Hub : Genes

Pes1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Pes1 0.04 0.02 1.8e-04 0.01 0.03 0.03 0.03 8.1e-03 3.7e-04 6.0e-04 7.1e-04
2 IL mRNA stability Pes1 0.2 0.1 2.2e-04 0.1 0.13 0.12 0.13 2.6e-03 4.4e-04 9.6e-04 5.8e-04
3 Liver mRNA stability Pes1 0.05 0.03 1.4e-05 0.05 0.03 0.04 0.05 1.9e-06 6.3e-04 1.6e-05 7.3e-06
4 Brain mRNA stability Pes1 0.22 0.08 0.0e+00 0.3 0.29 0.3 0.3 7.3e-28 1.8e-27 2.8e-28 2.4e-28
5 PL mRNA stability Pes1 0.09 0.04 1.4e-11 0.08 0.08 0.1 0.06 1.0e-08 4.0e-09 3.0e-11 4.1e-07
6 Brain intron excision ratio chr14_78850791_78856081 0.03 0.02 6.2e-03 0.01 0.02 0.02 0.01 8.0e-02 4.7e-03 6.6e-03 2.1e-02
7 NAcc mRNA stability Pes1 0.06 0.03 2.3e-06 0.06 0.04 0.04 0.05 1.2e-07 5.3e-06 2.5e-05 8.3e-07
8 pVTA intron excision ratio chr14_78856160_78857001 0.07 0.04 3.1e-03 0.03 0.02 0.01 0.04 1.7e-02 4.6e-02 1.6e-01 9.2e-03
9 PL intron excision ratio chr14_78856160_78857001 0.05 0.02 4.2e-06 0.07 0.05 0.05 0.06 7.4e-08 4.8e-06 2.5e-06 1.2e-06
10 BLA mRNA stability Pes1 0.05 0.03 6.1e-03 0.06 0.05 0.04 0.05 6.3e-04 1.4e-03 2.0e-03 1.5e-03
11 OFC gene expression Pes1 0.15 0.09 4.2e-03 0.14 0.1 0.1 0.1 3.4e-04 2.3e-03 1.8e-03 2.2e-03
12 OFC mRNA stability Pes1 0.15 0.09 7.3e-03 0.06 0.05 0.04 0.04 1.3e-02 2.4e-02 3.7e-02 3.1e-02
13 Adipose mRNA stability Pes1 0.13 0.06 1.1e-15 0.14 0.14 0.13 0.14 6.3e-15 9.5e-15 1.1e-14 2.9e-15
14 Adipose gene expression Pes1 0.05 0.03 4.2e-03 -0 0.01 0 -0 5.3e-01 6.1e-02 3.1e-01 5.6e-01
15 LHb mRNA stability Pes1 0.17 0.09 6.6e-03 -0.01 0.02 -0.01 -0 4.8e-01 9.1e-02 7.0e-01 3.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.40.74.0-0.6-0.50.9-0.40.2-1.40.6-0.91.00.5-0.30.8-0.5-2.0-0.3
Area under the delay curve9.410.012.82.93.1-3.03.1-3.23.0-3.53.6-3.6-3.4-2.4-3.33.32.83.0
BMI with tail1.34.18.52.52.5-0.81.3-1.61.7-2.12.0-2.0-1.7-0.8-2.51.72.92.6
BMI without tail0.61.24.52.11.8-0.00.6-1.10.6-1.00.6-0.6-0.8-1.2-1.00.51.21.1
Body weight2.29.116.14.03.9-2.13.1-3.32.6-3.22.8-2.7-3.1-2.8-3.22.72.62.5
Weight adjusted by age1.72.04.02.01.8-0.81.2-1.31.3-1.61.4-1.4-1.5-1.1-1.40.91.51.1
Bone surface0.20.40.70.50.6-0.60.8-0.70.3-0.80.5-0.5-0.8-0.5-0.60.80.10.7
Bone volume0.10.10.40.20.3-0.30.5-0.5-0.2-0.3-0.10.1-0.3-0.6-0.10.3-0.60.3
Breakpoint value in progressive ratio session0.20.20.70.30.4-0.20.5-0.40.4-0.50.7-0.70.0-0.4-0.80.30.20.5
Number of licking bursts0.91.03.91.71.4-1.31.2-1.30.5-0.50.4-0.3-0.7-2.0-0.20.40.00.1
Context. condit. distance diff. score1.61.93.8-1.4-1.42.0-1.71.4-1.61.5-1.11.01.51.31.2-1.3-1.0-0.7
Locomotion velocity, session 10.60.73.0-1.7-1.40.2-0.71.10.40.2-0.20.20.31.70.4-0.10.4-0.6
Locomotion distance, session 10.91.22.9-1.3-1.11.7-1.20.9-1.31.0-0.80.81.00.91.2-0.9-1.2-0.5
Locomotion velocity, session 21.41.67.4-2.7-2.30.3-0.91.3-0.10.7-0.80.80.71.70.7-0.3-1.0-1.5
Locomotion distance, session 22.33.27.5-2.7-2.41.6-2.02.2-1.31.5-1.61.61.72.61.4-1.1-0.8-0.8
Locomotion velocity, session 30.50.51.8-0.9-0.71.3-0.90.7-1.00.5-0.30.30.60.80.6-0.5-0.6-0.0
Locomotion distance, session 30.50.61.4-0.00.2-0.70.5-0.21.0-0.90.9-1.0-0.90.6-0.60.91.20.6
Stereotopy head waving bouts, day 31.31.62.5-1.3-1.31.6-1.31.1-1.31.1-1.21.21.20.91.3-1.2-1.4-1.2
Stereotopy head waving duration, day 32.12.54.3-1.6-1.62.1-1.81.6-1.61.4-1.61.61.61.31.7-1.6-1.2-1.1
Locomotion velocity, session 70.10.10.6-0.5-0.4-0.1-0.00.30.5-0.20.1-0.1-0.10.5-0.80.30.3-0.2
Locomotion distance, session 70.50.72.0-1.4-1.10.9-0.91.1-0.70.5-0.70.70.71.30.3-0.3-0.30.0
Stereotopy head waving bouts, day 70.10.10.80.40.5-0.10.2-0.30.1-0.40.3-0.3-0.3-0.1-0.00.30.50.9
Stereotopy head waving duration, day 70.50.61.31.11.1-0.40.6-0.80.4-0.70.7-0.7-0.7-0.6-0.40.50.81.0
Locomotion velocity, session 82.83.36.9-2.6-2.51.3-1.92.0-1.21.8-1.61.51.92.21.7-1.5-1.2-1.7
Locomotion distance, session 86.79.813.1-3.4-3.43.6-3.63.4-3.13.2-3.03.03.43.13.1-3.0-2.2-2.0
Degree of sensitization distance5.25.36.9-2.2-2.32.5-2.42.2-2.42.4-2.62.62.61.52.1-2.2-2.2-1.8
Degree of sensitization stereotypy0.80.81.81.31.3-0.80.9-0.90.6-0.80.8-0.8-0.8-0.8-0.60.70.91.1
Conditioned locomotion0.20.21.20.10.20.6-0.2-0.1-0.90.20.0-0.10.2-0.30.2-0.1-0.41.1
Cocaine response after cond. corrected1.01.22.00.71.0-1.01.3-1.40.7-1.31.2-1.2-1.3-1.2-0.71.30.11.0
Cocaine response after cond. not corrected2.42.74.91.61.8-1.31.9-2.21.0-1.81.8-1.8-1.9-2.1-1.21.80.11.2
Cocaine response before conditioning0.20.20.50.70.60.10.4-0.50.2-0.30.4-0.4-0.5-0.6-0.60.3-0.1-0.2
Saline control response0.91.24.7-1.8-1.61.2-1.31.6-0.30.6-0.30.20.72.20.2-0.60.1-0.7
Bone: connectivity density0.20.31.5-0.4-0.20.8-0.30.1-1.00.2-0.50.50.2-0.10.6-0.2-1.20.1
Bone: cortical apparent density0.10.10.30.50.4-0.1-0.0-0.00.00.00.0-0.00.0-0.2-0.2-0.10.50.6
Bone: cortical area3.55.29.83.12.8-2.02.3-2.42.4-2.12.3-2.3-2.2-2.0-2.51.72.21.0
Bone: cortical porosity0.50.51.00.60.7-0.50.9-1.00.1-0.70.7-0.7-0.9-1.0-0.60.8-0.40.5
Bone: cortical porosity0.10.10.20.40.4-0.30.4-0.4-0.1-0.30.2-0.2-0.4-0.5-0.30.4-0.30.3
Bone: cortical thickness2.74.510.33.22.9-1.72.1-2.31.8-1.82.0-2.0-1.9-2.1-2.21.41.91.3
Bone: cortical thickness0.20.31.21.10.90.60.0-0.3-0.6-0.10.1-0.1-0.1-0.30.4-0.20.31.0
Bone: cortical tissue density0.10.10.40.50.5-0.20.0-0.10.1-0.10.1-0.1-0.0-0.2-0.2-0.10.60.6
Condit. Reinf. active minus inactive responses0.30.41.1-0.8-0.5-0.10.00.30.8-0.60.3-0.3-0.41.1-0.60.80.90.4
Condit. Reinf. active-inactive response ratio1.11.25.7-2.0-1.70.1-0.91.50.50.2-0.40.50.52.40.2-0.10.9-0.4
Condit. Reinf. active responses0.10.20.7-0.6-0.40.2-0.20.40.4-0.3-0.20.2-0.10.9-0.20.30.60.1
Condit. Reinf. inactive responses0.30.31.51.21.00.10.5-0.8-0.1-0.10.0-0.0-0.3-1.2-0.20.1-0.2-0.0
Incentive salience index mean0.70.91.90.10.3-0.60.7-0.41.3-1.20.9-0.9-1.10.3-1.31.31.40.7
Condit. Reinf. lever presses0.81.01.71.11.1-0.60.9-0.91.2-1.10.9-0.9-1.2-0.5-1.31.11.30.8
Condit. Reinf. active minus inactive responses0.60.81.3-0.6-0.81.1-1.01.0-0.51.0-0.90.90.90.90.4-1.0-0.4-1.1
Condit. Reinf. active-inactive response ratio0.10.10.3-0.10.10.10.10.10.2-0.20.3-0.3-0.30.2-0.50.40.40.6
Condit. Reinf. active responses1.52.13.9-1.7-1.71.9-1.81.9-0.91.4-1.31.31.42.00.5-1.3-0.7-1.4
Condit. Reinf. inactive responses2.43.04.5-1.9-1.91.9-2.02.0-1.21.6-1.81.81.72.11.1-1.6-0.9-1.7
Condit. Reinf. lever presses0.30.41.0-0.5-0.61.0-0.91.0-0.30.6-0.50.50.61.0-0.3-0.60.1-0.4
Condit. Reinf. lever reinforcers received1.01.53.4-1.5-1.41.7-1.51.6-0.71.1-0.90.91.11.80.2-0.9-0.4-0.9
Conditioned reinforcement - actives2.02.02.51.11.3-1.41.5-1.31.4-1.51.5-1.5-1.4-1.1-1.51.41.51.6
Conditioned reinforcement - inactives2.83.24.61.31.5-1.91.9-1.81.9-2.12.2-2.2-1.7-1.1-2.11.91.51.4
Conditioned locomotion0.70.82.01.01.0-0.80.9-1.20.7-0.80.8-0.8-1.2-1.4-0.80.80.20.4
Patch foraging indifference point 0 sec0.10.10.40.60.4-0.30.2-0.30.2-0.10.1-0.10.1-0.6-0.1-0.20.2-0.0
Patch foraging indifference point AUC0.60.73.0-1.5-1.30.8-1.01.10.10.2-0.20.20.21.70.2-0.1-0.2-0.8
Delay disc. indifference point, 0s delay8.89.717.32.93.4-2.72.9-3.12.1-3.33.3-3.3-3.3-2.6-3.23.32.64.2
Delay disc. indifference point, 16s delay4.95.07.51.41.8-2.22.3-2.12.4-2.32.6-2.6-2.7-1.5-2.52.71.91.9
Delay disc. indifference point, 2s delay7.48.210.43.03.2-2.63.0-3.12.1-3.13.1-3.1-2.8-2.7-2.82.82.13.1
Delay disc. indifference point, 24s delay5.25.07.11.52.0-2.12.4-2.11.9-2.62.6-2.6-2.4-1.4-2.22.61.92.7
Delay disc. indifference point, 4s delay6.36.68.62.32.6-2.52.7-2.62.3-2.82.9-2.9-2.9-1.9-2.82.71.82.3
Delay disc. indifference point, 8s delay1.81.83.51.21.2-1.31.0-1.11.8-1.51.6-1.6-1.3-0.5-1.51.31.90.9
Indifference point function ln k0.20.31.80.60.50.20.5-0.7-0.60.1-0.20.20.1-1.3-0.2-0.0-1.2-0.1
Indifference point function log k0.20.31.80.60.50.20.5-0.7-0.60.1-0.20.20.1-1.3-0.2-0.0-1.2-0.1
Patch foraging total patch changes 0 sec0.10.10.30.60.4-0.50.2-0.30.5-0.20.3-0.3-0.1-0.4-0.2-0.10.5-0.1
Patch foraging total patch changes 12 sec0.10.10.40.60.5-0.00.0-0.30.3-0.30.4-0.4-0.3-0.3-0.20.10.40.3
Patch foraging total patch changes 18 sec0.40.52.1-0.2-0.1-0.80.10.21.3-0.70.6-0.6-0.60.9-0.40.41.40.0
Patch foraging total patch changes 24 sec2.02.44.5-1.6-1.61.8-2.12.1-1.01.4-1.41.41.62.11.5-1.60.2-0.6
Patch foraging total patch changes 6 sec0.10.10.4-0.2-0.2-0.10.00.00.6-0.40.4-0.5-0.30.1-0.30.20.3-0.4
Patch foraging time to switch 0 sec0.30.51.51.20.9-0.20.0-0.1-0.70.7-0.80.80.6-0.80.8-0.80.60.9
Patch foraging water rate 0 sec0.40.62.50.20.1-0.40.4-0.41.6-0.91.1-1.1-0.60.1-0.80.30.6-1.3
Patch foraging water rate 12 sec0.10.21.3-0.2-0.30.4-0.30.20.5-0.10.2-0.2-0.10.9-0.1-0.10.1-1.1
Patch foraging water rate 18 sec0.91.22.50.50.11.5-0.60.1-1.31.0-1.01.01.0-0.61.1-1.5-1.6-1.4
Patch foraging water rate 24 sec0.50.74.6-0.1-0.60.4-0.60.70.50.6-0.30.30.61.00.6-1.10.3-2.2
Patch foraging water rate 6 sec0.10.22.40.40.10.2-0.10.00.40.10.1-0.1-0.00.30.1-0.5-0.0-1.5
Seeking ratio, delayed vs. immediate footshock0.50.62.1-1.5-1.3-0.2-0.80.5-0.30.4-0.10.10.60.30.1-0.3-1.3-1.2
Distance traveled before self-admin0.10.20.6-0.7-0.60.2-0.30.5-0.2-0.1-0.10.10.20.50.10.0-0.8-0.2
Distance traveled after self-admin0.20.20.80.20.3-0.50.2-0.10.3-0.60.7-0.7-0.60.0-0.40.50.30.9
Extensor digitorum longus weight2.510.015.13.93.7-3.13.6-3.53.2-3.33.1-3.1-3.3-3.2-3.12.72.41.6
Bone: elastic displacement0.40.51.00.30.00.7-0.50.3-1.00.7-1.00.90.6-0.20.9-0.9-0.8-0.6
Bone: elastic work0.50.62.91.71.20.10.4-0.8-0.40.1-0.40.4-0.1-1.50.5-0.6-0.5-0.6
Bone: endosteal estimation0.00.00.40.10.0-0.10.00.00.20.1-0.10.2-0.2-0.1-0.0-0.1-0.2-0.6
Bone: endosteal perimeter0.51.11.81.00.9-1.21.1-1.01.4-1.11.1-1.0-1.3-0.8-1.21.10.80.1
Epididymis fat weight0.20.52.51.61.4-0.10.5-0.8-0.4-0.1-0.10.1-0.3-1.3-0.10.10.11.0
Delta time in closed arm before/after self-admin2.52.45.2-1.3-1.22.3-1.71.1-2.21.5-1.31.31.90.81.3-1.6-2.3-0.7
Delta time in open arm before/after self-admin4.03.96.71.51.5-2.61.9-1.62.6-1.82.2-2.2-1.9-1.0-2.22.12.51.2
Diff in mean of infusions in LGA sessions0.30.31.80.30.4-0.30.4-0.30.1-0.50.6-0.6-0.30.1-0.50.70.51.3
Delay discount exponential model param9.09.512.3-2.9-3.12.9-3.13.1-3.03.4-3.53.53.32.33.2-3.2-2.8-2.9
Extinction: sum of active levers before priming1.41.42.7-0.10.4-1.01.0-0.81.3-1.51.6-1.6-1.2-0.3-1.51.50.91.3
Active lever presses in extinction session 61.51.52.20.91.2-0.91.4-1.40.5-1.31.3-1.4-1.1-1.4-1.41.4-0.01.5
Bone: final force0.20.41.61.20.9-0.50.3-0.30.7-0.30.3-0.3-0.3-0.2-0.4-0.11.30.1
Bone: final moment0.20.41.61.30.9-0.60.5-0.50.6-0.30.3-0.2-0.3-0.5-0.4-0.10.9-0.1
Food consumed during 24 hour testing period0.30.41.9-0.8-0.8-0.3-0.20.60.90.1-0.20.20.30.8-0.2-0.30.5-1.4
Glucose7.911.931.80.20.9-4.73.4-2.05.6-4.03.9-3.9-3.60.2-3.53.94.51.1
Heart weight0.30.40.8-0.7-0.80.6-0.60.6-0.30.7-0.70.70.80.70.9-0.60.1-0.6
Delay discount hyperbolic model param9.610.113.2-3.0-3.23.0-3.23.2-3.03.5-3.63.63.42.33.3-3.3-2.9-3.0
Intermittent access intake day 1-15 change0.80.81.60.10.4-1.20.8-0.51.3-1.11.0-1.0-1.00.2-0.91.01.20.7
Intermittent access intake escalation0.40.40.80.10.3-0.90.5-0.40.9-0.80.7-0.7-0.60.1-0.70.70.80.5
Intermittent access intake escalation 20.20.20.7-0.2-0.4-0.3-0.30.40.20.3-0.40.40.60.30.4-0.50.1-0.8
Intermitt. access day 1 inactive lever presses0.20.20.9-0.7-0.50.9-0.40.4-0.1-0.10.1-0.10.20.6-0.1-0.2-0.3-0.4
Intermitt. access day 15 inactive lever presses0.80.83.40.20.2-0.80.5-0.01.8-0.91.0-1.0-0.60.8-1.00.51.8-0.3
Intermitt. access escalation Index0.20.21.1-0.3-0.30.7-0.50.60.10.1-0.10.1-0.01.10.1-0.30.80.0
Intermittent access day 1 total infusions0.50.61.51.11.0-1.20.6-0.60.5-0.40.5-0.5-0.6-0.4-0.50.51.11.1
Intermittent access day 15 total infusions1.51.73.61.11.2-1.91.2-1.01.4-1.21.2-1.2-1.4-0.3-1.21.21.81.4
Intermittent access terminal intake (last 3 days)0.40.51.70.60.5-1.30.6-0.40.9-0.50.5-0.5-0.70.0-0.50.51.10.6
Intermittent access total infusions0.60.72.00.80.8-1.40.9-0.80.8-0.60.7-0.7-0.9-0.5-0.70.80.80.7
Intermittent access day 1 locomotion1.01.01.6-1.0-1.10.6-1.21.2-1.01.3-1.21.20.91.01.2-1.1-0.5-0.4
Intermittent access day 15 total locomotion2.72.94.81.81.9-2.01.4-1.51.7-1.61.7-1.7-1.6-1.0-1.61.42.21.8
Intermittent access total locomotion0.70.81.50.40.6-1.20.8-0.71.0-0.91.0-1.0-1.0-0.1-1.01.01.11.0
Intermittent access standard deviation0.50.50.9-0.5-0.70.4-0.70.9-0.40.9-0.80.80.70.80.9-0.90.1-0.8
Left kidney weight0.30.91.90.50.11.1-0.60.4-1.41.0-1.31.31.0-0.30.9-1.2-1.2-0.7
Right kidney weight0.41.24.20.90.61.6-0.5-0.1-2.10.9-1.41.40.9-0.90.7-0.9-1.60.4
Cocaine induced anxiety0.50.62.0-0.1-0.0-1.20.7-0.41.4-0.80.8-0.8-0.90.0-0.80.90.7-0.6
Post-drug Anxiety0.40.41.1-0.00.1-1.10.8-0.41.0-0.80.7-0.7-0.4-0.3-0.80.60.5-0.1
Baseline Anxiety0.50.61.80.91.0-0.90.8-0.70.3-0.50.5-0.5-0.2-0.9-0.50.30.71.3
Tail length0.61.77.42.01.7-0.41.6-1.90.5-1.00.6-0.5-1.3-2.7-0.40.7-0.8-0.4
Length with tail0.83.08.22.62.2-1.32.3-2.51.2-1.61.2-1.1-1.8-2.9-1.01.2-0.00.0
Length without tail0.81.82.91.41.3-1.51.7-1.61.5-1.41.4-1.4-1.4-1.1-1.21.21.00.5
Times rat made contact with spout1.01.13.9-2.0-1.8-0.3-0.81.40.60.5-0.40.30.71.90.1-0.30.3-1.3
Lifetime Intake0.50.61.50.80.8-1.20.9-0.80.7-0.60.7-0.7-0.8-0.7-0.70.70.50.7
Liver weight, left2.94.710.3-1.3-1.52.6-2.11.6-3.22.3-2.22.12.30.72.3-2.3-3.2-1.1
Liver weight, right2.84.68.3-0.8-1.22.4-2.42.1-2.92.6-2.32.22.61.32.3-2.8-1.7-1.0
Locomotor activity0.20.31.3-0.5-0.6-1.00.40.11.0-0.30.2-0.2-0.20.5-0.00.20.2-1.2
Locomotor testing distance0.30.51.31.10.9-0.70.9-1.00.5-0.60.5-0.5-0.6-1.1-0.70.40.0-0.1
Locomotor testing rearing1.32.03.31.11.2-1.81.8-1.51.8-1.61.4-1.4-1.4-1.3-1.41.41.00.3
Locomotion in novel chamber0.20.30.90.20.20.9-0.40.2-1.00.5-0.50.50.6-0.10.5-0.6-0.40.4
Locomotion in novel chamber post-restriction1.51.84.4-2.1-1.81.2-1.71.9-0.91.2-1.11.11.31.91.0-0.9-0.2-0.2
Fecal boli incidents, locomotor time 10.70.81.6-1.3-1.20.9-0.90.9-0.60.7-0.60.60.81.10.7-0.7-1.0-0.9
Change in fecal boli incidents, locomotor task1.11.02.2-1.5-1.40.1-1.01.3-0.30.6-1.01.01.11.51.0-0.7-0.2-0.9
Time >=10cm from walls, locomotor time 10.30.31.40.60.6-0.1-0.2-0.0-0.50.2-0.40.40.4-0.70.2-0.30.61.2
Bouts of movement, locomotor time 10.30.31.0-0.20.1-0.30.4-0.20.6-0.60.4-0.4-0.70.5-0.30.81.00.9
Total resting periods, locomotor time 10.50.62.0-0.20.1-0.60.5-0.20.9-0.90.6-0.6-0.90.7-0.51.01.41.0
Rest time, locomotor task time 10.10.20.6-0.8-0.70.3-0.10.50.40.00.1-0.10.20.70.1-0.20.5-0.4
Distance moved, locomotor task time 10.20.20.60.70.4-0.1-0.2-0.0-0.60.8-0.50.50.3-0.30.5-0.5-0.6-0.2
Vertical activity count, locomotor time 10.40.41.0-0.4-0.50.1-0.50.5-0.80.9-0.70.70.40.50.9-0.4-1.0-0.3
Time >=10cm from walls, locomotor time 20.20.20.4-0.6-0.50.1-0.50.4-0.50.4-0.30.30.6-0.20.4-0.4-0.3-0.1
Bouts of movement, locomotor time 20.60.71.40.60.80.30.4-1.00.3-1.01.0-1.0-1.1-0.9-1.21.00.40.9
Total resting periods, locomotor time 20.80.81.70.60.80.20.4-0.90.6-1.11.1-1.1-1.2-0.6-1.31.10.81.0
Rest time, locomotor task time 20.40.50.9-0.8-0.91.0-0.50.7-0.30.4-0.60.60.61.00.7-0.6-0.1-0.7
Distance moved, locomotor task time 20.10.10.40.20.1-0.1-0.30.2-0.40.6-0.40.40.2-0.10.5-0.5-0.2-0.0
Vertical activity count, locomotor time 20.10.10.3-0.10.1-0.10.0-0.1-0.3-0.10.1-0.1-0.4-0.00.10.3-0.60.5
Light reinforcement 10.40.72.21.51.3-0.10.8-1.10.7-0.90.8-0.8-0.8-0.6-0.40.40.80.3
Light reinforcement 20.20.21.31.10.60.5-0.2-0.3-0.10.3-0.20.20.3-0.40.4-0.70.2-0.5
Bone: marrow area0.00.00.30.1-0.0-0.10.00.10.20.0-0.10.2-0.2-0.0-0.1-0.1-0.1-0.5
Bone: maximum diameter3.46.311.12.82.5-2.72.6-2.43.3-2.52.6-2.5-2.6-1.8-2.82.12.80.7
Bone: maximum force0.10.21.41.20.8-0.30.2-0.30.4-0.00.1-0.1-0.2-0.3-0.3-0.30.7-0.3
Bone: maximum moment0.10.21.51.20.8-0.40.3-0.40.40.00.1-0.1-0.2-0.7-0.3-0.30.2-0.6
Mean time between licks in bursts1.11.54.2-2.1-1.90.3-0.91.40.00.7-1.01.00.91.71.1-0.8-0.5-1.8
Mean num. licks in bursts2.12.69.8-3.0-2.61.1-1.72.2-0.20.9-0.70.71.13.10.4-0.60.1-1.0
Cd content in liver0.91.02.1-0.7-0.71.3-1.11.0-1.21.1-1.11.11.10.71.4-1.2-0.6-0.4
Co content in liver0.60.71.30.40.6-0.20.8-0.80.5-0.91.0-1.0-0.8-0.7-1.21.10.31.0
Cu content in liver0.10.10.5-0.00.2-0.10.4-0.5-0.1-0.40.3-0.2-0.2-0.6-0.10.4-0.40.7
Fe content in liver1.51.86.2-2.5-2.20.6-1.31.8-0.20.8-0.90.91.02.00.9-0.7-0.6-1.3
K content in liver1.71.72.91.51.6-0.81.5-1.70.5-1.31.3-1.3-1.4-1.7-1.11.30.11.5
Mg content in liver2.93.04.41.92.0-1.42.0-2.11.4-1.81.8-1.8-1.8-1.9-1.81.70.91.3
Mn content in liver0.20.30.60.40.5-0.20.5-0.7-0.2-0.50.4-0.4-0.6-0.6-0.70.8-0.70.4
Na content in liver5.15.48.21.21.6-2.82.5-1.92.9-2.82.7-2.6-2.7-0.9-2.52.72.11.6
Rb content in liver1.01.31.81.31.3-1.11.3-1.21.0-1.11.2-1.1-1.3-1.3-0.81.10.71.0
Se content in liver1.61.93.81.51.5-1.51.7-1.81.2-1.41.3-1.2-1.5-2.0-1.21.40.30.5
Sr content in liver0.40.41.70.1-0.1-1.00.30.11.3-0.30.3-0.3-0.20.6-0.30.11.3-0.7
Zn content in liver0.20.32.10.40.0-0.20.1-0.10.30.2-0.50.50.3-0.50.5-0.7-0.3-1.4
Bone: minimum diameter0.00.10.40.50.30.3-0.0-0.20.00.20.00.0-0.1-0.3-0.1-0.2-0.2-0.6
Time in familiar zone, hab. session 11.61.52.2-1.0-1.20.7-1.31.5-1.01.4-1.51.51.31.31.4-1.3-0.4-0.8
Time in novel zone, hab. session 10.90.92.11.11.1-0.61.1-1.30.6-0.91.1-1.1-0.8-1.4-1.00.7-0.20.2
Total zone transitions, hab. session 10.71.02.6-1.5-1.40.6-1.11.4-0.50.9-0.70.70.91.60.8-0.7-0.2-0.8
Total locomotion distance, hab. session 10.10.21.1-1.0-0.80.0-0.20.50.0-0.0-0.10.1-0.10.70.10.3-0.3-0.2
Locomotion velocity, hab. session 10.20.31.3-1.2-0.90.2-0.40.60.1-0.0-0.10.10.01.00.10.20.1-0.1
Time in familiar zone, hab. session 23.13.24.6-1.6-1.61.9-2.11.8-2.12.1-2.02.01.91.41.9-1.8-1.4-0.7
Time in novel zone, hab. session 22.22.24.01.71.5-1.71.6-1.42.0-1.51.5-1.5-1.3-1.2-1.61.11.5-0.0
Total zone transitions, hab. session 20.10.20.7-0.3-0.3-0.20.10.20.7-0.30.3-0.3-0.30.8-0.10.20.8-0.2
Total locomotion distance, hab. session 20.20.31.4-0.2-0.2-0.70.30.01.2-0.50.3-0.3-0.40.6-0.30.41.1-0.4
Locomotion velocity, hab. session 20.40.51.80.10.1-0.90.7-0.31.3-0.90.6-0.6-0.70.3-0.50.71.1-0.0
Novel to familiar place preference ratio2.12.23.60.10.5-1.51.3-0.91.9-1.81.8-1.9-1.50.2-1.81.91.81.2
Novelty place preference1.92.03.40.20.5-1.41.2-0.91.8-1.71.8-1.8-1.40.1-1.71.81.61.0
Time in novel zone, NPP test1.61.63.00.10.4-1.21.1-0.81.7-1.51.6-1.7-1.30.2-1.61.61.60.8
Total zone transitions, NPP test0.10.10.50.00.10.7-0.2-0.1-0.50.3-0.0-0.00.1-0.10.0-0.1-0.40.3
Total locomotion distance, NPP test0.10.10.4-0.00.20.10.2-0.2-0.0-0.20.2-0.2-0.3-0.2-0.50.5-0.00.6
Locomotion velocity, NPP test0.20.31.00.10.4-0.20.5-0.60.2-0.50.6-0.6-0.6-0.4-0.70.90.11.0
Intraocular pressure0.40.62.7-0.6-0.7-0.6-0.31.00.9-0.0-0.40.40.21.60.1-0.21.6-0.4
Delta distance traveled before/after self-admin0.60.61.60.80.9-0.80.6-0.60.5-0.50.6-0.6-1.0-0.4-0.50.81.21.3
Delta ambulatory time before/after self-admin0.10.10.90.10.2-0.20.2-0.2-0.20.00.1-0.1-0.5-0.20.10.50.31.0
Parametrial fat weight1.01.94.6-0.30.1-1.61.1-0.42.0-1.61.4-1.4-1.30.9-1.41.82.11.2
Pavlov. Cond. lever latency0.20.20.5-0.3-0.0-0.70.6-0.40.6-0.60.7-0.7-0.6-0.2-0.10.5-0.00.0
Pavlov. Cond. magazine entry latency1.11.42.0-1.3-1.41.2-1.41.4-1.01.2-1.21.21.11.41.0-1.1-0.8-1.0
Pavlov. Cond. change in total contacts0.50.51.40.10.2-1.00.5-0.11.0-0.80.6-0.6-0.70.4-1.00.91.20.6
Pavlov. Cond. index score0.91.11.8-0.9-1.01.3-1.31.2-1.11.1-1.11.11.21.20.7-1.0-0.5-0.4
Pavlov. Cond. latency score0.81.11.8-0.7-0.91.3-1.31.2-1.11.2-1.11.11.21.10.7-1.0-0.5-0.5
Pavlov. Cond. lever contacts0.30.40.7-0.2-0.30.9-0.80.6-0.60.7-0.70.70.80.60.2-0.60.0-0.3
Pavlov. Cond. magazine entry number1.21.53.51.71.6-1.21.5-1.60.8-1.01.0-1.0-1.1-1.9-0.70.90.50.8
Pavlov. Cond. intertrial magazine entries0.91.13.71.41.40.11.1-1.4-0.1-0.70.7-0.7-0.9-1.9-1.00.8-0.60.9
Pavlov. Cond. lever-magazine prob. diff.0.91.12.0-0.9-1.01.4-1.31.2-1.11.1-1.21.21.21.10.7-1.0-0.6-0.5
Pavlov. Cond. response bias0.10.10.3-0.5-0.40.6-0.40.4-0.30.2-0.30.40.30.5-0.1-0.1-0.2-0.0
Pavlov. Cond. lever latency1.72.45.52.22.1-1.62.0-2.10.8-1.50.9-0.8-1.5-2.4-0.41.20.31.1
Pavlov. Cond. magazine entry latency0.10.10.20.40.3-0.30.2-0.10.3-0.10.2-0.2-0.3-0.1-0.40.20.40.1
Pavlov. Cond. change in total contacts0.71.02.9-1.2-1.20.9-1.31.5-0.51.1-0.70.60.91.70.1-0.80.1-0.7
Pavlov. Cond. index score0.70.92.4-1.2-1.21.1-1.31.4-0.51.0-0.60.60.91.50.2-0.8-0.0-0.7
Pavlov. Cond. latency score0.70.92.1-1.1-1.21.1-1.31.3-0.61.0-0.60.60.91.50.2-0.8-0.2-0.8
Pavlov. Cond. lever contacts2.12.97.0-2.5-2.31.7-2.22.4-1.01.6-1.11.11.62.60.4-1.3-0.4-1.1
Pavlov. Cond. magazine entry number0.00.00.3-0.20.00.20.1-0.2-0.3-0.30.00.0-0.1-0.10.10.2-0.50.4
Pavlov. Cond. intertrial magazine entries0.00.10.3-0.4-0.10.5-0.0-0.1-0.2-0.20.00.00.0-0.1-0.30.2-0.50.1
Pavlov. Cond. lever-magazine prob. diff.0.81.02.3-1.1-1.21.0-1.31.4-0.61.1-0.80.71.01.50.3-0.9-0.2-0.8
Pavlov. Cond. response bias1.01.33.4-1.6-1.51.0-1.51.6-0.51.2-0.80.71.11.80.0-0.80.0-0.8
Time in closed arm before self-admin0.30.40.80.2-0.10.7-0.50.4-0.50.7-0.90.90.2-0.20.9-0.8-0.3-0.9
Time in closed arm after self-admin2.32.45.2-0.8-0.92.3-1.60.9-2.11.5-1.71.71.40.11.5-1.7-2.2-1.3
Time in open arm before self-admin0.00.00.1-0.00.10.20.1-0.2-0.20.1-0.00.00.3-0.00.1-0.1-0.20.1
Time in open arm after self-admin1.01.13.70.20.4-1.20.8-0.41.7-0.81.3-1.3-0.70.4-1.21.01.90.7
Bone: periosteal estimation0.81.63.71.91.6-1.21.3-1.31.5-1.11.2-1.2-1.3-1.2-1.40.81.20.1
Bone: periosteal perimeter2.84.76.72.62.4-2.12.2-2.22.4-2.12.2-2.2-2.3-1.8-2.41.92.11.1
Bone: post-yield work0.10.10.5-0.2-0.3-0.50.1-0.10.00.3-0.10.10.1-0.20.0-0.0-0.7-0.7
Progressive ratio test 1 active lever presses1.71.83.10.50.9-1.51.4-1.21.3-1.61.8-1.8-1.5-0.4-1.61.60.91.4
Progressive ratio test 1 breakpoint1.51.52.60.50.9-1.21.3-1.11.1-1.41.6-1.6-1.4-0.4-1.51.50.81.5
Progressive ratio test 1 inactive lever presses3.03.35.01.41.6-1.81.9-1.72.1-2.12.2-2.2-1.9-1.0-2.21.81.31.1
Progressive ratio test 2 active lever presses0.80.93.20.60.7-1.81.0-0.80.9-0.80.8-0.8-0.7-0.5-0.80.91.01.1
Progressive ratio test 2 breakpoint0.70.83.10.40.5-1.70.8-0.51.0-0.70.8-0.8-0.7-0.1-0.80.91.20.9
Progressive ratio test 2 inactive lever presses2.93.49.01.71.6-2.81.6-1.42.4-1.71.7-1.7-1.7-0.4-1.71.53.01.3
Incentive Sensitization - Responses0.40.42.40.50.5-1.50.6-0.30.7-0.30.2-0.2-0.1-0.0-0.20.51.20.7
Incentive Sensitization - Breakpoint0.40.52.40.70.6-1.60.6-0.40.7-0.20.2-0.2-0.1-0.1-0.20.41.30.7
Sum of active levers in priming session hrs 5-61.21.21.91.01.2-1.01.1-1.20.8-1.21.3-1.3-0.7-1.0-1.30.90.81.4
Progressive ratio0.10.10.90.60.4-1.00.4-0.40.00.1-0.00.00.1-0.50.20.20.00.0
Food seeking constrained by brief footshock2.73.35.92.42.3-2.32.2-2.01.3-1.61.7-1.7-1.6-1.6-1.61.71.01.6
Seeking ratio, punishment vs. effort0.91.11.81.01.2-0.51.1-1.00.9-1.31.2-1.2-1.3-0.7-1.41.00.60.7
Retroperitoneal fat weight0.10.32.00.00.1-0.10.00.30.4-0.40.0-0.0-0.11.0-0.00.31.41.0
Reaction time number correct0.81.25.4-1.1-1.40.4-0.91.10.01.0-1.01.01.11.11.0-1.1-0.5-2.3
Reaction time mean minus median0.00.00.1-0.4-0.3-0.2-0.0-0.00.10.10.1-0.10.2-0.20.00.0-0.1-0.1
Reaction time mean minus median AUC0.30.30.60.70.7-0.50.5-0.80.5-0.40.6-0.6-0.4-0.8-0.40.40.50.5
Reaction time num false alarms1.31.73.81.61.7-0.81.2-1.20.8-1.11.4-1.4-1.3-0.8-1.51.21.32.0
Reaction time num false alarms AUC1.21.63.82.01.9-0.71.1-1.20.5-0.91.2-1.1-1.2-1.1-1.20.91.21.9
Reaction time trials correct on left0.81.25.4-1.1-1.40.4-0.91.10.01.0-1.01.01.11.11.0-1.1-0.5-2.3
Reaction time trials on left0.91.35.4-1.1-1.40.4-0.91.1-0.01.0-1.01.01.11.11.0-1.1-0.6-2.3
Reaction time mean0.10.10.2-0.1-0.00.0-0.0-0.1-0.50.3-0.10.00.4-0.50.3-0.2-0.50.4
Reaction time mean AUC0.10.10.4-0.00.00.2-0.1-0.1-0.60.3-0.10.10.4-0.50.4-0.3-0.60.4
Median of all reaction times0.10.10.5-0.10.10.2-0.0-0.1-0.70.3-0.10.10.4-0.60.3-0.2-0.60.6
Reaction time omissions0.00.10.3-0.5-0.30.4-0.10.0-0.3-0.0-0.10.20.00.40.10.2-0.20.2
Reaction time false alarm rate2.23.08.12.52.5-0.91.6-1.80.4-1.31.6-1.6-1.6-1.7-1.61.41.32.8
Reaction time premature initiation rate2.63.57.5-1.3-1.42.7-2.22.0-2.21.7-2.12.11.91.71.8-1.9-1.4-0.9
Reaction time premature initiations2.83.95.6-1.7-1.92.4-2.22.2-1.71.8-2.22.22.02.01.9-2.1-1.3-1.9
Std. dev. reaction times0.00.00.2-0.1-0.0-0.40.1-0.10.20.10.0-0.10.2-0.20.1-0.00.30.3
Reaction time trials completed0.91.35.4-1.1-1.40.4-0.91.1-0.01.0-1.01.01.11.11.0-1.1-0.6-2.3
Reaction time trials AUC0.81.15.2-1.0-1.30.4-0.81.0-0.00.9-0.90.91.00.90.9-1.0-0.6-2.3
Run reversals in cocaine runway, females0.30.31.0-0.4-0.30.3-0.40.7-0.50.3-0.40.50.21.00.6-0.00.40.9
Run reversals in cocaine runway, males0.00.00.10.30.20.20.1-0.20.3-0.30.1-0.1-0.3-0.2-0.20.10.2-0.1
Latency to leave start box in cocaine runway0.40.41.00.10.3-0.20.6-0.30.4-0.70.9-0.9-0.9-0.2-0.80.90.41.0
Latency to leave start box in cocaine runway, F0.50.51.31.11.0-0.30.5-0.50.6-0.60.8-0.8-0.7-0.4-0.70.41.10.8
Latency to leave start box in cocaine runway, M0.40.42.0-1.4-0.90.20.20.1-0.1-0.40.5-0.5-0.50.2-0.31.0-0.90.2
Std. dev. time between licks in bursts1.11.32.3-1.5-1.51.0-1.11.3-0.91.0-1.21.21.11.21.2-1.1-1.0-1.1
Total sessions with >9 infusions0.00.00.30.10.10.5-0.10.1-0.10.00.1-0.10.20.1-0.0-0.2-0.2-0.1
Short access day 1 total inactive lever presses1.11.22.11.31.2-1.41.3-1.21.3-1.11.2-1.2-1.2-0.8-1.21.10.5-0.0
Short access day 10 total inactive lever presses0.30.31.7-0.6-0.61.3-0.40.3-0.30.1-0.10.10.20.60.1-0.2-0.8-1.0
Short access day 1 total infusions0.20.20.70.70.70.10.6-0.6-0.1-0.30.4-0.4-0.2-0.8-0.40.3-0.20.5
Short access day 10 total infusions0.10.10.2-0.1-0.20.1-0.30.2-0.40.4-0.30.30.30.00.3-0.3-0.4-0.2
Short access total infusions0.10.10.30.50.40.00.2-0.3-0.30.1-0.00.0-0.1-0.50.0-0.0-0.5-0.0
Short access day 1 locomotion1.31.42.7-0.2-0.51.7-1.20.7-1.41.3-1.21.21.2-0.01.2-1.6-1.5-1.3
Short access day 10 total locomotion2.42.74.9-2.2-2.11.7-1.81.7-1.51.5-1.51.51.21.61.5-1.3-1.8-1.4
Short access total locomotion4.54.76.3-1.9-2.12.5-2.42.2-2.22.3-2.22.21.91.62.2-2.3-2.2-2.1
One hour access (0.3 mA shock)0.30.41.30.30.4-1.10.7-0.60.6-0.60.6-0.6-0.7-0.4-0.60.70.40.7
Compulsive drug intake3.53.56.8-2.0-1.82.6-1.91.7-2.51.8-1.91.91.81.01.8-1.5-2.3-0.8
One hour access (shock baseline)3.23.77.81.31.5-2.82.1-1.92.2-1.92.0-2.0-2.2-1.3-2.02.11.61.3
Social response proportion0.30.41.4-0.9-0.9-0.5-0.00.30.70.2-0.40.50.40.50.8-0.40.4-1.2
Social responses0.20.31.1-0.5-0.6-0.70.20.21.0-0.1-0.40.40.20.30.2-0.20.6-1.1
Social time0.70.91.4-1.2-1.20.4-0.80.8-0.71.1-1.21.21.10.41.2-0.9-0.6-1.0
Soleus weight0.51.66.02.51.9-1.21.4-1.61.0-0.80.6-0.6-1.0-2.1-0.80.30.2-0.6
Bone: stiffness0.10.10.50.20.20.4-0.30.20.10.00.5-0.5-0.00.4-0.7-0.00.70.5
Tibialis anterior weight1.34.36.42.42.3-2.52.4-2.22.4-2.11.9-1.9-2.1-1.9-2.01.81.90.9
Time to tail flick, vehicle, before self-admin0.30.31.31.10.9-0.90.5-0.40.2-0.40.1-0.1-0.0-0.2-0.40.10.90.7
Time to tail flick, vehicle, after self-admin0.10.11.1-0.4-0.40.0-0.30.4-0.40.0-0.10.10.31.10.30.00.00.4
Time to tail flick, test, before self-admin0.70.71.3-0.7-0.81.1-0.90.9-0.60.8-0.80.81.10.80.4-0.9-0.6-1.1
Time to tail flick, test, after self-admin0.80.82.11.41.0-0.70.9-1.01.2-0.70.9-0.9-0.2-0.8-1.10.20.7-0.7
Delta time to tail flick, vehicle, before/after SA0.30.31.3-1.1-0.90.5-0.50.7-0.50.3-0.20.20.51.00.5-0.1-0.40.1
Delta time to tail flick, test, before/after SA0.90.81.31.10.9-1.01.0-1.11.1-0.81.1-1.1-0.7-0.8-0.80.70.7-0.0
Tibia length0.20.61.81.30.90.6-0.1-0.3-1.10.7-0.60.60.5-1.20.4-0.8-0.90.1
Ambulatory time before self-admin0.10.11.2-0.5-0.40.2-0.20.3-0.50.0-0.10.10.10.00.1-0.1-1.1-0.0
Ambulatory time after self-admin0.10.10.7-0.4-0.1-0.0-0.00.1-0.2-0.20.3-0.3-0.30.1-0.10.5-0.40.8
Bone: tissue strength1.21.14.30.0-0.60.4-0.80.7-0.51.4-1.31.31.30.00.9-1.5-0.8-2.1
Total heroin consumption0.10.10.40.10.10.50.0-0.3-0.20.00.1-0.2-0.0-0.6-0.3-0.0-0.6-0.0
Bone: trabecular number0.20.42.40.20.20.60.1-0.5-1.10.1-0.40.4-0.0-0.90.4-0.0-1.60.2
Bone: trabecular spacing0.50.63.30.40.2-1.30.50.01.5-0.50.6-0.6-0.40.5-0.40.21.8-0.3
Bone: trabecular thickness1.21.56.6-0.3-0.31.6-0.80.1-2.11.1-1.21.20.9-0.71.3-0.9-2.6-0.2
Bone: trabecular tissue density0.20.30.8-0.8-0.70.2-0.70.7-0.20.6-0.30.30.60.90.1-0.30.1-0.1
Water consumed over 24 hours1.51.84.5-1.8-2.00.1-1.11.6-0.11.3-1.31.31.41.51.0-1.2-0.5-2.1
Number of responses in last shaping day0.20.20.4-0.2-0.10.7-0.60.7-0.40.4-0.30.30.20.60.3-0.30.20.5