Padi2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Padi2	0.51	0.12	1.5e-07	0.16	0.14	0.16	0.16	1.1e-04	2.5e-04	8.9e-05	1.2e-04
2	OFC	gene expression	Padi2	0.3	0.13	1.5e-04	0.23	0.13	0.19	0.18	3.0e-06	6.4e-04	2.9e-05	4.7e-05
3	Brain	gene expression	Padi2	0.66	0.1	0.0e+00	0.52	0.57	0.58	0.58	8.6e-56	3.1e-64	3.6e-65	1.4e-65
4	PL	gene expression	Padi2	0.53	0.11	0.0e+00	0.4	0.44	0.43	0.44	3.0e-46	3.8e-52	1.7e-51	5.0e-52
5	IC	gene expression	Padi2	0.6	0.12	0.0e+00	0.44	0.51	0.51	0.52	1.8e-20	2.3e-24	2.2e-24	3.7e-25
6	NAcc	gene expression	Padi2	0.12	0.05	4.4e-15	0.11	0.1	0.1	0.11	9.0e-16	5.5e-15	3.4e-15	6.0e-16
7	BLA	gene expression	Padi2	0.47	0.12	2.2e-16	0.23	0.27	0.27	0.28	2.9e-12	8.9e-15	1.2e-14	2.7e-15
8	LHb	gene expression	Padi2	0.54	0.12	3.2e-08	0.16	0.18	0.17	0.16	9.8e-05	4.6e-05	8.9e-05	1.1e-04
9	pVTA	gene expression	Padi2	0.29	0.09	0.0e+00	0.28	0.29	0.3	0.3	7.3e-23	5.8e-24	1.9e-24	4.7e-24
10	Liver	gene expression	Padi2	0.35	0.1	0.0e+00	0.27	0.25	0.25	0.26	1.4e-29	1.5e-27	6.2e-28	6.8e-29
11	Eye	gene expression	Padi2	0.73	0.12	5.9e-07	0.25	0.16	0.25	0.24	8.3e-05	1.8e-03	1.1e-04	1.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	1.4	2.6	4.1	-1.4	-1.4	1.7	1.6	1.8	1.1	1.8	1.5	-2.0	2.0	-1.2
Area under the delay curve	0.1	0.1	0.4	-0.3	-0.2	0.4	0.3	0.2	0.4	0.1	-0.4	0.1	-0.0	0.6
BMI with tail	0.5	1.7	4.1	1.8	2.0	-1.2	-1.4	-1.0	-1.7	-1.0	-0.7	0.4	-0.8	1.1
BMI without tail	0.1	0.5	1.5	1.1	1.1	-0.8	-0.8	-0.5	-1.2	-0.3	0.1	-0.2	0.1	0.3
Body weight	0.1	0.5	1.9	0.9	1.1	-0.4	-0.5	-0.0	-1.1	-0.0	-0.3	-0.5	0.0	1.4
Weight adjusted by age	0.4	1.0	2.3	1.2	1.0	-1.3	-1.4	-0.9	-1.5	-0.9	-0.7	0.5	-0.8	0.4
Bone surface	1.3	2.5	4.2	-1.4	-1.4	1.5	1.5	1.8	0.9	1.9	1.5	-2.0	2.0	-1.1
Bone volume	1.1	2.2	3.8	-1.3	-1.3	1.5	1.4	1.7	0.9	1.7	1.2	-1.7	1.9	-1.1
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1	-0.2	0.4	-0.3	0.1	0.2	-0.2	-0.2
Number of licking bursts	0.2	0.7	3.6	-0.9	-1.0	0.7	0.7	0.5	0.5	0.5	0.8	-0.2	0.6	-1.9
Context. condit. distance diff. score	0.5	0.6	1.2	-0.8	-0.7	0.9	0.9	0.8	0.7	0.7	0.8	-0.3	0.4	-1.1
Locomotion velocity, session 1	0.3	0.3	1.2	-0.2	-0.3	-0.0	0.2	-0.4	0.3	-0.5	-0.2	0.9	-1.1	-0.7
Locomotion distance, session 1	0.3	0.3	0.9	-0.8	-0.7	0.6	0.8	-0.0	0.9	-0.1	-0.1	0.6	-0.7	-0.3
Locomotion velocity, session 2	0.2	0.3	1.3	-0.2	-0.1	-0.1	0.1	-0.4	0.5	-0.6	-0.5	0.9	-1.1	-0.2
Locomotion distance, session 2	1.1	1.6	2.9	0.8	1.0	-0.9	-0.7	-1.2	-0.6	-1.4	-1.5	1.5	-1.6	1.7
Locomotion velocity, session 3	0.1	0.1	0.3	-0.4	-0.1	0.4	0.4	0.3	0.5	0.2	0.4	0.0	0.2	-0.6
Locomotion distance, session 3	0.1	0.1	0.7	-0.2	-0.2	-0.0	0.2	0.2	-0.1	0.2	0.1	0.2	0.4	-0.8
Stereotopy head waving bouts, day 3	0.5	0.6	1.8	0.4	0.6	-0.4	-0.5	-0.8	-0.1	-0.9	-0.8	0.7	-1.0	1.4
Stereotopy head waving duration, day 3	0.1	0.1	0.5	-0.0	0.2	0.0	-0.1	-0.5	0.4	-0.5	-0.1	0.3	-0.7	0.5
Locomotion velocity, session 7	0.8	0.9	2.6	-0.6	-0.7	0.6	0.6	0.9	0.2	1.0	1.2	-0.8	1.3	-1.6
Locomotion distance, session 7	0.2	0.3	0.8	-0.4	-0.7	0.1	0.3	0.4	-0.1	0.6	0.5	-0.2	0.7	-0.9
Stereotopy head waving bouts, day 7	0.5	0.6	0.9	-0.7	-0.5	0.8	0.8	0.6	0.9	0.7	0.8	-0.7	0.8	-0.8
Stereotopy head waving duration, day 7	0.7	0.8	1.5	-0.9	-0.7	1.0	0.9	0.7	1.2	0.7	0.9	-0.7	0.8	-1.2
Locomotion velocity, session 8	0.9	1.0	2.5	0.9	0.9	-0.9	-0.8	-1.0	-0.9	-1.0	-1.3	1.6	-1.2	0.3
Locomotion distance, session 8	0.2	0.3	0.9	-0.6	-0.4	0.8	0.9	0.7	0.5	0.5	0.3	-0.1	0.2	-0.1
Degree of sensitization distance	0.3	0.3	0.6	0.5	0.3	-0.6	-0.7	-0.5	-0.6	-0.5	-0.3	0.3	-0.6	0.8
Degree of sensitization stereotypy	1.2	1.3	1.9	-1.0	-0.8	1.2	1.2	1.2	1.1	1.2	1.3	-1.3	1.4	-1.0
Conditioned locomotion	0.8	0.9	1.7	-1.1	-1.1	1.1	1.3	1.0	1.3	0.9	0.6	-0.6	0.4	0.2
Cocaine response after cond. corrected	5.4	8.1	10.8	3.3	3.2	-3.2	-3.2	-3.0	-3.1	-2.8	-2.4	2.4	-2.1	2.4
Cocaine response after cond. not corrected	2.7	3.9	5.5	2.3	2.2	-2.3	-2.3	-2.1	-2.2	-1.9	-1.5	1.6	-1.3	1.5
Cocaine response before conditioning	3.4	4.1	5.6	-2.4	-2.3	2.1	2.2	1.8	2.3	1.8	2.0	-1.6	1.5	-2.2
Saline control response	2.5	3.5	4.2	-1.9	-1.9	2.0	2.0	2.0	2.0	2.0	1.9	-2.1	1.7	-0.7
Bone: connectivity density	1.4	2.3	4.8	-1.2	-1.3	1.3	1.4	1.7	0.9	1.7	1.7	-2.2	1.7	-1.1
Bone: cortical apparent density	0.4	0.6	1.2	-0.9	-1.1	0.6	0.8	0.5	1.0	0.4	0.9	-0.6	-0.0	-0.9
Bone: cortical area	3.1	5.0	6.3	-2.3	-2.2	2.5	2.4	2.5	2.0	2.4	2.1	-2.4	2.1	-1.4
Bone: cortical porosity	0.3	0.3	0.8	-0.8	-0.9	0.6	0.7	0.3	0.8	0.4	0.1	-0.0	0.2	0.4
Bone: cortical porosity	0.7	0.7	2.3	0.3	0.3	-0.5	-0.5	-0.9	-0.4	-0.8	-1.1	1.2	-0.9	1.5
Bone: cortical thickness	6.2	10.3	13.0	-3.5	-3.2	3.6	3.5	3.4	3.3	3.3	3.3	-3.1	2.7	-2.3
Bone: cortical thickness	3.2	4.0	5.3	-2.1	-2.0	2.1	2.1	2.2	2.0	2.3	1.7	-1.9	2.1	-1.1
Bone: cortical tissue density	0.2	0.4	0.9	-0.6	-0.9	0.3	0.6	0.3	0.8	0.2	0.8	-0.4	-0.1	-0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.3	-0.2	-0.2	-0.3	-0.5	-0.0	-0.5	-0.4	0.5	-0.4	-0.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.1	0.3	-0.3	-0.4	-0.6	-0.0	-0.7	-0.5	0.4	-0.7	0.4
Condit. Reinf. active responses	0.2	0.3	1.9	-0.6	-0.6	0.1	0.1	-0.2	0.4	-0.1	0.0	0.3	-0.1	-1.4
Condit. Reinf. inactive responses	0.1	0.2	1.5	-0.3	-0.4	0.1	0.1	0.1	0.0	0.1	0.3	0.2	0.0	-1.2
Incentive salience index mean	0.2	0.2	0.8	-0.8	-0.7	0.3	0.2	-0.2	0.5	-0.2	-0.1	0.3	-0.4	-0.9
Condit. Reinf. lever presses	0.5	0.7	2.4	-1.1	-1.0	0.8	0.8	0.5	1.0	0.4	0.5	-0.3	0.0	-1.6
Condit. Reinf. active minus inactive responses	0.0	0.1	0.2	0.3	0.4	0.1	-0.1	0.2	-0.1	0.1	0.1	-0.4	0.3	0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	0.7	0.7	-0.5	-0.6	-0.6	-0.4	-0.5	-0.3	0.3	-0.0	0.2
Condit. Reinf. active responses	0.4	0.5	0.9	-0.6	-0.5	0.9	0.8	1.0	0.6	0.9	0.5	-0.8	0.8	-0.1
Condit. Reinf. inactive responses	1.4	2.0	3.1	-1.8	-1.7	1.7	1.8	1.6	1.5	1.5	1.0	-1.2	1.0	-0.5
Condit. Reinf. lever presses	0.2	0.2	0.3	-0.6	-0.6	0.5	0.5	0.6	0.2	0.5	0.2	-0.4	0.6	-0.3
Condit. Reinf. lever reinforcers received	0.2	0.3	0.7	-0.4	-0.2	0.6	0.6	0.8	0.3	0.7	0.3	-0.7	0.8	0.1
Conditioned reinforcement - actives	0.0	0.1	0.6	-0.3	-0.3	0.1	0.2	-0.1	0.2	0.1	0.4	-0.3	0.1	-0.8
Conditioned reinforcement - inactives	0.2	0.5	0.7	0.7	0.8	-0.7	-0.7	-0.7	-0.8	-0.7	-0.5	0.8	-0.6	0.3
Conditioned locomotion	0.1	0.2	0.5	0.1	0.2	-0.3	-0.2	-0.6	-0.2	-0.5	-0.2	0.5	-0.7	-0.1
Patch foraging indifference point 0 sec	3.5	9.8	13.0	-3.3	-3.2	3.4	3.6	3.3	3.1	3.1	3.4	-3.4	2.6	-1.6
Patch foraging indifference point AUC	1.5	3.6	5.5	-2.0	-2.1	1.7	1.7	1.8	1.7	2.0	1.8	-1.5	2.0	-2.4
Delay disc. indifference point, 0s delay	0.2	0.3	1.0	-0.0	0.0	0.1	0.0	-0.2	0.3	-0.4	-1.0	0.7	-0.7	0.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.5	-0.0	0.2	0.3	0.0	-0.1	0.3	-0.1	-0.5	0.3	-0.1	0.7
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	-0.5	-0.4	0.5	0.4	0.6	0.4	0.5	-0.1	-0.2	0.2	0.6
Delay disc. indifference point, 24s delay	0.2	0.4	0.6	-0.7	-0.6	0.7	0.6	0.6	0.7	0.6	0.3	-0.6	0.8	0.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.5	0.2	0.3	-0.1	-0.1	-0.2	0.0	-0.3	-0.5	0.3	-0.6	0.7
Delay disc. indifference point, 8s delay	0.4	0.6	1.6	0.4	0.5	-0.5	-0.6	-0.8	-0.4	-0.8	-1.2	1.0	-0.7	1.3
Indifference point function ln k	1.8	5.4	7.4	2.2	2.3	-2.1	-2.0	-2.4	-1.8	-2.6	-2.4	2.4	-2.7	2.7
Indifference point function log k	1.8	5.4	7.4	2.2	2.3	-2.1	-2.0	-2.4	-1.8	-2.6	-2.4	2.4	-2.7	2.7
Patch foraging total patch changes 0 sec	3.1	9.1	12.3	-3.3	-3.1	3.3	3.5	3.2	3.1	2.9	3.2	-3.1	2.4	-1.5
Patch foraging total patch changes 12 sec	9.4	12.5	14.3	-3.8	-3.7	3.6	3.7	3.7	3.4	3.6	3.5	-3.4	3.3	-3.1
Patch foraging total patch changes 18 sec	11.0	26.0	31.8	-5.6	-5.6	5.2	5.3	5.3	5.1	5.1	5.2	-4.9	4.4	-4.2
Patch foraging total patch changes 24 sec	3.6	12.3	15.4	-3.8	-3.9	3.6	3.6	3.8	3.1	3.7	3.4	-3.5	3.5	-2.3
Patch foraging total patch changes 6 sec	7.4	12.6	14.4	-3.8	-3.8	3.6	3.7	3.7	3.2	3.6	3.7	-3.6	3.3	-2.8
Patch foraging time to switch 0 sec	0.0	0.1	0.6	0.5	0.3	-0.5	-0.4	-0.1	-0.8	-0.1	-0.1	-0.2	0.1	-0.0
Patch foraging water rate 0 sec	0.6	2.2	3.3	-1.8	-1.8	1.5	1.6	1.2	1.7	1.3	1.5	-1.1	1.1	-1.5
Patch foraging water rate 12 sec	0.1	0.4	0.9	-0.7	-0.5	0.8	0.8	0.5	1.0	0.5	0.5	-0.5	0.3	-0.1
Patch foraging water rate 18 sec	0.8	1.7	2.6	1.1	1.2	-1.2	-1.2	-1.5	-1.0	-1.5	-1.3	1.5	-1.6	1.3
Patch foraging water rate 24 sec	0.3	0.4	0.9	0.5	0.3	-0.8	-0.5	-0.8	-0.6	-0.7	-0.5	1.0	-0.7	0.4
Patch foraging water rate 6 sec	0.7	1.0	1.6	-1.2	-1.2	1.1	1.2	0.9	1.3	0.9	1.0	-0.8	0.9	-0.3
Seeking ratio, delayed vs. immediate footshock	0.9	1.2	2.5	1.4	1.6	-1.1	-1.2	-1.2	-0.8	-1.2	-1.1	0.9	-0.8	0.6
Distance traveled before self-admin	1.3	2.8	4.9	-1.7	-1.5	1.8	1.6	1.5	1.8	1.6	1.8	-1.5	1.4	-2.2
Distance traveled after self-admin	1.4	2.5	4.6	-1.6	-1.7	1.5	1.5	1.5	1.4	1.4	1.8	-1.5	1.1	-2.2
Extensor digitorum longus weight	0.0	0.1	0.2	-0.1	0.1	0.3	0.3	0.3	0.1	0.1	0.3	-0.4	-0.1	-0.3
Bone: elastic displacement	3.6	4.6	7.0	-2.4	-2.7	2.1	2.3	2.0	2.1	2.0	2.4	-1.9	1.8	-1.7
Bone: elastic work	4.8	6.3	9.3	-2.9	-3.1	2.6	2.7	2.4	2.3	2.5	2.6	-2.2	2.2	-1.8
Bone: endosteal estimation	1.9	4.6	8.1	2.5	2.6	-2.3	-2.3	-1.8	-2.9	-1.7	-2.1	1.5	-1.1	2.1
Bone: endosteal perimeter	1.3	3.1	4.6	2.0	2.1	-1.8	-1.7	-1.5	-2.1	-1.6	-1.8	1.4	-1.3	1.8
Epididymis fat weight	0.5	2.7	5.4	2.0	2.3	-1.4	-1.6	-1.4	-1.5	-1.5	-1.6	1.3	-1.4	1.6
Delta time in closed arm before/after self-admin	4.5	4.2	6.6	2.4	2.6	-1.9	-2.0	-1.6	-1.8	-1.6	-2.5	2.0	-1.4	2.4
Delta time in open arm before/after self-admin	1.7	2.0	3.9	1.2	1.2	-1.4	-1.3	-1.7	-1.2	-1.8	-1.2	1.6	-2.0	0.6
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.1	-0.3	0.0	0.0	0.2	-0.1	0.2	0.3	-0.5	0.5	-0.5
Delay discount exponential model param	0.1	0.1	0.4	0.3	0.1	-0.4	-0.3	-0.2	-0.3	-0.1	0.3	-0.0	-0.1	-0.7
Extinction: sum of active levers before priming	0.4	0.6	2.7	-0.3	-0.3	-0.3	-0.2	-0.9	0.3	-0.9	-0.8	0.8	-1.6	0.6
Active lever presses in extinction session 6	2.6	2.7	3.4	1.4	1.2	-1.8	-1.7	-1.8	-1.7	-1.7	-1.8	1.7	-1.7	1.3
Bone: final force	2.1	3.4	4.7	-1.8	-1.8	1.9	1.9	2.1	1.5	2.2	1.7	-2.0	2.0	-0.9
Bone: final moment	1.6	2.6	3.6	-1.6	-1.6	1.8	1.7	1.9	1.4	1.9	1.5	-1.7	1.7	-0.8
Food consumed during 24 hour testing period	0.1	0.3	0.6	0.6	0.7	-0.4	-0.5	-0.3	-0.8	-0.4	-0.5	-0.1	-0.1	0.6
Glucose	0.0	0.0	0.1	-0.2	-0.1	0.2	0.1	0.3	-0.2	0.2	0.4	-0.3	0.1	-0.1
Heart weight	0.9	1.5	2.4	-1.2	-1.2	1.2	1.0	1.0	1.2	1.1	1.4	-1.6	1.1	-1.4
Delay discount hyperbolic model param	0.1	0.1	0.5	0.3	0.2	-0.5	-0.4	-0.3	-0.5	-0.2	0.3	0.0	-0.1	-0.7
Intermittent access intake day 1-15 change	0.0	0.2	0.5	-0.2	-0.1	0.3	0.2	0.6	-0.0	0.5	0.7	-0.7	0.4	-0.6
Intermittent access intake escalation	0.0	0.1	0.3	0.2	0.2	-0.1	-0.1	0.3	-0.4	0.2	0.4	-0.5	0.2	-0.4
Intermittent access intake escalation 2	0.0	0.1	0.2	0.3	0.2	-0.3	-0.2	0.0	-0.5	-0.1	0.0	-0.2	-0.1	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.0	0.1	0.1	0.1	-0.0	0.0	-0.1	-0.0	0.3	0.0	-0.2
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.6	0.3	0.5	-0.5	-0.5	-0.6	-0.6	-0.6	-0.6	0.8	-0.6	0.5
Intermitt. access escalation Index	0.5	1.5	2.5	-1.5	-1.6	1.3	1.3	1.0	1.3	1.2	1.2	-0.8	1.1	-1.0
Intermittent access day 1 total infusions	0.6	1.9	2.9	1.2	1.1	-1.6	-1.4	-1.7	-1.4	-1.6	-1.3	1.5	-1.4	0.7
Intermittent access day 15 total infusions	1.1	2.6	4.0	1.7	1.7	-1.9	-1.8	-1.7	-2.0	-1.7	-1.3	1.4	-1.4	0.7
Intermittent access terminal intake (last 3 days)	1.0	1.7	3.3	1.5	1.4	-1.7	-1.5	-1.4	-1.8	-1.3	-0.9	0.8	-1.0	0.2
Intermittent access total infusions	3.5	4.1	5.7	2.0	1.9	-2.4	-2.2	-2.3	-2.3	-2.2	-1.7	1.9	-2.0	0.8
Intermittent access day 1 locomotion	0.5	0.9	1.4	0.9	0.8	-1.1	-1.0	-1.1	-1.0	-1.1	-0.8	1.2	-1.0	0.5
Intermittent access day 15 total locomotion	0.3	1.0	1.5	1.2	1.1	-1.2	-1.1	-0.9	-1.2	-0.9	-0.7	1.0	-0.9	0.6
Intermittent access total locomotion	0.4	0.5	1.1	0.8	0.6	-1.0	-0.8	-0.8	-1.1	-0.7	-0.2	0.6	-0.7	0.1
Intermittent access standard deviation	0.1	0.7	1.3	1.0	1.2	-0.7	-0.8	-1.0	-0.7	-1.0	-0.7	0.7	-0.9	-0.0
Left kidney weight	0.1	0.8	1.4	-0.8	-0.7	1.0	0.8	0.9	1.0	0.9	0.7	-1.2	0.9	-0.8
Right kidney weight	0.0	0.1	0.3	-0.3	-0.1	0.5	0.4	0.4	0.3	0.4	0.2	-0.6	0.3	0.0
Cocaine induced anxiety	1.1	2.9	3.2	-1.8	-1.8	1.7	1.6	1.6	1.6	1.7	1.8	-1.8	1.7	-1.7
Post-drug Anxiety	3.5	4.0	5.8	-1.9	-1.8	1.9	1.8	2.2	1.7	2.0	2.0	-2.4	2.1	-2.2
Baseline Anxiety	0.4	0.6	1.2	-0.6	-0.6	0.6	0.7	1.0	0.6	0.8	0.6	-1.0	0.7	-1.1
Tail length	0.0	0.1	0.3	0.1	-0.1	-0.2	-0.0	0.2	-0.6	0.4	-0.0	-0.3	0.5	0.5
Length with tail	0.1	0.4	1.1	-0.2	-0.2	0.3	0.5	0.8	-0.2	0.9	0.2	-0.9	0.7	1.1
Length without tail	0.1	0.3	2.1	0.2	0.3	0.2	0.2	0.6	-0.3	0.5	-0.2	-0.5	0.3	1.5
Times rat made contact with spout	0.2	0.2	0.7	-0.8	-0.7	0.5	0.5	0.2	0.8	0.0	-0.2	0.1	-0.4	-0.1
Lifetime Intake	3.4	4.2	5.9	2.0	1.9	-2.4	-2.2	-2.4	-2.3	-2.2	-1.8	2.0	-2.0	0.7
Liver weight, left	1.3	2.3	3.8	1.4	1.8	-1.1	-1.3	-1.4	-0.9	-1.6	-1.8	1.4	-1.9	1.5
Liver weight, right	1.5	2.6	4.0	1.7	1.7	-1.5	-1.5	-1.4	-1.6	-1.4	-1.5	1.4	-1.7	2.0
Locomotor activity	4.0	6.2	8.5	-2.4	-1.9	2.9	2.7	2.6	2.8	2.4	2.6	-2.8	1.8	-1.9
Locomotor testing distance	2.2	5.3	7.5	-2.6	-2.4	2.5	2.5	1.9	2.7	1.7	2.6	-2.2	1.0	-2.5
Locomotor testing rearing	0.9	3.4	5.9	-2.2	-2.0	1.9	1.9	1.4	2.4	1.1	2.1	-1.5	0.5	-2.4
Locomotion in novel chamber	1.7	2.2	2.9	-1.7	-1.6	1.6	1.5	1.6	1.4	1.5	1.4	-1.7	1.6	-0.6
Locomotion in novel chamber post-restriction	0.6	1.7	2.3	-1.2	-1.0	1.5	1.2	1.4	1.3	1.4	1.3	-1.5	1.4	-1.0
Fecal boli incidents, locomotor time 1	0.1	0.2	0.5	0.1	0.3	0.4	0.2	0.5	0.2	0.7	0.6	-0.6	0.7	0.3
Change in fecal boli incidents, locomotor task	0.8	0.9	1.6	0.8	0.5	-1.1	-1.0	-1.3	-0.9	-1.3	-0.9	1.0	-0.9	0.4
Time >=10cm from walls, locomotor time 1	1.2	1.5	2.4	-0.8	-0.5	1.3	1.1	1.4	0.9	1.4	1.5	-1.5	1.4	-1.1
Bouts of movement, locomotor time 1	0.2	0.3	1.0	0.1	-0.1	-0.2	-0.2	0.4	-0.4	0.5	0.6	-1.0	1.0	-0.1
Total resting periods, locomotor time 1	0.4	0.4	1.7	-0.1	-0.3	-0.0	-0.0	0.5	-0.4	0.7	0.8	-1.1	1.3	-0.2
Rest time, locomotor task time 1	0.1	0.2	1.4	0.0	-0.2	-0.1	-0.1	0.2	-0.2	0.6	0.7	-0.5	1.2	-0.1
Distance moved, locomotor task time 1	0.4	1.2	2.4	-1.4	-1.2	1.4	1.5	1.0	1.5	0.5	0.6	-0.5	-0.1	-1.0
Vertical activity count, locomotor time 1	0.1	0.6	1.2	-1.0	-0.8	0.9	1.1	0.7	1.0	0.3	0.3	-0.4	-0.6	-1.1
Time >=10cm from walls, locomotor time 2	0.1	0.4	1.3	-0.4	-0.4	0.5	0.5	0.6	0.4	0.6	0.9	-0.5	0.7	-1.2
Bouts of movement, locomotor time 2	0.1	0.3	0.6	-0.4	-0.5	0.4	0.6	0.7	0.5	0.6	0.7	-0.7	0.4	0.6
Total resting periods, locomotor time 2	0.2	0.6	1.0	-0.7	-0.8	0.7	0.8	0.9	0.8	0.9	0.9	-1.0	0.7	0.3
Rest time, locomotor task time 2	0.5	0.8	2.1	-0.7	-0.8	0.7	0.5	0.8	0.6	1.2	1.1	-1.2	1.4	-0.2
Distance moved, locomotor task time 2	0.4	0.6	1.1	-0.8	-0.8	0.8	1.0	0.9	0.7	0.6	0.7	-0.6	0.4	-0.7
Vertical activity count, locomotor time 2	0.3	0.7	1.4	-0.8	-0.7	0.9	1.1	1.0	0.9	0.7	0.8	-0.7	0.2	-1.2
Light reinforcement 1	0.8	3.5	4.1	-2.0	-2.0	1.9	2.0	2.0	1.8	1.8	2.0	-2.0	1.2	-1.7
Light reinforcement 2	0.2	0.4	1.3	0.6	0.7	-0.5	-0.5	-0.5	-1.1	-0.6	-0.2	0.6	-0.5	-0.4
Bone: marrow area	1.9	4.6	8.0	2.5	2.6	-2.3	-2.3	-1.8	-2.8	-1.7	-2.1	1.5	-1.1	2.2
Bone: maximum diameter	0.2	0.4	0.7	-0.6	-0.6	0.7	0.8	0.8	0.4	0.7	0.4	-0.7	0.6	-0.1
Bone: maximum force	1.3	2.5	3.5	-1.6	-1.5	1.7	1.6	1.8	1.2	1.9	1.5	-1.8	1.7	-0.8
Bone: maximum moment	0.9	1.7	2.4	-1.3	-1.2	1.5	1.4	1.5	1.0	1.6	1.3	-1.4	1.4	-0.6
Mean time between licks in bursts	0.0	0.1	0.3	0.1	0.2	-0.0	-0.2	-0.3	-0.2	-0.3	-0.6	0.2	-0.5	0.3
Mean num. licks in bursts	0.2	0.5	3.1	0.4	0.4	-0.4	-0.4	-0.4	-0.1	-0.6	-0.8	0.3	-0.9	1.8
Cd content in liver	0.5	0.5	2.2	0.5	0.5	0.2	0.3	0.8	-0.2	0.9	0.8	-0.8	1.5	0.1
Co content in liver	0.2	0.2	0.7	-0.2	-0.0	0.6	0.3	0.5	0.8	0.2	0.3	-0.7	-0.0	-0.7
Cu content in liver	3.5	4.2	7.1	-1.7	-1.7	2.2	2.0	2.4	1.9	2.3	2.0	-2.7	1.9	-1.3
Fe content in liver	0.0	0.0	0.2	-0.0	-0.3	-0.3	-0.2	-0.1	0.1	-0.1	-0.4	-0.1	-0.2	-0.1
K content in liver	0.0	0.0	0.0	0.0	0.1	0.1	0.2	0.2	0.2	0.0	-0.1	0.1	-0.1	-0.0
Mg content in liver	0.8	0.9	1.4	-0.8	-0.7	1.1	1.1	1.2	0.9	1.0	0.9	-0.9	0.9	-0.3
Mn content in liver	0.2	0.2	0.8	0.7	0.9	-0.2	-0.3	-0.0	-0.3	-0.1	-0.2	-0.1	0.1	0.5
Na content in liver	0.3	0.3	0.8	-0.5	-0.5	0.6	0.7	0.7	0.9	0.5	-0.2	-0.3	0.1	0.4
Rb content in liver	0.2	0.3	0.7	0.6	0.4	-0.6	-0.7	-0.4	-0.8	-0.4	-0.3	0.4	-0.4	0.1
Se content in liver	0.3	0.3	1.6	0.7	0.8	-0.3	-0.3	-0.1	0.1	-0.3	-0.6	-0.1	-0.4	1.3
Sr content in liver	0.2	0.2	0.8	0.3	0.4	-0.2	-0.1	-0.3	-0.2	-0.5	-0.3	0.5	-0.9	0.5
Zn content in liver	0.8	0.9	1.6	-0.5	-0.3	1.1	1.0	1.3	0.7	1.1	1.0	-1.2	1.2	-0.4
Bone: minimum diameter	0.2	0.5	2.1	0.8	0.9	-0.5	-0.6	-0.1	-1.4	-0.1	-0.5	0.0	0.2	0.9
Time in familiar zone, hab. session 1	3.7	4.0	4.7	-1.9	-1.8	2.1	1.9	2.1	2.2	2.1	1.9	-2.2	2.1	-1.8
Time in novel zone, hab. session 1	0.3	0.3	0.6	0.3	0.2	-0.7	-0.4	-0.6	-0.7	-0.6	-0.3	0.7	-0.8	0.6
Total zone transitions, hab. session 1	0.3	0.4	1.0	-1.0	-1.0	0.6	0.8	0.4	0.9	0.4	0.1	0.0	0.1	-0.6
Total locomotion distance, hab. session 1	0.1	0.2	0.4	-0.7	-0.6	0.4	0.4	0.1	0.5	0.2	-0.4	0.6	-0.1	0.1
Locomotion velocity, hab. session 1	0.2	0.2	0.9	-0.4	-0.4	0.1	0.1	-0.3	0.3	-0.2	-0.9	1.0	-0.5	0.5
Time in familiar zone, hab. session 2	1.6	1.8	4.1	-1.4	-1.4	1.1	0.9	1.1	0.9	1.2	1.6	-1.4	1.2	-2.0
Time in novel zone, hab. session 2	0.7	0.7	2.2	0.9	0.8	-0.8	-0.6	-0.8	-0.5	-0.8	-0.8	0.9	-0.6	1.5
Total zone transitions, hab. session 2	0.6	0.8	1.6	0.6	0.6	-0.8	-0.7	-1.1	-0.6	-1.1	-0.9	1.2	-1.3	0.6
Total locomotion distance, hab. session 2	0.1	0.2	0.5	-0.0	0.1	-0.1	-0.1	-0.4	-0.1	-0.4	-0.5	0.7	-0.6	0.7
Locomotion velocity, hab. session 2	0.2	0.3	0.7	0.0	0.2	-0.2	-0.2	-0.5	-0.1	-0.5	-0.7	0.8	-0.7	0.8
Novel to familiar place preference ratio	3.0	3.9	5.8	2.1	1.9	-2.3	-2.2	-2.1	-2.4	-1.9	-1.6	2.0	-1.5	1.4
Novelty place preference	2.8	3.6	5.5	2.0	1.9	-2.2	-2.1	-2.0	-2.3	-1.8	-1.5	2.0	-1.5	1.4
Time in novel zone, NPP test	2.2	2.7	4.3	1.7	1.6	-1.9	-1.8	-1.8	-2.1	-1.6	-1.2	1.8	-1.3	1.1
Total zone transitions, NPP test	1.1	1.6	3.7	-1.7	-1.7	1.5	1.7	0.9	1.9	0.9	0.7	-0.2	0.3	-1.0
Total locomotion distance, NPP test	0.8	1.1	2.3	-1.5	-1.5	1.2	1.4	0.9	1.3	0.9	0.5	-0.2	0.5	-0.3
Locomotion velocity, NPP test	0.4	0.6	1.2	-1.1	-1.1	0.9	1.1	0.7	0.9	0.7	0.2	-0.0	0.4	0.3
Intraocular pressure	0.6	1.0	1.7	1.1	1.3	-0.9	-1.3	-0.7	-1.3	-0.9	-0.9	0.5	-0.8	0.8
Delta distance traveled before/after self-admin	0.6	0.6	2.1	0.8	0.3	-1.2	-1.0	-0.7	-1.4	-0.8	-0.3	0.4	-0.6	0.2
Delta ambulatory time before/after self-admin	1.2	2.0	4.1	1.6	1.3	-1.8	-1.6	-1.3	-2.0	-1.4	-1.0	1.1	-1.2	0.8
Parametrial fat weight	1.0	2.4	4.1	1.3	1.2	-1.5	-1.5	-1.6	-1.4	-1.8	-1.6	1.5	-2.0	1.4
Pavlov. Cond. lever latency	0.1	0.1	0.5	-0.2	-0.4	0.1	0.1	0.1	-0.0	0.1	0.7	-0.5	0.1	0.4
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	0.4	0.4	-0.6	-0.6	-0.6	-0.5	-0.6	-0.9	0.5	-0.5	0.8
Pavlov. Cond. change in total contacts	0.3	0.4	1.0	0.7	0.6	-0.7	-0.6	-0.4	-0.6	-0.4	-1.0	0.6	-0.3	0.5
Pavlov. Cond. index score	0.1	0.1	0.6	0.2	0.2	-0.3	-0.3	-0.3	-0.1	-0.3	-0.8	0.5	-0.4	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.7	0.3	0.3	-0.2	-0.3	-0.2	-0.1	-0.3	-0.8	0.5	-0.3	0.1
Pavlov. Cond. lever contacts	0.2	0.2	1.0	0.1	0.2	-0.1	-0.1	-0.3	0.1	-0.4	-1.0	0.8	-0.6	0.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.5	-0.1	-0.0	0.3	0.3	0.1	0.2	0.1	0.7	-0.0	0.1	-0.7
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.9	-1.4	-1.4	0.8	0.9	0.2	1.1	0.3	0.8	0.1	-0.1	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.6	0.1	0.1	-0.3	-0.3	-0.4	-0.1	-0.4	-0.8	0.5	-0.4	-0.1
Pavlov. Cond. response bias	0.1	0.1	0.6	-0.1	-0.1	-0.2	-0.2	-0.3	0.0	-0.3	-0.8	0.4	-0.3	0.0
Pavlov. Cond. lever latency	1.2	1.7	2.4	1.5	1.5	-1.3	-1.4	-1.4	-0.8	-1.4	-1.3	1.2	-1.4	1.1
Pavlov. Cond. magazine entry latency	0.6	0.8	1.2	0.8	0.7	-1.0	-1.0	-1.1	-1.1	-1.0	-1.0	0.9	-0.8	0.4
Pavlov. Cond. change in total contacts	0.1	0.2	0.7	0.1	0.0	0.0	-0.1	0.3	-0.6	0.4	0.2	-0.4	0.8	-0.4
Pavlov. Cond. index score	0.2	0.3	0.7	-0.6	-0.5	0.5	0.4	0.6	0.0	0.6	0.4	-0.5	0.8	-0.5
Pavlov. Cond. latency score	0.1	0.1	0.6	-0.3	-0.3	0.2	0.2	0.4	-0.2	0.5	0.3	-0.4	0.8	-0.4
Pavlov. Cond. lever contacts	1.0	1.5	2.4	-1.5	-1.6	1.3	1.3	1.3	0.8	1.2	1.1	-1.1	1.2	-0.9
Pavlov. Cond. magazine entry number	0.0	0.0	0.2	0.0	-0.1	0.1	0.2	0.2	0.3	0.1	0.3	-0.2	-0.1	0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.5	1.0	-0.6	-0.6	0.7	0.6	0.7	1.0	0.5	0.9	-1.0	0.2	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	-0.5	-0.5	0.4	0.3	0.6	-0.1	0.6	0.5	-0.6	0.9	-0.6
Pavlov. Cond. response bias	0.4	0.5	1.1	-1.0	-1.0	0.8	0.8	0.7	0.3	0.7	0.5	-0.6	0.7	-0.5
Time in closed arm before self-admin	2.3	4.0	6.3	-2.2	-2.4	1.7	1.9	1.8	1.8	1.6	2.4	-1.9	1.4	-2.5
Time in closed arm after self-admin	0.3	0.3	0.6	0.6	0.5	-0.6	-0.6	-0.4	-0.7	-0.5	-0.7	0.8	-0.4	0.4
Time in open arm before self-admin	1.1	1.3	3.2	1.5	1.5	-1.0	-1.2	-0.6	-1.3	-0.3	-1.4	0.5	-0.1	1.8
Time in open arm after self-admin	0.9	1.0	2.0	0.9	0.9	-0.9	-0.9	-1.2	-0.7	-1.2	-0.9	1.0	-1.4	0.7
Bone: periosteal estimation	0.1	0.2	0.6	0.4	0.5	-0.1	-0.1	0.2	-0.8	0.3	-0.2	-0.3	0.5	0.6
Bone: periosteal perimeter	0.1	0.3	0.7	-0.0	0.1	0.4	0.4	0.7	-0.1	0.7	0.4	-0.8	0.8	-0.1
Bone: post-yield work	1.4	2.4	3.1	1.6	1.8	-1.5	-1.4	-1.5	-1.4	-1.6	-1.5	1.4	-1.7	1.7
Progressive ratio test 1 active lever presses	1.5	2.7	3.6	1.6	1.5	-1.9	-1.7	-1.8	-1.9	-1.7	-1.6	1.6	-1.5	1.2
Progressive ratio test 1 breakpoint	1.4	2.3	3.2	1.5	1.4	-1.8	-1.6	-1.7	-1.8	-1.6	-1.4	1.5	-1.3	1.0
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.5	0.4	0.4	-0.5	-0.5	-0.6	-0.6	-0.5	-0.2	0.7	-0.3	-0.2
Progressive ratio test 2 active lever presses	0.5	0.7	1.3	0.8	0.7	-1.1	-1.0	-1.0	-1.1	-0.9	-0.6	0.7	-0.8	-0.1
Progressive ratio test 2 breakpoint	0.5	0.7	1.3	0.8	0.7	-1.1	-1.0	-1.0	-1.1	-0.9	-0.5	0.6	-0.7	-0.1
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.2	0.2	0.3	-0.2	-0.2	-0.1	-0.3	-0.1	0.1	-0.1	0.0	-0.4
Incentive Sensitization - Responses	0.1	0.2	0.4	0.3	0.2	-0.7	-0.5	-0.5	-0.6	-0.4	-0.3	0.4	-0.4	-0.1
Incentive Sensitization - Breakpoint	0.0	0.1	0.3	0.2	0.1	-0.5	-0.4	-0.4	-0.5	-0.3	-0.1	0.2	-0.3	-0.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.5	-0.1	-0.4	-0.3	-0.1	-0.2	-0.3	-0.1	-0.3	0.1	-0.1	0.7
Progressive ratio	0.2	0.5	1.4	-0.6	-0.6	0.7	0.6	0.9	0.5	0.8	0.6	-0.7	1.2	-0.6
Food seeking constrained by brief footshock	0.7	0.9	1.1	-0.9	-0.9	0.9	0.9	0.9	1.0	0.9	1.1	-0.9	1.0	-0.8
Seeking ratio, punishment vs. effort	0.1	0.2	0.7	0.2	0.2	-0.3	-0.2	-0.6	-0.1	-0.6	-0.2	0.5	-0.8	0.3
Retroperitoneal fat weight	0.2	0.7	1.4	1.2	1.1	-0.9	-1.0	-0.6	-1.2	-0.7	-0.5	0.4	-0.7	0.6
Reaction time number correct	0.1	0.2	1.1	-0.2	-0.3	-0.1	-0.0	-0.5	0.1	-0.6	-0.3	0.7	-1.0	-0.5
Reaction time mean minus median	0.0	0.1	0.3	0.3	0.3	-0.2	-0.3	-0.0	-0.3	0.0	0.3	-0.3	0.1	-0.5
Reaction time mean minus median AUC	0.1	0.5	1.4	0.1	0.1	0.3	0.1	0.7	-0.1	0.8	0.9	-1.1	1.2	-1.0
Reaction time num false alarms	0.1	0.2	0.9	-0.2	-0.2	0.1	0.1	-0.4	0.4	-0.5	-0.2	0.4	-1.0	-0.3
Reaction time num false alarms AUC	0.2	0.4	1.4	0.1	0.1	-0.3	-0.3	-0.8	0.1	-0.8	-0.5	0.8	-1.2	-0.1
Reaction time trials correct on left	0.1	0.2	1.1	-0.2	-0.3	-0.1	-0.0	-0.5	0.1	-0.6	-0.3	0.7	-1.0	-0.5
Reaction time trials on left	0.1	0.3	1.3	-0.2	-0.2	-0.2	-0.1	-0.5	0.0	-0.7	-0.3	0.8	-1.1	-0.4
Reaction time mean	0.8	1.7	3.2	1.8	1.7	-1.5	-1.5	-1.2	-1.5	-1.2	-1.0	0.8	-1.0	1.0
Reaction time mean AUC	1.3	3.1	4.9	2.2	2.2	-1.9	-2.0	-1.7	-1.9	-1.6	-1.5	1.3	-1.4	1.4
Median of all reaction times	2.5	3.9	6.0	2.4	2.4	-2.1	-2.1	-1.9	-2.0	-1.9	-1.8	1.6	-1.6	1.7
Reaction time omissions	1.1	1.8	3.0	1.6	1.7	-1.2	-1.3	-1.3	-1.0	-1.4	-1.3	1.2	-1.4	1.2
Reaction time false alarm rate	0.2	0.3	0.6	0.4	0.5	-0.4	-0.4	-0.7	-0.2	-0.6	-0.6	0.5	-0.8	0.5
Reaction time premature initiation rate	1.1	1.8	3.1	-1.7	-1.8	1.4	1.5	1.1	1.4	1.0	1.4	-1.1	0.6	-1.4
Reaction time premature initiations	0.7	2.0	3.9	-1.9	-2.0	1.5	1.6	1.0	1.6	0.9	1.4	-0.9	0.4	-1.6
Std. dev. reaction times	0.0	0.1	0.3	0.4	0.3	-0.2	-0.2	0.1	-0.2	0.1	0.4	-0.4	0.2	-0.5
Reaction time trials completed	0.1	0.3	1.3	-0.2	-0.2	-0.2	-0.1	-0.5	0.0	-0.7	-0.3	0.8	-1.1	-0.4
Reaction time trials AUC	0.1	0.2	1.1	-0.3	-0.3	-0.0	0.1	-0.4	0.2	-0.6	-0.2	0.7	-1.0	-0.5
Run reversals in cocaine runway, females	2.5	2.9	4.3	-1.7	-1.2	2.1	1.8	1.6	2.0	1.6	1.9	-1.2	1.6	-1.5
Run reversals in cocaine runway, males	1.5	1.6	3.1	1.5	1.3	-1.7	-1.6	-1.2	-1.8	-1.1	-1.1	0.9	-0.9	0.5
Latency to leave start box in cocaine runway	0.2	0.3	1.1	0.3	0.2	-0.3	-0.4	-0.4	-0.2	-0.5	-1.1	0.6	-0.9	0.7
Latency to leave start box in cocaine runway, F	0.2	0.2	0.7	0.3	0.2	-0.4	-0.5	-0.3	-0.4	-0.4	-0.8	0.3	-0.7	0.4
Latency to leave start box in cocaine runway, M	0.3	0.3	0.8	0.2	0.3	-0.3	-0.2	-0.6	-0.1	-0.6	-0.9	0.9	-0.8	0.7
Std. dev. time between licks in bursts	3.5	6.7	8.5	-2.3	-2.3	2.6	2.6	2.8	2.1	2.9	2.6	-2.9	2.8	-2.5
Total sessions with >9 infusions	1.0	1.2	1.9	1.2	1.1	-1.3	-1.2	-1.2	-1.4	-1.1	-0.9	0.9	-1.0	0.5
Short access day 1 total inactive lever presses	0.4	0.9	1.8	0.7	0.8	-0.8	-0.9	-1.3	-0.7	-1.1	-0.7	1.3	-1.0	-0.2
Short access day 10 total inactive lever presses	0.0	0.1	0.3	-0.1	0.2	0.5	0.3	0.2	0.5	0.2	0.1	-0.0	0.2	-0.1
Short access day 1 total infusions	1.8	3.5	4.5	1.9	1.8	-2.0	-1.9	-2.1	-1.9	-2.0	-1.9	1.8	-1.9	1.2
Short access day 10 total infusions	5.6	9.3	11.8	3.1	2.9	-3.4	-3.2	-3.3	-3.4	-3.2	-3.0	2.9	-2.9	1.9
Short access total infusions	3.5	4.9	6.5	2.2	2.0	-2.6	-2.3	-2.5	-2.4	-2.5	-2.1	2.1	-2.2	1.1
Short access day 1 locomotion	0.1	0.1	0.2	-0.2	-0.2	0.2	0.2	0.2	0.1	0.4	0.5	-0.3	0.4	-0.2
Short access day 10 total locomotion	0.5	2.0	2.5	1.6	1.4	-1.6	-1.5	-1.5	-1.5	-1.6	-1.1	1.4	-1.4	0.7
Short access total locomotion	0.9	1.4	1.9	1.4	1.2	-1.3	-1.3	-1.3	-1.3	-1.2	-0.8	1.2	-1.1	0.7
One hour access (0.3 mA shock)	0.6	0.7	1.2	0.8	0.8	-1.0	-0.8	-1.1	-0.9	-1.0	-0.4	0.7	-1.0	-0.1
Compulsive drug intake	0.3	0.4	0.6	-0.7	-0.7	0.6	0.5	0.6	0.5	0.7	0.6	-0.7	0.8	-0.4
One hour access (shock baseline)	0.4	1.1	1.6	1.1	1.1	-1.2	-1.0	-1.3	-1.1	-1.2	-0.8	1.0	-1.2	0.1
Social response proportion	0.1	0.2	0.5	-0.1	0.1	0.4	0.2	0.4	0.4	0.4	0.5	-0.7	0.5	0.6
Social responses	2.4	3.1	4.1	-1.9	-1.6	2.0	1.8	1.8	2.0	1.6	1.9	-1.9	1.3	-1.2
Social time	0.6	1.0	1.8	1.1	1.1	-0.9	-0.9	-1.0	-0.6	-1.1	-0.9	0.7	-1.1	1.3
Soleus weight	0.1	0.4	1.1	0.3	0.5	-0.4	-0.3	-0.7	-0.5	-0.8	-0.8	0.8	-1.1	-0.2
Bone: stiffness	0.1	0.2	1.1	0.5	0.8	-0.0	-0.2	0.2	-0.4	0.1	-0.7	-0.0	0.0	1.1
Tibialis anterior weight	0.0	0.1	0.2	-0.2	0.1	0.5	0.5	0.4	0.5	0.2	0.2	-0.4	-0.1	-0.4
Time to tail flick, vehicle, before self-admin	0.8	0.9	1.4	0.9	1.0	-0.9	-1.0	-1.2	-0.9	-1.1	-0.9	1.2	-1.1	0.1
Time to tail flick, vehicle, after self-admin	0.4	0.7	1.8	1.0	0.8	-0.9	-1.0	-0.7	-1.2	-0.5	-0.6	0.7	0.2	1.4
Time to tail flick, test, before self-admin	0.7	0.8	1.6	-1.1	-1.1	0.8	1.0	0.6	1.1	0.5	0.9	-0.5	0.2	-1.3
Time to tail flick, test, after self-admin	0.6	0.6	1.4	0.5	0.5	-0.5	-0.5	-0.9	-0.1	-0.8	-1.2	1.0	-0.9	1.2
Delta time to tail flick, vehicle, before/after SA	0.8	0.9	4.5	0.8	0.7	-0.8	-0.8	-0.6	-0.9	-0.5	-0.9	0.8	-0.1	2.1
Delta time to tail flick, test, before/after SA	0.9	1.1	3.0	1.1	1.3	-0.8	-0.9	-0.8	-0.7	-0.8	-1.4	0.9	-0.6	1.7
Tibia length	0.1	0.3	1.2	0.5	0.5	-0.4	-0.4	0.0	-0.7	0.2	-0.6	-0.2	0.6	1.1
Ambulatory time before self-admin	1.2	3.6	5.4	-2.0	-1.9	1.9	1.8	1.6	2.0	1.8	1.9	-1.7	1.7	-2.3
Ambulatory time after self-admin	0.7	1.2	3.0	-1.1	-1.2	0.8	0.9	0.8	0.8	0.8	1.5	-1.1	0.8	-1.7
Bone: tissue strength	0.7	0.8	1.3	1.0	1.0	-0.8	-0.8	-0.8	-0.8	-0.8	-0.8	0.8	-0.6	1.2
Total heroin consumption	0.2	0.2	0.6	-0.4	-0.3	0.2	0.3	-0.2	0.6	-0.4	-0.5	0.5	-0.8	0.6
Bone: trabecular number	1.0	1.9	3.6	-1.1	-1.2	1.2	1.3	1.6	0.9	1.5	1.4	-1.9	1.5	-1.2
Bone: trabecular spacing	0.9	1.4	2.6	0.9	1.0	-0.9	-1.0	-1.3	-0.6	-1.4	-1.2	1.5	-1.6	1.0
Bone: trabecular thickness	2.5	3.4	4.9	-1.8	-1.7	1.9	1.8	2.0	1.5	2.1	1.6	-2.0	2.2	-1.6
Bone: trabecular tissue density	0.4	0.6	1.3	-0.8	-0.8	0.9	0.8	0.7	1.1	0.6	0.6	-0.5	0.4	-1.1
Water consumed over 24 hours	0.1	0.1	0.6	-0.3	-0.2	0.0	-0.1	-0.4	0.2	-0.5	-0.3	0.3	-0.8	-0.4
Number of responses in last shaping day	0.5	0.7	1.1	0.9	1.0	-0.6	-0.7	-0.7	-0.7	-0.8	-0.9	0.7	-0.8	1.1