Hub : Genes

Pelo

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Pelo	0.13	0.09	3.0e-03	0.1	0.06	0.06	0.07	3.4e-05	1.2e-03	1.6e-03	4.0e-04
2	Brain	gene expression	Pelo	0.05	0.03	2.4e-04	0.03	0.04	0.04	0.03	1.1e-03	2.3e-04	2.3e-04	3.4e-04
3	PL	gene expression	Pelo	0.06	0.03	1.2e-07	0.07	0.07	0.07	0.07	6.0e-08	5.4e-08	7.0e-08	9.3e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	3.1	5.2	7.5	-2.4	1.4	2.7
Area under the delay curve	0.4	0.4	1.2	0.3	-0.1	-1.1
BMI with tail	0.5	1.5	2.6	-1.6	0.3	1.4
BMI without tail	3.7	7.6	12.2	-3.5	2.0	2.6
Body weight	1.9	7.9	10.7	-2.9	2.2	3.3
Weight adjusted by age	0.2	0.2	0.4	0.6	0.4	0.1
Bone surface	1.2	2.2	4.5	-1.4	0.4	2.1
Bone volume	0.9	1.6	3.2	-1.2	0.2	1.8
Breakpoint value in progressive ratio session	0.1	0.2	0.2	0.5	0.5	-0.2
Number of licking bursts	0.1	0.1	0.2	-0.1	0.4	-0.3
Context. condit. distance diff. score	0.3	0.4	0.9	0.0	-0.9	0.5
Locomotion velocity, session 1	0.2	0.2	0.4	0.5	-0.6	-0.1
Locomotion distance, session 1	1.0	1.3	3.1	-0.8	-0.1	1.8
Locomotion velocity, session 2	0.9	1.0	2.1	-0.7	1.5	0.7
Locomotion distance, session 2	0.8	1.1	2.3	-1.0	0.1	1.5
Locomotion velocity, session 3	0.6	0.7	1.9	-0.2	1.4	0.1
Locomotion distance, session 3	0.0	0.0	0.0	0.1	0.2	0.1
Stereotopy head waving bouts, day 3	4.7	5.6	8.6	-2.4	2.9	1.6
Stereotopy head waving duration, day 3	2.2	2.7	5.1	-1.5	2.3	0.8
Locomotion velocity, session 7	0.1	0.1	0.2	0.2	-0.2	-0.5
Locomotion distance, session 7	0.7	0.9	1.7	0.8	-0.6	-1.3
Stereotopy head waving bouts, day 7	0.7	0.8	1.1	-0.9	1.0	0.7
Stereotopy head waving duration, day 7	1.2	1.4	1.9	-1.1	1.4	1.0
Locomotion velocity, session 8	0.9	1.1	1.7	1.3	-1.1	-0.6
Locomotion distance, session 8	0.7	1.0	2.0	0.1	-1.4	1.0
Degree of sensitization distance	0.5	0.5	0.7	0.7	-0.5	-0.9
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.6	0.4	0.4
Conditioned locomotion	0.5	0.6	0.9	-0.6	1.0	0.6
Cocaine response after cond. corrected	1.2	1.3	2.4	-1.6	0.7	1.0
Cocaine response after cond. not corrected	0.1	0.1	0.2	-0.4	-0.2	-0.3
Cocaine response before conditioning	5.9	7.1	8.5	2.8	-2.3	-2.9
Saline control response	0.1	0.2	0.3	0.6	-0.1	-0.4
Bone: connectivity density	3.2	5.1	7.0	-2.4	1.6	2.7
Bone: cortical apparent density	6.2	8.1	10.6	2.8	-2.5	-3.3
Bone: cortical area	0.1	0.1	0.2	-0.3	-0.3	0.5
Bone: cortical porosity	1.4	1.6	2.1	-1.3	1.0	1.4
Bone: cortical porosity	1.0	1.0	1.3	-1.2	0.7	1.1
Bone: cortical thickness	0.7	1.1	1.6	0.9	-1.3	-0.9
Bone: cortical thickness	2.3	2.7	3.9	1.6	-1.2	-2.0
Bone: cortical tissue density	5.9	7.8	10.3	2.7	-2.4	-3.2
Condit. Reinf. active minus inactive responses	1.4	1.6	2.1	1.2	-1.4	-1.1
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.0	1.3	-1.1	-1.4
Condit. Reinf. active responses	1.4	1.7	2.5	1.1	-1.6	-1.1
Condit. Reinf. inactive responses	0.6	0.7	1.7	0.5	-1.3	-0.4
Incentive salience index mean	0.3	0.4	1.1	0.3	-1.0	-0.1
Condit. Reinf. lever presses	0.5	0.7	1.1	-0.9	-0.5	1.1
Condit. Reinf. active minus inactive responses	2.4	3.0	3.9	2.0	-1.9	-1.2
Condit. Reinf. active-inactive response ratio	2.0	2.1	3.1	1.7	-1.7	-0.7
Condit. Reinf. active responses	0.5	0.8	1.1	1.0	-0.9	-0.7
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.1	0.2	-0.6
Condit. Reinf. lever presses	5.9	8.0	10.2	3.2	-3.0	-2.2
Condit. Reinf. lever reinforcers received	1.4	2.0	2.7	1.6	-1.4	-1.2
Conditioned reinforcement - actives	0.0	0.0	0.1	0.4	0.1	-0.1
Conditioned reinforcement - inactives	0.4	0.5	0.6	0.8	-0.6	-0.7
Conditioned locomotion	0.0	0.0	0.1	0.1	0.1	-0.3
Patch foraging indifference point 0 sec	1.7	2.8	4.0	1.9	-2.0	-1.0
Patch foraging indifference point AUC	0.4	0.5	0.8	-0.6	0.9	0.5
Delay disc. indifference point, 0s delay	0.2	0.2	0.5	0.4	0.3	-0.7
Delay disc. indifference point, 16s delay	0.3	0.3	0.6	0.2	-0.8	-0.6
Delay disc. indifference point, 2s delay	0.3	0.4	1.1	-0.0	1.0	0.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.4	0.3	0.2
Delay disc. indifference point, 4s delay	0.9	0.9	2.7	0.2	0.1	-1.6
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	-0.5	0.4	-0.4
Indifference point function ln k	0.8	1.1	1.2	0.9	-1.1	-1.0
Indifference point function log k	0.8	1.1	1.2	0.9	-1.1	-1.0
Patch foraging total patch changes 0 sec	1.4	2.2	3.0	1.7	-1.7	-1.0
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	-0.1	-0.1	0.2
Patch foraging total patch changes 18 sec	0.7	0.9	1.1	0.8	-1.1	-0.9
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.4	0.1	0.1
Patch foraging total patch changes 6 sec	0.1	0.2	0.3	0.4	-0.5	0.1
Patch foraging time to switch 0 sec	0.1	0.2	0.3	-0.5	-0.5	0.2
Patch foraging water rate 0 sec	0.3	0.4	0.7	0.0	0.9	-0.8
Patch foraging water rate 12 sec	1.4	2.2	3.7	-1.4	1.9	1.0
Patch foraging water rate 18 sec	0.1	0.2	0.5	-0.1	0.7	0.2
Patch foraging water rate 24 sec	0.0	0.0	0.0	0.1	-0.0	0.2
Patch foraging water rate 6 sec	0.3	0.4	1.0	0.4	0.1	-1.0
Seeking ratio, delayed vs. immediate footshock	1.2	1.3	1.9	-1.3	1.4	0.6
Distance traveled before self-admin	0.7	0.8	1.8	-0.7	-0.3	1.4
Distance traveled after self-admin	0.4	0.5	1.2	0.5	-1.1	-0.1
Extensor digitorum longus weight	2.5	9.8	13.5	-3.3	2.2	3.7
Bone: elastic displacement	0.3	0.3	0.4	-0.6	0.5	0.5
Bone: elastic work	0.0	0.0	0.0	-0.2	-0.0	0.1
Bone: endosteal estimation	0.9	1.9	2.6	-1.6	0.9	1.5
Bone: endosteal perimeter	1.8	3.7	5.6	-1.9	1.4	2.4
Epididymis fat weight	0.7	1.6	2.6	-1.6	1.2	0.9
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.5	0.5	-0.3
Delta time in open arm before/after self-admin	1.4	1.4	3.1	0.9	-1.7	-0.4
Diff in mean of infusions in LGA sessions	1.0	1.1	1.7	1.3	-0.5	-1.2
Delay discount exponential model param	0.4	0.4	1.2	-0.2	0.0	1.1
Extinction: sum of active levers before priming	0.4	0.4	1.2	-0.0	1.1	-0.1
Active lever presses in extinction session 6	0.2	0.2	0.6	-0.2	0.7	-0.1
Bone: final force	0.8	1.3	3.5	0.7	-1.9	-0.0
Bone: final moment	0.6	1.0	2.8	0.4	-1.7	0.2
Food consumed during 24 hour testing period	1.0	1.2	1.9	1.1	-1.4	-0.7
Glucose	0.0	0.0	0.0	0.2	-0.1	-0.2
Heart weight	0.4	0.6	0.8	-0.6	0.9	0.9
Delay discount hyperbolic model param	0.3	0.4	1.0	-0.2	-0.2	1.0
Intermittent access intake day 1-15 change	0.6	0.6	0.9	0.9	-0.1	-0.9
Intermittent access intake escalation	0.8	0.7	1.1	1.1	-0.1	-1.0
Intermittent access intake escalation 2	1.0	1.0	1.5	1.2	-0.4	-1.1
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.5	0.6	-0.7	0.2
Intermitt. access day 15 inactive lever presses	1.0	1.0	1.5	-1.2	1.0	0.7
Intermitt. access escalation Index	3.0	2.7	4.0	-1.4	1.4	2.0
Intermittent access day 1 total infusions	0.3	0.4	0.6	-0.6	0.8	0.4
Intermittent access day 15 total infusions	0.2	0.2	0.5	-0.1	0.7	-0.4
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.8	-0.2	0.9	-0.1
Intermittent access total infusions	0.5	0.5	1.1	-0.5	1.1	0.4
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.1	0.1	0.1
Intermittent access day 15 total locomotion	0.1	0.2	0.4	0.1	-0.0	-0.7
Intermittent access total locomotion	0.0	0.0	0.1	0.1	-0.1	-0.4
Intermittent access standard deviation	1.5	1.6	3.1	1.3	-0.2	-1.8
Left kidney weight	0.3	1.0	2.1	-0.5	1.4	0.8
Right kidney weight	0.2	0.6	1.6	0.2	1.2	0.4
Cocaine induced anxiety	0.1	0.1	0.4	0.6	-0.2	-0.2
Post-drug Anxiety	0.2	0.2	0.5	0.7	-0.2	-0.1
Baseline Anxiety	0.1	0.1	0.2	-0.4	0.2	0.1
Tail length	2.6	7.8	9.8	-2.7	3.1	2.5
Length with tail	1.6	5.7	8.1	-1.9	2.8	2.3
Length without tail	0.1	0.2	0.5	0.7	0.1	0.1
Times rat made contact with spout	1.7	2.0	3.3	-1.3	0.9	1.8
Lifetime Intake	0.1	0.1	0.4	-0.1	0.6	0.1
Liver weight, left	0.2	0.4	1.1	0.2	-0.1	-1.1
Liver weight, right	2.4	4.0	5.5	2.1	-2.3	-1.6
Locomotor activity	3.2	5.0	5.2	-2.2	2.3	2.2
Locomotor testing distance	1.8	3.0	3.7	-1.9	1.4	1.8
Locomotor testing rearing	0.3	0.5	0.9	-1.0	0.6	0.4
Locomotion in novel chamber	0.2	0.2	0.3	0.6	0.0	-0.5
Locomotion in novel chamber post-restriction	0.4	0.5	0.7	0.7	-0.8	-0.5
Fecal boli incidents, locomotor time 1	1.0	1.1	2.5	-0.7	0.5	1.6
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	-0.2	0.1	-0.1
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.1	-1.1	0.7	1.1
Bouts of movement, locomotor time 1	0.3	0.3	0.7	-0.8	0.5	0.2
Total resting periods, locomotor time 1	0.2	0.3	0.5	-0.7	0.4	0.2
Rest time, locomotor task time 1	0.2	0.2	0.3	0.5	-0.3	-0.6
Distance moved, locomotor task time 1	0.2	0.2	0.4	-0.5	-0.1	0.7
Vertical activity count, locomotor time 1	0.2	0.2	0.4	-0.5	0.2	0.6
Time >=10cm from walls, locomotor time 2	2.6	2.8	3.4	-1.8	1.8	1.3
Bouts of movement, locomotor time 2	0.5	0.6	1.1	0.6	0.4	-1.1
Total resting periods, locomotor time 2	0.7	0.7	1.7	0.7	0.2	-1.3
Rest time, locomotor task time 2	2.0	2.3	2.8	1.2	-1.6	-1.7
Distance moved, locomotor task time 2	0.7	0.9	1.0	-1.0	0.9	0.9
Vertical activity count, locomotor time 2	0.4	0.5	0.9	-0.5	0.6	0.9
Light reinforcement 1	0.1	0.2	0.2	0.3	0.5	-0.5
Light reinforcement 2	0.6	0.8	1.9	0.7	-0.2	-1.4
Bone: marrow area	0.9	2.0	2.8	-1.7	1.0	1.5
Bone: maximum diameter	2.6	4.7	6.7	-2.2	1.6	2.6
Bone: maximum force	0.5	0.8	2.3	0.3	-1.5	0.1
Bone: maximum moment	0.3	0.6	1.5	-0.0	-1.2	0.4
Mean time between licks in bursts	0.7	1.0	1.8	-1.4	1.1	0.3
Mean num. licks in bursts	0.5	0.6	1.5	-0.5	-0.3	1.2
Cd content in liver	4.9	5.3	6.6	2.2	-2.6	-2.2
Co content in liver	0.3	0.3	0.7	0.6	-0.8	-0.1
Cu content in liver	0.6	0.8	1.7	0.7	-0.3	-1.3
Fe content in liver	0.2	0.3	0.4	-0.6	0.7	0.2
K content in liver	0.7	0.6	1.0	1.0	-0.9	0.1
Mg content in liver	2.2	2.3	3.2	1.8	-1.6	-1.0
Mn content in liver	1.2	1.3	2.1	-1.1	1.4	0.8
Na content in liver	0.2	0.2	0.5	0.7	-0.4	0.1
Rb content in liver	1.5	1.9	2.9	1.4	-0.9	-1.7
Se content in liver	0.6	0.7	0.8	0.9	-0.9	-0.8
Sr content in liver	1.4	1.2	1.4	-1.1	1.1	1.2
Zn content in liver	4.3	4.7	5.3	2.3	-2.2	-2.1
Bone: minimum diameter	0.0	0.0	0.0	-0.2	-0.2	-0.2
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.4	0.1	0.5
Time in novel zone, hab. session 1	1.3	1.3	2.4	-1.2	1.5	0.1
Total zone transitions, hab. session 1	0.9	1.3	2.7	1.0	-1.6	-0.5
Total locomotion distance, hab. session 1	0.2	0.2	0.4	-0.2	-0.5	0.6
Locomotion velocity, hab. session 1	0.2	0.3	0.7	0.1	-0.8	0.4
Time in familiar zone, hab. session 2	0.4	0.4	0.4	-0.6	0.7	0.7
Time in novel zone, hab. session 2	0.7	0.6	0.7	0.7	-0.8	-0.9
Total zone transitions, hab. session 2	1.2	1.6	2.9	-1.3	0.0	1.7
Total locomotion distance, hab. session 2	2.9	3.8	5.9	-2.2	0.9	2.4
Locomotion velocity, hab. session 2	3.1	4.2	6.2	-2.3	1.0	2.5
Novel to familiar place preference ratio	0.4	0.4	1.3	0.1	-0.0	-1.2
Novelty place preference	0.3	0.3	1.0	0.0	0.2	-1.0
Time in novel zone, NPP test	0.4	0.4	1.1	-0.0	0.3	-1.1
Total zone transitions, NPP test	0.3	0.5	1.0	-0.4	-0.5	1.0
Total locomotion distance, NPP test	0.4	0.6	1.2	-0.8	-0.3	1.1
Locomotion velocity, NPP test	0.3	0.5	0.9	-0.6	-0.4	0.9
Intraocular pressure	0.8	1.1	2.7	0.6	0.5	-1.6
Delta distance traveled before/after self-admin	1.0	1.1	1.5	1.2	-0.8	-1.1
Delta ambulatory time before/after self-admin	0.8	0.9	1.2	1.1	-0.7	-1.0
Parametrial fat weight	0.0	0.1	0.2	-0.4	0.0	0.1
Pavlov. Cond. lever latency	0.4	0.5	1.3	0.4	0.3	-1.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.2	-0.2	-0.6
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.1	0.3	-0.3
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	-0.1	0.3
Pavlov. Cond. latency score	0.1	0.2	0.3	-0.2	-0.4	0.6
Pavlov. Cond. lever contacts	0.2	0.2	0.4	0.0	-0.6	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.4	-0.4	-0.3
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.0	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.1	0.1	0.1
Pavlov. Cond. response bias	0.0	0.0	0.0	0.2	-0.1	0.1
Pavlov. Cond. lever latency	7.1	9.6	11.4	-3.4	3.3	2.6
Pavlov. Cond. magazine entry latency	3.6	4.1	5.1	2.1	-2.3	-1.6
Pavlov. Cond. change in total contacts	8.3	11.4	14.0	3.6	-3.7	-2.7
Pavlov. Cond. index score	6.3	8.1	9.7	3.1	-2.9	-2.4
Pavlov. Cond. latency score	5.8	7.2	8.8	3.0	-2.8	-2.2
Pavlov. Cond. lever contacts	5.7	7.8	9.2	3.0	-2.8	-2.5
Pavlov. Cond. magazine entry number	7.4	9.0	10.7	-3.3	3.1	2.7
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.4	-0.9	1.2	0.6
Pavlov. Cond. lever-magazine prob. diff.	6.9	8.7	10.4	3.2	-3.1	-2.5
Pavlov. Cond. response bias	8.7	11.8	14.1	3.8	-3.5	-3.0
Time in closed arm before self-admin	0.2	0.2	0.4	0.2	0.4	-0.7
Time in closed arm after self-admin	1.0	1.0	2.3	-0.8	1.5	-0.0
Time in open arm before self-admin	0.2	0.2	0.5	-0.2	0.7	0.3
Time in open arm after self-admin	0.3	0.4	1.1	0.0	-1.0	0.1
Bone: periosteal estimation	0.4	0.8	1.3	-1.1	0.3	1.1
Bone: periosteal perimeter	1.1	1.9	2.9	-1.4	0.8	1.7
Bone: post-yield work	0.2	0.2	0.6	0.2	-0.7	-0.2
Progressive ratio test 1 active lever presses	0.6	0.6	1.1	0.8	-1.1	0.4
Progressive ratio test 1 breakpoint	0.6	0.6	0.9	0.8	-1.0	0.4
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.5	-0.7	0.7	1.2
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	-0.4	0.3	0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.1	-0.3	0.3	-0.2
Progressive ratio test 2 inactive lever presses	2.6	3.0	3.7	-1.8	1.9	1.4
Incentive Sensitization - Responses	1.2	1.2	2.2	-1.2	1.5	0.2
Incentive Sensitization - Breakpoint	1.1	1.1	1.9	-1.1	1.4	0.1
Sum of active levers in priming session hrs 5-6	4.5	4.4	8.3	-1.4	2.9	1.7
Progressive ratio	2.0	2.4	2.5	-1.6	1.6	1.5
Food seeking constrained by brief footshock	1.0	1.3	1.6	-0.9	1.1	1.3
Seeking ratio, punishment vs. effort	0.8	0.9	1.0	1.0	-1.0	-0.9
Retroperitoneal fat weight	0.9	3.0	4.4	-2.1	1.1	1.9
Reaction time number correct	1.0	1.5	3.1	1.7	-0.9	-0.8
Reaction time mean minus median	0.4	0.6	1.1	0.7	-0.2	-1.1
Reaction time mean minus median AUC	1.3	1.7	2.4	1.3	-1.0	-1.5
Reaction time num false alarms	1.7	2.3	3.4	1.8	-1.7	-0.9
Reaction time num false alarms AUC	1.6	2.1	3.2	1.8	-1.6	-0.8
Reaction time trials correct on left	1.0	1.5	3.1	1.7	-0.9	-0.8
Reaction time trials on left	1.0	1.5	3.0	1.7	-0.8	-0.8
Reaction time mean	0.7	1.0	2.4	0.4	-0.6	-1.5
Reaction time mean AUC	0.8	1.1	2.4	0.5	-0.8	-1.6
Median of all reaction times	0.6	0.9	2.1	0.2	-0.7	-1.4
Reaction time omissions	0.5	0.7	1.9	0.3	-0.0	-1.4
Reaction time false alarm rate	0.2	0.3	0.5	0.6	-0.7	-0.3
Reaction time premature initiation rate	0.8	1.1	1.3	-1.2	1.1	0.9
Reaction time premature initiations	0.2	0.2	0.4	-0.2	0.6	0.6
Std. dev. reaction times	0.6	0.8	2.0	0.6	-0.4	-1.4
Reaction time trials completed	1.0	1.5	3.0	1.7	-0.8	-0.8
Reaction time trials AUC	1.0	1.4	2.8	1.7	-0.9	-0.7
Run reversals in cocaine runway, females	1.5	1.4	1.9	1.2	-1.4	-1.0
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.4	0.5	-0.3
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.5	0.2	0.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.5	0.4	-0.7	-0.3
Latency to leave start box in cocaine runway, M	1.3	1.3	1.7	-1.3	1.3	0.7
Std. dev. time between licks in bursts	0.8	1.0	2.0	0.9	-0.4	-1.4
Total sessions with >9 infusions	0.1	0.1	0.1	0.3	0.3	0.0
Short access day 1 total inactive lever presses	3.5	3.9	5.0	-1.9	1.8	2.2
Short access day 10 total inactive lever presses	0.4	0.4	0.9	0.9	-0.5	-0.2
Short access day 1 total infusions	0.2	0.2	0.4	-0.3	0.6	0.3
Short access day 10 total infusions	0.3	0.4	0.7	0.9	-0.4	-0.5
Short access total infusions	0.1	0.1	0.2	0.5	-0.0	-0.1
Short access day 1 locomotion	0.2	0.2	0.5	0.2	0.4	-0.7
Short access day 10 total locomotion	1.9	2.1	2.9	1.3	-1.4	-1.7
Short access total locomotion	0.6	0.6	0.8	0.9	-0.6	-0.8
One hour access (0.3 mA shock)	0.1	0.2	0.4	0.1	0.4	-0.6
Compulsive drug intake	0.2	0.2	0.4	-0.3	-0.1	-0.6
One hour access (shock baseline)	0.1	0.1	0.1	0.2	0.4	-0.0
Social response proportion	0.3	0.3	0.5	-0.7	0.7	0.3
Social responses	0.4	0.5	0.9	1.0	-0.7	-0.4
Social time	0.1	0.1	0.2	-0.4	0.0	0.3
Soleus weight	8.4	24.7	34.7	-5.1	5.9	3.7
Bone: stiffness	0.2	0.3	1.0	0.2	-1.0	0.0
Tibialis anterior weight	3.9	13.5	15.5	-3.9	3.2	3.8
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.3	0.6	-1.2	0.5
Time to tail flick, vehicle, after self-admin	0.5	0.5	0.8	-0.4	0.9	0.9
Time to tail flick, test, before self-admin	1.0	1.0	1.2	-0.9	1.1	1.0
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.5	0.5	0.1
Delta time to tail flick, vehicle, before/after SA	1.9	1.9	3.4	-1.3	1.9	0.8
Delta time to tail flick, test, before/after SA	0.3	0.2	0.5	-0.7	0.4	0.3
Tibia length	0.1	0.2	0.5	-0.4	0.7	0.2
Ambulatory time before self-admin	1.1	1.2	2.4	-1.0	0.1	1.6
Ambulatory time after self-admin	0.2	0.2	0.6	0.3	-0.7	-0.2
Bone: tissue strength	0.8	0.8	1.5	-0.4	-0.8	1.2
Total heroin consumption	0.2	0.2	0.4	0.3	0.5	-0.7
Bone: trabecular number	1.9	3.0	4.8	-1.9	0.9	2.2
Bone: trabecular spacing	0.6	0.8	1.6	0.6	-0.5	-1.3
Bone: trabecular thickness	0.1	0.1	0.2	-0.1	-0.3	0.4
Bone: trabecular tissue density	1.5	2.1	2.8	1.7	-1.2	-1.4
Water consumed over 24 hours	0.5	0.6	0.9	0.9	-0.6	-0.9
Number of responses in last shaping day	2.1	2.1	3.0	1.7	-1.6	-0.9