Pdlim1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Pdlim1 0.04 0.03 1.2e-04 0.01 0.02 0.02 0.02 1.0e-02 1.3e-03 4.3e-03 5.2e-03
2 OFC gene expression Pdlim1 0.3 0.18 2.1e-05 0.1 0.18 0.16 0.14 2.1e-03 3.6e-05 1.1e-04 2.9e-04
3 Eye gene expression Pdlim1 0.73 0.19 5.2e-06 0.22 0.23 0.22 0.21 3.1e-04 2.2e-04 2.9e-04 3.4e-04
4 PL gene expression Pdlim1 0.15 0.09 0.0e+00 0.16 0.18 0.17 0.18 1.3e-17 1.6e-19 4.5e-18 9.2e-20
5 Adipose mRNA stability Pdlim1 0.02 0.02 8.0e-03 0.01 0.01 0.01 0.01 5.3e-02 1.6e-02 3.4e-02 5.3e-02
6 pVTA gene expression Pdlim1 0.11 0.08 3.5e-04 0.05 0.1 0.1 0.08 2.5e-03 5.8e-05 5.2e-05 2.4e-04
7 Brain gene expression Pdlim1 0.14 0.1 1.4e-12 0.13 0.12 0.13 0.13 3.7e-12 1.4e-11 3.8e-12 3.7e-12
8 Adipose gene expression Pdlim1 0.12 0.08 1.2e-06 0.02 0.04 0.04 0.04 1.8e-03 2.3e-05 1.1e-05 1.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.61.01.71.3-1.31.2-1.0-0.90.81.0-0.2
Area under the delay curve1.51.62.8-1.01.0-1.21.31.4-1.5-0.9-1.7
BMI with tail0.92.84.12.0-2.01.9-1.9-1.41.31.80.1
BMI without tail1.43.04.22.0-2.01.9-1.8-1.61.61.70.6
Body weight0.62.42.91.5-1.51.6-1.7-1.61.61.51.1
Weight adjusted by age0.40.51.01.0-1.00.9-0.6-0.50.40.5-0.2
Bone surface1.52.63.51.9-1.91.8-1.6-1.51.51.70.5
Bone volume1.62.83.51.9-1.91.8-1.7-1.61.71.80.7
Breakpoint value in progressive ratio session0.80.91.3-1.21.1-1.10.91.0-1.2-0.3-0.4
Number of licking bursts2.73.24.9-1.41.4-1.61.81.9-2.0-1.8-2.2
Context. condit. distance diff. score0.20.30.60.5-0.50.5-0.6-0.50.40.80.5
Locomotion velocity, session 16.06.57.7-2.32.3-2.52.72.7-2.8-2.4-2.6
Locomotion distance, session 11.72.12.6-1.51.5-1.51.61.5-1.5-1.3-1.3
Locomotion velocity, session 21.01.11.5-0.90.9-1.01.11.2-1.2-1.0-1.2
Locomotion distance, session 20.81.11.3-0.80.9-0.91.11.1-1.0-1.1-1.2
Locomotion velocity, session 30.10.20.8-0.40.4-0.30.1-0.00.1-0.10.9
Locomotion distance, session 30.70.84.5-0.20.20.0-0.4-0.70.80.42.1
Stereotopy head waving bouts, day 30.30.30.4-0.50.5-0.50.60.6-0.6-0.5-0.5
Stereotopy head waving duration, day 30.50.61.2-0.50.5-0.60.80.8-0.9-0.6-1.1
Locomotion velocity, session 70.80.81.40.7-0.70.8-0.9-0.91.00.91.2
Locomotion distance, session 70.91.11.41.0-1.01.0-1.0-1.11.21.01.0
Stereotopy head waving bouts, day 72.83.14.1-1.91.9-1.91.81.9-2.0-1.4-1.2
Stereotopy head waving duration, day 70.70.81.2-1.01.0-1.00.91.0-1.1-0.7-0.5
Locomotion velocity, session 80.00.00.1-0.20.2-0.20.30.2-0.20.10.0
Locomotion distance, session 80.10.10.3-0.10.1-0.20.30.4-0.5-0.0-0.5
Degree of sensitization distance0.50.52.70.2-0.2-0.00.40.5-0.6-0.4-1.6
Degree of sensitization stereotypy2.12.33.0-1.71.7-1.61.51.6-1.7-1.2-0.9
Conditioned locomotion1.71.92.31.5-1.51.5-1.5-1.41.31.50.6
Cocaine response after cond. corrected0.10.20.5-0.20.2-0.30.40.5-0.4-0.1-0.7
Cocaine response after cond. not corrected0.30.30.5-0.70.7-0.70.60.6-0.5-0.5-0.2
Cocaine response before conditioning0.91.11.7-1.31.3-1.21.00.8-0.7-1.30.5
Saline control response1.92.53.6-1.91.9-1.81.51.6-1.5-1.5-0.6
Bone: connectivity density1.82.94.62.2-2.12.0-1.7-1.51.41.7-0.1
Bone: cortical apparent density2.33.03.6-1.51.5-1.71.81.9-1.8-1.7-1.9
Bone: cortical area1.62.45.90.9-1.01.2-1.5-1.61.71.62.4
Bone: cortical porosity0.60.72.5-0.20.2-0.40.60.9-1.0-0.7-1.6
Bone: cortical porosity0.20.20.70.0-0.0-0.10.20.4-0.6-0.4-0.9
Bone: cortical thickness0.61.01.9-1.41.4-1.20.70.6-0.6-0.60.9
Bone: cortical thickness2.52.93.9-2.01.9-1.91.71.7-1.9-1.5-0.5
Bone: cortical tissue density2.33.04.3-1.41.5-1.61.81.9-1.8-1.7-2.1
Condit. Reinf. active minus inactive responses0.40.40.8-0.90.9-0.80.70.6-0.5-0.60.0
Condit. Reinf. active-inactive response ratio0.10.10.2-0.50.5-0.40.30.2-0.1-0.10.4
Condit. Reinf. active responses0.20.30.5-0.70.7-0.70.60.5-0.3-0.60.0
Condit. Reinf. inactive responses0.30.40.7-0.50.5-0.60.70.6-0.5-0.9-0.8
Incentive salience index mean0.40.51.0-1.01.0-0.90.60.5-0.4-0.50.5
Condit. Reinf. lever presses0.40.50.9-0.90.9-0.80.60.5-0.6-0.50.3
Condit. Reinf. active minus inactive responses2.22.83.31.8-1.81.8-1.8-1.71.61.70.8
Condit. Reinf. active-inactive response ratio1.21.21.81.3-1.31.2-1.1-1.01.01.10.2
Condit. Reinf. active responses1.72.42.81.3-1.31.4-1.7-1.71.71.61.7
Condit. Reinf. inactive responses0.50.63.2-0.30.20.0-0.5-0.60.60.51.8
Condit. Reinf. lever presses0.10.20.5-0.60.6-0.50.30.1-0.1-0.30.7
Condit. Reinf. lever reinforcers received0.91.21.70.9-0.91.0-1.2-1.21.21.21.3
Conditioned reinforcement - actives0.30.30.5-0.60.6-0.60.60.4-0.2-0.70.2
Conditioned reinforcement - inactives0.30.40.9-0.70.7-0.70.50.7-0.9-0.2-0.0
Conditioned locomotion0.81.01.4-1.21.2-1.11.10.9-0.6-1.1-0.2
Patch foraging indifference point 0 sec0.10.20.5-0.70.7-0.60.40.3-0.0-0.20.3
Patch foraging indifference point AUC4.55.16.5-2.52.5-2.52.42.3-2.4-1.9-1.2
Delay disc. indifference point, 0s delay0.60.71.11.1-1.10.9-0.8-0.50.40.8-0.7
Delay disc. indifference point, 16s delay1.21.21.7-1.01.0-1.11.11.2-1.3-0.9-1.3
Delay disc. indifference point, 2s delay0.30.42.30.2-0.2-0.00.30.4-0.5-0.1-1.5
Delay disc. indifference point, 24s delay4.34.14.9-2.12.2-2.22.22.1-2.0-1.9-1.5
Delay disc. indifference point, 4s delay0.91.01.8-0.80.8-0.91.01.1-1.1-0.6-1.3
Delay disc. indifference point, 8s delay3.94.15.1-1.91.9-2.02.12.2-2.2-1.7-2.0
Indifference point function ln k3.75.16.52.6-2.52.5-2.4-2.32.32.11.0
Indifference point function log k3.75.16.52.6-2.52.5-2.4-2.32.32.11.0
Patch foraging total patch changes 0 sec0.10.20.4-0.60.5-0.40.20.10.2-0.10.7
Patch foraging total patch changes 12 sec3.34.25.4-2.32.3-2.32.22.1-2.1-1.8-1.1
Patch foraging total patch changes 18 sec1.11.41.7-1.21.2-1.21.21.3-1.3-0.8-1.2
Patch foraging total patch changes 24 sec0.30.40.8-0.90.9-0.70.60.5-0.4-0.50.4
Patch foraging total patch changes 6 sec3.55.37.6-2.82.8-2.62.42.2-2.1-2.0-0.8
Patch foraging time to switch 0 sec0.71.11.7-0.80.8-0.91.01.2-1.3-1.0-1.3
Patch foraging water rate 0 sec0.91.52.81.0-1.01.2-1.3-1.31.21.71.1
Patch foraging water rate 12 sec0.30.51.10.5-0.50.6-0.7-0.80.90.71.0
Patch foraging water rate 18 sec0.20.30.50.4-0.40.4-0.4-0.60.60.60.7
Patch foraging water rate 24 sec0.40.61.30.7-0.70.7-0.6-0.80.71.10.5
Patch foraging water rate 6 sec0.10.20.30.4-0.40.4-0.5-0.40.20.60.5
Seeking ratio, delayed vs. immediate footshock0.10.10.5-0.30.3-0.20.0-0.20.3-0.30.7
Distance traveled before self-admin0.10.10.2-0.10.1-0.10.50.2-0.1-0.4-0.3
Distance traveled after self-admin0.40.40.90.9-0.90.8-0.5-0.60.70.30.1
Extensor digitorum longus weight0.10.40.60.8-0.70.7-0.7-0.70.80.40.3
Bone: elastic displacement0.40.51.70.9-0.90.7-0.4-0.10.00.4-1.3
Bone: elastic work0.30.40.70.9-0.80.8-0.6-0.30.10.7-0.6
Bone: endosteal estimation3.26.98.12.8-2.82.8-2.6-2.72.62.71.7
Bone: endosteal perimeter3.47.08.22.8-2.82.9-2.7-2.72.72.61.7
Epididymis fat weight1.84.25.12.3-2.32.3-2.1-2.12.01.91.2
Delta time in closed arm before/after self-admin0.20.20.9-0.30.3-0.20.1-0.20.20.11.0
Delta time in open arm before/after self-admin1.11.02.01.2-1.21.1-1.0-0.80.71.40.0
Diff in mean of infusions in LGA sessions0.70.71.90.9-0.90.9-0.8-0.80.71.40.1
Delay discount exponential model param1.61.72.71.1-1.11.2-1.3-1.51.51.01.6
Extinction: sum of active levers before priming0.40.41.20.5-0.50.5-0.6-0.60.31.10.4
Active lever presses in extinction session 60.50.51.60.7-0.70.6-0.40.0-0.30.8-1.3
Bone: final force0.10.21.0-0.10.10.1-0.2-0.30.30.31.0
Bone: final moment0.20.31.40.1-0.20.3-0.4-0.50.50.51.2
Food consumed during 24 hour testing period0.70.81.4-1.21.2-1.10.90.8-0.7-0.90.0
Glucose0.10.20.60.2-0.20.3-0.4-0.50.40.30.7
Heart weight0.20.21.4-0.20.2-0.0-0.3-0.3-0.00.41.2
Delay discount hyperbolic model param1.11.22.40.9-0.91.0-1.1-1.21.30.71.5
Intermittent access intake day 1-15 change1.91.92.31.5-1.51.5-1.5-1.41.41.30.8
Intermittent access intake escalation2.22.22.81.7-1.71.7-1.5-1.51.51.30.8
Intermittent access intake escalation 21.61.62.31.5-1.51.5-1.3-1.31.31.00.2
Intermitt. access day 1 inactive lever presses0.20.20.40.6-0.60.5-0.5-0.2-0.00.1-0.4
Intermitt. access day 15 inactive lever presses0.00.00.00.1-0.10.1-0.2-0.1-0.10.10.2
Intermitt. access escalation Index2.11.82.41.4-1.41.4-1.6-1.41.31.40.8
Intermittent access day 1 total infusions0.00.00.10.2-0.20.2-0.2-0.20.10.40.1
Intermittent access day 15 total infusions2.32.63.01.5-1.51.6-1.6-1.71.71.61.7
Intermittent access terminal intake (last 3 days)1.01.11.21.0-1.01.0-1.0-1.11.11.00.9
Intermittent access total infusions0.70.80.90.9-0.90.9-0.9-0.90.90.90.9
Intermittent access day 1 locomotion0.30.40.50.5-0.40.5-0.5-0.70.70.60.7
Intermittent access day 15 total locomotion0.80.81.2-1.01.0-1.01.10.9-0.8-1.1-0.1
Intermittent access total locomotion0.40.50.7-0.70.7-0.70.90.7-0.6-0.8-0.2
Intermittent access standard deviation1.41.41.71.1-1.11.2-1.2-1.21.31.21.3
Left kidney weight0.20.63.0-0.90.8-0.60.3-0.10.1-0.11.7
Right kidney weight0.41.23.5-1.51.4-1.20.70.3-0.4-0.21.9
Cocaine induced anxiety0.00.00.10.3-0.30.20.0-0.1-0.10.1-0.2
Post-drug Anxiety0.10.10.5-0.00.0-0.10.40.3-0.5-0.4-0.7
Baseline Anxiety0.00.00.1-0.10.1-0.20.10.2-0.1-0.2-0.2
Tail length0.20.73.50.0-0.10.3-0.4-0.91.00.41.9
Length with tail0.20.63.1-0.80.8-0.60.2-0.30.4-0.21.8
Length without tail0.30.61.2-1.11.1-0.90.50.2-0.2-0.51.1
Times rat made contact with spout0.30.30.6-0.40.4-0.50.50.6-0.5-0.8-0.7
Lifetime Intake0.20.20.30.4-0.40.4-0.4-0.40.30.60.4
Liver weight, left0.30.51.40.5-0.50.6-0.5-0.81.00.41.2
Liver weight, right0.91.52.70.9-0.91.0-1.2-1.31.41.31.6
Locomotor activity0.00.00.1-0.10.1-0.1-0.20.0-0.20.10.2
Locomotor testing distance0.00.00.1-0.10.1-0.0-0.2-0.0-0.10.30.3
Locomotor testing rearing0.20.40.50.7-0.70.7-0.6-0.50.50.7-0.1
Locomotion in novel chamber1.62.03.01.7-1.71.7-1.6-1.31.01.40.3
Locomotion in novel chamber post-restriction0.10.20.3-0.50.5-0.50.20.3-0.4-0.20.4
Fecal boli incidents, locomotor time 10.10.10.4-0.20.2-0.30.30.5-0.4-0.2-0.6
Change in fecal boli incidents, locomotor task0.10.10.4-0.20.2-0.10.1-0.10.1-0.60.4
Time >=10cm from walls, locomotor time 11.01.04.1-1.11.1-0.90.40.10.0-0.82.0
Bouts of movement, locomotor time 12.32.53.6-1.41.4-1.61.61.7-1.9-1.5-1.5
Total resting periods, locomotor time 13.74.15.5-2.02.0-2.12.02.1-2.4-1.9-1.6
Rest time, locomotor task time 11.71.84.3-0.90.9-1.11.21.5-1.8-0.8-2.1
Distance moved, locomotor task time 11.92.17.00.7-0.70.9-1.3-1.51.61.12.6
Vertical activity count, locomotor time 11.01.04.70.3-0.30.5-0.8-1.01.20.32.2
Time >=10cm from walls, locomotor time 20.40.40.7-0.80.8-0.70.60.3-0.1-0.70.8
Bouts of movement, locomotor time 24.54.86.1-1.92.0-2.12.22.3-2.5-2.3-2.2
Total resting periods, locomotor time 25.35.67.3-2.12.2-2.32.42.5-2.7-2.4-2.3
Rest time, locomotor task time 22.63.04.1-1.61.6-1.71.71.9-2.0-1.4-1.8
Distance moved, locomotor task time 21.61.94.30.9-0.91.1-1.2-1.51.61.42.1
Vertical activity count, locomotor time 20.30.31.20.3-0.20.4-0.4-0.60.60.61.1
Light reinforcement 10.10.10.4-0.20.2-0.20.50.4-0.2-0.4-0.6
Light reinforcement 22.43.24.1-1.41.4-1.62.01.9-1.9-1.8-2.0
Bone: marrow area3.27.08.22.9-2.92.9-2.6-2.72.62.71.6
Bone: maximum diameter4.27.78.42.8-2.82.9-2.9-2.92.82.92.1
Bone: maximum force0.10.20.50.4-0.40.4-0.4-0.50.40.60.7
Bone: maximum moment0.30.50.80.5-0.50.6-0.7-0.70.60.80.9
Mean time between licks in bursts0.20.30.80.3-0.30.4-0.4-0.60.60.30.9
Mean num. licks in bursts2.32.73.61.4-1.41.5-1.7-1.81.91.61.8
Cd content in liver0.40.40.6-0.80.8-0.70.70.6-0.5-0.80.1
Co content in liver0.30.41.10.3-0.40.5-0.6-0.70.70.61.1
Cu content in liver7.08.59.8-2.82.8-2.93.13.1-3.1-2.9-2.6
Fe content in liver1.31.51.8-1.11.1-1.21.31.4-1.4-1.3-1.3
K content in liver0.70.70.9-0.70.7-0.80.90.9-0.9-0.9-1.0
Mg content in liver1.21.21.6-0.90.9-1.01.21.2-1.2-1.1-1.3
Mn content in liver7.78.810.1-2.62.6-2.83.13.2-3.2-3.0-3.1
Na content in liver1.92.02.8-1.21.2-1.41.51.5-1.7-1.2-1.6
Rb content in liver0.20.30.4-0.50.5-0.50.60.6-0.6-0.5-0.4
Se content in liver19.423.728.3-4.84.9-5.05.15.1-5.0-5.3-3.6
Sr content in liver0.10.10.1-0.30.3-0.30.30.3-0.2-0.4-0.1
Zn content in liver0.91.01.1-1.01.0-1.01.01.0-1.0-1.0-0.9
Bone: minimum diameter8.014.916.83.7-3.73.9-3.9-4.14.04.13.4
Time in familiar zone, hab. session 10.20.20.30.5-0.50.5-0.3-0.20.20.5-0.4
Time in novel zone, hab. session 10.50.40.5-0.70.7-0.70.70.7-0.6-0.7-0.4
Total zone transitions, hab. session 10.30.40.6-0.50.5-0.50.60.7-0.7-0.4-0.8
Total locomotion distance, hab. session 12.12.93.4-1.81.8-1.81.81.8-1.8-1.6-1.0
Locomotion velocity, hab. session 13.24.55.6-2.42.3-2.32.32.2-2.1-2.1-1.0
Time in familiar zone, hab. session 20.50.51.20.7-0.70.7-0.7-0.60.51.10.2
Time in novel zone, hab. session 20.70.71.4-0.90.9-0.90.90.7-0.6-1.2-0.3
Total zone transitions, hab. session 20.20.20.3-0.50.5-0.50.50.5-0.4-0.3-0.4
Total locomotion distance, hab. session 20.50.60.8-0.90.9-0.90.90.8-0.8-0.6-0.4
Locomotion velocity, hab. session 20.70.91.1-1.01.0-1.01.01.0-1.0-0.8-0.6
Novel to familiar place preference ratio0.50.62.90.2-0.1-0.10.40.6-0.7-0.6-1.7
Novelty place preference0.50.52.80.2-0.2-0.00.40.6-0.6-0.6-1.7
Time in novel zone, NPP test0.50.52.90.2-0.2-0.10.30.6-0.6-0.7-1.7
Total zone transitions, NPP test0.40.50.9-1.01.0-0.90.70.6-0.5-0.60.3
Total locomotion distance, NPP test2.73.75.0-2.22.2-2.22.01.9-1.8-1.8-0.5
Locomotion velocity, NPP test2.12.94.3-2.12.1-2.01.91.6-1.6-1.5-0.2
Intraocular pressure0.10.21.00.3-0.30.2-0.00.1-0.30.3-1.0
Delta distance traveled before/after self-admin2.22.43.31.8-1.81.7-1.7-1.51.41.60.3
Delta ambulatory time before/after self-admin3.13.44.42.1-2.12.0-2.0-1.81.81.80.6
Parametrial fat weight0.50.95.3-0.20.10.1-0.7-0.80.80.52.3
Pavlov. Cond. lever latency0.20.20.40.6-0.60.5-0.4-0.30.40.1-0.4
Pavlov. Cond. magazine entry latency0.81.01.9-1.41.3-1.20.80.6-0.5-0.81.1
Pavlov. Cond. change in total contacts0.20.31.3-0.60.5-0.40.1-0.10.0-0.01.1
Pavlov. Cond. index score0.81.01.9-1.41.4-1.20.90.8-0.8-0.90.6
Pavlov. Cond. latency score0.50.71.3-1.21.1-1.00.60.5-0.6-0.60.8
Pavlov. Cond. lever contacts0.50.61.2-1.11.1-0.90.70.6-0.6-0.50.6
Pavlov. Cond. magazine entry number0.20.31.20.6-0.50.4-0.10.0-0.10.3-1.1
Pavlov. Cond. intertrial magazine entries0.20.30.4-0.50.5-0.50.50.5-0.5-0.5-0.7
Pavlov. Cond. lever-magazine prob. diff.0.81.01.8-1.41.3-1.20.80.7-0.7-0.90.6
Pavlov. Cond. response bias0.40.51.0-1.01.0-0.80.50.3-0.2-0.61.0
Pavlov. Cond. lever latency0.81.12.01.4-1.41.3-1.0-0.80.80.7-0.4
Pavlov. Cond. magazine entry latency0.40.40.8-0.90.9-0.80.60.4-0.3-0.60.5
Pavlov. Cond. change in total contacts0.10.10.4-0.50.5-0.40.20.1-0.10.00.6
Pavlov. Cond. index score0.91.22.1-1.51.4-1.31.10.8-0.8-1.00.4
Pavlov. Cond. latency score1.01.22.1-1.41.4-1.31.10.8-0.8-1.00.4
Pavlov. Cond. lever contacts0.50.71.3-1.11.1-1.00.70.5-0.5-0.50.6
Pavlov. Cond. magazine entry number2.32.84.52.1-2.12.0-1.7-1.41.21.7-0.3
Pavlov. Cond. intertrial magazine entries0.70.91.61.2-1.21.1-0.9-0.70.60.8-0.4
Pavlov. Cond. lever-magazine prob. diff.1.01.22.2-1.51.4-1.31.10.8-0.8-1.00.4
Pavlov. Cond. response bias0.81.12.0-1.41.4-1.31.00.7-0.6-0.90.7
Time in closed arm before self-admin0.10.10.70.1-0.1-0.00.20.3-0.3-0.4-0.9
Time in closed arm after self-admin0.70.71.6-0.70.8-0.81.10.7-0.4-1.3-0.7
Time in open arm before self-admin0.10.10.10.4-0.40.3-0.2-0.20.2-0.0-0.3
Time in open arm after self-admin0.91.02.11.0-1.11.0-1.1-0.80.51.40.3
Bone: periosteal estimation2.34.85.32.1-2.12.2-2.2-2.32.22.32.0
Bone: periosteal perimeter3.15.25.62.3-2.32.4-2.3-2.42.32.41.8
Bone: post-yield work0.40.51.10.6-0.60.6-0.7-0.80.70.71.0
Progressive ratio test 1 active lever presses0.10.10.20.3-0.30.3-0.2-0.10.20.2-0.5
Progressive ratio test 1 breakpoint0.10.10.20.4-0.40.3-0.2-0.10.20.2-0.5
Progressive ratio test 1 inactive lever presses1.81.93.01.6-1.61.5-1.6-1.20.91.70.2
Progressive ratio test 2 active lever presses0.00.00.10.2-0.20.10.00.00.10.0-0.4
Progressive ratio test 2 breakpoint0.00.00.10.1-0.10.10.00.0-0.0-0.0-0.2
Progressive ratio test 2 inactive lever presses0.00.10.10.3-0.20.10.00.2-0.3-0.1-0.4
Incentive Sensitization - Responses0.20.20.30.6-0.50.5-0.5-0.40.30.40.1
Incentive Sensitization - Breakpoint0.10.10.20.4-0.40.4-0.4-0.30.20.30.1
Sum of active levers in priming session hrs 5-60.10.10.60.0-0.1-0.00.10.2-0.30.2-0.7
Progressive ratio0.81.01.30.8-0.90.9-1.2-1.11.10.91.0
Food seeking constrained by brief footshock0.20.30.6-0.70.7-0.60.40.2-0.2-0.30.6
Seeking ratio, punishment vs. effort1.11.41.8-1.31.3-1.31.31.2-1.2-1.0-0.5
Retroperitoneal fat weight0.61.92.41.3-1.31.4-1.6-1.41.21.51.3
Reaction time number correct1.01.42.61.6-1.61.4-1.0-1.01.11.0-0.3
Reaction time mean minus median0.50.62.00.3-0.30.5-0.7-0.90.90.51.4
Reaction time mean minus median AUC0.40.51.20.5-0.50.6-0.7-0.90.70.71.1
Reaction time num false alarms0.10.20.8-0.10.10.10.0-0.30.60.20.9
Reaction time num false alarms AUC0.30.41.70.0-0.00.2-0.2-0.50.80.41.3
Reaction time trials correct on left1.01.42.61.6-1.61.4-1.0-1.01.11.0-0.3
Reaction time trials on left1.01.42.61.6-1.61.4-1.0-1.11.11.0-0.2
Reaction time mean0.20.30.5-0.70.7-0.60.40.2-0.2-0.40.7
Reaction time mean AUC0.30.50.8-0.90.9-0.80.50.4-0.4-0.60.6
Median of all reaction times0.20.30.6-0.80.7-0.70.50.4-0.5-0.50.3
Reaction time omissions1.31.83.70.9-1.01.1-1.4-1.51.41.11.9
Reaction time false alarm rate0.30.41.7-0.70.7-0.50.20.00.1-0.11.3
Reaction time premature initiation rate0.40.63.4-0.60.6-0.3-0.1-0.30.6-0.21.8
Reaction time premature initiations0.50.72.80.2-0.20.4-0.6-0.81.10.31.7
Std. dev. reaction times0.50.73.60.1-0.10.3-0.6-0.90.90.41.9
Reaction time trials completed1.01.42.61.6-1.61.4-1.0-1.11.11.0-0.2
Reaction time trials AUC0.91.32.31.5-1.51.4-0.9-1.01.01.0-0.4
Run reversals in cocaine runway, females1.00.92.8-0.50.5-0.70.91.0-0.9-1.0-1.7
Run reversals in cocaine runway, males2.52.53.7-1.91.9-1.81.61.5-1.5-1.4-0.3
Latency to leave start box in cocaine runway3.84.25.72.4-2.42.3-2.0-2.12.01.90.8
Latency to leave start box in cocaine runway, F4.44.96.82.6-2.62.5-2.2-2.12.12.20.6
Latency to leave start box in cocaine runway, M0.70.61.20.8-0.80.8-0.7-0.91.10.30.8
Std. dev. time between licks in bursts0.30.40.5-0.60.6-0.60.70.7-0.7-0.6-0.7
Total sessions with >9 infusions0.20.20.5-0.40.4-0.40.70.5-0.4-0.3-0.7
Short access day 1 total inactive lever presses1.82.03.41.8-1.91.7-1.5-0.90.51.7-0.8
Short access day 10 total inactive lever presses0.10.10.30.0-0.00.0-0.30.1-0.60.2-0.2
Short access day 1 total infusions0.70.71.3-0.70.7-0.80.91.0-1.1-0.4-1.0
Short access day 10 total infusions0.10.10.2-0.40.4-0.40.30.2-0.2-0.20.1
Short access total infusions0.10.10.3-0.30.3-0.30.40.4-0.50.1-0.4
Short access day 1 locomotion0.10.10.50.4-0.40.30.10.1-0.00.1-0.7
Short access day 10 total locomotion0.10.20.4-0.30.3-0.30.40.4-0.4-0.3-0.6
Short access total locomotion0.20.21.3-0.20.2-0.20.50.4-0.3-0.2-1.1
One hour access (0.3 mA shock)0.60.70.80.9-0.90.9-0.7-0.80.80.80.6
Compulsive drug intake3.53.54.81.7-1.71.8-2.2-1.91.72.21.7
One hour access (shock baseline)0.20.20.30.5-0.50.5-0.1-0.50.60.40.5
Social response proportion1.31.42.51.6-1.61.4-1.4-0.90.81.0-0.2
Social responses1.21.62.11.3-1.31.3-1.4-1.21.11.50.8
Social time0.00.10.3-0.20.2-0.20.1-0.00.10.10.5
Soleus weight0.72.02.71.7-1.71.6-1.5-1.41.31.30.8
Bone: stiffness0.20.41.40.2-0.30.4-0.5-0.70.70.51.2
Tibialis anterior weight0.20.91.21.1-1.11.0-1.0-0.91.00.70.3
Time to tail flick, vehicle, before self-admin0.60.61.1-0.40.4-0.60.70.9-0.9-0.8-1.1
Time to tail flick, vehicle, after self-admin0.20.30.40.6-0.60.6-0.5-0.50.50.50.0
Time to tail flick, test, before self-admin0.70.70.90.9-0.90.9-1.0-0.80.70.90.3
Time to tail flick, test, after self-admin0.70.71.21.1-1.11.0-0.6-0.60.70.9-0.6
Delta time to tail flick, vehicle, before/after SA0.30.30.50.5-0.50.5-0.6-0.60.70.60.4
Delta time to tail flick, test, before/after SA0.00.00.20.1-0.00.00.30.1-0.0-0.1-0.4
Tibia length0.10.21.5-0.10.00.1-0.3-0.40.40.11.2
Ambulatory time before self-admin0.20.20.4-0.20.2-0.30.70.4-0.3-0.6-0.5
Ambulatory time after self-admin0.40.51.11.1-1.00.9-0.5-0.50.50.3-0.5
Bone: tissue strength0.20.20.30.3-0.40.4-0.5-0.40.40.50.4
Total heroin consumption0.30.30.6-0.60.6-0.50.30.4-0.80.70.2
Bone: trabecular number0.71.01.61.3-1.21.2-1.0-0.90.81.10.1
Bone: trabecular spacing0.20.30.9-0.70.7-0.50.30.10.0-0.41.0
Bone: trabecular thickness1.21.42.01.2-1.21.2-1.2-1.21.31.40.8
Bone: trabecular tissue density0.60.81.21.1-1.11.1-0.9-0.90.80.90.2
Water consumed over 24 hours0.30.40.8-0.40.4-0.50.60.6-0.6-0.7-0.9
Number of responses in last shaping day0.10.10.20.4-0.40.4-0.2-0.20.30.2-0.3