Hub : Genes

PCOLCE2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	PCOLCE2	0.16	0.07	1.3e-12	0.12	0.14	0.12	0.12	1.1e-11	1.3e-12	1.4e-11	3.4e-11
2	RMTg	gene expression	PCOLCE2	0.18	0.1	1.2e-03	0.11	0.1	0.1	0.12	6.6e-04	1.0e-03	1.1e-03	3.7e-04
3	Liver	gene expression	PCOLCE2	0.09	0.04	1.4e-09	0.08	0.07	0.06	0.06	2.4e-09	7.3e-08	7.9e-07	1.1e-07
4	pVTA	gene expression	PCOLCE2	0.08	0.05	7.5e-03	0	0.01	0.02	0	2.4e-01	8.6e-02	3.2e-02	2.0e-01
5	NAcc	gene expression	PCOLCE2	0.03	0.02	7.4e-03	0.02	0.02	0.01	0.02	2.3e-03	2.6e-03	1.4e-02	1.3e-03
6	LHb	gene expression	PCOLCE2	0.35	0.14	4.1e-05	0.17	0.15	0.18	0.18	8.8e-05	2.6e-04	5.6e-05	5.4e-05
7	IL	gene expression	PCOLCE2	0.32	0.17	5.1e-04	0.08	0.04	0.03	0.08	4.9e-03	4.8e-02	7.5e-02	5.8e-03
8	Adipose	gene expression	PCOLCE2	0.03	0.02	8.2e-04	0.03	0.02	0.03	0.03	4.4e-04	1.3e-03	4.8e-04	6.4e-04
9	PL	gene expression	PCOLCE2	0.14	0.07	4.9e-14	0.13	0.13	0.12	0.13	2.8e-14	1.5e-14	5.1e-13	7.0e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bone: apparent density	1.1	1.9	3.2	-1.7	-1.1	1.2	1.4	-1.7	-1.1	-1.4	-1.8	0.2
Area under the delay curve	0.7	0.8	1.3	-1.0	-1.0	1.0	0.9	-1.1	-1.0	-0.9	-0.5	-0.1
BMI with tail	6.1	19.9	30.6	4.8	5.5	-5.5	-4.8	4.2	5.0	4.2	3.3	-0.9
BMI without tail	5.4	11.1	26.3	5.1	3.6	-3.2	-3.9	4.1	3.3	1.8	0.9	1.9
Body weight	3.9	16.4	29.2	3.8	5.0	-5.4	-4.1	3.3	5.2	3.9	2.7	-1.2
Weight adjusted by age	1.1	1.3	4.0	0.3	1.8	-2.0	-1.1	0.3	1.6	-0.1	0.3	-0.4
Bone surface	1.8	3.2	5.2	-2.3	-1.9	1.8	2.1	-2.1	-1.6	-1.3	-1.8	-0.2
Bone volume	1.1	1.9	2.8	-1.7	-1.3	1.4	1.5	-1.7	-1.2	-1.2	-1.6	0.0
Breakpoint value in progressive ratio session	0.9	1.0	2.2	-1.5	-1.0	0.6	1.1	-1.2	-0.9	-1.0	-0.6	-0.2
Number of licking bursts	0.1	0.2	0.4	-0.6	-0.6	0.5	0.4	-0.3	-0.3	-0.5	-0.1	-0.1
Context. condit. distance diff. score	0.3	0.4	1.6	-0.7	0.0	-0.2	0.1	-0.4	0.2	0.9	0.3	-1.3
Locomotion velocity, session 1	3.4	3.7	6.5	2.5	2.0	-1.9	-2.2	2.3	1.9	1.9	1.3	0.0
Locomotion distance, session 1	6.1	7.8	10.9	3.3	3.2	-3.0	-3.1	3.1	2.8	2.8	2.2	-0.5
Locomotion velocity, session 2	7.2	8.5	11.2	3.1	2.9	-2.8	-3.1	3.3	2.8	3.1	3.2	-1.2
Locomotion distance, session 2	7.8	11.0	15.8	4.0	3.7	-3.3	-3.8	3.9	3.2	3.2	2.7	-0.6
Locomotion velocity, session 3	1.0	1.2	3.0	1.4	1.1	-0.6	-1.4	1.7	0.7	1.1	0.9	-0.3
Locomotion distance, session 3	0.1	0.1	0.3	-0.3	0.1	-0.1	-0.0	-0.2	0.2	0.3	0.3	-0.6
Stereotopy head waving bouts, day 3	0.4	0.4	2.8	-0.6	-0.4	0.4	0.4	-0.2	-0.3	-0.0	-1.7	-0.2
Stereotopy head waving duration, day 3	0.3	0.4	1.0	0.8	0.6	-0.4	-0.7	1.0	0.4	0.5	-0.7	0.2
Locomotion velocity, session 7	3.9	4.3	7.1	2.7	2.5	-2.1	-2.6	2.5	2.0	1.6	1.1	0.1
Locomotion distance, session 7	0.4	0.5	1.1	1.0	0.9	-0.9	-0.8	0.8	0.8	0.2	0.2	0.5
Stereotopy head waving bouts, day 7	0.9	1.0	2.2	-1.1	-1.2	1.4	0.9	-0.4	-1.5	0.0	-0.8	-0.5
Stereotopy head waving duration, day 7	0.9	1.1	2.5	-0.8	-1.4	1.6	1.0	-0.4	-1.6	-0.3	-1.0	-0.0
Locomotion velocity, session 8	4.5	5.4	9.2	2.8	2.3	-1.8	-2.6	3.0	1.9	2.4	2.3	-0.7
Locomotion distance, session 8	2.7	3.9	5.9	1.9	2.1	-1.9	-2.1	2.0	1.8	2.4	2.0	-1.3
Degree of sensitization distance	0.4	0.4	1.1	1.0	0.6	-0.7	-0.6	0.6	0.4	-0.2	-0.2	0.9
Degree of sensitization stereotypy	0.5	0.5	1.7	-0.9	-0.6	0.7	0.4	-0.2	-0.7	0.7	0.4	-1.3
Conditioned locomotion	0.6	0.7	1.8	1.1	-0.3	0.7	-0.2	0.8	-0.8	-0.8	0.6	1.3
Cocaine response after cond. corrected	0.7	0.8	2.3	1.5	0.8	-0.6	-1.2	1.3	0.6	0.5	0.3	0.6
Cocaine response after cond. not corrected	1.0	1.1	3.0	1.7	0.9	-0.8	-1.2	1.5	0.8	0.6	0.0	0.8
Cocaine response before conditioning	0.2	0.2	0.6	0.6	0.2	-0.4	-0.2	0.4	0.2	0.2	-0.8	0.6
Saline control response	2.2	2.9	4.2	1.6	2.0	-2.0	-1.8	1.7	2.0	1.4	1.6	-0.6
Bone: connectivity density	1.2	1.8	2.4	-1.4	-1.4	1.6	1.4	-1.3	-1.5	-1.4	-1.3	0.3
Bone: cortical apparent density	0.4	0.5	2.9	0.6	0.3	-0.1	-0.4	1.1	0.0	0.2	1.7	0.2
Bone: cortical area	2.1	3.2	5.3	0.7	2.0	-1.9	-1.7	1.3	1.9	2.3	1.8	-2.0
Bone: cortical porosity	0.5	0.5	1.2	-0.0	0.7	-0.9	-0.5	0.2	0.9	0.7	0.7	-1.1
Bone: cortical porosity	0.6	0.7	1.5	0.0	0.8	-0.9	-0.6	0.3	0.8	0.8	1.1	-1.2
Bone: cortical thickness	1.2	2.0	3.3	0.7	1.4	-1.3	-1.4	1.3	1.3	1.8	1.6	-1.5
Bone: cortical thickness	0.1	0.1	0.5	-0.5	0.2	-0.1	0.2	-0.7	0.1	-0.2	0.1	-0.4
Bone: cortical tissue density	0.4	0.6	3.1	0.6	0.3	-0.1	-0.4	1.1	0.0	0.2	1.8	0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.7	-0.8	0.2	-0.4	0.1	-0.3	0.3	-0.1	-0.8	-0.5
Condit. Reinf. active-inactive response ratio	1.8	1.9	4.2	0.4	1.8	-2.1	-1.3	0.8	1.9	1.4	-0.1	-1.2
Condit. Reinf. active responses	0.1	0.1	0.7	-0.2	0.0	0.0	0.0	0.1	-0.1	-0.4	-0.8	0.2
Condit. Reinf. inactive responses	1.3	1.5	2.7	-0.3	-1.3	1.6	1.0	-0.6	-1.5	-1.5	-0.9	1.4
Incentive salience index mean	0.4	0.5	1.3	-0.5	0.9	-1.0	-0.5	0.2	0.8	0.7	0.0	-1.1
Condit. Reinf. lever presses	2.1	2.8	3.7	1.3	1.9	-1.8	-1.7	1.7	1.7	1.9	1.6	-1.2
Condit. Reinf. active minus inactive responses	0.7	0.8	3.5	-0.6	-0.2	0.3	0.5	-0.7	-0.3	-1.3	-1.9	0.9
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.1	0.9	1.0	-0.9	-0.8	0.6	1.1	-0.5	-0.8	1.1
Condit. Reinf. active responses	1.2	1.7	5.4	-1.1	-0.9	1.1	1.1	-1.1	-1.1	-1.5	-2.3	0.8
Condit. Reinf. inactive responses	1.3	1.6	2.9	-1.2	-1.3	1.5	1.2	-1.1	-1.6	-0.9	-1.7	0.3
Condit. Reinf. lever presses	0.7	0.9	3.1	-1.5	-0.3	0.2	0.8	-1.2	-0.2	-0.6	-1.8	-0.3
Condit. Reinf. lever reinforcers received	1.1	1.6	5.2	-1.3	-0.8	0.9	1.1	-1.2	-0.9	-1.5	-2.3	0.6
Conditioned reinforcement - actives	0.1	0.1	0.5	-0.0	-0.3	0.2	0.1	-0.4	-0.0	0.2	-0.7	0.2
Conditioned reinforcement - inactives	0.2	0.2	0.9	1.0	0.0	-0.1	-0.5	0.5	0.1	0.7	0.1	0.3
Conditioned locomotion	0.2	0.3	0.9	0.4	0.4	-0.6	-1.0	0.1	0.8	-0.1	-0.0	-0.3
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.5	0.3	-0.3	-0.2	0.6	0.2	0.5	0.7	-0.1
Patch foraging indifference point AUC	0.2	0.3	1.4	0.7	0.2	0.1	-0.2	0.4	-0.2	0.4	1.2	0.4
Delay disc. indifference point, 0s delay	1.7	1.9	2.6	-1.4	-1.4	1.6	1.4	-1.3	-1.6	-1.5	-1.3	0.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.5	-0.5	0.2	-0.3	0.1	-0.3	0.0	-0.1	-0.1	-0.7
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.3	0.2	0.0	-0.5	0.2	0.4	0.3	-0.1	-0.3
Delay disc. indifference point, 24s delay	0.3	0.3	0.8	-0.7	-0.5	0.3	0.7	-0.9	-0.5	-0.7	0.3	-0.2
Delay disc. indifference point, 4s delay	1.0	1.1	2.5	0.2	-1.2	1.6	0.6	-0.2	-1.5	-0.9	-0.9	1.0
Delay disc. indifference point, 8s delay	1.3	1.4	3.5	-1.8	-1.1	0.9	1.3	-1.9	-0.9	-0.8	-0.2	-0.7
Indifference point function ln k	0.3	0.5	2.4	-0.8	-0.2	-0.1	0.5	-0.7	0.2	-0.4	-1.5	0.0
Indifference point function log k	0.3	0.5	2.4	-0.8	-0.2	-0.1	0.5	-0.7	0.2	-0.4	-1.5	0.0
Patch foraging total patch changes 0 sec	0.2	0.4	0.8	0.6	0.6	-0.6	-0.4	0.7	0.5	0.8	0.9	-0.3
Patch foraging total patch changes 12 sec	0.7	0.9	3.1	0.7	0.9	-0.7	-0.7	1.0	0.4	1.0	1.8	-0.5
Patch foraging total patch changes 18 sec	0.1	0.2	1.2	0.4	0.2	-0.0	0.1	0.1	-0.0	0.5	1.1	0.1
Patch foraging total patch changes 24 sec	0.1	0.2	0.4	-0.2	-0.2	0.1	0.6	-0.7	-0.5	0.2	0.5	0.2
Patch foraging total patch changes 6 sec	0.1	0.1	0.4	0.6	0.1	0.2	-0.1	0.5	-0.4	0.2	0.4	0.4
Patch foraging time to switch 0 sec	0.9	1.4	3.2	-0.7	-1.5	1.7	1.2	-0.7	-1.8	-1.3	0.0	0.6
Patch foraging water rate 0 sec	0.6	1.0	1.9	1.0	1.3	-1.4	-1.0	0.6	1.3	0.8	-0.7	0.2
Patch foraging water rate 12 sec	0.4	0.7	1.8	0.5	1.0	-1.1	-0.8	0.4	1.4	0.9	0.0	-0.4
Patch foraging water rate 18 sec	2.3	3.1	6.0	1.7	2.1	-2.2	-2.0	1.5	2.5	1.7	0.4	-0.4
Patch foraging water rate 24 sec	0.1	0.2	0.4	0.0	0.5	-0.5	-0.4	0.0	0.6	-0.2	-0.6	-0.0
Patch foraging water rate 6 sec	0.6	0.9	1.9	0.5	1.1	-1.4	-1.0	0.4	1.4	1.0	-0.5	-0.6
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.9	-0.4	-0.4	0.5	0.6	-0.2	-1.0	-0.1	0.7	-0.3
Distance traveled before self-admin	2.5	2.6	3.3	1.6	1.7	-1.8	-1.8	1.7	1.8	1.6	1.7	-0.7
Distance traveled after self-admin	0.2	0.3	1.6	-0.3	0.1	-0.1	0.3	-0.7	0.2	-0.2	1.3	-0.3
Extensor digitorum longus weight	3.2	12.7	18.1	3.1	3.8	-3.8	-3.8	3.7	3.9	4.3	3.2	-2.0
Bone: elastic displacement	1.9	2.1	3.4	0.7	1.8	-1.8	-1.4	0.8	1.7	1.3	1.8	-1.2
Bone: elastic work	0.9	1.1	2.6	0.3	1.6	-1.6	-1.1	0.4	1.4	0.7	0.7	-0.8
Bone: endosteal estimation	0.4	0.9	1.5	0.9	1.2	-1.1	-1.1	1.1	1.2	0.8	0.3	-0.3
Bone: endosteal perimeter	1.5	3.2	4.4	0.9	2.0	-2.1	-1.8	1.4	2.1	2.1	1.6	-1.8
Epididymis fat weight	1.0	2.3	4.0	2.0	1.7	-1.6	-1.8	1.8	1.8	1.0	1.0	0.3
Delta time in closed arm before/after self-admin	0.5	0.5	2.0	-0.9	-0.0	0.3	-0.1	0.1	-0.4	-0.2	1.1	-1.4
Delta time in open arm before/after self-admin	0.4	0.4	1.1	1.0	-0.3	0.3	0.0	0.7	-0.5	0.6	0.6	1.0
Diff in mean of infusions in LGA sessions	0.8	0.8	1.8	-1.2	-0.7	0.3	1.0	-1.3	-0.7	-0.4	-1.3	-0.3
Delay discount exponential model param	0.6	0.6	1.1	0.7	1.0	-1.1	-0.8	1.0	0.9	0.8	0.4	-0.0
Extinction: sum of active levers before priming	0.2	0.2	0.7	-0.6	0.5	-0.8	0.2	-0.0	0.1	-0.2	0.4	-0.5
Active lever presses in extinction session 6	0.4	0.4	1.9	0.1	0.3	-0.6	-0.1	0.6	0.3	0.8	1.4	-0.4
Bone: final force	0.1	0.1	0.3	-0.1	0.5	-0.4	-0.3	-0.1	0.5	-0.2	-0.3	-0.1
Bone: final moment	0.1	0.2	0.5	-0.1	0.7	-0.6	-0.3	-0.1	0.7	-0.2	-0.3	-0.0
Food consumed during 24 hour testing period	0.7	0.9	1.6	-0.9	-0.9	0.9	1.1	-0.9	-0.8	-0.9	-1.3	0.5
Glucose	0.5	0.8	1.9	1.0	1.0	-0.7	-1.0	1.4	0.5	1.0	0.8	-0.3
Heart weight	0.6	0.9	2.0	-0.8	0.9	-1.3	-0.2	-0.7	1.4	0.5	0.5	-1.4
Delay discount hyperbolic model param	0.4	0.5	0.9	0.5	0.9	-1.0	-0.6	0.8	0.8	0.7	0.5	-0.0
Intermittent access intake day 1-15 change	0.1	0.1	0.8	0.1	0.0	-0.2	0.3	0.0	0.1	0.9	0.3	-0.1
Intermittent access intake escalation	0.1	0.1	0.8	0.2	0.2	-0.4	0.1	0.1	0.2	0.9	0.4	-0.1
Intermittent access intake escalation 2	0.5	0.5	1.1	-0.8	-0.8	0.6	1.0	-0.5	-0.7	0.7	0.1	-0.4
Intermitt. access day 1 inactive lever presses	1.3	1.4	3.1	1.3	1.1	-0.9	-1.4	1.2	1.0	1.2	1.8	-0.6
Intermitt. access day 15 inactive lever presses	0.3	0.4	1.8	-0.3	0.4	-0.4	-0.5	-0.1	0.4	0.5	0.5	-1.4
Intermitt. access escalation Index	0.5	0.4	1.6	0.7	-0.3	0.5	-0.1	0.6	-0.2	0.2	-1.3	1.0
Intermittent access day 1 total infusions	0.3	0.4	1.2	0.7	0.3	-0.3	-1.1	0.6	0.8	0.6	-0.2	-0.3
Intermittent access day 15 total infusions	0.6	0.6	1.1	1.0	0.6	-0.5	-1.0	0.8	0.8	1.0	-0.6	0.1
Intermittent access terminal intake (last 3 days)	0.4	0.5	1.7	0.4	0.4	-0.5	-0.7	0.3	0.9	1.3	-0.5	-0.6
Intermittent access total infusions	0.3	0.4	0.9	0.7	0.3	-0.3	-0.9	0.6	0.8	0.8	-0.2	-0.3
Intermittent access day 1 locomotion	0.5	0.5	1.6	0.8	0.6	-0.4	-1.3	0.7	0.8	0.4	0.5	-0.3
Intermittent access day 15 total locomotion	0.4	0.4	0.9	0.6	0.5	-0.4	-1.0	0.7	0.6	0.5	0.7	-0.5
Intermittent access total locomotion	0.6	0.7	1.3	0.8	0.5	-0.5	-1.1	0.9	0.8	0.8	1.0	-0.6
Intermittent access standard deviation	0.2	0.2	1.0	-0.6	0.4	-0.4	-0.3	0.2	-0.0	0.2	-0.1	-1.0
Left kidney weight	4.3	12.1	16.0	3.3	3.9	-4.0	-3.9	3.4	3.9	3.5	3.1	-1.5
Right kidney weight	4.3	12.0	15.2	3.3	3.7	-3.9	-3.6	3.4	3.8	3.7	3.6	-1.7
Cocaine induced anxiety	0.8	0.9	3.2	-1.8	-1.0	0.9	0.9	-0.9	-0.5	-0.1	-0.4	-1.0
Post-drug Anxiety	0.5	0.5	1.9	-1.4	-0.5	0.4	0.5	-0.9	0.1	-0.2	-0.8	-0.9
Baseline Anxiety	0.1	0.1	0.3	0.3	0.5	-0.6	-0.3	0.0	0.6	0.0	-0.0	0.1
Tail length	0.4	1.2	5.2	1.6	0.0	0.0	-0.4	0.7	0.5	-0.9	-1.2	2.3
Length with tail	0.1	0.2	0.8	-0.4	0.2	-0.7	0.2	-0.3	0.9	0.2	-0.3	-0.3
Length without tail	1.2	2.7	9.1	-2.0	0.9	-1.7	0.5	-1.3	1.2	1.6	1.1	-3.0
Times rat made contact with spout	0.7	0.8	3.6	-1.0	0.4	-0.5	-0.0	-0.0	0.6	1.0	0.7	-1.9
Lifetime Intake	0.2	0.2	0.6	0.6	0.1	-0.2	-0.8	0.3	0.8	0.7	-0.2	-0.2
Liver weight, left	0.4	0.7	2.1	1.2	0.6	-0.4	-0.8	1.4	0.6	0.9	0.6	-0.0
Liver weight, right	3.4	5.6	11.2	2.8	2.3	-2.1	-2.8	3.3	2.2	2.5	1.5	-0.5
Locomotor activity	0.6	1.0	2.0	1.4	1.2	-1.1	-0.8	1.0	1.2	0.5	-0.1	0.9
Locomotor testing distance	0.3	0.6	1.2	1.1	0.8	-0.8	-0.5	0.8	0.9	0.4	-0.2	0.8
Locomotor testing rearing	1.3	2.0	3.8	2.0	1.7	-1.3	-1.7	1.8	1.5	1.0	0.0	0.7
Locomotion in novel chamber	1.0	1.2	2.3	-0.9	-1.2	1.5	0.9	-0.7	-1.3	-1.2	-1.4	0.4
Locomotion in novel chamber post-restriction	1.0	1.2	4.7	-0.4	-1.2	1.2	0.9	-0.9	-0.7	-0.7	-2.2	0.9
Fecal boli incidents, locomotor time 1	1.3	1.5	3.0	1.7	1.2	-1.1	-1.5	1.5	1.2	1.2	0.5	0.1
Change in fecal boli incidents, locomotor task	0.3	0.3	0.8	0.9	0.8	-0.6	-0.5	0.3	0.5	0.2	0.1	0.5
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.7	0.2	0.6	-0.8	-0.5	0.2	0.7	0.9	1.3	-0.7
Bouts of movement, locomotor time 1	0.0	0.0	0.2	-0.2	-0.2	0.1	0.0	0.2	-0.0	0.2	-0.4	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.4	0.1	0.1	-0.1	-0.2	0.2	0.2	0.6	0.0	-0.4
Rest time, locomotor task time 1	1.9	2.1	5.0	-0.1	1.4	-1.6	-1.0	0.4	1.4	2.1	1.5	-2.2
Distance moved, locomotor task time 1	0.7	0.7	2.5	0.9	-0.3	0.8	-0.1	0.5	-0.6	-1.1	-0.8	1.6
Vertical activity count, locomotor time 1	0.6	0.7	1.4	-0.8	-1.0	1.2	0.6	-0.4	-0.8	-1.1	-0.7	0.3
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.6	-1.2	-0.5	0.2	0.6	-0.8	-0.1	0.6	0.3	-1.2
Bouts of movement, locomotor time 2	0.5	0.6	1.0	0.4	0.8	-0.6	-0.9	1.0	1.0	0.6	0.7	-0.5
Total resting periods, locomotor time 2	0.5	0.5	1.0	0.1	0.7	-0.6	-0.8	0.9	1.0	0.7	0.7	-0.7
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.2	0.3	-0.5	-0.1	0.1	0.3	0.3	0.5	-0.6
Distance moved, locomotor task time 2	0.6	0.7	1.7	-0.4	-0.9	1.3	0.5	-0.3	-1.1	-0.9	-0.9	0.5
Vertical activity count, locomotor time 2	0.8	0.9	2.0	-1.4	-1.0	1.2	0.8	-0.9	-0.7	-0.8	-0.9	-0.3
Light reinforcement 1	0.0	0.1	0.5	-0.1	-0.2	0.1	0.1	0.2	-0.4	0.1	-0.7	-0.1
Light reinforcement 2	0.2	0.2	0.8	-0.9	-0.1	-0.2	0.3	-0.7	-0.0	-0.2	-0.1	-0.8
Bone: marrow area	0.5	1.2	1.9	1.0	1.3	-1.3	-1.3	1.2	1.4	0.9	0.4	-0.4
Bone: maximum diameter	4.3	7.8	11.6	2.2	3.1	-3.0	-3.0	2.7	3.0	3.4	2.3	-2.1
Bone: maximum force	0.2	0.3	0.7	-0.1	0.6	-0.5	-0.6	0.2	0.8	0.5	0.5	-0.8
Bone: maximum moment	0.3	0.5	1.2	-0.0	0.8	-0.8	-0.7	0.3	1.1	0.5	0.5	-0.7
Mean time between licks in bursts	0.5	0.7	3.0	-1.2	0.2	-0.2	0.2	-0.6	0.3	0.7	0.7	-1.7
Mean num. licks in bursts	0.8	0.9	2.0	-0.1	1.1	-1.1	-0.6	0.3	1.0	1.3	0.9	-1.4
Cd content in liver	0.8	0.9	2.1	-1.5	-0.9	0.7	0.9	-0.9	-0.5	0.6	-0.1	-1.5
Co content in liver	0.4	0.5	0.9	0.1	0.7	-0.7	-0.8	0.7	0.6	0.8	0.8	-0.9
Cu content in liver	2.3	2.8	6.4	-2.5	-1.8	1.4	1.8	-2.0	-1.5	-1.1	-1.5	-0.7
Fe content in liver	1.8	2.1	4.9	-2.2	-1.3	0.9	1.7	-2.0	-1.0	-0.7	-1.9	-0.4
K content in liver	2.2	2.2	7.2	2.7	1.0	-0.6	-1.7	2.3	0.6	0.6	0.5	1.3
Mg content in liver	0.8	0.8	2.7	1.6	0.6	-0.4	-1.1	1.4	0.3	0.4	0.7	0.7
Mn content in liver	2.2	2.5	4.4	2.0	1.8	-1.5	-2.0	2.1	1.5	1.5	0.8	-0.2
Na content in liver	0.6	0.7	2.6	1.2	0.1	0.1	-0.6	0.9	-0.1	-0.8	-0.4	1.6
Rb content in liver	0.1	0.1	0.5	0.3	0.0	0.1	0.1	-0.2	-0.0	-0.5	-0.7	0.7
Se content in liver	1.5	1.8	3.8	-0.7	-1.5	1.4	1.2	-1.1	-1.3	-1.4	-1.9	1.3
Sr content in liver	0.3	0.3	0.7	0.1	-0.6	0.7	0.3	0.1	-0.7	-0.4	-0.8	0.6
Zn content in liver	0.1	0.1	0.3	0.5	0.1	-0.1	-0.2	-0.1	-0.0	-0.1	-0.2	0.5
Bone: minimum diameter	0.2	0.4	1.4	-0.9	0.3	-0.4	-0.0	-0.5	0.5	0.4	0.0	-1.2
Time in familiar zone, hab. session 1	5.4	5.1	6.3	-1.6	-2.5	2.4	2.5	-2.3	-2.3	-2.3	-2.4	1.8
Time in novel zone, hab. session 1	3.6	3.5	5.0	1.1	2.1	-2.2	-2.0	1.7	2.2	1.8	1.9	-1.5
Total zone transitions, hab. session 1	5.0	7.0	11.9	3.4	3.0	-2.5	-3.0	3.5	2.1	2.5	2.1	-0.1
Total locomotion distance, hab. session 1	3.5	5.0	9.6	3.1	2.5	-2.2	-2.6	3.0	1.8	1.7	1.5	0.5
Locomotion velocity, hab. session 1	4.5	6.3	12.5	3.5	2.9	-2.4	-2.9	3.3	1.9	1.9	1.9	0.5
Time in familiar zone, hab. session 2	0.7	0.7	2.5	-0.7	-0.7	0.7	0.8	-1.0	-0.4	-0.7	-1.6	0.6
Time in novel zone, hab. session 2	2.1	2.1	4.0	0.9	1.5	-1.6	-1.4	1.4	1.4	1.4	2.0	-1.2
Total zone transitions, hab. session 2	4.8	6.3	9.7	3.1	3.0	-2.5	-2.9	3.1	2.2	2.5	1.6	-0.3
Total locomotion distance, hab. session 2	3.2	4.2	9.2	3.0	2.4	-2.0	-2.3	2.6	1.7	1.6	1.0	0.7
Locomotion velocity, hab. session 2	3.3	4.4	9.9	3.1	2.4	-2.0	-2.4	2.7	1.6	1.6	1.1	0.7
Novel to familiar place preference ratio	0.0	0.0	0.1	-0.3	-0.2	-0.1	0.2	-0.2	-0.0	0.0	0.4	-0.2
Novelty place preference	0.1	0.1	0.2	-0.3	0.0	-0.3	0.1	-0.2	0.3	0.1	0.4	-0.4
Time in novel zone, NPP test	0.2	0.2	0.5	-0.3	0.3	-0.7	-0.1	-0.1	0.6	0.4	0.6	-0.6
Total zone transitions, NPP test	9.7	13.8	18.8	4.1	4.3	-4.0	-4.0	4.1	3.7	3.9	3.0	-1.0
Total locomotion distance, NPP test	7.1	9.8	17.0	4.1	3.6	-3.2	-3.5	4.0	2.8	2.8	1.8	0.2
Locomotion velocity, NPP test	5.6	8.0	15.3	3.9	3.2	-2.8	-3.2	3.7	2.3	2.4	1.7	0.4
Intraocular pressure	0.8	1.1	1.8	1.1	1.1	-1.1	-1.0	1.0	1.3	1.3	0.7	-0.0
Delta distance traveled before/after self-admin	1.8	1.9	3.4	-1.5	-1.4	1.5	1.8	-1.9	-1.5	-1.2	0.2	0.3
Delta ambulatory time before/after self-admin	1.0	1.1	1.7	-0.8	-1.1	1.3	1.3	-1.2	-1.3	-1.0	0.3	0.5
Parametrial fat weight	0.1	0.2	0.5	-0.0	-0.6	0.7	0.3	0.1	-0.7	-0.2	0.1	0.3
Pavlov. Cond. lever latency	0.9	1.1	1.7	-0.3	-1.3	1.1	0.9	-0.5	-1.1	-1.2	-1.2	1.2
Pavlov. Cond. magazine entry latency	1.5	1.9	3.5	-0.1	1.7	-1.7	-1.4	0.6	1.7	1.3	1.1	-1.9
Pavlov. Cond. change in total contacts	0.5	0.5	1.6	-0.2	0.7	-0.7	-0.5	0.4	0.8	0.9	0.5	-1.3
Pavlov. Cond. index score	1.2	1.6	2.8	-0.1	1.6	-1.5	-1.1	0.5	1.5	1.2	1.2	-1.7
Pavlov. Cond. latency score	1.3	1.7	2.8	0.1	1.7	-1.6	-1.2	0.5	1.5	1.3	1.3	-1.6
Pavlov. Cond. lever contacts	0.9	1.1	1.7	0.2	1.3	-1.3	-0.9	0.4	1.2	1.1	1.2	-1.3
Pavlov. Cond. magazine entry number	0.8	1.0	2.9	0.7	-1.0	1.2	0.6	-0.0	-1.1	-0.7	-0.8	1.7
Pavlov. Cond. intertrial magazine entries	3.7	4.5	6.3	-2.0	-2.2	2.0	2.3	-2.2	-2.1	-2.3	-2.5	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	3.1	-0.2	1.3	-1.3	-1.0	0.4	1.3	1.2	1.1	-1.8
Pavlov. Cond. response bias	0.5	0.6	2.5	-0.9	0.6	-0.7	-0.3	-0.1	0.6	0.6	0.4	-1.6
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.2	-0.8	0.8	0.2	0.3	-0.7	0.1	0.8	0.1
Pavlov. Cond. magazine entry latency	1.0	1.1	2.6	-0.3	1.0	-1.3	-0.7	0.2	1.3	1.1	1.1	-1.6
Pavlov. Cond. change in total contacts	0.9	1.3	3.0	0.9	1.7	-1.7	-1.2	0.7	1.5	0.6	-0.2	-0.1
Pavlov. Cond. index score	0.3	0.3	0.7	-0.7	0.6	-0.9	-0.0	-0.5	0.7	0.2	-0.3	-0.7
Pavlov. Cond. latency score	0.3	0.4	1.0	-0.6	0.7	-1.0	-0.2	-0.4	0.8	0.3	-0.1	-0.8
Pavlov. Cond. lever contacts	0.2	0.3	0.7	-0.5	0.7	-0.8	-0.2	-0.4	0.7	0.3	-0.4	-0.6
Pavlov. Cond. magazine entry number	0.4	0.5	1.8	0.6	-0.6	0.8	0.3	0.0	-0.6	-0.8	-0.4	1.3
Pavlov. Cond. intertrial magazine entries	4.2	5.5	9.4	-1.7	-2.6	2.8	2.5	-1.9	-3.1	-2.6	-1.7	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.0	-0.6	0.8	-1.0	-0.2	-0.4	0.8	0.4	-0.1	-0.9
Pavlov. Cond. response bias	0.3	0.4	0.7	-0.5	0.7	-0.8	-0.4	-0.1	0.8	0.4	-0.5	-0.8
Time in closed arm before self-admin	0.7	0.8	3.5	1.5	0.1	-0.3	-0.2	0.2	0.5	0.0	-0.8	1.9
Time in closed arm after self-admin	0.5	0.5	1.0	0.9	0.6	-0.6	-1.0	0.7	0.9	0.4	0.5	-0.0
Time in open arm before self-admin	0.8	0.9	3.0	-1.7	-0.4	1.0	0.7	-1.0	-0.7	-1.1	-0.6	-0.6
Time in open arm after self-admin	0.9	1.0	2.7	-1.0	-1.1	1.4	1.2	-0.6	-1.6	-0.7	-0.2	0.3
Bone: periosteal estimation	1.3	2.7	3.9	1.1	2.0	-1.9	-1.8	1.5	2.0	1.8	1.1	-1.3
Bone: periosteal perimeter	2.5	4.1	5.8	0.9	2.3	-2.3	-2.1	1.5	2.4	2.4	1.8	-2.1
Bone: post-yield work	0.3	0.4	1.2	-1.1	-0.7	0.6	0.7	-0.7	-0.3	0.1	-0.1	-0.8
Progressive ratio test 1 active lever presses	0.2	0.2	0.5	0.7	0.3	-0.2	-0.6	0.3	0.4	0.6	0.1	0.2
Progressive ratio test 1 breakpoint	0.4	0.4	0.8	0.9	0.6	-0.5	-0.8	0.4	0.8	0.8	0.2	0.0
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.4	0.3	0.1	-0.1	-0.3	-0.2	0.3	0.2	0.6	-0.0
Progressive ratio test 2 active lever presses	0.2	0.2	0.6	-0.0	0.6	-0.8	-0.4	-0.3	0.7	0.4	-0.6	-0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.5	-0.1	0.3	-0.5	-0.2	-0.4	0.5	0.2	-0.7	0.0
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.8	-0.4	-0.5	0.4	0.4	-0.9	-0.4	-0.1	-0.4	0.1
Incentive Sensitization - Responses	0.4	0.4	1.7	-0.4	0.7	-0.8	-0.4	-0.1	0.7	0.1	-1.3	-0.4
Incentive Sensitization - Breakpoint	0.4	0.4	1.7	-0.4	0.7	-0.8	-0.3	-0.2	0.8	0.1	-1.3	-0.4
Sum of active levers in priming session hrs 5-6	1.0	1.0	2.7	0.1	1.1	-1.7	-0.8	0.7	1.4	0.7	0.7	-0.9
Progressive ratio	1.5	1.8	2.7	1.1	1.6	-1.4	-1.5	1.3	1.4	1.7	1.0	-0.7
Food seeking constrained by brief footshock	0.5	0.6	1.6	0.2	0.3	-0.4	-0.9	0.8	0.6	1.1	0.9	-1.2
Seeking ratio, punishment vs. effort	0.3	0.4	0.8	-0.7	-0.9	0.8	0.5	-0.3	-0.6	-0.6	-0.6	-0.3
Retroperitoneal fat weight	1.0	3.1	5.5	2.3	2.0	-2.0	-2.1	2.2	1.9	0.8	0.7	0.5
Reaction time number correct	0.3	0.4	1.0	1.0	0.5	-0.1	-0.7	0.9	0.4	-0.0	-0.3	0.8
Reaction time mean minus median	1.3	1.7	4.6	1.0	0.6	-0.9	-0.9	1.2	0.8	2.1	2.1	-1.1
Reaction time mean minus median AUC	1.9	2.4	4.8	1.5	1.1	-1.2	-1.5	1.7	1.3	2.2	2.2	-0.9
Reaction time num false alarms	1.1	1.5	2.5	-1.1	-1.3	1.4	1.6	-1.2	-1.3	-0.9	-1.4	0.6
Reaction time num false alarms AUC	1.4	1.9	3.4	-1.2	-1.7	1.8	1.8	-1.2	-1.6	-0.8	-1.1	0.4
Reaction time trials correct on left	0.3	0.4	1.0	1.0	0.5	-0.1	-0.7	0.9	0.4	-0.0	-0.3	0.8
Reaction time trials on left	0.3	0.4	1.0	1.0	0.5	-0.1	-0.7	0.9	0.4	-0.0	-0.3	0.8
Reaction time mean	0.7	1.0	3.6	-0.4	-0.2	0.1	0.2	0.2	-0.3	1.5	1.9	-1.6
Reaction time mean AUC	0.5	0.7	2.2	-0.5	-0.5	0.4	0.4	-0.1	-0.7	1.0	1.5	-1.2
Median of all reaction times	0.6	0.8	1.8	-1.0	-0.7	0.6	0.7	-0.3	-0.9	0.8	1.2	-1.3
Reaction time omissions	0.1	0.1	0.5	0.4	0.1	0.0	-0.1	-0.0	-0.2	0.2	0.7	0.3
Reaction time false alarm rate	1.3	1.8	3.4	-1.4	-1.6	1.5	1.9	-1.4	-1.5	-0.7	-1.0	0.1
Reaction time premature initiation rate	0.3	0.4	1.8	-0.3	-0.5	0.5	0.4	-0.9	-0.7	-0.1	-1.3	0.2
Reaction time premature initiations	0.2	0.2	1.5	0.4	-0.1	0.2	-0.1	-0.2	-0.2	-0.1	-1.2	0.6
Std. dev. reaction times	0.6	0.9	3.6	0.4	0.1	-0.3	-0.2	0.6	0.0	1.7	1.9	-1.1
Reaction time trials completed	0.3	0.4	1.0	1.0	0.5	-0.1	-0.7	0.9	0.4	-0.0	-0.3	0.8
Reaction time trials AUC	0.2	0.3	0.6	0.8	0.3	0.0	-0.5	0.8	0.2	-0.1	-0.4	0.7
Run reversals in cocaine runway, females	0.6	0.6	2.7	1.0	0.3	-0.1	-0.3	0.3	0.1	-1.0	-0.5	1.7
Run reversals in cocaine runway, males	1.2	1.2	5.2	-1.0	0.4	-0.7	-0.2	-0.2	0.8	1.4	0.8	-2.3
Latency to leave start box in cocaine runway	2.5	2.7	4.0	-1.9	-1.8	1.8	1.8	-1.5	-1.9	-2.0	-0.8	0.4
Latency to leave start box in cocaine runway, F	1.3	1.4	2.9	-0.7	-1.2	1.3	1.3	-0.8	-1.4	-1.7	-0.6	1.3
Latency to leave start box in cocaine runway, M	1.8	1.7	3.4	-1.9	-1.5	1.5	1.2	-1.3	-1.4	-1.2	-0.9	-0.5
Std. dev. time between licks in bursts	0.0	0.0	0.2	0.0	0.0	0.4	-0.1	0.1	-0.2	-0.0	-0.2	0.0
Total sessions with >9 infusions	0.1	0.1	0.3	0.4	-0.0	-0.2	-0.3	0.1	0.5	0.5	0.2	-0.0
Short access day 1 total inactive lever presses	0.6	0.7	2.1	1.4	0.1	0.5	-0.9	1.0	-0.1	0.6	1.2	0.4
Short access day 10 total inactive lever presses	1.7	1.9	4.6	0.9	1.1	-0.9	-1.2	1.7	0.8	1.8	2.1	-1.1
Short access day 1 total infusions	0.4	0.5	1.5	1.2	0.1	0.2	-0.9	0.9	0.5	0.7	0.1	0.4
Short access day 10 total infusions	0.5	0.5	1.3	0.8	0.5	-0.6	-1.1	0.7	1.1	0.7	0.0	-0.2
Short access total infusions	0.3	0.3	1.0	1.0	0.0	0.1	-0.8	0.6	0.7	0.7	0.2	0.2
Short access day 1 locomotion	1.3	1.4	4.8	2.2	0.4	0.0	-1.0	1.8	0.1	-0.0	0.3	1.8
Short access day 10 total locomotion	2.2	2.4	8.3	0.8	1.3	-1.1	-1.4	1.5	1.0	1.6	2.9	-1.5
Short access total locomotion	1.2	1.2	2.5	1.5	1.0	-0.9	-1.3	1.2	1.1	0.6	1.6	0.1
One hour access (0.3 mA shock)	0.5	0.6	1.5	-0.3	-0.8	0.7	0.6	-0.7	-0.6	-0.6	-1.2	0.8
Compulsive drug intake	2.5	2.5	5.8	-0.2	-1.2	1.5	1.2	-0.8	-1.7	-2.4	-1.6	2.4
One hour access (shock baseline)	0.4	0.4	1.0	-1.0	-0.3	-0.0	0.3	-0.9	0.2	0.4	-0.9	-0.9
Social response proportion	0.7	0.8	1.7	-1.3	-0.9	0.7	1.0	-1.1	-0.8	-0.3	0.6	-0.8
Social responses	0.2	0.2	0.7	-0.8	-0.4	0.3	0.4	-0.2	-0.4	-0.3	0.3	-0.8
Social time	0.5	0.7	1.8	-1.2	-0.6	0.5	0.7	-0.3	-0.3	0.9	0.8	-1.3
Soleus weight	1.4	4.2	5.7	2.4	2.4	-2.2	-2.4	2.2	2.3	2.1	1.4	-0.3
Bone: stiffness	0.2	0.2	0.9	-0.9	-0.3	0.4	0.2	-0.2	-0.0	0.3	0.1	-1.0
Tibialis anterior weight	1.3	4.3	7.5	1.9	2.3	-2.5	-2.2	1.8	2.7	2.3	1.6	-0.6
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.8	0.8	0.2	-0.1	-0.2	0.9	-0.1	0.4	-0.5	0.7
Time to tail flick, vehicle, after self-admin	0.8	0.9	1.5	1.1	1.0	-0.9	-1.1	1.2	1.0	0.7	0.8	0.1
Time to tail flick, test, before self-admin	0.4	0.4	1.7	-0.4	-0.7	0.9	0.2	-0.3	-0.6	-0.3	-1.3	0.1
Time to tail flick, test, after self-admin	0.2	0.2	0.6	0.2	0.8	-0.7	-0.5	-0.0	0.5	-0.2	-0.5	0.0
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.4	0.5	0.6	-0.6	-0.8	0.5	0.9	0.5	1.2	-0.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	0.7	0.6	-0.7	-0.3	-0.1	0.4	-0.2	0.0	0.6
Tibia length	0.3	0.7	1.4	0.9	1.0	-1.2	-0.7	0.6	1.2	0.6	0.8	0.0
Ambulatory time before self-admin	2.2	2.3	3.0	1.4	1.7	-1.7	-1.7	1.6	1.7	1.7	1.2	-0.7
Ambulatory time after self-admin	0.2	0.3	2.1	0.0	0.2	-0.1	0.0	-0.2	0.2	0.1	1.5	-0.3
Bone: tissue strength	0.1	0.1	0.2	0.1	-0.0	-0.1	-0.1	0.4	0.2	0.1	-0.5	0.2
Total heroin consumption	1.1	1.3	4.6	-2.1	-0.1	-0.4	0.8	-1.8	0.3	-0.7	-1.0	-1.3
Bone: trabecular number	1.7	2.6	4.3	-2.1	-1.5	1.7	1.8	-1.8	-1.6	-1.5	-1.5	-0.0
Bone: trabecular spacing	0.5	0.6	2.2	1.5	0.5	-0.4	-0.8	1.0	0.4	0.3	0.8	0.6
Bone: trabecular thickness	0.4	0.5	1.7	0.9	0.7	-0.5	-0.5	0.2	0.6	-0.6	-0.7	1.3
Bone: trabecular tissue density	1.6	2.2	3.2	1.7	1.7	-1.7	-1.7	1.6	1.8	1.3	1.1	-0.0
Water consumed over 24 hours	0.3	0.4	1.4	-0.9	-0.3	0.4	0.6	-0.5	-0.3	-0.6	-1.2	-0.1
Number of responses in last shaping day	0.7	0.7	2.1	1.5	0.5	-0.4	-0.8	1.0	0.4	1.0	1.0	0.3