Hub : Genes

Pdyn

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Pdyn 0.52 0.13 2.4e-12 0.36 0.4 0.4 0.38 2.1e-09 1.3e-10 1.6e-10 6.8e-10
2 IL gene expression Pdyn 0.6 0.13 4.6e-12 0.22 0.29 0.21 0.24 4.4e-06 1.4e-07 9.1e-06 1.7e-06
3 PL gene expression Pdyn 0.3 0.1 0.0e+00 0.39 0.4 0.39 0.39 1.2e-45 6.9e-47 1.8e-45 1.5e-45
4 BLA gene expression Pdyn 0.13 0.07 1.7e-07 0.14 0.11 0.13 0.12 7.9e-08 1.3e-06 3.6e-07 4.4e-07
5 Brain gene expression Pdyn 0.51 0.17 0.0e+00 0.47 0.48 0.48 0.48 2.8e-48 5.9e-50 7.7e-50 1.2e-49
6 NAcc intron excision ratio chr3_137365130_137366344 0.03 0.02 3.8e-04 0.03 0.02 0.02 0.02 1.0e-04 1.5e-04 1.2e-04 1.2e-04
7 IC gene expression Pdyn 0.69 0.01 0.0e+00 0.4 0.35 0.4 0.25 9.4e-18 2.0e-15 9.6e-18 6.4e-11
8 BLA mRNA stability Pdyn 0.05 0.04 8.1e-03 0.05 0.01 0.01 0.04 7.6e-04 5.4e-02 7.9e-02 2.5e-03
9 pVTA intron excision ratio chr3_137357486_137365070 0.04 0.03 1.6e-03 0.04 0.01 0.03 0.01 1.9e-04 4.3e-02 9.0e-04 4.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.61.11.80.81.11.11.11.10.41.0-1.4-1.1
Area under the delay curve0.60.71.3-0.8-0.7-0.8-0.9-0.9-0.3-0.91.20.9
BMI with tail0.20.50.60.70.80.80.70.80.70.8-0.7-0.7
BMI without tail2.36.97.52.72.62.62.62.62.72.7-2.5-2.5
Body weight3.113.715.63.93.73.73.93.73.73.7-3.4-3.5
Weight adjusted by age1.72.64.02.01.81.71.61.61.11.4-1.5-1.5
Bone surface0.61.21.41.11.21.21.11.10.71.1-1.2-1.1
Bone volume0.61.11.51.01.11.11.11.10.71.0-1.2-1.0
Breakpoint value in progressive ratio session2.22.73.81.81.61.61.41.61.91.6-1.7-1.4
Number of licking bursts0.20.30.4-0.6-0.6-0.6-0.4-0.6-0.4-0.60.30.6
Context. condit. distance diff. score0.00.10.20.20.20.20.00.2-0.10.2-0.4-0.2
Locomotion velocity, session 10.20.20.40.60.50.50.20.40.30.3-0.4-0.4
Locomotion distance, session 10.30.40.60.60.80.80.50.70.10.6-0.5-0.5
Locomotion velocity, session 20.00.00.1-0.2-0.1-0.0-0.2-0.0-0.3-0.00.20.0
Locomotion distance, session 21.92.63.21.51.71.71.61.81.21.7-1.6-1.6
Locomotion velocity, session 31.21.41.61.21.21.31.11.21.21.2-1.1-1.1
Locomotion distance, session 37.48.08.92.72.92.92.83.02.52.9-2.8-2.8
Stereotopy head waving bouts, day 31.21.41.9-0.9-1.1-1.1-1.2-1.3-0.9-1.41.41.3
Stereotopy head waving duration, day 31.11.31.9-0.9-1.1-1.1-1.2-1.3-0.8-1.31.41.3
Locomotion velocity, session 70.80.91.11.01.01.00.70.90.81.0-0.9-1.0
Locomotion distance, session 71.21.62.91.11.21.31.11.30.71.3-1.7-1.3
Stereotopy head waving bouts, day 70.20.30.60.70.50.50.50.40.80.4-0.2-0.4
Stereotopy head waving duration, day 70.00.00.20.30.20.20.10.10.40.00.1-0.1
Locomotion velocity, session 80.40.50.80.70.80.90.50.80.40.7-0.7-0.7
Locomotion distance, session 82.43.44.21.82.02.11.72.01.21.9-2.0-1.8
Degree of sensitization distance1.71.72.1-1.3-1.3-1.4-1.4-1.4-1.4-1.41.01.3
Degree of sensitization stereotypy1.82.02.91.51.41.41.41.31.71.3-1.2-1.3
Conditioned locomotion2.83.24.82.21.91.91.61.72.01.5-1.7-1.6
Cocaine response after cond. corrected0.10.10.2-0.3-0.3-0.3-0.4-0.3-0.4-0.30.30.4
Cocaine response after cond. not corrected0.10.10.2-0.4-0.3-0.3-0.4-0.4-0.4-0.30.40.4
Cocaine response before conditioning0.00.00.1-0.3-0.2-0.2-0.1-0.1-0.1-0.00.20.1
Saline control response6.18.210.63.23.03.02.62.83.22.7-2.4-2.7
Bone: connectivity density0.30.40.90.40.60.70.70.70.10.6-1.0-0.6
Bone: cortical apparent density1.01.31.81.01.01.01.31.11.21.2-1.3-1.1
Bone: cortical area3.35.15.72.32.32.32.22.22.42.2-2.2-2.2
Bone: cortical porosity0.00.00.0-0.1-0.2-0.2-0.1-0.20.2-0.10.10.1
Bone: cortical porosity0.20.20.50.40.30.30.40.40.70.4-0.4-0.4
Bone: cortical thickness1.52.52.81.51.61.61.61.61.61.6-1.7-1.6
Bone: cortical thickness0.30.40.50.50.60.60.60.70.60.6-0.7-0.7
Bone: cortical tissue density0.71.01.40.90.80.81.11.01.11.0-1.2-1.0
Condit. Reinf. active minus inactive responses1.11.31.90.91.01.01.41.21.11.3-1.1-1.2
Condit. Reinf. active-inactive response ratio1.11.11.50.91.01.01.21.11.01.2-0.9-1.1
Condit. Reinf. active responses0.60.71.00.70.70.71.00.81.00.9-0.7-0.8
Condit. Reinf. inactive responses0.00.00.00.0-0.0-0.1-0.2-0.10.1-0.10.20.1
Incentive salience index mean0.40.50.80.60.60.60.90.70.90.8-0.7-0.7
Condit. Reinf. lever presses0.00.00.10.10.10.10.20.00.4-0.0-0.30.0
Condit. Reinf. active minus inactive responses3.34.34.42.02.12.12.02.12.12.1-1.9-2.1
Condit. Reinf. active-inactive response ratio3.03.53.91.81.81.81.91.92.01.8-1.9-1.9
Condit. Reinf. active responses5.07.07.42.62.72.72.62.72.52.7-2.6-2.7
Condit. Reinf. inactive responses0.70.91.21.11.11.10.81.00.61.0-0.9-1.0
Condit. Reinf. lever presses1.31.82.01.41.41.31.31.31.41.4-1.3-1.3
Condit. Reinf. lever reinforcers received3.85.25.52.32.32.42.22.32.22.3-2.2-2.3
Conditioned reinforcement - actives0.00.00.2-0.4-0.1-0.1-0.1-0.10.0-0.30.20.2
Conditioned reinforcement - inactives0.10.20.50.40.50.40.60.40.70.2-0.4-0.1
Conditioned locomotion0.40.50.9-0.7-0.4-0.5-0.9-0.7-0.1-0.80.90.7
Patch foraging indifference point 0 sec0.00.10.30.60.40.30.00.10.40.1-0.1-0.0
Patch foraging indifference point AUC0.91.31.71.11.01.11.21.21.01.3-1.1-1.3
Delay disc. indifference point, 0s delay3.43.74.5-1.9-1.9-1.9-2.1-2.0-1.2-2.02.12.0
Delay disc. indifference point, 16s delay0.80.81.3-0.9-0.9-0.9-1.0-0.9-0.3-0.91.10.9
Delay disc. indifference point, 2s delay0.20.20.3-0.3-0.4-0.4-0.4-0.5-0.1-0.40.60.5
Delay disc. indifference point, 24s delay2.32.64.2-1.8-1.6-1.6-1.5-1.5-2.0-1.51.61.5
Delay disc. indifference point, 4s delay0.00.00.10.00.0-0.0-0.1-0.10.2-0.20.30.1
Delay disc. indifference point, 8s delay0.80.91.5-1.0-0.8-0.9-1.0-0.9-0.4-1.01.21.0
Indifference point function ln k0.00.10.10.30.40.40.20.30.10.2-0.2-0.2
Indifference point function log k0.00.10.10.30.40.40.20.30.10.2-0.2-0.2
Patch foraging total patch changes 0 sec0.10.10.40.60.40.40.10.20.50.2-0.2-0.1
Patch foraging total patch changes 12 sec0.30.40.70.80.60.70.50.60.60.8-0.5-0.6
Patch foraging total patch changes 18 sec0.50.70.9-0.7-0.8-0.9-0.9-0.9-0.9-0.90.71.0
Patch foraging total patch changes 24 sec1.11.92.5-1.2-1.3-1.4-1.6-1.5-1.0-1.41.31.6
Patch foraging total patch changes 6 sec0.60.91.41.21.01.00.90.91.20.9-0.7-0.9
Patch foraging time to switch 0 sec1.63.34.2-2.0-2.0-2.0-1.8-1.8-1.6-1.61.71.8
Patch foraging water rate 0 sec3.57.39.13.02.92.82.72.62.62.4-2.7-2.5
Patch foraging water rate 12 sec0.20.40.60.70.80.70.70.70.30.5-0.8-0.4
Patch foraging water rate 18 sec0.50.70.90.80.90.91.00.90.80.8-0.6-0.8
Patch foraging water rate 24 sec0.60.81.30.90.90.90.90.90.60.9-1.1-0.9
Patch foraging water rate 6 sec2.02.93.41.91.71.71.71.61.51.7-1.8-1.6
Seeking ratio, delayed vs. immediate footshock0.10.10.6-0.4-0.4-0.4-0.4-0.3-0.8-0.1-0.20.1
Distance traveled before self-admin3.44.56.62.42.32.21.92.02.61.9-1.8-1.9
Distance traveled after self-admin1.41.72.51.61.51.51.21.31.01.3-1.1-1.2
Extensor digitorum longus weight0.00.20.30.50.40.50.50.40.30.4-0.3-0.4
Bone: elastic displacement0.00.00.1-0.20.00.00.20.20.10.3-0.2-0.3
Bone: elastic work0.00.00.1-0.00.10.10.30.20.10.3-0.3-0.3
Bone: endosteal estimation0.51.01.71.31.11.01.00.91.20.8-0.8-0.7
Bone: endosteal perimeter2.24.76.12.52.22.22.02.12.32.1-1.9-2.0
Epididymis fat weight0.10.20.5-0.1-0.4-0.3-0.2-0.4-0.7-0.50.40.6
Delta time in closed arm before/after self-admin0.70.60.8-0.9-0.8-0.8-0.5-0.8-0.9-0.90.80.7
Delta time in open arm before/after self-admin1.00.91.41.21.11.10.71.00.31.1-1.1-0.8
Diff in mean of infusions in LGA sessions0.30.40.80.70.30.40.70.50.00.9-0.6-0.8
Delay discount exponential model param0.60.61.20.80.70.80.90.80.40.8-1.1-0.8
Extinction: sum of active levers before priming1.21.41.71.31.11.11.11.11.01.3-1.2-1.3
Active lever presses in extinction session 60.10.10.4-0.1-0.1-0.1-0.6-0.20.4-0.10.40.2
Bone: final force3.14.96.22.32.22.22.12.12.52.1-2.2-2.1
Bone: final moment2.33.74.72.01.91.91.91.92.21.8-1.9-1.8
Food consumed during 24 hour testing period1.11.52.4-1.1-1.1-1.2-1.3-1.2-1.1-1.31.61.2
Glucose0.10.10.20.40.40.40.20.30.30.2-0.4-0.2
Heart weight3.65.66.42.52.42.52.32.42.02.4-2.5-2.3
Delay discount hyperbolic model param0.60.71.30.70.70.80.90.80.40.9-1.1-0.9
Intermittent access intake day 1-15 change0.00.10.40.20.30.30.20.20.60.0-0.1-0.0
Intermittent access intake escalation0.00.10.30.10.30.30.20.20.50.0-0.1-0.0
Intermittent access intake escalation 20.00.00.10.10.30.30.10.30.20.2-0.2-0.2
Intermitt. access day 1 inactive lever presses0.10.51.30.60.80.80.30.61.20.5-0.6-0.5
Intermitt. access day 15 inactive lever presses0.10.20.5-0.3-0.2-0.3-0.6-0.50.3-0.70.30.7
Intermitt. access escalation Index0.50.61.10.50.70.80.91.00.51.0-0.6-1.0
Intermittent access day 1 total infusions0.00.00.1-0.2-0.1-0.1-0.1-0.10.1-0.20.30.2
Intermittent access day 15 total infusions0.00.10.3-0.00.30.20.10.20.6-0.00.00.0
Intermittent access terminal intake (last 3 days)0.00.10.40.10.30.30.10.20.60.0-0.1-0.0
Intermittent access total infusions0.00.00.2-0.00.20.20.10.10.5-0.0-0.0-0.0
Intermittent access day 1 locomotion0.10.10.3-0.5-0.1-0.1-0.4-0.1-0.1-0.30.50.3
Intermittent access day 15 total locomotion0.00.10.20.10.30.2-0.2-0.00.4-0.30.10.2
Intermittent access total locomotion0.10.10.20.10.40.3-0.00.20.5-0.1-0.0-0.0
Intermittent access standard deviation0.10.20.60.50.50.40.50.40.80.3-0.2-0.3
Left kidney weight0.00.10.30.50.20.10.1-0.10.5-0.2-0.10.2
Right kidney weight0.00.10.40.60.20.20.20.10.40.1-0.3-0.1
Cocaine induced anxiety3.85.46.0-2.3-2.4-2.4-2.4-2.4-2.0-2.42.12.4
Post-drug Anxiety2.82.93.3-1.7-1.8-1.8-1.7-1.7-1.6-1.71.71.7
Baseline Anxiety0.20.20.30.40.50.50.50.60.30.6-0.1-0.6
Tail length3.714.318.04.13.83.73.93.64.23.6-3.5-3.5
Length with tail5.322.927.55.24.94.85.04.75.04.6-4.5-4.3
Length without tail2.06.48.42.92.62.62.72.52.42.3-2.4-2.2
Times rat made contact with spout0.00.00.10.0-0.0-0.0-0.1-0.1-0.2-0.30.30.3
Lifetime Intake0.10.10.30.20.40.30.20.20.50.1-0.2-0.1
Liver weight, left0.61.01.51.21.01.00.90.91.10.8-1.0-0.9
Liver weight, right0.20.30.50.60.50.50.50.40.70.5-0.6-0.5
Locomotor activity0.40.61.00.50.70.70.60.90.31.0-0.9-0.9
Locomotor testing distance0.00.00.1-0.2-0.1-0.1-0.2-0.0-0.30.1-0.00.0
Locomotor testing rearing0.30.60.80.80.80.80.70.80.50.9-0.8-0.8
Locomotion in novel chamber0.10.10.2-0.00.20.30.30.30.30.1-0.5-0.1
Locomotion in novel chamber post-restriction0.81.31.61.11.21.21.11.30.81.2-1.2-1.2
Fecal boli incidents, locomotor time 10.00.10.20.00.10.1-0.00.2-0.50.40.1-0.4
Change in fecal boli incidents, locomotor task0.20.20.9-0.3-0.3-0.3-0.3-0.4-0.9-0.60.10.7
Time >=10cm from walls, locomotor time 10.10.10.10.10.30.30.20.3-0.20.4-0.2-0.4
Bouts of movement, locomotor time 12.02.33.0-1.6-1.6-1.6-1.5-1.5-0.9-1.51.71.5
Total resting periods, locomotor time 11.41.62.0-1.4-1.4-1.4-1.2-1.3-0.8-1.21.41.2
Rest time, locomotor task time 10.10.10.2-0.5-0.5-0.5-0.1-0.3-0.1-0.20.30.2
Distance moved, locomotor task time 10.00.00.10.10.00.0-0.2-0.10.2-0.10.20.1
Vertical activity count, locomotor time 10.00.00.10.30.30.30.00.10.0-0.1-0.2-0.0
Time >=10cm from walls, locomotor time 20.00.00.1-0.1-0.1-0.1-0.2-0.10.3-0.10.10.1
Bouts of movement, locomotor time 20.40.71.0-1.0-0.8-0.8-0.6-0.80.5-0.80.90.9
Total resting periods, locomotor time 20.30.50.9-1.0-0.7-0.7-0.4-0.60.5-0.60.70.7
Rest time, locomotor task time 20.10.10.3-0.6-0.4-0.40.0-0.20.10.10.0-0.0
Distance moved, locomotor task time 20.00.00.20.1-0.0-0.0-0.2-0.20.1-0.4-0.00.3
Vertical activity count, locomotor time 20.10.10.40.60.40.40.30.20.6-0.1-0.3-0.1
Light reinforcement 10.61.41.91.21.11.11.21.11.41.2-1.0-1.0
Light reinforcement 20.50.81.21.10.90.81.00.80.70.9-1.0-0.7
Bone: marrow area0.40.91.61.31.01.00.90.91.20.8-0.8-0.7
Bone: maximum diameter4.27.98.93.02.92.82.72.82.92.7-2.8-2.7
Bone: maximum force0.81.42.01.31.21.21.11.11.41.1-1.2-1.0
Bone: maximum moment0.30.60.90.90.80.80.70.70.90.7-0.7-0.6
Mean time between licks in bursts0.00.00.1-0.2-0.2-0.2-0.2-0.2-0.0-0.20.10.3
Mean num. licks in bursts0.10.10.30.60.50.50.30.40.20.30.0-0.4
Cd content in liver2.73.13.41.61.71.71.81.81.81.9-1.7-1.8
Co content in liver2.73.23.71.81.81.81.81.81.81.7-1.9-1.7
Cu content in liver3.94.65.22.22.32.32.22.21.92.1-2.1-2.0
Fe content in liver0.10.20.30.20.40.40.40.40.40.4-0.5-0.4
K content in liver0.70.70.90.70.80.80.90.90.20.8-0.8-0.9
Mg content in liver4.14.24.62.02.12.12.12.11.72.1-2.1-2.1
Mn content in liver3.33.73.91.92.02.02.02.01.71.9-1.9-2.0
Na content in liver0.30.40.6-0.6-0.6-0.6-0.4-0.6-0.6-0.70.30.8
Rb content in liver5.36.17.02.52.52.62.52.52.02.4-2.6-2.4
Se content in liver1.61.92.31.21.31.31.51.51.11.5-1.4-1.5
Sr content in liver0.40.41.70.60.50.50.50.41.30.3-0.5-0.3
Zn content in liver1.51.71.91.41.31.31.41.31.41.2-1.2-1.2
Bone: minimum diameter1.52.83.41.81.71.71.61.61.81.5-1.5-1.5
Time in familiar zone, hab. session 11.11.02.2-1.1-0.9-0.9-0.9-0.8-1.3-0.81.50.8
Time in novel zone, hab. session 10.50.51.40.80.60.60.60.60.70.6-1.2-0.6
Total zone transitions, hab. session 10.30.50.70.50.70.70.80.80.30.8-0.5-0.8
Total locomotion distance, hab. session 10.10.20.30.30.40.40.50.5-0.10.50.0-0.5
Locomotion velocity, hab. session 10.10.20.30.30.50.50.60.50.10.5-0.1-0.5
Time in familiar zone, hab. session 21.31.41.7-1.2-1.1-1.1-1.2-1.1-1.2-1.11.31.2
Time in novel zone, hab. session 21.41.52.21.31.21.11.21.11.21.1-1.5-1.1
Total zone transitions, hab. session 22.83.54.11.81.92.02.02.01.72.0-1.6-1.9
Total locomotion distance, hab. session 20.70.91.10.91.01.01.01.10.71.0-0.8-0.9
Locomotion velocity, hab. session 20.30.40.50.60.70.70.70.70.40.6-0.5-0.6
Novel to familiar place preference ratio0.10.20.3-0.3-0.4-0.4-0.5-0.4-0.4-0.40.30.3
Novelty place preference0.30.40.6-0.5-0.6-0.6-0.7-0.6-0.6-0.60.50.5
Time in novel zone, NPP test0.20.20.3-0.4-0.4-0.4-0.6-0.5-0.4-0.50.30.4
Total zone transitions, NPP test0.20.30.40.40.50.50.60.60.30.6-0.3-0.6
Total locomotion distance, NPP test0.20.20.30.50.60.60.50.50.20.4-0.4-0.4
Locomotion velocity, NPP test0.00.00.10.10.20.20.20.2-0.10.1-0.1-0.1
Intraocular pressure0.00.00.20.10.20.20.00.10.50.20.2-0.2
Delta distance traveled before/after self-admin0.20.20.40.60.30.30.60.3-0.20.4-0.6-0.3
Delta ambulatory time before/after self-admin0.50.71.7-0.6-0.9-0.8-0.6-0.8-1.3-0.70.50.8
Parametrial fat weight0.20.50.6-0.7-0.8-0.8-0.7-0.7-0.8-0.60.60.7
Pavlov. Cond. lever latency0.20.20.30.60.50.50.50.50.50.5-0.2-0.5
Pavlov. Cond. magazine entry latency0.30.40.60.50.50.50.80.70.50.6-0.7-0.6
Pavlov. Cond. change in total contacts0.10.10.20.20.20.20.40.30.20.2-0.5-0.1
Pavlov. Cond. index score0.00.00.0-0.1-0.1-0.10.1-0.0-0.0-0.0-0.20.1
Pavlov. Cond. latency score0.10.10.2-0.4-0.3-0.3-0.1-0.2-0.3-0.30.00.3
Pavlov. Cond. lever contacts0.00.00.0-0.1-0.1-0.1-0.1-0.1-0.1-0.2-0.20.2
Pavlov. Cond. magazine entry number0.50.60.9-0.7-0.7-0.7-1.0-0.8-0.8-0.80.80.7
Pavlov. Cond. intertrial magazine entries0.20.30.40.50.60.60.50.60.40.6-0.2-0.6
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.1-0.0-0.10.20.00.10.0-0.10.0
Pavlov. Cond. response bias0.30.40.60.60.60.60.80.60.70.6-0.7-0.5
Pavlov. Cond. lever latency3.75.06.5-2.4-2.2-2.2-2.3-2.1-2.5-2.12.12.0
Pavlov. Cond. magazine entry latency0.00.00.10.10.0-0.0-0.1-0.10.1-0.20.20.3
Pavlov. Cond. change in total contacts2.43.94.92.22.01.92.01.92.21.8-1.8-1.8
Pavlov. Cond. index score2.33.14.12.01.81.81.81.72.01.6-1.6-1.5
Pavlov. Cond. latency score1.72.33.31.71.61.51.51.41.81.3-1.4-1.3
Pavlov. Cond. lever contacts3.14.35.62.22.12.02.12.02.41.9-1.9-1.9
Pavlov. Cond. magazine entry number0.50.60.9-0.9-0.8-0.8-0.7-0.7-1.0-0.60.60.6
Pavlov. Cond. intertrial magazine entries0.50.71.2-1.0-0.8-0.8-0.8-0.8-1.1-0.70.60.8
Pavlov. Cond. lever-magazine prob. diff.1.92.53.41.81.61.61.61.51.91.4-1.5-1.4
Pavlov. Cond. response bias3.24.45.82.42.22.12.12.02.41.9-1.9-1.8
Time in closed arm before self-admin0.30.40.7-0.6-0.7-0.7-0.8-0.6-0.6-0.40.70.6
Time in closed arm after self-admin1.11.21.7-1.2-1.2-1.2-0.8-1.1-1.3-1.01.00.9
Time in open arm before self-admin0.20.20.7-0.6-0.4-0.4-0.4-0.40.3-0.50.80.3
Time in open arm after self-admin0.40.40.70.80.80.80.30.60.50.6-0.5-0.5
Bone: periosteal estimation2.04.15.12.32.12.12.02.02.31.9-1.9-1.8
Bone: periosteal perimeter2.64.55.92.42.22.21.92.02.31.9-2.1-1.9
Bone: post-yield work1.11.62.3-1.0-1.1-1.2-1.4-1.3-0.8-1.41.51.4
Progressive ratio test 1 active lever presses1.41.82.11.11.41.31.31.41.51.3-1.3-1.4
Progressive ratio test 1 breakpoint1.61.92.21.21.41.41.41.41.51.4-1.3-1.4
Progressive ratio test 1 inactive lever presses0.10.20.50.20.50.50.30.50.70.4-0.2-0.4
Progressive ratio test 2 active lever presses0.20.20.40.50.60.60.50.50.40.3-0.5-0.4
Progressive ratio test 2 breakpoint0.30.30.50.50.70.60.60.60.50.4-0.6-0.5
Progressive ratio test 2 inactive lever presses0.40.61.00.81.00.90.60.71.00.5-0.6-0.5
Incentive Sensitization - Responses0.10.20.40.40.40.40.60.40.10.3-0.6-0.3
Incentive Sensitization - Breakpoint0.00.10.10.20.20.20.40.1-0.10.0-0.4-0.0
Sum of active levers in priming session hrs 5-60.70.71.21.10.80.80.60.70.80.8-0.9-0.7
Progressive ratio4.97.710.2-2.4-2.7-2.8-2.7-3.0-1.9-3.12.93.2
Food seeking constrained by brief footshock0.10.10.60.50.30.30.10.10.80.00.0-0.0
Seeking ratio, punishment vs. effort3.85.56.82.12.32.42.32.51.82.5-2.4-2.6
Retroperitoneal fat weight0.83.34.3-1.9-1.8-1.9-1.6-1.8-1.9-1.91.62.1
Reaction time number correct0.10.20.70.80.50.50.10.20.50.0-0.2-0.1
Reaction time mean minus median0.41.01.4-0.8-1.0-1.0-0.8-1.0-1.2-1.11.11.0
Reaction time mean minus median AUC0.20.50.8-0.6-0.6-0.7-0.5-0.7-0.9-0.80.70.7
Reaction time num false alarms1.62.32.71.61.61.61.51.51.31.3-1.4-1.6
Reaction time num false alarms AUC1.52.32.81.61.61.61.51.51.41.4-1.4-1.7
Reaction time trials correct on left0.10.20.70.80.50.50.10.20.50.0-0.2-0.1
Reaction time trials on left0.10.20.80.90.60.50.20.30.60.1-0.3-0.2
Reaction time mean0.00.00.2-0.1-0.1-0.10.1-0.0-0.4-0.0-0.1-0.1
Reaction time mean AUC0.00.00.2-0.2-0.1-0.10.1-0.0-0.4-0.0-0.1-0.1
Median of all reaction times0.00.10.10.00.20.20.30.3-0.20.3-0.4-0.4
Reaction time omissions1.11.62.41.11.21.21.31.30.91.2-1.5-1.4
Reaction time false alarm rate1.11.52.11.01.21.21.31.31.01.3-1.2-1.4
Reaction time premature initiation rate0.00.00.2-0.4-0.2-0.2-0.2-0.10.2-0.0-0.10.1
Reaction time premature initiations0.00.00.1-0.2-0.2-0.2-0.3-0.20.2-0.2-0.00.3
Std. dev. reaction times0.10.10.30.30.30.30.50.3-0.00.3-0.3-0.4
Reaction time trials completed0.10.20.80.90.60.50.20.30.60.1-0.3-0.2
Reaction time trials AUC0.10.30.90.90.60.60.20.30.60.2-0.4-0.2
Run reversals in cocaine runway, females0.10.10.3-0.10.10.10.50.10.40.0-0.40.1
Run reversals in cocaine runway, males1.71.72.41.01.31.31.11.41.01.5-1.6-1.5
Latency to leave start box in cocaine runway0.40.50.8-0.7-0.7-0.7-0.6-0.6-0.8-0.60.90.4
Latency to leave start box in cocaine runway, F1.01.12.2-1.2-1.1-1.0-1.0-0.8-1.2-0.81.50.6
Latency to leave start box in cocaine runway, M0.30.30.50.60.40.40.60.40.70.4-0.7-0.4
Std. dev. time between licks in bursts0.40.50.90.70.70.70.60.60.70.6-0.9-0.6
Total sessions with >9 infusions0.10.20.30.40.40.40.50.40.30.3-0.4-0.3
Short access day 1 total inactive lever presses2.33.04.8-2.2-1.6-1.7-1.6-1.6-1.4-1.81.81.8
Short access day 10 total inactive lever presses1.02.32.7-1.6-1.4-1.5-1.6-1.5-1.5-1.61.51.6
Short access day 1 total infusions0.10.20.4-0.4-0.2-0.3-0.4-0.3-0.6-0.40.40.4
Short access day 10 total infusions0.20.30.4-0.7-0.5-0.5-0.5-0.50.1-0.50.60.5
Short access total infusions0.00.00.00.10.10.10.10.1-0.00.0-0.1-0.0
Short access day 1 locomotion0.91.11.8-1.0-0.7-0.8-1.3-0.9-1.2-1.01.31.0
Short access day 10 total locomotion0.10.10.4-0.3-0.0-0.1-0.6-0.2-0.3-0.30.30.3
Short access total locomotion0.10.10.2-0.3-0.0-0.1-0.4-0.1-0.4-0.30.30.2
One hour access (0.3 mA shock)0.00.00.1-0.20.10.10.00.10.1-0.0-0.2-0.0
Compulsive drug intake1.41.72.6-1.6-1.2-1.3-1.4-1.2-1.3-1.31.01.3
One hour access (shock baseline)0.30.50.80.80.80.80.70.70.90.6-0.4-0.7
Social response proportion1.41.52.31.51.31.21.41.20.81.1-1.5-1.0
Social responses5.16.57.32.72.52.52.72.52.52.6-2.6-2.5
Social time0.40.60.70.70.80.80.70.80.50.7-0.7-0.9
Soleus weight0.00.00.10.20.20.20.20.2-0.00.2-0.3-0.1
Bone: stiffness2.03.34.52.01.81.71.71.72.11.7-1.9-1.7
Tibialis anterior weight1.44.65.52.02.12.12.22.22.12.4-1.9-2.3
Time to tail flick, vehicle, before self-admin1.51.62.6-1.1-1.2-1.2-1.3-1.3-0.9-1.41.11.6
Time to tail flick, vehicle, after self-admin0.91.21.4-1.0-1.1-1.1-0.9-1.1-1.1-1.11.21.2
Time to tail flick, test, before self-admin1.31.42.41.11.11.11.51.20.71.1-1.6-1.0
Time to tail flick, test, after self-admin0.30.30.5-0.5-0.5-0.6-0.6-0.6-0.7-0.70.30.6
Delta time to tail flick, vehicle, before/after SA2.01.92.41.51.41.41.41.41.31.4-1.1-1.4
Delta time to tail flick, test, before/after SA1.01.11.4-0.9-1.0-1.0-1.2-1.1-1.0-1.01.10.9
Tibia length4.712.814.23.73.63.73.53.63.83.6-3.1-3.6
Ambulatory time before self-admin2.03.04.91.91.91.81.51.62.21.5-1.4-1.5
Ambulatory time after self-admin2.32.74.32.11.71.81.61.61.41.6-1.5-1.5
Bone: tissue strength0.00.00.10.40.20.20.20.20.10.2-0.2-0.2
Total heroin consumption3.13.64.82.11.91.91.51.91.92.2-1.6-2.1
Bone: trabecular number1.11.82.81.11.41.41.41.40.91.3-1.7-1.4
Bone: trabecular spacing0.10.10.1-0.3-0.4-0.4-0.3-0.30.1-0.10.30.1
Bone: trabecular thickness0.70.81.20.81.01.01.01.00.50.8-1.1-1.0
Bone: trabecular tissue density1.72.62.81.71.61.61.51.61.71.5-1.6-1.6
Water consumed over 24 hours0.10.10.4-0.3-0.3-0.3-0.3-0.4-0.2-0.40.70.3
Number of responses in last shaping day0.00.00.10.20.30.20.10.2-0.20.20.1-0.2