.91.1-1.11.3-1.0-1.21.31.0-1.0-0.9
Progressive ratio test 2 breakpoint0.91.01.70.4-0.4-0.8-0.8-0.80.8-0.8-1.01.2-1.11.2-1.3-0.91.1-1.11.3-1.0-1.11.31.0-1.0-1.0
Progressive ratio test 2 inactive lever presses0.00.10.4-0.60.60.10.10.2-0.20.20.10.2-0.10.2-0.30.10.1-0.10.30.0-0.10.30.0-0.00.0
Incentive Sensitization - Responses0.30.40.8-0.30.3-0.1-0.3-0.30.3-0.4-0.50.8-0.70.7-0.8-0.40.7-0.70.9-0.6-0.80.90.6-0.6-0.5
Incentive Sensitization - Breakpoint0.20.20.6-0.40.40.0-0.2-0.10.2-0.3-0.40.6-0.60.5-0.6-0.30.5-0.50.7-0.5-0.60.70.5-0.5-0.5
Sum of active levers in priming session hrs 5-63.63.35.12.3-2.3-2.1-2.0-2.02.0-1.7-1.81.7-1.71.8-1.9-1.91.7-1.71.5-1.7-1.61.51.7-1.7-1.6
Progressive ratio0.10.11.0-0.40.40.60.30.3-0.3-0.11.0-0.5-0.1-0.1-0.30.20.40.20.0-0.1-0.2-0.00.1-0.1-0.3
Food seeking constrained by brief footshock0.10.10.50.2-0.2-0.10.10.1-0.10.10.4-0.70.6-0.10.00.0-0.10.2-0.5-0.20.2-0.10.2-0.2-0.3
Seeking ratio, punishment vs. effort0.40.61.61.0-1.0-1.2-0.9-0.90.9-0.6-1.30.9-0.40.7-0.4-0.80.1-0.70.4-0.6-0.20.50.5-0.5-0.4
Retroperitoneal fat weight0.31.23.1-1.81.81.41.31.3-1.30.91.1-0.90.8-1.01.21.1-0.71.0-0.80.90.8-0.7-0.80.80.8
Reaction time number correct0.81.62.0-1.31.31.31.21.2-1.20.81.2-1.21.4-1.21.11.3-0.91.3-1.21.41.2-1.4-1.41.41.4
Reaction time mean minus median1.02.43.71.7-1.7-1.5-1.7-1.71.7-1.6-1.41.9-1.81.7-1.5-1.61.5-1.61.7-1.3-1.51.31.2-1.2-1.1
Reaction time mean minus median AUC1.43.55.41.8-1.8-1.8-2.0-1.91.9-1.8-1.82.3-2.12.0-1.9-1.91.8-1.92.1-1.6-1.91.81.6-1.6-1.5
Reaction time num false alarms0.91.21.81.4-1.4-1.3-1.1-1.11.1-1.1-1.20.6-0.70.8-0.8-1.11.2-1.00.8-1.2-1.21.01.2-1.2-1.3
Reaction time num false alarms AUC0.91.42.21.4-1.4-1.5-1.2-1.21.2-1.2-1.20.7-0.80.9-0.9-1.21.3-1.10.9-1.2-1.31.11.2-1.2-1.3
Reaction time trials correct on left0.81.62.0-1.31.31.31.21.2-1.20.81.2-1.21.4-1.21.11.3-0.91.3-1.21.41.2-1.4-1.41.41.4
Reaction time trials on left0.81.51.9-1.21.21.31.21.2-1.20.81.2-1.21.3-1.21.01.2-0.91.3-1.21.31.1-1.4-1.41.41.3
Reaction time mean0.81.33.41.1-1.1-1.1-1.3-1.21.2-0.9-1.31.8-1.51.3-1.1-1.10.9-1.21.4-0.8-0.81.10.8-0.8-0.6
Reaction time mean AUC1.01.63.91.2-1.2-1.2-1.4-1.31.3-1.0-1.42.0-1.61.5-1.2-1.21.0-1.41.5-0.9-0.91.20.9-0.9-0.7
Median of all reaction times0.50.72.20.7-0.7-0.8-0.9-0.90.9-0.6-1.11.5-1.11.0-0.8-0.80.5-0.91.1-0.6-0.40.80.6-0.6-0.4
Reaction time omissions1.31.82.51.5-1.5-1.4-1.4-1.41.4-1.5-1.31.3-1.31.4-1.3-1.41.3-1.31.3-1.3-1.61.21.3-1.3-1.3
Reaction time false alarm rate1.62.23.11.7-1.7-1.8-1.5-1.51.5-1.4-1.51.0-1.21.2-1.2-1.51.5-1.41.2-1.6-1.61.51.6-1.6-1.7
Reaction time premature initiation rate0.20.30.60.7-0.7-0.5-0.5-0.50.5-0.7-0.30.1-0.30.3-0.3-0.50.8-0.40.3-0.5-0.70.30.5-0.5-0.5
Reaction time premature initiations0.00.10.20.2-0.20.10.00.0-0.0-0.30.2-0.40.4-0.20.20.10.30.2-0.20.2-0.0-0.4-0.20.20.1
Std. dev. reaction times1.22.24.21.6-1.6-1.5-1.6-1.61.6-1.4-1.62.0-1.71.6-1.4-1.51.3-1.51.7-1.1-1.21.31.1-1.1-0.9
Reaction time trials completed0.81.51.9-1.21.21.31.21.2-1.20.81.2-1.21.3-1.21.01.2-0.91.3-1.21.31.1-1.4-1.41.41.3
Reaction time trials AUC0.81.51.9-1.21.21.31.21.2-1.20.81.2-1.21.4-1.21.01.3-0.91.3-1.21.31.2-1.4-1.41.41.3
Run reversals in cocaine runway, females0.00.00.20.2-0.2-0.4-0.2-0.10.1-0.3-0.40.00.1-0.10.2-0.0-0.1-0.0-0.10.10.4-0.1-0.10.10.1
Run reversals in cocaine runway, males0.80.81.8-1.31.31.31.11.1-1.11.11.4-0.90.6-0.80.60.9-0.10.8-0.60.7-0.1-0.5-0.60.60.6
Latency to leave start box in cocaine runway4.85.58.4-2.52.52.72.32.3-2.32.32.4-1.41.8-2.02.02.4-2.72.2-1.82.62.9-2.3-2.52.52.7
Latency to leave start box in cocaine runway, F7.68.710.4-2.92.93.22.92.9-3.02.83.1-2.42.7-2.72.73.0-3.13.0-2.73.13.1-3.0-3.13.13.2
Latency to leave start box in cocaine runway, M0.20.20.7-0.40.40.40.10.1-0.10.4-0.00.8-0.50.2-0.30.1-0.6-0.10.40.20.80.2-0.10.20.4
Std. dev. time between licks in bursts0.91.21.9-1.01.01.11.11.1-1.11.01.3-1.41.3-1.01.01.1-0.81.2-1.21.00.7-1.2-1.01.00.9
Total sessions with >9 infusions0.10.10.20.2-0.20.10.00.1-0.10.10.2-0.10.2-0.10.20.2-0.10.3-0.20.4-0.1-0.4-0.40.40.5
Short access day 1 total inactive lever presses0.30.30.70.7-0.7-0.6-0.7-0.70.7-0.8-0.50.5-0.50.6-0.6-0.60.4-0.50.5-0.6-0.40.40.5-0.5-0.6
Short access day 10 total inactive lever presses0.61.42.6-1.61.61.31.31.3-1.31.11.2-1.21.0-1.21.11.2-1.11.1-1.01.01.1-1.0-1.01.01.0
Short access day 1 total infusions0.10.10.50.3-0.30.30.10.1-0.10.20.3-0.40.4-0.40.40.3-0.30.4-0.40.40.3-0.7-0.50.50.5
Short access day 10 total infusions0.00.00.1-0.20.20.10.10.1-0.10.20.10.2-0.10.10.00.1-0.00.10.10.3-0.1-0.1-0.30.30.4
Short access total infusions0.20.30.6-0.20.20.50.40.4-0.40.50.5-0.50.6-0.50.60.5-0.50.6-0.60.70.4-0.8-0.70.70.8
Short access day 1 locomotion0.30.40.7-0.70.70.60.60.6-0.60.70.6-0.40.5-0.60.50.7-0.50.6-0.50.80.6-0.7-0.80.80.8
Short access day 10 total locomotion0.00.00.1-0.20.20.00.10.1-0.10.30.10.0-0.00.00.10.10.20.10.00.2-0.30.0-0.10.10.2
Short access total locomotion0.20.20.4-0.40.40.40.40.4-0.40.50.4-0.30.4-0.40.40.5-0.20.5-0.40.60.0-0.5-0.60.60.7
One hour access (0.3 mA shock)0.70.81.10.7-0.7-0.9-0.8-0.80.8-0.8-0.91.0-1.01.0-1.0-0.90.6-0.90.9-1.0-0.81.01.0-1.0-0.9
Compulsive drug intake2.42.94.42.0-2.0-2.1-1.8-1.81.8-1.4-1.81.7-1.71.6-1.4-1.81.0-1.71.4-1.8-1.11.61.8-1.8-1.7
One hour access (shock baseline)0.40.61.3-1.11.11.00.91.0-0.90.80.8-0.70.7-0.70.60.8-0.50.7-0.50.70.4-0.5-0.70.70.7
Social response proportion2.32.63.11.8-1.8-1.5-1.7-1.71.7-1.7-1.81.6-1.51.6-1.7-1.71.3-1.61.5-1.6-1.21.51.6-1.6-1.6
Social responses0.10.10.30.1-0.10.00.0-0.00.0-0.3-0.0-0.40.2-0.20.1-0.1-0.3-0.0-0.2-0.4-0.20.20.4-0.4-0.5
Social time0.20.21.2-0.40.40.30.50.4-0.40.30.5-1.10.5-0.50.50.10.10.2-0.4-0.4-0.40.20.5-0.5-0.8
Soleus weight1.75.15.8-2.42.42.02.32.3-2.32.32.1-2.02.2-2.22.22.3-2.12.3-2.22.42.4-2.3-2.42.42.4
Bone: stiffness0.00.10.4-0.70.70.30.10.2-0.2-0.00.00.4-0.20.1-0.20.20.1-0.00.40.20.00.1-0.20.20.3
Tibialis anterior weight0.00.10.30.4-0.4-0.5-0.2-0.30.3-0.3-0.3-0.20.00.1-0.1-0.3-0.4-0.2-0.2-0.50.10.20.5-0.5-0.6
Time to tail flick, vehicle, before self-admin3.03.24.01.7-1.7-1.9-1.8-1.81.8-1.5-1.91.9-2.01.8-1.9-1.81.7-1.81.8-1.7-1.61.81.7-1.7-1.6
Time to tail flick, vehicle, after self-admin0.91.12.3-1.51.51.41.11.1-1.11.00.9-0.80.9-1.00.91.1-1.01.0-0.81.01.1-0.9-1.01.01.0
Time to tail flick, test, before self-admin0.80.81.3-0.90.90.80.80.8-0.80.80.6-0.70.8-0.90.80.9-0.90.9-0.81.01.1-1.0-1.11.11.1
Time to tail flick, test, after self-admin1.11.21.9-1.01.00.81.01.0-1.00.90.9-0.81.0-0.90.71.1-1.01.1-1.01.31.4-1.3-1.41.41.4
Delta time to tail flick, vehicle, before/after SA5.55.36.6-2.52.52.62.42.4-2.42.12.3-2.42.5-2.42.42.3-2.32.3-2.22.12.2-2.1-2.12.01.9
Delta time to tail flick, test, before/after SA0.30.30.50.7-0.7-0.6-0.6-0.60.6-0.6-0.40.4-0.40.6-0.6-0.60.5-0.50.5-0.6-0.30.40.5-0.5-0.6
Tibia length0.72.03.2-1.61.61.51.41.4-1.41.01.4-1.11.4-1.21.11.5-1.11.4-1.21.71.2-1.5-1.71.71.8
Ambulatory time before self-admin0.91.32.20.7-0.7-0.9-0.9-0.91.0-0.8-1.21.0-1.21.0-1.1-1.11.2-1.21.2-1.4-1.11.51.5-1.5-1.5
Ambulatory time after self-admin0.10.10.3-0.50.50.10.20.2-0.20.1-0.1-0.10.2-0.20.10.0-0.3-0.0-0.0-0.20.50.30.2-0.2-0.3
Bone: tissue strength1.21.22.2-1.31.31.11.01.1-1.10.91.2-0.70.9-0.90.91.2-0.61.1-0.81.40.8-1.2-1.41.41.5
Total heroin consumption0.80.91.81.2-1.2-1.1-0.9-1.01.0-0.7-0.90.5-0.80.9-0.7-1.10.5-0.90.5-1.3-0.71.01.3-1.3-1.3
Bone: trabecular number0.10.20.5-0.70.70.60.50.5-0.50.40.4-0.30.3-0.30.20.3-0.40.3-0.20.10.5-0.0-0.10.10.1
Bone: trabecular spacing0.00.10.30.0-0.00.10.10.1-0.10.10.1-0.50.2-0.20.2-0.10.2-0.0-0.2-0.3-0.30.20.3-0.4-0.5
Bone: trabecular thickness4.85.98.4-2.32.32.52.32.3-2.32.02.3-1.92.3-2.42.32.5-2.42.5-2.22.82.5-2.7-2.82.82.9
Bone: trabecular tissue density0.00.10.30.2-0.2-0.0-0.1-0.10.1-0.3-0.10.10.0-0.10.10.10.30.10.00.3-0.6-0.3-0.40.40.4
Water consumed over 24 hours0.10.10.20.4-0.4-0.3-0.3-0.20.2-0.5-0.10.2-0.20.3-0.3-0.20.4-0.20.3-0.2-0.30.20.2-0.2-0.2
Number of responses in last shaping day1.11.21.9-1.21.21.01.11.2-1.21.10.9-0.81.0-1.01.01.2-0.91.1-0.91.31.0-1.1-1.31.31.4