Hub : Genes

Pcsk4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Pcsk4	0.02	0.02	4.2e-03	0.01	0.01	0	0.01	1.9e-02	1.3e-02	1.0e-01	4.8e-02
2	Liver	mRNA stability	Pcsk4	0.07	0.05	2.1e-08	0.04	0.06	0.05	0.06	8.6e-06	3.8e-07	1.6e-06	8.2e-07
3	BLA	gene expression	Pcsk4	0.06	0.04	5.8e-04	0.06	0.07	0.07	0.08	2.4e-04	1.5e-04	2.0e-04	7.5e-05
4	Adipose	gene expression	Pcsk4	0.03	0.03	7.2e-04	0.02	0.02	0.01	0.02	2.0e-03	4.2e-03	1.0e-02	4.1e-03
5	pVTA	gene expression	Pcsk4	0.06	0.05	3.8e-06	0.07	0.06	0.06	0.06	3.1e-06	9.3e-06	7.6e-06	7.3e-06
6	NAcc	gene expression	Pcsk4	0.09	0.05	2.2e-16	0.1	0.1	0.1	0.1	1.9e-14	3.4e-15	9.6e-15	9.8e-15
7	Brain	mRNA stability	Pcsk4	0.05	0.04	1.1e-04	0.04	0.04	0.04	0.03	1.6e-04	3.0e-04	1.1e-04	4.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	0.5	0.8	2.5	-0.0	-0.1	0.5	0.7	0.7	1.6	-1.4
Area under the delay curve	2.1	2.4	2.9	-1.6	-1.7	1.7	1.7	1.7	1.3	-1.2
BMI with tail	5.9	20.2	24.1	-4.9	-4.9	4.8	4.6	4.6	3.6	-3.9
BMI without tail	1.6	4.9	7.1	-2.7	-2.6	2.4	2.3	2.2	1.5	-1.6
Body weight	0.8	3.7	4.4	-2.1	-2.1	2.0	2.0	1.9	1.6	-1.7
Weight adjusted by age	0.2	0.3	0.6	-0.8	-0.8	0.4	0.3	0.4	-0.0	-0.3
Bone surface	0.4	0.7	2.6	0.8	0.7	0.0	0.3	0.3	1.6	-1.1
Bone volume	0.4	0.7	2.9	0.6	0.5	0.1	0.3	0.3	1.7	-1.2
Breakpoint value in progressive ratio session	4.0	4.8	6.2	2.1	2.1	-2.2	-2.3	-2.1	-2.0	2.5
Number of licking bursts	0.1	0.1	0.5	-0.3	-0.3	-0.1	-0.2	-0.2	-0.7	0.3
Context. condit. distance diff. score	0.3	0.3	0.4	-0.7	-0.7	0.7	0.6	0.6	0.3	-0.1
Locomotion velocity, session 1	0.3	0.3	0.8	0.9	0.8	-0.5	-0.4	-0.4	0.2	-0.1
Locomotion distance, session 1	0.4	0.5	1.3	0.7	0.6	0.0	0.1	0.1	1.1	-1.0
Locomotion velocity, session 2	2.5	2.9	6.0	2.4	2.4	-1.7	-1.5	-1.5	-0.5	0.8
Locomotion distance, session 2	1.0	1.4	3.4	1.9	1.8	-1.1	-1.0	-1.0	0.3	-0.3
Locomotion velocity, session 3	6.1	7.0	7.5	2.7	2.7	-2.7	-2.6	-2.6	-2.5	2.6
Locomotion distance, session 3	0.0	0.0	0.1	-0.1	-0.0	-0.0	-0.0	-0.0	-0.3	0.3
Stereotopy head waving bouts, day 3	4.1	4.8	7.1	2.7	2.6	-2.2	-2.2	-2.2	-1.6	1.6
Stereotopy head waving duration, day 3	5.4	6.4	8.4	2.9	2.9	-2.6	-2.5	-2.5	-2.0	2.1
Locomotion velocity, session 7	0.6	0.6	1.3	0.6	0.6	-0.8	-0.8	-0.8	-0.7	1.1
Locomotion distance, session 7	0.1	0.2	0.4	-0.7	-0.6	0.2	0.1	0.1	-0.3	0.4
Stereotopy head waving bouts, day 7	0.2	0.2	0.6	0.1	0.1	0.3	0.4	0.4	0.7	-0.7
Stereotopy head waving duration, day 7	0.2	0.2	0.6	0.8	0.7	-0.3	-0.2	-0.2	0.4	-0.3
Locomotion velocity, session 8	0.3	0.4	1.1	1.0	1.0	-0.5	-0.3	-0.3	0.5	-0.3
Locomotion distance, session 8	0.1	0.1	0.3	0.6	0.6	-0.2	-0.2	-0.2	0.2	-0.1
Degree of sensitization distance	0.4	0.4	0.6	-0.7	-0.8	0.7	0.7	0.7	0.6	-0.5
Degree of sensitization stereotypy	2.1	2.2	2.6	-1.3	-1.3	1.5	1.6	1.6	1.6	-1.6
Conditioned locomotion	0.8	0.9	1.9	-1.4	-1.4	1.0	0.9	0.9	0.2	-0.4
Cocaine response after cond. corrected	3.8	4.6	7.9	-2.8	-2.8	2.3	2.1	2.1	1.0	-1.0
Cocaine response after cond. not corrected	4.0	4.7	8.2	-2.9	-2.8	2.3	2.2	2.2	1.0	-1.0
Cocaine response before conditioning	0.5	0.5	0.7	0.8	0.8	-0.7	-0.7	-0.7	-0.5	0.8
Saline control response	0.1	0.1	0.2	-0.5	-0.4	0.3	0.2	0.2	-0.0	0.3
Bone: connectivity density	0.7	1.0	2.3	-0.4	-0.4	0.8	1.0	1.0	1.5	-1.4
Bone: cortical apparent density	0.8	1.2	1.3	-1.1	-1.1	1.1	1.1	1.1	1.0	-0.9
Bone: cortical area	0.6	0.9	1.7	-0.7	-0.7	0.9	1.0	1.0	1.3	-1.1
Bone: cortical porosity	0.1	0.1	0.2	0.4	0.4	-0.3	-0.2	-0.2	0.3	-0.3
Bone: cortical porosity	0.2	0.2	0.7	0.2	0.2	0.1	0.2	0.2	0.8	-0.8
Bone: cortical thickness	1.2	2.0	2.7	-1.3	-1.3	1.4	1.5	1.5	1.6	-1.5
Bone: cortical thickness	0.2	0.2	0.7	-0.1	-0.1	-0.3	-0.4	-0.4	-0.8	0.7
Bone: cortical tissue density	0.6	0.8	0.8	-0.9	-0.9	0.9	0.9	0.9	0.8	-0.8
Condit. Reinf. active minus inactive responses	4.1	4.6	5.5	2.3	2.3	-2.1	-2.1	-2.1	-1.9	2.1
Condit. Reinf. active-inactive response ratio	2.6	2.8	3.7	1.5	1.5	-1.6	-1.6	-1.6	-1.8	1.9
Condit. Reinf. active responses	2.9	3.6	5.8	2.4	2.4	-1.9	-1.9	-1.9	-1.2	1.3
Condit. Reinf. inactive responses	0.5	0.6	1.5	1.2	1.2	-0.7	-0.6	-0.6	0.3	-0.2
Incentive salience index mean	1.8	2.2	3.6	1.9	1.9	-1.5	-1.4	-1.4	-0.9	1.1
Condit. Reinf. lever presses	0.3	0.5	1.3	0.4	0.4	0.2	0.3	0.3	1.2	-1.1
Condit. Reinf. active minus inactive responses	2.6	3.4	4.3	1.5	1.5	-1.9	-1.9	-1.9	-2.1	1.9
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.0	0.1	0.1	-0.5	-0.6	-0.6	-1.0	0.4
Condit. Reinf. active responses	2.4	3.3	3.8	1.6	1.6	-1.9	-1.9	-1.9	-1.8	1.9
Condit. Reinf. inactive responses	1.2	1.5	2.7	1.2	1.1	-1.2	-1.2	-1.2	-1.0	1.6
Condit. Reinf. lever presses	2.2	3.1	4.2	1.5	1.5	-1.7	-1.8	-1.8	-1.9	2.1
Condit. Reinf. lever reinforcers received	2.0	2.7	3.7	1.3	1.3	-1.7	-1.7	-1.7	-1.8	1.9
Conditioned reinforcement - actives	1.1	1.9	2.7	1.0	1.1	-1.5	-1.6	-1.5	-1.6	1.1
Conditioned reinforcement - inactives	0.0	0.0	0.1	-0.2	-0.2	-0.0	-0.1	0.0	-0.3	-0.0
Conditioned locomotion	7.1	9.2	11.0	3.2	3.2	-3.3	-3.3	-3.1	-2.5	2.6
Patch foraging indifference point 0 sec	0.2	0.3	0.5	-0.5	-0.5	0.5	0.6	0.5	0.7	-0.6
Patch foraging indifference point AUC	0.9	1.2	1.5	1.0	1.1	-1.2	-1.2	-1.2	-1.1	0.9
Delay disc. indifference point, 0s delay	9.6	10.6	14.8	-2.7	-2.7	3.2	3.2	3.3	3.6	-3.8
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	-0.4	-0.4	0.5	0.6	0.5	0.4	-0.1
Delay disc. indifference point, 2s delay	6.5	7.2	8.0	-2.6	-2.6	2.8	2.8	2.8	2.7	-2.4
Delay disc. indifference point, 24s delay	0.5	0.5	0.9	-0.9	-0.9	0.7	0.8	0.7	0.4	-0.3
Delay disc. indifference point, 4s delay	1.5	1.6	2.2	-1.1	-1.1	1.4	1.5	1.4	1.2	-1.0
Delay disc. indifference point, 8s delay	1.0	1.2	1.9	-1.4	-1.4	1.1	1.1	1.1	0.6	-0.7
Indifference point function ln k	0.1	0.2	0.3	-0.5	-0.5	0.4	0.4	0.4	0.1	0.0
Indifference point function log k	0.1	0.2	0.3	-0.5	-0.5	0.4	0.4	0.4	0.1	0.0
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.4	-0.4	0.5	0.5	0.5	0.6	-0.5
Patch foraging total patch changes 12 sec	0.2	0.3	0.6	-0.8	-0.8	0.6	0.5	0.5	0.3	-0.5
Patch foraging total patch changes 18 sec	0.7	1.1	1.3	1.1	1.1	-1.1	-1.0	-1.1	-0.8	0.9
Patch foraging total patch changes 24 sec	0.0	0.1	0.1	0.3	0.3	-0.3	-0.2	-0.3	-0.0	0.3
Patch foraging total patch changes 6 sec	0.1	0.2	0.3	0.6	0.6	-0.5	-0.4	-0.5	-0.1	-0.1
Patch foraging time to switch 0 sec	1.5	3.1	5.2	-1.0	-1.1	1.7	1.8	1.7	2.3	-2.2
Patch foraging water rate 0 sec	0.2	0.5	1.6	-0.3	-0.3	-0.4	-0.5	-0.5	-1.3	1.1
Patch foraging water rate 12 sec	0.4	0.9	2.3	-1.5	-1.5	0.9	0.8	0.8	-0.2	-0.0
Patch foraging water rate 18 sec	1.0	1.5	4.4	-0.2	-0.2	-0.7	-0.9	-0.9	-2.1	1.9
Patch foraging water rate 24 sec	0.4	0.6	1.5	-1.1	-1.0	0.2	-0.0	0.0	-1.2	0.8
Patch foraging water rate 6 sec	0.9	1.4	3.2	0.3	0.3	-1.0	-1.1	-1.1	-1.7	1.8
Seeking ratio, delayed vs. immediate footshock	3.7	4.5	5.3	2.3	2.3	-2.2	-2.1	-2.1	-1.6	2.3
Distance traveled before self-admin	0.2	0.2	0.4	-0.4	-0.4	0.4	0.4	0.6	0.6	-0.4
Distance traveled after self-admin	0.0	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.1	0.0	0.2
Extensor digitorum longus weight	3.7	14.4	20.0	-4.5	-4.4	4.1	3.9	3.9	2.6	-2.7
Bone: elastic displacement	0.1	0.1	0.2	0.4	0.4	-0.5	-0.4	-0.4	-0.3	0.2
Bone: elastic work	0.3	0.4	0.5	-0.6	-0.7	0.6	0.7	0.7	0.6	-0.4
Bone: endosteal estimation	0.2	0.4	0.5	-0.6	-0.6	0.7	0.7	0.7	0.6	-0.5
Bone: endosteal perimeter	0.2	0.3	0.7	0.8	0.8	-0.6	-0.5	-0.5	-0.2	0.4
Epididymis fat weight	0.1	0.2	0.7	-0.2	-0.2	-0.1	-0.3	-0.1	-0.8	0.8
Delta time in closed arm before/after self-admin	0.5	0.4	1.1	-1.1	-1.0	0.3	0.1	0.2	-0.7	0.5
Delta time in open arm before/after self-admin	0.7	0.6	0.9	-0.8	-0.8	0.9	0.9	0.9	0.7	-0.7
Diff in mean of infusions in LGA sessions	1.5	1.8	2.3	1.5	1.5	-1.2	-1.3	-1.2	-1.1	1.5
Delay discount exponential model param	1.7	1.9	2.3	1.5	1.5	-1.5	-1.5	-1.5	-1.2	0.9
Extinction: sum of active levers before priming	1.2	1.4	1.8	0.9	0.9	-1.2	-1.3	-1.2	-1.2	1.3
Active lever presses in extinction session 6	2.1	2.1	2.7	1.6	1.6	-1.6	-1.6	-1.5	-1.0	1.1
Bone: final force	1.5	2.4	3.1	-1.4	-1.5	1.5	1.6	1.6	1.8	-1.4
Bone: final moment	1.2	2.0	2.5	-1.3	-1.3	1.4	1.5	1.5	1.6	-1.3
Food consumed during 24 hour testing period	0.4	0.6	0.9	-1.0	-0.9	0.8	0.8	0.8	0.5	-0.3
Glucose	2.4	3.8	4.8	-2.2	-2.2	2.0	2.0	2.0	1.5	-1.7
Heart weight	0.9	1.4	2.6	0.7	0.8	-1.1	-1.2	-1.1	-1.6	1.6
Delay discount hyperbolic model param	3.1	3.4	4.0	2.0	2.0	-2.0	-2.0	-2.0	-1.7	1.4
Intermittent access intake day 1-15 change	3.6	7.4	8.4	2.5	2.5	-2.9	-2.9	-2.9	-2.8	2.6
Intermittent access intake escalation	3.2	6.5	7.4	2.3	2.3	-2.7	-2.7	-2.7	-2.6	2.4
Intermittent access intake escalation 2	5.0	5.7	6.5	2.2	2.2	-2.5	-2.5	-2.5	-2.4	2.4
Intermitt. access day 1 inactive lever presses	0.2	0.6	1.5	0.0	0.1	-0.7	-0.8	-0.7	-1.2	1.0
Intermitt. access day 15 inactive lever presses	0.2	0.4	0.5	0.7	0.7	-0.6	-0.6	-0.6	-0.5	0.3
Intermitt. access escalation Index	1.0	1.4	2.5	-0.8	-0.8	1.1	1.2	1.1	1.5	-1.6
Intermittent access day 1 total infusions	0.2	0.3	0.7	0.2	0.2	-0.6	-0.6	-0.4	-0.9	0.6
Intermittent access day 15 total infusions	2.8	4.1	5.0	1.8	1.8	-2.2	-2.2	-2.0	-2.1	1.9
Intermittent access terminal intake (last 3 days)	2.0	2.6	3.5	1.5	1.5	-1.8	-1.9	-1.6	-1.6	1.4
Intermittent access total infusions	1.1	1.3	1.8	1.0	1.0	-1.3	-1.4	-1.1	-1.3	0.9
Intermittent access day 1 locomotion	1.9	2.4	3.6	1.2	1.2	-1.6	-1.7	-1.5	-1.9	1.8
Intermittent access day 15 total locomotion	3.2	5.8	7.0	2.2	2.3	-2.6	-2.6	-2.5	-2.5	2.1
Intermittent access total locomotion	2.7	3.3	4.0	1.6	1.6	-1.9	-2.0	-1.8	-1.9	1.7
Intermittent access standard deviation	3.6	7.5	8.9	2.8	2.8	-3.0	-3.0	-2.8	-2.5	2.3
Left kidney weight	0.0	0.2	0.7	-0.3	-0.3	-0.1	-0.2	-0.2	-0.7	0.9
Right kidney weight	0.6	2.9	5.2	1.1	1.2	-1.6	-1.7	-1.6	-2.0	2.3
Cocaine induced anxiety	0.7	1.0	2.1	1.5	1.4	-1.0	-0.9	-1.0	-0.1	0.4
Post-drug Anxiety	0.8	0.9	2.0	1.4	1.4	-0.8	-0.7	-0.7	-0.0	0.6
Baseline Anxiety	0.1	0.2	0.7	0.2	0.2	-0.3	-0.3	-0.1	-0.4	0.8
Tail length	3.5	13.7	14.9	3.6	3.6	-3.9	-3.8	-3.8	-3.4	3.7
Length with tail	1.9	8.4	9.1	2.9	2.9	-3.0	-3.0	-3.0	-2.7	2.9
Length without tail	0.0	0.0	0.0	-0.2	-0.2	0.1	0.1	0.1	-0.0	0.0
Times rat made contact with spout	0.1	0.1	0.3	-0.6	-0.6	0.3	0.2	0.2	-0.2	0.2
Lifetime Intake	0.6	0.7	1.2	0.7	0.7	-1.0	-1.1	-0.8	-1.0	0.7
Liver weight, left	0.8	1.4	1.7	-1.3	-1.3	1.3	1.2	1.3	0.8	-0.9
Liver weight, right	0.4	0.8	1.4	-1.2	-1.2	0.9	0.8	0.9	0.4	-0.2
Locomotor activity	2.5	3.8	5.5	2.3	2.3	-2.2	-2.1	-2.0	-0.9	1.5
Locomotor testing distance	1.4	2.5	3.6	1.9	1.9	-1.7	-1.6	-1.6	-0.7	1.3
Locomotor testing rearing	0.1	0.2	0.6	0.1	0.1	-0.3	-0.4	-0.3	-0.6	0.8
Locomotion in novel chamber	1.1	1.4	1.8	1.0	1.1	-1.3	-1.3	-1.3	-1.2	1.0
Locomotion in novel chamber post-restriction	1.4	2.3	4.4	1.3	1.3	-1.5	-1.5	-1.4	-1.5	2.1
Fecal boli incidents, locomotor time 1	1.1	1.6	2.1	-1.5	-1.4	1.3	1.2	1.3	1.1	-1.1
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	0.5	0.4	-0.5	-0.5	-0.4	-0.1	0.3
Time >=10cm from walls, locomotor time 1	0.8	0.8	2.0	-0.5	-0.6	0.6	0.7	0.6	1.3	-1.4
Bouts of movement, locomotor time 1	0.3	0.4	0.5	0.5	0.5	-0.7	-0.7	-0.7	-0.7	0.6
Total resting periods, locomotor time 1	0.4	0.5	0.5	0.7	0.7	-0.7	-0.7	-0.7	-0.7	0.7
Rest time, locomotor task time 1	0.2	0.2	0.4	0.6	0.6	-0.4	-0.5	-0.4	-0.2	0.3
Distance moved, locomotor task time 1	0.9	1.3	2.6	-0.8	-0.8	0.9	1.1	1.0	1.5	-1.6
Vertical activity count, locomotor time 1	0.1	0.2	0.4	-0.7	-0.7	0.3	0.3	0.3	0.1	-0.2
Time >=10cm from walls, locomotor time 2	0.7	1.1	2.0	-1.4	-1.4	1.0	1.0	0.9	0.7	-0.7
Bouts of movement, locomotor time 2	0.2	0.2	0.6	0.8	0.8	-0.4	-0.3	-0.3	0.2	-0.4
Total resting periods, locomotor time 2	0.1	0.2	0.6	0.8	0.7	-0.3	-0.2	-0.3	0.3	-0.5
Rest time, locomotor task time 2	0.4	0.5	1.0	1.0	1.0	-0.8	-0.6	-0.7	-0.3	0.4
Distance moved, locomotor task time 2	0.5	0.6	0.9	-0.9	-0.9	0.8	0.7	0.7	0.5	-0.8
Vertical activity count, locomotor time 2	0.3	0.4	1.0	-1.0	-1.0	0.6	0.4	0.5	0.0	-0.3
Light reinforcement 1	3.6	8.9	12.4	3.5	3.5	-3.1	-2.9	-3.1	-2.1	2.5
Light reinforcement 2	1.5	2.3	3.4	1.8	1.8	-1.6	-1.5	-1.5	-1.0	1.2
Bone: marrow area	0.2	0.4	0.5	-0.6	-0.6	0.7	0.7	0.7	0.6	-0.5
Bone: maximum diameter	0.6	1.1	1.9	1.4	1.3	-1.1	-1.0	-1.0	-0.4	0.7
Bone: maximum force	1.3	2.4	2.7	-1.5	-1.5	1.6	1.6	1.6	1.6	-1.3
Bone: maximum moment	1.1	2.0	2.3	-1.4	-1.4	1.4	1.5	1.5	1.4	-1.2
Mean time between licks in bursts	2.5	6.1	6.8	2.5	2.6	-2.6	-2.6	-2.6	-2.3	2.1
Mean num. licks in bursts	0.0	0.1	0.2	-0.1	-0.1	0.3	0.3	0.3	0.4	-0.1
Cd content in liver	0.1	0.2	0.2	0.5	0.5	-0.4	-0.4	-0.4	-0.2	0.1
Co content in liver	1.7	2.0	2.3	1.3	1.4	-1.5	-1.5	-1.5	-1.4	1.3
Cu content in liver	0.1	0.2	0.3	0.6	0.5	-0.3	-0.2	-0.2	0.4	-0.4
Fe content in liver	0.2	0.2	0.3	0.4	0.4	-0.5	-0.5	-0.5	-0.6	0.2
K content in liver	0.1	0.1	0.3	0.3	0.2	0.0	0.1	0.1	0.6	-0.5
Mg content in liver	0.2	0.2	0.4	0.6	0.6	-0.5	-0.5	-0.5	-0.1	0.1
Mn content in liver	0.9	0.9	2.2	1.5	1.4	-1.0	-0.8	-0.8	0.1	0.1
Na content in liver	1.4	1.5	2.9	-0.8	-0.8	1.1	1.2	1.2	1.6	-1.7
Rb content in liver	0.1	0.1	0.6	0.3	0.2	0.1	0.2	0.2	0.8	-0.5
Se content in liver	0.2	0.2	0.3	0.5	0.5	-0.5	-0.5	-0.5	-0.5	0.3
Sr content in liver	0.0	0.0	0.1	-0.2	-0.1	0.0	-0.0	-0.0	-0.2	0.2
Zn content in liver	5.0	5.6	7.9	1.9	1.9	-2.3	-2.4	-2.4	-2.8	2.6
Bone: minimum diameter	0.0	0.1	0.2	-0.1	-0.1	0.2	0.3	0.3	0.5	-0.2
Time in familiar zone, hab. session 1	2.6	2.5	3.7	1.4	1.4	-1.5	-1.5	-1.5	-1.7	1.9
Time in novel zone, hab. session 1	1.5	1.5	2.3	-0.9	-1.0	1.1	1.2	1.2	1.5	-1.5
Total zone transitions, hab. session 1	0.5	0.7	1.8	1.3	1.3	-0.8	-0.7	-0.7	0.2	-0.2
Total locomotion distance, hab. session 1	0.6	0.9	2.3	1.5	1.5	-0.8	-0.7	-0.7	0.5	-0.2
Locomotion velocity, hab. session 1	1.0	1.4	3.2	1.8	1.7	-1.1	-1.0	-1.0	0.1	0.0
Time in familiar zone, hab. session 2	7.3	7.7	9.1	2.5	2.6	-2.8	-2.8	-2.8	-2.9	3.0
Time in novel zone, hab. session 2	5.6	5.7	6.5	-2.2	-2.2	2.4	2.4	2.4	2.6	-2.5
Total zone transitions, hab. session 2	1.1	1.4	4.0	0.0	-0.1	0.8	0.9	0.9	1.9	-2.0
Total locomotion distance, hab. session 2	0.7	0.9	2.2	1.5	1.4	-0.8	-0.7	-0.7	0.2	-0.1
Locomotion velocity, hab. session 2	0.7	0.9	2.3	1.5	1.5	-0.7	-0.6	-0.6	0.5	-0.4
Novel to familiar place preference ratio	5.1	5.5	7.1	-2.0	-2.0	2.3	2.4	2.4	2.7	-2.7
Novelty place preference	3.2	3.5	4.8	-1.5	-1.6	1.8	1.9	1.9	2.2	-2.2
Time in novel zone, NPP test	3.6	3.8	4.9	-1.7	-1.7	1.9	2.0	2.0	2.2	-2.2
Total zone transitions, NPP test	0.4	0.5	1.8	0.3	0.2	0.3	0.4	0.4	1.2	-1.3
Total locomotion distance, NPP test	0.3	0.5	1.4	0.2	0.2	0.4	0.5	0.5	1.2	-1.1
Locomotion velocity, NPP test	0.2	0.3	0.9	0.5	0.5	0.1	0.2	0.2	0.9	-0.9
Intraocular pressure	0.3	0.4	1.3	-0.3	-0.2	-0.3	-0.4	-0.4	-1.1	1.0
Delta distance traveled before/after self-admin	0.5	0.5	0.8	0.6	0.6	-0.7	-0.6	-0.9	-0.7	0.9
Delta ambulatory time before/after self-admin	0.3	0.4	0.7	0.7	0.7	-0.6	-0.6	-0.8	-0.5	0.6
Parametrial fat weight	0.0	0.0	0.1	0.1	0.1	0.0	0.0	0.1	0.3	-0.3
Pavlov. Cond. lever latency	0.2	0.3	0.9	-0.3	-0.2	-0.2	-0.3	-0.3	-0.9	0.8
Pavlov. Cond. magazine entry latency	3.0	3.8	4.6	2.1	2.1	-2.0	-2.0	-2.0	-1.7	1.7
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.3	0.3	-0.2	-0.2	-0.2	-0.0	0.1
Pavlov. Cond. index score	0.3	0.4	0.8	0.9	0.9	-0.6	-0.5	-0.5	-0.1	0.3
Pavlov. Cond. latency score	0.2	0.3	0.8	0.9	0.9	-0.5	-0.4	-0.4	0.1	0.1
Pavlov. Cond. lever contacts	0.2	0.2	0.7	0.2	0.2	0.2	0.3	0.3	0.9	-0.7
Pavlov. Cond. magazine entry number	0.8	1.0	1.2	-1.1	-1.1	1.0	1.0	1.0	0.9	-1.0
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	0.2	0.3	-0.5	-0.6	-0.6	-0.9	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.0	1.0	1.0	-0.7	-0.6	-0.6	-0.3	0.4
Pavlov. Cond. response bias	0.8	0.9	1.2	1.1	1.1	-1.0	-1.0	-1.0	-0.8	0.9
Pavlov. Cond. lever latency	0.8	1.1	1.8	-0.9	-0.9	1.1	1.1	1.1	1.0	-1.3
Pavlov. Cond. magazine entry latency	0.4	0.5	0.8	0.7	0.6	-0.7	-0.7	-0.7	-0.7	0.9
Pavlov. Cond. change in total contacts	0.6	1.0	1.2	0.8	0.8	-1.0	-1.0	-1.0	-1.0	1.1
Pavlov. Cond. index score	0.7	1.0	1.6	0.8	0.8	-1.0	-1.0	-1.0	-1.0	1.3
Pavlov. Cond. latency score	0.7	0.9	1.2	0.8	0.8	-1.0	-1.0	-1.0	-0.9	1.1
Pavlov. Cond. lever contacts	0.7	1.0	1.9	0.7	0.7	-1.0	-1.0	-1.0	-1.1	1.4
Pavlov. Cond. magazine entry number	0.7	0.8	1.1	-0.9	-0.9	0.9	0.9	0.9	0.8	-1.1
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	-0.7	-0.7	0.5	0.5	0.5	0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	1.3	0.9	0.9	-1.0	-1.0	-1.0	-0.9	1.2
Pavlov. Cond. response bias	1.9	2.6	4.1	1.3	1.3	-1.6	-1.6	-1.6	-1.7	2.0
Time in closed arm before self-admin	0.6	0.8	1.7	-0.5	-0.5	0.8	0.9	0.9	1.3	-1.0
Time in closed arm after self-admin	0.4	0.4	1.4	0.3	0.3	-0.5	-0.5	-0.5	-0.8	1.2
Time in open arm before self-admin	0.1	0.2	0.4	0.4	0.4	-0.5	-0.5	-0.6	-0.2	-0.1
Time in open arm after self-admin	1.1	1.2	1.8	-1.1	-1.1	1.1	1.1	1.0	0.9	-1.3
Bone: periosteal estimation	0.3	0.7	1.3	-0.5	-0.6	0.8	0.9	0.9	1.1	-0.9
Bone: periosteal perimeter	0.0	0.1	0.2	0.4	0.4	-0.2	-0.1	-0.1	0.3	-0.1
Bone: post-yield work	0.6	0.8	1.1	-1.1	-1.1	1.0	1.0	1.0	0.6	-0.5
Progressive ratio test 1 active lever presses	0.2	0.3	1.0	0.1	0.1	-0.5	-0.5	-0.4	-1.0	0.6
Progressive ratio test 1 breakpoint	0.2	0.3	0.9	0.0	0.0	-0.4	-0.5	-0.3	-1.0	0.6
Progressive ratio test 1 inactive lever presses	0.3	0.5	0.8	0.5	0.5	-0.7	-0.7	-0.6	-0.9	0.8
Progressive ratio test 2 active lever presses	0.5	0.6	1.6	0.2	0.2	-0.8	-0.9	-0.7	-1.3	0.6
Progressive ratio test 2 breakpoint	0.6	0.7	1.8	0.3	0.3	-0.9	-1.0	-0.8	-1.3	0.7
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	0.3	0.3	-0.6	-0.6	-0.4	-0.4	-0.0
Incentive Sensitization - Responses	0.1	0.1	0.4	-0.3	-0.3	-0.3	-0.4	-0.2	-0.6	-0.1
Incentive Sensitization - Breakpoint	0.1	0.1	0.5	-0.2	-0.1	-0.3	-0.5	-0.3	-0.7	-0.0
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.1	-0.1	0.1	0.0	0.0	0.1	0.3
Progressive ratio	0.2	0.4	0.8	-0.6	-0.6	0.6	0.6	0.5	0.2	-0.9
Food seeking constrained by brief footshock	0.1	0.2	0.4	0.6	0.6	-0.4	-0.4	-0.3	-0.1	-0.0
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	0.8	0.7	-0.6	-0.5	-0.4	-0.1	0.6
Retroperitoneal fat weight	0.3	1.2	2.1	-1.5	-1.4	1.2	1.1	1.2	0.4	-0.5
Reaction time number correct	0.2	0.4	1.0	-1.0	-1.0	0.5	0.4	0.4	-0.4	0.3
Reaction time mean minus median	0.3	0.8	0.9	0.8	0.8	-0.9	-0.9	-0.9	-1.0	0.9
Reaction time mean minus median AUC	0.0	0.1	0.3	0.0	0.0	0.2	0.3	0.3	0.5	-0.5
Reaction time num false alarms	0.1	0.2	0.4	-0.6	-0.6	0.2	0.2	0.2	-0.4	0.2
Reaction time num false alarms AUC	0.1	0.2	0.5	-0.7	-0.7	0.2	0.1	0.2	-0.5	0.2
Reaction time trials correct on left	0.2	0.4	1.0	-1.0	-1.0	0.5	0.4	0.4	-0.4	0.3
Reaction time trials on left	0.2	0.4	1.0	-1.0	-1.0	0.5	0.4	0.5	-0.4	0.2
Reaction time mean	0.1	0.1	0.2	-0.1	-0.2	0.3	0.3	0.3	0.4	-0.5
Reaction time mean AUC	0.1	0.1	0.3	-0.2	-0.2	0.3	0.4	0.3	0.5	-0.5
Median of all reaction times	0.4	0.6	0.9	-0.5	-0.6	0.7	0.8	0.7	0.9	-0.9
Reaction time omissions	0.1	0.1	0.3	0.5	0.5	-0.3	-0.3	-0.2	0.2	-0.1
Reaction time false alarm rate	0.0	0.0	0.1	-0.3	-0.3	0.2	0.2	0.2	0.1	-0.1
Reaction time premature initiation rate	1.1	1.5	2.0	1.1	1.1	-1.2	-1.3	-1.3	-1.4	1.3
Reaction time premature initiations	0.8	1.5	3.1	0.6	0.7	-1.1	-1.2	-1.2	-1.8	1.6
Std. dev. reaction times	0.1	0.1	0.1	0.4	0.3	-0.4	-0.3	-0.4	-0.3	0.3
Reaction time trials completed	0.2	0.4	1.0	-1.0	-1.0	0.5	0.4	0.5	-0.4	0.2
Reaction time trials AUC	0.2	0.4	1.1	-1.0	-1.0	0.5	0.4	0.4	-0.6	0.4
Run reversals in cocaine runway, females	0.4	0.4	0.7	0.9	0.8	-0.7	-0.6	-0.5	-0.3	0.5
Run reversals in cocaine runway, males	1.6	1.6	2.2	1.5	1.5	-1.2	-1.2	-1.1	-0.8	1.4
Latency to leave start box in cocaine runway	0.3	0.3	0.7	0.8	0.8	-0.7	-0.6	-0.4	0.2	-0.3
Latency to leave start box in cocaine runway, F	0.5	0.5	1.8	0.1	0.0	0.0	0.2	0.5	1.2	-1.4
Latency to leave start box in cocaine runway, M	2.1	2.0	2.3	1.3	1.3	-1.4	-1.4	-1.5	-1.5	1.5
Std. dev. time between licks in bursts	0.5	0.7	1.0	1.0	1.0	-0.9	-0.8	-0.8	-0.5	0.3
Total sessions with >9 infusions	0.4	0.5	0.8	0.4	0.4	-0.8	-0.9	-0.6	-0.9	0.9
Short access day 1 total inactive lever presses	0.3	0.4	0.7	0.6	0.6	-0.8	-0.8	-0.7	-0.7	0.3
Short access day 10 total inactive lever presses	0.0	0.1	0.1	-0.2	-0.2	-0.2	-0.3	-0.2	-0.4	0.3
Short access day 1 total infusions	0.3	0.4	0.6	0.6	0.6	-0.7	-0.7	-0.6	-0.7	0.6
Short access day 10 total infusions	0.2	0.2	0.6	0.1	0.1	-0.4	-0.5	-0.2	-0.8	0.5
Short access total infusions	0.4	0.5	0.8	0.5	0.5	-0.8	-0.9	-0.6	-0.8	0.6
Short access day 1 locomotion	1.6	2.0	2.6	1.2	1.3	-1.5	-1.5	-1.4	-1.4	1.6
Short access day 10 total locomotion	4.9	9.1	10.9	2.6	2.6	-3.2	-3.3	-3.0	-3.2	3.0
Short access total locomotion	2.9	3.5	4.3	1.5	1.6	-2.0	-2.1	-1.8	-1.9	2.1
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.1	0.1	-0.2	-0.2
Compulsive drug intake	1.5	1.8	3.3	-0.9	-1.0	1.2	1.3	1.4	1.8	-1.5
One hour access (shock baseline)	0.6	0.9	2.0	0.6	0.6	-0.9	-1.0	-0.9	-1.4	0.9
Social response proportion	0.6	0.7	1.3	1.1	1.1	-0.8	-0.8	-0.8	-0.3	-0.1
Social responses	6.1	7.9	10.1	3.2	3.1	-3.1	-3.0	-2.9	-2.1	2.1
Social time	0.4	0.5	0.6	-0.7	-0.7	0.8	0.7	0.7	0.7	-0.8
Soleus weight	7.9	23.3	27.3	-5.2	-5.2	5.1	5.0	5.0	4.1	-3.9
Bone: stiffness	2.8	4.6	5.1	-2.1	-2.1	2.2	2.3	2.3	2.1	-2.0
Tibialis anterior weight	1.0	3.5	4.2	-2.0	-2.0	2.0	2.0	2.0	1.5	-1.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.5	0.3	0.3	-0.2	-0.2	-0.1	0.1	0.7
Time to tail flick, vehicle, after self-admin	0.6	0.8	2.0	0.4	0.4	-0.6	-0.7	-0.6	-1.4	1.3
Time to tail flick, test, before self-admin	0.2	0.2	0.4	0.7	0.6	-0.4	-0.4	-0.5	0.0	0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.4	0.3	0.3	-0.2	-0.2	-0.2	-0.3	0.6
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	-0.6	-0.5	0.2	0.1	0.3	-0.6	0.1
Delta time to tail flick, test, before/after SA	0.2	0.2	0.6	-0.1	-0.1	-0.1	-0.2	-0.2	-0.7	0.7
Tibia length	0.8	2.3	2.6	1.5	1.5	-1.6	-1.6	-1.6	-1.4	1.3
Ambulatory time before self-admin	0.1	0.2	0.4	-0.4	-0.4	0.4	0.4	0.6	0.6	-0.4
Ambulatory time after self-admin	0.0	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.2	0.0
Bone: tissue strength	2.1	2.1	2.5	-1.4	-1.4	1.5	1.5	1.5	1.5	-1.6
Total heroin consumption	1.4	1.6	2.1	1.5	1.5	-1.3	-1.3	-1.2	-0.9	1.2
Bone: trabecular number	0.2	0.3	0.8	0.9	0.9	-0.5	-0.4	-0.4	0.2	0.0
Bone: trabecular spacing	0.3	0.4	1.0	-1.0	-0.9	0.3	0.1	0.1	-0.9	0.6
Bone: trabecular thickness	1.0	1.3	4.2	0.2	0.1	0.5	0.7	0.7	2.0	-1.8
Bone: trabecular tissue density	1.1	1.7	2.1	-1.5	-1.4	1.3	1.3	1.3	1.0	-1.2
Water consumed over 24 hours	0.7	1.0	1.3	-0.9	-1.0	1.0	1.1	1.1	1.1	-0.7
Number of responses in last shaping day	2.1	2.3	3.1	1.2	1.2	-1.6	-1.7	-1.4	-1.7	1.8