Hub : Genes

Pde7a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Pde7a 0.03 0.02 3.8e-03 0.01 0.01 0 0.01 1.1e-02 6.7e-02 3.0e-01 2.7e-02
2 NAcc gene expression Pde7a 0.02 0.02 5.9e-03 0.01 0 0.01 0 3.2e-02 2.4e-01 6.6e-02 1.8e-01
3 Liver mRNA stability Pde7a 0.04 0.03 3.4e-03 0 0 0 0 7.4e-02 7.4e-02 3.1e-01 1.8e-01
4 Adipose mRNA stability Pde7a 0.17 0.09 4.8e-15 0.1 0.09 0.1 0.09 3.6e-11 3.6e-10 7.1e-11 2.7e-10
5 Brain gene expression Pde7a 0.05 0.03 4.6e-03 0.03 0 0.01 0.02 1.1e-03 9.6e-02 1.7e-02 8.0e-03
6 Adipose alternative polyA XM_006232188.4 0.03 0.02 9.6e-04 0.01 0.01 0.01 0.01 2.8e-02 8.7e-03 1.7e-02 3.6e-02
7 Adipose alternative polyA NM_031080.1 0.03 0.02 1.1e-03 0.01 0.01 0.01 0 5.9e-02 1.8e-02 2.4e-02 7.8e-02
8 Adipose alternative polyA XM_006232188.4 0.03 0.02 8.8e-04 0.01 0.01 0.01 0.01 5.3e-02 1.5e-02 1.7e-02 6.5e-02
9 Liver gene expression Pde7a 0.11 0.06 1.1e-11 0.07 0.07 0.07 0.07 4.8e-08 1.6e-08 5.6e-08 1.4e-08
10 Adipose isoform ratio XM_006232188.4 0.03 0.02 2.9e-03 0 0.01 0 0 9.5e-02 2.4e-02 1.0e-01 7.9e-02
11 PL gene expression Pde7a 0.06 0.07 2.8e-03 0.01 0.01 0.01 0 1.7e-02 4.9e-02 8.5e-03 8.9e-02
12 Adipose gene expression Pde7a 0.1 0.05 1.4e-11 0.07 0.08 0.08 0.08 1.3e-08 1.6e-09 2.4e-09 1.5e-09
13 NAcc isoform ratio NM_031080.1 0.04 0.03 3.6e-03 0.02 0.02 0.02 0.02 9.3e-04 2.7e-03 2.5e-03 7.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.52.44.01.6-1.2-1.8-1.9-2.0-1.71.5-1.51.7-1.7-1.01.40.1
Area under the delay curve0.20.21.1-0.20.40.10.40.40.2-0.30.3-0.30.21.10.00.5
BMI with tail1.13.56.2-1.62.32.32.52.41.7-1.51.5-1.81.62.0-1.1-1.3
BMI without tail2.65.38.4-2.62.92.82.62.52.3-2.22.2-2.22.12.2-1.6-1.1
Body weight1.45.910.0-1.92.32.73.23.12.5-2.32.3-2.72.52.4-2.1-0.2
Weight adjusted by age0.50.51.2-0.20.10.50.80.80.8-0.70.7-0.90.90.5-1.10.8
Bone surface0.20.40.80.9-0.6-0.6-0.6-0.7-0.60.6-0.60.7-0.7-0.50.6-0.2
Bone volume0.20.40.80.9-0.6-0.6-0.7-0.8-0.60.5-0.50.6-0.6-0.60.4-0.1
Breakpoint value in progressive ratio session0.30.31.7-1.31.20.60.1-0.00.3-0.30.3-0.10.2-0.3-0.2-0.8
Number of licking bursts1.41.62.2-1.11.11.41.51.51.4-1.31.3-1.41.50.6-1.40.2
Context. condit. distance diff. score0.30.42.00.2-0.6-0.10.60.60.3-0.30.3-0.60.51.0-0.41.4
Locomotion velocity, session 10.30.30.9-0.30.40.40.60.60.6-0.60.6-0.60.51.0-0.40.4
Locomotion distance, session 10.20.31.20.1-0.0-0.1-0.0-0.1-0.60.6-0.60.5-0.70.20.9-1.1
Locomotion velocity, session 21.51.83.0-1.11.41.41.61.51.4-1.41.4-1.41.21.7-0.9-0.2
Locomotion distance, session 20.30.41.20.7-0.1-0.3-0.0-0.1-0.70.8-0.90.6-0.80.31.1-0.9
Locomotion velocity, session 30.91.01.8-0.71.11.01.31.31.0-1.01.0-1.11.01.3-0.70.2
Locomotion distance, session 30.80.92.2-0.51.00.61.11.10.9-0.90.9-1.10.91.5-0.80.8
Stereotopy head waving bouts, day 30.20.20.60.5-0.7-0.5-0.3-0.5-0.40.4-0.40.3-0.3-0.60.20.2
Stereotopy head waving duration, day 30.50.62.50.3-0.5-0.3-0.8-0.9-0.70.7-0.70.8-0.6-1.60.5-1.0
Locomotion velocity, session 72.83.15.52.3-2.3-1.8-1.7-1.6-1.81.9-1.91.8-1.7-1.51.5-0.0
Locomotion distance, session 72.33.04.12.0-2.0-1.8-2.0-1.9-1.71.7-1.71.7-1.6-2.01.20.3
Stereotopy head waving bouts, day 70.30.40.8-0.40.30.40.80.70.6-0.60.6-0.70.60.9-0.50.6
Stereotopy head waving duration, day 70.50.60.7-0.80.60.70.80.80.8-0.90.9-0.80.80.9-0.70.4
Locomotion velocity, session 80.70.93.3-0.60.70.71.31.30.8-0.70.8-1.00.71.8-0.40.3
Locomotion distance, session 80.71.02.7-0.50.60.91.51.50.9-0.80.8-1.10.91.7-0.50.3
Degree of sensitization distance4.74.79.41.8-2.2-1.7-2.6-2.6-2.12.1-2.12.4-2.1-3.11.7-1.2
Degree of sensitization stereotypy2.22.54.9-1.21.21.21.91.91.6-1.61.6-1.71.62.2-1.31.1
Conditioned locomotion2.02.33.01.5-1.6-1.7-1.5-1.5-1.71.7-1.71.6-1.7-0.51.70.0
Cocaine response after cond. corrected0.10.11.1-0.0-0.40.0-0.3-0.40.1-0.20.2-0.00.2-1.0-0.50.1
Cocaine response after cond. not corrected0.10.21.2-0.1-0.30.0-0.3-0.40.2-0.20.2-0.00.3-1.1-0.60.2
Cocaine response before conditioning0.20.30.40.4-0.2-0.3-0.5-0.5-0.60.6-0.60.6-0.6-0.50.6-0.6
Saline control response0.50.61.2-1.01.11.11.01.00.8-0.60.6-0.70.70.3-0.5-0.6
Bone: connectivity density1.72.65.11.1-0.9-1.8-2.2-2.3-1.81.5-1.51.9-1.9-1.01.7-0.4
Bone: cortical apparent density1.62.13.7-1.31.31.01.41.51.5-1.61.6-1.61.51.9-1.41.2
Bone: cortical area0.30.42.51.6-1.0-0.10.80.70.10.2-0.2-0.40.30.0-0.30.8
Bone: cortical porosity1.01.11.81.0-1.0-0.7-0.7-0.7-1.21.3-1.41.2-1.2-0.91.3-0.9
Bone: cortical porosity0.70.71.31.1-1.1-0.7-0.4-0.4-0.91.1-1.10.9-0.9-0.41.1-0.4
Bone: cortical thickness1.21.98.32.9-2.2-1.5-0.2-0.3-1.11.4-1.40.6-0.9-0.20.81.4
Bone: cortical thickness0.20.20.90.9-0.50.10.80.60.10.1-0.1-0.30.10.60.10.1
Bone: cortical tissue density1.92.54.1-1.51.51.21.51.51.7-1.81.8-1.81.62.0-1.51.2
Condit. Reinf. active minus inactive responses0.20.21.80.2-0.10.30.10.1-0.30.4-0.40.3-0.4-0.20.6-1.3
Condit. Reinf. active-inactive response ratio0.10.21.00.2-0.10.1-0.3-0.3-0.30.3-0.30.4-0.3-0.50.4-1.0
Condit. Reinf. active responses0.10.10.60.3-0.10.30.40.4-0.00.1-0.1-0.0-0.10.60.4-0.8
Condit. Reinf. inactive responses0.30.30.9-0.20.10.70.90.80.5-0.50.5-0.70.50.9-0.2-0.2
Incentive salience index mean0.10.20.9-0.30.30.70.50.50.3-0.20.2-0.20.20.10.0-1.0
Condit. Reinf. lever presses0.50.61.3-1.10.90.90.60.60.9-1.01.0-0.80.80.5-0.7-0.3
Condit. Reinf. active minus inactive responses0.10.10.60.2-0.2-0.30.30.4-0.20.3-0.3-0.0-0.10.80.30.5
Condit. Reinf. active-inactive response ratio0.20.21.50.3-0.1-0.50.20.2-0.20.2-0.2-0.0-0.21.20.40.9
Condit. Reinf. active responses0.10.10.40.5-0.4-0.20.10.1-0.40.6-0.60.3-0.3-0.20.4-0.3
Condit. Reinf. inactive responses0.20.21.40.3-0.30.30.10.1-0.00.3-0.30.10.1-1.2-0.2-0.8
Condit. Reinf. lever presses0.20.31.00.3-0.1-0.2-0.5-0.4-0.50.6-0.60.6-0.4-1.00.3-0.6
Condit. Reinf. lever reinforcers received0.10.10.40.5-0.3-0.20.10.1-0.40.6-0.60.4-0.3-0.20.4-0.3
Conditioned reinforcement - actives0.20.20.40.2-0.3-0.5-0.6-0.6-0.60.5-0.50.5-0.7-0.30.3-0.1
Conditioned reinforcement - inactives0.30.30.8-0.60.50.4-0.1-0.10.6-0.90.9-0.40.5-0.5-0.90.2
Conditioned locomotion0.91.11.7-0.50.60.80.90.91.1-1.31.3-1.31.10.9-1.21.0
Patch foraging indifference point 0 sec0.61.02.3-0.70.60.40.70.61.1-1.21.2-1.21.10.6-1.41.5
Patch foraging indifference point AUC0.20.21.5-0.10.3-0.10.20.3-0.20.2-0.20.1-0.31.20.6-0.2
Delay disc. indifference point, 0s delay0.20.20.60.5-0.8-0.40.30.3-0.30.4-0.40.0-0.20.60.50.4
Delay disc. indifference point, 16s delay0.30.30.70.6-0.2-0.6-0.4-0.4-0.60.5-0.50.5-0.60.30.80.1
Delay disc. indifference point, 2s delay0.20.21.10.3-0.2-0.10.40.40.3-0.40.4-0.50.40.7-0.41.0
Delay disc. indifference point, 24s delay1.41.42.21.4-1.4-1.5-1.3-1.3-1.21.1-1.11.1-1.2-0.61.10.6
Delay disc. indifference point, 4s delay1.71.83.6-1.81.71.31.31.31.3-1.31.3-1.21.11.9-0.7-0.2
Delay disc. indifference point, 8s delay0.30.30.9-0.50.80.40.50.50.5-0.60.6-0.50.40.9-0.30.3
Indifference point function ln k1.82.54.0-1.91.91.61.01.01.8-2.02.0-1.61.70.3-2.00.2
Indifference point function log k1.82.54.0-1.91.91.61.01.01.8-2.02.0-1.61.70.3-2.00.2
Patch foraging total patch changes 0 sec1.32.03.4-1.31.10.91.21.11.6-1.71.7-1.61.60.9-1.81.5
Patch foraging total patch changes 12 sec0.10.10.80.1-0.2-0.40.20.2-0.10.1-0.1-0.2-0.00.8-0.10.9
Patch foraging total patch changes 18 sec0.20.21.4-0.20.30.10.60.60.2-0.20.2-0.40.21.2-0.10.4
Patch foraging total patch changes 24 sec0.00.00.10.1-0.2-0.3-0.2-0.2-0.20.1-0.10.1-0.20.30.10.1
Patch foraging total patch changes 6 sec0.91.31.7-1.21.21.01.11.01.2-1.21.2-1.31.11.3-1.20.5
Patch foraging time to switch 0 sec0.00.10.40.0-0.30.10.0-0.0-0.10.2-0.20.2-0.1-0.50.2-0.6
Patch foraging water rate 0 sec0.30.41.3-0.60.90.10.30.30.5-0.70.7-0.60.51.2-0.51.0
Patch foraging water rate 12 sec0.30.40.80.9-0.5-0.4-0.7-0.6-0.70.7-0.70.7-0.7-0.60.6-0.6
Patch foraging water rate 18 sec0.10.20.40.6-0.5-0.2-0.5-0.5-0.40.3-0.30.3-0.4-0.60.1-0.3
Patch foraging water rate 24 sec0.20.20.40.7-0.4-0.7-0.4-0.5-0.50.4-0.30.4-0.50.50.50.4
Patch foraging water rate 6 sec0.91.32.3-1.01.21.10.80.91.4-1.51.5-1.21.40.5-1.50.5
Seeking ratio, delayed vs. immediate footshock2.73.15.02.0-2.2-2.2-2.2-2.2-1.61.5-1.41.5-1.5-1.70.81.3
Distance traveled before self-admin2.82.94.3-1.41.81.92.02.11.8-1.71.7-1.91.81.5-1.7-0.0
Distance traveled after self-admin4.65.17.7-1.82.12.62.42.32.6-2.52.5-2.52.70.6-2.8-0.0
Extensor digitorum longus weight5.019.928.3-4.74.74.75.35.24.6-4.44.4-4.74.34.8-3.4-0.2
Bone: elastic displacement2.32.64.91.7-1.6-2.2-1.7-1.7-1.81.6-1.61.5-1.7-0.21.51.2
Bone: elastic work0.70.91.71.3-1.1-1.3-1.0-1.0-0.90.8-0.80.7-0.8-0.10.61.1
Bone: endosteal estimation1.12.44.8-2.01.82.21.71.71.5-1.21.2-1.21.40.3-1.0-1.7
Bone: endosteal perimeter1.42.84.5-1.31.42.01.91.91.9-1.71.7-1.92.10.3-2.10.1
Epididymis fat weight2.35.37.4-1.51.72.22.72.72.6-2.52.5-2.72.71.9-2.51.1
Delta time in closed arm before/after self-admin0.40.41.60.4-0.1-0.1-0.4-0.4-0.60.6-0.60.7-0.7-0.21.0-1.2
Delta time in open arm before/after self-admin0.10.11.10.1-0.2-0.30.10.20.1-0.10.1-0.20.20.3-0.41.0
Diff in mean of infusions in LGA sessions0.20.20.6-0.3-0.0-0.3-0.7-0.7-0.40.3-0.30.6-0.4-0.80.4-0.4
Delay discount exponential model param0.20.20.90.3-0.4-0.1-0.4-0.4-0.30.4-0.40.4-0.3-0.90.1-0.5
Extinction: sum of active levers before priming0.20.20.60.8-0.3-0.6-0.4-0.4-0.50.5-0.50.5-0.4-0.20.30.3
Active lever presses in extinction session 60.80.76.2-0.10.50.70.30.3-0.40.7-0.70.5-0.4-0.60.7-2.5
Bone: final force0.30.51.70.30.31.01.31.20.5-0.10.1-0.60.50.3-0.2-1.0
Bone: final moment0.30.41.50.40.10.91.21.10.4-0.10.0-0.50.50.2-0.1-0.9
Food consumed during 24 hour testing period3.64.46.7-2.22.42.62.42.42.2-2.12.1-2.12.11.6-1.7-0.8
Glucose0.30.51.3-0.40.61.01.11.10.4-0.20.2-0.50.40.7-0.0-1.0
Heart weight0.20.32.30.6-0.5-0.8-0.7-0.6-0.1-0.10.10.1-0.10.2-0.11.5
Delay discount hyperbolic model param0.20.21.00.4-0.5-0.2-0.5-0.5-0.40.4-0.50.5-0.3-1.00.2-0.4
Intermittent access intake day 1-15 change0.90.92.1-0.50.71.01.31.31.0-0.90.9-1.10.91.4-0.80.1
Intermittent access intake escalation0.70.71.3-0.50.71.11.11.10.7-0.60.6-0.70.61.1-0.4-0.9
Intermittent access intake escalation 21.21.22.3-0.61.01.31.51.51.1-1.01.0-1.11.01.4-0.7-0.5
Intermitt. access day 1 inactive lever presses0.80.97.0-0.10.30.6-0.5-0.5-0.40.4-0.40.6-0.6-1.40.5-2.6
Intermitt. access day 15 inactive lever presses1.11.23.70.0-0.1-0.4-0.9-0.9-1.21.2-1.21.2-1.4-0.61.4-1.9
Intermitt. access escalation Index0.20.11.20.00.00.1-0.5-0.5-0.0-0.10.10.2-0.0-1.1-0.3-0.4
Intermittent access day 1 total infusions0.20.30.7-0.1-0.0-0.6-0.5-0.5-0.60.5-0.40.4-0.80.40.70.1
Intermittent access day 15 total infusions0.20.30.8-0.10.1-0.1-0.0-0.0-0.50.4-0.40.3-0.80.90.8-0.8
Intermittent access terminal intake (last 3 days)0.70.74.0-0.90.90.60.90.90.1-0.10.1-0.3-0.32.00.6-1.1
Intermittent access total infusions0.40.41.2-0.20.1-0.4-0.4-0.4-0.80.6-0.60.5-1.10.81.0-0.6
Intermittent access day 1 locomotion0.40.42.1-0.40.40.00.60.60.3-0.40.4-0.70.31.4-0.21.0
Intermittent access day 15 total locomotion1.51.62.9-1.21.41.11.41.41.2-1.31.3-1.51.11.7-1.10.5
Intermittent access total locomotion0.40.52.5-0.60.70.40.80.80.4-0.50.5-0.70.31.6-0.20.3
Intermittent access standard deviation1.21.33.3-1.11.11.21.41.41.0-1.01.0-1.10.81.8-0.6-0.4
Left kidney weight0.10.32.0-0.20.3-0.3-0.0-0.00.4-0.60.6-0.50.30.7-0.51.4
Right kidney weight0.41.12.6-0.40.70.41.11.10.9-1.01.0-1.21.01.6-0.81.5
Cocaine induced anxiety0.40.51.10.7-0.7-0.5-0.2-0.2-0.81.0-1.00.7-0.8-0.11.0-0.7
Post-drug Anxiety0.50.50.90.6-0.6-0.6-0.6-0.6-0.80.9-0.90.8-0.8-0.51.0-0.5
Baseline Anxiety0.40.51.0-0.60.60.3-0.0-0.10.7-1.01.0-0.70.70.0-1.00.9
Tail length1.13.44.4-1.81.71.81.91.82.1-2.12.1-2.12.11.3-2.00.7
Length with tail0.72.74.3-0.80.81.31.81.81.8-1.81.8-2.02.01.1-2.11.5
Length without tail0.20.52.51.3-0.9-0.40.50.50.10.0-0.0-0.50.40.3-0.61.6
Times rat made contact with spout3.33.85.8-1.51.52.32.22.22.3-2.12.0-2.22.40.4-2.40.2
Lifetime Intake0.50.51.50.0-0.1-0.6-0.5-0.5-0.90.8-0.80.7-1.20.71.2-0.6
Liver weight, left1.93.15.1-1.71.72.22.22.31.8-1.61.6-1.81.71.5-1.3-1.0
Liver weight, right1.32.24.5-2.02.12.01.81.71.2-1.01.0-1.21.01.2-0.7-1.8
Locomotor activity0.40.61.1-0.90.81.01.11.00.8-0.70.7-0.80.80.5-0.7-0.5
Locomotor testing distance0.50.81.9-0.80.91.11.41.30.9-0.70.7-0.90.90.6-0.7-0.4
Locomotor testing rearing0.20.21.10.4-0.70.00.1-0.1-0.30.6-0.60.4-0.2-1.00.2-0.7
Locomotion in novel chamber0.20.20.6-0.00.00.20.70.80.4-0.30.3-0.40.40.6-0.10.6
Locomotion in novel chamber post-restriction0.91.02.20.5-0.4-0.7-1.1-1.1-1.11.1-1.11.3-1.2-0.71.5-1.0
Fecal boli incidents, locomotor time 11.71.88.30.5-0.3-0.0-0.7-0.7-1.21.4-1.51.5-1.3-1.21.8-2.9
Change in fecal boli incidents, locomotor task2.32.26.02.5-2.4-2.0-1.0-1.0-1.11.1-1.10.7-0.8-0.60.42.3
Time >=10cm from walls, locomotor time 10.50.51.11.0-0.9-0.5-0.6-0.6-0.60.7-0.70.6-0.6-1.00.3-0.2
Bouts of movement, locomotor time 10.20.20.4-0.20.2-0.5-0.6-0.6-0.40.2-0.20.4-0.50.50.60.2
Total resting periods, locomotor time 10.20.20.5-0.30.2-0.6-0.7-0.7-0.40.2-0.20.4-0.50.50.60.4
Rest time, locomotor task time 10.70.73.2-1.31.60.80.40.40.1-0.00.00.1-0.10.70.8-1.8
Distance moved, locomotor task time 10.70.73.00.4-0.50.40.20.20.8-0.80.8-0.71.1-1.2-1.70.9
Vertical activity count, locomotor time 11.61.65.5-0.40.41.00.70.71.5-1.61.6-1.31.7-0.9-2.30.8
Time >=10cm from walls, locomotor time 21.11.12.01.4-1.2-1.1-0.7-0.7-1.21.3-1.31.0-1.0-1.00.90.2
Bouts of movement, locomotor time 20.40.41.0-0.10.0-0.9-0.6-0.6-0.60.4-0.40.5-0.71.00.80.7
Total resting periods, locomotor time 20.30.31.3-0.30.2-0.7-0.5-0.5-0.50.3-0.20.4-0.61.20.80.6
Rest time, locomotor task time 20.80.94.8-1.21.20.2-0.5-0.5-0.60.5-0.50.8-0.80.51.2-2.2
Distance moved, locomotor task time 20.30.42.80.8-0.8-0.2-0.4-0.40.00.0-0.00.10.2-1.7-0.60.4
Vertical activity count, locomotor time 21.21.32.4-1.21.41.60.70.71.3-1.31.3-0.91.3-0.7-1.4-0.8
Light reinforcement 10.61.11.5-0.80.60.81.21.21.1-1.11.1-1.21.21.1-1.10.8
Light reinforcement 24.86.411.3-1.61.12.02.42.42.9-3.03.0-3.03.11.2-3.42.3
Bone: marrow area1.12.44.9-2.11.92.21.61.71.5-1.31.2-1.21.40.3-1.0-1.8
Bone: maximum diameter0.30.51.20.5-0.00.71.11.10.7-0.50.5-0.90.9-0.2-1.00.3
Bone: maximum force0.40.72.0-0.20.81.31.41.30.6-0.30.3-0.70.70.1-0.3-1.4
Bone: maximum moment0.40.62.1-0.10.61.21.31.20.5-0.20.1-0.50.5-0.0-0.2-1.5
Mean time between licks in bursts0.91.33.2-1.71.81.50.80.81.0-1.11.1-0.80.80.5-0.7-1.4
Mean num. licks in bursts0.10.10.30.2-0.2-0.0-0.2-0.2-0.20.3-0.30.3-0.2-0.60.1-0.4
Cd content in liver0.30.31.5-0.40.90.40.80.80.3-0.30.3-0.50.31.2-0.00.1
Co content in liver1.41.73.6-1.51.31.91.21.31.3-1.11.1-1.01.4-0.7-1.3-1.3
Cu content in liver0.00.00.10.3-0.3-0.2-0.1-0.1-0.10.2-0.20.1-0.1-0.30.00.1
Fe content in liver0.40.50.90.8-0.8-0.5-0.4-0.4-0.70.9-0.90.8-0.7-0.61.0-0.6
K content in liver0.30.30.90.2-0.6-0.4-0.8-0.8-0.40.3-0.30.5-0.3-0.90.1-0.1
Mg content in liver0.30.30.90.2-0.3-0.9-0.9-0.9-0.60.4-0.40.5-0.5-0.50.30.6
Mn content in liver0.10.20.30.3-0.1-0.3-0.4-0.4-0.40.4-0.40.5-0.5-0.10.6-0.3
Na content in liver1.01.12.6-0.30.10.50.91.01.1-1.11.1-1.21.20.9-1.41.6
Rb content in liver1.72.23.41.3-1.2-1.1-1.2-1.3-1.71.8-1.81.6-1.6-1.41.7-1.2
Se content in liver0.40.40.80.9-0.6-0.7-0.6-0.5-0.70.8-0.80.7-0.6-0.50.60.1
Sr content in liver0.60.51.40.0-0.2-0.7-1.2-1.1-0.80.6-0.60.9-1.0-0.60.7-0.1
Zn content in liver0.10.10.4-0.60.5-0.0-0.5-0.50.1-0.20.20.10.0-0.4-0.30.2
Bone: minimum diameter0.30.61.1-0.40.61.00.90.90.9-0.70.7-0.81.0-0.4-1.0-0.3
Time in familiar zone, hab. session 10.40.42.3-0.40.00.5-0.4-0.40.00.0-0.00.30.0-1.5-0.2-1.4
Time in novel zone, hab. session 10.40.42.0-0.10.2-0.10.60.60.3-0.40.4-0.60.31.4-0.21.3
Total zone transitions, hab. session 10.10.21.10.6-0.2-0.50.00.0-0.20.1-0.1-0.1-0.21.00.20.9
Total locomotion distance, hab. session 10.20.31.40.6-0.1-0.60.00.2-0.20.1-0.1-0.1-0.21.20.21.1
Locomotion velocity, hab. session 10.20.31.70.20.2-0.30.20.40.1-0.20.2-0.40.11.3-0.11.2
Time in familiar zone, hab. session 20.40.43.10.2-0.5-0.0-0.8-0.7-0.20.2-0.20.5-0.2-1.8-0.1-0.7
Time in novel zone, hab. session 20.30.30.90.4-0.2-0.6-0.3-0.4-0.70.7-0.70.6-0.80.50.9-0.2
Total zone transitions, hab. session 20.20.31.1-0.10.50.30.70.70.4-0.40.4-0.60.41.1-0.30.5
Total locomotion distance, hab. session 20.10.10.30.4-0.1-0.30.20.1-0.10.1-0.1-0.1-0.10.60.10.6
Locomotion velocity, hab. session 20.10.21.10.3-0.1-0.30.40.20.1-0.10.1-0.40.10.8-0.11.1
Novel to familiar place preference ratio2.32.43.71.4-1.0-1.9-1.5-1.6-1.81.8-1.81.7-1.8-0.31.90.2
Novelty place preference2.02.03.31.4-1.0-1.8-1.4-1.5-1.71.6-1.61.5-1.7-0.31.70.4
Time in novel zone, NPP test1.61.62.51.2-0.8-1.6-1.3-1.3-1.51.5-1.41.4-1.5-0.31.60.2
Total zone transitions, NPP test0.10.20.70.2-0.0-0.4-0.0-0.1-0.60.6-0.60.4-0.60.50.8-0.3
Total locomotion distance, NPP test0.10.10.20.4-0.1-0.30.1-0.0-0.30.4-0.40.2-0.30.20.4-0.0
Locomotion velocity, NPP test0.40.50.80.9-0.6-0.9-0.5-0.6-0.90.9-0.90.7-0.9-0.10.90.1
Intraocular pressure0.50.71.5-0.70.90.91.01.00.8-0.80.8-0.80.71.2-0.4-0.1
Delta distance traveled before/after self-admin0.10.10.20.2-0.20.10.10.10.3-0.20.2-0.30.4-0.5-0.50.4
Delta ambulatory time before/after self-admin0.20.20.90.7-0.7-0.5-0.3-0.4-0.10.0-0.00.10.0-0.5-0.21.0
Parametrial fat weight3.77.19.8-1.82.22.63.13.03.0-2.92.9-3.13.02.2-2.80.9
Pavlov. Cond. lever latency0.40.51.51.2-1.0-0.9-0.2-0.2-0.60.7-0.70.4-0.50.30.50.9
Pavlov. Cond. magazine entry latency0.60.83.1-1.81.51.00.10.10.7-0.90.9-0.40.40.4-0.3-1.1
Pavlov. Cond. change in total contacts2.52.74.8-2.22.02.01.51.51.7-1.81.8-1.61.51.2-1.3-0.8
Pavlov. Cond. index score1.82.25.7-2.42.11.81.01.01.5-1.71.7-1.21.30.8-1.2-1.0
Pavlov. Cond. latency score1.21.54.0-2.01.71.60.80.81.2-1.21.2-0.91.00.4-0.8-1.3
Pavlov. Cond. lever contacts1.41.64.2-2.11.81.40.70.71.3-1.51.5-1.01.10.6-1.0-0.7
Pavlov. Cond. magazine entry number2.43.06.42.5-2.3-2.0-1.2-1.2-1.92.1-2.11.6-1.6-1.01.50.6
Pavlov. Cond. intertrial magazine entries0.81.02.91.7-1.7-1.3-0.4-0.5-0.80.7-0.70.5-0.70.40.71.5
Pavlov. Cond. lever-magazine prob. diff.2.63.37.5-2.72.42.11.31.31.9-2.02.0-1.61.61.0-1.5-1.0
Pavlov. Cond. response bias2.63.27.4-2.72.42.01.21.21.9-2.12.1-1.61.61.3-1.5-0.6
Pavlov. Cond. lever latency0.10.10.7-0.40.50.0-0.1-0.2-0.20.0-0.00.1-0.40.80.5-0.5
Pavlov. Cond. magazine entry latency0.20.20.4-0.40.40.60.10.20.5-0.50.5-0.30.5-0.4-0.6-0.3
Pavlov. Cond. change in total contacts0.20.31.11.0-0.7-0.5-0.2-0.2-0.50.7-0.70.5-0.4-0.60.30.2
Pavlov. Cond. index score0.10.10.30.00.00.30.20.30.4-0.30.3-0.20.5-0.5-0.50.1
Pavlov. Cond. latency score0.10.10.3-0.00.10.40.30.40.4-0.30.3-0.30.5-0.4-0.60.1
Pavlov. Cond. lever contacts0.10.21.10.6-0.7-0.2-0.1-0.0-0.20.3-0.30.20.1-1.0-0.20.3
Pavlov. Cond. magazine entry number0.10.10.3-0.1-0.0-0.3-0.1-0.2-0.20.1-0.10.0-0.30.60.20.4
Pavlov. Cond. intertrial magazine entries0.30.40.60.7-0.8-0.7-0.6-0.6-0.70.6-0.60.6-0.70.00.70.1
Pavlov. Cond. lever-magazine prob. diff.0.20.30.6-0.20.30.50.50.60.6-0.50.5-0.50.7-0.3-0.80.1
Pavlov. Cond. response bias0.10.10.90.5-0.6-0.1-0.00.0-0.10.2-0.20.20.1-0.9-0.20.1
Time in closed arm before self-admin0.10.10.2-0.20.4-0.0-0.2-0.20.2-0.30.3-0.20.1-0.1-0.40.4
Time in closed arm after self-admin0.30.31.2-0.50.80.7-0.2-0.30.3-0.40.4-0.00.2-0.8-0.3-1.1
Time in open arm before self-admin0.30.40.7-0.40.20.80.80.80.7-0.60.6-0.70.70.0-0.5-0.2
Time in open arm after self-admin0.40.51.2-0.2-0.00.41.11.10.6-0.50.5-0.80.71.0-0.50.7
Bone: periosteal estimation0.40.92.0-0.40.61.41.41.41.0-0.70.7-1.01.1-0.1-0.9-0.7
Bone: periosteal perimeter0.60.91.90.3-0.00.91.41.31.0-0.80.8-1.21.3-0.1-1.40.7
Bone: post-yield work1.21.68.5-1.31.52.01.01.10.9-0.60.6-0.40.7-0.4-0.3-2.9
Progressive ratio test 1 active lever presses0.40.51.7-1.00.60.40.70.70.5-0.60.6-0.70.31.3-0.30.3
Progressive ratio test 1 breakpoint0.40.41.6-1.00.60.40.70.60.5-0.50.6-0.70.31.3-0.30.2
Progressive ratio test 1 inactive lever presses0.70.81.10.6-0.7-0.6-1.0-1.1-0.90.9-0.90.9-1.0-1.10.7-0.9
Progressive ratio test 2 active lever presses0.50.51.20.3-0.4-0.8-0.6-0.6-0.90.8-0.80.6-1.10.51.0-0.1
Progressive ratio test 2 breakpoint0.10.11.00.1-0.1-0.4-0.0-0.1-0.30.1-0.1-0.0-0.41.00.30.4
Progressive ratio test 2 inactive lever presses0.30.31.1-0.00.1-0.2-0.3-0.3-0.60.5-0.50.5-0.90.41.0-1.0
Incentive Sensitization - Responses0.10.10.3-0.10.2-0.3-0.5-0.5-0.30.2-0.20.4-0.5-0.20.4-0.2
Incentive Sensitization - Breakpoint0.10.10.2-0.10.2-0.2-0.4-0.4-0.20.1-0.00.2-0.3-0.20.3-0.1
Sum of active levers in priming session hrs 5-60.80.71.3-1.11.11.10.90.80.9-0.90.9-0.80.90.3-0.7-0.4
Progressive ratio0.80.92.10.6-0.6-0.4-0.9-0.9-1.01.1-1.11.1-1.0-1.00.9-1.5
Food seeking constrained by brief footshock0.20.20.7-0.40.40.0-0.7-0.7-0.20.1-0.10.5-0.3-0.90.0-0.7
Seeking ratio, punishment vs. effort0.30.41.4-0.60.60.10.00.00.6-0.80.8-0.50.60.4-0.71.2
Retroperitoneal fat weight1.65.47.8-1.82.32.32.82.82.4-2.42.4-2.62.32.8-1.90.4
Reaction time number correct1.42.04.62.1-2.1-1.2-1.1-1.2-1.31.4-1.41.3-1.1-2.00.9-0.2
Reaction time mean minus median6.28.217.4-4.04.23.12.52.62.8-2.92.9-2.72.52.5-2.2-0.8
Reaction time mean minus median AUC5.67.314.9-3.83.93.02.42.52.6-2.72.7-2.52.32.6-2.0-1.0
Reaction time num false alarms3.24.49.83.1-2.7-2.0-1.7-1.7-2.22.4-2.41.9-2.0-1.71.7-0.1
Reaction time num false alarms AUC2.63.69.23.0-2.7-1.9-1.4-1.5-1.92.1-2.11.6-1.7-1.61.40.2
Reaction time trials correct on left1.42.04.62.1-2.1-1.2-1.1-1.2-1.31.4-1.41.3-1.1-2.00.9-0.2
Reaction time trials on left1.42.04.52.1-2.1-1.1-1.1-1.2-1.31.4-1.41.3-1.1-2.00.9-0.3
Reaction time mean1.42.05.6-2.42.31.81.11.21.2-1.11.1-1.01.00.7-0.7-1.6
Reaction time mean AUC1.21.65.2-2.32.11.60.80.91.0-1.01.0-0.80.80.4-0.6-1.6
Median of all reaction times0.50.62.5-1.41.21.00.40.50.4-0.30.3-0.20.3-0.1-0.1-1.6
Reaction time omissions1.21.63.0-1.51.61.71.51.51.2-1.11.0-1.11.10.7-0.7-1.2
Reaction time false alarm rate0.71.02.81.7-1.4-1.2-0.7-0.6-1.01.1-1.10.7-0.9-0.30.70.5
Reaction time premature initiation rate0.10.10.3-0.60.5-0.4-0.5-0.5-0.2-0.00.00.1-0.30.40.10.4
Reaction time premature initiations0.20.30.80.3-0.3-0.7-0.8-0.9-0.60.5-0.40.5-0.6-0.50.40.2
Std. dev. reaction times3.44.810.2-3.13.22.62.02.12.1-2.12.1-1.91.91.6-1.5-1.4
Reaction time trials completed1.42.04.52.1-2.1-1.1-1.1-1.2-1.31.4-1.41.3-1.1-2.00.9-0.3
Reaction time trials AUC1.21.74.22.1-2.0-1.0-0.9-1.1-1.21.3-1.31.2-1.0-1.80.9-0.3
Run reversals in cocaine runway, females5.85.67.3-2.32.22.52.42.42.7-2.72.7-2.62.71.5-2.70.5
Run reversals in cocaine runway, males1.01.03.3-1.81.71.30.60.60.6-0.50.5-0.30.40.4-0.1-1.8
Latency to leave start box in cocaine runway0.40.50.9-0.40.60.90.30.40.9-0.90.9-0.60.9-0.4-0.9-0.2
Latency to leave start box in cocaine runway, F0.20.30.6-0.60.70.80.20.20.5-0.50.5-0.20.4-0.3-0.3-0.7
Latency to leave start box in cocaine runway, M1.51.52.7-0.81.01.11.01.01.4-1.51.5-1.41.50.6-1.60.7
Std. dev. time between licks in bursts0.30.30.70.8-0.7-0.8-0.6-0.5-0.50.4-0.40.5-0.50.00.50.6
Total sessions with >9 infusions0.10.10.80.4-0.5-0.30.10.10.0-0.00.0-0.20.10.6-0.10.9
Short access day 1 total inactive lever presses0.70.81.80.8-1.0-1.0-1.2-1.2-0.80.7-0.70.8-0.7-1.30.30.5
Short access day 10 total inactive lever presses0.30.41.50.7-0.40.1-0.4-0.4-0.30.4-0.40.4-0.3-1.20.2-1.2
Short access day 1 total infusions0.80.91.6-0.80.60.91.21.21.0-0.90.9-1.10.91.3-0.80.2
Short access day 10 total infusions0.20.20.5-0.50.2-0.3-0.3-0.3-0.50.3-0.30.3-0.70.60.6-0.4
Short access total infusions0.10.21.1-0.0-0.1-0.4-0.0-0.1-0.30.2-0.20.1-0.51.00.50.3
Short access day 1 locomotion0.70.74.00.3-0.5-0.40.60.60.3-0.40.4-0.70.31.8-0.22.0
Short access day 10 total locomotion0.20.20.90.1-0.00.20.40.4-0.30.4-0.40.1-0.30.70.6-1.0
Short access total locomotion0.30.32.10.2-0.1-0.00.60.60.1-0.00.0-0.40.01.40.10.5
One hour access (0.3 mA shock)0.30.30.9-0.90.90.0-0.7-0.7-0.30.1-0.10.4-0.5-0.50.1-0.9
Compulsive drug intake1.11.14.2-0.30.4-0.2-1.3-1.3-0.70.6-0.61.1-0.8-2.10.5-1.6
One hour access (shock baseline)0.10.20.4-0.1-0.0-0.4-0.5-0.5-0.50.4-0.40.4-0.6-0.10.5-0.3
Social response proportion0.10.10.3-0.20.10.0-0.1-0.1-0.20.3-0.30.3-0.2-0.40.4-0.6
Social responses0.50.60.9-1.00.90.90.80.80.9-0.80.8-0.80.90.0-0.9-0.2
Social time1.41.97.50.1-0.5-0.2-0.9-0.9-1.31.5-1.51.5-1.3-1.51.6-2.7
Soleus weight0.61.84.9-0.80.60.31.21.21.1-1.31.3-1.51.22.1-1.22.2
Bone: stiffness0.81.23.2-0.60.81.71.81.60.9-0.50.5-0.90.90.2-0.5-1.6
Tibialis anterior weight5.719.425.9-4.64.84.45.15.04.5-4.54.5-4.74.35.0-3.50.4
Time to tail flick, vehicle, before self-admin0.40.41.80.7-0.30.10.20.2-0.50.8-0.80.5-0.4-0.30.6-1.3
Time to tail flick, vehicle, after self-admin5.86.29.02.2-2.2-2.7-2.4-2.4-2.93.0-3.02.7-2.9-1.32.8-0.4
Time to tail flick, test, before self-admin1.41.42.9-1.71.70.80.90.81.2-1.31.3-1.21.10.8-1.10.9
Time to tail flick, test, after self-admin1.61.62.61.5-1.6-1.5-1.4-1.4-1.31.3-1.31.1-1.3-0.90.90.5
Delta time to tail flick, vehicle, before/after SA6.76.69.92.0-2.4-3.1-3.1-3.0-2.92.7-2.62.7-2.8-1.62.60.6
Delta time to tail flick, test, before/after SA1.00.92.91.6-1.7-1.0-0.8-0.7-0.90.9-0.90.8-0.8-0.30.50.5
Tibia length0.10.20.50.7-0.5-0.10.30.3-0.30.5-0.60.2-0.30.10.4-0.2
Ambulatory time before self-admin2.93.04.2-1.51.41.91.91.92.0-1.91.9-2.02.01.1-2.00.1
Ambulatory time after self-admin2.02.24.0-1.11.41.61.41.41.7-1.71.7-1.71.80.2-2.00.4
Bone: tissue strength0.20.21.5-0.00.10.2-0.1-0.1-0.40.5-0.50.4-0.4-0.50.5-1.2
Total heroin consumption0.50.61.7-1.21.31.01.00.80.5-0.30.3-0.50.50.1-0.3-1.2
Bone: trabecular number2.13.34.71.4-1.0-1.9-2.1-2.1-2.12.0-2.02.1-2.2-0.92.1-0.6
Bone: trabecular spacing0.10.10.4-0.0-0.30.30.60.60.3-0.20.2-0.40.40.3-0.20.3
Bone: trabecular thickness0.60.72.10.7-0.4-0.7-1.3-1.3-0.60.5-0.50.8-0.6-1.40.2-0.2
Bone: trabecular tissue density1.62.33.9-0.80.92.01.91.91.7-1.41.4-1.71.9-0.0-1.8-0.4
Water consumed over 24 hours0.10.10.4-0.40.40.30.00.0-0.10.2-0.20.1-0.1-0.50.1-0.6
Number of responses in last shaping day1.41.52.8-0.90.81.11.61.61.2-1.21.2-1.41.21.7-1.10.5