Hub : Genes

Pes1

pescadillo ribosomal biogenesis factor 1

chr14:83074346–83090726 (+)

Pes1 RatGTEx page

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Pes1 0.04 0.03 6.0e-05 0.03 0.04 0.03 0.03 5.2e-04 4.3e-05 1.1e-04 2.0e-04
2 pVTA mRNA stability Pes1 0.04 0.02 7.8e-04 0.03 0.04 0.05 0.05 1.0e-03 2.3e-04 7.2e-05 1.1e-04
3 IL mRNA stability Pes1 0.21 0.1 3.8e-04 0.1 0.12 0.09 0.11 2.8e-03 9.1e-04 3.6e-03 1.6e-03
4 NAcc intron excision ratio chr14_83079752_83080593 0.02 0.01 2.5e-03 0.01 0.02 0.01 0.01 2.3e-03 1.6e-03 6.2e-03 1.9e-03
5 Brain mRNA stability Pes1 0.21 0.07 0.0e+00 0.28 0.3 0.3 0.31 1.2e-26 1.6e-28 1.7e-28 5.9e-29
6 Liver mRNA stability Pes1 0.05 0.03 1.4e-05 0.05 0.03 0.04 0.04 2.0e-06 6.6e-04 2.0e-05 1.1e-05
7 OFC gene expression Pes1 0.19 0.11 2.8e-03 0.09 0.11 0.04 0.1 4.0e-03 1.6e-03 3.6e-02 2.0e-03
8 PL mRNA stability Pes1 0.09 0.04 3.3e-11 0.11 0.1 0.1 0.11 6.9e-12 1.5e-11 2.4e-11 1.0e-11
9 NAcc mRNA stability Pes1 0.05 0.02 6.0e-07 0.04 0.03 0.04 0.04 4.9e-07 1.1e-05 7.3e-07 2.5e-06
10 pVTA gene expression Pes1 0.07 0.04 1.1e-05 0.07 0.05 0.05 0.06 4.6e-06 1.0e-04 6.1e-05 1.2e-05
11 PL intron excision ratio chr14_83079752_83080593 0.05 0.02 3.0e-06 0.08 0.05 0.08 0.08 2.3e-09 1.6e-06 5.8e-09 7.2e-09
12 Brain intron excision ratio chr14_83074383_83079673 0.03 0.02 8.6e-03 0.01 0.02 0.02 0.01 3.0e-02 5.8e-03 2.6e-03 2.2e-02
13 pVTA intron excision ratio chr14_83079752_83080593 0.03 0.02 5.3e-03 0.02 0.02 0.02 0.02 9.0e-03 1.4e-02 6.1e-03 9.4e-03
14 Adipose mRNA stability Pes1 0.13 0.06 2.9e-15 0.13 0.13 0.13 0.13 6.2e-14 2.1e-14 7.2e-14 1.9e-14
15 Adipose gene expression Pes1 0.04 0.03 9.6e-03 -0 0 -0 -0 8.1e-01 1.6e-01 5.4e-01 7.6e-01
16 NAcc gene expression Pes1 0.05 0.03 6.3e-04 0 0 0.01 0 4.4e-02 2.5e-01 1.8e-02 2.4e-01
17 BLA mRNA stability Pes1 0.05 0.03 6.5e-03 0.02 0.03 0.04 0.02 3.0e-02 8.8e-03 3.4e-03 2.2e-02
18 LHb mRNA stability Pes1 0.17 0.1 8.1e-03 0.18 0.02 0.05 0.13 4.4e-05 8.7e-02 2.6e-02 4.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Bone: apparent density0.61.04.3-0.8-1.5-0.6-1.2-0.7-1.2-0.40.1-0.80.1-1.2-1.6-1.0-0.7-2.1-0.0-0.2-1.1
Area under the delay curve8.49.715.02.93.23.23.43.22.83.02.53.52.33.62.13.93.32.82.63.33.9
BMI with tail0.93.09.82.02.11.82.21.01.31.60.41.80.71.91.71.91.53.10.51.52.1
BMI without tail0.41.14.01.91.41.41.40.50.61.10.40.80.60.80.80.80.22.0-0.40.50.9
Body weight3.013.321.74.74.54.44.53.52.94.03.03.73.13.52.93.73.14.02.63.23.5
Weight adjusted by age1.62.43.71.91.91.81.81.51.11.61.21.71.01.71.51.81.31.41.01.41.8
Bone surface0.10.10.30.3-0.00.40.20.50.20.40.50.50.40.2-0.10.20.4-0.10.30.50.2
Bone volume0.10.10.60.0-0.60.1-0.20.1-0.20.20.50.00.4-0.4-0.7-0.3-0.0-0.80.30.2-0.4
Breakpoint value in progressive ratio session0.20.20.80.4-0.10.40.40.30.10.60.40.50.40.5-0.10.50.50.10.90.50.5
Number of licking bursts0.91.43.21.71.01.41.11.11.31.31.80.41.70.3-0.21.10.20.01.21.41.5
Context. condit. distance diff. score1.82.24.8-1.5-1.6-1.5-1.7-1.9-2.2-1.4-1.4-1.6-1.5-1.4-1.2-1.3-1.4-1.0-1.5-1.2-0.9
Locomotion velocity, session 10.80.93.0-1.7-0.4-1.5-0.7-0.6-0.3-1.4-1.6-0.2-1.7-0.10.8-0.4-0.10.4-0.7-1.0-0.2
Locomotion distance, session 10.91.23.5-1.3-1.4-1.1-1.4-1.2-1.9-1.0-0.8-0.8-0.8-0.8-1.1-0.8-0.9-1.2-1.2-0.5-0.5
Locomotion velocity, session 21.72.07.4-2.7-1.2-2.3-1.6-1.0-0.3-2.1-1.6-0.8-1.5-0.90.3-1.3-0.4-1.2-0.2-1.5-1.4
Locomotion distance, session 22.73.87.6-2.8-2.2-2.5-2.3-2.1-1.8-2.4-2.4-1.6-2.4-1.6-1.0-1.8-1.1-0.8-2.0-1.7-1.3
Locomotion velocity, session 30.50.51.6-0.9-0.8-0.8-0.9-0.9-1.3-0.7-0.8-0.6-0.7-0.5-0.7-0.4-0.4-0.6-0.9-0.20.0
Locomotion distance, session 30.50.51.5-0.00.90.10.60.70.80.0-0.31.0-0.50.91.10.80.91.2-0.00.31.0
Stereotopy head waving bouts, day 31.31.52.3-1.4-1.0-1.4-1.5-1.3-1.5-1.3-0.7-1.1-0.9-1.3-0.8-1.5-1.2-1.3-1.0-1.1-1.4
Stereotopy head waving duration, day 32.42.84.7-1.8-1.5-1.8-1.9-2.0-2.2-1.7-1.5-1.5-1.5-1.8-1.1-1.9-1.8-1.1-1.9-1.6-1.6
Locomotion velocity, session 70.20.21.9-0.40.5-0.30.10.10.1-0.3-0.60.2-0.50.31.40.20.70.30.2-0.40.1
Locomotion distance, session 70.40.61.7-1.3-0.6-1.0-0.9-0.8-0.8-0.9-1.1-0.4-1.2-0.4-0.1-0.4-0.0-0.2-0.7-0.6-0.1
Stereotopy head waving bouts, day 70.40.41.00.81.00.80.80.60.50.70.50.70.30.50.30.60.50.90.20.60.8
Stereotopy head waving duration, day 70.40.41.01.01.00.90.80.60.30.80.60.60.40.40.10.60.30.9-0.00.60.7
Locomotion velocity, session 83.33.97.0-2.6-2.1-2.6-2.2-1.9-1.2-2.4-2.0-1.8-2.2-2.1-0.8-2.2-1.5-1.2-1.4-2.3-2.0
Locomotion distance, session 87.310.514.9-3.5-3.5-3.5-3.7-3.8-3.9-3.3-3.1-3.4-3.1-3.3-2.4-3.3-3.0-2.2-3.3-3.0-2.7
Degree of sensitization distance4.64.76.7-2.2-2.4-2.2-2.5-2.5-2.6-2.0-1.6-2.5-1.5-2.4-1.7-2.4-2.1-2.1-1.5-2.0-2.3
Degree of sensitization stereotypy0.70.81.71.31.11.21.10.90.81.10.90.70.70.70.20.80.61.00.40.80.8
Conditioned locomotion0.20.31.90.1-0.70.2-0.4-0.4-1.00.3-0.1-0.20.1-0.3-1.40.1-0.1-0.4-0.30.60.4
Cocaine response after cond. corrected1.01.21.90.81.11.11.01.31.01.21.21.31.31.20.41.11.10.11.41.30.9
Cocaine response after cond. not corrected2.73.25.51.71.81.91.72.01.42.02.21.82.41.80.61.81.60.22.22.11.4
Cocaine response before conditioning0.30.30.70.70.60.60.60.40.00.70.70.30.80.70.50.70.4-0.00.60.50.5
Saline control response0.91.23.6-1.6-0.9-1.4-1.0-1.2-1.2-1.4-1.9-0.5-1.7-0.40.6-0.4-0.30.1-1.4-1.0-0.0
Bone: connectivity density0.30.41.7-0.6-0.9-0.4-0.8-0.5-1.1-0.2-0.0-0.4-0.1-0.6-1.1-0.4-0.4-1.3-0.20.0-0.3
Bone: cortical apparent density0.10.20.50.7-0.30.60.40.30.40.50.5-0.00.20.2-0.70.40.00.60.10.70.5
Bone: cortical area3.24.99.73.12.72.72.82.11.62.52.21.92.32.12.02.21.62.01.51.91.8
Bone: cortical porosity0.40.51.00.40.90.60.50.80.70.70.80.60.80.70.30.60.8-0.41.00.60.4
Bone: cortical porosity0.20.20.50.40.70.50.20.50.40.50.60.20.60.40.00.30.4-0.30.50.40.1
Bone: cortical thickness2.84.710.53.22.52.92.62.11.42.72.31.72.41.91.32.21.51.81.32.11.9
Bone: cortical thickness0.30.42.00.7-0.20.6-0.1-0.3-1.00.60.1-0.40.30.0-1.40.4-0.6-0.1-0.90.80.8
Bone: cortical tissue density0.20.20.50.7-0.20.60.40.30.50.50.50.10.30.2-0.60.40.10.70.10.70.6
Condit. Reinf. active minus inactive responses0.40.41.2-0.80.2-0.50.10.10.1-0.5-0.70.8-1.10.51.00.40.81.0-0.2-0.20.6
Condit. Reinf. active-inactive response ratio1.41.55.8-2.0-0.5-1.7-0.8-0.8-0.1-1.7-2.10.0-2.4-0.20.9-0.50.11.0-1.2-1.4-0.2
Condit. Reinf. active responses0.10.20.6-0.60.1-0.5-0.1-0.1-0.2-0.5-0.60.3-0.80.10.60.00.30.7-0.5-0.30.2
Condit. Reinf. inactive responses0.40.52.11.20.40.90.60.4-0.10.91.2-0.11.50.1-0.20.3-0.1-0.30.50.70.1
Incentive salience index mean0.60.82.10.10.90.30.80.80.60.2-0.11.2-0.31.21.41.01.31.40.30.41.2
Condit. Reinf. lever presses0.81.22.11.11.11.11.31.00.61.00.61.10.71.41.01.41.11.40.61.11.5
Condit. Reinf. active minus inactive responses0.60.81.9-0.7-0.6-0.9-0.8-1.2-1.4-1.0-0.9-0.9-0.9-0.60.1-0.7-0.9-0.5-1.3-1.1-0.5
Condit. Reinf. active-inactive response ratio0.10.10.8-0.20.0-0.10.1-0.1-0.3-0.1-0.30.3-0.40.60.30.60.40.4-0.30.20.9
Condit. Reinf. active responses1.72.34.0-1.8-1.4-1.9-1.6-1.9-2.0-1.9-1.8-1.4-1.9-1.10.0-1.1-1.0-0.8-1.8-1.7-0.7
Condit. Reinf. inactive responses2.22.94.0-1.9-1.6-2.0-1.8-1.9-1.8-2.0-1.8-1.7-1.9-1.7-0.4-1.7-1.4-1.0-1.7-2.0-1.5
Condit. Reinf. lever presses0.30.41.2-0.5-0.4-0.6-0.5-0.9-1.0-0.7-1.0-0.6-0.9-0.30.5-0.3-0.20.2-1.1-0.70.0
Condit. Reinf. lever reinforcers received1.11.63.3-1.6-1.0-1.5-1.3-1.6-1.8-1.5-1.7-1.0-1.7-0.70.3-0.7-0.6-0.4-1.7-1.3-0.3
Conditioned reinforcement - actives1.22.13.01.41.71.51.71.71.61.51.51.61.21.61.01.31.61.21.61.20.8
Conditioned reinforcement - inactives2.73.96.51.62.51.82.32.32.41.61.32.41.02.42.41.92.32.01.61.31.4
Conditioned locomotion1.52.03.21.51.61.51.51.71.81.51.61.51.61.20.91.11.20.51.71.20.6
Patch foraging indifference point 0 sec0.10.10.40.60.20.40.30.20.20.30.60.00.5-0.10.10.2-0.00.20.20.30.4
Patch foraging indifference point AUC0.71.03.0-1.5-0.6-1.3-0.8-1.0-0.5-1.4-1.7-0.3-1.7-0.31.1-0.4-0.2-0.0-0.9-1.3-0.2
Delay disc. indifference point, 0s delay7.78.511.53.02.83.33.03.02.63.32.73.32.43.20.63.43.22.52.43.23.2
Delay disc. indifference point, 16s delay4.34.78.71.62.11.82.22.22.21.81.72.41.42.51.62.82.51.82.42.43.0
Delay disc. indifference point, 2s delay7.38.111.03.03.13.23.03.12.43.12.73.22.43.21.43.32.82.12.23.03.0
Delay disc. indifference point, 24s delay4.95.512.41.72.22.12.22.52.02.21.72.51.62.80.83.22.61.82.13.03.5
Delay disc. indifference point, 4s delay5.25.57.92.22.62.42.52.62.12.31.92.62.02.81.92.82.51.81.92.42.6
Delay disc. indifference point, 8s delay1.51.83.51.21.51.21.61.11.31.00.51.60.71.61.71.61.31.90.61.01.6
Indifference point function ln k0.30.51.90.4-0.10.5-0.00.2-0.40.71.2-0.11.4-0.2-0.7-0.10.1-1.30.90.7-0.3
Indifference point function log k0.30.51.90.4-0.10.5-0.00.2-0.40.71.2-0.11.4-0.2-0.7-0.10.1-1.30.90.7-0.3
Patch foraging total patch changes 0 sec0.10.10.30.60.40.40.40.20.40.20.40.10.40.10.40.30.00.40.10.20.4
Patch foraging total patch changes 12 sec0.10.10.50.70.40.50.5-0.00.20.50.40.00.40.20.10.3-0.00.40.10.20.4
Patch foraging total patch changes 18 sec0.30.42.1-0.20.6-0.20.50.31.0-0.4-0.60.5-0.80.41.40.20.31.3-0.2-0.70.2
Patch foraging total patch changes 24 sec1.83.07.1-1.6-1.6-1.8-1.6-2.2-1.8-1.9-2.3-1.7-2.3-1.6-0.7-1.4-1.70.2-2.7-1.6-0.6
Patch foraging total patch changes 6 sec0.10.11.7-0.00.3-0.10.20.10.2-0.2-0.30.2-0.20.21.30.30.20.20.2-0.30.4
Patch foraging time to switch 0 sec0.30.64.61.2-0.10.80.20.20.20.70.7-0.70.5-0.8-2.1-0.6-0.80.6-0.50.2-0.7
Patch foraging water rate 0 sec0.40.98.90.21.30.10.90.40.6-0.0-0.20.90.31.03.00.70.60.60.6-0.20.5
Patch foraging water rate 12 sec0.20.43.2-0.30.6-0.30.1-0.3-0.4-0.5-0.50.2-0.60.21.8-0.3-0.10.2-0.6-1.1-0.6
Patch foraging water rate 18 sec0.50.82.70.5-0.50.0-0.6-0.8-1.6-0.00.4-1.20.9-1.1-0.6-0.8-1.5-1.6-0.8-0.3-0.9
Patch foraging water rate 24 sec0.60.83.5-0.10.5-0.60.0-0.3-0.4-0.8-0.7-0.7-0.5-0.31.8-1.0-0.90.2-0.8-1.9-1.6
Patch foraging water rate 6 sec0.20.42.50.40.80.10.3-0.0-0.3-0.10.1-0.20.10.01.6-0.5-0.5-0.1-0.4-1.1-1.0
Seeking ratio, delayed vs. immediate footshock0.50.62.1-1.4-1.2-1.2-0.9-0.70.4-1.1-0.6-0.3-0.5-0.10.3-0.3-0.1-1.30.3-0.4-0.4
Distance traveled before self-admin0.20.20.9-0.7-0.9-0.5-0.7-0.3-0.3-0.5-0.6-0.1-0.1-0.1-0.4-0.3-0.0-0.9-0.0-0.1-0.3
Distance traveled after self-admin0.10.10.40.2-0.20.4-0.10.30.20.40.30.50.50.5-0.50.40.5-0.40.30.60.3
Extensor digitorum longus weight2.811.017.34.04.23.83.93.62.83.53.63.33.43.33.03.22.72.33.02.72.5
Bone: elastic displacement0.30.30.90.5-0.50.2-0.2-0.3-0.50.10.5-0.60.3-1.0-0.9-0.7-0.9-0.7-0.3-0.3-0.7
Bone: elastic work0.50.73.01.70.61.20.70.4-0.21.11.6-0.11.4-0.4-0.4-0.2-0.8-0.40.20.3-0.4
Bone: endosteal estimation0.10.10.50.10.2-0.1-0.1-0.2-0.2-0.2-0.0-0.40.2-0.40.4-0.5-0.5-0.3-0.1-0.6-0.7
Bone: endosteal perimeter0.30.72.20.91.10.81.10.80.70.60.60.90.70.91.50.80.70.70.80.40.6
Epididymis fat weight1.13.98.12.82.02.72.32.01.22.62.31.62.31.40.41.81.61.52.02.11.6
Delta time in closed arm before/after self-admin2.32.25.5-1.3-2.2-1.2-1.8-2.0-2.2-0.8-0.6-1.5-0.9-1.3-2.3-1.0-1.3-1.8-0.8-0.5-0.6
Delta time in open arm before/after self-admin3.93.98.21.82.61.72.42.42.91.40.81.90.82.12.31.92.12.71.21.11.6
Diff in mean of infusions in LGA sessions0.10.20.7-0.4-0.6-0.2-0.3-0.2-0.0-0.2-0.80.0-0.5-0.0-0.70.10.20.3-0.50.30.5
Delay discount exponential model param8.39.314.2-2.8-3.2-3.1-3.3-3.1-2.7-2.9-2.4-3.4-2.2-3.5-2.2-3.8-3.2-2.8-2.5-3.2-3.8
Extinction: sum of active levers before priming1.21.34.20.20.60.60.81.01.10.70.31.50.61.50.61.71.50.91.41.62.1
Active lever presses in extinction session 61.01.02.30.90.61.20.81.11.01.31.31.21.20.9-0.50.81.30.01.51.10.3
Bone: final force0.30.41.91.41.10.90.90.30.40.60.30.10.60.20.70.2-0.31.2-0.40.00.1
Bone: final moment0.30.52.11.51.11.00.90.50.50.70.70.00.90.10.60.1-0.20.8-0.10.1-0.1
Food consumed during 24 hour testing period0.40.53.0-0.80.2-0.9-0.0-0.30.2-1.0-1.1-0.3-1.0-0.11.70.1-0.00.5-0.1-0.80.5
Glucose6.810.737.60.03.90.63.23.94.90.3-0.34.0-0.43.96.12.94.14.52.80.52.4
Heart weight0.40.71.30.51.00.61.00.81.00.60.20.80.51.01.11.00.80.90.90.60.8
Delay discount hyperbolic model param8.79.714.4-3.0-3.3-3.2-3.4-3.2-2.8-3.0-2.4-3.5-2.3-3.6-2.2-3.8-3.2-2.9-2.5-3.2-3.7
Intermittent access intake day 1-15 change0.40.72.00.21.10.40.90.91.40.40.01.10.11.11.30.31.11.10.9-0.1-0.4
Intermittent access intake escalation0.51.12.10.41.30.71.11.11.50.70.51.40.51.41.40.81.41.01.30.40.1
Intermittent access intake escalation 20.20.31.10.40.70.30.50.61.10.30.30.40.50.40.7-0.10.30.40.5-0.2-0.7
Intermitt. access day 1 inactive lever presses0.10.61.20.40.70.60.70.60.00.70.31.00.21.11.11.01.00.30.80.70.9
Intermitt. access day 15 inactive lever presses1.02.110.00.41.60.41.51.01.20.2-0.81.4-0.51.83.21.71.42.20.30.22.0
Intermitt. access escalation Index0.50.72.0-1.0-0.6-1.0-0.7-1.0-1.2-1.0-1.2-0.6-1.4-0.7-0.2-0.2-0.70.6-1.0-0.40.6
Intermittent access day 1 total infusions1.42.34.11.71.31.81.61.82.01.71.71.61.41.50.31.51.61.11.21.51.1
Intermittent access day 15 total infusions2.53.87.21.72.41.92.22.32.71.81.72.31.52.31.61.72.31.62.01.20.8
Intermittent access terminal intake (last 3 days)1.62.24.91.41.81.51.61.82.21.41.51.81.21.71.31.01.61.11.60.70.1
Intermittent access total infusions2.22.75.01.51.91.61.72.12.21.61.92.01.41.81.21.21.90.91.91.00.3
Intermittent access day 1 locomotion0.10.10.3-0.4-0.5-0.3-0.5-0.10.2-0.3-0.2-0.1-0.2-0.3-0.4-0.3-0.1-0.6-0.2-0.0-0.3
Intermittent access day 15 total locomotion2.44.36.72.32.32.32.52.32.62.21.72.21.72.11.52.12.02.01.81.71.7
Intermittent access total locomotion1.61.93.31.01.61.21.41.71.71.21.21.80.91.61.51.41.70.81.61.01.0
Intermittent access standard deviation0.10.10.50.40.50.30.30.40.50.20.10.40.10.30.7-0.10.30.3-0.2-0.2-0.6
Left kidney weight0.41.87.42.71.52.21.40.6-0.22.12.00.52.20.20.20.6-0.0-0.00.80.90.2
Right kidney weight0.73.111.03.31.32.81.50.8-0.52.82.80.72.90.4-1.01.00.2-0.31.02.10.8
Cocaine induced anxiety1.21.74.80.71.50.81.41.31.50.70.31.40.81.62.21.61.51.11.21.01.5
Post-drug Anxiety2.32.54.31.11.51.31.61.61.91.30.81.81.21.91.42.01.81.61.51.72.1
Baseline Anxiety0.30.31.80.50.10.60.30.50.40.70.60.40.40.3-1.30.30.50.60.40.80.2
Tail length0.93.57.12.72.32.42.22.31.62.12.51.62.61.31.51.31.10.31.81.20.6
Length with tail1.56.613.83.73.23.33.02.91.83.13.32.13.42.01.82.11.60.92.62.01.3
Length without tail1.34.07.12.62.22.52.22.11.32.52.71.72.41.60.71.91.60.82.42.11.5
LgA early post infusion interval1.72.34.01.91.21.91.61.71.42.01.91.42.01.60.31.01.70.72.01.1-0.0
LgA late post infusion interval0.20.31.0-0.50.1-0.20.20.60.9-0.1-0.00.5-0.10.60.50.31.00.50.90.10.2
LgA early loading0.30.62.2-0.6-0.9-0.4-0.8-1.0-1.5-0.1-0.5-0.7-0.0-0.6-1.10.1-0.6-1.1-0.20.70.7
LgA late loading0.20.41.20.90.20.90.30.4-0.11.01.00.21.10.2-0.80.5-0.0-0.60.51.10.4
LgA early average infusions0.81.02.4-1.3-1.0-1.2-1.1-1.3-1.6-1.0-1.3-1.0-1.1-1.0-0.8-0.3-1.0-0.6-1.00.10.7
LgA late average infusions0.40.51.2-0.5-0.8-0.6-0.6-0.9-0.8-0.7-0.8-0.7-0.9-0.7-0.8-0.4-1.0-0.1-1.1-0.40.1
LgA early timeout1.71.84.6-2.0-0.9-1.8-1.3-1.5-1.0-1.8-2.1-1.0-2.0-1.10.1-0.8-1.0-0.1-1.6-1.10.0
LgA late timeout0.91.12.7-0.5-0.9-0.8-1.0-1.5-1.3-0.9-0.5-1.3-0.5-1.4-0.6-1.1-1.6-0.9-1.3-1.0-0.8
LgA early titration0.40.62.3-0.9-0.5-0.8-0.5-0.6-1.2-0.7-1.2-0.4-0.9-0.3-0.20.4-0.40.0-0.70.61.5
LgA late titration0.10.21.50.00.1-0.00.1-0.2-0.1-0.1-0.60.1-0.50.0-0.10.5-0.20.8-0.60.31.2
LgA total infusion0.50.71.2-0.9-0.9-0.9-0.8-1.1-1.0-0.8-1.1-0.6-1.1-0.7-0.7-0.1-0.8-0.1-1.00.00.7
Times rat made contact with spout1.21.44.0-2.0-0.9-1.9-0.9-0.90.2-1.9-2.0-0.6-1.9-0.41.1-0.3-0.10.2-0.6-1.10.5
Lifetime Intake1.92.34.31.31.61.51.62.02.11.51.81.81.51.71.11.11.80.61.90.90.2
Liver weight, left0.10.21.20.3-0.40.3-0.3-0.6-1.10.30.4-0.30.5-0.4-0.5-0.2-0.4-0.9-0.10.1-0.2
Liver weight, right0.30.51.50.4-0.4-0.0-0.4-0.9-1.2-0.1-0.5-0.90.0-0.9-0.5-0.7-1.0-0.2-1.2-0.5-0.6
Locomotor activity0.30.52.9-0.60.7-0.60.20.71.1-0.7-0.30.2-0.70.31.7-0.40.30.40.2-1.2-1.0
Locomotor testing distance0.61.12.21.31.41.21.21.21.11.11.50.91.20.91.00.50.90.41.00.5-0.1
Locomotor testing rearing1.02.14.11.21.81.21.61.81.91.11.31.61.31.52.01.11.50.91.50.90.6
Locomotion in novel chamber0.20.31.3-0.1-0.4-0.1-0.6-0.6-0.90.0-0.1-0.50.1-0.5-1.1-0.1-0.5-0.8-0.40.30.2
Locomotion in novel chamber post-restriction1.42.35.0-2.2-1.6-2.0-1.7-1.8-1.3-1.9-2.2-1.2-2.1-1.1-0.6-1.2-0.9-0.2-1.6-1.1-0.6
Fecal boli incidents, locomotor time 10.30.51.3-1.1-0.4-1.0-0.9-0.7-0.7-0.9-0.7-0.5-0.7-0.50.3-0.7-0.4-0.9-0.2-0.9-0.7
Change in fecal boli incidents, locomotor task1.01.02.9-1.4-0.8-1.4-0.8-0.8-0.1-1.4-1.7-0.7-1.4-0.70.2-0.8-0.60.1-1.0-1.2-0.5
Time >=10cm from walls, locomotor time 10.30.32.00.6-0.20.40.1-0.2-0.00.5-0.1-0.50.3-0.6-1.4-0.7-0.20.7-0.40.2-0.9
Bouts of movement, locomotor time 10.20.21.0-0.10.50.10.30.40.30.1-0.00.5-0.30.3-0.10.60.51.00.20.51.0
Total resting periods, locomotor time 10.30.41.7-0.20.60.00.40.60.40.1-0.30.7-0.70.50.30.70.71.30.10.51.2
Rest time, locomotor task time 10.30.31.1-0.70.3-0.7-0.2-0.0-0.1-0.8-0.9-0.0-1.0-0.01.00.3-0.10.4-0.5-0.01.0
Distance moved, locomotor task time 10.20.31.30.7-0.20.40.0-0.30.10.30.7-0.50.6-0.3-1.0-0.6-0.6-0.5-0.0-0.4-1.2
Vertical activity count, locomotor time 10.30.72.4-0.5-1.2-0.5-0.8-0.7-0.1-0.5-0.2-0.9-0.1-0.6-1.3-1.1-0.8-1.0-0.2-0.9-1.5
Time >=10cm from walls, locomotor time 20.20.30.6-0.6-0.8-0.6-0.6-0.8-0.3-0.5-0.5-0.6-0.1-0.4-0.7-0.6-0.4-0.2-0.3-0.2-0.7
Bouts of movement, locomotor time 20.20.30.70.40.40.60.60.2-0.10.60.40.9-0.00.70.60.60.80.60.30.40.4
Total resting periods, locomotor time 20.20.41.00.30.40.50.60.2-0.10.50.21.0-0.30.90.90.80.90.90.20.40.8
Rest time, locomotor task time 20.40.61.3-0.9-0.4-1.0-0.7-0.7-0.8-1.0-1.0-0.7-1.1-0.60.1-0.5-0.6-0.0-1.0-0.70.0
Distance moved, locomotor task time 20.10.21.10.3-0.20.2-0.1-0.40.00.20.4-0.30.5-0.4-1.0-0.3-0.6-0.30.00.0-0.4
Vertical activity count, locomotor time 20.10.10.7-0.0-0.20.2-0.10.10.30.30.40.20.50.2-0.80.20.1-0.70.70.40.0
Light reinforcement 10.40.92.21.51.41.31.20.80.11.21.20.91.30.60.80.70.20.80.20.80.5
Light reinforcement 20.20.31.31.10.50.70.4-0.1-0.30.40.7-0.30.5-0.40.0-0.4-0.70.2-0.5-0.3-0.6
Bone: marrow area0.00.10.40.00.1-0.2-0.1-0.3-0.3-0.2-0.1-0.40.1-0.30.3-0.5-0.5-0.2-0.1-0.6-0.6
Bone: maximum diameter2.85.29.92.52.92.33.02.32.32.01.72.21.82.43.12.21.92.61.81.41.7
Bone: maximum force0.20.31.81.30.70.80.70.20.00.60.6-0.10.6-0.10.4-0.0-0.50.7-0.4-0.1-0.1
Bone: maximum moment0.20.41.91.40.80.90.70.30.10.70.9-0.20.9-0.10.4-0.1-0.50.2-0.0-0.0-0.3
Mean time between licks in bursts0.41.13.4-1.8-0.7-1.7-1.0-0.7-0.3-1.7-1.5-0.5-1.4-0.80.6-0.5-0.8-0.6-0.6-0.90.0
Mean num. licks in bursts2.13.38.9-2.9-1.6-2.5-1.7-1.6-1.1-2.5-3.0-0.8-2.8-0.60.8-1.2-0.30.1-1.6-2.0-1.1
Cd content in liver0.10.10.5-0.00.50.00.40.50.6-0.1-0.10.4-0.10.20.40.10.00.70.0-0.20.0
Co content in liver0.80.91.70.91.31.01.01.00.41.00.81.10.81.00.91.11.20.51.00.91.0
Cu content in liver0.20.20.7-0.10.00.20.10.3-0.20.40.40.60.40.5-0.40.60.6-0.00.70.90.7
Fe content in liver1.01.23.8-1.9-0.9-1.5-1.4-1.1-1.1-1.3-1.6-0.5-1.7-0.5-0.4-0.5-0.1-0.5-0.9-0.6-0.1
K content in liver5.35.19.22.21.82.52.02.41.22.72.82.32.72.10.22.52.40.42.73.02.3
Mg content in liver4.84.96.72.32.22.52.32.31.52.62.42.22.42.20.92.42.21.22.52.62.2
Mn content in liver0.10.20.60.10.10.20.10.50.20.30.50.40.60.40.00.30.6-0.60.80.40.1
Na content in liver4.54.88.91.02.21.62.12.42.41.71.12.81.22.82.02.73.01.82.32.42.6
Rb content in liver0.70.81.31.11.11.11.01.00.61.01.10.90.60.90.31.10.80.80.90.91.0
Se content in liver3.13.76.91.91.52.11.82.11.02.22.41.92.51.90.62.11.90.12.62.21.7
Sr content in liver1.61.43.11.21.61.01.61.31.70.80.71.20.71.21.81.01.01.61.00.40.6
Zn content in liver0.20.21.10.70.30.60.50.4-0.10.60.80.21.1-0.00.3-0.0-0.1-0.40.50.2-0.4
Bone: minimum diameter0.10.10.40.40.10.10.0-0.3-0.60.10.2-0.40.2-0.30.3-0.4-0.5-0.3-0.2-0.5-0.6
Time in familiar zone, hab. session 11.71.62.6-1.0-1.1-1.2-1.3-1.3-0.7-1.3-1.2-1.4-1.4-1.5-1.0-1.6-1.4-0.5-1.6-1.5-1.4
Time in novel zone, hab. session 11.21.22.51.10.81.21.11.10.71.21.41.01.61.10.71.10.9-0.11.51.20.8
Total zone transitions, hab. session 10.91.32.8-1.6-0.9-1.5-1.1-1.0-0.5-1.6-1.7-0.7-1.7-0.80.1-1.0-0.6-0.0-1.5-1.3-0.7
Total locomotion distance, hab. session 10.20.21.1-1.0-0.4-0.8-0.5-0.10.0-0.7-0.60.1-0.7-0.00.4-0.20.2-0.2-0.2-0.4-0.1
Locomotion velocity, hab. session 10.20.31.4-1.2-0.3-0.9-0.5-0.2-0.2-0.8-0.80.1-0.9-0.00.4-0.20.20.1-0.5-0.4-0.1
Time in familiar zone, hab. session 22.93.05.8-1.5-2.3-1.6-2.0-2.0-1.7-1.4-1.5-2.0-1.3-1.9-2.4-1.8-1.9-1.4-1.7-1.2-1.4
Time in novel zone, hab. session 22.22.26.21.72.11.41.91.61.41.21.31.41.11.42.51.21.21.51.20.60.8
Total zone transitions, hab. session 20.20.31.2-0.40.3-0.40.10.10.0-0.5-0.70.5-0.70.21.1-0.00.20.9-0.6-0.5-0.0
Total locomotion distance, hab. session 20.30.32.3-0.20.6-0.20.50.40.6-0.4-0.40.6-0.50.31.50.10.41.1-0.1-0.5-0.1
Locomotion velocity, hab. session 20.30.52.30.00.90.10.70.70.8-0.0-0.10.9-0.20.71.50.50.71.20.2-0.00.3
Novel to familiar place preference ratio1.61.73.70.11.20.51.21.21.50.40.01.7-0.21.81.91.71.91.80.70.81.8
Novelty place preference1.51.63.70.21.20.51.21.21.40.40.11.6-0.11.81.91.61.81.70.80.81.7
Time in novel zone, NPP test1.31.43.70.11.10.41.11.01.30.3-0.01.5-0.21.71.91.51.61.60.70.61.6
Total zone transitions, NPP test0.10.10.8-0.1-0.20.0-0.2-0.1-0.90.10.30.00.0-0.0-0.40.20.1-0.3-0.20.40.3
Total locomotion distance, NPP test0.10.10.4-0.00.00.10.10.3-0.20.20.40.40.10.3-0.00.50.70.00.30.60.6
Locomotion velocity, NPP test0.20.31.00.10.30.40.30.60.10.50.70.70.30.6-0.10.81.00.10.61.00.9
Intraocular pressure0.71.13.3-0.60.4-0.80.0-0.30.6-1.1-1.8-0.1-1.8-0.41.5-0.7-0.01.7-1.3-1.5-0.5
Delta distance traveled before/after self-admin0.40.50.80.90.70.90.70.80.70.90.90.60.60.6-0.30.60.60.60.30.80.5
Delta ambulatory time before/after self-admin0.10.10.70.20.00.30.00.30.10.40.50.10.40.1-0.90.20.2-0.10.20.70.3
Parametrial fat weight1.43.214.1-0.81.6-0.51.21.22.3-0.9-1.91.9-2.21.63.21.11.83.8-0.2-0.71.5
Pavlov. Cond. lever latency0.10.10.3-0.30.3-0.10.00.30.4-0.00.10.40.30.20.20.10.1-0.40.50.1-0.1
Pavlov. Cond. magazine entry latency1.41.92.9-1.5-1.7-1.5-1.5-1.5-1.2-1.6-1.4-1.4-1.7-1.1-0.7-1.2-1.2-0.7-1.6-1.5-1.0
Pavlov. Cond. change in total contacts0.50.61.70.20.50.30.70.81.20.2-0.10.9-0.30.90.90.81.11.30.20.41.0
Pavlov. Cond. index score0.70.92.0-0.9-1.4-1.0-1.1-1.1-1.1-1.0-1.0-1.0-1.2-0.8-0.9-0.7-0.7-0.4-1.3-0.8-0.4
Pavlov. Cond. latency score0.70.91.8-0.7-1.3-0.8-1.0-1.1-1.0-0.9-0.9-1.1-1.1-0.8-0.9-0.8-0.8-0.3-1.3-0.8-0.5
Pavlov. Cond. lever contacts0.20.30.8-0.2-0.7-0.3-0.4-0.7-0.7-0.3-0.5-0.6-0.6-0.5-0.5-0.4-0.30.1-0.9-0.4-0.2
Pavlov. Cond. magazine entry number1.31.64.01.81.51.61.41.31.01.61.71.02.00.70.30.90.70.41.51.30.6
Pavlov. Cond. intertrial magazine entries1.21.43.31.41.01.50.91.0-0.11.71.80.71.80.9-0.01.20.9-0.51.51.61.0
Pavlov. Cond. lever-magazine prob. diff.0.81.02.1-0.9-1.4-0.9-1.1-1.2-1.2-0.9-0.9-1.1-1.1-0.8-1.0-0.8-0.8-0.5-1.2-0.7-0.5
Pavlov. Cond. response bias0.10.20.5-0.6-0.7-0.5-0.5-0.4-0.5-0.4-0.4-0.3-0.7-0.1-0.3-0.10.0-0.2-0.4-0.30.0
Pavlov. Cond. lever latency2.53.57.92.41.82.41.82.21.52.42.81.72.61.2-0.31.40.90.12.02.11.0
Pavlov. Cond. magazine entry latency0.10.10.40.30.30.20.2-0.10.10.0-0.2-0.0-0.20.40.40.30.10.6-0.4-0.00.5
Pavlov. Cond. change in total contacts0.71.23.0-1.1-0.9-1.2-0.9-1.3-0.9-1.4-1.7-1.0-1.7-0.60.4-0.6-0.50.3-1.5-1.2-0.3
Pavlov. Cond. index score0.91.22.9-1.2-1.0-1.3-1.0-1.4-1.0-1.4-1.7-1.0-1.7-0.60.3-0.7-0.60.2-1.5-1.3-0.4
Pavlov. Cond. latency score1.01.32.9-1.2-1.1-1.3-1.1-1.5-1.1-1.4-1.7-1.2-1.6-0.60.1-0.8-0.70.0-1.5-1.3-0.4
Pavlov. Cond. lever contacts2.43.36.9-2.4-1.9-2.3-1.9-2.2-1.6-2.3-2.6-1.6-2.6-1.10.1-1.3-0.9-0.3-1.9-1.9-0.9
Pavlov. Cond. magazine entry number0.10.20.5-0.00.00.30.00.50.00.50.50.50.50.1-0.40.20.5-0.60.70.60.1
Pavlov. Cond. intertrial magazine entries0.10.10.5-0.4-0.2-0.1-0.20.1-0.40.10.40.10.4-0.1-0.1-0.10.4-0.70.70.3-0.2
Pavlov. Cond. lever-magazine prob. diff.1.01.32.7-1.2-1.1-1.3-1.1-1.5-1.0-1.4-1.7-1.2-1.7-0.70.1-0.8-0.70.1-1.6-1.3-0.5
Pavlov. Cond. response bias1.21.63.5-1.6-1.2-1.6-1.2-1.6-0.9-1.6-1.9-1.2-1.9-0.80.1-0.9-0.60.1-1.4-1.4-0.5
LgA PC1 addiction-like behavior0.10.31.2-0.4-0.3-0.4-0.3-0.6-1.1-0.4-0.5-0.4-0.4-0.4-0.20.2-0.6-0.2-0.50.50.9
Time in closed arm before self-admin0.40.51.70.4-0.2-0.0-0.4-0.7-1.0-0.10.1-1.00.6-1.1-0.6-0.7-1.3-0.9-0.7-0.3-0.5
Time in closed arm after self-admin1.71.85.5-0.5-1.5-0.7-1.4-1.8-2.3-0.4-0.0-1.70.1-1.7-2.0-1.1-1.8-2.0-0.8-0.3-0.6
Time in open arm before self-admin0.00.00.3-0.0-0.30.0-0.00.10.10.10.50.10.00.1-0.2-0.2-0.1-0.20.1-0.2-0.6
Time in open arm after self-admin1.11.24.50.51.30.51.21.21.80.3-0.21.1-0.41.31.80.71.22.10.2-0.20.3
Bone: periosteal estimation0.51.13.11.81.51.41.40.90.61.21.20.71.30.81.30.80.40.90.60.60.5
Bone: periosteal perimeter2.13.75.72.42.42.22.41.91.42.01.61.91.72.02.12.01.61.91.41.61.8
Bone: post-yield work0.10.20.4-0.4-0.4-0.4-0.4-0.20.2-0.40.1-0.5-0.2-0.3-0.1-0.5-0.3-0.60.2-0.6-0.6
Progressive ratio test 1 active lever presses1.82.24.00.81.31.21.31.71.61.31.41.91.21.91.01.72.00.61.91.61.4
Progressive ratio test 1 breakpoint1.92.34.20.81.31.31.41.71.61.41.52.01.32.01.01.82.00.61.91.61.5
Progressive ratio test 1 inactive lever presses2.73.96.51.32.21.62.12.12.51.41.12.51.02.52.42.32.41.81.81.42.1
Progressive ratio test 2 active lever presses1.51.85.21.21.51.31.51.72.31.21.21.50.91.41.01.11.51.31.30.80.6
Progressive ratio test 2 breakpoint1.41.64.71.11.41.21.41.62.21.11.11.40.81.30.91.01.41.31.20.70.5
Progressive ratio test 2 inactive lever presses2.74.48.82.02.71.92.62.23.01.61.22.30.92.22.42.02.03.01.21.21.7
ShA PR total presses0.70.93.6-0.3-1.1-0.4-0.9-1.2-1.9-0.1-0.2-1.20.1-1.0-1.6-0.4-1.1-1.2-0.50.30.1
Incentive Sensitization - Responses0.60.93.61.21.21.01.21.11.90.70.70.70.10.60.50.50.61.70.30.20.4
Incentive Sensitization - Breakpoint0.60.83.31.21.10.91.11.01.80.70.60.60.10.40.50.40.41.70.10.00.2
LgA PR total presses0.20.21.00.2-0.30.1-0.0-0.4-0.60.30.3-0.20.4-0.2-1.00.3-0.4-0.00.10.80.7
Sum of active levers in priming session hrs 5-61.21.12.31.0-0.01.20.91.00.91.31.21.21.31.1-0.51.11.10.31.41.50.8
Progressive ratio0.10.10.60.50.50.30.20.50.70.20.5-0.10.2-0.1-0.3-0.20.10.10.1-0.2-0.3
Food seeking constrained by brief footshock3.03.66.42.41.62.32.02.32.52.11.91.51.91.80.52.21.70.91.61.92.2
Seeking ratio, punishment vs. effort0.50.81.60.80.60.90.90.70.30.90.61.00.81.21.01.30.80.30.71.01.3
Retroperitoneal fat weight0.52.012.60.11.50.21.20.91.2-0.2-1.61.6-1.41.12.30.91.23.5-0.7-0.31.3
Reaction time number correct0.71.33.2-1.1-0.5-1.4-0.8-0.8-0.5-1.5-1.0-1.0-1.0-1.21.1-1.4-1.1-0.6-1.0-1.8-1.6
Reaction time mean minus median0.00.10.4-0.3-0.2-0.20.00.10.4-0.10.0-0.00.20.1-0.10.30.20.10.60.10.4
Reaction time mean minus median AUC0.20.50.70.80.70.70.80.70.70.70.80.60.70.70.30.70.60.80.70.60.6
Reaction time num false alarms1.11.52.81.71.21.71.31.00.91.61.21.11.01.30.01.41.31.30.61.31.2
Reaction time num false alarms AUC0.91.43.71.91.21.81.30.90.71.71.40.81.11.0-0.41.11.01.10.41.20.9
Reaction time trials correct on left0.71.33.2-1.1-0.5-1.4-0.8-0.8-0.5-1.5-1.0-1.0-1.0-1.21.1-1.4-1.1-0.6-1.0-1.8-1.6
Reaction time trials on left0.71.33.2-1.2-0.5-1.4-0.9-0.8-0.6-1.5-1.0-1.1-1.0-1.21.1-1.5-1.1-0.6-1.0-1.8-1.6
Reaction time mean0.10.21.20.0-0.40.1-0.10.30.30.30.4-0.20.5-0.0-1.1-0.00.0-0.30.60.4-0.2
Reaction time mean AUC0.10.21.30.1-0.40.2-0.10.20.10.30.5-0.30.5-0.1-1.1-0.1-0.0-0.40.50.3-0.4
Median of all reaction times0.10.21.90.0-0.50.1-0.20.20.10.30.4-0.40.5-0.2-1.4-0.2-0.1-0.50.40.4-0.4
Reaction time omissions0.10.10.4-0.7-0.3-0.5-0.5-0.1-0.4-0.5-0.2-0.1-0.7-0.3-0.1-0.3-0.0-0.1-0.4-0.2-0.2
Reaction time false alarm rate2.23.06.22.51.42.51.71.41.02.42.01.31.71.6-0.91.81.51.31.02.21.7
Reaction time premature initiation rate2.43.37.5-1.4-1.9-1.5-1.9-2.6-2.7-1.4-1.7-1.9-1.4-1.8-1.6-1.6-2.1-1.3-2.3-1.4-1.1
Reaction time premature initiations2.23.96.7-1.7-1.8-1.9-2.0-2.6-2.5-2.0-2.0-2.1-1.7-2.0-0.7-2.0-2.2-1.3-2.4-2.1-1.8
Std. dev. reaction times0.00.10.50.00.00.00.20.30.70.10.00.00.10.1-0.20.10.20.60.30.10.1
Reaction time trials completed0.71.33.2-1.2-0.5-1.4-0.9-0.8-0.6-1.5-1.0-1.1-1.0-1.21.1-1.5-1.1-0.6-1.0-1.8-1.6
Reaction time trials AUC0.61.12.7-1.0-0.5-1.3-0.8-0.7-0.5-1.4-0.8-1.0-0.8-1.11.1-1.4-1.0-0.7-0.8-1.6-1.5
Run reversals in cocaine runway, females0.20.22.4-0.3-0.4-0.1-0.5-0.2-0.3-0.1-0.5-0.3-0.4-0.3-1.5-0.2-0.10.4-0.70.1-0.0
Run reversals in cocaine runway, males0.00.00.20.1-0.40.10.1-0.1-0.2-0.00.00.10.10.10.10.2-0.10.1-0.10.20.5
Latency to leave start box in cocaine runway0.20.20.60.00.50.30.20.5-0.10.2-0.30.6-0.00.70.40.70.70.20.10.30.7
Latency to leave start box in cocaine runway, F0.60.61.61.21.01.11.00.70.31.00.20.80.60.90.50.90.70.90.00.60.7
Latency to leave start box in cocaine runway, M0.40.31.6-1.3-0.1-0.8-0.60.1-0.3-0.6-0.80.3-0.60.40.50.50.6-0.50.2-0.10.7
Std. dev. time between licks in bursts0.91.32.3-1.5-1.2-1.5-1.4-1.2-1.0-1.4-1.4-1.1-1.2-1.1-0.6-0.7-1.1-1.0-1.2-0.7-0.0
Total sessions with >9 infusions0.10.10.3-0.2-0.3-0.1-0.2-0.2-0.5-0.1-0.10.1-0.30.20.3-0.10.1-0.4-0.2-0.3-0.3
Short access day 1 total inactive lever presses1.62.14.71.32.01.31.71.81.71.11.21.50.81.62.21.41.61.11.10.41.1
Short access day 10 total inactive lever presses0.10.22.20.20.70.20.40.2-0.50.10.00.5-0.10.41.50.30.2-0.1-0.0-0.40.1
Short access day 1 total infusions0.10.10.50.30.10.30.00.3-0.40.30.50.10.40.1-0.1-0.20.2-0.40.0-0.1-0.7
Short access day 10 total infusions0.10.10.3-0.3-0.4-0.2-0.3-0.00.1-0.3-0.0-0.1-0.3-0.1-0.0-0.30.0-0.3-0.3-0.5-0.6
Short access total infusions0.10.20.40.30.30.40.30.70.50.30.70.50.40.50.40.00.6-0.20.4-0.0-0.5
ShA early post infusion interval0.20.21.50.20.20.10.40.30.1-0.0-0.00.50.20.61.20.50.30.3-0.0-0.10.4
ShA late post infusion interval0.30.31.1-0.6-0.3-0.5-0.30.00.7-0.7-0.8-0.1-1.0-0.10.2-0.10.20.6-0.6-0.80.2
ShA early loading0.80.81.3-1.0-0.9-1.0-1.1-1.1-1.1-1.0-1.0-1.1-0.9-0.9-0.5-0.8-0.7-0.7-0.6-0.6-0.6
ShA late loading1.52.03.8-1.6-1.5-1.6-1.6-1.9-1.9-1.3-1.5-1.7-1.1-1.5-1.1-1.1-1.4-1.2-1.1-0.7-0.5
Short access day 1 locomotion0.70.81.7-0.4-1.0-0.6-0.9-1.0-1.3-0.7-0.2-0.9-0.5-1.1-0.6-1.1-1.1-1.3-0.9-1.0-1.1
Short access day 10 total locomotion1.73.15.3-2.3-2.1-2.1-2.3-1.7-1.7-2.1-1.4-1.4-1.9-1.7-0.8-1.6-1.4-2.2-1.5-1.5-1.1
Short access total locomotion2.53.04.3-1.9-1.8-1.9-2.1-1.9-2.0-2.0-1.5-1.3-1.9-1.7-0.4-1.7-1.6-2.0-1.7-1.8-1.4
ShA early average infusions1.72.05.6-2.4-1.7-2.0-1.8-1.4-1.1-1.8-2.1-1.3-1.6-1.2-0.5-1.1-0.6-1.1-0.5-0.9-0.6
ShA late average infusions0.60.63.5-0.3-0.6-0.2-0.7-0.8-1.90.10.1-0.70.4-0.5-1.4-0.1-0.4-1.40.00.80.2
ShA early timeout0.91.02.9-1.6-0.9-1.5-1.1-0.90.0-1.4-1.7-0.9-1.4-0.8-0.1-0.7-0.3-0.2-0.4-0.7-0.3
ShA late timeout0.30.31.00.50.40.60.2-0.1-1.00.80.8-0.00.90.1-0.60.30.1-0.60.70.80.2
ShA early titration2.22.57.4-2.7-1.9-2.3-2.0-1.5-1.3-2.0-2.2-1.3-2.0-1.1-0.6-1.0-0.6-1.3-0.7-1.0-0.5
ShA late titration0.70.74.6-0.5-0.7-0.4-0.9-1.1-2.1-0.1-0.3-1.0-0.1-0.8-1.3-0.4-0.9-1.1-0.50.3-0.0
ShA total infusions1.11.44.6-1.3-1.2-1.2-1.4-1.4-2.1-0.9-1.1-1.4-0.8-1.1-1.3-0.9-1.0-1.2-0.9-0.3-0.5
One hour access (0.3 mA shock)0.91.03.70.61.00.81.01.41.90.80.91.20.71.10.90.51.30.71.40.3-0.3
Shock compulsivity0.20.42.80.2-0.90.2-0.4-0.5-1.00.30.3-0.50.3-0.5-1.7-0.3-0.6-0.9-0.10.3-0.3
Compulsive drug intake1.92.34.9-1.6-2.1-1.4-2.0-1.7-2.1-1.1-1.2-1.6-1.0-1.5-2.2-1.1-1.2-1.9-0.9-0.5-0.5
One hour access (shock baseline)2.64.09.11.52.41.72.22.63.01.62.02.41.52.22.01.52.31.52.31.10.5
Social response proportion0.30.41.1-0.9-0.1-1.0-0.30.00.5-1.1-0.7-0.2-0.8-0.70.7-0.5-0.50.3-0.3-0.5-0.1
Social responses0.20.31.6-0.60.3-0.70.10.30.8-0.8-0.7-0.0-0.8-0.31.3-0.2-0.10.60.0-0.60.0
Social time0.70.92.2-1.2-1.1-1.3-1.1-0.7-0.3-1.2-1.0-1.1-0.8-1.5-0.8-1.0-1.0-0.6-0.8-0.5-0.4
Soleus weight0.82.37.12.72.02.11.81.41.01.82.40.72.30.71.30.60.20.11.30.8-0.1
Bone: stiffness0.10.10.40.20.30.20.1-0.2-0.50.2-0.4-0.1-0.10.20.20.30.20.6-0.50.20.5
Tibialis anterior weight1.55.08.12.62.82.42.72.52.32.22.22.21.92.42.12.31.91.82.01.71.9
Time to tail flick, vehicle, before self-admin0.20.20.80.90.60.70.40.20.80.50.4-0.00.3-0.3-0.5-0.2-0.10.7-0.2-0.1-0.3
Time to tail flick, vehicle, after self-admin0.10.21.0-0.7-0.1-0.4-0.5-0.0-0.1-0.3-0.30.2-1.00.1-0.4-0.00.40.0-0.3-0.30.1
Time to tail flick, test, before self-admin0.20.20.7-0.4-0.1-0.4-0.4-0.5-0.9-0.4-0.3-0.4-0.0-0.40.4-0.4-0.3-0.7-0.4-0.7-0.5
Time to tail flick, test, after self-admin1.11.23.91.21.61.01.31.21.00.81.00.90.91.02.01.00.80.40.90.40.8
Delta time to tail flick, vehicle, before/after SA0.50.52.2-1.5-0.7-1.0-0.8-0.3-0.7-0.9-0.90.1-1.20.10.0-0.00.3-0.4-0.3-0.30.2
Delta time to tail flick, test, before/after SA0.50.51.20.60.90.50.90.91.10.40.50.60.30.81.00.80.60.70.80.50.7
Tibia length0.30.72.31.3-0.21.00.0-0.2-0.91.01.4-0.71.1-0.6-1.5-0.2-0.9-0.8-0.10.5-0.3
Ambulatory time before self-admin0.10.10.5-0.3-0.6-0.1-0.4-0.00.1-0.1-0.20.10.20.1-0.4-0.10.3-0.70.30.2-0.3
Ambulatory time after self-admin0.20.21.0-0.4-0.6-0.0-0.50.0-0.20.00.10.10.10.1-1.00.00.4-0.90.40.4-0.1
Bone: tissue strength0.90.93.8-0.1-0.4-0.6-0.6-0.7-0.3-0.7-0.1-1.2-0.1-1.5-0.0-1.6-1.2-0.8-0.5-1.5-1.9
Total heroin consumption0.30.30.7-0.2-0.9-0.3-0.5-0.7-0.9-0.2-0.2-0.50.2-0.7-0.6-0.7-0.6-0.80.0-0.2-0.8
Total infusions0.50.61.3-0.9-0.8-0.8-0.8-1.0-1.1-0.7-1.0-0.6-0.9-0.6-0.8-0.1-0.8-0.2-0.80.10.7
Bone: trabecular number0.30.52.70.0-0.80.1-0.5-0.2-0.90.30.7-0.30.7-0.6-1.4-0.4-0.4-1.60.30.4-0.5
Bone: trabecular spacing0.50.73.20.51.00.30.90.61.3-0.1-0.50.5-0.50.51.70.40.41.8-0.3-0.50.3
Bone: trabecular thickness1.41.76.6-0.4-1.8-0.4-1.3-1.0-1.70.00.6-1.20.8-1.5-2.6-1.1-1.2-2.50.10.2-1.2
Bone: trabecular tissue density0.10.20.4-0.6-0.5-0.6-0.4-0.40.2-0.5-0.5-0.4-0.6-0.2-0.4-0.20.10.2-0.0-0.3-0.1
Water consumed over 24 hours1.41.94.4-1.8-1.2-2.0-1.3-1.4-0.2-2.1-1.8-1.5-1.7-1.30.4-1.2-1.3-0.7-0.9-1.7-0.7
Number of responses in last shaping day0.20.20.9-0.30.1-0.1-0.0-0.1-0.1-0.1-0.90.1-0.70.40.10.40.50.7-0.4-0.10.6