Pelo

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Pelo	0.19	0.12	9.6e-03	0.06	-0	0	0.03	1.3e-02	3.8e-01	3.3e-01	7.2e-02
2	IC	gene expression	Pelo	0.13	0.07	9.3e-05	0.11	0.07	0.07	0.08	2.2e-05	7.9e-04	5.3e-04	2.3e-04
3	pVTA	gene expression	Pelo	0.12	0.06	2.1e-08	0.1	0.12	0.12	0.1	9.6e-09	6.3e-10	7.4e-10	8.1e-09
4	PL	gene expression	Pelo	0.06	0.03	1.2e-07	0.05	0.06	0.06	0.06	2.4e-06	4.4e-07	1.3e-07	2.2e-07
5	Brain	gene expression	Pelo	0.04	0.03	1.3e-03	0.02	0.03	0.02	0.02	4.3e-03	1.0e-03	8.0e-03	2.7e-03
6	Liver	gene expression	Pelo	0.03	0.02	9.1e-03	-0	0.01	0	-0	7.1e-01	6.0e-02	2.6e-01	4.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	3.0	5.5	7.8	-2.5	-2.5	2.4	-2.8	1.5	-2.1
Area under the delay curve	0.7	1.1	3.0	0.8	0.7	-0.5	1.6	-0.1	1.7
BMI with tail	1.3	4.4	6.0	-2.5	-2.1	2.3	-2.1	1.5	-2.0
BMI without tail	2.4	12.5	17.2	-4.1	-4.1	4.1	-3.2	3.6	-1.3
Body weight	1.2	5.4	9.4	-3.1	-2.4	2.7	-1.8	2.2	-1.4
Weight adjusted by age	0.0	0.1	0.3	-0.4	-0.6	0.0	0.0	0.3	-0.1
Bone surface	2.0	3.8	7.9	-2.2	-1.7	1.6	-2.2	0.5	-2.8
Bone volume	1.5	2.9	6.8	-1.8	-1.4	1.3	-2.0	0.3	-2.6
Breakpoint value in progressive ratio session	0.1	0.3	0.8	-0.5	-0.4	0.6	-0.1	0.9	0.2
Number of licking bursts	0.1	0.3	0.8	0.2	-0.6	0.4	0.1	0.5	0.9
Context. condit. distance diff. score	0.5	0.7	2.5	0.2	0.0	-0.3	-0.7	-0.9	-1.6
Locomotion velocity, session 1	0.2	0.2	0.5	0.1	0.5	-0.5	-0.1	-0.7	-0.7
Locomotion distance, session 1	2.0	2.6	6.8	-1.8	-0.9	0.8	-2.0	-0.0	-2.6
Locomotion velocity, session 2	1.0	1.2	2.2	-1.1	-1.1	1.3	-0.5	1.5	0.6
Locomotion distance, session 2	1.3	1.8	4.3	-1.4	-0.9	0.9	-1.6	0.2	-2.1
Locomotion velocity, session 3	0.8	0.9	2.2	-0.4	-0.7	0.7	0.2	1.4	1.5
Locomotion distance, session 3	0.0	0.0	0.1	-0.2	0.0	-0.1	0.1	0.2	0.3
Stereotopy head waving bouts, day 3	3.7	4.4	8.3	-2.0	-2.2	2.6	-1.2	2.9	1.1
Stereotopy head waving duration, day 3	2.1	2.6	5.4	-0.9	-1.7	1.9	-0.6	2.3	1.6
Locomotion velocity, session 7	0.2	0.2	0.4	0.3	0.3	-0.4	0.6	-0.2	0.5
Locomotion distance, session 7	0.9	1.2	1.8	1.3	1.0	-1.0	1.3	-0.7	1.1
Stereotopy head waving bouts, day 7	0.6	0.7	1.3	-0.8	-0.9	1.1	-0.6	1.1	0.1
Stereotopy head waving duration, day 7	1.1	1.3	2.0	-1.0	-1.4	1.4	-1.0	1.4	0.0
Locomotion velocity, session 8	0.6	0.7	1.4	0.5	1.0	-1.0	0.6	-1.2	-0.6
Locomotion distance, session 8	1.5	2.2	9.6	-0.5	-0.1	-0.2	-1.2	-1.3	-3.1
Degree of sensitization distance	0.4	0.4	0.9	0.9	0.6	-0.6	0.8	-0.4	0.5
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.4	-0.5	0.5	-0.5	0.4	-0.3
Conditioned locomotion	0.4	0.5	1.0	-0.7	-0.9	0.8	-0.3	1.0	0.3
Cocaine response after cond. corrected	0.6	0.9	1.5	-1.2	-1.2	0.9	-1.0	0.6	-0.6
Cocaine response after cond. not corrected	0.0	0.0	0.1	0.0	0.1	-0.2	0.2	-0.3	0.0
Cocaine response before conditioning	5.3	6.4	8.8	3.0	2.9	-2.8	2.6	-2.3	1.1
Saline control response	0.1	0.2	0.6	-0.1	0.5	-0.2	0.8	-0.1	0.1
Bone: connectivity density	3.0	4.8	7.4	-2.3	-2.4	2.3	-2.7	1.6	-1.8
Bone: cortical apparent density	4.1	6.5	10.0	3.2	2.9	-2.8	2.5	-2.4	1.2
Bone: cortical area	0.2	0.3	1.1	-0.6	-0.2	0.1	-0.6	-0.3	-1.0
Bone: cortical porosity	1.5	1.6	2.2	-1.5	-1.3	1.3	-1.5	1.0	-0.8
Bone: cortical porosity	0.8	0.9	1.6	-1.2	-0.9	1.0	-1.0	0.6	-0.9
Bone: cortical thickness	0.6	0.9	1.5	1.1	1.1	-1.2	0.6	-1.2	0.1
Bone: cortical thickness	2.8	3.4	4.6	2.1	2.1	-1.9	2.1	-1.5	1.2
Bone: cortical tissue density	4.0	6.3	9.5	3.1	2.8	-2.7	2.5	-2.3	1.2
Condit. Reinf. active minus inactive responses	1.2	1.4	3.2	0.9	1.8	-1.3	0.7	-1.5	-0.3
Condit. Reinf. active-inactive response ratio	1.4	1.5	3.5	1.1	1.9	-1.3	1.1	-1.2	0.5
Condit. Reinf. active responses	1.2	1.6	3.4	0.9	1.8	-1.4	0.8	-1.6	-0.4
Condit. Reinf. inactive responses	0.6	0.8	1.6	0.4	0.8	-0.9	0.3	-1.3	-1.2
Incentive salience index mean	0.5	0.6	1.1	0.2	0.9	-0.6	-0.4	-1.1	-1.0
Condit. Reinf. lever presses	0.7	1.1	3.4	-0.9	-0.5	0.3	-1.4	-0.4	-1.8
Condit. Reinf. active minus inactive responses	1.5	2.2	3.7	0.8	1.9	-1.9	1.3	-1.8	-0.9
Condit. Reinf. active-inactive response ratio	1.0	1.6	2.8	0.2	1.3	-1.5	0.7	-1.7	-1.6
Condit. Reinf. active responses	0.5	0.8	1.6	0.7	1.3	-1.0	0.8	-0.8	-0.1
Condit. Reinf. inactive responses	0.4	0.6	1.8	0.9	0.6	-0.2	0.6	0.3	1.3
Condit. Reinf. lever presses	4.7	6.8	9.7	2.8	3.1	-3.1	2.0	-3.1	-0.6
Condit. Reinf. lever reinforcers received	1.2	1.7	3.0	1.2	1.7	-1.6	1.2	-1.3	-0.0
Conditioned reinforcement - actives	0.1	0.4	0.9	0.6	0.5	-0.5	0.9	-0.4	0.4
Conditioned reinforcement - inactives	0.3	0.7	1.2	0.9	0.8	-1.0	0.9	-1.1	-0.0
Conditioned locomotion	1.0	1.4	2.7	1.3	1.3	-1.0	1.6	-0.6	1.1
Patch foraging indifference point 0 sec	0.7	2.0	3.5	1.3	1.6	-1.7	0.6	-1.9	-0.9
Patch foraging indifference point AUC	0.1	0.3	0.6	-0.3	-0.8	0.5	-0.5	0.7	0.4
Delay disc. indifference point, 0s delay	0.7	0.8	3.2	0.5	0.3	-0.3	1.1	0.2	1.8
Delay disc. indifference point, 16s delay	0.4	0.6	1.0	0.6	0.7	-0.9	1.0	-0.9	-0.1
Delay disc. indifference point, 2s delay	0.6	0.7	1.9	-0.4	-0.5	0.6	0.7	1.0	1.4
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.3	0.2	0.2	0.5	0.3	0.2
Delay disc. indifference point, 4s delay	2.4	2.6	7.8	1.5	1.0	-0.8	1.9	-0.1	2.8
Delay disc. indifference point, 8s delay	0.4	0.6	2.7	0.5	0.2	0.0	0.8	0.3	1.6
Indifference point function ln k	0.4	1.2	2.2	1.0	1.5	-1.2	1.0	-1.2	0.0
Indifference point function log k	0.4	1.2	2.2	1.0	1.5	-1.2	1.0	-1.2	0.0
Patch foraging total patch changes 0 sec	0.5	1.5	2.4	1.2	1.4	-1.5	0.6	-1.6	-0.6
Patch foraging total patch changes 12 sec	0.0	0.0	0.2	0.2	-0.1	0.2	-0.4	0.0	-0.1
Patch foraging total patch changes 18 sec	0.2	0.6	1.1	0.7	1.0	-0.9	0.5	-0.9	0.1
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	-0.2	0.1	0.1	-0.1	0.3	0.2
Patch foraging total patch changes 6 sec	0.1	0.2	0.8	-0.0	0.2	-0.2	-0.2	-0.3	-0.9
Patch foraging time to switch 0 sec	0.1	0.3	0.6	0.1	0.6	-0.4	0.1	-0.7	-0.8
Patch foraging water rate 0 sec	0.3	1.1	4.7	0.4	-0.3	0.4	0.3	1.0	2.2
Patch foraging water rate 12 sec	0.5	2.0	3.5	-1.7	-1.6	1.5	-0.6	1.9	0.6
Patch foraging water rate 18 sec	0.2	0.5	1.3	-1.2	-0.6	0.6	0.2	0.8	0.2
Patch foraging water rate 24 sec	0.1	0.1	0.5	-0.7	-0.2	0.1	0.0	0.0	-0.5
Patch foraging water rate 6 sec	0.3	0.4	1.6	0.1	0.1	-0.2	0.8	0.2	1.3
Seeking ratio, delayed vs. immediate footshock	0.6	0.8	1.7	-0.6	-0.8	1.1	-0.3	1.3	1.0
Distance traveled before self-admin	0.7	1.5	6.0	-0.8	-0.4	-0.0	-1.3	-0.8	-2.4
Distance traveled after self-admin	0.6	1.1	2.6	0.6	0.7	-1.3	-0.0	-1.6	-1.3
Extensor digitorum longus weight	2.2	8.6	15.8	-2.8	-2.9	3.1	-4.0	2.2	-2.2
Bone: elastic displacement	0.1	0.1	0.3	-0.4	-0.2	0.5	-0.3	0.6	0.2
Bone: elastic work	0.1	0.1	0.2	-0.3	0.4	-0.0	0.4	-0.1	-0.2
Bone: endosteal estimation	0.8	2.0	3.7	-1.9	-1.3	1.5	-1.1	1.0	-1.4
Bone: endosteal perimeter	1.8	4.3	8.3	-2.9	-1.9	2.1	-1.9	1.5	-1.9
Epididymis fat weight	0.1	0.7	1.2	-1.1	-0.6	1.0	-0.9	0.6	-0.7
Delta time in closed arm before/after self-admin	0.4	0.4	1.6	0.4	0.3	0.0	0.7	0.4	1.3
Delta time in open arm before/after self-admin	0.4	0.5	1.0	0.5	0.3	-0.6	-0.5	-1.0	-0.9
Diff in mean of infusions in LGA sessions	0.4	0.7	1.7	0.6	1.0	-0.9	1.3	-0.6	0.3
Delay discount exponential model param	0.9	1.2	3.3	-0.7	-0.6	0.4	-1.6	-0.1	-1.8
Extinction: sum of active levers before priming	0.6	1.0	1.9	-1.1	-1.2	1.1	-0.4	1.4	0.3
Active lever presses in extinction session 6	0.6	0.6	1.5	-0.6	-0.7	0.9	-0.1	1.2	0.7
Bone: final force	1.3	2.1	6.5	-0.0	0.9	-1.2	-0.2	-2.0	-2.6
Bone: final moment	1.1	1.8	6.7	-0.3	0.6	-0.9	-0.4	-1.7	-2.6
Food consumed during 24 hour testing period	0.5	1.0	1.8	0.8	1.2	-1.1	0.5	-1.3	-0.8
Glucose	0.0	0.1	0.2	-0.1	0.1	-0.1	0.1	-0.3	-0.4
Heart weight	0.3	0.5	1.1	-1.0	-0.7	0.8	-0.6	0.6	-0.3
Delay discount hyperbolic model param	1.0	1.3	3.8	-0.7	-0.6	0.4	-1.7	-0.2	-2.0
Intermittent access intake day 1-15 change	0.4	2.3	3.5	1.9	1.6	-1.1	1.6	-0.5	1.9
Intermittent access intake escalation	0.3	1.4	2.9	1.4	1.1	-0.7	1.2	-0.2	1.7
Intermittent access intake escalation 2	0.7	1.2	2.1	1.4	1.2	-0.8	1.1	-0.4	1.4
Intermitt. access day 1 inactive lever presses	0.1	0.7	1.2	0.7	0.9	-1.0	0.3	-1.1	-0.7
Intermitt. access day 15 inactive lever presses	0.1	0.7	1.3	-0.6	-0.6	1.1	-0.7	1.1	0.5
Intermitt. access escalation Index	1.5	4.7	7.3	-2.5	-2.7	2.2	-2.1	2.1	-0.9
Intermittent access day 1 total infusions	0.1	0.4	1.3	0.4	0.3	-0.3	1.1	-0.0	0.8
Intermittent access day 15 total infusions	0.6	1.5	4.1	1.2	0.9	-0.5	1.5	0.2	2.0
Intermittent access terminal intake (last 3 days)	0.5	0.9	3.2	0.9	0.5	-0.2	1.0	0.4	1.8
Intermittent access total infusions	0.4	0.5	1.8	0.2	0.0	0.3	0.9	0.7	1.3
Intermittent access day 1 locomotion	0.2	0.4	1.3	0.6	0.6	-0.5	1.1	-0.3	0.5
Intermittent access day 15 total locomotion	0.3	1.1	2.2	1.0	1.1	-1.0	1.5	-0.8	0.7
Intermittent access total locomotion	1.2	1.5	2.8	1.3	1.4	-1.1	1.7	-0.8	0.9
Intermittent access standard deviation	0.6	3.0	6.1	1.9	1.7	-1.1	2.0	-0.4	2.5
Left kidney weight	0.5	3.7	5.2	-2.3	-2.2	2.2	-1.5	2.3	-0.2
Right kidney weight	0.2	1.1	2.2	-1.3	-1.2	1.1	0.1	1.5	0.5
Cocaine induced anxiety	0.0	0.1	0.3	-0.3	-0.1	-0.0	-0.2	-0.1	-0.6
Post-drug Anxiety	0.2	0.2	0.9	-0.2	0.2	-0.2	-0.1	-0.4	-1.0
Baseline Anxiety	0.1	0.2	0.3	0.5	0.4	-0.3	0.5	-0.3	0.0
Tail length	0.8	4.3	6.8	-2.3	-2.4	2.4	-1.4	2.6	0.5
Length with tail	0.3	1.5	2.8	-1.7	-1.2	1.4	-0.8	1.3	-0.6
Length without tail	0.3	1.4	2.6	0.9	1.6	-1.2	1.5	-1.2	-0.2
Times rat made contact with spout	2.5	2.9	4.3	-1.7	-1.8	1.7	-2.1	1.0	-1.7
Lifetime Intake	0.3	0.4	1.1	0.4	0.3	-0.1	1.0	0.3	1.0
Liver weight, left	0.1	0.2	0.5	-0.7	0.1	0.2	0.7	0.2	0.2
Liver weight, right	0.8	1.4	2.5	0.7	1.6	-1.2	1.3	-1.3	-0.5
Locomotor activity	2.8	4.4	7.2	-2.7	-2.3	2.5	-1.4	2.4	-0.3
Locomotor testing distance	1.1	2.7	4.6	-2.2	-1.7	1.8	-1.5	1.6	-0.7
Locomotor testing rearing	0.1	0.3	0.8	-0.9	-0.5	0.5	-0.0	0.5	0.2
Locomotion in novel chamber	0.1	0.1	0.3	0.1	-0.2	0.0	0.1	0.3	0.6
Locomotion in novel chamber post-restriction	0.1	0.2	0.7	0.4	0.2	-0.6	0.0	-0.8	-0.4
Fecal boli incidents, locomotor time 1	0.9	2.4	4.9	-2.2	-1.4	1.2	-1.3	0.7	-2.0
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.0	0.2	-0.0	0.3	0.2	0.4
Time >=10cm from walls, locomotor time 1	0.6	0.7	1.1	-1.1	-0.8	1.0	-0.7	0.6	-0.8
Bouts of movement, locomotor time 1	0.2	0.3	0.5	-0.5	-0.7	0.6	-0.1	0.6	-0.1
Total resting periods, locomotor time 1	0.2	0.3	0.6	-0.5	-0.8	0.6	-0.1	0.6	-0.3
Rest time, locomotor task time 1	0.2	0.3	1.4	0.2	0.4	-0.5	1.2	-0.3	-0.1
Distance moved, locomotor task time 1	0.1	0.4	1.5	-0.2	-0.4	0.2	-1.2	-0.2	-0.7
Vertical activity count, locomotor time 1	0.0	0.3	1.0	-0.4	-0.5	0.3	-1.0	0.1	-0.5
Time >=10cm from walls, locomotor time 2	0.6	1.8	2.9	-0.8	-1.4	1.7	-1.3	1.7	0.7
Bouts of movement, locomotor time 2	0.4	1.4	4.0	1.1	0.7	-0.4	1.6	0.4	2.0
Total resting periods, locomotor time 2	0.4	1.7	3.9	1.3	0.9	-0.6	1.8	0.2	2.0
Rest time, locomotor task time 2	1.2	2.1	4.0	1.2	1.5	-1.6	2.0	-1.5	-0.0
Distance moved, locomotor task time 2	0.6	0.8	1.9	-0.4	-1.0	1.1	-1.4	0.9	0.1
Vertical activity count, locomotor time 2	0.3	0.7	2.2	-0.5	-0.8	0.8	-1.5	0.5	-0.4
Light reinforcement 1	0.1	0.4	1.2	-0.3	-0.0	0.3	1.1	0.6	0.7
Light reinforcement 2	0.6	1.4	3.6	1.0	0.8	-0.8	1.9	-0.3	1.5
Bone: marrow area	0.9	2.1	4.0	-2.0	-1.4	1.6	-1.1	1.1	-1.3
Bone: maximum diameter	2.2	4.5	6.7	-2.6	-2.2	2.2	-2.4	1.5	-1.7
Bone: maximum force	0.7	1.3	5.0	-0.4	0.5	-0.6	-0.5	-1.4	-2.2
Bone: maximum moment	0.6	1.2	4.8	-0.6	0.3	-0.3	-0.6	-1.1	-2.2
Mean time between licks in bursts	0.1	0.7	1.2	-0.8	-0.6	0.7	0.4	1.0	1.1
Mean num. licks in bursts	0.5	1.2	4.5	-1.0	-0.3	0.3	-1.3	-0.3	-2.1
Cd content in liver	2.8	3.1	4.5	1.7	2.1	-2.1	1.6	-2.1	-0.1
Co content in liver	0.9	1.0	1.8	0.6	1.0	-1.2	1.0	-1.4	-0.7
Cu content in liver	0.6	0.7	2.1	0.3	0.4	-0.3	1.5	0.1	1.3
Fe content in liver	0.4	0.5	0.8	-0.9	-0.7	0.7	-0.4	0.8	-0.2
K content in liver	1.8	1.8	3.0	1.7	1.5	-1.6	0.5	-1.7	-0.3
Mg content in liver	4.3	4.7	6.7	2.4	2.5	-2.6	1.8	-2.5	0.0
Mn content in liver	0.6	0.6	2.7	0.7	-0.1	0.3	0.1	0.7	1.6
Na content in liver	0.1	0.1	0.4	0.6	0.0	-0.2	-0.6	-0.4	-0.2
Rb content in liver	3.1	3.6	6.4	1.9	2.0	-1.9	2.5	-1.4	1.4
Se content in liver	0.7	0.9	1.6	0.9	1.3	-1.1	0.6	-1.1	-0.1
Sr content in liver	1.0	0.9	1.7	-1.3	-0.8	1.0	-0.9	0.8	-0.6
Zn content in liver	2.7	3.1	4.6	1.8	1.9	-1.7	2.2	-1.3	1.5
Bone: minimum diameter	0.0	0.0	0.2	-0.4	-0.0	0.0	0.3	-0.1	-0.2
Time in familiar zone, hab. session 1	0.1	0.2	0.5	-0.7	-0.2	0.3	-0.1	0.1	-0.5
Time in novel zone, hab. session 1	1.0	1.1	3.2	0.0	-0.8	0.9	-0.1	1.5	1.8
Total zone transitions, hab. session 1	1.1	1.5	3.2	0.1	1.3	-1.1	0.5	-1.6	-1.8
Total locomotion distance, hab. session 1	0.5	0.8	3.3	-0.8	0.0	0.2	-0.7	-0.4	-1.8
Locomotion velocity, hab. session 1	0.6	0.8	3.7	-0.5	0.3	-0.0	-0.5	-0.8	-1.9
Time in familiar zone, hab. session 2	0.3	0.4	0.7	-0.3	-0.8	0.7	-0.7	0.7	0.1
Time in novel zone, hab. session 2	0.7	0.8	1.6	0.5	1.2	-0.9	1.0	-0.9	0.0
Total zone transitions, hab. session 2	2.1	2.7	6.4	-2.2	-0.9	0.9	-1.8	0.1	-2.5
Total locomotion distance, hab. session 2	3.4	4.5	7.3	-2.7	-1.8	2.0	-2.4	1.1	-2.3
Locomotion velocity, hab. session 2	3.5	4.7	7.6	-2.8	-1.9	2.0	-2.4	1.1	-2.3
Novel to familiar place preference ratio	0.6	0.8	2.5	1.4	0.4	-0.4	0.6	-0.1	1.6
Novelty place preference	0.5	0.7	2.4	1.1	0.1	-0.2	0.6	0.1	1.6
Time in novel zone, NPP test	0.6	0.8	3.0	1.0	0.2	-0.1	0.7	0.2	1.7
Total zone transitions, NPP test	0.8	1.2	4.7	-1.0	-0.2	0.3	-1.0	-0.4	-2.2
Total locomotion distance, NPP test	0.6	0.9	3.0	-0.8	-0.4	0.5	-1.1	-0.2	-1.7
Locomotion velocity, NPP test	0.6	0.8	2.9	-0.7	-0.4	0.3	-1.0	-0.3	-1.7
Intraocular pressure	1.2	1.9	6.1	0.8	1.0	-0.6	1.8	0.3	2.5
Delta distance traveled before/after self-admin	0.5	0.6	0.9	0.9	0.5	-0.8	0.9	-0.4	0.8
Delta ambulatory time before/after self-admin	0.3	0.6	0.9	0.9	0.6	-0.9	0.8	-0.6	0.6
Parametrial fat weight	0.0	0.1	0.3	-0.4	-0.5	0.2	0.4	0.2	0.0
Pavlov. Cond. lever latency	0.9	1.1	4.0	1.0	0.4	-0.2	1.1	0.4	2.0
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	0.2	0.4	-0.6	0.8	-0.5	0.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	-0.5	-0.1	0.1	0.6	0.3	0.4
Pavlov. Cond. index score	0.1	0.1	0.4	-0.6	-0.3	0.1	-0.3	-0.0	-0.6
Pavlov. Cond. latency score	0.3	0.4	1.4	-0.7	-0.2	0.1	-0.6	-0.3	-1.2
Pavlov. Cond. lever contacts	0.4	0.5	1.9	-0.7	-0.3	0.1	-0.8	-0.3	-1.4
Pavlov. Cond. magazine entry number	0.2	0.2	0.7	0.8	0.4	-0.5	-0.1	-0.5	0.1
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	-0.1	0.2	-0.2	-0.3	-0.2	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.2	-0.5	-0.2	0.1	0.0	0.1	-0.1
Pavlov. Cond. response bias	0.1	0.2	0.5	-0.7	-0.2	0.2	-0.1	0.1	-0.6
Pavlov. Cond. lever latency	5.0	7.1	9.9	-2.9	-3.1	3.2	-2.1	3.1	0.3
Pavlov. Cond. magazine entry latency	2.0	2.9	4.6	1.5	1.9	-2.0	1.4	-2.1	-0.8
Pavlov. Cond. change in total contacts	3.4	8.3	12.8	2.7	3.3	-3.5	2.4	-3.6	-1.0
Pavlov. Cond. index score	3.8	6.0	8.4	2.5	2.8	-2.9	2.1	-2.9	-0.5
Pavlov. Cond. latency score	3.2	5.1	7.4	2.4	2.6	-2.7	1.9	-2.7	-0.5
Pavlov. Cond. lever contacts	4.7	6.9	9.5	3.0	3.1	-3.1	2.2	-3.0	-0.1
Pavlov. Cond. magazine entry number	5.0	6.4	9.1	-2.4	-3.0	3.0	-2.5	2.9	0.2
Pavlov. Cond. intertrial magazine entries	0.3	0.6	1.2	-0.7	-0.8	0.9	-0.3	1.1	0.8
Pavlov. Cond. lever-magazine prob. diff.	4.2	6.5	9.0	2.6	2.9	-3.0	2.3	-3.0	-0.5
Pavlov. Cond. response bias	6.9	9.6	13.5	3.3	3.7	-3.7	2.7	-3.5	-0.3
Time in closed arm before self-admin	0.3	0.5	1.3	0.4	0.2	-0.2	1.1	0.2	1.1
Time in closed arm after self-admin	1.1	1.2	3.5	-0.1	-0.5	0.7	1.1	1.3	1.9
Time in open arm before self-admin	0.1	0.1	0.2	-0.3	0.0	0.4	-0.5	0.4	0.1
Time in open arm after self-admin	0.4	0.5	1.5	-0.0	-0.0	0.1	-1.2	-0.4	-1.0
Bone: periosteal estimation	0.5	1.1	2.1	-1.4	-0.8	0.9	-1.0	0.3	-1.5
Bone: periosteal perimeter	0.9	1.8	2.8	-1.7	-1.1	1.3	-1.4	0.7	-1.5
Bone: post-yield work	0.1	0.2	0.5	0.1	0.4	-0.5	0.1	-0.7	-0.6
Progressive ratio test 1 active lever presses	0.4	0.8	1.4	0.6	0.6	-1.0	0.9	-1.2	-0.8
Progressive ratio test 1 breakpoint	0.4	0.7	1.2	0.6	0.6	-0.9	0.9	-1.1	-0.7
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.5	-0.6	-0.5	0.5	-0.2	0.3	-0.7
Progressive ratio test 2 active lever presses	0.7	0.9	2.2	1.0	1.0	-0.7	1.5	-0.5	0.9
Progressive ratio test 2 breakpoint	0.8	1.0	2.2	1.0	0.9	-0.6	1.5	-0.4	1.1
Progressive ratio test 2 inactive lever presses	0.3	1.0	1.7	-1.2	-1.0	1.3	-0.5	1.2	0.2
Incentive Sensitization - Responses	0.2	0.5	1.6	-0.1	-0.1	0.6	0.4	0.8	1.3
Incentive Sensitization - Breakpoint	0.2	0.5	1.9	-0.0	-0.1	0.5	0.5	0.8	1.4
Sum of active levers in priming session hrs 5-6	4.5	4.3	6.8	-2.3	-2.2	2.4	-1.7	2.6	-0.2
Progressive ratio	0.6	1.8	3.1	-1.3	-1.5	1.7	-1.2	1.7	0.2
Food seeking constrained by brief footshock	1.5	1.9	2.7	-1.6	-1.6	1.6	-1.2	1.2	-0.9
Seeking ratio, punishment vs. effort	0.2	0.5	1.0	0.5	0.5	-0.9	0.5	-1.0	-0.5
Retroperitoneal fat weight	0.4	1.9	3.9	-2.0	-1.4	1.6	-0.8	1.6	-0.1
Reaction time number correct	0.2	0.6	1.2	0.5	0.8	-1.0	1.1	-0.8	0.1
Reaction time mean minus median	0.1	0.6	0.9	0.8	0.9	-0.6	1.0	-0.2	0.9
Reaction time mean minus median AUC	0.3	1.7	2.8	1.7	1.5	-1.3	1.3	-1.0	0.9
Reaction time num false alarms	0.9	1.5	2.5	1.4	1.3	-1.4	0.7	-1.6	-0.6
Reaction time num false alarms AUC	0.6	1.3	2.2	1.3	1.2	-1.3	0.6	-1.5	-0.5
Reaction time trials correct on left	0.2	0.6	1.2	0.5	0.8	-1.0	1.1	-0.8	0.1
Reaction time trials on left	0.2	0.6	1.3	0.5	0.8	-1.0	1.1	-0.7	0.2
Reaction time mean	0.7	1.4	2.7	1.6	1.1	-1.1	1.2	-0.7	1.3
Reaction time mean AUC	0.7	1.6	3.2	1.8	1.2	-1.2	1.1	-0.8	1.2
Median of all reaction times	0.9	1.5	2.9	1.7	1.0	-1.1	1.2	-0.8	1.3
Reaction time omissions	0.9	1.5	4.7	1.3	0.9	-0.6	1.2	0.2	2.2
Reaction time false alarm rate	0.2	0.3	0.8	0.9	0.6	-0.5	0.1	-0.7	-0.2
Reaction time premature initiation rate	0.6	1.0	2.1	-0.6	-1.2	0.9	-1.5	1.0	0.4
Reaction time premature initiations	0.2	0.5	1.1	-0.4	-0.9	0.6	-1.0	0.6	0.2
Std. dev. reaction times	0.3	1.0	1.4	1.2	1.0	-0.8	1.1	-0.4	1.2
Reaction time trials completed	0.2	0.6	1.3	0.5	0.8	-1.0	1.1	-0.7	0.2
Reaction time trials AUC	0.1	0.5	1.0	0.4	0.7	-0.9	1.0	-0.8	0.0
Run reversals in cocaine runway, females	0.8	0.9	1.7	0.5	0.8	-1.3	0.8	-1.3	-0.6
Run reversals in cocaine runway, males	0.3	0.3	1.6	0.4	0.1	0.1	0.1	0.4	1.3
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.3	-0.0	0.4	0.2	0.4	0.3
Latency to leave start box in cocaine runway, F	0.2	0.3	0.7	0.5	0.8	-0.4	0.6	-0.6	-0.2
Latency to leave start box in cocaine runway, M	1.1	1.1	2.1	-1.0	-1.0	1.3	-0.3	1.4	0.8
Std. dev. time between licks in bursts	0.6	1.1	1.9	1.2	0.8	-0.7	1.3	-0.4	1.4
Total sessions with >9 infusions	0.5	0.6	1.3	0.9	0.7	-0.7	1.1	-0.4	0.8
Short access day 1 total inactive lever presses	0.7	1.4	2.1	-1.3	-1.3	1.4	-1.2	1.3	-0.2
Short access day 10 total inactive lever presses	0.0	0.1	0.4	0.0	0.4	-0.1	-0.2	-0.2	-0.7
Short access day 1 total infusions	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.2	0.4	-0.2
Short access day 10 total infusions	1.2	2.0	3.5	1.6	1.4	-1.4	1.9	-1.1	1.0
Short access total infusions	0.5	0.7	1.6	0.8	0.8	-0.8	1.3	-0.6	0.5
Short access day 1 locomotion	0.4	0.7	1.2	0.9	0.8	-0.6	1.0	-0.2	1.1
Short access day 10 total locomotion	1.5	6.1	9.2	3.0	2.9	-2.7	2.2	-2.4	1.1
Short access total locomotion	1.5	2.3	3.5	1.9	1.7	-1.7	1.5	-1.4	0.7
One hour access (0.3 mA shock)	0.9	1.0	3.6	1.0	0.6	-0.2	1.0	0.4	1.9
Compulsive drug intake	0.1	0.2	0.4	0.1	0.0	0.5	-0.2	0.5	0.6
One hour access (shock baseline)	0.1	0.4	1.6	0.3	-0.1	0.1	0.5	0.5	1.3
Social response proportion	0.2	0.2	0.5	0.0	-0.2	0.6	-0.2	0.7	0.6
Social responses	0.2	0.3	0.6	0.1	0.6	-0.4	0.5	-0.6	-0.8
Social time	0.0	0.1	0.4	0.1	-0.0	0.1	-0.6	0.0	0.0
Soleus weight	6.9	20.4	34.3	-4.4	-5.3	5.4	-2.9	5.9	1.9
Bone: stiffness	0.3	0.6	2.3	-0.4	0.0	-0.3	-0.5	-0.9	-1.5
Tibialis anterior weight	3.4	11.7	15.8	-3.4	-4.0	3.8	-4.0	3.3	-1.3
Time to tail flick, vehicle, before self-admin	0.8	1.0	4.0	-0.7	-0.3	-0.1	-0.9	-0.7	-2.0
Time to tail flick, vehicle, after self-admin	0.3	0.5	1.5	-1.2	-0.7	0.7	-0.2	0.6	-0.7
Time to tail flick, test, before self-admin	0.7	0.8	1.3	-1.0	-1.1	0.9	-1.1	0.7	-0.3
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.4	-0.1	0.3	0.4	0.3	0.3
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.5	-0.8	-0.8	1.1	-0.2	1.2	0.7
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.6	-0.3	0.6	0.0	0.6	0.1
Tibia length	0.1	0.2	0.8	-0.4	-0.3	0.2	0.3	0.4	0.9
Ambulatory time before self-admin	0.6	1.8	5.9	-1.2	-0.9	0.3	-1.6	-0.5	-2.4
Ambulatory time after self-admin	0.3	0.5	1.1	0.2	0.1	-0.8	-0.2	-1.1	-1.1
Bone: tissue strength	1.8	1.9	7.0	-1.2	-0.4	0.1	-1.4	-0.8	-2.6
Total heroin consumption	0.1	0.1	0.3	-0.0	0.4	0.1	0.5	0.4	0.3
Bone: trabecular number	1.7	3.3	5.7	-1.8	-1.8	1.7	-2.4	0.9	-1.9
Bone: trabecular spacing	0.5	0.8	1.4	0.7	0.7	-0.9	1.2	-0.6	1.0
Bone: trabecular thickness	0.2	0.2	0.8	-0.3	0.0	0.0	-0.6	-0.3	-0.9
Bone: trabecular tissue density	0.6	1.0	1.6	0.8	1.2	-1.3	1.0	-1.1	0.2
Water consumed over 24 hours	0.2	0.3	0.8	0.5	0.9	-0.4	0.8	-0.4	0.2
Number of responses in last shaping day	1.4	1.8	2.7	1.5	1.4	-1.6	0.9	-1.6	-0.1