Hub : Genes

Pds5b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC isoform ratio XM_039089328.1 0.28 0.14 3.5e-03 0.01 0.06 0.07 0.05 2.2e-01 1.3e-02 9.8e-03 2.7e-02
2 OFC isoform ratio XM_039089321.1 0.24 0.13 5.3e-03 0.03 0.05 0.06 0.05 5.6e-02 2.2e-02 1.7e-02 2.9e-02
3 PL gene expression Pds5b 0.5 0.14 0.0e+00 0.37 0.4 0.4 0.4 3.1e-42 4.9e-47 1.2e-46 1.3e-46
4 Brain mRNA stability Pds5b 0.09 0.05 3.3e-07 0.05 0.09 0.04 0.07 2.1e-05 2.6e-08 9.2e-05 4.0e-07
5 Brain gene expression Pds5b 0.52 0.13 0.0e+00 0.38 0.42 0.42 0.42 9.6e-38 8.6e-42 2.2e-42 1.4e-42
6 OFC intron excision ratio chr12_338727_341163 0.23 0.13 4.6e-03 0.04 0.05 0.05 0.06 3.2e-02 2.1e-02 2.2e-02 1.8e-02
7 NAcc gene expression Pds5b 0.4 0.13 0.0e+00 0.24 0.31 0.31 0.31 3.2e-27 5.6e-37 7.0e-37 5.9e-37
8 BLA gene expression Pds5b 0.45 0.14 3.9e-16 0.25 0.29 0.29 0.29 1.3e-13 1.1e-15 8.9e-16 6.2e-16
9 NAcc isoform ratio XM_039089328.1 0.05 0.03 1.1e-03 0.03 0.03 0.03 0.03 2.2e-04 4.5e-04 4.1e-04 6.6e-04
10 NAcc intron excision ratio chr12_338727_341163 0.03 0.02 8.7e-03 0.02 0 0.01 0.01 2.3e-03 1.3e-01 6.2e-03 1.2e-02
11 pVTA gene expression Pds5b 0.46 0.15 2.6e-12 0.27 0.24 0.25 0.26 3.6e-12 5.9e-11 3.6e-11 8.7e-12
12 IL gene expression Pds5b 0.56 0.15 2.1e-10 0.18 0.47 0.49 0.46 4.1e-05 1.0e-12 1.7e-13 2.0e-12
13 Adipose mRNA stability Pds5b 0.06 0.04 6.2e-04 0.01 0.02 0.03 0.02 9.7e-03 5.9e-03 8.2e-04 5.4e-03
14 OFC gene expression Pds5b 0.76 0.11 2.3e-14 0.37 0.41 0.45 0.41 1.3e-09 7.6e-11 4.8e-12 7.6e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.52.57.6-2.82.01.90.61.71.61.71.51.01.0-1.0-1.60.4-1.5
Area under the delay curve1.71.85.42.3-2.3-0.61.3-0.0-2.2-0.70.10.70.7-0.71.0-1.91.0
BMI with tail1.65.310.60.5-1.52.53.32.4-2.12.02.42.62.6-2.6-1.8-2.4-2.4
BMI without tail0.51.05.40.0-0.71.02.30.7-1.40.40.60.90.9-0.90.1-1.4-0.5
Body weight4.016.642.3-2.60.25.36.54.7-1.94.14.64.74.7-4.7-2.5-3.4-3.0
Weight adjusted by age0.50.62.5-1.61.40.6-0.40.41.30.60.40.00.0-0.0-0.60.8-0.6
Bone surface1.93.36.3-2.01.02.51.92.30.32.22.21.91.9-1.9-1.7-0.7-1.7
Bone volume1.72.95.4-1.91.12.31.22.10.72.22.11.71.7-1.7-1.9-0.3-1.8
Breakpoint value in progressive ratio session0.60.72.11.3-1.3-0.31.1-0.2-1.5-0.6-0.10.30.3-0.30.8-1.20.5
Number of licking bursts0.50.62.6-1.61.50.3-0.40.01.30.3-0.0-0.3-0.30.3-0.20.9-0.3
Context. condit. distance diff. score0.30.42.1-0.1-0.20.01.5-0.1-0.8-0.4-0.10.20.2-0.21.0-0.70.9
Locomotion velocity, session 10.50.51.31.1-0.9-0.8-0.1-0.9-0.7-0.9-0.8-0.6-0.60.60.7-0.40.5
Locomotion distance, session 10.81.11.81.0-0.5-1.3-1.1-1.3-0.1-1.2-1.3-1.1-1.11.11.10.31.0
Locomotion velocity, session 20.40.50.90.6-0.4-0.9-0.2-0.9-0.3-0.9-0.9-0.7-0.70.70.9-0.00.7
Locomotion distance, session 22.63.76.00.40.4-2.4-1.9-2.40.7-2.2-2.4-2.4-2.42.41.71.21.8
Locomotion velocity, session 30.10.10.20.4-0.4-0.10.4-0.1-0.5-0.3-0.10.00.0-0.00.2-0.5-0.0
Locomotion distance, session 30.50.51.0-0.70.9-0.6-1.0-0.61.0-0.4-0.6-0.8-0.80.80.21.00.1
Stereotopy head waving bouts, day 30.60.72.7-1.61.21.10.70.90.70.90.80.60.6-0.6-0.60.0-0.3
Stereotopy head waving duration, day 30.30.40.7-0.40.10.80.40.80.00.80.80.80.8-0.8-0.7-0.3-0.4
Locomotion velocity, session 71.11.24.62.1-2.0-0.41.0-0.2-1.9-0.6-0.10.40.4-0.40.7-1.50.3
Locomotion distance, session 71.01.22.61.2-0.8-1.5-0.0-1.4-0.8-1.6-1.3-1.0-1.01.01.5-0.31.1
Stereotopy head waving bouts, day 70.60.71.30.20.1-1.1-0.8-1.00.2-0.9-1.0-0.9-0.90.91.10.90.8
Stereotopy head waving duration, day 70.20.20.60.3-0.1-0.6-0.5-0.5-0.0-0.4-0.5-0.4-0.40.40.80.60.5
Locomotion velocity, session 80.30.41.10.9-1.00.10.9-0.0-1.1-0.10.00.30.3-0.30.5-1.10.7
Locomotion distance, session 80.20.30.80.3-0.4-0.10.9-0.3-0.8-0.5-0.20.00.0-0.00.8-0.80.8
Degree of sensitization distance0.80.82.01.4-1.1-1.10.1-0.9-1.0-1.1-0.9-0.6-0.60.61.1-0.40.9
Degree of sensitization stereotypy0.20.20.80.5-0.3-0.7-0.3-0.5-0.3-0.5-0.5-0.4-0.40.40.90.50.4
Conditioned locomotion0.20.20.5-0.70.60.5-0.30.40.60.60.40.20.2-0.2-0.40.4-0.3
Cocaine response after cond. corrected4.34.97.80.2-1.02.71.62.8-1.02.72.82.72.7-2.7-2.5-1.6-1.9
Cocaine response after cond. not corrected3.13.55.20.8-1.42.11.72.2-1.42.12.22.32.3-2.3-1.7-1.7-1.3
Cocaine response before conditioning1.51.84.50.7-0.4-1.6-0.1-1.7-0.6-1.8-1.7-1.3-1.31.32.10.21.5
Saline control response1.82.44.6-2.12.2-1.1-0.7-1.31.5-1.2-1.4-1.5-1.51.51.61.91.3
Bone: connectivity density1.01.66.1-2.51.71.71.11.31.11.31.20.90.9-0.9-1.0-0.1-0.8
Bone: cortical apparent density0.30.52.01.4-1.3-0.20.5-0.1-1.2-0.2-0.10.20.2-0.20.4-0.80.1
Bone: cortical area0.81.24.10.4-0.90.92.01.0-1.30.51.01.21.2-1.2-0.1-1.4-0.4
Bone: cortical porosity0.10.10.3-0.60.50.1-0.10.10.40.20.1-0.1-0.10.10.00.5-0.2
Bone: cortical porosity0.40.40.7-0.10.4-0.8-0.5-0.70.4-0.7-0.7-0.8-0.80.80.70.70.4
Bone: cortical thickness0.71.13.70.3-0.81.01.91.1-1.20.61.11.21.2-1.2-0.2-1.3-0.6
Bone: cortical thickness0.20.20.7-0.40.4-0.40.5-0.4-0.1-0.6-0.5-0.4-0.40.40.90.10.6
Bone: cortical tissue density0.30.41.71.3-1.2-0.20.4-0.1-1.0-0.2-0.10.20.2-0.20.4-0.70.1
Condit. Reinf. active minus inactive responses0.30.31.21.1-1.1-0.10.30.0-0.90.00.10.30.3-0.3-0.0-0.60.5
Condit. Reinf. active-inactive response ratio0.60.71.71.2-1.30.30.90.5-1.30.30.60.80.8-0.8-0.1-1.00.1
Condit. Reinf. active responses0.50.62.00.7-0.4-1.0-0.3-1.0-0.4-0.9-0.9-0.7-0.70.70.80.11.4
Condit. Reinf. inactive responses2.32.84.60.40.3-2.0-1.4-2.20.5-1.9-2.1-2.0-2.02.01.60.92.0
Incentive salience index mean0.30.30.60.8-0.6-0.8-0.3-0.7-0.4-0.7-0.7-0.5-0.50.50.60.00.8
Condit. Reinf. lever presses0.71.01.80.4-0.0-1.3-0.8-1.40.0-1.2-1.3-1.2-1.21.21.00.70.6
Condit. Reinf. active minus inactive responses0.60.72.40.5-0.5-0.91.1-0.8-1.0-1.2-0.8-0.4-0.40.41.6-0.61.0
Condit. Reinf. active-inactive response ratio0.80.92.00.9-0.8-1.00.8-0.9-1.0-1.3-0.9-0.5-0.50.51.4-0.61.2
Condit. Reinf. active responses0.71.03.50.5-0.6-1.01.1-0.9-1.1-1.4-0.9-0.5-0.50.51.9-0.51.2
Condit. Reinf. inactive responses0.10.20.7-0.30.3-0.40.1-0.40.0-0.5-0.4-0.3-0.30.30.80.20.4
Condit. Reinf. lever presses0.10.20.60.2-0.1-0.60.2-0.5-0.3-0.7-0.5-0.4-0.40.40.80.00.2
Condit. Reinf. lever reinforcers received0.91.34.30.7-0.6-1.30.9-1.2-1.0-1.6-1.2-0.8-0.80.82.1-0.41.4
Conditioned reinforcement - actives0.60.62.2-1.51.3-0.40.6-0.50.6-0.7-0.6-0.6-0.60.61.00.50.7
Conditioned reinforcement - inactives0.50.61.8-1.41.4-0.1-0.6-0.31.2-0.1-0.4-0.6-0.60.60.00.90.1
Conditioned locomotion0.40.41.4-1.21.0-0.30.6-0.30.4-0.6-0.4-0.5-0.50.51.00.20.9
Patch foraging indifference point 0 sec0.91.44.5-2.12.10.2-1.50.22.10.50.1-0.4-0.40.4-0.71.6-0.7
Patch foraging indifference point AUC0.40.51.2-1.11.1-0.4-0.3-0.60.8-0.5-0.6-0.7-0.70.70.50.80.4
Delay disc. indifference point, 0s delay7.68.314.82.4-3.12.33.32.8-3.21.92.93.53.5-3.5-1.4-3.8-1.3
Delay disc. indifference point, 16s delay0.60.61.31.1-1.0-1.00.2-0.5-0.9-1.0-0.5-0.1-0.10.11.1-0.51.0
Delay disc. indifference point, 2s delay2.93.210.43.2-3.20.11.80.5-2.9-0.00.61.21.2-1.20.1-2.7-0.1
Delay disc. indifference point, 24s delay0.50.41.21.1-1.0-0.60.2-0.4-0.9-0.6-0.4-0.1-0.10.10.7-0.51.1
Delay disc. indifference point, 4s delay2.32.45.52.2-2.30.31.51.1-2.10.21.21.71.7-1.70.0-2.30.1
Delay disc. indifference point, 8s delay0.91.02.61.2-1.0-1.30.1-0.8-0.9-1.3-0.7-0.4-0.40.41.6-0.51.6
Indifference point function ln k1.01.41.7-0.81.1-1.1-1.2-1.11.2-1.0-1.2-1.3-1.31.31.01.31.2
Indifference point function log k1.01.41.7-0.81.1-1.1-1.2-1.11.2-1.0-1.2-1.3-1.31.31.01.31.2
Patch foraging total patch changes 0 sec1.22.06.2-2.42.5-0.0-1.9-0.02.50.3-0.1-0.7-0.70.7-0.62.0-0.5
Patch foraging total patch changes 12 sec0.40.52.1-1.41.30.5-0.60.41.10.60.40.10.1-0.1-0.70.8-0.6
Patch foraging total patch changes 18 sec1.21.54.7-2.22.20.4-1.40.22.00.60.1-0.4-0.40.4-1.01.6-0.9
Patch foraging total patch changes 24 sec2.73.36.3-2.02.5-1.5-2.2-1.42.4-1.2-1.5-1.9-1.91.90.92.30.8
Patch foraging total patch changes 6 sec1.11.65.4-2.32.30.1-1.30.02.10.4-0.1-0.6-0.60.6-0.61.8-0.7
Patch foraging time to switch 0 sec7.010.814.32.7-3.53.12.73.3-3.13.03.53.83.8-3.8-3.0-3.5-2.9
Patch foraging water rate 0 sec4.57.215.6-3.63.9-1.7-2.3-2.03.5-1.6-2.2-2.7-2.72.71.73.41.8
Patch foraging water rate 12 sec2.43.74.8-1.52.0-1.9-1.7-1.91.9-1.8-2.0-2.2-2.22.21.82.11.9
Patch foraging water rate 18 sec2.43.35.20.00.6-2.3-1.1-2.20.6-2.2-2.2-2.1-2.12.12.21.22.0
Patch foraging water rate 24 sec1.62.33.5-1.81.9-1.1-0.6-1.41.5-1.3-1.5-1.6-1.61.61.61.71.6
Patch foraging water rate 6 sec1.21.72.3-1.21.5-1.0-1.0-1.31.5-1.1-1.3-1.5-1.51.51.11.41.1
Seeking ratio, delayed vs. immediate footshock0.50.52.1-0.20.50.2-1.40.21.00.50.2-0.1-0.10.1-1.30.6-1.2
Distance traveled before self-admin0.50.51.71.3-1.1-0.70.4-0.1-1.0-0.80.00.30.3-0.30.7-1.10.6
Distance traveled after self-admin0.50.62.10.20.1-1.1-0.3-0.70.1-1.1-0.7-0.6-0.60.61.20.11.4
Extensor digitorum longus weight0.41.57.9-1.90.91.42.81.1-0.30.71.01.11.1-1.10.1-0.7-0.1
Bone: elastic displacement0.10.10.5-0.70.60.30.10.40.50.20.30.20.2-0.2-0.30.1-0.3
Bone: elastic work0.50.73.0-1.71.30.90.80.90.70.70.80.60.6-0.6-0.20.2-0.6
Bone: endosteal estimation0.40.94.5-2.11.90.3-0.40.11.60.30.0-0.3-0.30.3-0.31.1-0.0
Bone: endosteal perimeter0.20.51.5-1.21.2-0.4-0.0-0.40.8-0.5-0.5-0.6-0.60.60.60.70.7
Epididymis fat weight0.10.20.80.3-0.60.20.90.4-0.80.10.40.60.6-0.60.2-0.50.0
Delta time in closed arm before/after self-admin0.40.40.80.5-0.4-0.50.3-0.9-0.4-0.7-0.9-0.7-0.70.70.70.00.5
Delta time in open arm before/after self-admin0.30.21.30.8-0.4-0.6-1.2-0.40.1-0.3-0.3-0.3-0.30.3-0.10.20.3
Diff in mean of infusions in LGA sessions0.91.02.0-0.10.4-1.0-0.5-1.40.3-1.1-1.4-1.4-1.41.41.00.90.4
Delay discount exponential model param1.71.75.5-2.32.21.0-1.00.42.11.10.3-0.2-0.20.2-1.41.6-1.3
Extinction: sum of active levers before priming0.80.81.51.1-0.7-1.1-0.5-1.2-0.4-1.0-1.2-1.0-1.01.00.80.20.6
Active lever presses in extinction session 60.10.10.3-0.10.1-0.1-0.0-0.50.1-0.2-0.5-0.6-0.60.60.10.4-0.3
Bone: final force0.40.62.9-0.60.10.91.70.9-0.50.50.80.90.9-0.90.1-0.7-0.3
Bone: final moment0.40.62.3-0.60.10.91.50.9-0.40.60.90.90.9-0.9-0.1-0.6-0.5
Food consumed during 24 hour testing period0.40.51.8-1.41.30.4-0.60.21.20.50.2-0.1-0.10.1-0.70.9-0.5
Glucose0.40.61.91.4-1.40.30.70.5-1.20.20.50.70.7-0.7-0.3-0.9-0.4
Heart weight2.94.26.6-0.61.2-2.5-1.3-2.40.9-2.6-2.4-2.3-2.32.32.51.52.2
Delay discount hyperbolic model param1.61.75.7-2.42.30.7-1.10.22.20.80.1-0.5-0.50.5-1.01.8-1.0
Intermittent access intake day 1-15 change0.90.93.3-1.81.80.0-0.7-0.31.60.0-0.4-0.7-0.70.7-0.01.10.2
Intermittent access intake escalation1.01.02.8-1.61.7-0.4-0.7-0.71.4-0.5-0.8-1.0-1.01.00.51.10.7
Intermittent access intake escalation 21.11.11.7-0.91.2-0.7-1.1-1.11.3-0.7-1.1-1.3-1.31.30.51.20.6
Intermitt. access day 1 inactive lever presses0.70.82.8-1.71.7-0.0-0.8-0.11.50.1-0.2-0.6-0.60.6-0.11.20.1
Intermitt. access day 15 inactive lever presses2.72.95.7-0.2-0.42.30.72.1-0.32.42.11.81.8-1.8-2.3-0.6-2.3
Intermitt. access escalation Index1.11.01.80.20.3-1.3-0.9-1.30.4-1.4-1.3-1.1-1.11.11.00.41.1
Intermittent access day 1 total infusions0.70.81.81.0-0.6-1.4-0.3-1.1-0.4-1.3-1.1-0.8-0.80.80.9-0.11.0
Intermittent access day 15 total infusions1.21.31.9-0.71.0-1.3-0.9-1.31.0-1.2-1.3-1.4-1.41.40.91.01.1
Intermittent access terminal intake (last 3 days)0.70.71.3-0.10.4-0.9-0.8-1.10.6-0.8-1.1-1.1-1.11.10.40.80.6
Intermittent access total infusions0.30.40.70.8-0.5-0.9-0.2-0.7-0.4-0.8-0.7-0.5-0.50.50.5-0.20.7
Intermittent access day 1 locomotion0.80.82.61.6-1.2-1.1-0.1-0.9-0.9-1.1-0.8-0.5-0.50.50.8-0.40.9
Intermittent access day 15 total locomotion1.21.32.40.20.1-1.4-0.3-1.40.1-1.6-1.4-1.2-1.21.21.50.21.5
Intermittent access total locomotion1.11.32.41.4-0.9-1.5-0.2-1.4-0.8-1.5-1.3-1.0-1.01.01.3-0.31.4
Intermittent access standard deviation1.21.22.6-1.30.91.4-0.21.30.91.51.20.70.7-0.7-1.60.3-1.5
Left kidney weight1.13.210.9-3.32.02.03.01.90.31.31.71.71.7-1.70.1-0.3-0.6
Right kidney weight1.13.18.1-2.71.52.32.81.90.01.61.81.81.8-1.8-0.5-0.8-1.0
Cocaine induced anxiety0.20.30.70.8-0.6-0.7-0.1-0.6-0.5-0.7-0.6-0.4-0.40.40.6-0.20.4
Post-drug Anxiety1.21.37.02.6-2.3-0.60.4-0.4-1.9-0.6-0.30.20.2-0.20.3-1.30.0
Baseline Anxiety1.81.95.82.4-2.40.60.70.8-1.90.70.91.21.2-1.2-0.9-1.6-0.8
Tail length0.61.911.1-1.50.41.53.31.1-1.00.61.01.31.3-1.30.6-1.50.4
Length with tail2.38.529.9-3.21.23.85.53.2-0.92.63.03.13.1-3.1-0.7-2.2-0.9
Length without tail3.57.716.7-1.80.23.64.13.4-1.02.93.33.33.3-3.3-1.8-2.0-1.9
Times rat made contact with spout0.00.00.3-0.20.1-0.00.6-0.1-0.1-0.3-0.1-0.0-0.00.00.1-0.20.1
Lifetime Intake0.10.20.80.9-0.8-0.20.1-0.1-0.6-0.1-0.10.00.0-0.0-0.2-0.5-0.0
Liver weight, left1.11.76.0-2.42.11.2-0.41.21.91.41.10.50.5-0.5-0.91.4-1.1
Liver weight, right0.60.94.0-2.01.41.01.01.00.70.80.90.60.6-0.6-0.40.3-0.7
Locomotor activity1.82.97.9-0.81.0-1.90.2-1.90.1-2.2-2.0-1.7-1.71.72.80.92.4
Locomotor testing distance0.71.22.4-1.41.5-0.8-0.6-0.91.0-0.9-1.0-1.1-1.11.11.21.21.0
Locomotor testing rearing0.40.61.5-1.01.2-0.4-1.2-0.31.1-0.3-0.3-0.6-0.60.60.11.00.3
Locomotion in novel chamber0.20.30.7-0.80.8-0.5-0.2-0.40.7-0.5-0.4-0.5-0.50.50.60.50.3
Locomotion in novel chamber post-restriction1.41.73.6-1.11.2-1.20.0-1.30.7-1.4-1.3-1.4-1.41.41.91.01.8
Fecal boli incidents, locomotor time 10.40.41.1-0.60.6-0.60.1-0.70.2-0.8-0.7-0.6-0.60.61.10.60.7
Change in fecal boli incidents, locomotor task0.80.71.50.3-0.41.10.21.0-0.31.21.00.90.9-0.9-1.2-0.7-0.6
Time >=10cm from walls, locomotor time 11.21.24.32.1-2.00.20.70.4-1.40.20.50.80.8-0.8-0.6-1.5-1.1
Bouts of movement, locomotor time 10.20.30.9-0.90.8-0.20.3-0.40.3-0.3-0.5-0.5-0.50.50.70.50.3
Total resting periods, locomotor time 10.30.30.6-0.80.6-0.30.4-0.50.1-0.4-0.6-0.5-0.50.50.80.50.5
Rest time, locomotor task time 10.10.10.5-0.30.00.50.7-0.0-0.20.4-0.1-0.1-0.10.1-0.4-0.0-0.7
Distance moved, locomotor task time 10.40.41.20.5-0.3-1.1-0.5-0.4-0.1-1.1-0.3-0.2-0.20.21.10.01.0
Vertical activity count, locomotor time 11.41.53.4-0.20.5-1.6-0.8-1.30.5-1.6-1.3-1.2-1.21.21.81.01.5
Time >=10cm from walls, locomotor time 22.62.84.81.3-1.71.52.21.4-1.81.31.51.81.8-1.8-1.1-2.2-1.5
Bouts of movement, locomotor time 20.30.31.0-1.00.8-0.10.4-0.30.5-0.2-0.3-0.4-0.40.40.70.50.8
Total resting periods, locomotor time 20.20.21.1-1.10.80.20.40.00.50.1-0.0-0.1-0.10.10.40.40.5
Rest time, locomotor task time 20.00.10.10.3-0.3-0.0-0.1-0.3-0.10.0-0.3-0.3-0.30.3-0.1-0.0-0.2
Distance moved, locomotor task time 20.10.10.3-0.50.6-0.2-0.30.30.5-0.20.40.30.3-0.30.20.30.2
Vertical activity count, locomotor time 20.80.92.6-1.61.5-0.4-0.2-0.61.1-0.5-0.7-0.8-0.80.80.81.20.7
Light reinforcement 10.61.23.31.8-1.4-1.30.1-1.0-1.2-1.4-0.9-0.5-0.50.51.2-0.71.2
Light reinforcement 20.10.10.3-0.20.3-0.2-0.5-0.10.5-0.1-0.1-0.2-0.20.2-0.00.30.3
Bone: marrow area0.51.04.8-2.22.00.3-0.50.01.70.3-0.0-0.4-0.40.4-0.31.2-0.0
Bone: maximum diameter0.40.71.3-0.90.41.11.11.10.00.91.00.90.9-0.9-0.6-0.4-0.6
Bone: maximum force0.20.31.2-1.10.70.61.10.60.10.30.50.50.5-0.50.0-0.2-0.3
Bone: maximum moment0.20.31.3-1.10.80.70.90.60.30.40.50.40.4-0.4-0.2-0.1-0.5
Mean time between licks in bursts0.40.51.80.30.1-0.8-1.3-0.80.5-0.6-0.8-0.9-0.90.90.40.70.5
Mean num. licks in bursts0.20.20.60.8-0.8-0.10.50.1-0.7-0.20.10.20.2-0.20.0-0.6-0.0
Cd content in liver4.04.47.7-0.51.4-2.3-2.8-2.41.9-2.0-2.4-2.6-2.62.61.22.01.4
Co content in liver1.01.23.8-1.91.9-0.0-1.2-0.21.90.1-0.3-0.8-0.80.8-0.51.3-0.2
Cu content in liver0.50.61.7-0.81.0-0.5-1.1-0.51.3-0.4-0.5-0.8-0.80.80.20.9-0.0
Fe content in liver0.30.41.4-0.60.6-0.70.3-0.60.3-0.9-0.7-0.6-0.60.61.20.30.5
K content in liver0.10.10.10.1-0.20.30.40.3-0.10.20.30.30.3-0.30.3-0.10.2
Mg content in liver0.10.10.3-0.20.00.50.50.50.00.30.50.40.4-0.40.1-0.3-0.0
Mn content in liver0.10.10.3-0.00.10.3-0.50.30.40.50.30.10.1-0.1-0.30.4-0.5
Na content in liver0.30.40.80.6-0.70.30.90.4-0.90.10.40.70.7-0.70.3-0.8-0.2
Rb content in liver0.20.20.90.8-0.4-0.6-0.9-0.30.1-0.4-0.3-0.3-0.30.30.20.00.3
Se content in liver1.31.63.91.5-1.80.71.90.7-1.90.30.81.21.2-1.2-0.1-2.0-0.1
Sr content in liver0.90.82.6-1.61.40.9-0.60.71.31.00.70.20.2-0.2-0.80.8-0.5
Zn content in liver1.21.34.9-2.21.71.40.31.21.31.31.10.70.7-0.7-0.90.6-0.8
Bone: minimum diameter0.00.00.1-0.30.3-0.1-0.2-0.00.3-0.1-0.1-0.2-0.20.20.10.4-0.1
Time in familiar zone, hab. session 11.11.02.0-0.60.41.2-0.31.30.61.41.20.90.9-0.9-1.40.1-1.4
Time in novel zone, hab. session 10.20.20.50.3-0.4-0.30.7-0.4-0.7-0.4-0.4-0.2-0.20.20.6-0.30.4
Total zone transitions, hab. session 11.72.43.91.4-0.8-2.0-0.9-2.0-0.5-1.9-1.9-1.6-1.61.61.70.32.0
Total locomotion distance, hab. session 10.50.71.81.2-1.0-0.8-0.0-0.8-0.9-0.8-0.8-0.5-0.50.51.0-0.21.3
Locomotion velocity, hab. session 10.91.33.31.6-1.1-1.4-0.4-1.2-0.9-1.3-1.1-0.8-0.80.81.3-0.21.8
Time in familiar zone, hab. session 21.41.42.20.4-0.71.40.81.4-0.51.31.51.41.4-1.4-1.4-1.2-1.1
Time in novel zone, hab. session 21.51.52.60.20.2-1.5-0.8-1.60.1-1.4-1.6-1.5-1.51.51.50.91.2
Total zone transitions, hab. session 20.30.31.00.10.0-0.7-0.1-0.7-0.1-0.8-0.7-0.6-0.60.61.00.30.6
Total locomotion distance, hab. session 20.50.61.50.3-0.1-1.0-0.4-0.9-0.1-0.9-0.9-0.8-0.80.81.20.51.2
Locomotion velocity, hab. session 20.50.71.50.3-0.0-1.0-0.5-1.0-0.0-1.0-0.9-0.8-0.80.81.20.61.2
Novel to familiar place preference ratio0.30.30.60.10.0-0.6-0.1-0.6-0.1-0.6-0.7-0.6-0.60.60.80.50.4
Novelty place preference0.40.40.70.2-0.0-0.8-0.3-0.8-0.1-0.7-0.8-0.7-0.70.70.90.50.4
Time in novel zone, NPP test0.20.30.60.1-0.0-0.6-0.2-0.6-0.1-0.6-0.7-0.6-0.60.60.80.40.4
Total zone transitions, NPP test0.30.51.10.5-0.3-0.8-0.0-0.9-0.4-0.9-0.8-0.6-0.60.61.0-0.11.0
Total locomotion distance, NPP test0.60.92.11.2-1.0-1.00.4-0.9-1.1-1.1-0.8-0.5-0.50.51.3-0.51.4
Locomotion velocity, NPP test1.11.53.70.9-0.6-1.50.0-1.5-0.8-1.6-1.4-1.1-1.11.11.8-0.01.9
Intraocular pressure0.30.41.9-1.41.2-0.10.2-0.10.6-0.2-0.2-0.3-0.30.30.80.80.3
Delta distance traveled before/after self-admin0.91.01.7-1.11.3-0.7-1.0-0.91.3-0.6-0.9-1.1-1.11.10.61.21.0
Delta ambulatory time before/after self-admin0.60.71.2-0.60.9-0.7-1.1-0.71.0-0.5-0.7-0.9-0.90.90.41.00.8
Parametrial fat weight0.51.02.5-0.50.11.50.61.30.11.61.31.11.1-1.1-1.0-0.0-1.1
Pavlov. Cond. lever latency0.60.82.5-1.61.11.20.81.00.61.00.90.80.8-0.8-0.5-0.1-0.1
Pavlov. Cond. magazine entry latency0.10.10.30.4-0.4-0.30.4-0.4-0.5-0.5-0.4-0.3-0.30.30.6-0.2-0.1
Pavlov. Cond. change in total contacts0.91.03.41.8-1.80.01.00.2-1.7-0.10.20.60.6-0.6-0.2-1.3-0.4
Pavlov. Cond. index score0.20.31.01.0-0.9-0.40.3-0.4-0.8-0.5-0.3-0.1-0.10.10.3-0.4-0.3
Pavlov. Cond. latency score0.30.41.81.3-1.2-0.60.2-0.5-1.0-0.6-0.5-0.2-0.20.20.5-0.5-0.1
Pavlov. Cond. lever contacts0.40.52.21.5-1.1-0.8-0.4-0.7-0.8-0.6-0.6-0.4-0.40.40.2-0.2-0.1
Pavlov. Cond. magazine entry number0.30.30.9-0.30.20.7-0.30.80.40.90.80.60.6-0.6-0.9-0.0-0.1
Pavlov. Cond. intertrial magazine entries0.50.61.7-0.10.4-0.8-1.3-0.70.7-0.6-0.7-0.8-0.80.80.10.51.1
Pavlov. Cond. lever-magazine prob. diff.0.20.20.80.9-0.9-0.10.4-0.1-0.8-0.2-0.10.10.1-0.10.0-0.4-0.6
Pavlov. Cond. response bias0.20.20.40.6-0.5-0.50.3-0.5-0.6-0.6-0.5-0.3-0.30.30.5-0.1-0.2
Pavlov. Cond. lever latency1.11.42.7-1.51.11.5-0.31.41.11.61.30.90.9-0.9-1.70.4-1.1
Pavlov. Cond. magazine entry latency1.21.45.42.3-2.1-0.90.6-0.7-1.9-1.0-0.7-0.2-0.20.21.3-0.80.8
Pavlov. Cond. change in total contacts1.21.63.90.9-0.5-1.7-0.3-1.6-0.5-1.8-1.6-1.3-1.31.32.00.21.3
Pavlov. Cond. index score1.62.04.11.7-1.3-1.8-0.0-1.7-1.2-1.9-1.6-1.1-1.11.12.0-0.21.5
Pavlov. Cond. latency score1.21.53.11.8-1.4-1.50.1-1.3-1.3-1.6-1.3-0.8-0.80.81.7-0.31.3
Pavlov. Cond. lever contacts0.81.12.21.5-1.2-1.20.3-1.1-1.2-1.3-1.0-0.6-0.60.61.4-0.51.0
Pavlov. Cond. magazine entry number1.31.63.3-1.81.41.60.11.41.11.61.30.90.9-0.9-1.80.1-1.2
Pavlov. Cond. intertrial magazine entries0.20.30.8-0.90.9-0.2-0.3-0.40.7-0.3-0.4-0.5-0.50.50.30.40.7
Pavlov. Cond. lever-magazine prob. diff.1.72.24.61.8-1.3-1.9-0.1-1.7-1.2-2.0-1.7-1.2-1.21.22.1-0.11.6
Pavlov. Cond. response bias1.72.34.51.9-1.5-1.90.1-1.7-1.3-2.0-1.7-1.1-1.11.12.1-0.31.7
Time in closed arm before self-admin0.91.04.1-2.01.9-0.2-0.4-0.31.5-0.2-0.4-0.6-0.60.60.51.30.5
Time in closed arm after self-admin2.12.23.0-1.31.5-1.3-0.6-1.61.1-1.4-1.7-1.7-1.71.71.61.41.6
Time in open arm before self-admin0.20.20.90.6-0.6-0.10.60.3-0.6-0.30.30.50.5-0.50.1-0.9-0.1
Time in open arm after self-admin0.40.40.60.5-0.60.50.10.7-0.30.50.80.80.8-0.8-0.7-0.6-0.6
Bone: periosteal estimation0.20.31.3-1.20.80.70.90.50.30.40.50.40.4-0.4-0.1-0.1-0.1
Bone: periosteal perimeter0.20.31.00.0-0.0-0.50.7-0.4-0.4-0.7-0.4-0.3-0.30.31.0-0.20.8
Bone: post-yield work0.10.10.4-0.60.60.1-0.00.00.40.00.0-0.1-0.10.1-0.40.3-0.4
Progressive ratio test 1 active lever presses0.00.00.3-0.50.4-0.00.30.10.1-0.10.00.00.0-0.00.10.1-0.0
Progressive ratio test 1 breakpoint0.00.00.2-0.40.3-0.00.40.10.0-0.10.10.10.1-0.10.2-0.0-0.1
Progressive ratio test 1 inactive lever presses1.11.22.6-1.51.6-0.8-0.6-0.81.3-0.8-0.9-1.0-1.01.01.01.21.3
Progressive ratio test 2 active lever presses1.11.22.1-0.60.8-1.3-0.1-1.20.5-1.5-1.3-1.2-1.21.21.40.61.3
Progressive ratio test 2 breakpoint1.41.53.0-0.30.6-1.6-0.3-1.50.3-1.7-1.5-1.4-1.41.41.60.51.4
Progressive ratio test 2 inactive lever presses2.32.67.0-2.52.7-0.9-1.0-1.12.2-0.9-1.2-1.5-1.51.51.01.81.2
Incentive Sensitization - Responses1.81.93.1-0.10.6-1.8-0.9-1.70.6-1.8-1.7-1.6-1.61.61.50.81.3
Incentive Sensitization - Breakpoint2.12.23.6-0.10.7-1.9-1.0-1.80.7-1.9-1.8-1.7-1.71.71.60.91.5
Sum of active levers in priming session hrs 5-61.21.12.81.4-1.71.01.00.6-1.51.00.60.80.8-0.8-0.8-0.9-1.2
Progressive ratio0.40.50.90.3-0.30.7-0.10.90.00.80.90.90.9-0.9-0.9-0.6-0.3
Food seeking constrained by brief footshock0.91.13.3-1.11.40.2-1.80.11.80.60.1-0.4-0.40.4-1.31.3-1.1
Seeking ratio, punishment vs. effort0.40.51.2-1.11.1-0.1-0.5-0.40.9-0.1-0.5-0.7-0.70.7-0.11.1-0.6
Retroperitoneal fat weight1.85.811.43.0-3.41.72.12.0-3.01.72.12.52.5-2.5-1.5-2.6-2.0
Reaction time number correct1.42.14.2-1.82.0-0.9-1.4-1.11.8-0.8-1.2-1.5-1.51.50.92.00.9
Reaction time mean minus median2.02.76.12.3-2.1-1.41.4-1.3-2.5-1.8-1.3-0.5-0.50.52.2-1.31.8
Reaction time mean minus median AUC2.02.75.11.4-0.9-2.1-0.2-2.0-1.0-2.3-1.9-1.5-1.51.52.30.12.0
Reaction time num false alarms1.52.14.11.3-0.8-1.9-0.2-1.7-1.0-2.0-1.6-1.2-1.21.22.0-0.11.9
Reaction time num false alarms AUC1.11.53.11.0-0.7-1.6-0.1-1.4-0.8-1.7-1.4-1.1-1.11.11.8-0.11.6
Reaction time trials correct on left1.42.14.2-1.82.0-0.9-1.4-1.11.8-0.8-1.2-1.5-1.51.50.92.00.9
Reaction time trials on left1.42.03.9-1.72.0-0.9-1.3-1.11.7-0.8-1.2-1.5-1.51.50.91.90.9
Reaction time mean1.31.88.22.9-2.5-0.90.7-0.5-2.3-0.9-0.30.20.2-0.20.6-1.70.6
Reaction time mean AUC1.31.77.62.8-2.4-1.10.4-0.7-2.0-1.1-0.6-0.1-0.10.10.8-1.40.8
Median of all reaction times1.11.57.62.8-2.4-0.50.3-0.1-2.0-0.50.10.50.5-0.5-0.0-1.60.1
Reaction time omissions0.60.83.11.8-1.5-0.80.5-0.6-1.3-0.9-0.6-0.2-0.20.20.6-0.90.3
Reaction time false alarm rate0.81.13.11.8-1.6-1.00.6-0.8-1.6-1.2-0.7-0.3-0.30.31.2-1.01.1
Reaction time premature initiation rate0.30.41.00.9-0.9-0.50.7-0.4-0.9-0.7-0.4-0.1-0.10.11.0-0.60.8
Reaction time premature initiations0.40.61.70.10.1-0.90.0-0.9-0.1-1.0-0.9-0.7-0.70.71.30.31.1
Std. dev. reaction times1.31.85.62.4-2.2-1.11.1-0.9-2.2-1.3-0.8-0.2-0.20.21.4-1.31.1
Reaction time trials completed1.42.03.9-1.72.0-0.9-1.3-1.11.7-0.8-1.2-1.5-1.51.50.91.90.9
Reaction time trials AUC1.62.34.0-1.61.9-1.1-1.5-1.31.7-1.0-1.4-1.7-1.71.71.02.01.0
Run reversals in cocaine runway, females0.10.10.30.00.1-0.2-0.5-0.30.20.0-0.3-0.3-0.30.3-0.10.5-0.1
Run reversals in cocaine runway, males2.82.73.6-1.11.5-1.5-1.7-1.71.6-1.4-1.7-1.9-1.91.91.31.81.6
Latency to leave start box in cocaine runway0.30.31.00.9-1.00.30.60.2-1.00.20.20.40.4-0.4-0.2-0.8-0.5
Latency to leave start box in cocaine runway, F1.11.22.00.1-0.51.41.01.2-0.71.41.21.21.2-1.2-1.2-0.7-1.4
Latency to leave start box in cocaine runway, M2.72.64.60.8-0.2-2.1-1.1-2.1-0.0-2.1-2.1-1.9-1.91.91.80.71.4
Std. dev. time between licks in bursts0.81.02.0-0.30.5-1.2-0.4-1.20.3-1.2-1.2-1.2-1.21.21.40.81.0
Total sessions with >9 infusions0.10.10.20.4-0.4-0.00.40.2-0.5-0.10.20.20.2-0.2-0.1-0.5-0.4
Short access day 1 total inactive lever presses0.10.10.4-0.70.50.4-0.10.30.40.50.30.10.1-0.1-0.30.4-0.2
Short access day 10 total inactive lever presses1.31.44.0-2.01.41.60.31.31.11.61.20.90.9-0.9-1.10.3-0.8
Short access day 1 total infusions1.21.34.60.4-0.51.1-0.21.2-0.11.41.21.01.0-1.0-1.9-0.3-2.1
Short access day 10 total infusions0.20.20.50.4-0.2-0.6-0.7-0.60.1-0.4-0.6-0.6-0.60.6-0.00.30.4
Short access total infusions1.21.42.41.0-1.31.10.71.2-1.11.21.21.21.2-1.2-1.5-1.0-1.4
Short access day 1 locomotion0.70.83.41.9-1.7-0.50.5-0.2-1.5-0.6-0.10.10.1-0.10.2-1.0-0.5
Short access day 10 total locomotion0.10.10.20.1-0.10.3-0.30.20.10.50.20.10.1-0.1-0.50.1-0.4
Short access total locomotion0.60.72.31.5-1.50.30.60.4-1.30.40.40.60.6-0.6-0.5-0.9-0.7
One hour access (0.3 mA shock)3.94.56.2-1.42.1-2.3-2.0-2.32.1-2.1-2.3-2.5-2.52.51.62.01.7
Compulsive drug intake0.60.72.60.50.1-1.1-1.6-0.80.6-0.7-0.8-0.9-0.90.90.20.80.3
One hour access (shock baseline)1.51.82.8-0.91.2-1.4-0.3-1.60.8-1.6-1.6-1.5-1.51.51.60.81.7
Social response proportion0.80.95.60.3-0.70.22.40.2-1.4-0.40.10.60.6-0.61.2-1.10.7
Social responses0.81.02.8-0.80.8-1.00.3-1.10.3-1.3-1.2-1.0-1.01.01.70.61.0
Social time1.62.24.11.6-1.0-2.0-0.9-1.9-0.6-1.9-1.8-1.5-1.51.51.60.31.4
Soleus weight0.10.42.6-1.61.30.40.50.10.80.20.0-0.1-0.10.1-0.20.4-0.0
Bone: stiffness0.30.51.50.00.0-0.80.5-0.8-0.3-1.0-0.8-0.6-0.60.61.2-0.11.1
Tibialis anterior weight0.93.114.1-1.40.12.03.81.7-1.21.21.71.91.9-1.9-0.3-1.9-0.1
Time to tail flick, vehicle, before self-admin1.11.14.42.1-2.1-0.11.1-0.5-2.0-0.2-0.5-0.0-0.00.00.5-0.90.2
Time to tail flick, vehicle, after self-admin0.80.81.80.8-0.5-1.1-0.2-1.3-0.5-1.2-1.3-1.1-1.11.10.90.30.3
Time to tail flick, test, before self-admin0.20.20.5-0.60.40.50.40.70.20.40.70.60.6-0.6-0.1-0.3-0.1
Time to tail flick, test, after self-admin1.51.52.00.8-1.31.31.41.1-1.41.21.21.31.3-1.3-1.0-1.2-1.4
Delta time to tail flick, vehicle, before/after SA0.70.71.8-0.61.0-1.0-1.3-0.71.1-0.9-0.7-0.9-0.90.90.30.80.1
Delta time to tail flick, test, before/after SA0.40.41.10.5-0.70.70.30.4-0.60.70.40.40.4-0.4-0.9-0.3-1.1
Tibia length2.16.010.7-1.40.13.33.13.0-0.82.82.92.82.8-2.8-2.1-1.8-2.1
Ambulatory time before self-admin1.11.12.21.2-1.0-1.20.4-1.1-1.1-1.3-1.1-0.7-0.70.71.5-0.41.5
Ambulatory time after self-admin0.40.52.10.5-0.1-1.1-0.3-0.5-0.1-1.1-0.4-0.2-0.20.21.1-0.41.4
Bone: tissue strength0.90.91.9-1.41.20.7-0.80.81.41.00.80.30.3-0.3-1.21.0-1.3
Total heroin consumption1.72.05.02.2-1.4-2.0-0.9-1.6-0.9-1.9-1.4-1.1-1.11.11.3-0.41.1
Bone: trabecular number1.11.74.0-2.01.31.81.21.50.71.51.41.11.1-1.1-1.2-0.2-1.1
Bone: trabecular spacing0.40.51.41.2-0.7-0.9-1.2-0.7-0.2-0.6-0.6-0.6-0.60.60.40.40.2
Bone: trabecular thickness0.91.12.4-1.60.91.41.31.30.31.11.21.01.0-1.0-0.8-0.4-0.8
Bone: trabecular tissue density1.82.67.82.6-2.5-1.01.9-0.8-2.8-1.3-0.70.10.1-0.12.0-1.61.1
Water consumed over 24 hours0.50.63.7-1.91.70.40.10.21.20.30.1-0.1-0.10.1-0.10.9-0.1
Number of responses in last shaping day0.10.10.3-0.60.6-0.0-0.2-0.00.50.0-0.1-0.3-0.30.3-0.20.4-0.4