Hub : Genes

Phf21b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Phf21b 0.06 0.05 7.0e-03 0.03 0.01 0.04 0.03 1.0e-02 8.3e-02 5.5e-03 1.2e-02
2 NAcc gene expression Phf21b 0.03 0.02 1.7e-06 0.03 0.03 0.02 0.02 8.1e-05 1.3e-05 4.8e-04 3.0e-04
3 Brain intron excision ratio chr7_117862590_117862752 0.03 0.02 3.2e-03 0 0 0.01 0 1.4e-01 1.1e-01 1.6e-02 1.9e-01
4 Brain intron excision ratio chr7_117812997_117862752 0.03 0.02 1.0e-03 0.02 0.01 0.01 0 3.3e-03 8.0e-02 2.2e-02 2.2e-01
5 IC mRNA stability Phf21b 0.12 0.11 1.2e-03 0.05 0.04 0.03 0.05 3.8e-03 5.9e-03 2.8e-02 5.4e-03
6 Liver gene expression Phf21b 0.03 0.02 8.8e-04 0.01 0 -0 0 1.9e-02 9.9e-02 3.9e-01 2.0e-01
7 Brain mRNA stability Phf21b 0.04 0.03 1.0e-04 0.06 0.02 0.05 0.05 1.4e-06 3.9e-03 3.3e-05 1.3e-05
8 NAcc mRNA stability Phf21b 0.02 0.02 4.5e-05 0.02 0.02 0.02 0.02 2.9e-04 1.2e-04 2.3e-04 1.8e-04
9 PL mRNA stability Phf21b 0.04 0.04 1.6e-04 0.04 0.03 0.04 -0 1.1e-05 5.4e-04 7.3e-05 5.4e-01
10 Brain isoform ratio NM_001130680.1 0.02 0.02 7.7e-03 0.03 0.01 0.01 0.02 8.6e-04 2.9e-02 1.4e-02 2.6e-03
11 Brain alternative polyA NM_001130680.1 0.45 0 7.5e-03 0.01 0 0.02 0.02 4.1e-02 1.9e-01 6.3e-03 3.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.81.32.0-1.11.21.1-1.4-1.4-1.2-1.4-1.2-0.91.00.7
Area under the delay curve1.61.92.8-1.11.41.6-1.5-1.6-1.2-1.4-1.1-1.21.31.7
BMI with tail2.17.112.43.5-2.8-2.52.93.02.43.12.82.4-2.40.4
BMI without tail0.30.92.71.6-1.1-1.10.80.90.90.90.90.8-0.70.5
Body weight1.56.59.93.1-2.8-2.62.82.92.42.82.72.2-2.1-0.5
Weight adjusted by age0.60.91.21.1-1.1-1.10.90.90.61.00.90.8-1.1-0.7
Bone surface0.20.40.6-0.50.60.6-0.7-0.7-0.7-0.8-0.6-0.60.60.6
Bone volume0.30.50.9-0.60.70.6-0.9-1.0-0.8-0.9-0.7-0.50.60.2
Breakpoint value in progressive ratio session0.40.51.01.0-0.7-0.70.70.80.60.30.60.7-0.7-0.0
Number of licking bursts0.60.91.4-1.01.10.7-1.0-1.0-1.1-1.1-1.2-0.90.80.1
Context. condit. distance diff. score3.44.15.11.8-2.0-2.02.02.01.91.82.02.2-2.3-2.1
Locomotion velocity, session 11.31.42.30.8-1.3-1.30.90.81.50.61.21.3-1.3-1.5
Locomotion distance, session 10.30.30.8-0.70.50.5-0.8-0.9-0.3-0.4-0.4-0.50.3-0.7
Locomotion velocity, session 23.84.47.42.7-2.3-2.62.11.92.31.92.01.9-1.9-1.3
Locomotion distance, session 20.10.10.7-0.10.00.3-0.0-0.10.10.30.1-0.00.20.9
Locomotion velocity, session 32.73.17.62.0-1.6-1.91.51.51.51.81.31.6-1.5-2.8
Locomotion distance, session 30.20.21.20.30.2-0.2-0.1-0.1-0.30.2-0.5-0.40.4-1.1
Stereotopy head waving bouts, day 32.42.84.11.6-1.8-1.71.71.61.71.31.81.9-2.0-0.9
Stereotopy head waving duration, day 34.45.27.12.3-2.5-2.52.22.22.31.92.42.5-2.7-1.5
Locomotion velocity, session 71.01.11.51.1-0.9-1.11.01.01.01.20.91.0-0.8-1.2
Locomotion distance, session 70.00.00.1-0.10.10.1-0.1-0.1-0.10.1-0.1-0.10.3-0.3
Stereotopy head waving bouts, day 74.04.56.62.3-2.2-2.62.01.92.21.71.82.1-2.2-2.3
Stereotopy head waving duration, day 72.02.44.21.8-1.6-2.01.41.41.61.01.31.5-1.6-1.6
Locomotion velocity, session 89.611.513.13.4-3.6-3.53.53.43.53.43.53.6-3.5-2.1
Locomotion distance, session 82.33.33.91.8-1.8-1.81.91.81.81.81.72.0-1.8-1.8
Degree of sensitization distance0.70.71.50.3-0.9-0.40.80.81.00.61.21.1-0.90.5
Degree of sensitization stereotypy2.12.33.81.9-1.6-1.91.41.41.61.21.21.4-1.5-1.5
Conditioned locomotion0.20.20.6-0.40.50.5-0.2-0.1-0.6-0.3-0.4-0.70.80.2
Cocaine response after cond. corrected0.20.30.8-0.20.5-0.0-0.8-0.7-0.4-0.9-0.7-0.00.1-0.3
Cocaine response after cond. not corrected0.40.51.3-0.30.7-0.0-1.0-0.9-0.6-1.1-1.0-0.30.4-0.7
Cocaine response before conditioning0.40.40.9-0.60.60.6-0.6-0.6-0.6-0.6-0.6-1.00.9-0.2
Saline control response0.30.42.2-0.20.4-0.1-0.6-0.5-0.4-0.8-0.6-0.20.1-1.5
Bone: connectivity density0.30.51.1-0.60.70.6-0.9-0.7-0.7-1.1-0.7-0.50.60.5
Bone: cortical apparent density1.01.32.5-1.61.21.4-1.1-1.0-1.3-1.2-1.0-1.01.00.6
Bone: cortical area0.30.50.91.0-0.8-0.81.00.80.60.80.70.6-0.5-0.1
Bone: cortical porosity0.00.10.30.3-0.0-0.2-0.2-0.20.1-0.10.00.00.10.6
Bone: cortical porosity0.20.20.40.6-0.5-0.60.10.20.50.30.40.4-0.30.3
Bone: cortical thickness0.20.41.2-1.10.60.9-0.5-0.5-0.6-0.6-0.3-0.30.60.7
Bone: cortical thickness0.10.10.7-0.2-0.20.20.30.30.10.40.50.3-0.30.8
Bone: cortical tissue density0.70.92.0-1.41.01.2-0.9-0.8-1.1-1.0-0.8-0.80.80.5
Condit. Reinf. active minus inactive responses1.41.52.3-1.51.21.4-1.2-1.3-1.0-1.2-1.0-1.01.21.3
Condit. Reinf. active-inactive response ratio1.21.32.1-1.41.21.3-1.2-1.3-1.0-1.3-1.0-0.71.00.8
Condit. Reinf. active responses1.51.82.1-1.41.41.4-1.3-1.3-1.2-1.4-1.3-1.41.51.1
Condit. Reinf. inactive responses0.20.30.7-0.40.60.5-0.3-0.3-0.5-0.4-0.7-0.80.7-0.0
Incentive salience index mean1.21.52.2-1.51.31.4-1.2-1.3-1.1-1.0-1.1-1.11.30.8
Condit. Reinf. lever presses0.30.40.5-0.70.70.7-0.7-0.7-0.5-0.2-0.6-0.60.7-0.3
Condit. Reinf. active minus inactive responses0.20.30.90.3-0.40.20.70.60.21.00.60.2-0.10.9
Condit. Reinf. active-inactive response ratio0.00.00.20.00.00.30.1-0.0-0.10.30.10.2-0.20.4
Condit. Reinf. active responses1.31.83.71.2-1.4-0.71.71.61.21.91.61.0-0.90.5
Condit. Reinf. inactive responses1.72.23.51.2-1.7-1.11.81.81.51.91.91.2-1.00.1
Condit. Reinf. lever presses1.11.62.81.2-1.3-1.11.71.51.31.71.31.0-1.00.2
Condit. Reinf. lever reinforcers received0.81.02.60.9-1.0-0.31.41.20.91.61.20.6-0.50.8
Conditioned reinforcement - actives0.00.10.20.10.20.4-0.1-0.0-0.2-0.2-0.1-0.20.3-0.4
Conditioned reinforcement - inactives0.30.51.71.3-0.4-0.20.40.50.50.30.50.7-0.9-1.1
Conditioned locomotion0.91.22.41.5-0.9-1.40.60.71.10.60.61.1-1.2-1.4
Patch foraging indifference point 0 sec0.30.61.5-1.20.60.5-0.6-0.6-0.9-1.2-0.7-0.70.50.3
Patch foraging indifference point AUC0.10.20.5-0.70.40.7-0.2-0.2-0.4-0.3-0.2-0.40.30.2
Delay disc. indifference point, 0s delay0.10.20.60.7-0.4-0.70.10.10.5-0.20.30.3-0.30.1
Delay disc. indifference point, 16s delay2.52.74.3-2.01.51.6-1.9-2.0-1.3-2.1-1.3-1.31.41.4
Delay disc. indifference point, 2s delay0.60.71.30.10.91.0-1.0-0.9-0.8-0.8-0.7-0.60.91.1
Delay disc. indifference point, 24s delay0.20.31.7-0.10.30.70.0-0.1-0.3-0.3-0.1-0.40.61.3
Delay disc. indifference point, 4s delay0.80.81.7-0.70.81.0-1.2-1.3-0.4-1.3-0.5-0.30.31.2
Delay disc. indifference point, 8s delay1.72.04.3-1.11.31.6-1.2-1.2-1.5-1.0-1.1-1.51.62.1
Indifference point function ln k0.71.32.21.5-1.1-1.41.01.10.91.00.80.8-0.8-1.5
Indifference point function log k0.71.32.21.5-1.1-1.41.01.10.91.00.80.8-0.8-1.5
Patch foraging total patch changes 0 sec0.40.81.8-1.30.80.6-0.8-0.8-1.0-1.3-0.9-0.80.60.2
Patch foraging total patch changes 12 sec0.00.10.3-0.5-0.20.10.10.20.10.00.40.2-0.30.1
Patch foraging total patch changes 18 sec0.91.42.6-1.61.21.2-1.3-1.4-1.2-1.3-1.1-1.00.70.2
Patch foraging total patch changes 24 sec0.10.10.70.2-0.1-0.50.10.1-0.2-0.2-0.20.1-0.0-0.8
Patch foraging total patch changes 6 sec0.60.92.8-1.70.91.1-0.8-0.8-0.9-1.1-0.8-0.80.60.8
Patch foraging time to switch 0 sec0.10.10.30.6-0.3-0.5-0.1-0.10.40.30.30.2-0.20.4
Patch foraging water rate 0 sec0.20.31.00.4-0.5-0.51.01.00.30.40.40.6-0.5-0.3
Patch foraging water rate 12 sec0.20.52.10.9-0.3-1.10.10.10.5-0.5-0.30.6-0.3-1.5
Patch foraging water rate 18 sec0.10.10.3-0.10.20.20.20.2-0.60.1-0.3-0.20.50.0
Patch foraging water rate 24 sec1.21.62.61.5-1.3-1.61.31.31.40.91.01.5-1.3-0.8
Patch foraging water rate 6 sec0.30.40.7-0.50.60.4-0.5-0.5-0.8-0.4-0.8-0.60.9-0.7
Seeking ratio, delayed vs. immediate footshock1.41.73.0-1.01.41.3-0.9-0.9-1.7-1.1-1.5-1.51.41.4
Distance traveled before self-admin0.40.50.9-1.00.80.8-0.8-0.9-0.7-0.5-0.6-0.70.7-0.3
Distance traveled after self-admin0.00.00.2-0.10.1-0.0-0.2-0.10.00.1-0.20.2-0.3-0.5
Extensor digitorum longus weight0.41.73.11.8-1.3-1.61.41.51.21.41.01.2-1.1-0.4
Bone: elastic displacement0.91.02.50.9-0.9-1.30.90.81.00.40.61.2-1.0-1.6
Bone: elastic work4.66.08.32.9-2.5-2.82.42.32.52.22.22.7-2.5-1.6
Bone: endosteal estimation3.37.112.33.5-2.8-3.22.92.72.52.72.32.3-2.4-1.6
Bone: endosteal perimeter2.24.810.73.3-2.2-2.82.32.11.92.31.61.7-1.7-1.4
Epididymis fat weight0.62.03.61.6-1.5-1.11.31.51.51.91.71.2-0.80.8
Delta time in closed arm before/after self-admin0.30.30.6-0.60.50.8-0.7-0.70.1-0.4-0.1-0.30.00.6
Delta time in open arm before/after self-admin2.02.09.51.4-1.0-1.80.80.70.90.50.51.2-1.5-3.1
Diff in mean of infusions in LGA sessions0.10.10.3-0.30.00.60.10.2-0.20.20.3-0.30.10.6
Delay discount exponential model param1.61.82.81.0-1.3-1.61.51.51.21.31.11.1-1.3-1.7
Extinction: sum of active levers before priming1.01.11.80.6-1.0-0.80.91.01.30.81.11.4-1.20.9
Active lever presses in extinction session 60.70.70.90.9-0.8-0.60.91.00.81.00.90.8-0.50.8
Bone: final force0.40.71.30.9-0.9-0.50.80.70.81.01.20.8-0.70.7
Bone: final moment0.71.12.11.0-1.2-0.81.10.91.11.11.41.1-0.90.7
Food consumed during 24 hour testing period1.42.03.10.9-1.5-1.11.61.61.51.51.81.3-1.4-0.9
Glucose1.62.53.7-1.91.71.9-1.7-1.7-1.6-1.4-1.3-1.41.51.2
Heart weight2.94.55.92.2-2.4-2.12.22.12.41.72.42.3-2.4-0.5
Delay discount hyperbolic model param1.51.72.40.9-1.3-1.51.51.61.11.31.01.0-1.2-1.6
Intermittent access intake day 1-15 change0.20.51.3-0.30.60.6-0.7-0.7-0.9-0.3-0.8-1.10.90.2
Intermittent access intake escalation0.30.61.3-0.40.70.6-0.8-0.7-1.0-0.3-0.9-1.11.00.0
Intermittent access intake escalation 21.61.83.2-1.11.31.4-1.3-1.4-1.7-0.7-1.3-1.81.50.9
Intermitt. access day 1 inactive lever presses0.10.50.90.5-0.7-0.50.40.40.70.80.91.0-0.9-0.5
Intermitt. access day 15 inactive lever presses0.10.20.60.2-0.4-0.10.20.10.60.50.70.7-0.80.0
Intermitt. access escalation Index0.30.50.9-0.40.80.6-0.8-0.8-0.6-1.0-0.9-0.40.60.3
Intermittent access day 1 total infusions0.71.22.40.9-1.0-1.01.31.40.91.00.90.8-0.9-1.5
Intermittent access day 15 total infusions0.10.21.90.40.0-0.20.10.2-0.20.1-0.3-0.40.2-1.4
Intermittent access terminal intake (last 3 days)0.20.21.30.7-0.2-0.30.40.4-0.10.40.1-0.20.1-1.1
Intermittent access total infusions0.40.51.81.0-0.6-0.70.80.80.30.70.40.2-0.3-1.4
Intermittent access day 1 locomotion0.10.10.70.3-0.0-0.30.10.10.10.0-0.10.1-0.2-0.8
Intermittent access day 15 total locomotion0.81.53.11.6-1.1-1.31.31.31.01.20.70.8-0.8-1.8
Intermittent access total locomotion1.72.03.61.9-1.4-1.71.51.51.21.51.11.0-1.0-1.6
Intermittent access standard deviation0.10.31.01.0-0.6-0.30.40.50.10.90.70.1-0.3-0.2
Left kidney weight15.973.984.69.2-9.2-8.98.88.89.18.78.88.7-8.6-4.7
Right kidney weight17.177.890.69.0-9.5-8.99.09.19.48.99.49.1-9.1-4.2
Cocaine induced anxiety1.11.62.51.4-1.5-1.01.51.51.01.31.61.1-0.90.5
Post-drug Anxiety0.20.21.6-0.0-0.10.20.1-0.0-0.1-0.00.30.00.21.3
Baseline Anxiety2.32.74.1-1.91.81.4-2.0-2.0-1.2-1.9-1.8-1.41.40.3
Tail length0.41.72.8-1.31.30.9-1.5-1.4-1.2-1.7-1.5-1.21.4-0.6
Length with tail0.10.51.30.7-0.8-0.80.80.90.70.50.70.5-0.3-1.1
Length without tail1.23.95.51.5-2.1-1.52.32.42.22.22.32.0-1.90.0
Times rat made contact with spout0.50.61.30.3-0.8-0.50.70.80.70.60.90.8-0.8-1.1
Lifetime Intake0.70.92.21.1-0.8-0.91.01.00.61.00.70.5-0.6-1.5
Liver weight, left0.71.22.31.3-0.9-0.81.11.11.11.50.91.1-0.8-1.3
Liver weight, right0.40.72.80.9-0.5-0.40.80.80.71.20.50.4-0.2-1.7
Locomotor activity1.11.72.21.5-1.3-1.41.31.31.21.41.21.4-1.3-1.1
Locomotor testing distance0.20.40.8-0.50.60.5-0.6-0.7-0.9-0.7-0.6-0.50.70.2
Locomotor testing rearing0.10.31.30.6-0.3-0.60.20.10.20.10.30.5-0.5-1.1
Locomotion in novel chamber0.50.61.6-0.00.7-0.2-0.8-0.8-0.7-1.0-1.3-0.40.6-1.1
Locomotion in novel chamber post-restriction0.40.71.6-0.10.80.8-0.2-0.2-1.00.1-0.8-1.31.21.2
Fecal boli incidents, locomotor time 10.50.81.70.4-0.9-0.61.31.30.61.00.80.9-0.8-0.5
Change in fecal boli incidents, locomotor task0.10.10.7-0.3-0.0-0.3-0.1-0.1-0.0-0.3-0.2-0.00.1-0.8
Time >=10cm from walls, locomotor time 10.40.40.80.3-0.7-0.50.80.80.20.90.80.4-0.40.5
Bouts of movement, locomotor time 10.20.21.50.3-0.20.20.40.40.00.50.4-0.10.21.2
Total resting periods, locomotor time 10.30.32.80.1-0.00.40.00.0-0.00.30.3-0.20.21.7
Rest time, locomotor task time 11.01.21.71.2-1.2-1.01.21.21.20.91.21.3-1.20.3
Distance moved, locomotor task time 10.10.10.3-0.20.30.4-0.1-0.1-0.50.1-0.3-0.60.60.1
Vertical activity count, locomotor time 10.30.71.1-0.70.81.0-0.9-0.9-1.0-0.6-0.7-1.01.00.7
Time >=10cm from walls, locomotor time 20.10.20.6-0.40.30.2-0.4-0.4-0.8-0.6-0.4-0.30.50.4
Bouts of movement, locomotor time 20.40.64.7-0.80.30.8-0.2-0.2-0.30.0-0.1-0.60.62.2
Total resting periods, locomotor time 20.40.75.6-0.90.30.9-0.1-0.1-0.20.00.0-0.50.62.4
Rest time, locomotor task time 20.10.10.3-0.20.40.3-0.5-0.5-0.1-0.6-0.4-0.00.0-0.2
Distance moved, locomotor task time 20.70.91.31.0-1.0-1.11.11.10.81.00.90.6-0.5-0.9
Vertical activity count, locomotor time 20.50.71.21.1-1.0-1.10.80.80.60.80.80.6-0.7-0.8
Light reinforcement 10.71.64.41.5-1.1-1.61.21.10.90.60.61.3-1.3-2.1
Light reinforcement 21.62.44.02.0-1.6-2.01.61.61.51.31.21.6-1.4-0.9
Bone: marrow area3.37.312.33.5-2.8-3.22.92.72.52.72.42.3-2.4-1.6
Bone: maximum diameter4.27.911.93.5-3.0-3.23.23.02.73.02.62.5-2.5-1.2
Bone: maximum force1.01.72.61.4-1.5-1.11.41.21.41.41.61.3-1.20.5
Bone: maximum moment1.42.43.71.6-1.8-1.41.71.51.71.61.91.6-1.50.4
Mean time between licks in bursts1.53.84.6-1.92.11.9-2.1-2.1-2.0-1.9-2.1-2.12.10.7
Mean num. licks in bursts1.72.64.01.3-1.8-1.21.61.81.71.62.01.6-1.6-1.2
Cd content in liver0.10.10.50.5-0.2-0.30.40.3-0.10.20.1-0.1-0.3-0.7
Co content in liver0.10.10.90.10.0-0.3-0.1-0.1-0.1-0.3-0.10.2-0.5-0.9
Cu content in liver4.04.86.6-1.72.31.8-2.1-2.2-2.3-2.5-2.6-2.22.41.7
Fe content in liver0.20.20.60.4-0.5-0.50.50.40.30.30.40.7-0.80.2
K content in liver0.40.40.70.5-0.6-0.70.50.60.60.60.50.8-0.7-0.8
Mg content in liver0.00.00.00.1-0.1-0.0-0.1-0.10.10.10.10.1-0.10.0
Mn content in liver1.11.23.51.1-0.9-1.20.70.71.00.90.71.2-1.1-1.9
Na content in liver1.51.62.2-1.41.31.4-1.0-1.1-1.2-0.6-1.2-1.41.51.4
Rb content in liver0.10.10.7-0.30.10.3-0.3-0.2-0.2-0.7-0.1-0.1-0.10.8
Se content in liver0.20.20.7-0.50.40.2-0.4-0.3-0.5-0.8-0.5-0.50.4-0.1
Sr content in liver0.60.50.8-0.80.80.8-0.7-0.7-0.7-0.6-0.7-0.80.90.5
Zn content in liver0.60.73.40.8-0.6-0.80.40.50.70.60.50.8-0.7-1.8
Bone: minimum diameter0.61.13.41.8-0.9-1.51.00.80.61.30.50.6-0.5-1.2
Time in familiar zone, hab. session 10.80.81.11.0-0.8-1.00.70.80.91.10.70.9-0.9-0.7
Time in novel zone, hab. session 10.40.40.8-0.50.60.6-0.5-0.6-0.8-0.9-0.7-0.60.60.4
Total zone transitions, hab. session 11.42.02.4-1.51.51.6-1.5-1.5-1.5-1.3-1.4-1.41.50.6
Total locomotion distance, hab. session 10.20.31.70.8-0.3-0.60.40.40.30.40.10.2-0.2-1.3
Locomotion velocity, hab. session 10.30.41.60.9-0.5-0.70.50.50.50.50.30.3-0.4-1.3
Time in familiar zone, hab. session 20.20.21.1-0.10.1-0.3-0.4-0.40.1-0.8-0.30.3-0.2-1.1
Time in novel zone, hab. session 20.10.10.3-0.30.30.5-0.1-0.1-0.5-0.1-0.2-0.50.40.6
Total zone transitions, hab. session 20.50.61.30.6-0.8-0.60.60.60.91.10.81.0-0.9-0.2
Total locomotion distance, hab. session 20.50.71.01.0-0.8-0.90.80.70.91.00.60.8-0.8-0.7
Locomotion velocity, hab. session 20.40.50.80.8-0.7-0.70.70.60.80.90.60.7-0.7-0.5
Novel to familiar place preference ratio0.20.20.60.5-0.4-0.40.30.40.30.50.30.3-0.4-0.8
Novelty place preference0.40.41.50.7-0.6-0.70.50.60.50.60.40.4-0.5-1.2
Time in novel zone, NPP test0.50.51.90.7-0.6-0.70.50.70.50.60.40.5-0.6-1.4
Total zone transitions, NPP test0.10.10.2-0.50.30.4-0.2-0.2-0.2-0.1-0.3-0.10.1-0.4
Total locomotion distance, NPP test0.50.71.61.0-0.6-1.00.80.70.70.70.40.8-0.9-1.3
Locomotion velocity, NPP test0.20.30.80.7-0.3-0.70.50.40.50.40.10.3-0.4-0.9
Intraocular pressure0.10.10.50.50.10.0-0.2-0.10.00.7-0.0-0.30.3-0.4
Delta distance traveled before/after self-admin1.21.32.11.4-1.0-1.40.80.91.10.80.71.3-1.5-1.3
Delta ambulatory time before/after self-admin0.81.02.01.2-0.8-1.10.70.81.10.70.61.3-1.4-0.9
Parametrial fat weight0.71.72.4-1.11.41.2-1.4-1.5-1.1-1.1-1.4-1.51.60.3
Pavlov. Cond. lever latency0.70.91.30.8-1.1-1.01.01.01.00.51.11.1-1.10.3
Pavlov. Cond. magazine entry latency2.73.55.0-2.12.02.2-1.8-1.9-1.9-1.3-1.8-1.91.91.4
Pavlov. Cond. change in total contacts3.33.54.7-1.81.92.2-1.7-1.8-2.0-1.3-1.7-2.12.02.1
Pavlov. Cond. index score2.12.64.0-1.91.82.0-1.6-1.6-1.7-1.0-1.5-1.71.81.0
Pavlov. Cond. latency score1.41.82.6-1.41.51.6-1.3-1.3-1.4-0.7-1.3-1.51.50.5
Pavlov. Cond. lever contacts1.72.02.8-1.31.61.6-1.4-1.5-1.6-0.7-1.6-1.71.70.2
Pavlov. Cond. magazine entry number3.64.56.72.4-2.3-2.61.91.92.21.51.92.3-2.3-1.7
Pavlov. Cond. intertrial magazine entries0.30.41.3-0.70.50.5-0.6-0.6-0.5-1.1-0.6-0.50.40.4
Pavlov. Cond. lever-magazine prob. diff.2.53.14.4-2.01.92.1-1.8-1.8-1.8-1.2-1.7-1.91.91.1
Pavlov. Cond. response bias3.34.15.6-2.22.22.4-1.9-2.0-2.1-1.4-1.9-2.22.21.5
Pavlov. Cond. lever latency0.60.92.0-0.90.90.7-1.1-1.1-0.8-1.4-0.9-0.80.9-0.0
Pavlov. Cond. magazine entry latency0.30.43.7-0.40.20.6-0.1-0.2-0.1-0.1-0.1-0.40.31.9
Pavlov. Cond. change in total contacts0.50.81.50.6-0.8-0.30.90.80.81.21.00.9-1.01.1
Pavlov. Cond. index score0.20.31.20.2-0.30.10.50.40.30.80.40.2-0.21.1
Pavlov. Cond. latency score0.20.31.70.3-0.30.00.60.50.40.90.40.1-0.21.3
Pavlov. Cond. lever contacts0.40.61.40.7-0.7-0.51.00.90.71.20.80.7-0.80.3
Pavlov. Cond. magazine entry number0.20.20.9-0.10.2-0.1-0.5-0.4-0.1-0.6-0.3-0.20.3-1.0
Pavlov. Cond. intertrial magazine entries0.30.51.00.5-0.8-0.40.80.80.70.81.00.6-0.60.5
Pavlov. Cond. lever-magazine prob. diff.0.20.20.80.4-0.3-0.10.60.50.40.80.40.3-0.30.9
Pavlov. Cond. response bias0.20.20.80.1-0.30.10.50.40.30.70.50.4-0.40.9
Time in closed arm before self-admin3.24.15.3-2.22.01.9-1.9-1.7-2.3-2.3-2.1-2.22.21.2
Time in closed arm after self-admin2.62.84.1-1.71.81.6-2.0-1.8-1.8-1.8-1.7-1.91.30.6
Time in open arm before self-admin0.20.20.60.8-0.2-0.00.50.30.10.80.3-0.40.50.2
Time in open arm after self-admin3.23.55.62.3-1.9-2.41.81.71.81.61.51.8-1.8-2.0
Bone: periosteal estimation2.24.78.12.8-2.3-2.62.52.22.02.31.91.8-1.8-1.1
Bone: periosteal perimeter1.83.06.42.5-1.7-2.21.91.81.51.81.31.5-1.3-1.2
Bone: post-yield work0.20.32.1-0.70.10.7-0.3-0.30.0-0.10.4-0.1-0.11.4
Progressive ratio test 1 active lever presses0.10.10.40.3-0.00.00.20.30.2-0.3-0.0-0.00.1-0.6
Progressive ratio test 1 breakpoint0.10.10.20.00.20.2-0.00.10.0-0.5-0.2-0.30.3-0.5
Progressive ratio test 1 inactive lever presses0.40.61.40.8-0.6-0.80.50.40.90.50.60.9-0.9-1.2
Progressive ratio test 2 active lever presses1.31.52.61.1-1.3-1.01.51.61.21.01.31.2-1.3-0.8
Progressive ratio test 2 breakpoint1.21.32.21.1-1.2-0.91.41.51.11.01.21.1-1.2-0.9
Progressive ratio test 2 inactive lever presses0.20.40.80.8-0.5-0.20.80.70.20.70.50.3-0.5-0.9
Incentive Sensitization - Responses1.72.33.61.2-1.6-1.31.71.71.61.21.71.8-1.9-0.8
Incentive Sensitization - Breakpoint2.12.74.01.4-1.8-1.51.81.81.71.41.81.9-2.0-0.8
Sum of active levers in priming session hrs 5-60.50.40.90.5-0.7-1.00.70.70.80.50.60.7-0.40.0
Progressive ratio0.50.82.7-1.70.81.2-0.4-0.5-0.9-0.2-0.5-0.60.91.0
Food seeking constrained by brief footshock0.20.20.60.7-0.4-0.40.40.40.50.40.40.6-0.7-0.2
Seeking ratio, punishment vs. effort0.60.82.61.6-0.9-1.00.70.71.00.60.80.8-1.1-0.1
Retroperitoneal fat weight2.08.712.02.9-3.2-2.73.33.43.23.53.32.8-2.5-0.0
Reaction time number correct0.30.61.4-0.70.80.9-0.1-0.1-0.9-0.5-0.9-0.91.20.3
Reaction time mean minus median0.00.00.1-0.00.20.30.00.0-0.2-0.1-0.2-0.20.1-0.2
Reaction time mean minus median AUC0.30.71.31.0-0.8-0.71.11.10.71.00.70.6-0.6-0.6
Reaction time num false alarms0.50.71.2-0.71.00.8-0.5-0.6-1.1-0.5-1.1-0.90.9-0.6
Reaction time num false alarms AUC0.30.51.4-0.60.80.6-0.2-0.4-0.7-0.2-0.8-0.60.6-1.2
Reaction time trials correct on left0.30.61.4-0.70.80.9-0.1-0.1-0.9-0.5-0.9-0.91.20.3
Reaction time trials on left0.30.61.5-0.80.80.9-0.1-0.1-1.0-0.6-1.0-1.01.20.3
Reaction time mean0.40.72.1-0.80.80.9-0.7-0.7-0.6-0.7-0.7-0.70.71.4
Reaction time mean AUC0.40.61.8-0.80.70.9-0.6-0.6-0.5-0.5-0.6-0.70.71.3
Median of all reaction times0.71.13.5-1.11.01.1-0.9-1.0-0.7-0.9-0.8-0.80.81.9
Reaction time omissions0.40.61.1-0.90.80.9-0.7-0.7-0.4-1.1-0.7-0.50.60.7
Reaction time false alarm rate0.10.20.9-0.30.40.2-0.3-0.4-0.4-0.0-0.4-0.20.1-1.0
Reaction time premature initiation rate1.11.62.90.8-1.4-0.71.61.51.30.91.71.2-1.31.1
Reaction time premature initiations0.40.71.80.3-0.8-0.21.31.30.70.51.10.7-0.61.1
Std. dev. reaction times0.00.10.1-0.10.30.4-0.1-0.2-0.1-0.3-0.3-0.20.20.2
Reaction time trials completed0.30.61.5-0.80.80.9-0.1-0.1-1.0-0.6-1.0-1.01.20.3
Reaction time trials AUC0.20.30.9-0.50.60.70.10.1-0.7-0.3-0.7-0.71.00.3
Run reversals in cocaine runway, females2.32.33.7-1.21.60.9-1.8-1.8-1.6-1.9-1.8-1.51.6-0.0
Run reversals in cocaine runway, males0.80.81.91.0-0.8-0.91.11.00.61.20.60.4-0.5-1.4
Latency to leave start box in cocaine runway0.91.11.51.0-1.1-1.20.70.81.10.81.11.2-1.2-1.0
Latency to leave start box in cocaine runway, F0.50.51.10.6-0.8-0.70.50.50.80.50.90.8-1.0-0.7
Latency to leave start box in cocaine runway, M0.70.61.30.9-0.9-1.10.50.60.80.50.71.0-0.6-0.8
Std. dev. time between licks in bursts0.40.54.0-0.50.30.50.0-0.0-0.4-0.2-0.3-0.70.72.0
Total sessions with >9 infusions2.53.03.71.5-1.8-1.71.91.91.61.91.71.6-1.7-1.6
Short access day 1 total inactive lever presses2.43.25.61.4-1.8-1.61.81.81.81.81.82.2-2.4-1.0
Short access day 10 total inactive lever presses0.92.23.91.7-1.5-1.61.11.01.71.31.42.0-1.7-1.0
Short access day 1 total infusions0.60.81.80.3-0.8-0.80.80.90.81.00.80.9-1.0-1.4
Short access day 10 total infusions0.20.20.50.4-0.4-0.20.60.70.20.70.40.00.0-0.4
Short access total infusions1.21.52.31.0-1.3-1.11.41.51.11.51.21.1-1.1-1.1
Short access day 1 locomotion0.30.30.70.5-0.5-0.70.20.30.70.40.40.6-0.7-0.8
Short access day 10 total locomotion0.20.40.7-0.80.70.4-0.7-0.7-0.4-0.2-0.6-0.80.6-0.8
Short access total locomotion0.00.10.5-0.20.0-0.2-0.2-0.10.20.1-0.1-0.1-0.0-0.7
One hour access (0.3 mA shock)0.50.61.31.1-0.6-0.61.11.20.10.80.4-0.00.0-1.0
Compulsive drug intake0.40.40.9-0.5-0.50.01.00.90.40.90.80.6-0.50.4
One hour access (shock baseline)0.20.31.50.9-0.0-0.40.20.3-0.30.1-0.3-0.40.4-1.2
Social response proportion0.30.30.50.2-0.7-0.70.60.60.50.50.60.5-0.6-0.2
Social responses0.30.40.80.1-0.6-0.70.90.90.60.40.50.3-0.2-0.9
Social time2.73.68.0-2.81.92.1-1.9-1.9-1.6-2.2-1.6-1.81.80.8
Soleus weight0.41.12.10.9-1.0-0.51.11.11.31.41.31.0-1.00.8
Bone: stiffness0.30.54.6-0.20.20.7-0.3-0.4-0.4-0.20.1-0.40.52.1
Tibialis anterior weight0.00.10.90.10.0-0.0-0.10.00.2-0.0-0.1-0.00.11.0
Time to tail flick, vehicle, before self-admin0.20.20.8-0.0-0.6-0.40.50.50.20.30.60.4-0.4-0.9
Time to tail flick, vehicle, after self-admin0.10.10.70.8-0.0-0.10.30.3-0.4-0.1-0.1-0.20.0-0.1
Time to tail flick, test, before self-admin0.00.00.10.30.0-0.0-0.1-0.1-0.30.10.0-0.20.3-0.3
Time to tail flick, test, after self-admin0.50.61.0-0.20.80.7-1.0-0.9-0.8-0.6-0.8-0.90.70.7
Delta time to tail flick, vehicle, before/after SA1.01.02.21.5-0.9-0.61.21.20.91.20.90.7-0.70.8
Delta time to tail flick, test, before/after SA0.40.40.7-0.60.70.6-0.8-0.8-0.5-0.9-0.8-0.60.40.5
Tibia length0.10.40.70.4-0.6-0.60.60.60.60.60.50.8-0.8-0.6
Ambulatory time before self-admin0.20.31.0-0.70.50.5-0.5-0.5-0.3-0.4-0.5-0.40.3-1.0
Ambulatory time after self-admin0.30.30.9-0.40.60.3-0.7-0.7-0.3-0.9-0.7-0.2-0.0-0.7
Bone: tissue strength0.10.10.40.2-0.4-0.20.20.10.5-0.10.40.4-0.40.6
Total heroin consumption1.92.23.41.4-1.6-1.11.81.81.61.81.71.4-1.00.5
Bone: trabecular number1.52.53.6-1.31.61.4-1.9-1.9-1.7-1.9-1.7-1.41.50.3
Bone: trabecular spacing3.54.66.62.0-2.2-2.02.62.52.32.62.32.0-2.0-0.3
Bone: trabecular thickness0.30.40.7-0.50.60.4-0.7-0.8-0.7-0.8-0.6-0.40.4-0.4
Bone: trabecular tissue density0.20.30.8-0.60.50.7-0.2-0.2-0.6-0.1-0.4-0.60.50.9
Water consumed over 24 hours1.01.42.00.8-1.3-1.11.21.31.21.01.31.2-1.4-1.0
Number of responses in last shaping day0.60.71.2-1.10.91.0-0.9-0.9-0.9-0.6-0.6-0.60.60.7