Pde6c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Pde6c	0.03	0.02	7.5e-03	0.01	0.02	0	0.01	5.0e-02	5.4e-03	1.8e-01	1.0e-01
2	Adipose	gene expression	Pde6c	0.11	0.04	0.0e+00	0.11	0.13	0.12	0.13	4.2e-12	1.6e-14	9.1e-14	3.9e-14
3	Liver	gene expression	Pde6c	0.06	0.04	7.3e-05	0.03	0.02	0.02	0.03	1.9e-04	2.4e-03	2.4e-03	6.3e-04
4	Adipose	mRNA stability	Pde6c	0.04	0.02	6.8e-05	0.03	0.03	0.01	0.03	2.6e-04	4.2e-04	3.7e-02	8.5e-04
5	Liver	isoform ratio	NM_001416003.1	0.06	0.03	5.2e-03	0.02	0.02	0	0.01	2.8e-03	1.6e-03	1.2e-01	1.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.5	4.6	7.5	2.4	2.7	2.7	-1.2	-1.1
Area under the delay curve	0.4	0.7	1.5	-1.1	-0.7	-0.2	1.2	-0.4
BMI with tail	0.3	1.0	2.8	-0.0	0.4	0.7	-1.2	-1.7
BMI without tail	0.0	0.1	0.4	-0.1	-0.2	-0.4	-0.6	0.1
Body weight	0.5	2.1	4.2	1.8	0.8	0.2	-1.6	2.0
Weight adjusted by age	0.1	0.3	0.8	-0.7	-0.3	0.3	-0.1	-0.9
Bone surface	2.2	4.4	7.2	2.4	2.7	2.4	-1.6	-0.8
Bone volume	2.4	4.8	7.3	2.7	2.7	2.6	-1.8	-0.3
Breakpoint value in progressive ratio session	0.3	0.5	1.1	-0.1	-0.3	-0.4	1.0	1.0
Number of licking bursts	0.8	2.4	4.4	-2.1	-1.5	-1.1	1.7	-1.1
Context. condit. distance diff. score	1.3	1.5	2.8	1.7	1.5	1.3	-1.0	0.4
Locomotion velocity, session 1	3.1	3.5	5.3	-2.3	-1.4	-1.1	2.2	-1.9
Locomotion distance, session 1	1.0	1.3	2.0	-1.3	-1.1	-1.0	1.4	-0.6
Locomotion velocity, session 2	1.5	1.8	5.4	-0.6	0.8	0.9	1.4	-2.3
Locomotion distance, session 2	0.4	0.5	1.4	-0.8	-0.3	-0.2	1.2	-0.7
Locomotion velocity, session 3	0.2	0.2	0.3	0.6	0.6	0.5	-0.3	0.1
Locomotion distance, session 3	1.1	1.3	2.0	1.4	0.8	0.6	-1.2	1.4
Stereotopy head waving bouts, day 3	0.5	0.6	2.5	-0.3	0.3	0.6	-0.2	-1.6
Stereotopy head waving duration, day 3	0.5	0.6	2.6	-0.3	0.3	0.5	0.3	-1.6
Locomotion velocity, session 7	2.9	3.2	4.4	2.1	2.0	1.9	-1.9	0.6
Locomotion distance, session 7	2.3	3.0	4.5	2.1	1.9	1.5	-1.8	1.0
Stereotopy head waving bouts, day 7	0.8	1.0	2.9	-0.8	-0.1	0.4	1.1	-1.7
Stereotopy head waving duration, day 7	0.4	0.5	2.4	-0.2	0.2	0.5	0.2	-1.5
Locomotion velocity, session 8	0.2	0.2	0.5	0.5	0.7	0.4	0.2	-0.2
Locomotion distance, session 8	0.3	0.4	0.9	0.4	0.8	0.9	0.3	-0.7
Degree of sensitization distance	0.1	0.1	0.2	0.2	0.5	0.4	0.3	-0.1
Degree of sensitization stereotypy	0.6	0.7	2.1	-0.7	-0.5	-0.2	1.4	-0.9
Conditioned locomotion	0.6	0.7	2.1	0.6	0.0	0.1	-1.5	1.0
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.3	0.2
Cocaine response after cond. not corrected	0.1	0.1	0.3	-0.1	-0.1	-0.2	0.5	0.6
Cocaine response before conditioning	0.1	0.1	0.5	0.1	0.1	0.3	0.7	0.2
Saline control response	2.1	2.9	4.7	-1.5	-1.8	-1.5	2.2	1.3
Bone: connectivity density	3.7	6.0	9.0	2.3	3.0	3.0	-1.7	-2.0
Bone: cortical apparent density	0.8	1.3	1.9	-1.3	-0.7	-0.7	1.4	-1.4
Bone: cortical area	2.1	3.4	6.3	2.5	1.5	0.9	-1.5	2.3
Bone: cortical porosity	0.8	0.9	1.5	0.5	1.1	1.1	0.3	-1.2
Bone: cortical porosity	0.9	1.0	2.0	1.0	1.4	1.2	-0.0	-0.7
Bone: cortical thickness	1.1	1.8	5.8	0.1	-1.0	-1.4	0.5	2.4
Bone: cortical thickness	1.4	1.7	2.8	-1.2	-1.4	-1.4	1.7	0.7
Bone: cortical tissue density	1.0	1.5	2.5	-1.4	-0.8	-0.7	1.4	-1.6
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	-0.3	-0.1	-0.1	0.7	0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.4	-0.2	-0.1	0.4	-0.3
Condit. Reinf. active responses	0.3	0.4	1.7	0.2	-0.1	-0.2	0.5	1.3
Condit. Reinf. inactive responses	0.3	0.4	1.7	0.4	-0.1	-0.3	0.3	1.3
Incentive salience index mean	0.7	0.9	1.3	-0.7	-0.9	-0.9	1.1	1.1
Condit. Reinf. lever presses	1.8	2.6	3.8	-1.5	-1.9	-1.8	1.4	1.4
Condit. Reinf. active minus inactive responses	1.6	2.5	3.4	1.7	1.7	1.8	-1.8	-0.2
Condit. Reinf. active-inactive response ratio	0.7	1.1	1.7	0.8	1.0	1.3	-1.2	-0.9
Condit. Reinf. active responses	1.0	1.5	2.4	1.5	0.8	0.7	-1.5	1.3
Condit. Reinf. inactive responses	1.1	1.6	6.0	0.4	-0.7	-1.1	-0.2	2.4
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.5	-0.6	-0.6	0.7	0.3
Condit. Reinf. lever reinforcers received	0.5	0.7	1.3	1.0	0.4	0.4	-1.0	1.1
Conditioned reinforcement - actives	0.1	0.5	0.9	0.9	0.9	0.7	0.7	-0.0
Conditioned reinforcement - inactives	0.7	1.8	3.3	1.4	1.8	1.5	1.0	-0.7
Conditioned locomotion	0.2	0.3	0.8	0.9	0.6	0.1	0.3	0.6
Patch foraging indifference point 0 sec	0.2	0.7	1.1	-0.6	-0.9	-1.0	0.8	0.7
Patch foraging indifference point AUC	1.8	4.2	7.3	-1.5	-2.0	-2.3	2.7	1.5
Delay disc. indifference point, 0s delay	0.9	1.0	3.0	0.3	0.9	1.7	0.1	-1.0
Delay disc. indifference point, 16s delay	0.3	0.4	1.3	-0.6	-0.5	-0.3	1.1	0.2
Delay disc. indifference point, 2s delay	0.4	0.5	1.6	-0.8	-0.2	0.1	0.3	-1.3
Delay disc. indifference point, 24s delay	0.8	1.2	2.2	-0.9	-1.0	-1.2	1.5	0.8
Delay disc. indifference point, 4s delay	0.9	0.9	3.0	-1.0	-0.6	-0.0	1.7	-0.3
Delay disc. indifference point, 8s delay	1.4	2.3	4.3	-2.1	-1.8	-1.3	1.6	-0.2
Indifference point function ln k	1.7	5.1	8.0	2.1	2.3	2.6	-2.8	-1.0
Indifference point function log k	1.7	5.1	8.0	2.1	2.3	2.6	-2.8	-1.0
Patch foraging total patch changes 0 sec	0.2	0.6	0.9	-0.5	-0.9	-1.0	0.7	0.8
Patch foraging total patch changes 12 sec	4.0	5.4	8.7	-2.3	-2.5	-2.5	2.9	0.5
Patch foraging total patch changes 18 sec	0.7	1.7	3.1	-1.5	-1.3	-1.1	1.8	-0.2
Patch foraging total patch changes 24 sec	0.3	1.2	3.0	-0.3	-0.8	-1.0	1.0	1.7
Patch foraging total patch changes 6 sec	3.1	5.2	8.8	-1.9	-2.2	-2.7	3.0	1.2
Patch foraging time to switch 0 sec	0.5	2.0	3.8	-2.0	-1.5	-1.1	1.2	-1.1
Patch foraging water rate 0 sec	0.5	2.0	3.0	1.7	1.7	1.6	-1.3	0.2
Patch foraging water rate 12 sec	0.2	0.9	1.7	1.3	1.1	0.7	-1.0	0.5
Patch foraging water rate 18 sec	0.8	1.8	2.7	1.6	1.6	1.4	-1.2	0.4
Patch foraging water rate 24 sec	0.8	1.1	1.8	1.3	1.1	0.9	-1.1	0.8
Patch foraging water rate 6 sec	0.2	0.3	0.6	0.4	0.5	0.4	-0.7	-0.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.9	0.1	-0.3	-0.2	-0.0	0.9
Distance traveled before self-admin	0.3	0.7	1.2	0.2	0.9	1.1	-0.7	-1.0
Distance traveled after self-admin	1.3	2.3	4.4	0.6	1.6	1.7	-1.1	-2.1
Extensor digitorum longus weight	0.4	1.7	2.8	1.7	1.1	0.7	-1.3	1.6
Bone: elastic displacement	1.3	1.7	6.6	-1.2	-0.3	0.3	0.3	-2.6
Bone: elastic work	1.4	1.8	7.2	-0.5	0.6	1.2	-0.0	-2.7
Bone: endosteal estimation	4.1	10.1	16.0	4.0	4.0	3.4	-2.5	0.3
Bone: endosteal perimeter	3.5	8.6	13.3	3.6	3.6	3.3	-2.4	-0.2
Epididymis fat weight	0.5	2.7	6.1	1.8	1.4	1.6	-2.5	0.0
Delta time in closed arm before/after self-admin	0.6	0.5	1.9	0.2	-0.3	-0.9	-0.1	1.4
Delta time in open arm before/after self-admin	1.2	1.4	4.4	-0.3	0.8	1.3	0.4	-2.1
Diff in mean of infusions in LGA sessions	0.8	1.4	2.6	1.4	1.6	1.2	-0.8	-0.1
Delay discount exponential model param	0.5	0.7	1.7	1.1	0.8	0.3	-1.3	0.3
Extinction: sum of active levers before priming	0.6	1.0	3.4	1.0	0.4	-0.5	-0.1	1.8
Active lever presses in extinction session 6	1.9	1.9	4.0	1.0	1.7	2.0	-0.1	-1.2
Bone: final force	0.7	1.1	2.7	1.4	0.7	0.1	-0.4	1.6
Bone: final moment	0.7	1.1	2.4	1.4	0.8	0.1	-0.6	1.6
Food consumed during 24 hour testing period	0.1	0.2	0.4	0.1	-0.0	-0.6	0.3	0.6
Glucose	0.3	0.5	1.0	1.0	0.6	0.3	-0.6	1.0
Heart weight	0.6	1.0	2.2	0.7	0.0	-1.0	-1.5	1.1
Delay discount hyperbolic model param	0.5	0.6	1.2	1.1	0.7	0.3	-1.1	0.5
Intermittent access intake day 1-15 change	0.4	2.4	3.5	1.8	1.9	1.7	-1.6	-0.4
Intermittent access intake escalation	0.6	3.3	4.5	2.0	2.1	2.1	-1.8	-0.7
Intermittent access intake escalation 2	2.2	3.8	5.6	1.7	2.3	2.4	-1.5	-1.6
Intermitt. access day 1 inactive lever presses	0.0	0.5	1.5	-0.3	0.3	0.6	0.7	-1.2
Intermitt. access day 15 inactive lever presses	0.2	1.3	2.8	1.7	1.6	1.2	-0.3	-0.1
Intermitt. access escalation Index	0.1	0.3	1.0	0.1	0.1	0.6	-1.0	-0.5
Intermittent access day 1 total infusions	0.3	0.8	1.5	1.2	1.2	0.9	0.3	-0.2
Intermittent access day 15 total infusions	1.5	3.7	7.3	2.7	2.3	1.8	-1.4	0.3
Intermittent access terminal intake (last 3 days)	1.7	3.0	5.3	2.3	2.3	1.9	-0.9	-0.5
Intermittent access total infusions	1.4	1.7	3.8	1.9	1.7	1.2	-0.6	0.0
Intermittent access day 1 locomotion	0.2	0.5	1.1	1.1	0.9	0.4	-0.3	0.1
Intermittent access day 15 total locomotion	0.1	0.3	0.9	0.7	0.5	-0.0	0.9	0.2
Intermittent access total locomotion	0.5	0.6	1.2	1.0	1.1	0.6	0.4	-0.4
Intermittent access standard deviation	0.6	3.2	6.0	2.5	2.5	1.7	-1.0	0.2
Left kidney weight	0.2	1.5	5.5	1.0	-0.0	-0.9	0.2	2.4
Right kidney weight	0.4	2.7	8.6	0.2	-1.1	-1.8	0.6	2.9
Cocaine induced anxiety	0.4	1.2	2.4	0.6	1.0	1.6	-1.2	-0.9
Post-drug Anxiety	0.6	0.7	3.0	0.3	-0.1	0.0	-1.7	0.5
Baseline Anxiety	0.9	1.6	3.9	0.0	-1.0	-1.6	-0.7	2.0
Tail length	0.5	2.6	9.6	1.6	0.6	-0.1	-0.6	3.1
Length with tail	0.9	4.1	15.1	2.1	0.7	-0.4	-0.3	3.9
Length without tail	0.6	3.0	6.4	2.4	1.4	0.7	-0.4	2.5
Times rat made contact with spout	0.3	0.3	0.8	-0.2	0.4	0.7	0.2	-0.9
Lifetime Intake	1.1	1.3	3.1	1.8	1.5	1.0	-0.5	0.1
Liver weight, left	0.7	1.2	4.7	0.8	-0.2	-0.6	-0.4	2.2
Liver weight, right	0.7	1.2	2.5	1.6	1.2	0.7	-0.7	1.0
Locomotor activity	0.3	0.5	1.5	-0.4	0.2	0.8	-0.3	-1.2
Locomotor testing distance	0.3	0.7	2.5	-0.7	0.1	0.7	0.4	-1.6
Locomotor testing rearing	0.3	1.0	2.7	0.6	1.1	1.6	-0.1	-0.7
Locomotion in novel chamber	2.4	3.2	5.3	1.3	1.9	2.3	-1.4	-1.9
Locomotion in novel chamber post-restriction	0.2	0.5	1.6	0.3	-0.3	-0.5	0.7	1.3
Fecal boli incidents, locomotor time 1	0.4	1.1	2.9	0.8	1.2	1.7	-0.4	-0.5
Change in fecal boli incidents, locomotor task	1.1	1.2	2.2	-0.9	-1.3	-1.5	0.9	0.7
Time >=10cm from walls, locomotor time 1	2.0	2.4	8.9	1.6	0.6	-0.3	0.0	3.0
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	-0.5	0.4	0.3	-0.1
Total resting periods, locomotor time 1	0.3	0.3	0.8	-0.5	-0.5	0.4	0.9	0.0
Rest time, locomotor task time 1	0.5	0.8	1.6	-0.7	-0.1	1.3	0.7	-1.3
Distance moved, locomotor task time 1	0.5	1.4	4.5	0.6	-0.2	-1.5	-0.0	2.1
Vertical activity count, locomotor time 1	0.1	1.0	2.4	0.3	-0.3	-1.6	-0.3	1.4
Time >=10cm from walls, locomotor time 2	0.1	0.4	1.2	0.6	0.4	0.5	0.3	1.1
Bouts of movement, locomotor time 2	0.9	3.0	5.3	-2.3	-1.6	-0.9	2.1	-1.3
Total resting periods, locomotor time 2	0.7	3.0	5.3	-2.3	-1.5	-0.8	2.3	-1.2
Rest time, locomotor task time 2	0.5	0.9	2.8	-1.0	-0.9	-0.1	1.7	-0.1
Distance moved, locomotor task time 2	0.9	1.2	2.0	1.4	1.0	0.1	-1.1	1.2
Vertical activity count, locomotor time 2	0.1	0.3	0.8	0.6	0.7	0.0	-0.9	0.1
Light reinforcement 1	0.1	0.6	0.8	-0.8	-0.7	-0.8	0.9	-0.5
Light reinforcement 2	1.3	3.0	4.6	-2.1	-1.4	-1.2	1.9	-1.9
Bone: marrow area	4.2	10.3	16.5	4.0	4.1	3.5	-2.6	0.2
Bone: maximum diameter	5.1	10.3	16.7	4.1	3.8	3.5	-2.8	0.3
Bone: maximum force	0.9	1.8	4.0	2.0	1.7	1.2	-0.6	0.6
Bone: maximum moment	1.0	1.9	4.3	2.1	1.7	1.1	-0.8	0.6
Mean time between licks in bursts	0.0	0.2	0.4	-0.2	-0.6	-0.7	-0.4	0.5
Mean num. licks in bursts	1.1	2.9	4.5	2.1	1.9	1.7	-1.8	0.4
Cd content in liver	0.8	0.9	1.3	-1.1	-1.1	-1.1	0.8	-0.5
Co content in liver	0.9	1.1	2.6	-0.7	-1.2	-1.6	-0.7	0.6
Cu content in liver	4.4	5.3	8.6	-2.7	-2.3	-2.2	2.9	-0.7
Fe content in liver	2.1	2.6	3.6	-1.9	-1.9	-1.6	1.7	0.0
K content in liver	0.5	0.5	1.1	-0.9	-0.5	-0.2	1.1	-0.3
Mg content in liver	0.6	0.7	1.3	-1.1	-0.7	-0.4	1.1	-0.5
Mn content in liver	3.4	3.9	6.7	-2.3	-1.7	-1.3	2.6	-1.6
Na content in liver	1.3	1.5	2.7	-1.5	-1.3	-1.0	1.6	-0.1
Rb content in liver	0.3	0.3	0.6	0.8	0.6	0.4	-0.2	0.7
Se content in liver	19.7	23.2	37.5	-6.1	-5.3	-4.9	5.0	-1.3
Sr content in liver	0.6	0.5	1.1	-0.7	-0.3	-0.4	0.9	-1.0
Zn content in liver	2.3	2.7	5.6	-2.4	-1.8	-1.5	1.5	-0.6
Bone: minimum diameter	7.1	13.7	23.9	4.9	4.2	3.6	-3.5	1.3
Time in familiar zone, hab. session 1	0.5	0.6	1.7	0.0	0.4	0.4	-0.9	-1.3
Time in novel zone, hab. session 1	0.5	0.5	1.6	-0.4	-0.5	-0.4	1.3	0.6
Total zone transitions, hab. session 1	0.2	0.3	1.0	-0.4	-0.1	0.1	1.0	-0.4
Total locomotion distance, hab. session 1	1.3	1.9	3.1	-1.7	-1.5	-1.0	1.8	-0.2
Locomotion velocity, hab. session 1	2.2	3.1	4.5	-2.1	-2.1	-1.6	2.1	0.2
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.4	-0.4
Time in novel zone, hab. session 2	0.1	0.1	0.4	0.1	0.1	-0.0	0.6	0.2
Total zone transitions, hab. session 2	0.8	1.1	1.7	-1.0	-1.1	-1.1	1.3	0.2
Total locomotion distance, hab. session 2	1.0	1.3	2.0	-1.2	-1.4	-1.4	1.1	0.4
Locomotion velocity, hab. session 2	1.2	1.7	2.5	-1.4	-1.6	-1.4	1.3	0.3
Novel to familiar place preference ratio	2.2	2.8	5.6	1.0	2.0	2.4	0.3	-1.8
Novelty place preference	2.4	3.0	6.0	1.0	2.1	2.4	0.2	-1.9
Time in novel zone, NPP test	2.6	3.1	6.1	1.1	2.1	2.5	0.2	-1.9
Total zone transitions, NPP test	0.8	1.2	2.0	-0.9	-1.2	-1.4	0.9	1.1
Total locomotion distance, NPP test	2.1	2.9	3.8	-1.9	-2.0	-1.9	1.7	0.6
Locomotion velocity, NPP test	2.0	2.8	3.7	-1.8	-1.9	-1.9	1.7	0.9
Intraocular pressure	0.1	0.2	0.6	-0.4	-0.5	-0.8	0.4	-0.1
Delta distance traveled before/after self-admin	1.0	1.1	1.8	1.2	1.4	1.1	-0.8	-0.6
Delta ambulatory time before/after self-admin	1.0	1.7	2.7	1.5	1.7	1.5	-1.0	-0.6
Parametrial fat weight	0.5	1.2	3.5	-0.3	-1.0	-1.3	-0.0	1.9
Pavlov. Cond. lever latency	0.2	0.3	0.9	0.1	0.1	-0.0	-0.6	-1.0
Pavlov. Cond. magazine entry latency	0.6	0.8	1.6	-0.4	-0.7	-1.0	0.9	1.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.1	0.1	-0.2	0.3	0.5
Pavlov. Cond. index score	0.6	0.8	1.4	-0.4	-0.6	-0.7	1.2	1.2
Pavlov. Cond. latency score	0.6	0.7	1.8	-0.3	-0.6	-0.5	1.1	1.3
Pavlov. Cond. lever contacts	0.6	0.7	1.5	-0.5	-0.7	-0.7	0.9	1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.5	-0.0	0.1	0.5	-0.1	-0.7
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.6	0.2	-0.2	0.1	0.0	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.2	-0.5	-0.6	-0.7	1.1	1.0
Pavlov. Cond. response bias	0.2	0.2	0.4	-0.3	-0.3	-0.6	0.5	0.6
Pavlov. Cond. lever latency	0.9	1.3	2.5	0.7	1.1	1.6	-1.0	-1.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.7	-0.1	-0.2	-0.7	-0.1	0.8
Pavlov. Cond. change in total contacts	0.3	0.8	2.2	-0.3	-0.7	-1.0	0.2	1.5
Pavlov. Cond. index score	0.7	1.0	2.6	-0.3	-0.7	-1.3	0.6	1.6
Pavlov. Cond. latency score	0.5	0.8	2.4	-0.1	-0.5	-1.1	0.6	1.5
Pavlov. Cond. lever contacts	1.1	1.6	3.0	-0.7	-1.2	-1.7	0.9	1.5
Pavlov. Cond. magazine entry number	1.2	1.6	3.2	0.8	1.2	1.6	-0.5	-1.8
Pavlov. Cond. intertrial magazine entries	0.6	1.4	2.4	1.0	1.1	1.5	-1.3	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.8	2.1	-0.3	-0.6	-1.1	0.6	1.5
Pavlov. Cond. response bias	1.0	1.4	2.6	-0.7	-1.1	-1.6	0.7	1.5
Time in closed arm before self-admin	0.6	1.0	2.9	-0.1	0.7	1.2	0.0	-1.7
Time in closed arm after self-admin	0.1	0.2	0.3	-0.5	-0.5	-0.4	-0.2	0.2
Time in open arm before self-admin	0.2	0.2	0.6	-0.2	-0.5	-0.3	-0.8	0.1
Time in open arm after self-admin	0.4	0.5	1.6	-0.5	0.0	0.4	0.6	-1.3
Bone: periosteal estimation	3.3	8.0	14.8	3.8	3.4	2.7	-2.2	1.2
Bone: periosteal perimeter	3.0	5.9	10.1	3.2	2.8	2.5	-2.2	0.7
Bone: post-yield work	1.3	2.3	4.9	2.2	1.9	1.3	-1.0	0.6
Progressive ratio test 1 active lever presses	0.2	0.4	0.8	0.9	0.8	0.5	0.3	-0.2
Progressive ratio test 1 breakpoint	0.1	0.2	0.6	0.8	0.6	0.3	0.4	-0.1
Progressive ratio test 1 inactive lever presses	0.5	1.3	2.2	1.2	1.5	1.4	0.5	-0.7
Progressive ratio test 2 active lever presses	1.8	2.6	4.6	2.1	2.1	2.0	-0.1	-0.4
Progressive ratio test 2 breakpoint	2.1	2.7	4.8	2.1	2.2	2.0	-0.1	-0.4
Progressive ratio test 2 inactive lever presses	0.5	1.6	2.6	1.1	1.6	1.6	0.6	-1.2
Incentive Sensitization - Responses	1.1	3.1	5.8	2.0	2.4	2.2	-0.4	-0.8
Incentive Sensitization - Breakpoint	1.3	3.0	5.6	2.1	2.4	2.1	-0.3	-0.6
Sum of active levers in priming session hrs 5-6	0.4	0.3	0.7	-0.8	-0.4	-0.7	0.0	-0.6
Progressive ratio	0.2	0.7	1.9	-0.1	-0.8	-0.6	-0.8	1.4
Food seeking constrained by brief footshock	0.7	0.9	3.2	0.9	0.2	-0.2	0.7	1.8
Seeking ratio, punishment vs. effort	0.2	0.5	2.0	0.2	0.4	-0.1	1.4	0.2
Retroperitoneal fat weight	0.1	0.6	1.5	0.5	-0.2	-0.7	-0.9	1.2
Reaction time number correct	0.6	2.1	4.0	1.2	1.6	2.0	-1.3	-1.0
Reaction time mean minus median	0.1	0.9	2.1	1.1	0.9	0.4	-1.4	0.4
Reaction time mean minus median AUC	0.1	0.6	2.3	0.5	0.5	0.2	-1.5	-0.0
Reaction time num false alarms	0.7	1.1	4.8	0.7	-0.2	-0.5	0.1	2.2
Reaction time num false alarms AUC	0.5	1.2	5.3	0.7	-0.1	-0.6	0.1	2.3
Reaction time trials correct on left	0.6	2.1	4.0	1.2	1.6	2.0	-1.3	-1.0
Reaction time trials on left	0.6	2.0	3.9	1.2	1.5	2.0	-1.3	-0.9
Reaction time mean	0.2	0.5	0.9	-0.2	-0.5	-1.0	-0.3	1.0
Reaction time mean AUC	0.3	0.7	1.6	-0.5	-0.8	-1.3	-0.1	0.9
Median of all reaction times	0.4	0.6	1.2	-0.6	-0.8	-1.1	0.1	0.8
Reaction time omissions	0.8	1.2	3.4	1.1	0.7	0.5	-1.8	0.9
Reaction time false alarm rate	1.4	2.0	6.4	0.1	-0.9	-1.5	0.6	2.5
Reaction time premature initiation rate	1.0	1.5	5.9	0.3	-0.6	-1.0	0.5	2.4
Reaction time premature initiations	0.3	1.1	4.0	1.1	0.3	0.0	-0.2	2.0
Std. dev. reaction times	0.3	0.9	2.4	0.7	0.2	-0.3	-1.5	1.2
Reaction time trials completed	0.6	2.0	3.9	1.2	1.5	2.0	-1.3	-0.9
Reaction time trials AUC	0.5	1.8	3.5	1.1	1.4	1.9	-1.1	-0.9
Run reversals in cocaine runway, females	0.6	0.7	1.0	-1.0	-0.4	-0.6	1.0	-1.0
Run reversals in cocaine runway, males	2.5	2.8	4.8	-1.1	-1.8	-2.2	1.7	1.4
Latency to leave start box in cocaine runway	1.9	2.6	6.2	1.5	1.4	1.5	-2.5	-0.3
Latency to leave start box in cocaine runway, F	2.3	2.9	4.4	1.6	1.7	2.0	-2.1	-0.7
Latency to leave start box in cocaine runway, M	0.5	0.5	2.3	0.3	0.2	0.3	-1.5	0.1
Std. dev. time between licks in bursts	1.0	1.9	3.6	-1.5	-1.8	-1.9	0.5	0.3
Total sessions with >9 infusions	0.1	0.1	0.2	-0.2	-0.3	-0.4	0.4	-0.1
Short access day 1 total inactive lever presses	1.2	2.5	6.8	0.7	1.5	1.6	-0.5	-2.6
Short access day 10 total inactive lever presses	0.0	0.0	0.2	-0.2	0.0	0.4	0.1	-0.1
Short access day 1 total infusions	0.2	0.3	1.0	-0.4	-0.4	-0.4	1.0	-0.5
Short access day 10 total infusions	0.2	0.3	0.7	-0.2	-0.5	-0.8	0.8	0.3
Short access total infusions	0.2	0.2	0.5	0.7	0.7	0.4	0.2	-0.3
Short access day 1 locomotion	0.3	0.5	1.8	-0.5	0.1	0.2	0.6	-1.4
Short access day 10 total locomotion	0.1	0.5	1.1	-0.7	-0.4	-0.6	1.0	-0.6
Short access total locomotion	0.4	0.6	1.5	-0.8	-0.2	-0.2	0.9	-1.2
One hour access (0.3 mA shock)	4.1	4.9	8.8	3.0	3.0	2.6	-0.4	-0.2
Compulsive drug intake	0.8	1.1	2.0	1.3	1.2	1.4	-0.7	0.1
One hour access (shock baseline)	0.3	0.8	2.2	1.5	1.1	0.5	-0.2	0.7
Social response proportion	2.2	2.7	4.6	1.0	1.7	2.1	-1.5	-1.8
Social responses	0.6	0.8	1.1	0.9	1.0	0.9	-0.8	-0.6
Social time	0.3	0.5	0.8	-0.6	-0.7	-0.9	0.6	0.7
Soleus weight	1.3	4.0	5.7	2.4	2.3	1.8	-2.4	0.1
Bone: stiffness	1.6	2.8	6.1	2.5	1.8	1.2	-0.8	1.6
Tibialis anterior weight	0.7	2.3	3.2	1.8	1.5	1.6	-1.5	1.2
Time to tail flick, vehicle, before self-admin	1.3	1.6	3.8	-1.5	-0.8	-0.4	1.0	-2.0
Time to tail flick, vehicle, after self-admin	0.2	0.5	1.6	0.6	0.4	0.4	0.2	1.3
Time to tail flick, test, before self-admin	0.8	0.9	1.8	1.3	1.4	0.9	-0.5	0.1
Time to tail flick, test, after self-admin	0.4	0.5	1.4	-0.9	-0.1	0.3	0.1	-1.2
Delta time to tail flick, vehicle, before/after SA	2.0	2.2	5.8	1.7	1.1	0.9	-0.4	2.4
Delta time to tail flick, test, before/after SA	0.5	0.7	1.5	-1.2	-0.8	-0.2	0.6	-0.9
Tibia length	0.2	0.4	1.6	0.2	-0.3	-0.7	0.2	1.2
Ambulatory time before self-admin	0.2	0.7	1.8	-0.1	0.6	0.9	-0.8	-1.3
Ambulatory time after self-admin	2.6	4.2	7.0	1.0	2.3	2.5	-1.2	-2.7
Bone: tissue strength	0.4	0.4	0.7	0.9	0.6	0.1	-0.8	0.7
Total heroin consumption	0.2	0.2	0.7	0.4	0.2	-0.2	0.4	0.9
Bone: trabecular number	1.9	3.6	5.8	2.1	2.4	2.3	-1.1	-1.3
Bone: trabecular spacing	0.9	1.4	2.1	-0.9	-1.3	-1.5	0.2	1.4
Bone: trabecular thickness	1.9	2.6	3.9	2.0	1.9	1.9	-1.2	-0.2
Bone: trabecular tissue density	0.4	0.7	1.1	1.0	1.1	1.0	-0.4	-0.3
Water consumed over 24 hours	0.4	0.7	1.5	0.3	1.0	1.2	0.6	-0.9
Number of responses in last shaping day	0.2	0.2	0.9	-0.3	-0.3	-0.1	0.2	-0.9