Pfkfb4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	isoform ratio	NM_019333.1	0.02	0.01	8.1e-03	0.01	0.01	0.01	0.01	2.0e-02	4.6e-02	4.6e-02	4.1e-02
2	NAcc	mRNA stability	Pfkfb4	0.03	0.03	1.6e-04	0.03	0.02	0.02	0.03	7.0e-05	1.4e-03	1.3e-03	9.7e-05
3	OFC	gene expression	Pfkfb4	0.19	0.1	1.3e-03	0.07	0.05	0.06	0.05	1.1e-02	2.1e-02	1.6e-02	2.2e-02
4	Liver	gene expression	Pfkfb4	0.05	0.03	5.3e-07	0.04	0.05	0.05	0.04	2.0e-05	2.4e-06	5.4e-06	1.4e-05
5	Liver	alternative polyA	XM_039082014.1	0.03	0.02	9.3e-04	0.02	0.02	0.02	0.02	2.9e-03	1.1e-03	2.9e-03	2.9e-03
6	PL	mRNA stability	Pfkfb4	0.02	0.02	9.0e-03	0.02	0.01	0.01	0.01	3.6e-03	1.3e-02	5.8e-02	1.1e-02
7	BLA	mRNA stability	Pfkfb4	0.06	0.05	3.4e-03	0.04	0.04	0	0.04	5.2e-03	2.0e-03	2.0e-01	5.7e-03
8	Liver	alternative polyA	XM_039082019.1	0.03	0.02	1.5e-03	0.02	0.03	0.03	0.03	2.3e-03	8.3e-04	2.9e-04	4.3e-04
9	PL	gene expression	Pfkfb4	0.02	0.02	8.2e-03	0	0.01	0.01	0	8.0e-02	7.1e-02	1.8e-02	1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.0	0.1	0.5	0.1	0.1	0.2	-0.1	0.1	0.1	-0.7	0.2	-0.2
Area under the delay curve	1.7	1.8	2.5	-1.4	-1.4	-1.2	1.3	1.5	-1.5	0.8	1.6	-1.3
BMI with tail	0.6	1.8	2.9	1.3	1.3	1.5	-1.1	-1.2	1.5	-0.7	-1.7	1.6
BMI without tail	2.1	4.4	5.4	2.1	2.1	2.2	-1.9	-1.9	2.2	-1.6	-2.2	2.3
Body weight	5.8	24.4	29.0	5.1	5.1	5.4	-5.1	-5.3	5.0	-3.8	-5.3	4.0
Weight adjusted by age	0.4	0.4	0.8	0.8	0.8	0.7	-0.7	-0.9	0.6	-0.0	-0.6	-0.1
Bone surface	0.0	0.1	0.2	-0.2	-0.2	-0.2	0.3	0.3	-0.3	0.1	0.3	-0.4
Bone volume	0.0	0.1	0.5	-0.0	-0.0	0.0	0.1	0.2	-0.1	-0.1	0.4	-0.7
Breakpoint value in progressive ratio session	0.3	0.3	0.7	0.4	0.4	0.3	-0.4	-0.3	0.7	-0.6	-0.5	0.9
Number of licking bursts	0.3	0.4	1.4	-0.5	-0.5	-0.6	0.6	0.3	-0.5	1.2	0.1	-0.4
Context. condit. distance diff. score	0.0	0.0	0.1	0.1	0.1	-0.0	-0.0	-0.1	0.1	0.1	0.0	-0.3
Locomotion velocity, session 1	0.2	0.2	1.2	-0.2	-0.2	-0.2	0.2	0.3	-0.2	-0.0	0.7	-1.1
Locomotion distance, session 1	0.9	1.2	1.8	1.2	1.2	1.2	-1.1	-1.0	1.1	-1.3	-0.7	0.4
Locomotion velocity, session 2	0.2	0.3	0.6	-0.4	-0.4	-0.4	0.5	0.5	-0.5	0.6	0.6	-0.8
Locomotion distance, session 2	0.0	0.0	0.1	0.0	0.0	0.0	0.1	0.3	-0.1	-0.3	0.3	-0.1
Locomotion velocity, session 3	0.1	0.1	0.6	0.3	0.3	0.5	-0.3	-0.1	0.3	-0.8	-0.0	0.3
Locomotion distance, session 3	0.9	1.0	1.5	-1.1	-1.1	-1.0	1.1	1.2	-1.0	0.6	1.1	-0.6
Stereotopy head waving bouts, day 3	0.1	0.1	0.4	0.2	0.2	0.1	-0.1	-0.4	0.2	0.6	-0.5	0.2
Stereotopy head waving duration, day 3	0.2	0.2	0.4	0.5	0.5	0.4	-0.4	-0.6	0.4	-0.0	-0.6	0.4
Locomotion velocity, session 7	0.1	0.1	0.7	0.1	0.1	0.2	-0.3	-0.0	0.1	-0.8	-0.1	0.5
Locomotion distance, session 7	0.9	1.2	1.7	-1.2	-1.2	-1.1	1.1	1.3	-1.2	0.6	1.2	-0.7
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.2	0.0	-0.1	0.2	0.1
Stereotopy head waving duration, day 7	0.4	0.4	0.6	0.7	0.7	0.7	-0.6	-0.6	0.8	-0.8	-0.5	0.7
Locomotion velocity, session 8	0.3	0.3	0.6	0.7	0.7	0.6	-0.5	-0.3	0.6	-0.8	-0.2	0.3
Locomotion distance, session 8	0.3	0.5	1.4	0.8	0.8	0.7	-0.6	-0.3	0.7	-1.2	-0.1	0.3
Degree of sensitization distance	0.9	0.9	1.1	1.0	1.0	0.9	-1.0	-1.0	1.0	-0.9	-1.0	0.8
Degree of sensitization stereotypy	0.1	0.1	0.5	0.2	0.2	0.3	-0.3	-0.1	0.3	-0.7	0.0	0.2
Conditioned locomotion	2.7	3.2	4.1	-1.8	-1.8	-2.0	1.8	2.0	-1.8	1.3	2.0	-1.5
Cocaine response after cond. corrected	0.3	0.3	0.6	0.6	0.6	0.4	-0.5	-0.8	0.6	0.3	-0.6	-0.2
Cocaine response after cond. not corrected	1.6	1.7	2.6	1.5	1.5	1.4	-1.4	-1.6	1.5	-0.6	-1.3	0.4
Cocaine response before conditioning	1.2	1.4	2.3	1.1	1.1	1.4	-1.2	-1.1	1.2	-1.5	-1.0	0.9
Saline control response	1.4	1.9	4.0	1.2	1.2	1.3	-1.4	-1.2	1.2	-2.0	-1.0	1.4
Bone: connectivity density	0.2	0.3	0.7	-0.6	-0.6	-0.5	0.5	0.7	-0.6	-0.4	0.8	-0.3
Bone: cortical apparent density	0.2	0.3	0.5	-0.6	-0.6	-0.5	0.5	0.6	-0.5	0.2	0.7	-0.5
Bone: cortical area	0.3	0.5	1.8	-0.5	-0.5	-0.5	0.6	0.3	-0.6	1.3	0.3	-1.0
Bone: cortical porosity	0.1	0.1	0.4	-0.2	-0.2	-0.3	0.1	0.4	-0.2	-0.6	0.6	-0.2
Bone: cortical porosity	0.3	0.3	0.8	-0.4	-0.4	-0.6	0.4	0.6	-0.5	-0.4	0.9	-0.3
Bone: cortical thickness	0.1	0.2	0.7	0.3	0.3	0.3	-0.2	-0.6	0.2	0.8	-0.7	-0.2
Bone: cortical thickness	0.0	0.0	0.1	-0.1	-0.1	-0.0	0.1	0.0	0.0	0.2	-0.0	-0.2
Bone: cortical tissue density	0.2	0.3	0.5	-0.6	-0.6	-0.5	0.5	0.6	-0.5	0.2	0.7	-0.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.2	-0.2	0.1	-0.1	-0.3	-0.2	0.2	-0.1	-0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.0	0.0	0.3	-0.3	-0.6	0.0	0.2	-0.3	-0.6
Condit. Reinf. active responses	0.0	0.0	0.2	-0.2	-0.2	-0.2	0.2	0.1	-0.1	0.4	0.0	-0.1
Condit. Reinf. inactive responses	0.3	0.3	0.6	-0.4	-0.4	-0.8	0.7	0.8	-0.4	0.5	0.4	0.3
Incentive salience index mean	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.3	0.2	-0.4	0.5	0.2	-0.5
Condit. Reinf. lever presses	1.1	1.5	1.8	-1.2	-1.2	-1.3	1.3	1.3	-1.1	1.3	1.2	-0.9
Condit. Reinf. active minus inactive responses	1.6	1.9	2.6	1.3	1.3	1.6	-1.5	-1.5	1.3	-1.2	-1.5	1.2
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.8	1.2	1.2	1.3	-1.2	-1.3	1.2	-0.8	-1.2	0.6
Condit. Reinf. active responses	1.5	2.1	2.6	1.3	1.3	1.6	-1.5	-1.6	1.3	-1.3	-1.6	1.4
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.2	-0.2	-0.0	0.1	0.1	-0.2	-0.0	-0.0	0.2
Condit. Reinf. lever presses	1.9	2.6	3.6	1.5	1.5	1.9	-1.7	-1.8	1.5	-1.4	-1.7	1.4
Condit. Reinf. lever reinforcers received	1.7	2.4	2.9	1.4	1.4	1.7	-1.6	-1.7	1.4	-1.3	-1.7	1.6
Conditioned reinforcement - actives	0.3	0.3	0.5	-0.7	-0.7	-0.7	0.6	0.6	-0.4	0.4	0.7	-0.2
Conditioned reinforcement - inactives	1.5	1.6	3.4	-1.4	-1.4	-1.1	1.2	0.9	-1.2	1.8	0.8	-1.4
Conditioned locomotion	0.3	0.3	0.7	-0.7	-0.7	-0.6	0.5	0.7	-0.6	-0.1	0.8	-0.3
Patch foraging indifference point 0 sec	1.4	2.3	3.7	1.5	1.5	1.3	-1.6	-1.4	1.2	-1.9	-1.4	1.9
Patch foraging indifference point AUC	0.1	0.1	0.6	0.3	0.3	0.3	-0.3	-0.1	0.4	-0.8	0.1	0.0
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.0	-0.0	-0.2	0.1	0.2	-0.0	-0.0	0.1	0.3
Delay disc. indifference point, 16s delay	0.8	0.8	1.4	-0.9	-0.9	-0.9	0.9	1.0	-1.2	0.5	1.0	-0.6
Delay disc. indifference point, 2s delay	0.3	0.3	1.0	-0.6	-0.6	-0.3	0.4	0.5	-0.5	0.3	0.7	-1.0
Delay disc. indifference point, 24s delay	0.9	0.8	1.4	-0.9	-0.9	-0.8	0.8	1.0	-1.2	0.5	1.1	-0.9
Delay disc. indifference point, 4s delay	1.4	1.5	1.9	-1.2	-1.2	-1.2	1.3	1.4	-1.2	1.1	1.4	-1.1
Delay disc. indifference point, 8s delay	2.0	2.1	2.8	-1.5	-1.5	-1.3	1.4	1.5	-1.5	0.8	1.7	-1.5
Indifference point function ln k	0.2	0.3	0.5	-0.6	-0.6	-0.5	0.6	0.6	-0.7	0.6	0.2	-0.1
Indifference point function log k	0.2	0.3	0.5	-0.6	-0.6	-0.5	0.6	0.6	-0.7	0.6	0.2	-0.1
Patch foraging total patch changes 0 sec	1.5	2.5	3.5	1.5	1.5	1.4	-1.6	-1.5	1.3	-1.8	-1.6	1.9
Patch foraging total patch changes 12 sec	1.0	1.3	1.7	1.1	1.1	1.1	-1.2	-1.2	1.0	-1.3	-1.1	1.0
Patch foraging total patch changes 18 sec	1.9	2.5	4.1	1.5	1.5	1.6	-1.7	-1.5	1.5	-2.0	-1.4	1.3
Patch foraging total patch changes 24 sec	2.4	3.0	3.5	1.6	1.6	1.9	-1.9	-1.9	1.7	-1.7	-1.8	1.4
Patch foraging total patch changes 6 sec	0.3	0.5	1.6	0.5	0.5	0.5	-0.7	-0.4	0.4	-1.3	-0.3	0.9
Patch foraging time to switch 0 sec	0.2	0.3	0.9	-0.5	-0.5	-0.5	0.5	0.3	-0.5	0.9	0.3	-0.4
Patch foraging water rate 0 sec	0.2	0.3	0.6	0.5	0.5	0.4	-0.5	-0.5	0.5	-0.4	-0.6	0.8
Patch foraging water rate 12 sec	0.2	0.4	1.3	0.4	0.4	0.4	-0.5	-0.5	0.5	-0.4	-0.8	1.1
Patch foraging water rate 18 sec	0.0	0.1	0.2	0.1	0.1	0.0	-0.0	-0.2	0.3	0.4	-0.1	-0.3
Patch foraging water rate 24 sec	0.6	0.9	1.3	1.0	1.0	1.0	-0.9	-1.0	1.1	-0.7	-0.9	0.7
Patch foraging water rate 6 sec	0.2	0.3	0.5	0.5	0.5	0.6	-0.5	-0.5	0.7	-0.7	-0.6	0.1
Seeking ratio, delayed vs. immediate footshock	1.8	2.0	3.2	-1.3	-1.3	-1.8	1.5	1.7	-1.5	1.0	1.7	-0.5
Distance traveled before self-admin	0.5	0.5	2.8	-0.4	-0.4	-0.2	0.3	0.1	-0.9	0.7	0.6	-1.7
Distance traveled after self-admin	0.9	1.0	3.9	-0.8	-0.8	-0.5	0.6	0.5	-1.3	0.8	1.0	-2.0
Extensor digitorum longus weight	0.2	0.7	1.3	-0.9	-0.9	-0.8	0.8	0.7	-0.8	1.2	0.6	-0.7
Bone: elastic displacement	0.0	0.0	0.1	-0.0	-0.0	0.2	-0.1	-0.3	0.0	0.3	-0.4	-0.2
Bone: elastic work	0.3	0.4	0.7	0.6	0.6	0.8	-0.6	-0.8	0.7	-0.1	-0.8	0.1
Bone: endosteal estimation	0.0	0.1	0.3	0.2	0.2	0.1	-0.3	-0.1	0.2	-0.6	0.0	0.3
Bone: endosteal perimeter	1.1	2.3	2.9	-1.5	-1.5	-1.5	1.5	1.5	-1.6	1.2	1.7	-1.7
Epididymis fat weight	0.1	0.3	0.5	0.6	0.6	0.7	-0.7	-0.7	0.5	-0.4	-0.5	0.2
Delta time in closed arm before/after self-admin	0.2	0.2	0.5	-0.5	-0.5	-0.7	0.6	0.7	-0.2	0.2	0.4	-0.3
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.4	0.4	0.5	-0.5	-0.4	0.3	-0.5	-0.2	0.3
Diff in mean of infusions in LGA sessions	0.4	0.4	1.4	0.3	0.3	0.1	-0.1	-0.3	0.7	0.7	-0.9	1.2
Delay discount exponential model param	2.1	2.2	2.7	1.6	1.6	1.4	-1.5	-1.6	1.6	-0.9	-1.6	1.4
Extinction: sum of active levers before priming	0.1	0.1	0.7	0.2	0.2	0.1	-0.2	-0.1	0.2	-0.5	-0.0	0.9
Active lever presses in extinction session 6	0.3	0.3	1.1	0.2	0.2	0.6	-0.6	-0.4	0.3	-1.1	-0.1	0.0
Bone: final force	0.8	1.3	1.9	1.3	1.3	1.2	-1.2	-1.4	1.1	-0.4	-1.3	0.7
Bone: final moment	1.0	1.7	2.5	1.5	1.5	1.4	-1.3	-1.6	1.2	-0.4	-1.5	0.8
Food consumed during 24 hour testing period	1.3	1.6	2.1	1.2	1.2	1.4	-1.3	-1.4	1.2	-1.1	-1.4	0.9
Glucose	0.3	0.5	1.4	0.8	0.8	0.7	-0.7	-0.5	0.7	-1.2	-0.2	0.1
Heart weight	2.3	3.3	4.6	1.9	1.9	1.9	-1.8	-2.1	1.9	-0.9	-2.1	1.1
Delay discount hyperbolic model param	2.0	2.1	2.7	1.6	1.6	1.3	-1.4	-1.6	1.5	-0.9	-1.6	1.3
Intermittent access intake day 1-15 change	1.0	1.0	2.3	-1.0	-1.0	-0.9	0.9	0.6	-1.3	1.5	0.5	-0.9
Intermittent access intake escalation	1.0	0.9	1.9	-1.0	-1.0	-0.8	0.9	0.6	-1.3	1.4	0.5	-0.9
Intermittent access intake escalation 2	0.3	0.3	0.9	-0.4	-0.4	-0.2	0.2	-0.1	-1.0	0.9	-0.2	-0.4
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.0	0.0	0.2	-0.1	-0.1	0.2	0.0	-0.1	-0.3
Intermitt. access day 15 inactive lever presses	0.6	0.7	1.7	-0.6	-0.6	-0.7	0.8	0.6	-1.0	1.3	0.5	-1.1
Intermitt. access escalation Index	0.0	0.0	0.2	0.2	0.2	0.2	-0.1	0.0	-0.0	-0.4	0.1	-0.1
Intermittent access day 1 total infusions	0.0	0.0	0.3	0.1	0.1	-0.2	0.0	0.1	0.0	-0.0	0.1	0.6
Intermittent access day 15 total infusions	0.4	0.5	1.1	-0.7	-0.7	-0.7	0.6	0.5	-1.0	0.9	0.5	-0.4
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.6	-0.4	-0.4	-0.5	0.4	0.4	-0.8	0.5	0.4	0.0
Intermittent access total infusions	0.4	0.5	0.8	-0.7	-0.7	-0.8	0.6	0.6	-0.9	0.7	0.7	-0.1
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.3	0.3	-0.3	0.1	0.4	0.1
Intermittent access day 15 total locomotion	1.0	1.1	1.6	-1.1	-1.1	-1.1	1.0	1.1	-1.2	0.5	1.2	-0.7
Intermittent access total locomotion	1.1	1.3	2.1	-1.2	-1.2	-1.2	1.1	1.2	-1.4	0.5	1.4	-0.7
Intermittent access standard deviation	0.2	0.2	0.4	0.0	0.0	0.1	-0.2	-0.5	-0.4	0.7	-0.6	0.4
Left kidney weight	1.1	3.1	4.2	2.0	2.0	1.8	-1.7	-1.4	1.7	-2.0	-1.4	1.6
Right kidney weight	0.3	0.8	2.0	1.0	1.0	0.9	-0.9	-0.6	0.8	-1.4	-0.3	0.5
Cocaine induced anxiety	0.1	0.1	0.5	-0.1	-0.1	-0.1	0.2	0.1	-0.2	0.7	0.1	-0.0
Post-drug Anxiety	0.0	0.0	0.2	-0.1	-0.1	-0.2	0.2	0.1	0.2	0.4	0.1	0.1
Baseline Anxiety	0.7	0.8	1.0	-1.0	-1.0	-0.9	0.9	0.9	-0.7	0.6	1.0	-1.0
Tail length	6.1	18.5	20.4	4.5	4.5	4.5	-4.5	-4.5	4.5	-3.9	-4.2	3.6
Length with tail	8.1	29.5	34.7	5.8	5.8	5.7	-5.7	-5.9	5.5	-4.8	-5.4	4.1
Length without tail	5.3	11.5	15.0	3.6	3.6	3.7	-3.7	-3.9	3.3	-2.9	-3.5	2.2
Times rat made contact with spout	0.6	0.7	0.9	0.8	0.8	0.9	-0.9	-1.0	0.8	-0.6	-0.9	0.5
Lifetime Intake	0.4	0.5	0.8	-0.7	-0.7	-0.8	0.6	0.7	-0.9	0.5	0.7	-0.2
Liver weight, left	0.1	0.2	0.8	0.4	0.4	0.1	-0.3	-0.1	0.4	-0.9	-0.1	0.8
Liver weight, right	1.5	2.4	3.7	1.7	1.7	1.5	-1.6	-1.4	1.7	-1.9	-1.1	1.3
Locomotor activity	5.4	8.6	9.8	3.1	3.1	3.1	-3.0	-3.0	3.0	-2.7	-2.9	2.3
Locomotor testing distance	4.7	7.8	9.0	3.0	3.0	2.9	-2.9	-2.8	2.9	-2.6	-2.7	2.3
Locomotor testing rearing	0.0	0.1	0.1	0.3	0.3	0.2	-0.3	-0.3	0.3	-0.2	-0.3	0.0
Locomotion in novel chamber	0.1	0.1	0.4	-0.4	-0.4	-0.3	0.3	0.2	-0.3	0.6	0.3	-0.6
Locomotion in novel chamber post-restriction	0.5	0.6	1.3	0.7	0.7	0.8	-0.8	-0.7	0.8	-1.1	-0.6	0.5
Fecal boli incidents, locomotor time 1	0.9	1.0	2.7	1.1	1.1	0.6	-0.8	-0.8	0.9	-0.5	-1.0	1.6
Change in fecal boli incidents, locomotor task	0.2	0.2	1.0	-0.4	-0.4	0.2	0.1	0.1	-0.1	-0.2	0.2	-1.0
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	-0.6	-0.6	-0.6	0.5	0.7	-0.9	0.0	0.6	-0.5
Bouts of movement, locomotor time 1	0.2	0.2	0.6	0.4	0.4	0.3	-0.3	-0.3	0.4	-0.1	-0.6	0.8
Total resting periods, locomotor time 1	0.1	0.1	0.3	0.3	0.3	0.3	-0.2	-0.2	0.3	-0.1	-0.5	0.6
Rest time, locomotor task time 1	0.4	0.4	0.8	-0.6	-0.6	-0.9	0.8	0.9	-0.5	0.5	0.6	0.1
Distance moved, locomotor task time 1	1.1	1.2	1.9	1.1	1.1	1.3	-1.2	-1.4	1.1	-0.8	-1.1	0.1
Vertical activity count, locomotor time 1	0.9	0.9	1.4	1.2	1.2	1.0	-1.0	-1.1	1.0	-0.8	-0.9	0.2
Time >=10cm from walls, locomotor time 2	1.1	1.2	1.5	1.2	1.2	1.0	-1.2	-1.2	1.0	-1.1	-1.0	0.8
Bouts of movement, locomotor time 2	0.2	0.2	0.7	-0.5	-0.5	-0.1	0.2	0.1	-0.2	0.5	0.4	-0.8
Total resting periods, locomotor time 2	0.4	0.4	0.9	-0.8	-0.8	-0.4	0.5	0.4	-0.5	0.7	0.7	-1.0
Rest time, locomotor task time 2	0.0	0.0	0.1	0.0	0.0	-0.2	0.2	0.3	0.2	0.0	0.2	0.1
Distance moved, locomotor task time 2	0.6	0.7	1.3	0.7	0.7	1.1	-1.0	-1.1	0.5	-0.7	-0.8	-0.4
Vertical activity count, locomotor time 2	0.1	0.1	0.6	0.3	0.3	0.2	-0.3	-0.3	-0.1	-0.2	0.1	-0.8
Light reinforcement 1	0.7	1.3	2.0	1.4	1.4	1.1	-1.1	-1.1	1.1	-1.0	-1.0	0.9
Light reinforcement 2	0.1	0.1	0.3	-0.1	-0.1	-0.3	0.3	0.5	-0.1	-0.2	0.5	0.0
Bone: marrow area	0.0	0.1	0.4	0.3	0.3	0.2	-0.3	-0.2	0.2	-0.6	-0.0	0.4
Bone: maximum diameter	0.4	0.8	1.9	-0.7	-0.7	-0.8	0.8	0.6	-0.8	1.4	0.6	-1.0
Bone: maximum force	0.6	1.0	1.4	1.1	1.1	1.0	-1.0	-1.2	0.9	-0.6	-1.1	0.8
Bone: maximum moment	0.7	1.2	1.6	1.2	1.2	1.1	-1.1	-1.3	1.0	-0.5	-1.2	0.8
Mean time between licks in bursts	1.4	2.0	2.2	-1.5	-1.5	-1.3	1.4	1.4	-1.5	1.3	1.4	-1.4
Mean num. licks in bursts	0.9	1.1	2.6	1.0	1.0	1.2	-1.1	-0.9	1.0	-1.6	-0.6	0.6
Cd content in liver	1.9	2.1	3.1	1.4	1.4	1.4	-1.6	-1.8	1.4	-1.0	-1.7	1.3
Co content in liver	0.1	0.1	0.4	-0.5	-0.5	-0.2	0.2	0.0	-0.4	0.6	-0.0	-0.3
Cu content in liver	4.5	5.4	6.3	2.5	2.5	2.1	-2.2	-2.2	2.5	-2.3	-2.3	2.5
Fe content in liver	1.5	1.8	2.4	1.3	1.3	1.2	-1.4	-1.5	1.3	-0.9	-1.6	1.5
K content in liver	1.6	1.6	2.2	1.5	1.5	1.1	-1.1	-1.0	1.5	-1.1	-1.1	1.5
Mg content in liver	0.1	0.2	0.4	0.5	0.5	0.2	-0.1	-0.0	0.5	-0.3	-0.2	0.6
Mn content in liver	0.6	0.6	1.7	0.8	0.8	1.0	-0.8	-0.6	0.8	-1.3	-0.4	0.2
Na content in liver	0.4	0.5	1.0	0.6	0.6	0.5	-0.7	-0.6	0.6	-0.9	-0.6	1.0
Rb content in liver	0.5	0.6	1.2	0.6	0.6	0.6	-0.9	-1.1	0.6	-0.3	-1.1	0.9
Se content in liver	0.2	0.3	0.5	0.6	0.6	0.5	-0.3	-0.3	0.6	-0.3	-0.4	0.7
Sr content in liver	0.0	0.0	0.1	0.2	0.2	0.3	-0.1	-0.0	0.2	-0.2	-0.1	0.1
Zn content in liver	5.1	5.6	6.3	2.5	2.5	2.3	-2.3	-2.3	2.5	-2.2	-2.3	2.4
Bone: minimum diameter	0.5	0.9	1.4	-0.9	-0.9	-0.9	0.9	0.9	-1.0	1.0	1.0	-1.2
Time in familiar zone, hab. session 1	1.6	1.5	2.3	-1.2	-1.2	-1.4	1.3	1.2	-1.2	1.5	1.0	-0.8
Time in novel zone, hab. session 1	0.7	0.7	1.0	0.8	0.8	1.0	-0.9	-0.9	0.7	-0.9	-0.7	0.5
Total zone transitions, hab. session 1	0.6	0.8	1.5	1.0	1.0	1.0	-0.9	-0.7	0.8	-1.2	-0.6	0.7
Total locomotion distance, hab. session 1	0.4	0.5	0.7	0.8	0.8	0.7	-0.6	-0.5	0.8	-0.8	-0.6	0.7
Locomotion velocity, hab. session 1	0.4	0.6	1.0	0.9	0.9	0.8	-0.7	-0.5	0.8	-1.0	-0.6	0.8
Time in familiar zone, hab. session 2	0.8	0.9	1.7	-0.9	-0.9	-0.9	0.9	0.8	-0.8	1.3	0.7	-1.0
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.1	0.1	0.2	-0.3	-0.1	-0.0	-0.6	0.0	0.1
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.4	0.4	0.4	-0.3	-0.2	0.3	-0.3	-0.1	-0.0
Total locomotion distance, hab. session 2	0.5	0.7	1.0	1.0	1.0	0.8	-0.7	-0.6	1.0	-0.8	-0.7	0.9
Locomotion velocity, hab. session 2	0.4	0.6	0.9	0.9	0.9	0.7	-0.6	-0.5	0.9	-0.8	-0.6	0.8
Novel to familiar place preference ratio	1.0	1.1	3.9	0.9	0.9	0.9	-0.9	-0.5	0.8	-2.0	-0.4	1.1
Novelty place preference	1.1	1.1	4.2	0.9	0.9	0.9	-0.9	-0.5	0.8	-2.1	-0.3	1.1
Time in novel zone, NPP test	1.2	1.3	4.2	1.0	1.0	1.0	-1.1	-0.7	0.9	-2.0	-0.5	1.2
Total zone transitions, NPP test	2.6	3.7	5.1	2.1	2.1	2.1	-1.9	-1.6	2.0	-2.3	-1.5	1.7
Total locomotion distance, NPP test	1.4	1.9	2.4	1.5	1.5	1.4	-1.3	-1.2	1.5	-1.4	-1.3	1.4
Locomotion velocity, NPP test	1.5	2.1	2.6	1.6	1.6	1.5	-1.4	-1.2	1.6	-1.5	-1.3	1.4
Intraocular pressure	0.7	1.0	1.5	1.0	1.0	0.8	-1.1	-1.0	1.1	-1.2	-0.8	0.9
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1	0.2	-0.3	-0.0	0.2	-0.0
Delta ambulatory time before/after self-admin	0.4	0.4	0.9	0.6	0.6	0.9	-0.7	-0.6	0.6	-0.8	-0.5	0.3
Parametrial fat weight	1.1	2.2	2.6	1.5	1.5	1.5	-1.6	-1.5	1.4	-1.6	-1.3	1.5
Pavlov. Cond. lever latency	4.4	5.5	6.5	2.3	2.3	2.5	-2.6	-2.5	2.3	-2.5	-2.2	1.9
Pavlov. Cond. magazine entry latency	6.1	7.8	9.6	-2.8	-2.8	-2.9	2.9	2.8	-2.8	3.1	2.5	-2.4
Pavlov. Cond. change in total contacts	1.8	1.9	2.6	-1.4	-1.4	-1.4	1.4	1.3	-1.4	1.6	1.1	-1.1
Pavlov. Cond. index score	5.7	7.3	9.4	-2.7	-2.7	-2.8	2.9	2.8	-2.7	3.1	2.4	-2.1
Pavlov. Cond. latency score	5.6	7.1	8.5	-2.6	-2.6	-2.8	2.9	2.7	-2.7	2.9	2.4	-2.2
Pavlov. Cond. lever contacts	2.2	2.6	3.4	-1.6	-1.6	-1.7	1.8	1.8	-1.6	1.8	1.5	-1.2
Pavlov. Cond. magazine entry number	6.8	8.5	10.1	3.0	3.0	3.1	-3.1	-3.0	2.9	-3.2	-2.6	2.2
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.4	0.6	0.6	0.5	-0.6	-0.5	0.5	-0.7	-0.5	0.6
Pavlov. Cond. lever-magazine prob. diff.	5.2	6.4	9.3	-2.6	-2.6	-2.7	2.7	2.5	-2.5	3.1	2.1	-1.9
Pavlov. Cond. response bias	6.3	7.6	10.1	-2.8	-2.8	-2.9	3.0	2.8	-2.7	3.2	2.4	-2.2
Pavlov. Cond. lever latency	0.2	0.3	0.5	-0.4	-0.4	-0.7	0.6	0.7	-0.5	0.5	0.6	-0.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.3	-0.3	-0.3	0.4	0.3	-0.3	0.5	0.3	-0.3
Pavlov. Cond. change in total contacts	1.9	2.6	3.2	1.6	1.6	1.8	-1.7	-1.8	1.6	-1.2	-1.7	1.5
Pavlov. Cond. index score	0.0	0.1	0.1	0.2	0.2	0.3	-0.2	-0.3	0.2	0.1	-0.3	0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	0.1	0.1	0.3	-0.2	-0.2	0.2	0.1	-0.3	0.3
Pavlov. Cond. lever contacts	0.7	1.0	1.4	1.0	1.0	1.2	-1.1	-1.1	1.0	-1.0	-0.9	0.8
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	0.7	0.7	0.6	-0.7	-0.6	0.6	-0.8	-0.6	0.5
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.9	-0.9	-0.9	-0.9	0.8	0.7	-0.9	0.7	0.6	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.2	0.2	0.3	-0.2	-0.3	0.2	0.1	-0.2	0.1
Pavlov. Cond. response bias	0.0	0.0	0.1	0.1	0.1	0.3	-0.1	-0.2	0.1	0.0	-0.1	-0.1
Time in closed arm before self-admin	1.3	1.5	3.1	0.9	0.9	1.2	-1.3	-1.3	0.5	-1.0	-1.5	1.8
Time in closed arm after self-admin	0.0	0.0	0.1	-0.1	-0.1	-0.3	0.1	0.0	-0.1	0.1	-0.1	0.0
Time in open arm before self-admin	0.7	0.8	1.6	-0.5	-0.5	-0.9	1.0	1.0	-0.6	0.9	1.1	-1.3
Time in open arm after self-admin	0.2	0.2	0.7	-0.3	-0.3	-0.3	0.4	0.6	-0.5	-0.4	0.8	-0.6
Bone: periosteal estimation	0.0	0.0	0.1	0.0	0.0	-0.0	0.0	-0.1	-0.1	0.3	0.0	-0.2
Bone: periosteal perimeter	1.3	2.2	3.2	-1.4	-1.4	-1.4	1.4	1.3	-1.5	1.6	1.5	-1.8
Bone: post-yield work	0.1	0.1	0.7	0.4	0.4	0.2	-0.2	-0.1	0.3	-0.2	-0.4	0.8
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.2	-0.2	-0.0	0.0	0.2	-0.2	-0.4	0.3	0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	-0.3	-0.3	-0.1	0.1	0.3	-0.2	-0.3	0.4	0.0
Progressive ratio test 1 inactive lever presses	0.4	0.5	0.9	-0.8	-0.8	-0.5	0.6	0.5	-0.7	0.9	0.4	-0.7
Progressive ratio test 2 active lever presses	0.7	0.8	1.0	-1.0	-1.0	-0.9	0.9	0.9	-1.0	0.8	1.0	-0.6
Progressive ratio test 2 breakpoint	0.5	0.5	0.7	-0.8	-0.8	-0.7	0.7	0.7	-0.8	0.7	0.8	-0.4
Progressive ratio test 2 inactive lever presses	1.7	2.0	4.0	-1.4	-1.4	-1.2	1.4	1.1	-1.5	2.0	1.0	-1.5
Incentive Sensitization - Responses	1.4	1.4	1.9	-1.3	-1.3	-1.1	1.2	1.1	-1.1	1.4	1.1	-1.1
Incentive Sensitization - Breakpoint	1.3	1.4	1.9	-1.2	-1.2	-1.1	1.2	1.1	-1.1	1.4	1.1	-1.1
Sum of active levers in priming session hrs 5-6	0.8	0.8	1.1	0.9	0.9	0.9	-0.9	-0.8	0.8	-1.0	-0.8	1.1
Progressive ratio	3.2	3.7	4.9	2.2	2.2	2.1	-2.1	-2.1	1.9	-2.2	-1.3	0.5
Food seeking constrained by brief footshock	1.3	1.6	4.3	-1.1	-1.1	-0.9	1.1	1.0	-1.5	0.9	1.3	-2.1
Seeking ratio, punishment vs. effort	5.4	6.6	8.1	-2.8	-2.8	-2.6	2.7	2.6	-2.8	2.8	2.0	-1.6
Retroperitoneal fat weight	0.4	1.4	1.9	1.2	1.2	1.0	-1.2	-1.1	1.1	-1.4	-1.1	1.3
Reaction time number correct	1.1	1.5	4.3	-1.1	-1.1	-1.0	1.0	0.9	-1.1	1.0	1.4	-2.1
Reaction time mean minus median	0.1	0.2	0.5	0.5	0.5	0.4	-0.4	-0.3	0.7	-0.5	-0.2	0.1
Reaction time mean minus median AUC	0.3	0.4	0.8	0.6	0.6	0.7	-0.6	-0.5	0.9	-0.7	-0.4	0.2
Reaction time num false alarms	0.4	0.5	0.7	-0.7	-0.7	-0.7	0.6	0.7	-0.8	0.5	0.8	-0.8
Reaction time num false alarms AUC	0.1	0.1	0.3	-0.4	-0.4	-0.3	0.3	0.3	-0.5	0.0	0.4	-0.4
Reaction time trials correct on left	1.1	1.5	4.3	-1.1	-1.1	-1.0	1.0	0.9	-1.1	1.0	1.4	-2.1
Reaction time trials on left	1.1	1.5	4.2	-1.1	-1.1	-1.0	1.0	1.0	-1.1	1.0	1.4	-2.1
Reaction time mean	0.0	0.0	0.3	-0.1	-0.1	-0.1	0.0	0.1	-0.1	-0.2	0.0	0.6
Reaction time mean AUC	0.0	0.1	0.2	-0.2	-0.2	-0.1	0.1	0.2	-0.2	-0.2	0.1	0.5
Median of all reaction times	0.1	0.1	0.2	-0.4	-0.4	-0.2	0.1	0.2	-0.4	-0.1	0.2	0.4
Reaction time omissions	0.3	0.4	0.6	-0.8	-0.8	-0.8	0.5	0.5	-0.8	0.4	0.5	-0.1
Reaction time false alarm rate	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.0	0.0	-0.1	-0.1	-0.1	0.3
Reaction time premature initiation rate	2.1	2.7	3.7	1.6	1.6	1.9	-1.8	-1.8	1.3	-1.7	-1.7	1.3
Reaction time premature initiations	0.7	0.9	1.7	0.9	0.9	1.3	-1.2	-1.2	0.6	-1.0	-0.9	0.1
Std. dev. reaction times	0.1	0.2	0.5	0.3	0.3	0.3	-0.4	-0.2	0.4	-0.7	-0.2	0.5
Reaction time trials completed	1.1	1.5	4.2	-1.1	-1.1	-1.0	1.0	1.0	-1.1	1.0	1.4	-2.1
Reaction time trials AUC	1.3	1.9	5.0	-1.3	-1.3	-1.2	1.1	1.1	-1.2	1.1	1.6	-2.2
Run reversals in cocaine runway, females	2.8	2.7	3.5	-1.8	-1.8	-1.4	1.7	1.5	-1.9	1.6	1.2	-1.8
Run reversals in cocaine runway, males	0.9	0.9	1.3	1.2	1.2	0.8	-1.0	-1.1	0.7	-0.4	-1.1	0.6
Latency to leave start box in cocaine runway	0.7	0.7	1.0	1.0	1.0	0.7	-0.8	-0.8	1.0	-0.6	-0.7	0.8
Latency to leave start box in cocaine runway, F	1.3	1.4	2.0	1.2	1.2	1.2	-1.2	-1.4	1.3	-0.5	-1.4	0.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.5	0.1	0.1	-0.3	0.2	0.4	-0.1	-0.2	0.7	0.0
Std. dev. time between licks in bursts	5.1	6.1	8.8	-2.4	-2.4	-2.5	2.5	2.3	-2.5	3.0	2.1	-2.3
Total sessions with >9 infusions	0.2	0.2	0.8	-0.4	-0.4	-0.5	0.5	0.3	-0.3	0.9	0.2	-0.2
Short access day 1 total inactive lever presses	5.9	6.5	7.6	-2.8	-2.8	-2.6	2.6	2.5	-2.3	2.5	2.4	-2.6
Short access day 10 total inactive lever presses	0.1	0.1	0.7	0.1	0.1	0.3	-0.1	-0.4	0.4	0.8	-0.5	-0.1
Short access day 1 total infusions	1.1	1.2	1.5	-1.2	-1.2	-1.2	1.1	1.1	-0.8	1.1	1.1	-0.9
Short access day 10 total infusions	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.3	0.4	-0.5	0.1	0.4	-0.1
Short access total infusions	0.9	1.0	1.2	-1.1	-1.1	-1.1	1.0	1.0	-1.1	0.6	1.1	-0.7
Short access day 1 locomotion	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.2	0.2	-0.0	0.2	0.2	-0.4
Short access day 10 total locomotion	0.1	0.1	0.3	-0.2	-0.2	0.0	-0.1	0.0	-0.2	-0.6	0.2	0.1
Short access total locomotion	0.0	0.0	0.3	-0.1	-0.1	0.0	-0.1	0.1	-0.1	-0.5	0.2	0.2
One hour access (0.3 mA shock)	0.3	0.4	0.8	-0.6	-0.6	-0.6	0.5	0.7	-0.9	0.1	0.8	-0.3
Compulsive drug intake	0.2	0.2	0.4	-0.4	-0.4	-0.4	0.4	0.6	-0.2	-0.3	0.6	-0.5
One hour access (shock baseline)	0.0	0.1	0.2	-0.1	-0.1	-0.1	0.1	0.0	-0.4	0.3	0.1	0.4
Social response proportion	0.3	0.3	0.6	0.4	0.4	0.6	-0.7	-0.7	0.3	-0.6	-0.7	0.3
Social responses	0.4	0.5	0.7	0.7	0.7	0.8	-0.8	-0.8	0.8	-0.9	-0.5	0.0
Social time	0.5	0.6	1.7	-0.6	-0.6	-0.8	0.7	0.4	-0.7	1.3	0.6	-0.9
Soleus weight	3.6	10.5	11.9	3.4	3.4	3.4	-3.3	-3.4	3.5	-2.6	-3.4	2.6
Bone: stiffness	0.1	0.2	0.3	0.5	0.5	0.4	-0.4	-0.5	0.3	-0.3	-0.4	0.4
Tibialis anterior weight	0.0	0.0	0.1	0.0	0.0	0.1	-0.1	-0.2	0.1	0.3	-0.2	0.1
Time to tail flick, vehicle, before self-admin	2.3	2.4	3.9	1.6	1.6	1.3	-1.4	-1.4	1.6	-1.3	-1.6	2.0
Time to tail flick, vehicle, after self-admin	0.7	0.8	1.5	0.9	0.9	1.0	-1.0	-1.2	0.6	-0.3	-1.0	0.7
Time to tail flick, test, before self-admin	0.4	0.4	1.4	0.3	0.3	0.4	-0.5	-0.2	0.4	-1.0	-0.4	1.2
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.0	0.0	-0.0	0.1	-0.0	-0.0	0.4	-0.2	0.5
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.1	-0.8	-0.8	-0.5	0.6	0.4	-0.9	1.1	0.6	-0.8
Delta time to tail flick, test, before/after SA	0.3	0.3	0.8	-0.5	-0.5	-0.5	0.6	0.4	-0.5	0.9	0.3	-0.1
Tibia length	6.9	19.3	22.4	4.7	4.7	4.7	-4.5	-4.5	4.6	-3.8	-4.3	3.6
Ambulatory time before self-admin	0.4	0.4	0.8	-0.7	-0.7	-0.6	0.6	0.4	-0.8	0.9	0.4	-0.6
Ambulatory time after self-admin	0.6	0.6	3.2	-0.5	-0.5	-0.0	0.2	0.3	-1.1	0.1	0.8	-1.8
Bone: tissue strength	2.5	2.4	3.6	1.6	1.6	1.6	-1.6	-1.8	1.5	-0.8	-1.9	1.6
Total heroin consumption	0.9	1.1	1.9	1.0	1.0	1.4	-1.1	-1.3	0.9	-0.6	-1.3	0.6
Bone: trabecular number	0.7	1.1	2.0	-1.0	-1.0	-0.9	1.0	1.2	-1.0	0.1	1.4	-1.2
Bone: trabecular spacing	1.4	1.8	3.2	1.3	1.3	1.2	-1.3	-1.6	1.3	-0.4	-1.8	1.5
Bone: trabecular thickness	0.1	0.1	0.6	0.3	0.3	0.3	-0.2	-0.0	0.3	-0.8	0.2	-0.3
Bone: trabecular tissue density	0.4	0.5	0.9	0.7	0.7	0.6	-0.7	-0.6	0.7	-0.8	-0.7	1.0
Water consumed over 24 hours	0.1	0.1	0.3	0.1	0.1	0.1	-0.0	-0.2	0.1	0.6	-0.2	-0.4
Number of responses in last shaping day	0.6	0.6	1.3	-0.7	-0.7	-0.8	0.8	0.7	-0.6	1.1	0.7	-0.6