Hub : Genes

Pgap1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Pgap1 0.16 0.09 1.7e-16 0.13 0.13 0.14 0.14 8.1e-14 2.7e-14 2.2e-15 1.5e-15
2 Brain mRNA stability Pgap1 0.07 0.04 6.7e-06 0.04 0.04 0.04 0.04 6.5e-05 6.2e-05 9.7e-05 1.2e-04
3 Liver mRNA stability Pgap1 0.04 0.03 2.2e-03 0.01 0.01 0.01 0.01 8.4e-03 9.3e-03 2.2e-02 7.6e-03
4 NAcc gene expression Pgap1 0.12 0.07 1.0e-11 0.08 0.09 0.09 0.09 6.0e-10 6.3e-11 5.0e-10 4.9e-11
5 Brain gene expression Pgap1 0.23 0.1 0.0e+00 0.21 0.2 0.22 0.22 4.3e-19 2.5e-18 3.2e-20 1.6e-20
6 Adipose gene expression Pgap1 0.06 0.04 1.1e-05 0.04 0.03 0.04 0.04 9.3e-06 2.3e-04 2.4e-05 1.7e-05
7 PL gene expression Pgap1 0.05 0.03 3.6e-06 0.03 0.03 0.02 0.02 6.5e-04 3.3e-04 2.5e-03 2.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density5.99.813.5-3.7-3.4-3.2-3.2-2.93.2-2.3
Area under the delay curve0.20.20.50.40.40.40.30.5-0.40.7
BMI with tail3.812.214.93.93.53.53.13.4-3.83.2
BMI without tail0.10.20.70.70.5-0.10.90.40.0-0.2
Body weight1.35.67.0-2.2-2.4-2.7-2.1-2.52.0-2.6
Weight adjusted by age0.70.81.5-1.2-0.9-1.0-1.2-0.70.8-0.4
Bone surface5.710.113.5-3.7-3.4-3.3-3.3-2.93.3-2.3
Bone volume6.110.415.3-3.9-3.5-3.3-3.3-2.93.2-2.2
Breakpoint value in progressive ratio session0.10.20.5-0.4-0.4-0.2-0.7-0.3-0.2-0.2
Number of licking bursts0.50.51.10.40.50.80.40.7-1.10.9
Context. condit. distance diff. score1.31.53.11.81.41.21.50.9-0.90.5
Locomotion velocity, session 12.32.43.81.51.71.41.91.9-0.81.5
Locomotion distance, session 10.40.61.30.80.90.41.10.8-0.20.5
Locomotion velocity, session 21.82.13.21.21.61.51.61.8-0.61.6
Locomotion distance, session 20.20.30.50.50.60.50.70.5-0.20.3
Locomotion velocity, session 30.20.20.80.1-0.1-0.30.3-0.40.7-0.9
Locomotion distance, session 30.00.00.10.30.2-0.20.30.00.1-0.1
Stereotopy head waving bouts, day 31.31.63.01.51.31.51.71.0-0.70.4
Stereotopy head waving duration, day 30.30.40.90.80.50.81.00.20.2-0.4
Locomotion velocity, session 72.12.33.71.31.71.31.71.9-0.71.8
Locomotion distance, session 70.10.20.40.40.50.30.30.6-0.30.6
Stereotopy head waving bouts, day 70.10.10.3-0.3-0.1-0.10.00.00.60.0
Stereotopy head waving duration, day 70.10.10.30.10.20.10.40.20.5-0.1
Locomotion velocity, session 81.41.73.31.01.31.11.21.7-0.81.8
Locomotion distance, session 81.21.83.01.71.61.11.71.3-0.90.8
Degree of sensitization distance0.10.10.2-0.3-0.20.1-0.40.1-0.20.5
Degree of sensitization stereotypy0.10.10.2-0.5-0.3-0.3-0.4-0.00.40.2
Conditioned locomotion2.52.93.7-1.9-1.9-1.9-1.8-1.91.0-1.4
Cocaine response after cond. corrected1.61.83.5-1.8-1.5-1.5-1.9-0.80.70.1
Cocaine response after cond. not corrected2.32.54.5-2.1-1.7-1.8-2.1-1.01.2-0.1
Cocaine response before conditioning0.10.10.30.40.40.30.50.30.1-0.0
Saline control response0.10.10.40.60.30.30.4-0.1-0.2-0.4
Bone: connectivity density2.64.16.1-2.5-2.2-2.2-2.1-1.72.1-1.3
Bone: cortical apparent density6.58.611.63.22.92.92.82.7-3.42.5
Bone: cortical area0.20.30.4-0.6-0.6-0.2-0.5-0.60.5-0.5
Bone: cortical porosity5.05.46.8-2.3-2.3-2.5-1.9-2.22.6-2.3
Bone: cortical porosity7.17.89.1-2.8-2.8-3.0-2.5-2.73.0-2.7
Bone: cortical thickness1.22.02.61.51.41.61.41.2-1.61.1
Bone: cortical thickness1.82.13.61.11.31.60.91.5-1.61.9
Bone: cortical tissue density6.78.811.73.23.02.92.82.7-3.42.6
Condit. Reinf. active minus inactive responses0.40.41.3-0.9-0.6-0.5-1.1-0.4-0.20.3
Condit. Reinf. active-inactive response ratio0.10.10.4-0.5-0.00.0-0.30.3-0.20.7
Condit. Reinf. active responses1.11.43.5-1.5-1.3-1.1-1.9-1.00.2-0.1
Condit. Reinf. inactive responses0.50.61.6-0.8-0.9-0.7-1.3-0.80.2-0.3
Incentive salience index mean0.60.72.2-1.2-0.8-0.6-1.5-0.5-0.20.5
Condit. Reinf. lever presses0.50.71.7-1.2-1.0-0.6-1.3-0.80.3-0.1
Condit. Reinf. active minus inactive responses3.84.79.1-2.5-2.5-2.0-3.0-2.11.4-0.9
Condit. Reinf. active-inactive response ratio1.01.12.8-1.4-1.2-0.8-1.7-0.70.10.2
Condit. Reinf. active responses2.02.86.4-1.9-2.0-1.4-2.5-1.70.8-0.4
Condit. Reinf. inactive responses0.10.10.2-0.2-0.3-0.2-0.5-0.30.30.1
Condit. Reinf. lever presses0.50.72.50.10.20.7-0.30.7-1.21.6
Condit. Reinf. lever reinforcers received1.82.56.0-1.9-1.9-1.3-2.4-1.50.7-0.1
Conditioned reinforcement - actives0.10.10.40.20.1-0.20.4-0.30.5-0.6
Conditioned reinforcement - inactives0.00.00.1-0.1-0.1-0.20.1-0.20.4-0.3
Conditioned locomotion0.20.20.80.60.20.50.10.0-0.90.3
Patch foraging indifference point 0 sec1.21.95.10.61.11.20.61.5-1.62.3
Patch foraging indifference point AUC0.10.10.3-0.5-0.3-0.2-0.4-0.20.4-0.2
Delay disc. indifference point, 0s delay2.32.53.01.61.61.71.41.5-1.61.5
Delay disc. indifference point, 16s delay0.10.10.30.10.20.20.20.4-0.20.5
Delay disc. indifference point, 2s delay1.11.22.80.70.71.00.30.9-1.71.6
Delay disc. indifference point, 24s delay0.30.30.60.70.60.40.80.5-0.40.2
Delay disc. indifference point, 4s delay1.11.11.41.21.11.01.11.0-1.01.1
Delay disc. indifference point, 8s delay0.10.10.3-0.4-0.2-0.3-0.2-0.10.6-0.1
Indifference point function ln k1.42.03.51.11.21.30.81.5-1.81.9
Indifference point function log k1.42.03.51.11.21.30.81.5-1.81.9
Patch foraging total patch changes 0 sec1.32.04.90.71.11.30.71.5-1.72.2
Patch foraging total patch changes 12 sec0.30.41.3-0.00.20.5-0.00.6-1.01.1
Patch foraging total patch changes 18 sec2.83.65.41.42.01.71.72.3-1.62.2
Patch foraging total patch changes 24 sec0.00.00.10.00.10.10.10.10.10.3
Patch foraging total patch changes 6 sec0.71.02.30.60.91.20.61.1-0.81.5
Patch foraging time to switch 0 sec0.20.30.80.20.1-0.10.5-0.30.9-0.9
Patch foraging water rate 0 sec0.10.10.6-0.3-0.4-0.1-0.8-0.4-0.10.0
Patch foraging water rate 12 sec0.71.13.20.30.51.0-0.01.0-1.51.8
Patch foraging water rate 18 sec0.40.51.4-0.7-0.9-0.5-1.2-0.8-0.10.0
Patch foraging water rate 24 sec0.10.10.2-0.0-0.2-0.3-0.1-0.20.4-0.4
Patch foraging water rate 6 sec0.10.10.40.1-0.3-0.1-0.7-0.4-0.40.0
Seeking ratio, delayed vs. immediate footshock1.82.02.7-1.4-1.6-1.6-1.6-1.51.2-1.1
Distance traveled before self-admin2.42.53.5-1.8-1.7-1.9-1.8-1.51.3-1.1
Distance traveled after self-admin0.20.21.00.50.30.20.20.2-1.00.5
Extensor digitorum longus weight1.87.212.53.52.93.03.02.3-2.11.3
Bone: elastic displacement0.30.31.20.20.20.4-0.10.4-1.10.8
Bone: elastic work1.41.82.8-1.7-1.5-1.4-1.5-1.20.9-0.8
Bone: endosteal estimation4.910.714.6-3.8-3.5-3.1-3.5-3.13.2-2.5
Bone: endosteal perimeter4.18.611.3-3.4-3.0-2.8-3.0-2.83.1-2.3
Epididymis fat weight2.55.77.9-2.2-2.5-2.3-2.1-2.62.1-2.8
Delta time in closed arm before/after self-admin0.60.61.01.00.91.01.00.60.10.1
Delta time in open arm before/after self-admin4.94.78.1-2.8-2.3-2.2-2.6-1.71.9-1.1
Diff in mean of infusions in LGA sessions0.20.30.7-0.8-0.4-0.5-0.8-0.10.10.2
Delay discount exponential model param0.10.10.4-0.3-0.3-0.3-0.2-0.40.4-0.6
Extinction: sum of active levers before priming1.71.72.2-1.4-1.5-1.2-1.5-1.50.8-1.2
Active lever presses in extinction session 60.80.81.4-1.0-1.0-1.0-1.2-0.80.2-0.5
Bone: final force2.54.15.7-1.8-2.1-1.6-1.9-2.41.8-2.4
Bone: final moment2.03.35.0-1.6-1.9-1.3-1.7-2.21.6-2.2
Food consumed during 24 hour testing period0.20.20.4-0.2-0.5-0.4-0.3-0.60.3-0.6
Glucose0.30.41.40.90.20.40.6-0.6-0.3-1.2
Heart weight0.10.10.3-0.1-0.1-0.1-0.50.2-0.60.5
Delay discount hyperbolic model param0.30.30.7-0.5-0.5-0.5-0.4-0.60.6-0.8
Intermittent access intake day 1-15 change0.20.20.50.70.40.20.50.0-0.5-0.0
Intermittent access intake escalation0.10.10.40.60.30.10.4-0.0-0.4-0.0
Intermittent access intake escalation 20.20.20.3-0.3-0.5-0.6-0.4-0.60.3-0.5
Intermitt. access day 1 inactive lever presses0.80.92.11.41.00.91.10.5-0.90.3
Intermitt. access day 15 inactive lever presses0.00.00.10.30.20.10.30.2-0.20.1
Intermitt. access escalation Index1.31.22.8-0.4-0.9-0.9-0.6-1.51.0-1.7
Intermittent access day 1 total infusions1.61.92.8-1.2-1.5-1.4-1.4-1.70.8-1.5
Intermittent access day 15 total infusions1.01.12.4-0.5-1.1-1.1-0.8-1.60.4-1.4
Intermittent access terminal intake (last 3 days)0.60.71.5-0.5-0.9-0.8-0.7-1.20.1-1.0
Intermittent access total infusions1.71.93.3-1.1-1.5-1.4-1.3-1.80.7-1.6
Intermittent access day 1 locomotion0.00.00.20.0-0.2-0.0-0.1-0.4-0.2-0.2
Intermittent access day 15 total locomotion0.91.01.5-0.9-1.1-1.1-0.9-1.20.6-0.9
Intermittent access total locomotion0.50.51.2-0.4-0.8-0.7-0.6-1.10.3-0.9
Intermittent access standard deviation0.10.10.30.3-0.2-0.3-0.2-0.5-0.4-0.5
Left kidney weight0.20.61.2-1.1-1.0-0.8-0.8-0.80.5-0.6
Right kidney weight0.20.61.3-1.1-0.9-1.0-0.7-0.50.4-0.3
Cocaine induced anxiety0.00.10.10.40.30.10.20.1-0.30.2
Post-drug Anxiety0.10.10.30.10.20.3-0.10.3-0.40.6
Baseline Anxiety0.10.10.3-0.6-0.3-0.2-0.4-0.20.2-0.0
Tail length12.237.143.6-6.1-6.0-6.6-4.9-6.16.4-6.4
Length with tail12.545.751.0-7.0-6.8-7.1-5.8-6.86.9-6.8
Length without tail1.63.44.3-2.0-2.1-1.7-1.9-2.01.5-1.6
Times rat made contact with spout0.10.10.4-0.1-0.1-0.20.2-0.20.4-0.6
Lifetime Intake0.81.02.0-0.6-1.0-1.0-0.7-1.40.5-1.3
Liver weight, left1.01.62.3-1.2-1.3-1.2-1.3-1.31.5-0.9
Liver weight, right0.81.32.1-1.2-1.2-0.9-1.1-1.21.4-0.9
Locomotor activity0.10.20.4-0.1-0.5-0.5-0.6-0.60.3-0.4
Locomotor testing distance0.10.10.20.0-0.1-0.1-0.50.0-0.40.5
Locomotor testing rearing0.30.40.6-0.4-0.6-0.7-0.7-0.70.6-0.7
Locomotion in novel chamber1.21.42.41.31.21.20.81.1-1.51.1
Locomotion in novel chamber post-restriction1.31.62.51.31.31.61.31.2-1.10.9
Fecal boli incidents, locomotor time 11.61.73.1-1.8-1.3-1.5-1.6-0.71.5-0.2
Change in fecal boli incidents, locomotor task0.10.10.20.50.10.40.2-0.2-0.4-0.1
Time >=10cm from walls, locomotor time 10.80.83.3-0.30.40.6-0.31.2-0.31.8
Bouts of movement, locomotor time 10.10.10.1-0.3-0.2-0.3-0.20.10.10.4
Total resting periods, locomotor time 10.40.51.20.30.50.50.50.9-0.61.1
Rest time, locomotor task time 10.10.10.10.20.30.20.30.2-0.40.1
Distance moved, locomotor task time 10.00.00.1-0.3-0.2-0.2-0.2-0.00.20.3
Vertical activity count, locomotor time 10.30.30.80.90.70.50.70.5-0.10.1
Time >=10cm from walls, locomotor time 20.70.82.1-1.5-0.8-0.4-1.3-0.10.00.8
Bouts of movement, locomotor time 21.11.22.60.80.81.00.61.1-1.41.6
Total resting periods, locomotor time 21.11.22.70.80.81.00.61.1-1.41.6
Rest time, locomotor task time 20.10.10.20.40.40.40.40.2-0.0-0.2
Distance moved, locomotor task time 20.10.10.4-0.5-0.3-0.3-0.20.1-0.10.6
Vertical activity count, locomotor time 20.40.40.60.70.60.50.60.6-0.80.7
Light reinforcement 10.91.64.61.61.01.01.20.5-2.10.6
Light reinforcement 20.30.40.6-0.8-0.8-0.5-0.8-0.6-0.80.1
Bone: marrow area4.610.013.7-3.7-3.4-3.0-3.4-3.03.1-2.4
Bone: maximum diameter0.71.21.6-1.2-1.2-1.0-1.2-1.11.3-0.7
Bone: maximum force3.76.47.4-2.6-2.7-2.2-2.4-2.72.4-2.6
Bone: maximum moment3.05.26.5-2.3-2.4-1.9-2.2-2.52.1-2.5
Mean time between licks in bursts0.30.41.00.90.60.51.00.3-0.1-0.4
Mean num. licks in bursts0.30.40.7-0.3-0.4-0.7-0.2-0.60.9-0.9
Cd content in liver0.60.72.0-0.2-0.5-0.7-0.3-0.91.0-1.4
Co content in liver0.60.71.41.11.00.71.20.7-0.60.3
Cu content in liver0.10.20.4-0.6-0.4-0.4-0.5-0.30.00.0
Fe content in liver2.53.04.1-1.9-1.9-1.6-2.0-1.91.3-1.4
K content in liver0.00.00.0-0.10.0-0.1-0.10.1-0.10.2
Mg content in liver0.30.30.6-0.5-0.6-0.7-0.7-0.50.3-0.3
Mn content in liver1.82.02.41.51.51.51.31.4-1.51.2
Na content in liver0.50.51.2-0.9-0.9-0.5-1.1-0.70.60.0
Rb content in liver0.40.51.3-0.7-0.8-0.6-1.1-0.50.50.4
Se content in liver0.20.30.8-0.2-0.6-0.2-0.9-0.8-0.4-0.3
Sr content in liver0.60.62.30.2-0.4-0.40.1-1.10.6-1.5
Zn content in liver0.00.00.1-0.10.0-0.30.3-0.00.2-0.3
Bone: minimum diameter1.01.82.4-1.6-1.5-1.1-1.4-1.51.1-1.0
Time in familiar zone, hab. session 10.20.20.40.50.40.60.70.20.4-0.3
Time in novel zone, hab. session 10.20.20.3-0.5-0.3-0.4-0.5-0.1-0.40.3
Total zone transitions, hab. session 10.30.51.20.20.60.60.61.0-0.31.1
Total locomotion distance, hab. session 10.20.30.9-0.9-0.5-0.3-0.7-0.1-0.10.5
Locomotion velocity, hab. session 10.40.61.2-1.1-0.9-0.8-0.9-0.70.4-0.3
Time in familiar zone, hab. session 21.11.11.60.71.01.01.11.2-1.21.0
Time in novel zone, hab. session 20.70.71.2-0.4-0.8-0.8-1.0-1.10.8-0.9
Total zone transitions, hab. session 20.10.20.50.0-0.0-0.30.3-0.20.7-0.6
Total locomotion distance, hab. session 20.70.91.6-0.9-0.9-1.1-0.5-1.01.0-1.3
Locomotion velocity, hab. session 20.91.22.1-0.9-1.0-1.2-0.5-1.11.3-1.4
Novel to familiar place preference ratio3.33.44.8-2.2-2.1-1.6-2.2-2.01.2-1.5
Novelty place preference3.33.44.6-2.1-2.0-1.6-2.1-2.01.2-1.5
Time in novel zone, NPP test2.72.84.1-1.9-1.9-1.5-2.0-1.81.0-1.3
Total zone transitions, NPP test0.10.20.30.60.50.30.50.4-0.40.3
Total locomotion distance, NPP test0.10.10.6-0.1-0.00.0-0.20.0-0.80.3
Locomotion velocity, NPP test0.00.10.4-0.00.0-0.0-0.10.0-0.60.2
Intraocular pressure3.34.65.52.12.12.32.32.0-2.21.8
Delta distance traveled before/after self-admin1.21.32.21.31.11.21.10.8-1.50.8
Delta ambulatory time before/after self-admin0.60.61.81.00.60.80.70.1-1.30.3
Parametrial fat weight0.00.00.0-0.1-0.1-0.00.1-0.10.0-0.2
Pavlov. Cond. lever latency0.50.71.81.10.90.51.30.60.0-0.2
Pavlov. Cond. magazine entry latency0.40.51.1-1.0-0.7-0.3-1.1-0.3-0.30.5
Pavlov. Cond. change in total contacts0.50.51.7-0.7-0.20.2-0.80.3-0.91.3
Pavlov. Cond. index score0.50.71.7-1.2-1.0-0.5-1.3-0.7-0.20.2
Pavlov. Cond. latency score0.81.02.6-1.4-1.2-0.7-1.6-0.90.00.1
Pavlov. Cond. lever contacts0.60.71.8-1.1-1.0-0.5-1.4-0.7-0.10.1
Pavlov. Cond. magazine entry number0.50.61.71.30.90.51.10.40.0-0.3
Pavlov. Cond. intertrial magazine entries1.21.41.8-0.9-1.2-1.2-1.2-1.41.1-1.3
Pavlov. Cond. lever-magazine prob. diff.0.40.51.1-1.0-0.7-0.3-1.1-0.4-0.40.4
Pavlov. Cond. response bias0.40.51.2-1.1-0.8-0.5-1.0-0.5-0.10.1
Pavlov. Cond. lever latency0.91.23.1-0.4-0.8-1.1-0.5-1.41.1-1.8
Pavlov. Cond. magazine entry latency0.50.51.10.50.80.61.01.0-0.20.6
Pavlov. Cond. change in total contacts0.60.93.3-0.10.40.60.11.1-0.91.8
Pavlov. Cond. index score0.60.82.10.20.60.80.41.1-0.81.4
Pavlov. Cond. latency score0.40.51.50.20.50.70.40.9-0.71.2
Pavlov. Cond. lever contacts0.60.83.00.10.40.8-0.01.0-1.01.7
Pavlov. Cond. magazine entry number0.10.10.30.50.30.20.2-0.0-0.3-0.1
Pavlov. Cond. intertrial magazine entries0.10.10.20.2-0.10.2-0.5-0.3-0.40.1
Pavlov. Cond. lever-magazine prob. diff.0.70.82.30.30.70.90.41.2-0.81.5
Pavlov. Cond. response bias0.20.31.4-0.30.10.3-0.10.7-0.31.2
Time in closed arm before self-admin5.25.98.4-2.7-2.6-2.9-2.5-2.32.2-1.7
Time in closed arm after self-admin0.40.50.9-0.9-0.7-0.8-0.8-0.30.60.1
Time in open arm before self-admin4.34.78.62.92.32.52.41.4-2.10.8
Time in open arm after self-admin0.50.61.0-1.0-0.8-0.4-0.9-0.70.6-0.7
Bone: periosteal estimation3.16.48.4-2.9-2.7-2.3-2.7-2.52.4-2.0
Bone: periosteal perimeter2.23.74.7-2.2-2.1-1.7-2.1-2.01.8-1.5
Bone: post-yield work1.72.33.3-1.4-1.6-1.2-1.3-1.81.5-1.8
Progressive ratio test 1 active lever presses0.30.31.0-0.1-0.4-0.3-0.1-0.80.6-1.0
Progressive ratio test 1 breakpoint0.30.30.9-0.2-0.5-0.4-0.2-0.90.5-1.0
Progressive ratio test 1 inactive lever presses0.91.03.01.70.80.61.4-0.4-0.2-1.1
Progressive ratio test 2 active lever presses0.60.71.6-0.3-0.5-0.9-0.1-1.01.0-1.3
Progressive ratio test 2 breakpoint0.20.20.60.1-0.2-0.40.2-0.60.4-0.8
Progressive ratio test 2 inactive lever presses0.10.10.40.30.0-0.20.4-0.5-0.0-0.6
Incentive Sensitization - Responses0.80.91.4-0.6-0.7-1.2-0.3-1.01.2-1.2
Incentive Sensitization - Breakpoint0.70.71.2-0.5-0.6-1.1-0.2-0.91.1-1.1
Sum of active levers in priming session hrs 5-61.51.42.1-1.4-1.3-1.2-1.5-1.20.8-0.9
Progressive ratio1.01.12.11.11.21.41.41.0-0.50.5
Food seeking constrained by brief footshock0.00.10.2-0.1-0.0-0.20.2-0.10.4-0.3
Seeking ratio, punishment vs. effort1.31.52.6-1.1-1.3-1.6-1.3-1.21.1-1.0
Retroperitoneal fat weight0.20.71.8-0.1-0.8-0.5-0.9-1.30.1-1.2
Reaction time number correct0.60.81.20.90.81.10.60.7-1.11.0
Reaction time mean minus median2.02.64.4-1.3-1.6-1.7-1.4-1.91.1-2.1
Reaction time mean minus median AUC1.01.42.0-1.0-1.1-1.4-1.0-1.30.8-1.4
Reaction time num false alarms3.34.55.72.42.22.22.42.0-2.01.5
Reaction time num false alarms AUC3.75.16.92.62.42.32.62.1-2.01.5
Reaction time trials correct on left0.60.81.20.90.81.10.60.7-1.11.0
Reaction time trials on left0.50.71.10.90.71.00.50.6-1.00.9
Reaction time mean3.34.76.4-2.0-2.1-2.4-1.8-2.21.9-2.5
Reaction time mean AUC3.04.06.3-1.7-2.0-2.3-1.6-2.21.7-2.5
Median of all reaction times2.83.85.0-1.9-1.9-2.2-1.6-1.91.8-2.2
Reaction time omissions1.21.62.6-1.0-1.3-1.2-1.0-1.60.9-1.6
Reaction time false alarm rate1.62.23.51.71.71.41.91.5-1.20.9
Reaction time premature initiation rate2.33.17.10.91.31.70.51.8-2.52.7
Reaction time premature initiations3.24.58.71.41.62.20.92.0-2.82.9
Std. dev. reaction times3.04.25.3-1.9-2.1-2.1-1.9-2.21.7-2.3
Reaction time trials completed0.50.71.10.90.71.00.50.6-1.00.9
Reaction time trials AUC0.50.71.10.90.71.10.60.7-1.00.9
Run reversals in cocaine runway, females0.30.31.20.40.50.41.10.40.5-0.1
Run reversals in cocaine runway, males0.30.31.0-0.10.20.4-0.00.5-0.91.0
Latency to leave start box in cocaine runway6.57.08.12.82.82.82.82.6-2.42.2
Latency to leave start box in cocaine runway, F5.35.87.62.72.62.42.72.3-2.01.8
Latency to leave start box in cocaine runway, M1.61.52.50.91.21.61.21.3-1.01.3
Std. dev. time between licks in bursts2.42.84.31.91.61.91.71.2-2.11.0
Total sessions with >9 infusions0.40.41.21.10.70.60.90.1-0.5-0.2
Short access day 1 total inactive lever presses0.20.30.8-0.2-0.40.0-0.7-0.4-0.90.1
Short access day 10 total inactive lever presses0.00.00.10.30.10.1-0.10.0-0.4-0.0
Short access day 1 total infusions0.10.10.40.1-0.3-0.3-0.0-0.7-0.2-0.6
Short access day 10 total infusions1.21.32.1-1.1-1.3-1.1-1.3-1.50.4-1.1
Short access total infusions0.10.10.40.0-0.3-0.3-0.1-0.6-0.3-0.5
Short access day 1 locomotion0.10.10.40.50.20.30.6-0.20.0-0.4
Short access day 10 total locomotion0.10.10.5-0.2-0.3-0.1-0.4-0.1-0.70.3
Short access total locomotion0.30.30.7-0.2-0.5-0.4-0.2-0.80.5-0.9
One hour access (0.3 mA shock)0.70.81.4-0.9-1.1-0.9-0.9-1.20.1-0.8
Compulsive drug intake0.20.20.40.50.50.60.60.5-0.20.4
One hour access (shock baseline)1.92.33.3-1.4-1.6-1.6-1.7-1.80.6-1.4
Social response proportion5.05.46.5-2.4-2.5-2.4-2.5-2.41.9-1.9
Social responses2.33.05.3-1.1-1.8-1.6-1.7-2.31.2-2.0
Social time1.01.42.5-0.6-1.2-1.3-0.9-1.60.7-1.5
Soleus weight0.10.30.7-0.7-0.7-0.6-0.8-0.50.3-0.1
Bone: stiffness4.16.48.8-2.3-2.5-2.3-2.1-2.82.7-3.0
Tibialis anterior weight0.61.92.71.61.51.41.61.4-1.00.8
Time to tail flick, vehicle, before self-admin0.30.30.70.60.70.60.80.70.00.1
Time to tail flick, vehicle, after self-admin0.10.10.4-0.30.0-0.2-0.10.20.6-0.1
Time to tail flick, test, before self-admin0.70.71.10.70.70.70.70.8-1.10.9
Time to tail flick, test, after self-admin0.60.61.21.10.81.00.90.4-0.4-0.1
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.3-0.3-0.5-0.4-0.30.1-0.3
Delta time to tail flick, test, before/after SA0.10.10.20.40.40.40.40.2-0.1-0.1
Tibia length5.916.621.6-4.2-3.9-4.3-3.4-3.84.7-4.1
Ambulatory time before self-admin1.01.12.2-1.1-1.1-1.5-1.2-0.90.8-0.6
Ambulatory time after self-admin0.70.83.00.90.60.70.40.4-1.70.8
Bone: tissue strength1.61.64.2-0.7-1.0-1.2-0.4-1.31.4-2.0
Total heroin consumption0.10.10.4-0.3-0.4-0.6-0.3-0.30.2-0.4
Bone: trabecular number3.55.57.2-2.7-2.4-2.4-2.2-2.12.6-1.8
Bone: trabecular spacing0.81.11.31.11.11.01.11.2-0.81.0
Bone: trabecular thickness1.61.93.2-1.8-1.6-1.3-1.6-1.21.3-0.7
Bone: trabecular tissue density0.10.10.30.50.30.20.60.0-0.1-0.5
Water consumed over 24 hours0.70.81.10.60.81.00.90.9-1.00.9
Number of responses in last shaping day0.80.92.21.41.00.91.50.4-0.0-0.3