Hub : Genes

Phb1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Phb1	0.04	0.03	7.0e-05	0.03	0.02	0.03	0.01	4.9e-04	1.1e-03	7.8e-04	1.4e-02
2	PL	gene expression	Phb1	0.03	0.02	2.8e-03	0.01	0.01	0.01	0	1.1e-02	1.4e-02	3.1e-02	7.8e-02
3	Liver	gene expression	Phb1	0.01	0.01	8.9e-03	0	0.01	0	0	1.5e-01	2.0e-02	8.2e-02	1.4e-01
4	Brain	gene expression	Phb1	0.07	0.05	2.1e-06	0.07	0.06	0.06	0.07	2.6e-07	1.0e-06	2.7e-06	7.5e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.8	1.3	2.5	1.6	1.1	-1.0	0.8
Area under the delay curve	0.0	0.0	0.2	-0.1	-0.1	-0.0	0.4
BMI with tail	12.6	40.9	66.7	8.2	7.1	-5.9	3.5
BMI without tail	0.5	1.1	2.9	1.7	1.0	-0.6	0.0
Body weight	0.8	3.3	5.2	2.3	1.6	-1.7	1.6
Weight adjusted by age	0.1	0.1	0.2	-0.5	-0.4	0.3	0.3
Bone surface	0.3	0.5	0.9	0.8	0.4	-0.6	1.0
Bone volume	0.9	1.5	2.1	1.4	0.8	-1.2	1.5
Breakpoint value in progressive ratio session	2.5	2.8	4.3	-2.1	-1.5	1.6	-1.4
Number of licking bursts	1.2	1.4	1.9	-0.8	-1.1	1.3	-1.4
Context. condit. distance diff. score	0.7	0.8	1.1	1.1	0.9	-1.0	0.5
Locomotion velocity, session 1	0.2	0.2	0.5	-0.1	-0.2	0.4	-0.7
Locomotion distance, session 1	4.1	5.2	6.0	-2.5	-2.4	2.4	-1.9
Locomotion velocity, session 2	0.7	0.8	1.6	-1.3	-1.0	0.7	0.0
Locomotion distance, session 2	5.9	8.2	9.1	-3.0	-2.8	2.9	-2.7
Locomotion velocity, session 3	1.0	1.1	2.0	0.5	1.0	-1.1	1.4
Locomotion distance, session 3	0.9	1.0	1.6	-1.2	-0.9	1.0	-0.8
Stereotopy head waving bouts, day 3	3.9	4.6	5.4	2.1	2.3	-2.3	1.8
Stereotopy head waving duration, day 3	3.1	3.7	4.3	1.9	1.9	-2.1	1.9
Locomotion velocity, session 7	0.6	0.7	1.2	-0.9	-1.1	0.8	-0.4
Locomotion distance, session 7	5.1	6.4	8.6	-2.5	-2.9	2.6	-2.0
Stereotopy head waving bouts, day 7	0.3	0.4	0.6	0.5	0.8	-0.7	0.4
Stereotopy head waving duration, day 7	0.3	0.4	0.6	0.3	0.8	-0.8	0.6
Locomotion velocity, session 8	0.5	0.6	1.2	0.3	1.1	-1.0	0.5
Locomotion distance, session 8	0.7	1.0	1.4	-1.0	-0.8	1.0	-1.2
Degree of sensitization distance	0.2	0.2	0.4	-0.2	-0.7	0.4	-0.2
Degree of sensitization stereotypy	0.4	0.4	0.7	-0.6	-0.4	0.6	-0.9
Conditioned locomotion	1.4	1.7	2.4	1.5	1.3	-1.3	1.0
Cocaine response after cond. corrected	4.2	4.8	6.5	2.5	2.6	-2.1	1.2
Cocaine response after cond. not corrected	2.5	2.8	4.1	1.9	2.0	-1.6	0.9
Cocaine response before conditioning	2.0	2.4	3.3	-1.8	-1.6	1.6	-1.0
Saline control response	0.4	0.6	1.7	0.7	-0.0	0.4	-1.3
Bone: connectivity density	0.1	0.2	0.4	0.6	0.4	-0.3	0.4
Bone: cortical apparent density	3.6	4.8	6.8	-2.6	-2.6	2.0	-1.3
Bone: cortical area	0.4	0.6	0.9	1.0	0.6	-0.8	0.8
Bone: cortical porosity	0.4	0.4	0.6	0.8	0.7	-0.5	0.6
Bone: cortical porosity	0.2	0.2	0.5	0.7	0.5	-0.4	0.4
Bone: cortical thickness	0.3	0.5	0.7	0.6	0.5	-0.8	0.8
Bone: cortical thickness	0.2	0.3	0.7	-0.9	-0.5	0.4	-0.1
Bone: cortical tissue density	4.1	5.3	7.5	-2.7	-2.7	2.1	-1.4
Condit. Reinf. active minus inactive responses	0.9	1.0	1.4	-0.9	-1.1	1.2	-0.8
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	0.4	0.2	-0.0	-0.1
Condit. Reinf. active responses	1.1	1.3	1.8	-1.0	-1.2	1.3	-1.0
Condit. Reinf. inactive responses	1.3	1.5	1.7	-1.2	-1.2	1.3	-1.3
Incentive salience index mean	1.9	2.3	3.0	-1.4	-1.5	1.7	-1.5
Condit. Reinf. lever presses	2.9	3.9	4.7	-1.8	-1.8	2.1	-2.2
Condit. Reinf. active minus inactive responses	0.5	0.6	1.4	-0.1	-0.7	0.8	-1.2
Condit. Reinf. active-inactive response ratio	1.2	1.3	3.0	-0.2	-0.7	1.2	-1.7
Condit. Reinf. active responses	0.2	0.3	0.4	-0.1	-0.6	0.5	-0.6
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.1	0.1	-0.4	0.5
Condit. Reinf. lever presses	0.2	0.3	0.6	-0.8	-0.7	0.4	0.0
Condit. Reinf. lever reinforcers received	0.2	0.3	0.4	-0.1	-0.7	0.6	-0.6
Conditioned reinforcement - actives	0.4	0.4	0.7	0.0	-0.7	0.7	-0.9
Conditioned reinforcement - inactives	0.2	0.2	0.3	0.3	-0.5	0.4	-0.4
Conditioned locomotion	0.2	0.2	0.4	0.6	0.2	0.1	-0.7
Patch foraging indifference point 0 sec	1.3	2.0	2.4	1.1	1.6	-1.5	1.5
Patch foraging indifference point AUC	0.0	0.0	0.0	-0.1	-0.2	0.0	-0.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.4	-0.1	-0.1	0.4
Delay disc. indifference point, 16s delay	1.2	1.2	1.5	1.0	1.1	-1.2	1.1
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.2	-0.5	0.2	0.3
Delay disc. indifference point, 24s delay	0.7	0.7	0.9	-0.9	-0.9	0.9	-0.5
Delay disc. indifference point, 4s delay	0.6	0.7	1.1	-1.0	-1.0	0.6	0.4
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.3	-0.3	0.2	0.2
Indifference point function ln k	0.0	0.1	0.2	-0.4	-0.1	0.2	-0.1
Indifference point function log k	0.0	0.1	0.2	-0.4	-0.1	0.2	-0.1
Patch foraging total patch changes 0 sec	1.5	2.4	2.7	1.3	1.6	-1.6	1.6
Patch foraging total patch changes 12 sec	0.0	0.1	0.2	0.5	-0.1	-0.1	-0.0
Patch foraging total patch changes 18 sec	2.4	3.1	3.5	1.7	1.9	-1.8	1.6
Patch foraging total patch changes 24 sec	0.9	1.1	1.4	1.0	1.2	-1.1	0.8
Patch foraging total patch changes 6 sec	0.9	1.4	1.5	1.2	1.2	-1.2	1.0
Patch foraging time to switch 0 sec	0.1	0.2	0.3	-0.3	-0.4	0.5	-0.5
Patch foraging water rate 0 sec	1.7	2.8	3.1	1.8	1.7	-1.7	1.5
Patch foraging water rate 12 sec	0.7	1.1	1.5	0.8	1.2	-1.1	1.0
Patch foraging water rate 18 sec	0.0	0.0	0.1	0.2	-0.0	-0.0	-0.1
Patch foraging water rate 24 sec	1.2	1.7	2.2	1.5	1.4	-1.3	1.0
Patch foraging water rate 6 sec	0.1	0.1	0.4	0.1	0.4	-0.0	-0.6
Seeking ratio, delayed vs. immediate footshock	1.7	1.9	2.3	1.5	1.3	-1.3	1.5
Distance traveled before self-admin	4.0	4.3	7.6	-1.4	-1.7	2.1	-2.8
Distance traveled after self-admin	0.2	0.2	0.3	0.5	0.6	0.1	-0.5
Extensor digitorum longus weight	0.9	3.5	4.1	1.7	1.8	-1.9	2.0
Bone: elastic displacement	0.0	0.0	0.1	0.3	0.0	0.0	-0.2
Bone: elastic work	0.0	0.0	0.1	0.3	-0.2	0.0	-0.1
Bone: endosteal estimation	0.0	0.0	0.0	0.2	-0.1	0.1	0.1
Bone: endosteal perimeter	0.1	0.2	0.3	0.5	0.4	-0.3	0.3
Epididymis fat weight	0.1	0.3	1.2	1.1	0.2	-0.1	-0.1
Delta time in closed arm before/after self-admin	0.3	0.3	1.0	0.3	0.1	-0.4	1.0
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.3	0.1	-0.0	0.1
Diff in mean of infusions in LGA sessions	1.8	2.0	2.5	-1.3	-1.4	1.6	-1.4
Delay discount exponential model param	0.1	0.1	0.1	0.3	0.3	-0.1	-0.3
Extinction: sum of active levers before priming	0.8	0.8	1.4	-0.8	-1.2	0.9	-0.4
Active lever presses in extinction session 6	0.1	0.1	0.4	-0.0	0.6	-0.2	0.1
Bone: final force	0.1	0.2	0.6	0.8	0.1	-0.1	-0.0
Bone: final moment	0.1	0.2	0.7	0.9	0.3	-0.3	-0.0
Food consumed during 24 hour testing period	1.7	2.1	2.5	-1.6	-1.5	1.5	-1.1
Glucose	1.3	1.9	3.0	1.2	1.1	-1.4	1.7
Heart weight	1.0	1.4	2.8	1.7	0.7	-1.0	1.2
Delay discount hyperbolic model param	0.1	0.1	0.1	0.3	0.4	-0.2	-0.4
Intermittent access intake day 1-15 change	0.6	0.6	1.1	0.7	1.0	-0.7	0.5
Intermittent access intake escalation	0.3	0.3	0.6	0.4	0.8	-0.5	0.5
Intermittent access intake escalation 2	0.3	0.3	0.8	0.6	0.9	-0.4	0.2
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.4	0.2	-0.2	0.3	-0.7
Intermitt. access day 15 inactive lever presses	1.9	2.0	2.5	1.3	1.3	-1.5	1.6
Intermitt. access escalation Index	0.2	0.2	0.5	-0.7	-0.2	0.5	-0.3
Intermittent access day 1 total infusions	0.6	0.7	1.9	-0.5	-1.4	0.9	-0.3
Intermittent access day 15 total infusions	0.4	0.5	0.9	-0.5	-0.9	0.8	-0.5
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.5	-0.1	-0.7	0.5	-0.4
Intermittent access total infusions	0.2	0.3	0.8	0.0	-0.9	0.5	-0.2
Intermittent access day 1 locomotion	1.8	1.9	3.2	-1.2	-1.8	1.5	-0.9
Intermittent access day 15 total locomotion	0.4	0.5	0.9	-0.4	-1.0	0.7	-0.4
Intermittent access total locomotion	0.6	0.7	1.5	-0.4	-1.2	0.9	-0.7
Intermittent access standard deviation	0.6	0.7	1.2	1.1	0.8	-0.7	0.6
Left kidney weight	0.1	0.4	1.3	0.1	-0.2	-0.3	1.2
Right kidney weight	0.8	2.1	4.0	1.1	1.0	-1.5	2.0
Cocaine induced anxiety	0.3	0.4	1.2	0.1	-0.2	0.4	-1.1
Post-drug Anxiety	2.0	2.2	3.8	-0.8	-1.4	1.5	-1.9
Baseline Anxiety	0.0	0.0	0.1	0.0	-0.0	-0.2	0.4
Tail length	12.3	37.1	51.8	-7.2	-7.0	5.9	-3.5
Length with tail	5.3	19.3	31.8	-5.6	-5.4	3.9	-1.2
Length without tail	0.2	0.5	1.6	0.0	-0.1	-0.7	1.3
Times rat made contact with spout	0.6	0.6	0.9	-0.7	-1.0	0.9	-0.6
Lifetime Intake	0.3	0.3	0.7	-0.3	-0.8	0.5	-0.3
Liver weight, left	0.6	1.0	1.4	-1.1	-1.2	1.0	-0.7
Liver weight, right	0.3	0.6	1.3	-0.5	-1.2	0.4	0.7
Locomotor activity	0.2	0.3	0.6	0.7	0.5	-0.0	-0.8
Locomotor testing distance	0.4	0.6	1.3	0.9	0.7	-0.1	-1.1
Locomotor testing rearing	0.3	0.4	1.4	0.4	0.2	0.3	-1.2
Locomotion in novel chamber	0.4	0.5	0.8	-0.1	-0.7	0.9	-0.8
Locomotion in novel chamber post-restriction	0.8	0.9	2.6	1.6	0.7	-0.7	0.4
Fecal boli incidents, locomotor time 1	3.0	3.3	4.8	1.4	2.2	-1.9	1.6
Change in fecal boli incidents, locomotor task	1.6	1.5	2.1	-1.1	-1.4	1.5	-0.8
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.3	-0.0	-0.2	0.8	-1.2
Bouts of movement, locomotor time 1	0.5	0.5	0.8	0.6	0.5	-0.9	0.9
Total resting periods, locomotor time 1	0.9	1.0	1.4	0.9	0.8	-1.2	1.1
Rest time, locomotor task time 1	0.2	0.2	0.3	0.2	0.5	-0.5	0.6
Distance moved, locomotor task time 1	3.1	3.3	4.2	-1.5	-1.8	1.9	-2.1
Vertical activity count, locomotor time 1	1.0	1.1	2.2	-0.5	-0.9	1.0	-1.5
Time >=10cm from walls, locomotor time 2	0.5	0.5	0.6	-0.5	-0.7	0.8	-0.8
Bouts of movement, locomotor time 2	0.1	0.1	0.1	0.4	-0.2	0.1	-0.2
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.5	-0.2	0.1	-0.4
Rest time, locomotor task time 2	0.2	0.3	0.8	-0.9	-0.1	0.5	-0.2
Distance moved, locomotor task time 2	0.2	0.2	0.4	-0.4	-0.7	0.2	0.3
Vertical activity count, locomotor time 2	0.1	0.1	0.5	-0.1	-0.7	0.2	-0.1
Light reinforcement 1	0.1	0.2	0.7	0.1	0.1	0.2	-0.8
Light reinforcement 2	0.6	0.8	1.1	-0.9	-0.6	0.9	-1.1
Bone: marrow area	0.0	0.0	0.1	0.1	-0.2	0.2	-0.0
Bone: maximum diameter	0.1	0.2	0.4	0.6	0.5	-0.4	0.3
Bone: maximum force	0.5	0.8	1.4	1.2	0.7	-0.9	0.8
Bone: maximum moment	0.6	1.1	1.5	1.2	0.9	-1.0	0.9
Mean time between licks in bursts	1.2	1.6	2.0	1.4	1.1	-1.3	1.3
Mean num. licks in bursts	0.3	0.3	0.9	0.1	0.2	-0.5	1.0
Cd content in liver	1.2	1.3	3.8	-0.2	-0.5	1.1	-2.0
Co content in liver	0.1	0.2	0.5	0.2	0.0	0.2	-0.7
Cu content in liver	10.1	12.2	14.7	-3.2	-3.8	3.7	-3.2
Fe content in liver	2.1	2.5	3.2	-1.4	-1.8	1.6	-1.5
K content in liver	0.6	0.6	1.8	-0.6	-1.3	0.6	0.2
Mg content in liver	2.5	2.5	5.5	-1.4	-2.4	1.6	-0.6
Mn content in liver	3.6	4.1	5.8	-2.4	-2.1	2.0	-1.5
Na content in liver	0.4	0.5	1.3	-0.5	-1.1	0.6	0.1
Rb content in liver	0.4	0.5	1.3	-0.3	-0.4	0.5	-1.1
Se content in liver	0.0	0.0	0.1	0.4	0.1	-0.1	-0.1
Sr content in liver	0.5	0.4	0.8	-0.9	-0.8	0.4	0.4
Zn content in liver	0.4	0.4	0.7	0.0	-0.8	0.8	-0.7
Bone: minimum diameter	0.1	0.2	0.5	0.4	-0.1	-0.2	0.7
Time in familiar zone, hab. session 1	0.5	0.5	1.3	-0.2	-0.5	0.6	-1.1
Time in novel zone, hab. session 1	3.2	3.1	4.5	1.2	1.8	-1.8	2.1
Total zone transitions, hab. session 1	6.4	8.9	9.7	-3.0	-3.0	3.1	-2.8
Total locomotion distance, hab. session 1	4.0	5.7	6.3	-2.3	-2.4	2.5	-2.3
Locomotion velocity, hab. session 1	5.2	7.3	8.2	-2.6	-2.9	2.9	-2.6
Time in familiar zone, hab. session 2	1.1	1.1	2.1	1.1	1.4	-1.0	0.4
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.4	-0.7	0.4	-0.1
Total zone transitions, hab. session 2	4.9	6.4	7.3	-2.5	-2.4	2.5	-2.7
Total locomotion distance, hab. session 2	1.2	1.5	1.8	-1.0	-1.3	1.3	-1.3
Locomotion velocity, hab. session 2	1.2	1.6	1.9	-1.2	-1.4	1.3	-1.2
Novel to familiar place preference ratio	0.4	0.4	0.6	-0.4	-0.7	0.8	-0.5
Novelty place preference	0.3	0.3	0.4	-0.4	-0.5	0.7	-0.4
Time in novel zone, NPP test	0.1	0.1	0.2	-0.2	-0.3	0.5	-0.4
Total zone transitions, NPP test	6.2	8.8	9.8	-3.1	-2.7	3.0	-3.1
Total locomotion distance, NPP test	2.3	3.1	3.6	-1.6	-1.8	1.8	-1.9
Locomotion velocity, NPP test	2.5	3.6	4.2	-1.8	-2.0	1.9	-1.7
Intraocular pressure	1.1	1.6	1.7	-1.3	-1.2	1.3	-1.2
Delta distance traveled before/after self-admin	3.3	3.5	4.4	1.7	1.9	-1.8	2.1
Delta ambulatory time before/after self-admin	3.5	3.8	4.9	1.9	1.9	-1.8	2.2
Parametrial fat weight	0.3	0.5	0.8	-0.4	-0.7	0.8	-0.9
Pavlov. Cond. lever latency	2.0	2.5	4.5	1.1	1.3	-1.7	2.1
Pavlov. Cond. magazine entry latency	0.4	0.5	1.4	-0.3	-0.3	0.7	-1.2
Pavlov. Cond. change in total contacts	4.6	4.9	6.7	-1.8	-2.0	2.3	-2.6
Pavlov. Cond. index score	1.6	2.0	4.0	-0.9	-1.1	1.5	-2.0
Pavlov. Cond. latency score	1.5	1.9	3.7	-0.9	-1.1	1.4	-1.9
Pavlov. Cond. lever contacts	3.3	3.9	6.0	-1.6	-1.7	2.0	-2.5
Pavlov. Cond. magazine entry number	1.0	1.2	2.3	0.6	0.9	-1.2	1.5
Pavlov. Cond. intertrial magazine entries	1.0	1.2	2.0	-0.9	-1.4	1.2	-0.7
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	3.6	-0.8	-0.9	1.4	-1.9
Pavlov. Cond. response bias	1.4	1.7	3.5	-0.8	-0.9	1.3	-1.9
Pavlov. Cond. lever latency	2.0	2.8	3.5	-1.2	-1.6	1.8	-1.9
Pavlov. Cond. magazine entry latency	0.4	0.5	0.9	-1.0	-0.5	0.1	0.8
Pavlov. Cond. change in total contacts	0.7	1.0	1.8	0.5	0.8	-1.1	1.3
Pavlov. Cond. index score	0.8	1.0	2.1	0.4	0.8	-1.1	1.5
Pavlov. Cond. latency score	0.6	0.8	2.0	0.1	0.6	-0.9	1.4
Pavlov. Cond. lever contacts	1.3	1.8	2.3	1.0	1.3	-1.5	1.4
Pavlov. Cond. magazine entry number	0.6	0.8	2.5	0.1	-0.2	0.8	-1.6
Pavlov. Cond. intertrial magazine entries	2.0	2.6	3.6	-1.3	-1.4	1.8	-1.9
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	2.4	0.5	0.9	-1.2	1.5
Pavlov. Cond. response bias	1.1	1.5	2.0	0.9	1.1	-1.4	1.4
Time in closed arm before self-admin	3.2	3.6	5.1	2.3	1.7	-1.9	1.7
Time in closed arm after self-admin	4.2	4.3	6.8	2.2	1.4	-1.9	2.6
Time in open arm before self-admin	0.5	0.6	0.8	-0.7	-0.7	0.9	-0.8
Time in open arm after self-admin	0.6	0.7	1.2	-0.9	-0.4	0.7	-1.1
Bone: periosteal estimation	0.2	0.3	0.8	0.9	0.4	-0.5	0.5
Bone: periosteal perimeter	0.8	1.3	1.8	1.4	1.2	-1.0	1.0
Bone: post-yield work	0.8	1.1	1.3	0.9	0.9	-1.1	1.2
Progressive ratio test 1 active lever presses	1.1	1.1	1.4	-0.9	-1.2	1.2	-0.9
Progressive ratio test 1 breakpoint	1.1	1.1	1.6	-1.0	-1.2	1.2	-0.8
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.4	0.5	0.6	-0.4	-0.2
Progressive ratio test 2 active lever presses	1.5	1.6	2.1	-0.6	-1.4	1.5	-1.4
Progressive ratio test 2 breakpoint	0.9	1.1	1.4	-0.2	-1.1	1.2	-1.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.5	-0.4	0.3	-0.3
Incentive Sensitization - Responses	0.6	0.6	1.0	0.4	-0.8	0.8	-1.0
Incentive Sensitization - Breakpoint	0.5	0.5	0.9	0.5	-0.6	0.7	-0.9
Sum of active levers in priming session hrs 5-6	4.5	4.4	6.9	-2.6	-2.1	2.1	-1.5
Progressive ratio	0.2	0.2	0.6	0.4	0.1	0.1	-0.8
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.1	0.5	-0.1	-0.4
Seeking ratio, punishment vs. effort	0.3	0.3	0.9	-0.9	-0.4	0.4	0.1
Retroperitoneal fat weight	0.1	0.4	0.9	1.0	0.6	-0.7	0.2
Reaction time number correct	1.7	2.4	2.6	1.5	1.6	-1.5	1.6
Reaction time mean minus median	1.8	2.4	3.4	-1.8	-1.9	1.5	-0.8
Reaction time mean minus median AUC	2.7	3.5	5.1	-2.0	-2.3	1.9	-1.1
Reaction time num false alarms	0.7	0.9	1.2	-1.1	-0.6	1.1	-1.0
Reaction time num false alarms AUC	0.7	1.0	1.3	-1.1	-0.7	1.1	-1.0
Reaction time trials correct on left	1.7	2.4	2.6	1.5	1.6	-1.5	1.6
Reaction time trials on left	1.6	2.3	2.4	1.5	1.6	-1.5	1.5
Reaction time mean	1.0	1.3	2.5	-1.2	-1.6	1.1	-0.3
Reaction time mean AUC	1.2	1.7	3.1	-1.3	-1.8	1.2	-0.4
Median of all reaction times	0.4	0.5	1.2	-0.6	-1.1	0.7	-0.1
Reaction time omissions	1.1	1.4	1.9	-1.4	-1.1	1.3	-1.0
Reaction time false alarm rate	1.7	2.4	2.7	-1.7	-1.3	1.6	-1.6
Reaction time premature initiation rate	0.2	0.3	0.6	-0.7	-0.2	0.5	-0.6
Reaction time premature initiations	0.1	0.1	0.3	-0.0	0.5	-0.2	0.3
Std. dev. reaction times	1.5	2.1	3.2	-1.7	-1.8	1.4	-0.5
Reaction time trials completed	1.6	2.3	2.4	1.5	1.6	-1.5	1.5
Reaction time trials AUC	1.6	2.3	2.5	1.5	1.6	-1.5	1.5
Run reversals in cocaine runway, females	0.1	0.1	0.4	-0.4	-0.1	0.0	0.6
Run reversals in cocaine runway, males	0.8	0.8	1.9	1.4	0.9	-0.6	-0.2
Latency to leave start box in cocaine runway	5.2	5.6	7.4	2.5	1.8	-2.3	2.7
Latency to leave start box in cocaine runway, F	9.0	9.9	13.1	3.0	2.8	-3.1	3.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.3	-0.5	0.2	-0.3
Std. dev. time between licks in bursts	0.7	0.8	1.1	0.9	1.1	-1.0	0.6
Total sessions with >9 infusions	0.6	0.7	1.3	-1.2	-0.8	0.6	-0.6
Short access day 1 total inactive lever presses	0.1	0.1	0.3	-0.5	-0.3	0.3	-0.3
Short access day 10 total inactive lever presses	0.3	0.3	0.8	0.9	0.4	-0.3	0.2
Short access day 1 total infusions	0.1	0.1	0.3	-0.6	-0.0	-0.2	-0.0
Short access day 10 total infusions	0.2	0.2	0.5	0.1	-0.6	0.1	0.7
Short access total infusions	0.1	0.1	0.3	-0.1	-0.1	-0.3	0.5
Short access day 1 locomotion	0.0	0.0	0.0	-0.0	-0.0	-0.2	0.1
Short access day 10 total locomotion	0.7	0.8	1.2	-0.8	-1.1	1.0	-0.5
Short access total locomotion	0.1	0.1	0.2	-0.3	-0.4	0.1	0.2
One hour access (0.3 mA shock)	1.1	1.3	2.1	-0.6	-1.2	1.1	-1.5
Compulsive drug intake	6.4	6.5	8.0	-2.8	-2.5	2.4	-2.4
One hour access (shock baseline)	0.7	0.8	2.2	1.5	0.7	-0.6	0.4
Social response proportion	2.0	2.1	3.0	-1.7	-1.3	1.4	-1.3
Social responses	0.2	0.3	1.0	-0.0	0.3	0.3	-1.0
Social time	0.7	0.9	3.1	0.3	0.4	0.4	-1.8
Soleus weight	1.6	4.8	5.0	2.2	2.2	-2.2	2.1
Bone: stiffness	0.1	0.1	0.3	0.5	-0.1	-0.2	0.1
Tibialis anterior weight	0.1	0.5	1.1	-0.6	-0.2	0.6	-1.1
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.2	-1.1	-1.0	1.0	-0.8
Time to tail flick, vehicle, after self-admin	0.9	1.0	1.1	1.1	1.0	-0.9	1.0
Time to tail flick, test, before self-admin	1.1	1.1	1.4	0.8	1.0	-1.2	1.1
Time to tail flick, test, after self-admin	0.8	0.8	1.2	0.7	0.8	-1.0	1.1
Delta time to tail flick, vehicle, before/after SA	3.0	3.0	3.7	1.9	1.9	-1.7	1.3
Delta time to tail flick, test, before/after SA	0.5	0.4	0.6	-0.8	-0.6	0.6	-0.7
Tibia length	0.7	2.0	2.5	1.4	1.2	-1.6	1.4
Ambulatory time before self-admin	3.0	3.1	6.0	-1.0	-1.3	1.9	-2.5
Ambulatory time after self-admin	0.3	0.3	0.7	0.8	0.7	-0.1	0.4
Bone: tissue strength	1.1	1.1	1.5	1.2	0.8	-1.2	1.0
Total heroin consumption	0.4	0.5	0.7	-0.8	-0.5	0.7	-0.7
Bone: trabecular number	0.0	0.1	0.2	0.4	-0.1	0.1	-0.1
Bone: trabecular spacing	0.2	0.3	0.8	0.1	0.5	0.1	-0.9
Bone: trabecular thickness	4.5	5.4	8.6	2.0	1.8	-2.4	2.9
Bone: trabecular tissue density	0.1	0.1	0.1	-0.2	0.1	-0.4	0.4
Water consumed over 24 hours	0.0	0.0	0.0	-0.2	-0.2	0.2	0.1
Number of responses in last shaping day	2.1	2.2	2.5	1.5	1.6	-1.6	1.2