Hub : Genes

Phf21b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Phf21b	0.03	0.02	4.0e-04	0.01	0.01	0	-0	8.4e-03	2.8e-02	8.1e-02	4.1e-01
2	NAcc	gene expression	Phf21b	0.03	0.02	2.3e-04	0.03	0.03	0.02	0.02	2.1e-04	3.5e-04	1.4e-03	1.4e-03
3	Brain	mRNA stability	Phf21b	0.04	0.03	9.5e-05	0.06	0	0.03	0.01	4.6e-06	1.1e-01	4.2e-04	1.5e-02
4	Brain	intron excision ratio	chr7_115982664_115982826	0.03	0.02	1.8e-03	0.03	0.01	0.03	0.03	1.7e-03	1.4e-02	1.9e-03	2.1e-03
5	Brain	intron excision ratio	chr7_115933064_115982826	0.03	0.02	4.6e-04	0.03	0.01	0.03	0.01	3.6e-04	1.8e-02	5.9e-04	1.4e-02
6	PL	mRNA stability	Phf21b	0.04	0.03	2.2e-04	0.04	0.03	0.04	0.01	8.8e-06	2.7e-04	2.0e-05	6.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.8	1.3	1.9	1.4	-1.3	1.2	-0.8	1.0	0.9
Area under the delay curve	2.1	2.2	3.6	1.4	-1.9	1.6	-1.3	1.3	1.3
BMI with tail	2.5	8.1	10.6	-3.1	3.0	-3.3	2.8	-2.4	-2.5
BMI without tail	1.7	3.6	4.6	-2.0	2.1	-2.1	1.8	-1.7	-1.7
Body weight	1.1	4.6	6.9	-2.4	2.4	-2.6	1.8	-1.7	-1.6
Weight adjusted by age	1.1	1.2	2.0	-1.3	1.0	-1.4	1.1	-0.8	-0.8
Bone surface	0.2	0.4	0.5	0.7	-0.5	0.7	-0.4	0.7	0.7
Bone volume	0.3	0.4	0.9	0.9	-0.8	0.7	-0.3	0.6	0.6
Breakpoint value in progressive ratio session	0.3	0.4	0.6	-0.4	0.7	-0.3	0.6	-0.7	-0.7
Number of licking bursts	1.0	1.1	1.4	1.1	-1.1	1.2	-0.9	0.9	1.0
Context. condit. distance diff. score	3.6	4.3	4.9	-2.0	2.1	-2.0	2.2	-2.1	-2.1
Locomotion velocity, session 1	1.4	1.5	2.7	-1.6	1.0	-0.8	1.4	-1.3	-1.2
Locomotion distance, session 1	0.2	0.2	0.5	0.4	-0.7	0.4	-0.3	0.4	0.5
Locomotion velocity, session 2	3.6	4.2	5.6	-2.4	2.0	-1.9	2.0	-2.0	-2.0
Locomotion distance, session 2	0.0	0.0	0.1	-0.0	-0.2	-0.3	-0.2	0.2	0.2
Locomotion velocity, session 3	2.2	2.5	3.0	-1.7	1.5	-1.7	1.5	-1.5	-1.6
Locomotion distance, session 3	0.1	0.1	0.2	0.2	-0.1	-0.2	-0.3	0.4	0.3
Stereotopy head waving bouts, day 3	3.0	3.6	4.2	-1.9	1.9	-1.5	2.0	-2.0	-2.0
Stereotopy head waving duration, day 3	4.6	5.5	6.4	-2.3	2.3	-1.9	2.5	-2.5	-2.5
Locomotion velocity, session 7	1.0	1.1	1.9	-1.0	1.0	-1.4	0.9	-1.0	-1.0
Locomotion distance, session 7	0.0	0.1	0.2	0.0	-0.2	-0.5	-0.1	0.1	0.1
Stereotopy head waving bouts, day 7	4.9	5.5	6.5	-2.4	2.2	-1.9	2.5	-2.6	-2.5
Stereotopy head waving duration, day 7	1.7	2.1	2.5	-1.5	1.4	-1.0	1.6	-1.6	-1.6
Locomotion velocity, session 8	10.7	12.8	14.2	-3.8	3.5	-3.6	3.5	-3.5	-3.5
Locomotion distance, session 8	2.2	3.3	3.9	-1.8	1.8	-2.0	1.9	-1.7	-1.7
Degree of sensitization distance	0.9	0.9	1.0	-1.0	0.7	-1.0	1.0	-1.0	-1.0
Degree of sensitization stereotypy	1.8	1.9	2.1	-1.5	1.3	-1.3	1.4	-1.4	-1.4
Conditioned locomotion	0.5	0.6	1.0	0.7	-0.6	0.1	-1.0	0.9	0.9
Cocaine response after cond. corrected	0.3	0.3	0.8	0.5	-0.9	0.8	-0.2	0.0	0.0
Cocaine response after cond. not corrected	0.4	0.4	1.0	0.7	-1.0	0.9	-0.2	0.1	0.1
Cocaine response before conditioning	0.2	0.3	0.3	0.6	-0.4	0.4	-0.3	0.6	0.6
Saline control response	0.3	0.4	0.8	0.8	-0.8	0.9	-0.2	0.2	0.2
Bone: connectivity density	0.4	0.7	1.3	0.9	-0.7	1.2	-0.6	0.7	0.7
Bone: cortical apparent density	0.7	0.9	1.4	0.9	-1.2	1.2	-0.8	0.8	0.7
Bone: cortical area	0.2	0.3	0.5	-0.5	0.6	-0.7	0.5	-0.4	-0.3
Bone: cortical porosity	0.0	0.0	0.0	-0.2	0.1	0.1	0.1	-0.0	-0.0
Bone: cortical porosity	0.1	0.1	0.3	-0.5	0.4	-0.2	0.4	-0.3	-0.3
Bone: cortical thickness	0.2	0.4	0.5	0.7	-0.6	0.7	-0.6	0.6	0.6
Bone: cortical thickness	0.0	0.0	0.1	0.0	0.0	-0.2	0.1	-0.1	-0.0
Bone: cortical tissue density	0.4	0.6	1.0	0.7	-1.0	1.0	-0.6	0.6	0.5
Condit. Reinf. active minus inactive responses	1.5	1.7	1.9	1.2	-1.3	1.4	-1.4	1.3	1.2
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.0	1.2	-1.3	1.4	-1.0	0.9	0.9
Condit. Reinf. active responses	1.9	2.3	2.8	1.4	-1.4	1.6	-1.7	1.5	1.5
Condit. Reinf. inactive responses	0.4	0.5	0.9	0.6	-0.4	0.4	-0.9	0.8	0.8
Incentive salience index mean	1.4	1.7	2.1	1.3	-1.3	1.1	-1.5	1.4	1.3
Condit. Reinf. lever presses	0.3	0.4	0.7	0.7	-0.7	0.3	-0.8	0.7	0.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.9	-0.5	0.4	-1.0	-0.0	-0.1	-0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.0	-0.1	-0.5	0.0	-0.2	-0.2
Condit. Reinf. active responses	1.3	1.8	3.9	-1.5	1.5	-2.0	0.8	-0.9	-0.9
Condit. Reinf. inactive responses	1.8	2.3	3.6	-1.7	1.9	-1.9	1.2	-1.1	-1.0
Condit. Reinf. lever presses	1.0	1.4	2.6	-1.2	1.4	-1.6	0.8	-0.9	-0.9
Condit. Reinf. lever reinforcers received	0.8	1.1	2.8	-1.2	1.2	-1.7	0.4	-0.6	-0.6
Conditioned reinforcement - actives	0.6	0.6	0.7	0.8	-0.6	0.8	-0.8	0.8	0.8
Conditioned reinforcement - inactives	0.0	0.1	0.1	0.0	0.2	-0.3	0.4	-0.2	-0.2
Conditioned locomotion	1.0	1.2	1.8	-0.9	0.9	-0.7	1.3	-1.3	-1.3
Patch foraging indifference point 0 sec	0.3	0.4	1.3	0.4	-0.6	1.2	-0.3	0.5	0.5
Patch foraging indifference point AUC	0.0	0.0	0.2	0.3	0.0	0.4	-0.2	-0.1	-0.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.4	-0.1	0.3	0.3	-0.5	-0.3
Delay disc. indifference point, 16s delay	3.0	3.1	4.9	1.5	-2.2	2.2	-1.4	1.5	1.4
Delay disc. indifference point, 2s delay	0.5	0.6	1.1	0.9	-1.1	0.7	-0.7	0.6	0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.1	-0.3	0.3	-0.6	0.3	0.3
Delay disc. indifference point, 4s delay	0.7	0.7	1.9	0.7	-1.3	1.4	-0.2	0.2	0.3
Delay disc. indifference point, 8s delay	1.9	2.0	2.6	1.1	-1.4	1.0	-1.6	1.6	1.6
Indifference point function ln k	0.8	1.1	1.8	-1.2	1.1	-1.3	1.0	-0.8	-0.8
Indifference point function log k	0.8	1.1	1.8	-1.2	1.1	-1.3	1.0	-0.8	-0.8
Patch foraging total patch changes 0 sec	0.4	0.7	2.0	0.6	-0.8	1.4	-0.5	0.6	0.7
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	-0.3	0.2	0.1	0.3	-0.4	-0.4
Patch foraging total patch changes 18 sec	1.1	1.4	2.6	1.6	-1.4	1.5	-0.5	0.9	0.9
Patch foraging total patch changes 24 sec	0.0	0.1	0.2	0.1	0.1	0.5	0.2	-0.1	-0.2
Patch foraging total patch changes 6 sec	0.4	0.6	1.5	0.8	-0.7	1.2	-0.5	0.5	0.5
Patch foraging time to switch 0 sec	0.0	0.1	0.2	-0.2	-0.1	-0.4	0.3	-0.1	-0.1
Patch foraging water rate 0 sec	0.2	0.3	0.7	-0.5	0.9	-0.4	0.3	-0.5	-0.5
Patch foraging water rate 12 sec	0.1	0.2	0.4	-0.2	0.3	0.4	0.5	-0.6	-0.6
Patch foraging water rate 18 sec	0.1	0.1	0.2	0.3	-0.0	-0.2	-0.4	0.4	0.3
Patch foraging water rate 24 sec	0.9	1.3	1.6	-1.1	1.3	-0.9	1.3	-1.1	-1.1
Patch foraging water rate 6 sec	0.2	0.3	0.5	0.7	-0.3	0.4	-0.5	0.6	0.6
Seeking ratio, delayed vs. immediate footshock	1.4	1.6	2.4	1.5	-0.8	1.0	-1.5	1.3	1.3
Distance traveled before self-admin	0.0	0.0	0.1	0.1	0.1	-0.3	-0.3	-0.0	0.1
Distance traveled after self-admin	0.8	0.8	1.4	-0.5	0.8	-0.9	0.9	-1.2	-1.1
Extensor digitorum longus weight	0.3	1.2	2.1	-1.1	1.2	-1.5	0.8	-1.0	-1.0
Bone: elastic displacement	1.0	1.1	1.9	-0.9	0.7	-0.5	1.3	-1.3	-1.4
Bone: elastic work	4.5	5.8	6.8	-2.3	2.2	-2.2	2.6	-2.6	-2.6
Bone: endosteal estimation	3.0	6.4	7.7	-2.6	2.6	-2.8	2.5	-2.4	-2.3
Bone: endosteal perimeter	1.7	3.6	5.5	-1.9	2.0	-2.4	1.8	-1.7	-1.6
Epididymis fat weight	0.3	0.6	1.0	-1.0	0.5	-0.5	0.9	-0.8	-0.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	0.3	-0.5	0.1	-0.0	-0.1	-0.2
Delta time in open arm before/after self-admin	0.7	0.7	1.1	-0.8	0.6	-0.5	1.0	-1.0	-1.0
Diff in mean of infusions in LGA sessions	0.9	1.0	1.8	1.0	-0.5	0.5	-0.8	1.4	1.3
Delay discount exponential model param	2.0	2.1	3.6	-1.4	1.9	-1.5	1.2	-1.2	-1.2
Extinction: sum of active levers before priming	0.2	0.2	0.5	-0.5	0.2	-0.0	-0.2	-0.7	-0.7
Active lever presses in extinction session 6	0.8	0.8	1.4	-1.0	1.1	-1.2	0.5	-0.6	-0.7
Bone: final force	0.5	0.9	1.1	-0.9	0.9	-1.1	1.0	-0.9	-0.9
Bone: final moment	0.9	1.4	1.5	-1.2	1.2	-1.2	1.2	-1.1	-1.2
Food consumed during 24 hour testing period	1.7	2.1	2.5	-1.6	1.5	-1.5	1.3	-1.4	-1.4
Glucose	2.2	3.4	4.0	1.9	-2.0	1.6	-1.9	1.8	1.8
Heart weight	0.1	0.1	0.3	0.2	-0.4	0.5	0.3	-0.2	-0.0
Delay discount hyperbolic model param	1.5	1.6	3.0	-1.3	1.7	-1.4	1.0	-1.0	-1.0
Intermittent access intake day 1-15 change	0.6	0.6	1.1	0.6	-0.7	0.4	-0.6	1.0	0.9
Intermittent access intake escalation	0.4	0.4	0.7	0.4	-0.6	0.3	-0.7	0.8	0.8
Intermittent access intake escalation 2	0.7	0.7	1.1	0.6	-0.9	0.6	-0.7	1.1	1.1
Intermitt. access day 1 inactive lever presses	2.0	2.2	3.1	-1.2	1.1	-1.3	1.7	-1.6	-1.7
Intermitt. access day 15 inactive lever presses	1.5	1.7	2.3	-1.3	1.0	-1.1	1.2	-1.5	-1.5
Intermitt. access escalation Index	0.1	0.1	0.2	-0.1	-0.1	0.3	-0.1	-0.4	-0.4
Intermittent access day 1 total infusions	0.6	0.6	1.5	-0.7	1.2	-0.9	0.6	-0.5	-0.5
Intermittent access day 15 total infusions	0.1	0.1	0.3	-0.5	0.6	-0.5	0.2	0.1	0.1
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.7	-0.7	0.8	-0.8	0.4	-0.0	-0.0
Intermittent access total infusions	0.4	0.4	0.9	-0.8	1.0	-0.9	0.3	-0.2	-0.2
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.1	0.3	-0.3	0.1	-0.1	-0.1
Intermittent access day 15 total locomotion	0.6	0.6	1.1	-0.7	1.0	-0.9	0.8	-0.6	-0.6
Intermittent access total locomotion	1.2	1.3	2.1	-1.2	1.4	-1.3	1.1	-0.9	-0.9
Intermittent access standard deviation	0.6	0.6	0.8	-0.9	0.8	-0.9	0.9	-0.7	-0.7
Left kidney weight	15.6	43.7	48.8	-7.0	6.6	-6.5	6.5	-6.5	-6.6
Right kidney weight	15.8	44.2	45.7	-6.8	6.6	-6.4	6.7	-6.7	-6.7
Cocaine induced anxiety	4.8	5.6	7.5	-2.7	2.5	-2.4	2.2	-2.2	-2.2
Post-drug Anxiety	2.4	2.7	3.7	-1.9	1.5	-1.6	1.5	-1.6	-1.6
Baseline Anxiety	4.1	4.3	5.7	2.2	-2.4	2.1	-2.0	1.8	1.8
Tail length	0.1	0.3	0.4	0.4	-0.4	0.6	-0.7	0.5	0.5
Length with tail	0.0	0.0	0.1	-0.1	0.3	-0.3	-0.2	0.0	0.1
Length without tail	0.2	0.4	0.6	-0.6	0.7	-0.8	0.5	-0.6	-0.5
Times rat made contact with spout	0.5	0.6	0.8	-0.7	0.6	-0.5	0.9	-0.9	-0.9
Lifetime Intake	0.6	0.7	1.4	-0.9	1.1	-1.2	0.5	-0.4	-0.4
Liver weight, left	0.3	0.5	1.2	-0.6	0.6	-1.1	0.5	-0.6	-0.7
Liver weight, right	0.1	0.2	0.7	-0.3	0.5	-0.8	-0.0	-0.0	-0.0
Locomotor activity	1.1	1.8	2.3	-1.1	1.4	-1.4	1.5	-1.3	-1.4
Locomotor testing distance	0.0	0.1	0.2	0.4	-0.1	0.3	0.1	0.2	0.1
Locomotor testing rearing	0.1	0.2	0.6	-0.2	0.4	-0.1	0.8	-0.5	-0.5
Locomotion in novel chamber	0.5	0.7	1.3	1.1	-0.9	1.0	-0.7	0.2	0.4
Locomotion in novel chamber post-restriction	0.4	0.5	0.9	0.7	-0.1	-0.5	-1.0	0.9	0.8
Fecal boli incidents, locomotor time 1	0.6	0.7	1.6	-0.7	1.2	-0.9	0.5	-0.6	-0.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.2	-0.3	0.4	-0.3	0.3	0.2
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	-0.6	0.9	-0.7	0.6	-0.4	-0.5
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.2	0.3	-0.4	-0.1	0.1	0.1
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.0	0.0	-0.1	-0.3	0.2	0.2
Rest time, locomotor task time 1	0.8	0.8	1.1	-1.0	1.0	-0.6	0.7	-1.0	-1.1
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.4	0.1	-0.4	0.0	0.3	0.4
Vertical activity count, locomotor time 1	0.3	0.4	0.6	0.7	-0.5	0.4	-0.3	0.8	0.8
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.4	0.0	-0.2	0.6	-0.3	0.2	0.1
Bouts of movement, locomotor time 2	0.2	0.2	0.4	0.3	-0.1	0.1	-0.6	0.6	0.6
Total resting periods, locomotor time 2	0.2	0.2	0.4	0.2	-0.0	0.1	-0.7	0.6	0.5
Rest time, locomotor task time 2	0.1	0.2	0.5	0.4	-0.5	0.7	-0.3	0.1	0.1
Distance moved, locomotor task time 2	0.9	1.1	1.7	-1.1	1.3	-1.2	0.9	-0.8	-0.8
Vertical activity count, locomotor time 2	1.2	1.3	2.1	-1.4	1.4	-1.0	1.1	-0.9	-0.9
Light reinforcement 1	0.7	1.3	2.1	-0.8	0.9	-0.5	1.4	-1.4	-1.4
Light reinforcement 2	1.5	2.0	2.5	-1.5	1.4	-1.2	1.2	-1.6	-1.6
Bone: marrow area	3.1	6.7	8.0	-2.7	2.6	-2.8	2.6	-2.5	-2.3
Bone: maximum diameter	3.7	6.7	8.6	-2.6	2.8	-2.9	2.5	-2.4	-2.3
Bone: maximum force	1.3	2.2	2.5	-1.5	1.5	-1.5	1.6	-1.4	-1.3
Bone: maximum moment	1.7	2.9	3.5	-1.9	1.7	-1.7	1.8	-1.6	-1.6
Mean time between licks in bursts	3.0	4.3	4.7	2.0	-2.0	2.0	-2.2	2.1	2.1
Mean num. licks in bursts	2.5	3.0	3.3	-1.8	1.7	-1.6	1.7	-1.7	-1.8
Cd content in liver	0.2	0.3	0.4	0.5	-0.5	0.7	-0.4	0.5	0.5
Co content in liver	0.5	0.6	1.4	-0.4	0.5	-0.4	1.2	-0.9	-0.9
Cu content in liver	5.2	6.3	7.9	2.5	-2.4	2.5	-2.8	2.5	2.4
Fe content in liver	0.1	0.2	0.4	0.4	-0.3	0.3	0.6	-0.4	-0.3
K content in liver	0.5	0.5	0.7	-0.8	0.6	-0.4	0.6	-0.8	-0.8
Mg content in liver	0.0	0.0	0.1	-0.3	0.1	0.1	0.1	-0.3	-0.3
Mn content in liver	0.9	1.1	1.4	-1.0	0.8	-1.2	1.0	-1.1	-1.1
Na content in liver	3.0	3.1	4.8	1.7	-1.6	1.3	-2.2	1.9	1.9
Rb content in liver	0.4	0.5	1.2	0.7	-0.7	1.1	-0.6	0.6	0.6
Se content in liver	0.1	0.1	0.5	0.3	-0.3	0.7	-0.4	0.3	0.2
Sr content in liver	0.5	0.4	0.6	0.7	-0.7	0.3	-0.7	0.7	0.7
Zn content in liver	1.1	1.2	1.5	1.2	-1.1	0.7	-1.2	1.2	1.1
Bone: minimum diameter	0.4	0.7	1.6	-0.8	0.9	-1.3	0.7	-0.6	-0.5
Time in familiar zone, hab. session 1	0.9	0.9	1.3	-0.8	0.8	-0.8	1.0	-1.1	-1.1
Time in novel zone, hab. session 1	0.4	0.4	0.6	0.7	-0.8	0.7	-0.5	0.6	0.7
Total zone transitions, hab. session 1	1.7	2.3	3.1	1.5	-1.8	1.2	-1.5	1.6	1.6
Total locomotion distance, hab. session 1	0.1	0.1	0.2	-0.4	0.2	-0.4	0.3	-0.4	-0.3
Locomotion velocity, hab. session 1	0.2	0.2	0.3	-0.5	0.3	-0.5	0.4	-0.5	-0.5
Time in familiar zone, hab. session 2	0.1	0.1	0.5	0.1	-0.3	0.7	0.1	-0.3	-0.3
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.3	-0.1	0.1	-0.2	0.4	0.4
Total zone transitions, hab. session 2	0.5	0.7	1.2	-0.7	0.4	-1.1	0.9	-0.7	-0.8
Total locomotion distance, hab. session 2	0.5	0.6	0.8	-0.7	0.6	-0.9	0.9	-0.8	-0.7
Locomotion velocity, hab. session 2	0.3	0.4	0.6	-0.6	0.5	-0.8	0.7	-0.7	-0.6
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.4	0.4	-0.3	0.2	-0.2	-0.1
Novelty place preference	0.2	0.2	0.4	-0.6	0.7	-0.4	0.4	-0.3	-0.3
Time in novel zone, NPP test	0.3	0.3	0.4	-0.6	0.7	-0.4	0.5	-0.4	-0.4
Total zone transitions, NPP test	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.0	0.1	0.1
Total locomotion distance, NPP test	0.4	0.6	0.9	-0.6	0.6	-0.7	0.9	-0.9	-0.9
Locomotion velocity, NPP test	0.1	0.2	0.2	-0.4	0.3	-0.4	0.4	-0.4	-0.4
Intraocular pressure	0.1	0.1	0.3	-0.2	0.0	-0.6	-0.2	0.1	0.1
Delta distance traveled before/after self-admin	1.6	1.8	3.3	-1.0	1.0	-0.8	1.8	-1.5	-1.5
Delta ambulatory time before/after self-admin	1.1	1.2	2.2	-0.7	0.7	-0.5	1.5	-1.3	-1.3
Parametrial fat weight	0.1	0.1	0.5	0.4	-0.7	0.3	-0.0	-0.0	0.0
Pavlov. Cond. lever latency	1.4	1.8	2.3	-1.4	1.5	-0.7	1.5	-1.5	-1.4
Pavlov. Cond. magazine entry latency	3.4	4.3	5.2	2.2	-2.3	1.6	-2.2	2.1	2.0
Pavlov. Cond. change in total contacts	3.5	3.7	4.4	2.0	-2.0	1.4	-2.0	2.1	2.1
Pavlov. Cond. index score	2.2	2.8	3.5	1.7	-1.9	1.1	-1.8	1.8	1.6
Pavlov. Cond. latency score	1.6	2.0	2.5	1.5	-1.6	0.8	-1.6	1.5	1.4
Pavlov. Cond. lever contacts	1.8	2.2	2.7	1.6	-1.6	0.6	-1.6	1.6	1.5
Pavlov. Cond. magazine entry number	3.4	4.2	5.2	-2.1	2.1	-1.4	2.3	-2.2	-2.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.6	0.6	-0.5	1.3	-0.3	0.4	0.5
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.6	4.5	1.9	-2.1	1.4	-2.0	2.0	1.8
Pavlov. Cond. response bias	3.8	4.7	5.5	2.3	-2.3	1.5	-2.3	2.3	2.1
Pavlov. Cond. lever latency	0.4	0.5	1.1	0.6	-0.9	1.0	-0.6	0.5	0.5
Pavlov. Cond. magazine entry latency	0.2	0.3	0.5	0.4	-0.3	0.3	-0.5	0.7	0.7
Pavlov. Cond. change in total contacts	0.4	0.5	1.0	-0.6	0.8	-1.0	0.6	-0.5	-0.5
Pavlov. Cond. index score	0.1	0.1	0.3	-0.1	0.3	-0.6	-0.1	0.2	0.2
Pavlov. Cond. latency score	0.1	0.1	0.4	-0.1	0.4	-0.6	-0.1	0.2	0.2
Pavlov. Cond. lever contacts	0.6	0.8	1.7	-0.8	1.0	-1.3	0.7	-0.7	-0.7
Pavlov. Cond. magazine entry number	0.0	0.0	0.2	0.0	-0.3	0.5	-0.0	-0.0	-0.0
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.0	-0.8	0.9	-1.0	0.7	-0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	-0.1	0.3	-0.6	-0.0	0.1	0.1
Pavlov. Cond. response bias	0.2	0.3	0.8	-0.5	0.6	-0.9	0.4	-0.4	-0.4
Time in closed arm before self-admin	1.7	1.9	2.7	1.2	-1.2	1.7	-1.4	1.5	1.4
Time in closed arm after self-admin	0.8	0.8	1.5	1.1	-1.2	1.0	-0.6	0.7	0.6
Time in open arm before self-admin	0.2	0.2	0.4	0.0	0.4	-0.5	-0.4	0.6	0.6
Time in open arm after self-admin	1.6	1.8	2.6	-1.6	1.6	-1.3	1.1	-1.2	-1.1
Bone: periosteal estimation	1.9	3.9	5.1	-2.0	2.1	-2.3	2.0	-1.8	-1.7
Bone: periosteal perimeter	1.2	2.0	3.0	-1.4	1.6	-1.7	1.3	-1.3	-1.2
Bone: post-yield work	0.0	0.0	0.1	0.1	-0.3	0.3	0.2	-0.0	0.0
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.1	0.3	-0.1	-0.3	0.3	0.3
Progressive ratio test 1 breakpoint	0.2	0.2	0.4	0.4	0.1	-0.0	-0.6	0.6	0.6
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.5	-0.3	0.2	-0.4	0.6	-0.7	-0.7
Progressive ratio test 2 active lever presses	0.7	0.7	1.5	-0.9	1.2	-0.7	0.7	-0.7	-0.7
Progressive ratio test 2 breakpoint	0.8	0.9	1.9	-1.0	1.4	-0.9	0.7	-0.8	-0.8
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.4	-1.0	1.2	-1.1	0.7	-0.7	-0.7
Incentive Sensitization - Responses	2.8	2.8	3.2	-1.7	1.7	-1.3	1.7	-1.8	-1.8
Incentive Sensitization - Breakpoint	3.3	3.4	3.9	-1.9	1.8	-1.5	1.9	-2.0	-2.0
Sum of active levers in priming session hrs 5-6	0.6	0.5	0.9	-0.9	1.0	-0.9	0.4	-0.6	-0.6
Progressive ratio	0.3	0.3	0.4	0.6	-0.5	0.3	-0.6	0.7	0.6
Food seeking constrained by brief footshock	0.3	0.4	0.9	-0.2	0.5	-0.5	0.9	-0.6	-0.8
Seeking ratio, punishment vs. effort	0.5	0.6	0.9	-0.7	0.7	-0.6	1.0	-0.9	-0.9
Retroperitoneal fat weight	1.3	4.2	5.2	-2.3	2.1	-2.3	1.9	-1.9	-1.8
Reaction time number correct	0.5	0.7	1.3	0.9	-0.3	0.5	-1.1	1.0	1.0
Reaction time mean minus median	0.0	0.0	0.1	0.2	0.3	0.0	-0.2	0.0	0.1
Reaction time mean minus median AUC	0.5	0.7	1.7	-0.8	1.3	-1.0	0.4	-0.5	-0.5
Reaction time num false alarms	0.8	1.1	2.4	1.6	-0.9	0.7	-0.9	1.0	1.0
Reaction time num false alarms AUC	0.5	0.7	2.1	1.4	-0.8	0.5	-0.6	0.7	0.7
Reaction time trials correct on left	0.5	0.7	1.3	0.9	-0.3	0.5	-1.1	1.0	1.0
Reaction time trials on left	0.6	0.8	1.4	0.9	-0.3	0.6	-1.2	1.0	1.0
Reaction time mean	0.5	0.7	0.9	0.9	-0.6	0.7	-0.9	0.8	0.9
Reaction time mean AUC	0.5	0.6	1.0	0.8	-0.5	0.5	-1.0	0.9	1.0
Median of all reaction times	0.9	1.2	1.4	1.2	-1.1	1.0	-1.1	1.0	1.1
Reaction time omissions	0.8	1.1	1.5	0.9	-0.9	1.2	-1.2	1.0	1.0
Reaction time false alarm rate	0.2	0.2	0.8	0.9	-0.7	0.3	-0.0	0.2	0.3
Reaction time premature initiation rate	1.2	1.6	2.7	-1.7	1.5	-0.7	0.9	-1.2	-1.3
Reaction time premature initiations	0.4	0.6	1.5	-1.1	1.2	-0.4	0.4	-0.6	-0.7
Std. dev. reaction times	0.0	0.1	0.1	0.3	0.1	0.2	-0.3	0.2	0.3
Reaction time trials completed	0.6	0.8	1.4	0.9	-0.3	0.6	-1.2	1.0	1.0
Reaction time trials AUC	0.3	0.4	0.8	0.7	-0.0	0.3	-0.9	0.8	0.8
Run reversals in cocaine runway, females	2.7	2.6	3.6	1.7	-1.7	1.9	-1.3	1.5	1.5
Run reversals in cocaine runway, males	0.3	0.3	0.9	-0.4	0.7	-0.9	0.5	-0.3	-0.3
Latency to leave start box in cocaine runway	1.3	1.4	1.8	-1.2	1.0	-0.8	1.3	-1.3	-1.4
Latency to leave start box in cocaine runway, F	0.2	0.3	0.5	-0.3	0.4	-0.1	0.7	-0.6	-0.7
Latency to leave start box in cocaine runway, M	1.8	1.7	2.6	-1.6	1.2	-1.2	1.2	-1.4	-1.2
Std. dev. time between licks in bursts	0.3	0.4	0.7	0.1	0.1	0.4	-0.9	0.8	0.8
Total sessions with >9 infusions	0.1	0.1	0.4	-0.2	0.6	-0.7	0.1	0.2	0.2
Short access day 1 total inactive lever presses	3.0	3.3	4.1	-1.4	1.6	-1.9	2.0	-2.0	-2.0
Short access day 10 total inactive lever presses	3.0	3.3	5.1	-1.5	1.1	-1.4	2.2	-2.2	-2.2
Short access day 1 total infusions	0.7	0.8	1.6	-0.4	0.8	-1.3	1.0	-0.7	-0.7
Short access day 10 total infusions	0.3	0.3	0.5	0.1	0.4	-0.5	-0.6	0.7	0.7
Short access total infusions	0.9	1.0	2.9	-0.9	1.3	-1.7	0.6	-0.5	-0.5
Short access day 1 locomotion	0.1	0.1	0.3	0.5	-0.2	0.1	0.2	0.0	0.1
Short access day 10 total locomotion	0.6	0.7	1.0	1.0	-0.7	0.4	-0.7	1.0	1.0
Short access total locomotion	0.1	0.1	0.1	0.3	0.0	-0.3	-0.1	0.3	0.4
One hour access (0.3 mA shock)	0.2	0.2	0.8	-0.4	0.9	-0.5	0.0	0.2	0.2
Compulsive drug intake	0.0	0.0	0.1	-0.3	0.3	-0.1	-0.0	-0.2	-0.2
One hour access (shock baseline)	0.1	0.1	0.2	0.0	0.2	-0.1	-0.3	0.5	0.5
Social response proportion	0.3	0.3	0.5	-0.5	0.4	-0.3	0.7	-0.6	-0.6
Social responses	0.2	0.3	0.6	-0.8	0.8	-0.3	0.5	-0.3	-0.4
Social time	3.0	4.0	4.8	2.1	-2.1	2.2	-1.8	1.9	1.9
Soleus weight	0.2	0.6	1.7	-0.6	0.8	-1.3	0.6	-0.5	-0.5
Bone: stiffness	0.1	0.1	0.3	0.2	-0.3	0.3	-0.3	0.5	0.5
Tibialis anterior weight	0.0	0.0	0.0	-0.0	-0.0	-0.1	-0.1	-0.0	-0.0
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	-0.5	0.5	-0.1	0.5	-0.3	-0.3
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.0	0.2	0.1	-0.4	0.2	0.2
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.2	0.1	-0.2	0.1	0.0	-0.0
Time to tail flick, test, after self-admin	1.6	1.7	2.4	1.5	-1.4	1.3	-0.9	1.2	1.2
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	-0.3	0.5	-0.7	0.3	-0.4	-0.4
Delta time to tail flick, test, before/after SA	1.2	1.1	1.7	1.1	-1.2	1.3	-0.7	0.8	0.9
Tibia length	0.2	0.5	0.8	-0.6	0.5	-0.6	0.8	-0.9	-0.9
Ambulatory time before self-admin	0.1	0.1	0.2	-0.0	0.3	-0.5	0.1	-0.3	-0.3
Ambulatory time after self-admin	0.2	0.2	0.5	-0.1	0.3	-0.0	0.5	-0.7	-0.6
Bone: tissue strength	0.1	0.1	0.2	-0.5	0.2	0.1	0.4	-0.5	-0.4
Total heroin consumption	1.0	1.2	2.9	-1.1	1.7	-1.4	0.7	-0.7	-0.6
Bone: trabecular number	1.3	2.1	2.7	1.7	-1.5	1.6	-1.2	1.3	1.3
Bone: trabecular spacing	3.5	4.5	6.3	-2.2	2.3	-2.5	1.9	-1.9	-1.9
Bone: trabecular thickness	0.3	0.3	0.6	0.7	-0.8	0.7	-0.3	0.4	0.4
Bone: trabecular tissue density	0.2	0.3	0.5	0.4	-0.6	0.3	-0.6	0.6	0.7
Water consumed over 24 hours	1.8	2.2	2.7	-1.6	1.6	-1.1	1.6	-1.5	-1.5
Number of responses in last shaping day	0.9	1.0	2.1	1.5	-1.0	0.6	-0.6	1.0	1.0