Hub : Genes

Pde7a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Pde7a 0.03 0.02 5.3e-04 0.03 0.01 0.02 0.02 1.0e-04 2.9e-03 3.6e-04 7.0e-04
2 Adipose alternative TSS XM_039103227.2 0.03 0.02 1.9e-03 0.01 0 0.01 0.01 4.6e-02 7.4e-02 7.0e-02 5.5e-02
3 Adipose alternative TSS XM_039103227.2 0.03 0.02 6.5e-04 0.01 0.01 0.01 0.01 2.7e-02 3.2e-02 2.5e-02 1.6e-02
4 Adipose alternative polyA XM_006232188.5 0.02 0.02 8.2e-03 0.01 0.01 0 0 4.1e-02 5.8e-02 1.4e-01 9.7e-02
5 NAcc mRNA stability Pde7a 0.02 0.02 1.0e-03 0.02 0.01 0.01 0.01 6.7e-04 3.7e-03 2.3e-03 2.1e-03
6 PL gene expression Pde7a 0.08 0.07 3.0e-04 0.03 0.02 0.03 0.02 2.9e-04 3.6e-03 3.7e-04 2.2e-03
7 Brain gene expression Pde7a 0.07 0.04 1.8e-04 0.04 0.03 0.04 0.04 1.1e-04 9.4e-04 2.5e-04 1.2e-04
8 Adipose mRNA stability Pde7a 0.14 0.08 3.2e-13 0.08 0.08 0.08 0.07 4.7e-09 3.8e-09 6.6e-09 1.8e-08
9 Liver gene expression Pde7a 0.12 0.07 3.7e-12 0.07 0.07 0.07 0.08 3.0e-08 1.0e-08 1.1e-08 3.2e-09
10 Adipose isoform ratio XM_006232188.5 0.03 0.02 3.0e-03 0.01 0.01 0 0.01 1.1e-02 2.9e-02 8.0e-02 2.3e-02
11 Adipose alternative TSS XM_008760880.4 0.04 0.02 9.7e-04 0.01 0.01 0.01 0.01 2.8e-02 1.9e-02 6.7e-02 6.4e-02
12 Adipose gene expression Pde7a 0.1 0.05 4.8e-11 0.05 0.08 0.07 0.07 1.9e-06 3.9e-09 2.9e-08 1.9e-08
13 NAcc alternative TSS NM_031080.1 0.01 0.01 6.1e-03 0.01 0.01 0.01 0.01 2.0e-02 1.8e-02 3.2e-02 2.8e-02
14 Adipose alternative TSS XM_008760880.4 0.04 0.02 1.8e-03 0 0.01 0 0 9.1e-02 6.9e-02 1.3e-01 1.8e-01
15 NAcc alternative TSS XM_008760880.4 0.01 0.01 5.2e-03 0.01 0.01 0 0.01 1.6e-02 2.5e-02 5.7e-02 3.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.01.92.6-1.11.6-1.51.31.3-1.3-1.61.51.31.51.51.3-1.11.4-0.9
Area under the delay curve0.10.20.60.8-0.80.7-0.5-0.50.50.2-0.3-0.40.2-0.1-0.30.4-0.10.3
BMI with tail2.06.810.23.1-3.23.0-2.9-2.92.93.2-2.7-2.5-2.0-2.4-2.22.0-2.21.4
BMI without tail1.26.27.82.8-2.72.7-2.6-2.62.62.8-2.6-2.6-2.2-2.3-2.42.4-2.11.8
Body weight2.29.514.02.9-3.63.5-2.9-2.92.93.7-3.2-3.1-2.8-3.3-2.92.5-3.22.1
Weight adjusted by age0.20.51.30.3-0.80.8-0.1-0.10.10.7-0.8-0.7-0.8-1.0-0.80.7-1.10.8
Bone surface0.00.00.10.00.1-0.20.10.1-0.1-0.20.20.20.30.30.3-0.20.3-0.2
Bone volume0.00.00.0-0.00.1-0.10.10.1-0.1-0.10.10.10.10.10.1-0.00.20.0
Breakpoint value in progressive ratio session0.10.20.60.8-0.30.4-0.4-0.40.40.2-0.6-0.6-0.6-0.3-0.60.7-0.00.5
Number of licking bursts0.61.72.51.0-1.51.5-0.8-0.80.81.5-1.5-1.3-1.5-1.6-1.41.2-1.61.2
Context. condit. distance diff. score0.20.31.0-0.1-0.60.6-0.0-0.00.00.6-0.4-0.5-0.2-0.8-0.50.3-1.00.6
Locomotion velocity, session 10.40.40.90.7-0.60.6-1.0-1.01.00.5-0.5-0.7-0.2-0.4-0.50.6-0.30.5
Locomotion distance, session 10.20.30.90.4-0.0-0.1-0.3-0.30.3-0.10.40.40.70.70.7-0.70.8-1.0
Locomotion velocity, session 22.22.75.52.1-1.71.7-2.3-2.32.31.6-1.4-1.6-0.9-1.0-1.21.3-0.70.9
Locomotion distance, session 20.20.31.30.20.1-0.2-0.1-0.10.1-0.10.50.60.80.70.8-0.90.7-1.1
Locomotion velocity, session 31.01.21.91.2-1.41.3-1.2-1.21.21.3-1.1-1.1-0.7-1.0-0.90.9-0.90.7
Locomotion distance, session 30.80.91.31.1-1.11.1-0.9-0.90.91.2-1.0-1.0-0.5-0.9-1.01.0-0.90.9
Stereotopy head waving bouts, day 30.30.30.8-0.90.6-0.60.90.9-0.9-0.50.50.50.20.20.3-0.40.1-0.2
Stereotopy head waving duration, day 30.50.71.0-1.01.0-1.00.90.9-0.9-1.00.70.90.20.70.7-0.70.7-0.6
Locomotion velocity, session 72.93.24.4-2.11.9-1.92.02.0-2.0-1.71.81.91.51.41.8-1.91.1-1.6
Locomotion distance, session 72.63.35.1-2.32.2-2.22.12.1-2.1-2.01.81.81.31.41.6-1.61.1-1.2
Stereotopy head waving bouts, day 70.70.81.50.9-1.21.2-0.7-0.70.71.0-0.9-0.9-0.6-0.9-0.90.8-0.90.7
Stereotopy head waving duration, day 70.40.50.80.8-0.90.9-0.5-0.50.50.7-0.8-0.7-0.6-0.6-0.80.8-0.50.7
Locomotion velocity, session 81.11.32.81.3-1.31.3-1.7-1.71.71.3-1.0-1.1-0.4-0.8-0.80.7-0.70.5
Locomotion distance, session 80.91.42.31.2-1.51.4-1.3-1.31.31.5-1.1-1.2-0.6-1.1-0.90.7-1.10.5
Degree of sensitization distance4.75.07.3-2.42.7-2.72.22.2-2.2-2.62.32.41.52.12.2-2.12.0-1.8
Degree of sensitization stereotypy2.42.74.31.7-2.12.0-1.5-1.51.51.9-1.7-1.8-1.1-1.6-1.61.6-1.61.4
Conditioned locomotion2.12.53.6-1.31.5-1.51.31.3-1.3-1.61.81.61.91.71.8-1.71.5-1.6
Cocaine response after cond. corrected0.10.10.3-0.50.4-0.30.10.1-0.1-0.4-0.0-0.1-0.5-0.2-0.30.3-0.20.5
Cocaine response after cond. not corrected0.10.10.4-0.50.3-0.20.10.1-0.1-0.4-0.1-0.1-0.6-0.2-0.30.3-0.30.5
Cocaine response before conditioning0.30.40.6-0.50.5-0.60.50.5-0.5-0.50.60.70.60.60.7-0.80.6-0.8
Saline control response0.30.40.90.7-0.90.9-0.6-0.60.60.9-0.7-0.5-0.7-0.6-0.40.3-0.50.1
Bone: connectivity density1.62.54.8-0.81.9-1.91.11.1-1.1-1.91.71.41.82.11.6-1.22.2-1.1
Bone: cortical apparent density0.91.42.01.3-1.11.2-1.3-1.31.31.0-1.2-1.4-0.8-1.0-1.31.4-0.91.4
Bone: cortical area0.40.72.9-0.4-1.11.10.20.2-0.21.1-0.6-0.5-0.9-1.3-0.60.1-1.70.3
Bone: cortical porosity1.21.32.3-1.10.9-1.11.11.1-1.1-0.81.21.30.91.01.3-1.50.9-1.5
Bone: cortical porosity0.70.71.5-0.90.6-0.70.80.8-0.8-0.40.91.00.80.61.0-1.20.5-1.2
Bone: cortical thickness0.60.93.0-1.70.1-0.21.51.5-1.5-0.10.70.80.6-0.20.7-1.1-0.8-0.7
Bone: cortical thickness0.10.20.60.1-0.70.6-0.3-0.30.30.8-0.3-0.3-0.1-0.5-0.1-0.1-0.6-0.1
Bone: cortical tissue density1.21.82.61.5-1.21.3-1.5-1.51.51.1-1.3-1.6-0.9-1.1-1.41.6-1.01.5
Condit. Reinf. active minus inactive responses0.10.10.60.4-0.20.1-0.1-0.10.10.00.20.40.20.40.5-0.60.5-0.8
Condit. Reinf. active-inactive response ratio0.10.10.40.10.1-0.20.10.1-0.1-0.30.30.40.20.50.4-0.40.6-0.6
Condit. Reinf. active responses0.10.10.60.8-0.50.4-0.4-0.40.40.3-0.0-0.00.20.20.2-0.20.4-0.4
Condit. Reinf. inactive responses0.40.61.11.1-0.90.9-1.0-1.01.00.8-0.7-0.7-0.4-0.5-0.50.6-0.30.3
Incentive salience index mean0.10.10.60.8-0.60.5-0.4-0.40.40.4-0.3-0.2-0.3-0.1-0.10.10.0-0.1
Condit. Reinf. lever presses0.50.81.81.3-0.90.9-0.9-0.90.90.7-0.9-1.0-0.8-0.6-0.91.1-0.30.9
Condit. Reinf. active minus inactive responses0.00.00.1-0.1-0.30.20.10.1-0.10.40.00.00.3-0.20.1-0.3-0.3-0.3
Condit. Reinf. active-inactive response ratio0.00.00.40.1-0.10.1-0.1-0.10.10.20.1-0.10.60.00.1-0.1-0.1-0.1
Condit. Reinf. active responses0.10.20.5-0.5-0.0-0.10.50.5-0.50.10.30.50.20.00.5-0.7-0.1-0.7
Condit. Reinf. inactive responses0.10.10.4-0.6-0.20.20.50.5-0.50.2-0.00.3-0.6-0.40.1-0.4-0.5-0.3
Condit. Reinf. lever presses0.30.40.9-0.80.7-0.70.90.9-0.9-0.40.40.70.00.30.4-0.50.2-0.5
Condit. Reinf. lever reinforcers received0.10.20.5-0.4-0.1-0.00.40.4-0.40.10.30.40.20.00.4-0.7-0.1-0.7
Conditioned reinforcement - actives0.10.40.6-0.40.6-0.60.50.5-0.5-0.60.70.70.60.70.7-0.70.8-0.7
Conditioned reinforcement - inactives0.00.10.50.20.2-0.10.00.0-0.0-0.2-0.2-0.2-0.40.0-0.30.50.20.7
Conditioned locomotion0.20.30.70.5-0.40.6-0.2-0.20.20.3-0.6-0.7-0.5-0.5-0.70.8-0.40.8
Patch foraging indifference point 0 sec0.30.92.10.4-0.80.9-0.2-0.20.20.6-1.0-1.1-1.0-1.1-1.21.3-1.21.5
Patch foraging indifference point AUC0.20.61.7-0.00.5-0.6-0.2-0.20.2-0.40.80.61.31.01.0-0.91.0-1.0
Delay disc. indifference point, 0s delay0.10.10.2-0.3-0.40.30.10.1-0.10.40.10.10.3-0.20.2-0.4-0.4-0.4
Delay disc. indifference point, 16s delay0.30.41.10.10.4-0.50.30.3-0.3-0.70.70.61.10.80.7-0.60.8-0.6
Delay disc. indifference point, 2s delay0.20.20.60.1-0.80.8-0.2-0.20.20.3-0.4-0.6-0.2-0.5-0.50.6-0.60.6
Delay disc. indifference point, 24s delay0.71.01.6-0.90.7-0.71.11.1-1.1-1.21.21.11.31.11.0-0.91.0-0.7
Delay disc. indifference point, 4s delay2.22.34.42.1-2.01.9-1.9-1.91.91.4-1.4-1.4-0.7-0.9-1.21.3-0.60.8
Delay disc. indifference point, 8s delay0.20.31.11.0-0.60.6-0.6-0.60.60.2-0.3-0.5-0.1-0.1-0.40.50.00.4
Indifference point function ln k0.61.93.81.3-0.91.0-1.1-1.11.11.0-1.6-1.6-1.7-1.2-1.72.0-1.01.9
Indifference point function log k0.61.93.81.3-0.91.0-1.1-1.11.11.0-1.6-1.6-1.7-1.2-1.72.0-1.01.9
Patch foraging total patch changes 0 sec0.51.53.20.8-1.11.2-0.5-0.50.50.9-1.3-1.4-1.3-1.4-1.61.6-1.41.8
Patch foraging total patch changes 12 sec0.00.00.2-0.2-0.10.10.10.1-0.1-0.10.2-0.10.40.00.2-0.3-0.1-0.2
Patch foraging total patch changes 18 sec0.00.10.20.4-0.40.3-0.3-0.30.30.30.0-0.20.4-0.00.1-0.2-0.1-0.2
Patch foraging total patch changes 24 sec0.00.20.50.00.4-0.4-0.1-0.10.1-0.50.50.20.70.60.4-0.30.7-0.3
Patch foraging total patch changes 6 sec0.50.91.51.2-0.91.0-1.0-1.01.01.0-0.9-1.1-0.6-0.7-0.91.0-0.50.8
Patch foraging time to switch 0 sec0.00.00.0-0.1-0.00.00.10.1-0.10.00.00.1-0.2-0.00.1-0.2-0.0-0.2
Patch foraging water rate 0 sec0.10.51.00.9-0.50.6-0.9-0.90.90.5-0.6-0.8-0.2-0.4-0.81.0-0.31.0
Patch foraging water rate 12 sec0.20.71.1-0.60.8-0.80.70.7-0.7-0.60.91.00.80.90.9-0.90.8-1.0
Patch foraging water rate 18 sec0.10.10.2-0.30.4-0.40.30.3-0.3-0.40.40.40.30.40.3-0.30.4-0.3
Patch foraging water rate 24 sec0.20.20.8-0.10.5-0.50.10.1-0.1-0.60.60.50.90.70.5-0.30.7-0.3
Patch foraging water rate 6 sec0.81.22.30.7-0.80.9-0.7-0.70.70.9-1.2-1.0-1.3-1.2-1.41.5-1.11.5
Seeking ratio, delayed vs. immediate footshock1.92.85.1-2.32.2-2.01.91.9-1.9-2.11.71.41.31.31.2-1.11.0-0.4
Distance traveled before self-admin2.96.48.92.5-3.02.9-2.5-2.52.53.0-2.7-2.6-2.4-2.6-2.42.1-2.51.7
Distance traveled after self-admin5.49.512.42.7-3.33.3-2.7-2.72.73.2-3.4-3.2-3.5-3.3-3.23.1-3.12.7
Extensor digitorum longus weight5.823.231.55.6-5.35.2-5.5-5.55.55.3-4.9-5.0-3.8-4.1-4.34.2-3.63.3
Bone: elastic displacement1.82.34.1-1.51.6-1.61.61.6-1.6-1.41.71.52.01.51.5-1.41.2-1.1
Bone: elastic work0.40.60.9-0.90.9-0.80.90.9-0.9-0.70.80.60.90.60.6-0.50.5-0.2
Bone: endosteal estimation1.12.73.81.9-1.91.8-2.0-2.02.01.9-1.7-1.5-1.7-1.4-1.31.1-1.10.6
Bone: endosteal perimeter1.53.66.11.1-2.12.1-1.3-1.31.32.0-2.1-1.9-2.5-2.4-2.01.7-2.41.6
Epididymis fat weight1.57.79.22.3-3.03.0-2.7-2.72.73.0-2.9-2.9-2.7-3.0-2.72.5-3.02.2
Delta time in closed arm before/after self-admin0.50.50.9-0.20.5-0.60.40.4-0.4-0.60.70.70.80.90.8-0.80.9-0.9
Delta time in open arm before/after self-admin0.10.20.7-0.4-0.10.10.10.1-0.10.1-0.2-0.2-0.4-0.6-0.40.3-0.80.6
Diff in mean of infusions in LGA sessions0.10.20.4-0.20.5-0.50.40.4-0.4-0.60.40.40.40.60.4-0.30.6-0.3
Delay discount exponential model param0.20.20.6-0.70.8-0.80.50.5-0.5-0.20.30.4-0.00.20.3-0.40.1-0.3
Extinction: sum of active levers before priming0.00.10.2-0.30.4-0.40.30.3-0.3-0.40.30.20.20.20.2-0.20.2-0.1
Active lever presses in extinction session 60.60.61.40.7-1.21.0-0.8-0.80.81.1-0.8-0.4-0.9-0.8-0.30.0-0.7-0.4
Bone: final force0.60.92.30.8-1.51.4-0.8-0.80.81.4-0.9-0.7-1.0-1.1-0.60.2-1.2-0.0
Bone: final moment0.50.82.10.6-1.51.3-0.7-0.70.71.3-0.9-0.6-1.0-1.1-0.50.1-1.2-0.1
Food consumed during 24 hour testing period2.34.76.32.5-2.42.4-2.3-2.32.32.5-2.3-2.2-2.1-1.9-2.01.9-1.61.4
Glucose0.30.41.20.6-1.00.9-0.4-0.40.41.1-0.7-0.4-0.6-0.7-0.40.2-0.7-0.0
Heart weight0.61.01.51.2-1.01.0-1.0-1.01.00.9-1.0-1.1-0.8-0.8-1.11.2-0.61.1
Delay discount hyperbolic model param0.30.31.0-0.81.0-0.90.60.6-0.6-0.40.40.50.10.30.4-0.50.3-0.4
Intermittent access intake day 1-15 change0.00.20.80.8-0.40.3-0.9-0.90.90.6-0.2-0.20.20.20.10.00.4-0.2
Intermittent access intake escalation0.00.30.80.8-0.40.4-0.9-0.90.90.6-0.2-0.30.10.1-0.00.10.3-0.1
Intermittent access intake escalation 20.10.20.50.6-0.40.3-0.7-0.70.70.5-0.2-0.2-0.00.0-0.00.00.2-0.2
Intermitt. access day 1 inactive lever presses0.00.41.21.1-0.60.5-1.1-1.11.10.5-0.5-0.4-0.70.0-0.20.30.30.0
Intermitt. access day 15 inactive lever presses0.10.62.10.10.6-0.7-0.1-0.10.1-0.60.70.70.71.20.9-0.81.4-1.0
Intermitt. access escalation Index0.10.31.0-0.50.9-0.80.50.5-0.5-1.00.40.5-0.50.60.3-0.10.8-0.1
Intermittent access day 1 total infusions0.10.21.00.20.3-0.4-0.0-0.00.0-0.40.50.30.60.80.5-0.41.0-0.6
Intermittent access day 15 total infusions0.40.93.10.30.5-0.6-0.2-0.20.2-0.50.90.71.31.51.2-1.01.8-1.3
Intermittent access terminal intake (last 3 days)0.50.92.91.1-0.0-0.1-0.9-0.90.90.10.50.31.11.30.9-0.81.7-1.3
Intermittent access total infusions1.01.24.30.40.7-0.8-0.2-0.20.2-0.71.00.81.41.81.3-1.02.1-1.4
Intermittent access day 1 locomotion0.00.10.10.4-0.40.4-0.3-0.30.30.3-0.1-0.30.4-0.1-0.10.1-0.2-0.0
Intermittent access day 15 total locomotion0.10.30.50.7-0.60.6-0.6-0.60.60.6-0.5-0.7-0.2-0.4-0.50.5-0.30.4
Intermittent access total locomotion0.10.20.30.6-0.50.5-0.5-0.50.50.5-0.4-0.6-0.0-0.2-0.40.4-0.20.3
Intermittent access standard deviation0.10.30.90.9-0.50.4-0.9-0.90.90.6-0.2-0.20.00.20.1-0.00.4-0.3
Left kidney weight0.21.42.20.8-1.11.2-0.6-0.60.61.2-1.3-1.3-1.0-1.4-1.41.4-1.51.5
Right kidney weight0.43.05.41.2-1.91.9-1.0-1.01.02.0-1.9-1.8-1.6-2.2-1.91.7-2.31.6
Cocaine induced anxiety0.10.20.4-0.40.0-0.10.50.5-0.5-0.00.30.50.40.20.5-0.70.0-0.7
Post-drug Anxiety0.50.61.6-0.60.5-0.60.50.5-0.5-0.50.81.00.70.71.0-1.20.6-1.3
Baseline Anxiety0.10.20.40.6-0.20.2-0.6-0.60.60.2-0.4-0.4-0.4-0.1-0.40.50.10.3
Tail length0.31.42.50.6-1.01.1-0.6-0.60.61.1-1.3-1.3-1.5-1.5-1.41.3-1.61.4
Length with tail0.73.05.01.1-1.91.9-1.1-1.11.12.0-1.9-1.8-2.1-2.2-1.81.5-2.21.5
Length without tail0.52.44.31.1-1.91.9-1.2-1.21.22.1-1.6-1.6-1.4-1.9-1.41.1-2.01.0
Times rat made contact with spout3.84.47.71.2-2.22.3-1.3-1.31.32.3-2.3-2.1-2.8-2.6-2.31.9-2.71.9
Lifetime Intake0.91.13.80.30.6-0.7-0.2-0.20.2-0.71.00.71.41.71.3-1.02.0-1.3
Liver weight, left0.50.92.21.1-1.51.3-0.8-0.80.81.3-1.0-0.6-0.9-0.9-0.60.4-0.80.0
Liver weight, right4.27.39.42.6-2.82.8-2.8-2.82.82.8-2.9-2.8-3.1-2.6-2.62.4-2.32.0
Locomotor activity0.40.61.20.8-1.11.0-0.7-0.70.71.0-0.9-0.7-0.8-0.8-0.70.5-0.80.3
Locomotor testing distance0.40.91.80.6-1.41.3-0.7-0.70.71.3-1.0-0.7-1.0-1.2-0.80.5-1.20.3
Locomotor testing rearing0.10.20.8-0.80.1-0.20.50.5-0.5-0.20.40.6-0.1-0.00.5-0.8-0.2-0.9
Locomotion in novel chamber0.20.30.70.1-0.80.8-0.2-0.20.20.7-0.5-0.3-0.4-0.7-0.40.3-0.80.3
Locomotion in novel chamber post-restriction0.41.22.0-0.51.2-1.20.60.6-0.6-1.01.11.21.21.31.2-1.21.4-1.3
Fecal boli incidents, locomotor time 10.41.14.20.00.6-0.90.20.2-0.2-0.61.01.20.81.21.4-1.61.4-2.0
Change in fecal boli incidents, locomotor task1.11.24.1-2.00.9-0.81.71.7-1.7-0.80.80.70.5-0.00.4-0.6-0.50.3
Time >=10cm from walls, locomotor time 10.30.40.6-0.70.8-0.80.70.7-0.7-0.60.60.50.20.50.6-0.70.3-0.5
Bouts of movement, locomotor time 10.30.41.00.10.8-0.8-0.1-0.10.1-0.70.60.21.00.90.5-0.21.0-0.3
Total resting periods, locomotor time 10.40.41.20.20.9-0.8-0.0-0.00.0-0.70.60.21.11.00.5-0.21.1-0.2
Rest time, locomotor task time 10.40.62.01.4-0.0-0.1-1.1-1.11.10.20.10.00.60.80.6-0.61.1-1.1
Distance moved, locomotor task time 10.41.12.8-1.1-0.30.50.70.7-0.70.2-0.8-0.6-1.7-1.4-1.21.0-1.61.5
Vertical activity count, locomotor time 10.32.15.5-0.2-1.11.3-0.0-0.00.00.7-1.4-1.3-2.3-1.9-1.81.8-1.92.1
Time >=10cm from walls, locomotor time 20.30.91.8-1.10.6-0.71.31.3-1.3-0.71.00.90.60.51.0-1.30.2-0.7
Bouts of movement, locomotor time 20.10.31.20.60.3-0.3-0.2-0.20.2-0.50.50.21.10.80.4-0.10.9-0.3
Total resting periods, locomotor time 20.10.31.20.80.2-0.3-0.4-0.40.4-0.40.40.01.10.80.3-0.00.9-0.3
Rest time, locomotor task time 20.61.03.31.10.4-0.6-0.7-0.70.7-0.50.60.61.21.41.0-0.81.8-1.4
Distance moved, locomotor task time 20.40.52.0-1.40.3-0.21.11.1-1.1-0.40.10.3-0.8-0.4-0.20.0-0.70.4
Vertical activity count, locomotor time 20.61.44.00.9-1.01.0-0.9-0.90.90.8-1.3-1.1-2.0-1.2-1.41.4-1.01.1
Light reinforcement 10.31.31.70.8-1.31.3-1.1-1.11.11.2-1.1-1.2-1.0-1.3-1.11.0-1.31.0
Light reinforcement 23.17.011.71.1-2.32.5-1.6-1.61.62.3-2.8-2.8-3.1-3.3-3.23.0-3.43.4
Bone: marrow area1.12.74.02.0-1.91.8-2.0-2.02.01.9-1.7-1.5-1.7-1.4-1.31.1-1.00.6
Bone: maximum diameter0.71.43.90.1-1.51.4-0.4-0.40.41.4-1.2-1.0-1.6-1.7-1.10.7-2.00.8
Bone: maximum force0.61.22.51.0-1.61.4-1.1-1.11.11.5-1.1-0.8-1.2-1.1-0.60.3-1.0-0.1
Bone: maximum moment0.50.92.20.9-1.51.3-0.9-0.90.91.4-0.9-0.6-1.1-1.0-0.50.1-1.0-0.2
Mean time between licks in bursts0.10.82.01.4-0.50.5-1.4-1.41.40.5-0.8-0.8-0.7-0.2-0.60.80.20.4
Mean num. licks in bursts0.00.00.2-0.40.2-0.20.20.2-0.2-0.10.20.2-0.10.00.2-0.3-0.0-0.3
Cd content in liver0.70.82.11.4-1.11.0-1.3-1.31.31.1-0.7-0.6-0.3-0.3-0.20.1-0.1-0.4
Co content in liver1.01.23.30.6-1.11.1-0.9-0.90.91.2-1.2-0.9-1.8-1.4-1.10.9-1.30.8
Cu content in liver0.20.30.7-0.80.5-0.50.80.8-0.8-0.50.40.50.10.10.3-0.4-0.0-0.3
Fe content in liver0.30.30.9-1.00.2-0.30.70.7-0.7-0.20.40.60.2-0.00.5-0.8-0.2-0.8
K content in liver0.60.61.1-1.01.0-0.90.90.9-0.9-1.00.70.70.30.50.4-0.40.5-0.1
Mg content in liver0.30.40.8-0.70.9-0.80.80.8-0.8-0.90.50.50.40.50.3-0.10.40.1
Mn content in liver0.00.00.10.3-0.00.0-0.2-0.20.20.0-0.1-0.10.10.1-0.10.20.10.2
Na content in liver0.60.71.70.1-0.80.9-0.2-0.20.20.8-0.9-0.8-0.8-1.2-1.01.0-1.31.1
Rb content in liver1.61.93.0-1.71.2-1.31.61.6-1.6-1.21.41.61.00.91.4-1.70.6-1.6
Se content in liver0.10.10.4-0.60.1-0.20.50.5-0.5-0.10.30.40.1-0.10.3-0.4-0.3-0.3
Sr content in liver1.00.82.3-0.41.1-1.00.70.7-0.7-1.10.90.80.81.30.8-0.51.5-0.4
Zn content in liver0.10.10.3-0.20.6-0.50.40.4-0.4-0.50.20.1-0.10.30.00.10.40.2
Bone: minimum diameter0.51.02.20.5-1.21.2-0.5-0.50.51.0-1.1-0.9-1.5-1.3-1.00.8-1.40.8
Time in familiar zone, hab. session 10.10.10.3-0.30.3-0.30.50.5-0.5-0.50.10.4-0.50.20.1-0.10.4-0.2
Time in novel zone, hab. session 10.30.30.50.6-0.60.6-0.6-0.60.60.6-0.5-0.70.1-0.5-0.50.5-0.60.5
Total zone transitions, hab. session 10.00.10.40.3-0.10.1-0.4-0.40.4-0.00.2-0.20.60.20.1-0.00.20.0
Total locomotion distance, hab. session 10.00.00.4-0.0-0.20.1-0.1-0.10.10.10.1-0.10.60.10.1-0.1-0.00.0
Locomotion velocity, hab. session 10.10.10.10.2-0.40.4-0.3-0.30.30.3-0.1-0.30.4-0.2-0.20.3-0.20.3
Time in familiar zone, hab. session 20.20.30.6-0.80.8-0.70.60.6-0.6-0.70.30.5-0.30.30.2-0.10.3-0.0
Time in novel zone, hab. session 20.30.41.1-0.00.3-0.40.30.3-0.3-0.40.70.61.00.80.8-0.80.8-0.9
Total zone transitions, hab. session 20.20.30.60.6-0.70.7-0.5-0.50.50.7-0.5-0.6-0.1-0.5-0.40.4-0.50.4
Total locomotion distance, hab. session 20.00.00.10.0-0.20.20.10.1-0.10.10.10.00.3-0.00.1-0.1-0.1-0.1
Locomotion velocity, hab. session 20.00.10.20.1-0.40.40.00.0-0.00.2-0.1-0.20.2-0.2-0.20.2-0.30.3
Novel to familiar place preference ratio1.82.43.9-1.31.5-1.51.21.2-1.2-1.51.71.62.01.61.7-1.71.5-1.5
Novelty place preference1.62.03.4-1.21.4-1.41.21.2-1.2-1.51.61.41.91.51.5-1.51.4-1.3
Time in novel zone, NPP test1.41.72.7-1.01.2-1.31.11.1-1.1-1.31.41.31.61.41.4-1.41.2-1.2
Total zone transitions, NPP test0.10.20.60.1-0.0-0.10.10.1-0.1-0.10.40.40.70.50.6-0.60.5-0.7
Total locomotion distance, NPP test0.00.10.2-0.2-0.10.00.20.2-0.2-0.00.30.30.40.20.3-0.40.1-0.4
Locomotion velocity, NPP test0.30.50.9-0.60.5-0.50.50.5-0.5-0.60.80.70.90.70.8-0.90.6-0.8
Intraocular pressure0.60.92.21.3-1.01.0-1.5-1.51.51.0-0.8-1.0-0.4-0.5-0.60.7-0.40.4
Delta distance traveled before/after self-admin0.10.10.3-0.0-0.10.1-0.0-0.00.0-0.0-0.2-0.3-0.3-0.3-0.40.4-0.30.5
Delta ambulatory time before/after self-admin0.10.20.4-0.60.5-0.50.60.6-0.6-0.60.30.30.20.1-0.00.10.00.5
Parametrial fat weight3.27.610.02.3-3.23.1-2.6-2.62.63.1-2.9-2.8-2.8-3.0-2.72.4-3.02.1
Pavlov. Cond. lever latency0.30.41.5-1.20.6-0.60.80.8-0.8-0.20.60.60.70.10.6-0.7-0.2-0.5
Pavlov. Cond. magazine entry latency0.60.72.91.7-0.50.5-1.1-1.11.10.3-0.8-0.8-0.60.0-0.71.10.50.7
Pavlov. Cond. change in total contacts2.62.95.92.4-1.81.8-2.0-2.02.01.5-1.7-1.7-1.5-1.1-1.51.7-0.71.2
Pavlov. Cond. index score1.51.95.32.3-1.31.3-1.7-1.71.70.9-1.4-1.4-1.2-0.6-1.31.6-0.11.2
Pavlov. Cond. latency score0.91.13.71.9-1.01.0-1.3-1.31.30.7-1.0-1.0-0.9-0.3-0.91.10.10.7
Pavlov. Cond. lever contacts0.81.03.11.7-0.70.8-1.2-1.21.20.4-0.9-1.1-0.8-0.3-0.91.30.21.0
Pavlov. Cond. magazine entry number1.92.45.8-2.41.3-1.31.81.8-1.8-1.01.61.71.40.71.5-1.90.2-1.5
Pavlov. Cond. intertrial magazine entries0.30.30.9-0.80.5-0.50.60.6-0.6-0.50.70.51.00.30.5-0.50.1-0.3
Pavlov. Cond. lever-magazine prob. diff.2.22.86.52.5-1.51.5-1.9-1.91.91.2-1.7-1.8-1.5-0.9-1.61.9-0.31.5
Pavlov. Cond. response bias2.22.76.42.5-1.31.4-2.0-2.02.01.0-1.7-1.8-1.4-0.8-1.72.1-0.21.7
Pavlov. Cond. lever latency0.30.41.31.1-0.10.1-1.1-1.11.1-0.10.0-0.30.60.60.10.20.9-0.1
Pavlov. Cond. magazine entry latency0.20.30.70.4-0.30.4-0.3-0.30.30.5-0.6-0.5-0.8-0.5-0.60.7-0.40.6
Pavlov. Cond. change in total contacts0.10.31.0-1.00.1-0.20.90.9-0.9-0.00.30.50.0-0.20.3-0.6-0.5-0.4
Pavlov. Cond. index score0.20.30.9-0.2-0.40.50.10.1-0.10.6-0.6-0.3-0.9-0.9-0.60.5-1.00.6
Pavlov. Cond. latency score0.20.30.8-0.2-0.40.40.10.1-0.10.5-0.5-0.3-0.9-0.8-0.50.4-0.90.5
Pavlov. Cond. lever contacts0.30.51.3-1.20.1-0.11.11.1-1.10.1-0.10.3-0.6-0.7-0.2-0.1-1.00.2
Pavlov. Cond. magazine entry number0.10.10.50.10.3-0.30.10.1-0.1-0.40.40.20.70.50.4-0.20.6-0.3
Pavlov. Cond. intertrial magazine entries0.20.40.8-0.40.7-0.70.40.4-0.4-0.80.70.60.90.80.7-0.60.8-0.6
Pavlov. Cond. lever-magazine prob. diff.0.30.41.1-0.0-0.60.6-0.1-0.10.10.7-0.7-0.5-1.0-1.0-0.80.6-1.10.7
Pavlov. Cond. response bias0.20.30.9-0.7-0.10.20.80.8-0.80.3-0.30.0-0.8-0.8-0.30.1-1.00.3
Time in closed arm before self-admin0.10.10.50.50.00.1-0.2-0.20.2-0.1-0.3-0.4-0.2-0.0-0.40.70.20.7
Time in closed arm after self-admin0.10.10.50.10.5-0.40.20.2-0.2-0.60.10.1-0.30.4-0.00.20.70.2
Time in open arm before self-admin0.30.40.60.3-0.70.7-0.6-0.60.60.7-0.6-0.5-0.8-0.7-0.50.3-0.70.2
Time in open arm after self-admin0.91.02.40.3-1.11.1-0.8-0.80.81.2-1.0-1.0-0.9-1.4-1.00.7-1.60.8
Bone: periosteal estimation0.82.03.40.9-1.91.8-1.1-1.11.11.8-1.5-1.2-1.8-1.7-1.20.8-1.80.7
Bone: periosteal perimeter1.12.15.80.1-1.71.7-0.4-0.40.41.6-1.5-1.3-1.9-2.1-1.41.0-2.41.2
Bone: post-yield work0.71.12.31.4-1.11.0-1.5-1.51.51.3-1.1-0.7-1.3-0.6-0.60.4-0.3-0.2
Progressive ratio test 1 active lever presses0.20.30.80.9-0.60.5-0.7-0.70.70.5-0.1-0.20.60.20.2-0.20.3-0.5
Progressive ratio test 1 breakpoint0.20.30.80.9-0.60.5-0.7-0.70.70.5-0.0-0.20.60.30.3-0.20.4-0.5
Progressive ratio test 1 inactive lever presses0.30.81.4-0.51.0-0.90.60.6-0.6-1.01.00.90.91.10.9-0.81.2-0.6
Progressive ratio test 2 active lever presses0.20.21.30.20.2-0.2-0.0-0.00.0-0.20.50.21.20.70.5-0.40.8-0.4
Progressive ratio test 2 breakpoint0.10.20.90.30.1-0.1-0.1-0.10.1-0.10.30.11.00.60.4-0.20.7-0.2
Progressive ratio test 2 inactive lever presses0.20.52.10.30.4-0.5-0.2-0.20.2-0.40.70.60.81.20.9-0.71.5-1.0
Incentive Sensitization - Responses0.10.20.80.00.5-0.50.10.1-0.1-0.50.40.20.60.70.4-0.10.9-0.1
Incentive Sensitization - Breakpoint0.10.10.60.10.4-0.4-0.0-0.00.0-0.40.30.10.40.60.20.00.80.1
Sum of active levers in priming session hrs 5-60.60.60.90.7-0.80.8-0.8-0.80.80.7-0.8-0.9-1.0-0.8-0.80.7-0.80.6
Progressive ratio0.30.91.6-0.61.0-1.10.70.7-0.7-0.91.01.10.71.01.2-1.30.9-1.2
Food seeking constrained by brief footshock0.20.30.7-0.30.9-0.80.20.2-0.2-0.80.40.50.20.70.4-0.20.8-0.2
Seeking ratio, punishment vs. effort0.10.31.10.2-0.30.4-0.3-0.30.30.2-0.5-0.6-0.4-0.4-0.81.0-0.41.0
Retroperitoneal fat weight1.04.66.12.4-2.52.4-2.5-2.52.52.3-2.1-2.2-1.5-1.9-1.91.9-1.71.5
Reaction time number correct0.51.83.9-2.01.2-1.21.81.8-1.8-1.21.31.50.70.71.2-1.40.4-1.1
Reaction time mean minus median1.27.713.33.6-2.52.5-3.6-3.63.62.5-2.8-2.9-2.3-1.8-2.52.8-1.22.2
Reaction time mean minus median AUC1.06.912.93.6-2.32.3-3.5-3.53.52.4-2.6-2.6-2.0-1.6-2.32.5-1.01.8
Reaction time num false alarms2.54.36.9-2.51.7-1.82.62.6-2.6-1.72.12.31.61.42.1-2.40.9-2.0
Reaction time num false alarms AUC1.53.56.4-2.51.5-1.52.52.5-2.5-1.51.82.01.31.11.8-2.10.6-1.6
Reaction time trials correct on left0.51.83.9-2.01.2-1.21.81.8-1.8-1.21.31.50.70.71.2-1.40.4-1.1
Reaction time trials on left0.51.83.8-1.91.1-1.21.81.8-1.8-1.11.21.50.60.71.2-1.40.3-1.1
Reaction time mean0.71.53.81.6-0.90.9-2.0-2.02.01.0-1.1-1.1-1.1-0.6-0.90.9-0.20.5
Reaction time mean AUC0.41.12.91.4-0.70.7-1.7-1.71.70.7-0.9-0.8-1.0-0.4-0.70.8-0.00.4
Median of all reaction times0.20.31.10.6-0.20.2-1.1-1.11.10.3-0.3-0.2-0.5-0.0-0.10.10.2-0.2
Reaction time omissions0.40.71.21.1-1.00.9-1.0-1.01.00.9-0.9-0.6-0.9-0.6-0.60.4-0.50.1
Reaction time false alarm rate0.71.02.0-1.30.7-0.71.41.4-1.4-0.70.91.00.80.50.9-1.10.2-0.8
Reaction time premature initiation rate0.10.20.80.30.5-0.4-0.2-0.20.2-0.70.40.10.70.70.3-0.00.90.0
Reaction time premature initiations0.20.51.0-0.40.8-0.80.40.4-0.4-1.00.80.60.80.90.6-0.50.9-0.3
Std. dev. reaction times1.34.48.12.7-1.91.9-2.8-2.82.82.0-2.1-2.0-1.9-1.4-1.81.9-0.91.3
Reaction time trials completed0.51.83.8-1.91.1-1.21.81.8-1.8-1.11.21.50.60.71.2-1.40.3-1.1
Reaction time trials AUC0.41.43.2-1.81.0-1.01.61.6-1.6-1.01.11.40.50.51.1-1.30.2-1.0
Run reversals in cocaine runway, females5.36.07.22.2-2.52.6-2.0-2.02.02.3-2.7-2.6-2.7-2.6-2.72.7-2.42.5
Run reversals in cocaine runway, males0.50.51.81.3-0.60.5-1.2-1.21.20.6-0.6-0.4-0.4-0.0-0.20.30.3-0.3
Latency to leave start box in cocaine runway0.30.41.00.5-0.30.4-0.5-0.50.50.4-0.8-0.6-1.0-0.6-0.91.0-0.40.8
Latency to leave start box in cocaine runway, F0.10.10.20.40.00.0-0.3-0.30.30.1-0.3-0.1-0.4-0.0-0.30.40.20.1
Latency to leave start box in cocaine runway, M0.40.40.90.3-0.40.5-0.3-0.30.30.4-0.7-0.6-0.9-0.7-0.80.8-0.60.8
Std. dev. time between licks in bursts0.20.30.5-0.50.6-0.60.70.7-0.7-0.50.60.50.70.50.5-0.40.4-0.3
Total sessions with >9 infusions0.40.50.9-0.70.5-0.50.70.7-0.7-0.60.80.70.90.60.8-0.90.4-0.9
Short access day 1 total inactive lever presses0.30.51.2-1.00.9-0.71.11.1-1.1-0.90.60.30.50.20.2-0.10.10.4
Short access day 10 total inactive lever presses0.00.00.1-0.30.2-0.20.20.2-0.2-0.10.10.2-0.20.00.1-0.20.0-0.1
Short access day 1 total infusions0.10.20.40.3-0.50.6-0.5-0.50.50.5-0.4-0.6-0.2-0.6-0.50.5-0.60.4
Short access day 10 total infusions0.30.51.40.10.4-0.50.20.2-0.2-0.60.70.60.81.00.9-0.81.2-1.0
Short access total infusions0.20.30.80.10.2-0.3-0.0-0.00.0-0.40.60.40.90.80.7-0.70.9-0.8
Short access day 1 locomotion0.10.21.0-0.2-0.40.50.20.2-0.20.3-0.2-0.30.3-0.7-0.40.3-1.00.6
Short access day 10 total locomotion0.00.10.30.1-0.50.40.00.0-0.00.4-0.00.10.2-0.20.2-0.5-0.4-0.6
Short access total locomotion0.10.20.70.2-0.70.7-0.1-0.10.10.5-0.3-0.50.1-0.7-0.30.2-0.90.3
One hour access (0.3 mA shock)0.30.32.10.40.6-0.6-0.2-0.20.2-0.50.30.20.21.10.4-0.01.5-0.1
Compulsive drug intake0.10.20.6-0.20.7-0.70.10.1-0.1-0.60.30.3-0.10.60.2-0.00.8-0.1
One hour access (shock baseline)0.51.43.8-0.31.1-1.20.50.5-0.5-1.11.31.11.41.81.4-1.21.9-1.2
Social response proportion0.00.00.2-0.10.1-0.1-0.2-0.20.20.10.10.10.10.20.3-0.30.2-0.5
Social responses0.50.61.20.5-0.80.8-0.6-0.60.60.9-0.9-0.7-1.1-1.0-0.80.7-0.90.6
Social time0.81.34.0-0.40.8-1.00.30.3-0.3-0.71.11.30.81.31.5-1.61.5-2.0
Soleus weight0.51.42.61.0-1.21.3-0.9-0.90.91.0-1.1-1.4-0.5-1.2-1.31.4-1.21.6
Bone: stiffness0.81.53.31.2-1.81.6-1.3-1.31.31.5-1.2-0.9-1.4-1.2-0.70.3-1.2-0.1
Tibialis anterior weight6.321.829.15.4-5.15.0-5.2-5.25.25.1-4.8-5.0-3.5-4.1-4.44.4-3.53.5
Time to tail flick, vehicle, before self-admin0.20.31.80.1-0.40.2-0.0-0.00.00.40.20.60.30.20.7-1.00.2-1.3
Time to tail flick, vehicle, after self-admin2.96.09.6-2.02.1-2.32.12.1-2.1-2.12.72.53.12.52.8-2.82.3-2.7
Time to tail flick, test, before self-admin0.50.51.10.9-0.50.6-0.8-0.80.80.4-0.7-0.9-0.3-0.4-0.81.1-0.31.0
Time to tail flick, test, after self-admin1.61.72.5-0.91.3-1.31.11.1-1.1-1.31.41.31.61.51.4-1.21.5-1.2
Delta time to tail flick, vehicle, before/after SA5.55.98.1-2.42.6-2.62.42.4-2.4-2.62.62.32.92.42.4-2.22.1-1.8
Delta time to tail flick, test, before/after SA0.70.81.3-0.70.8-0.90.90.9-0.9-0.71.01.01.20.91.0-1.00.8-0.9
Tibia length0.00.10.3-0.1-0.40.30.20.2-0.20.6-0.10.1-0.1-0.30.1-0.4-0.5-0.4
Ambulatory time before self-admin1.95.77.52.2-2.72.7-2.3-2.32.32.7-2.5-2.5-2.5-2.5-2.32.0-2.31.6
Ambulatory time after self-admin2.74.35.41.9-2.22.2-1.8-1.81.82.1-2.3-2.2-2.3-2.2-2.22.1-2.01.9
Bone: tissue strength0.20.30.9-0.30.3-0.40.30.3-0.3-0.10.50.70.30.50.7-0.80.5-1.0
Total heroin consumption0.30.40.60.8-0.80.7-0.7-0.70.70.6-0.7-0.7-0.6-0.5-0.50.5-0.50.2
Bone: trabecular number1.42.63.8-1.01.7-1.71.21.2-1.2-1.71.81.61.92.01.8-1.62.0-1.6
Bone: trabecular spacing0.10.10.4-0.1-0.40.4-0.1-0.10.10.6-0.2-0.1-0.2-0.4-0.1-0.0-0.6-0.1
Bone: trabecular thickness0.30.41.2-0.40.9-0.80.70.7-0.7-1.10.50.40.10.60.3-0.10.70.1
Bone: trabecular tissue density1.42.45.10.6-1.81.8-0.9-0.90.91.7-1.7-1.4-2.3-2.1-1.51.1-2.21.1
Water consumed over 24 hours0.00.10.20.4-0.50.4-0.1-0.10.10.5-0.4-0.1-0.4-0.3-0.20.1-0.2-0.1
Number of responses in last shaping day0.10.10.30.0-0.20.3-0.1-0.10.10.2-0.1-0.40.2-0.4-0.30.3-0.50.4