Hub : Genes

Pde7a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Pde7a 0.03 0.02 5.3e-04 0.03 0.01 0.02 0.02 1.0e-04 2.9e-03 3.6e-04 6.9e-04
2 Adipose alternative TSS XM_039103227.2 0.03 0.02 1.9e-03 0.01 0 0.01 0.01 4.6e-02 7.4e-02 7.0e-02 5.7e-02
3 Adipose alternative TSS XM_039103227.2 0.03 0.02 6.5e-04 0.01 0.01 0.01 0.01 2.7e-02 3.2e-02 2.5e-02 1.6e-02
4 Adipose alternative polyA XM_006232188.5 0.02 0.02 8.2e-03 0.01 0.01 0 0 4.1e-02 5.8e-02 1.4e-01 1.0e-01
5 NAcc mRNA stability Pde7a 0.02 0.02 1.0e-03 0.02 0.01 0.01 0.01 6.7e-04 3.7e-03 2.3e-03 2.4e-03
6 PL gene expression Pde7a 0.08 0.07 3.0e-04 0.03 0.02 0.03 0.02 2.9e-04 3.6e-03 3.7e-04 2.4e-03
7 Brain gene expression Pde7a 0.07 0.04 1.8e-04 0.04 0.03 0.04 0.04 1.1e-04 9.4e-04 2.5e-04 1.3e-04
8 Adipose mRNA stability Pde7a 0.14 0.08 3.2e-13 0.08 0.08 0.08 0.07 4.7e-09 3.8e-09 6.6e-09 2.0e-08
9 Liver gene expression Pde7a 0.12 0.07 3.7e-12 0.07 0.07 0.07 0.08 3.0e-08 1.0e-08 1.1e-08 3.3e-09
10 Adipose isoform ratio XM_006232188.5 0.03 0.02 3.0e-03 0.01 0.01 0 0.01 1.1e-02 2.9e-02 7.9e-02 2.3e-02
11 Adipose alternative TSS XM_008760880.4 0.04 0.02 9.7e-04 0.01 0.01 0.01 0.01 2.8e-02 1.9e-02 6.7e-02 6.2e-02
12 Adipose gene expression Pde7a 0.1 0.05 4.8e-11 0.05 0.08 0.07 0.07 1.9e-06 3.9e-09 2.9e-08 1.8e-08
13 NAcc alternative TSS NM_031080.1 0.01 0.01 6.1e-03 0.01 0.01 0.01 0.01 2.0e-02 1.8e-02 3.2e-02 2.8e-02
14 Adipose alternative TSS XM_008760880.4 0.04 0.02 1.8e-03 0 0.01 0 0 9.1e-02 6.9e-02 1.3e-01 1.9e-01
15 NAcc alternative TSS XM_008760880.4 0.01 0.01 5.2e-03 0.01 0.01 0 0.01 1.6e-02 2.5e-02 5.7e-02 3.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.11.92.61.1-1.6-1.5-1.3-1.31.31.61.51.3-1.51.51.3-1.11.40.9
Area under the delay curve0.20.20.6-0.80.80.70.50.5-0.5-0.2-0.3-0.4-0.2-0.1-0.30.4-0.1-0.3
BMI with tail2.06.910.2-3.13.23.02.92.9-2.9-3.2-2.7-2.52.0-2.4-2.22.0-2.2-1.4
BMI without tail2.06.27.8-2.82.72.72.62.6-2.6-2.8-2.6-2.62.2-2.3-2.42.4-2.1-1.8
Body weight2.29.514.0-2.93.63.52.92.9-2.9-3.7-3.2-3.12.8-3.3-2.92.5-3.2-2.1
Weight adjusted by age0.40.51.3-0.30.80.80.10.1-0.1-0.7-0.8-0.70.8-1.0-0.80.7-1.1-0.8
Bone surface0.00.00.1-0.0-0.1-0.2-0.1-0.10.10.20.20.2-0.30.30.3-0.20.30.2
Bone volume0.00.00.00.0-0.1-0.1-0.1-0.10.10.10.10.1-0.10.10.1-0.00.2-0.0
Breakpoint value in progressive ratio session0.20.20.6-0.80.30.40.40.4-0.4-0.2-0.6-0.60.6-0.3-0.60.7-0.0-0.5
Number of licking bursts1.11.72.5-1.01.51.50.80.8-0.8-1.5-1.5-1.31.5-1.6-1.41.2-1.6-1.2
Context. condit. distance diff. score0.20.31.00.10.60.60.00.0-0.0-0.6-0.4-0.50.2-0.8-0.50.3-1.0-0.6
Locomotion velocity, session 10.40.40.9-0.70.60.61.01.0-1.0-0.5-0.5-0.70.2-0.4-0.50.6-0.3-0.5
Locomotion distance, session 10.20.30.9-0.40.0-0.10.30.3-0.30.10.40.4-0.70.70.7-0.70.81.0
Locomotion velocity, session 22.32.75.5-2.11.71.72.32.3-2.3-1.6-1.4-1.60.9-1.0-1.21.3-0.7-0.9
Locomotion distance, session 20.20.31.3-0.2-0.1-0.20.10.1-0.10.10.50.6-0.80.70.8-0.90.71.1
Locomotion velocity, session 31.01.21.9-1.21.41.31.21.2-1.2-1.3-1.1-1.10.7-1.0-0.90.9-0.9-0.7
Locomotion distance, session 30.90.91.3-1.11.11.10.90.9-0.9-1.2-1.0-1.00.5-0.9-1.01.0-0.9-0.9
Stereotopy head waving bouts, day 30.30.30.80.9-0.6-0.6-0.9-0.90.90.50.50.5-0.20.20.3-0.40.10.2
Stereotopy head waving duration, day 30.60.71.01.0-1.0-1.0-0.9-0.90.91.00.70.9-0.20.70.7-0.70.70.6
Locomotion velocity, session 72.93.24.42.1-1.9-1.9-2.0-2.02.01.71.81.9-1.51.41.8-1.91.11.6
Locomotion distance, session 72.63.35.12.3-2.2-2.2-2.1-2.12.12.01.81.8-1.31.41.6-1.61.11.2
Stereotopy head waving bouts, day 70.70.81.5-0.91.21.20.70.7-0.7-1.0-0.9-0.90.6-0.9-0.90.8-0.9-0.7
Stereotopy head waving duration, day 70.40.50.8-0.80.90.90.50.5-0.5-0.7-0.8-0.70.6-0.6-0.80.8-0.5-0.7
Locomotion velocity, session 81.11.32.8-1.31.31.31.71.7-1.7-1.3-1.0-1.10.4-0.8-0.80.7-0.7-0.5
Locomotion distance, session 80.91.42.3-1.21.51.41.31.3-1.3-1.5-1.1-1.20.6-1.1-0.90.7-1.1-0.5
Degree of sensitization distance4.95.07.32.4-2.7-2.7-2.2-2.22.22.62.32.4-1.52.12.2-2.12.01.8
Degree of sensitization stereotypy2.52.74.3-1.72.12.01.51.5-1.5-1.9-1.7-1.81.1-1.6-1.61.6-1.6-1.4
Conditioned locomotion2.12.53.61.3-1.5-1.5-1.3-1.31.31.61.81.6-1.91.71.8-1.71.51.6
Cocaine response after cond. corrected0.10.10.30.5-0.4-0.3-0.1-0.10.10.4-0.0-0.10.5-0.2-0.30.3-0.2-0.5
Cocaine response after cond. not corrected0.10.10.40.5-0.3-0.2-0.1-0.10.10.4-0.1-0.10.6-0.2-0.30.3-0.3-0.5
Cocaine response before conditioning0.30.40.60.5-0.5-0.6-0.5-0.50.50.50.60.7-0.60.60.7-0.80.60.8
Saline control response0.30.40.9-0.70.90.90.60.6-0.6-0.9-0.7-0.50.7-0.6-0.40.3-0.5-0.1
Bone: connectivity density1.62.54.80.8-1.9-1.9-1.1-1.11.11.91.71.5-1.82.11.6-1.22.21.1
Bone: cortical apparent density1.11.42.0-1.31.11.21.31.3-1.3-1.0-1.2-1.40.8-1.0-1.31.4-0.9-1.4
Bone: cortical area0.40.72.90.41.11.1-0.2-0.20.2-1.1-0.6-0.50.9-1.3-0.60.1-1.7-0.3
Bone: cortical porosity1.21.32.31.1-0.9-1.1-1.1-1.11.10.81.21.3-0.91.01.3-1.50.91.5
Bone: cortical porosity0.70.71.50.9-0.6-0.7-0.8-0.80.80.40.91.0-0.80.61.0-1.20.51.2
Bone: cortical thickness0.60.93.01.7-0.1-0.2-1.5-1.51.50.10.70.8-0.6-0.20.7-1.1-0.80.7
Bone: cortical thickness0.10.20.6-0.10.70.60.30.3-0.3-0.8-0.3-0.30.1-0.5-0.1-0.1-0.60.1
Bone: cortical tissue density1.31.82.6-1.51.21.31.51.5-1.5-1.1-1.3-1.60.9-1.1-1.41.6-1.0-1.5
Condit. Reinf. active minus inactive responses0.10.10.6-0.40.20.10.10.1-0.1-0.00.20.4-0.20.40.5-0.60.50.8
Condit. Reinf. active-inactive response ratio0.10.10.4-0.1-0.1-0.2-0.1-0.10.10.30.30.4-0.20.50.4-0.40.60.6
Condit. Reinf. active responses0.10.10.6-0.80.50.40.40.4-0.4-0.3-0.0-0.0-0.20.20.2-0.20.40.4
Condit. Reinf. inactive responses0.50.61.1-1.10.90.91.01.0-1.0-0.8-0.7-0.70.4-0.5-0.50.6-0.3-0.3
Incentive salience index mean0.10.10.6-0.80.60.50.40.4-0.4-0.4-0.3-0.20.3-0.1-0.10.10.00.1
Condit. Reinf. lever presses0.60.81.8-1.30.90.90.90.9-0.9-0.7-0.9-1.00.8-0.6-0.91.1-0.3-0.9
Condit. Reinf. active minus inactive responses0.00.00.10.10.30.2-0.1-0.10.1-0.40.00.0-0.3-0.20.1-0.3-0.30.3
Condit. Reinf. active-inactive response ratio0.00.00.4-0.10.10.10.10.1-0.1-0.20.1-0.1-0.60.00.1-0.1-0.10.1
Condit. Reinf. active responses0.10.20.50.50.0-0.1-0.5-0.50.5-0.10.30.5-0.20.00.5-0.7-0.10.7
Condit. Reinf. inactive responses0.10.10.40.60.20.2-0.5-0.50.5-0.2-0.00.30.6-0.40.1-0.4-0.50.3
Condit. Reinf. lever presses0.30.40.90.8-0.7-0.7-0.9-0.90.90.40.40.7-0.00.30.4-0.50.20.5
Condit. Reinf. lever reinforcers received0.10.20.50.40.1-0.0-0.4-0.40.4-0.10.30.4-0.20.00.4-0.7-0.10.7
Conditioned reinforcement - actives0.20.40.60.4-0.6-0.6-0.5-0.50.50.60.70.7-0.60.70.7-0.70.80.7
Conditioned reinforcement - inactives0.10.10.5-0.2-0.2-0.1-0.0-0.00.00.2-0.2-0.20.40.0-0.30.50.2-0.7
Conditioned locomotion0.20.30.7-0.50.40.60.20.2-0.2-0.3-0.6-0.70.5-0.5-0.70.8-0.4-0.8
Patch foraging indifference point 0 sec0.50.92.1-0.40.80.90.20.2-0.2-0.6-1.0-1.11.0-1.1-1.21.3-1.2-1.5
Patch foraging indifference point AUC0.40.61.70.0-0.5-0.60.20.2-0.20.40.80.6-1.31.01.0-0.91.01.0
Delay disc. indifference point, 0s delay0.10.10.20.30.40.3-0.1-0.10.1-0.40.10.1-0.3-0.20.2-0.4-0.40.4
Delay disc. indifference point, 16s delay0.40.41.1-0.1-0.4-0.5-0.3-0.30.30.70.70.6-1.10.80.7-0.60.80.6
Delay disc. indifference point, 2s delay0.20.20.6-0.10.80.80.20.2-0.2-0.3-0.4-0.60.2-0.5-0.50.6-0.6-0.6
Delay disc. indifference point, 24s delay0.91.01.60.9-0.7-0.7-1.1-1.11.11.21.21.1-1.31.11.0-0.91.00.7
Delay disc. indifference point, 4s delay2.22.34.4-2.12.01.91.91.9-1.9-1.4-1.4-1.40.7-0.9-1.21.3-0.6-0.8
Delay disc. indifference point, 8s delay0.20.31.1-1.00.60.60.60.6-0.6-0.2-0.3-0.50.1-0.1-0.40.50.0-0.4
Indifference point function ln k1.11.93.8-1.30.91.01.11.1-1.1-1.0-1.6-1.61.7-1.2-1.72.0-1.0-1.9
Indifference point function log k1.11.93.8-1.30.91.01.11.1-1.1-1.0-1.6-1.61.7-1.2-1.72.0-1.0-1.9
Patch foraging total patch changes 0 sec0.81.53.2-0.81.11.20.50.5-0.5-0.9-1.3-1.41.3-1.4-1.61.6-1.4-1.8
Patch foraging total patch changes 12 sec0.00.00.20.20.10.1-0.1-0.10.10.10.2-0.1-0.40.00.2-0.3-0.10.2
Patch foraging total patch changes 18 sec0.00.10.2-0.40.40.30.30.3-0.3-0.30.0-0.2-0.4-0.00.1-0.2-0.10.2
Patch foraging total patch changes 24 sec0.10.20.5-0.0-0.4-0.40.10.1-0.10.50.50.2-0.70.60.4-0.30.70.3
Patch foraging total patch changes 6 sec0.60.91.5-1.20.91.01.01.0-1.0-1.0-0.9-1.10.6-0.7-0.91.0-0.5-0.8
Patch foraging time to switch 0 sec0.00.00.00.10.00.0-0.1-0.10.1-0.00.00.10.2-0.00.1-0.2-0.00.2
Patch foraging water rate 0 sec0.30.51.0-0.90.50.60.90.9-0.9-0.5-0.6-0.80.2-0.4-0.81.0-0.3-1.0
Patch foraging water rate 12 sec0.30.71.10.6-0.8-0.8-0.7-0.70.70.60.91.0-0.80.90.9-0.90.81.0
Patch foraging water rate 18 sec0.10.10.20.3-0.4-0.4-0.3-0.30.30.40.40.4-0.30.40.3-0.30.40.3
Patch foraging water rate 24 sec0.20.20.80.1-0.5-0.5-0.1-0.10.10.60.60.5-0.90.70.5-0.30.70.3
Patch foraging water rate 6 sec0.81.22.3-0.70.80.90.70.7-0.7-0.9-1.2-1.01.3-1.2-1.41.5-1.1-1.5
Seeking ratio, delayed vs. immediate footshock2.32.85.12.3-2.2-2.0-1.9-1.91.92.11.71.4-1.31.31.2-1.11.00.4
Distance traveled before self-admin4.96.48.9-2.53.02.92.52.5-2.5-3.0-2.7-2.62.4-2.6-2.42.1-2.5-1.7
Distance traveled after self-admin7.79.512.4-2.73.33.32.72.7-2.7-3.2-3.4-3.23.5-3.3-3.23.1-3.1-2.7
Extensor digitorum longus weight5.923.231.5-5.65.35.25.55.5-5.5-5.3-4.9-5.03.8-4.1-4.34.2-3.6-3.3
Bone: elastic displacement2.02.34.11.5-1.6-1.6-1.6-1.61.61.41.71.5-2.01.51.5-1.41.21.1
Bone: elastic work0.40.60.90.9-0.9-0.8-0.9-0.90.90.70.80.6-0.90.60.6-0.50.50.2
Bone: endosteal estimation1.22.73.8-1.91.91.82.02.0-2.0-1.9-1.7-1.51.7-1.4-1.31.1-1.1-0.6
Bone: endosteal perimeter1.73.66.1-1.12.12.11.31.3-1.3-2.0-2.1-1.92.5-2.4-2.01.7-2.4-1.6
Epididymis fat weight2.27.79.2-2.33.03.02.72.7-2.7-3.0-2.9-2.92.7-3.0-2.72.5-3.0-2.2
Delta time in closed arm before/after self-admin0.50.50.90.2-0.5-0.6-0.4-0.40.40.60.70.7-0.80.90.8-0.80.90.9
Delta time in open arm before/after self-admin0.20.20.70.40.10.1-0.1-0.10.1-0.1-0.2-0.20.4-0.6-0.40.3-0.8-0.6
Diff in mean of infusions in LGA sessions0.20.20.40.2-0.5-0.5-0.4-0.40.40.60.40.5-0.40.60.4-0.30.60.3
Delay discount exponential model param0.20.20.60.7-0.8-0.8-0.5-0.50.50.20.30.40.00.20.3-0.40.10.3
Extinction: sum of active levers before priming0.10.10.20.3-0.4-0.4-0.3-0.30.30.40.30.2-0.20.20.2-0.20.20.1
Active lever presses in extinction session 60.60.61.4-0.71.21.00.80.8-0.8-1.1-0.8-0.40.9-0.8-0.30.0-0.70.4
Bone: final force0.60.92.3-0.81.51.40.80.8-0.8-1.4-0.9-0.71.0-1.1-0.60.2-1.20.0
Bone: final moment0.50.82.1-0.61.51.30.70.7-0.7-1.3-0.9-0.61.0-1.1-0.50.1-1.20.1
Food consumed during 24 hour testing period3.44.76.3-2.52.42.42.32.3-2.3-2.5-2.3-2.22.1-1.9-2.01.9-1.6-1.4
Glucose0.30.41.2-0.61.00.90.40.4-0.4-1.1-0.7-0.40.6-0.7-0.40.2-0.70.0
Heart weight0.61.01.5-1.21.01.01.01.0-1.0-0.9-1.0-1.10.8-0.8-1.11.2-0.6-1.1
Delay discount hyperbolic model param0.30.31.00.8-1.0-0.9-0.6-0.60.60.40.40.5-0.10.30.4-0.50.30.4
Intermittent access intake day 1-15 change0.10.20.8-0.80.40.30.90.9-0.9-0.6-0.2-0.2-0.20.20.10.00.40.2
Intermittent access intake escalation0.10.30.8-0.80.40.40.90.9-0.9-0.6-0.2-0.3-0.10.1-0.00.10.30.1
Intermittent access intake escalation 20.10.20.5-0.60.40.30.70.7-0.7-0.5-0.2-0.20.00.0-0.00.00.20.2
Intermitt. access day 1 inactive lever presses0.10.41.2-1.10.60.51.11.1-1.1-0.5-0.5-0.40.70.0-0.20.30.3-0.0
Intermitt. access day 15 inactive lever presses0.30.62.1-0.1-0.6-0.70.10.1-0.10.60.70.7-0.71.20.9-0.81.41.0
Intermitt. access escalation Index0.20.31.00.5-0.9-0.8-0.5-0.50.51.00.40.50.50.60.3-0.10.80.1
Intermittent access day 1 total infusions0.20.21.0-0.2-0.3-0.40.00.0-0.00.40.50.3-0.60.80.5-0.41.00.6
Intermittent access day 15 total infusions0.60.93.1-0.3-0.5-0.60.20.2-0.20.50.90.7-1.31.51.2-1.01.81.3
Intermittent access terminal intake (last 3 days)0.70.92.9-1.10.0-0.10.90.9-0.9-0.10.50.3-1.11.30.9-0.81.71.3
Intermittent access total infusions1.01.24.3-0.4-0.7-0.80.20.2-0.20.71.00.8-1.41.81.3-1.02.11.4
Intermittent access day 1 locomotion0.10.10.1-0.40.40.40.30.3-0.3-0.3-0.1-0.3-0.4-0.1-0.10.1-0.20.0
Intermittent access day 15 total locomotion0.20.30.5-0.70.60.60.60.6-0.6-0.6-0.5-0.70.2-0.4-0.50.5-0.3-0.4
Intermittent access total locomotion0.10.20.3-0.60.50.50.50.5-0.5-0.5-0.4-0.60.0-0.2-0.40.4-0.2-0.3
Intermittent access standard deviation0.20.30.9-0.90.50.40.90.9-0.9-0.6-0.2-0.2-0.00.20.1-0.00.40.3
Left kidney weight0.31.42.2-0.81.11.20.60.6-0.6-1.2-1.3-1.31.0-1.4-1.41.4-1.5-1.5
Right kidney weight0.73.05.4-1.21.91.91.01.0-1.0-2.0-1.9-1.81.6-2.2-1.91.7-2.3-1.6
Cocaine induced anxiety0.10.20.40.4-0.0-0.1-0.5-0.50.50.00.30.5-0.40.20.5-0.70.00.7
Post-drug Anxiety0.60.61.60.6-0.5-0.6-0.5-0.50.50.50.81.0-0.70.71.0-1.20.61.3
Baseline Anxiety0.10.20.4-0.60.20.20.60.6-0.6-0.2-0.4-0.40.4-0.1-0.40.50.1-0.3
Tail length0.41.42.5-0.61.01.10.60.6-0.6-1.1-1.3-1.31.5-1.5-1.41.3-1.6-1.4
Length with tail0.73.05.0-1.11.91.91.11.1-1.1-2.0-1.9-1.82.1-2.2-1.81.5-2.2-1.5
Length without tail0.82.44.3-1.11.91.91.21.2-1.2-2.1-1.6-1.61.4-1.9-1.41.1-2.0-1.0
Times rat made contact with spout3.84.47.7-1.22.22.31.31.3-1.3-2.3-2.3-2.12.8-2.6-2.31.9-2.7-1.9
Lifetime Intake0.91.13.8-0.3-0.6-0.70.20.2-0.20.71.00.7-1.41.71.3-1.02.01.3
Liver weight, left0.50.92.2-1.11.51.30.80.8-0.8-1.3-1.0-0.60.9-0.9-0.60.4-0.8-0.0
Liver weight, right4.27.39.4-2.62.82.82.82.8-2.8-2.8-2.9-2.83.1-2.6-2.62.4-2.3-2.0
Locomotor activity0.40.61.2-0.81.11.00.70.7-0.7-1.0-0.9-0.70.8-0.8-0.70.5-0.8-0.3
Locomotor testing distance0.50.91.8-0.61.41.30.70.7-0.7-1.3-1.0-0.71.0-1.2-0.80.5-1.2-0.3
Locomotor testing rearing0.10.20.80.8-0.1-0.2-0.5-0.50.50.20.40.60.1-0.00.5-0.8-0.20.9
Locomotion in novel chamber0.20.30.7-0.10.80.80.20.2-0.2-0.7-0.5-0.30.4-0.7-0.40.3-0.8-0.3
Locomotion in novel chamber post-restriction0.71.22.00.5-1.2-1.2-0.6-0.60.61.01.11.2-1.21.31.2-1.21.41.3
Fecal boli incidents, locomotor time 10.81.14.2-0.0-0.6-0.8-0.2-0.20.20.61.01.2-0.81.21.4-1.61.42.0
Change in fecal boli incidents, locomotor task1.21.24.12.0-0.9-0.8-1.7-1.71.70.80.80.7-0.5-0.00.4-0.6-0.5-0.3
Time >=10cm from walls, locomotor time 10.40.40.60.7-0.8-0.8-0.7-0.70.70.60.60.5-0.20.50.6-0.70.30.5
Bouts of movement, locomotor time 10.30.41.0-0.1-0.8-0.80.10.1-0.10.70.60.2-1.00.90.5-0.21.00.3
Total resting periods, locomotor time 10.40.41.2-0.2-0.9-0.80.00.0-0.00.70.60.2-1.11.00.5-0.21.10.2
Rest time, locomotor task time 10.50.62.0-1.40.0-0.11.11.1-1.1-0.20.10.1-0.60.80.6-0.61.11.1
Distance moved, locomotor task time 10.71.12.81.10.30.5-0.7-0.70.7-0.2-0.8-0.61.7-1.4-1.21.0-1.6-1.5
Vertical activity count, locomotor time 10.92.15.50.21.11.20.00.0-0.0-0.7-1.4-1.32.3-1.9-1.81.8-1.9-2.1
Time >=10cm from walls, locomotor time 20.60.91.81.1-0.6-0.7-1.3-1.31.30.71.00.9-0.60.51.0-1.30.20.7
Bouts of movement, locomotor time 20.20.31.2-0.6-0.3-0.30.20.2-0.20.50.50.2-1.10.80.4-0.10.90.3
Total resting periods, locomotor time 20.20.31.2-0.8-0.2-0.30.40.4-0.40.40.40.1-1.10.80.3-0.00.90.3
Rest time, locomotor task time 20.81.03.3-1.1-0.4-0.60.70.7-0.70.50.60.6-1.21.41.0-0.81.81.4
Distance moved, locomotor task time 20.40.52.01.4-0.3-0.2-1.1-1.11.10.40.10.30.8-0.4-0.20.0-0.7-0.4
Vertical activity count, locomotor time 21.01.44.0-0.91.01.00.90.9-0.9-0.8-1.3-1.12.0-1.2-1.41.4-1.0-1.1
Light reinforcement 10.51.31.7-0.81.31.31.11.1-1.1-1.2-1.1-1.21.0-1.3-1.11.0-1.3-1.0
Light reinforcement 24.67.011.7-1.12.32.51.61.6-1.6-2.3-2.8-2.83.1-3.3-3.23.0-3.4-3.4
Bone: marrow area1.22.74.0-2.01.91.82.02.0-2.0-1.9-1.7-1.51.7-1.4-1.31.1-1.0-0.6
Bone: maximum diameter0.71.43.9-0.11.51.40.40.4-0.4-1.4-1.2-1.01.6-1.7-1.10.7-2.0-0.8
Bone: maximum force0.71.22.5-1.01.61.41.11.1-1.1-1.5-1.1-0.81.2-1.1-0.60.3-1.00.1
Bone: maximum moment0.50.92.2-0.91.51.30.90.9-0.9-1.4-0.9-0.61.1-1.0-0.50.1-1.00.2
Mean time between licks in bursts0.30.82.0-1.40.50.51.41.4-1.4-0.5-0.8-0.80.7-0.2-0.60.80.2-0.4
Mean num. licks in bursts0.00.00.20.4-0.2-0.2-0.2-0.20.20.10.20.20.10.00.2-0.3-0.00.3
Cd content in liver0.70.82.1-1.41.11.01.31.3-1.3-1.1-0.7-0.60.3-0.3-0.20.1-0.10.4
Co content in liver1.11.23.3-0.61.11.10.90.9-0.9-1.2-1.2-0.91.8-1.4-1.10.9-1.3-0.8
Cu content in liver0.20.30.70.8-0.5-0.5-0.8-0.80.80.50.40.5-0.10.10.3-0.4-0.00.3
Fe content in liver0.30.30.91.0-0.2-0.3-0.7-0.70.70.20.40.6-0.2-0.00.5-0.8-0.20.8
K content in liver0.60.61.11.0-1.0-0.9-0.9-0.90.91.00.70.7-0.30.50.4-0.40.50.1
Mg content in liver0.40.40.80.7-0.9-0.8-0.8-0.80.80.90.50.5-0.40.50.3-0.10.4-0.1
Mn content in liver0.00.00.1-0.30.00.00.20.2-0.2-0.0-0.1-0.1-0.10.1-0.10.20.1-0.2
Na content in liver0.70.71.7-0.10.80.90.20.2-0.2-0.8-0.9-0.80.8-1.2-1.01.0-1.3-1.1
Rb content in liver1.61.93.01.7-1.2-1.3-1.6-1.61.61.21.41.6-1.00.91.4-1.70.61.6
Se content in liver0.10.10.40.6-0.1-0.2-0.5-0.50.50.10.30.4-0.1-0.10.3-0.4-0.30.3
Sr content in liver1.00.82.30.4-1.1-1.0-0.7-0.70.71.10.90.8-0.81.30.8-0.51.50.4
Zn content in liver0.10.10.30.2-0.6-0.5-0.4-0.40.40.50.20.10.10.30.00.10.4-0.2
Bone: minimum diameter0.51.02.2-0.51.21.20.50.5-0.5-1.0-1.1-0.91.5-1.3-1.00.8-1.4-0.8
Time in familiar zone, hab. session 10.10.10.30.3-0.3-0.3-0.5-0.50.50.50.10.40.50.20.1-0.10.40.2
Time in novel zone, hab. session 10.30.30.5-0.60.60.60.60.6-0.6-0.6-0.5-0.7-0.1-0.5-0.50.5-0.6-0.5
Total zone transitions, hab. session 10.10.10.4-0.30.10.10.40.4-0.40.00.2-0.2-0.60.20.1-0.00.2-0.0
Total locomotion distance, hab. session 10.00.00.40.00.20.10.10.1-0.1-0.10.1-0.1-0.60.10.1-0.1-0.0-0.0
Locomotion velocity, hab. session 10.10.10.1-0.20.40.40.30.3-0.3-0.3-0.1-0.3-0.4-0.2-0.20.3-0.2-0.3
Time in familiar zone, hab. session 20.30.30.60.8-0.8-0.7-0.6-0.60.60.70.30.50.30.30.2-0.10.30.0
Time in novel zone, hab. session 20.40.41.10.0-0.3-0.4-0.3-0.30.30.40.70.6-1.00.80.8-0.80.80.9
Total zone transitions, hab. session 20.20.30.6-0.60.70.70.50.5-0.5-0.7-0.5-0.60.1-0.5-0.40.4-0.5-0.4
Total locomotion distance, hab. session 20.00.00.1-0.00.20.2-0.1-0.10.1-0.10.10.0-0.3-0.00.1-0.1-0.10.1
Locomotion velocity, hab. session 20.00.10.2-0.10.40.4-0.0-0.00.0-0.2-0.1-0.2-0.2-0.2-0.20.2-0.3-0.3
Novel to familiar place preference ratio2.22.43.91.3-1.5-1.5-1.2-1.21.21.51.71.6-2.01.61.7-1.71.51.5
Novelty place preference1.92.03.41.2-1.4-1.4-1.2-1.21.21.51.61.4-1.91.51.5-1.51.41.3
Time in novel zone, NPP test1.51.72.71.0-1.2-1.3-1.1-1.11.11.31.41.3-1.61.41.4-1.41.21.2
Total zone transitions, NPP test0.10.20.6-0.10.0-0.1-0.1-0.10.10.10.40.4-0.70.50.6-0.60.50.7
Total locomotion distance, NPP test0.00.10.20.20.10.0-0.2-0.20.20.00.30.3-0.40.20.3-0.40.10.4
Locomotion velocity, NPP test0.30.50.90.6-0.5-0.5-0.5-0.50.50.60.80.7-0.90.70.8-0.90.60.8
Intraocular pressure0.70.92.2-1.31.01.01.51.5-1.5-1.0-0.8-1.00.4-0.5-0.60.7-0.4-0.4
Delta distance traveled before/after self-admin0.10.10.30.00.10.10.00.0-0.00.0-0.2-0.30.3-0.3-0.40.4-0.3-0.5
Delta ambulatory time before/after self-admin0.20.20.40.6-0.5-0.5-0.6-0.60.60.60.30.3-0.20.1-0.00.10.0-0.5
Parametrial fat weight3.27.610.0-2.33.23.12.62.6-2.6-3.1-2.9-2.82.8-3.0-2.72.4-3.0-2.1
Pavlov. Cond. lever latency0.30.41.51.2-0.6-0.6-0.8-0.80.80.20.60.6-0.70.10.6-0.7-0.20.5
Pavlov. Cond. magazine entry latency0.60.72.9-1.70.50.51.11.1-1.1-0.3-0.8-0.80.60.0-0.71.10.5-0.7
Pavlov. Cond. change in total contacts2.72.95.9-2.41.81.82.02.0-2.0-1.5-1.7-1.71.5-1.1-1.51.7-0.7-1.2
Pavlov. Cond. index score1.51.95.3-2.31.31.31.71.7-1.7-0.9-1.4-1.41.2-0.6-1.31.6-0.1-1.2
Pavlov. Cond. latency score0.91.13.7-1.91.01.01.31.3-1.3-0.7-1.0-1.00.9-0.3-0.91.10.1-0.7
Pavlov. Cond. lever contacts0.91.03.1-1.70.70.81.21.2-1.2-0.4-0.9-1.00.8-0.3-0.91.30.2-1.0
Pavlov. Cond. magazine entry number1.92.45.82.4-1.3-1.3-1.8-1.81.81.01.61.7-1.40.71.5-1.90.21.5
Pavlov. Cond. intertrial magazine entries0.30.30.90.8-0.5-0.5-0.6-0.60.60.50.70.5-1.00.30.5-0.50.10.3
Pavlov. Cond. lever-magazine prob. diff.2.22.86.5-2.51.51.51.91.9-1.9-1.2-1.7-1.71.5-0.9-1.61.9-0.3-1.5
Pavlov. Cond. response bias2.22.76.4-2.51.31.42.02.0-2.0-1.0-1.7-1.81.4-0.8-1.72.1-0.2-1.7
Pavlov. Cond. lever latency0.30.41.3-1.10.10.11.11.1-1.10.10.0-0.3-0.60.60.10.20.90.1
Pavlov. Cond. magazine entry latency0.20.30.7-0.40.30.40.30.3-0.3-0.5-0.6-0.50.8-0.5-0.60.7-0.4-0.6
Pavlov. Cond. change in total contacts0.20.31.01.0-0.1-0.2-0.9-0.90.90.00.30.5-0.0-0.20.3-0.6-0.50.4
Pavlov. Cond. index score0.20.30.90.20.40.5-0.1-0.10.1-0.6-0.6-0.40.9-0.9-0.60.5-1.0-0.6
Pavlov. Cond. latency score0.20.30.80.20.40.4-0.1-0.10.1-0.5-0.5-0.30.9-0.8-0.50.4-0.9-0.5
Pavlov. Cond. lever contacts0.30.51.31.2-0.1-0.1-1.1-1.11.1-0.1-0.10.30.6-0.7-0.2-0.1-1.0-0.2
Pavlov. Cond. magazine entry number0.10.10.5-0.1-0.3-0.3-0.1-0.10.10.40.40.2-0.70.50.4-0.20.60.3
Pavlov. Cond. intertrial magazine entries0.30.40.80.4-0.7-0.7-0.4-0.40.40.80.70.6-0.90.80.7-0.60.80.6
Pavlov. Cond. lever-magazine prob. diff.0.30.41.10.00.60.60.10.1-0.1-0.7-0.7-0.51.0-1.0-0.80.6-1.1-0.7
Pavlov. Cond. response bias0.20.30.90.70.10.1-0.8-0.80.8-0.3-0.30.00.8-0.8-0.30.1-1.0-0.3
Time in closed arm before self-admin0.10.10.5-0.5-0.00.10.20.2-0.20.1-0.3-0.40.2-0.0-0.40.70.2-0.7
Time in closed arm after self-admin0.10.10.5-0.1-0.5-0.4-0.2-0.20.20.60.10.10.30.4-0.00.20.7-0.2
Time in open arm before self-admin0.30.40.6-0.30.70.70.60.6-0.6-0.7-0.6-0.50.8-0.7-0.50.3-0.7-0.2
Time in open arm after self-admin0.91.02.4-0.31.11.10.80.8-0.8-1.2-1.0-1.00.9-1.4-1.00.7-1.6-0.8
Bone: periosteal estimation0.92.03.4-0.91.91.81.11.1-1.1-1.8-1.5-1.21.8-1.7-1.20.8-1.8-0.7
Bone: periosteal perimeter1.22.15.8-0.11.71.70.40.4-0.4-1.6-1.5-1.31.9-2.1-1.41.0-2.4-1.2
Bone: post-yield work0.81.12.3-1.41.11.01.51.5-1.5-1.3-1.1-0.71.3-0.6-0.60.4-0.30.2
Progressive ratio test 1 active lever presses0.20.30.8-0.90.60.50.70.7-0.7-0.5-0.1-0.2-0.60.20.2-0.20.30.5
Progressive ratio test 1 breakpoint0.20.30.8-0.90.60.50.70.7-0.7-0.5-0.0-0.2-0.60.30.3-0.20.40.5
Progressive ratio test 1 inactive lever presses0.50.81.40.5-1.0-0.9-0.6-0.60.61.01.00.9-0.91.10.9-0.81.20.6
Progressive ratio test 2 active lever presses0.20.21.3-0.2-0.2-0.20.00.0-0.00.20.50.2-1.20.70.5-0.40.80.4
Progressive ratio test 2 breakpoint0.10.20.9-0.3-0.1-0.10.10.1-0.10.10.30.1-1.00.60.4-0.20.70.2
Progressive ratio test 2 inactive lever presses0.30.52.1-0.3-0.4-0.50.20.2-0.20.40.70.6-0.81.20.9-0.71.51.0
Incentive Sensitization - Responses0.10.20.8-0.0-0.5-0.5-0.1-0.10.10.50.40.2-0.60.70.4-0.10.90.1
Incentive Sensitization - Breakpoint0.10.10.6-0.1-0.4-0.40.00.0-0.00.40.30.1-0.40.60.20.00.8-0.1
Sum of active levers in priming session hrs 5-60.70.60.9-0.70.80.80.80.8-0.8-0.7-0.8-0.91.0-0.8-0.80.7-0.8-0.6
Progressive ratio0.60.91.60.6-1.0-1.1-0.7-0.70.70.91.01.1-0.71.01.2-1.30.91.2
Food seeking constrained by brief footshock0.20.30.70.3-0.9-0.8-0.2-0.20.20.80.40.5-0.20.70.4-0.20.80.2
Seeking ratio, punishment vs. effort0.20.31.1-0.20.30.40.30.3-0.3-0.2-0.5-0.60.4-0.4-0.81.0-0.4-1.0
Retroperitoneal fat weight1.14.66.1-2.42.52.42.52.5-2.5-2.3-2.1-2.21.5-1.9-1.91.9-1.7-1.5
Reaction time number correct0.91.83.92.0-1.2-1.2-1.8-1.81.81.21.31.5-0.70.71.2-1.40.41.1
Reaction time mean minus median3.17.713.3-3.62.52.53.63.6-3.6-2.5-2.8-2.92.3-1.8-2.52.8-1.2-2.2
Reaction time mean minus median AUC2.76.912.9-3.62.32.33.53.5-3.5-2.4-2.6-2.62.0-1.6-2.32.5-1.0-1.8
Reaction time num false alarms3.14.36.92.5-1.7-1.8-2.6-2.62.61.72.12.3-1.61.42.1-2.40.92.0
Reaction time num false alarms AUC2.33.56.42.5-1.5-1.5-2.5-2.52.51.51.82.0-1.31.11.8-2.10.61.6
Reaction time trials correct on left0.91.83.92.0-1.2-1.2-1.8-1.81.81.21.31.5-0.70.71.2-1.40.41.1
Reaction time trials on left0.91.83.81.9-1.1-1.2-1.8-1.81.81.11.21.5-0.60.71.2-1.40.31.1
Reaction time mean0.91.53.8-1.60.90.92.02.0-2.0-1.0-1.1-1.01.1-0.6-0.90.9-0.2-0.5
Reaction time mean AUC0.71.12.9-1.40.70.71.71.7-1.7-0.7-0.9-0.81.0-0.4-0.70.8-0.0-0.4
Median of all reaction times0.20.31.1-0.60.20.21.11.1-1.1-0.3-0.3-0.20.5-0.0-0.10.10.20.2
Reaction time omissions0.50.71.2-1.11.00.91.01.0-1.0-0.9-0.9-0.60.9-0.6-0.60.4-0.5-0.1
Reaction time false alarm rate0.71.02.01.3-0.7-0.7-1.4-1.41.40.70.90.9-0.80.50.9-1.10.20.8
Reaction time premature initiation rate0.20.20.8-0.3-0.5-0.50.20.2-0.20.70.40.1-0.70.70.3-0.00.9-0.0
Reaction time premature initiations0.30.51.00.4-0.8-0.8-0.4-0.40.41.00.80.6-0.80.90.6-0.50.90.3
Std. dev. reaction times2.44.48.1-2.71.91.92.82.8-2.8-2.0-2.1-2.01.9-1.4-1.81.9-0.9-1.3
Reaction time trials completed0.91.83.81.9-1.1-1.2-1.8-1.81.81.11.21.5-0.60.71.2-1.40.31.1
Reaction time trials AUC0.81.43.21.8-1.0-1.0-1.6-1.61.61.01.11.4-0.50.51.1-1.30.21.0
Run reversals in cocaine runway, females6.06.07.2-2.22.52.62.02.0-2.0-2.3-2.7-2.62.7-2.6-2.72.7-2.4-2.5
Run reversals in cocaine runway, males0.50.51.8-1.30.60.51.21.2-1.2-0.6-0.6-0.40.4-0.0-0.20.30.30.3
Latency to leave start box in cocaine runway0.40.41.0-0.50.30.40.50.5-0.5-0.4-0.8-0.61.0-0.6-0.91.0-0.4-0.8
Latency to leave start box in cocaine runway, F0.10.10.2-0.4-0.00.00.30.3-0.3-0.1-0.3-0.10.4-0.0-0.30.40.2-0.1
Latency to leave start box in cocaine runway, M0.40.40.9-0.30.40.50.30.3-0.3-0.4-0.7-0.60.9-0.7-0.80.8-0.6-0.8
Std. dev. time between licks in bursts0.20.30.50.5-0.6-0.6-0.7-0.70.70.50.60.5-0.70.50.5-0.40.40.3
Total sessions with >9 infusions0.40.50.90.7-0.5-0.5-0.7-0.70.70.60.80.7-0.90.60.8-0.90.40.9
Short access day 1 total inactive lever presses0.40.51.21.0-0.9-0.7-1.1-1.11.10.90.60.3-0.50.20.2-0.10.1-0.4
Short access day 10 total inactive lever presses0.00.00.10.3-0.2-0.2-0.2-0.20.20.10.10.20.20.00.1-0.20.00.1
Short access day 1 total infusions0.20.20.4-0.30.50.60.50.5-0.5-0.5-0.4-0.60.2-0.6-0.50.5-0.6-0.4
Short access day 10 total infusions0.40.51.4-0.1-0.4-0.5-0.2-0.20.20.60.70.6-0.81.00.9-0.81.21.0
Short access total infusions0.30.30.8-0.1-0.2-0.30.00.0-0.00.40.60.4-0.90.80.7-0.70.90.8
Short access day 1 locomotion0.20.21.00.20.40.5-0.2-0.20.2-0.3-0.2-0.3-0.3-0.7-0.40.3-1.0-0.6
Short access day 10 total locomotion0.10.10.3-0.10.50.4-0.0-0.00.0-0.4-0.00.1-0.2-0.20.2-0.5-0.40.6
Short access total locomotion0.20.20.7-0.20.70.70.10.1-0.1-0.5-0.3-0.5-0.1-0.7-0.30.2-0.9-0.3
One hour access (0.3 mA shock)0.30.32.1-0.4-0.6-0.60.20.2-0.20.50.30.2-0.21.10.4-0.01.50.1
Compulsive drug intake0.20.20.60.2-0.7-0.7-0.1-0.10.10.60.30.30.10.60.2-0.00.80.1
One hour access (shock baseline)0.91.43.80.3-1.1-1.2-0.5-0.50.51.11.31.1-1.41.81.4-1.21.91.2
Social response proportion0.00.00.20.1-0.1-0.10.20.2-0.2-0.10.10.1-0.10.20.3-0.30.20.5
Social responses0.50.61.2-0.50.80.80.60.6-0.6-0.9-0.9-0.71.1-1.0-0.80.7-0.9-0.6
Social time0.91.34.00.4-0.8-1.0-0.3-0.30.30.71.11.3-0.81.31.5-1.61.52.0
Soleus weight0.51.42.6-1.01.21.30.90.9-0.9-1.0-1.1-1.40.5-1.2-1.31.4-1.2-1.6
Bone: stiffness0.91.53.3-1.21.81.61.31.3-1.3-1.5-1.2-0.91.4-1.2-0.70.3-1.20.1
Tibialis anterior weight6.421.829.1-5.45.15.05.25.2-5.2-5.1-4.8-5.03.5-4.1-4.44.4-3.5-3.5
Time to tail flick, vehicle, before self-admin0.30.31.8-0.10.40.20.00.0-0.0-0.40.20.6-0.30.20.7-1.00.21.3
Time to tail flick, vehicle, after self-admin4.56.09.62.0-2.1-2.3-2.1-2.12.12.12.72.5-3.12.52.8-2.82.32.7
Time to tail flick, test, before self-admin0.50.51.1-0.90.50.60.80.8-0.8-0.4-0.7-0.90.3-0.4-0.81.1-0.3-1.0
Time to tail flick, test, after self-admin1.61.72.50.9-1.3-1.3-1.1-1.11.11.31.41.3-1.61.51.4-1.21.51.2
Delta time to tail flick, vehicle, before/after SA6.25.98.12.4-2.6-2.6-2.4-2.42.42.62.62.3-2.92.42.4-2.22.11.8
Delta time to tail flick, test, before/after SA0.80.81.30.7-0.8-0.9-0.9-0.90.90.71.01.0-1.20.91.0-1.00.80.9
Tibia length0.00.10.30.10.40.3-0.2-0.20.2-0.6-0.10.10.1-0.30.1-0.4-0.50.4
Ambulatory time before self-admin3.85.77.5-2.22.72.72.32.3-2.3-2.7-2.5-2.52.5-2.5-2.32.0-2.3-1.6
Ambulatory time after self-admin3.74.35.4-1.92.22.21.81.8-1.8-2.1-2.3-2.22.3-2.2-2.22.1-2.0-1.9
Bone: tissue strength0.30.30.90.3-0.3-0.4-0.3-0.30.30.10.50.7-0.30.50.7-0.80.51.0
Total heroin consumption0.30.40.6-0.80.80.70.70.7-0.7-0.6-0.7-0.70.6-0.5-0.50.5-0.5-0.2
Bone: trabecular number1.62.63.81.0-1.7-1.7-1.2-1.21.21.71.81.6-1.92.01.8-1.62.01.6
Bone: trabecular spacing0.10.10.40.10.40.40.10.1-0.1-0.6-0.2-0.10.2-0.4-0.1-0.0-0.60.1
Bone: trabecular thickness0.30.41.20.4-0.9-0.8-0.7-0.70.71.10.50.4-0.10.60.3-0.10.7-0.1
Bone: trabecular tissue density1.62.45.1-0.61.81.80.90.9-0.9-1.7-1.7-1.42.3-2.1-1.51.1-2.2-1.1
Water consumed over 24 hours0.10.10.2-0.40.50.40.10.1-0.1-0.5-0.4-0.10.4-0.3-0.20.1-0.20.1
Number of responses in last shaping day0.10.10.3-0.00.20.30.10.1-0.1-0.2-0.1-0.4-0.2-0.4-0.30.3-0.5-0.4