Hub : Genes

PCOLCE2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression PCOLCE2 0.2 0.07 1.2e-13 0.21 0.16 0.21 0.2 1.5e-16 3.1e-13 1.1e-16 6.6e-16
2 Brain gene expression PCOLCE2 0.16 0.06 3.0e-12 0.12 0.13 0.12 0.11 2.4e-11 2.3e-12 2.0e-11 9.5e-11
3 RMTg gene expression PCOLCE2 0.18 0.09 1.4e-03 0.12 0.08 0.09 0.12 3.8e-04 3.8e-03 2.1e-03 5.8e-04
4 Liver gene expression PCOLCE2 0.1 0.05 2.7e-10 0.09 0.07 0.06 0.07 6.5e-10 1.5e-08 2.3e-07 2.3e-08
5 NAcc gene expression PCOLCE2 0.03 0.02 8.5e-03 0.01 0.01 0.01 0 4.1e-02 2.2e-02 1.1e-02 1.2e-01
6 LHb gene expression PCOLCE2 0.34 0.14 6.8e-05 0.17 0.15 0.17 0.17 6.2e-05 2.6e-04 9.6e-05 8.1e-05
7 Adipose gene expression PCOLCE2 0.04 0.02 1.7e-04 0.03 0.03 0.04 0.03 2.7e-04 2.2e-04 5.4e-05 6.2e-04
8 IL gene expression PCOLCE2 0.34 0.18 5.0e-04 0.09 0.03 -0 0.07 3.8e-03 5.9e-02 3.6e-01 7.7e-03
9 IC gene expression PCOLCE2 0.15 0.11 7.0e-03 0.06 0.01 0.04 0.04 1.6e-03 1.0e-01 8.9e-03 7.2e-03
10 NAcc intron excision ratio chr8_105073318_105074057 0.03 0.03 4.6e-03 0.01 0.01 0 0.01 2.3e-02 2.9e-02 8.0e-02 1.2e-02
11 PL gene expression PCOLCE2 0.14 0.07 4.4e-14 0.1 0.12 0.12 0.12 2.1e-11 5.7e-13 1.6e-12 8.4e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.22.13.2-1.6-1.5-1.1-1.4-1.6-1.71.81.5-1.5-1.10.5
Area under the delay curve0.60.71.3-0.9-1.0-0.8-0.9-1.0-1.10.70.8-0.3-0.3-0.3
BMI with tail7.224.936.75.95.16.15.94.95.5-5.0-5.23.54.7-1.4
BMI without tail4.714.224.54.94.94.34.14.74.4-2.8-3.02.92.60.6
Body weight2.812.424.14.02.64.94.72.34.3-3.4-3.60.44.3-1.6
Weight adjusted by age0.60.92.21.10.21.51.50.51.0-0.40.1-1.30.7-0.1
Bone surface1.93.56.0-2.1-2.3-1.9-2.0-2.4-2.22.11.5-1.6-1.1-0.1
Bone volume1.32.33.5-1.7-1.6-1.4-1.6-1.9-1.71.81.5-1.2-1.10.3
Breakpoint value in progressive ratio session0.20.30.9-0.4-0.8-0.30.0-0.7-0.10.20.8-0.9-0.2-0.1
Number of licking bursts0.20.30.4-0.5-0.6-0.6-0.6-0.6-0.70.30.3-0.6-0.3-0.0
Context. condit. distance diff. score0.20.31.7-0.0-0.80.20.1-0.40.1-0.2-0.40.10.7-1.3
Locomotion velocity, session 13.23.46.42.12.51.81.72.51.7-1.7-1.62.31.00.0
Locomotion distance, session 15.97.410.53.13.22.92.83.12.9-2.8-2.62.91.9-0.5
Locomotion velocity, session 26.57.611.23.03.02.72.72.72.8-3.3-2.93.32.1-1.1
Locomotion distance, session 27.510.515.33.83.93.43.23.73.2-3.3-3.23.62.2-0.6
Locomotion velocity, session 31.11.24.11.11.30.70.62.00.8-0.7-1.01.90.1-0.3
Locomotion distance, session 30.10.10.3-0.3-0.40.0-0.1-0.3-0.10.0-0.1-0.00.1-0.5
Stereotopy head waving bouts, day 30.30.41.60.1-0.6-0.4-0.4-0.1-0.31.2-0.2-1.30.3-0.2
Stereotopy head waving duration, day 30.40.51.71.00.90.40.51.30.60.2-0.70.30.30.3
Locomotion velocity, session 74.34.78.42.82.82.22.22.92.4-1.7-1.62.51.20.1
Locomotion distance, session 70.50.61.21.11.10.70.71.01.0-0.6-0.20.70.30.4
Stereotopy head waving bouts, day 71.01.11.9-1.4-1.4-1.3-1.4-0.7-1.31.2-0.0-0.2-0.6-0.8
Stereotopy head waving duration, day 70.91.12.3-1.3-0.9-1.4-1.5-0.4-1.31.40.50.0-1.20.1
Locomotion velocity, session 84.15.011.42.62.61.71.62.92.3-2.2-2.03.41.0-0.7
Locomotion distance, session 82.43.56.22.11.81.81.71.91.8-2.0-1.92.51.4-1.1
Degree of sensitization distance0.60.61.41.21.20.60.81.10.9-0.40.10.50.10.8
Degree of sensitization stereotypy0.40.51.7-0.9-1.0-0.6-0.6-0.4-0.60.1-0.60.30.0-1.3
Conditioned locomotion0.60.71.40.41.0-0.3-0.61.0-0.4-0.30.61.2-1.21.2
Cocaine response after cond. corrected0.60.72.31.11.40.20.51.50.6-0.5-0.41.10.00.6
Cocaine response after cond. not corrected0.70.92.61.21.60.30.71.50.8-0.4-0.50.90.20.8
Cocaine response before conditioning0.10.10.40.30.60.20.40.20.20.4-0.20.1-0.10.6
Saline control response1.82.43.91.51.31.81.91.52.0-1.9-1.51.01.4-0.8
Bone: connectivity density1.32.04.3-1.5-1.3-1.4-1.6-1.2-2.11.61.3-0.9-1.40.5
Bone: cortical apparent density0.30.42.5-0.00.40.40.40.50.2-1.6-0.50.7-0.0-0.2
Bone: cortical area1.82.74.31.30.62.01.80.72.0-2.0-2.10.62.1-1.9
Bone: cortical porosity0.30.41.00.1-0.10.70.80.21.0-0.6-0.30.10.7-1.0
Bone: cortical porosity0.60.61.60.2-0.00.80.90.31.0-1.0-0.60.40.9-1.3
Bone: cortical thickness1.01.73.20.80.61.51.40.81.7-1.8-1.70.51.3-1.3
Bone: cortical thickness0.10.20.4-0.4-0.50.3-0.0-0.60.6-0.00.4-0.70.1-0.2
Bone: cortical tissue density0.30.42.5-0.00.50.30.40.50.1-1.6-0.40.7-0.1-0.2
Condit. Reinf. active minus inactive responses0.40.43.1-0.2-0.90.20.3-0.40.00.40.0-1.80.5-0.6
Condit. Reinf. active-inactive response ratio1.81.94.11.40.42.02.00.71.4-0.8-1.4-0.92.0-1.2
Condit. Reinf. active responses0.10.20.8-0.3-0.3-0.3-0.10.20.00.60.5-0.9-0.40.2
Condit. Reinf. inactive responses1.51.84.3-1.2-0.4-1.8-1.7-0.2-1.01.31.70.1-2.11.5
Incentive salience index mean0.50.71.80.4-0.50.90.9-0.00.6-0.4-0.7-1.31.1-1.2
Condit. Reinf. lever presses1.82.63.91.81.21.91.81.31.9-1.8-2.00.81.6-1.2
Condit. Reinf. active minus inactive responses0.50.71.8-0.7-0.7-0.5-0.4-0.5-0.11.31.3-1.3-0.60.8
Condit. Reinf. active-inactive response ratio0.40.41.00.70.70.50.70.80.70.30.6-0.5-0.21.0
Condit. Reinf. active responses1.01.43.4-1.4-1.2-1.1-1.1-0.9-0.61.81.5-1.2-0.90.6
Condit. Reinf. inactive responses0.91.12.2-1.5-1.2-1.2-1.4-0.9-0.91.50.8-0.5-0.80.2
Condit. Reinf. lever presses0.81.13.5-0.9-1.6-0.4-0.4-1.4-0.31.30.9-1.90.0-0.4
Condit. Reinf. lever reinforcers received0.91.33.1-1.3-1.4-0.9-1.0-1.0-0.51.71.4-1.4-0.70.4
Conditioned reinforcement - actives0.20.31.3-0.4-0.3-0.7-0.7-0.3-0.41.20.1-0.3-0.30.4
Conditioned reinforcement - inactives0.20.31.20.50.80.20.30.60.4-0.1-0.81.10.30.0
Conditioned locomotion0.10.10.40.0-0.2-0.5-0.4-0.2-0.20.50.6-0.5-0.20.2
Patch foraging indifference point 0 sec0.10.20.60.30.60.30.20.50.4-0.6-0.40.80.30.0
Patch foraging indifference point AUC0.30.42.20.10.90.2-0.10.4-0.3-0.70.21.5-0.60.4
Delay disc. indifference point, 0s delay1.61.83.1-1.6-1.5-1.5-1.4-1.1-1.81.61.4-0.8-1.20.2
Delay disc. indifference point, 16s delay0.10.10.40.1-0.40.30.3-0.5-0.0-0.1-0.1-0.50.4-0.6
Delay disc. indifference point, 2s delay0.10.20.50.60.20.20.00.60.20.0-0.10.50.7-0.4
Delay disc. indifference point, 24s delay0.20.20.8-0.7-0.6-0.4-0.2-0.9-0.50.10.5-0.2-0.1-0.1
Delay disc. indifference point, 4s delay1.31.32.7-0.70.1-1.6-1.50.2-1.61.21.01.3-1.30.9
Delay disc. indifference point, 8s delay1.01.23.5-1.3-1.7-0.7-0.9-1.9-1.00.50.8-1.20.0-0.7
Indifference point function ln k0.20.42.4-0.0-0.70.20.3-0.60.40.80.0-1.60.7-0.1
Indifference point function log k0.20.42.4-0.0-0.70.20.3-0.60.40.80.0-1.60.7-0.1
Patch foraging total patch changes 0 sec0.20.30.60.40.60.60.40.50.6-0.7-0.60.80.5-0.2
Patch foraging total patch changes 12 sec0.30.41.50.30.60.50.40.70.1-1.0-0.31.2-0.0-0.3
Patch foraging total patch changes 18 sec0.10.21.0-0.10.40.2-0.2-0.2-0.1-0.60.31.0-0.20.3
Patch foraging total patch changes 24 sec0.20.31.0-1.0-0.4-0.2-0.5-0.7-0.90.10.50.1-0.50.4
Patch foraging total patch changes 6 sec0.20.31.0-0.00.6-0.2-0.50.4-0.5-0.00.31.0-0.90.7
Patch foraging time to switch 0 sec0.61.23.1-1.2-0.8-1.7-1.5-0.4-1.40.71.1-0.1-1.50.6
Patch foraging water rate 0 sec0.51.02.11.21.11.41.40.71.2-0.2-0.90.11.10.2
Patch foraging water rate 12 sec0.30.71.90.90.51.41.00.00.9-0.5-0.7-0.11.3-0.5
Patch foraging water rate 18 sec2.33.56.52.61.72.32.31.62.3-1.4-1.60.42.3-0.6
Patch foraging water rate 24 sec0.20.20.80.50.10.70.50.10.40.20.3-0.90.6-0.0
Patch foraging water rate 6 sec0.60.92.11.10.51.21.30.21.1-0.3-0.9-0.31.5-0.6
Seeking ratio, delayed vs. immediate footshock0.20.20.6-0.5-0.3-0.1-0.2-0.3-0.6-0.3-0.40.8-0.4-0.5
Distance traveled before self-admin1.01.32.91.01.21.11.11.21.3-1.7-1.01.21.0-0.6
Distance traveled after self-admin0.20.20.7-0.7-0.5-0.0-0.1-0.8-0.1-0.60.5-0.50.0-0.2
Extensor digitorum longus weight2.610.313.93.52.83.43.53.03.7-3.6-3.62.63.1-1.8
Bone: elastic displacement1.41.73.71.00.61.91.70.51.5-1.7-1.10.21.6-1.0
Bone: elastic work0.71.02.91.00.31.71.40.41.2-1.0-0.5-0.31.2-0.6
Bone: endosteal estimation0.30.61.71.30.70.80.80.70.8-0.4-0.60.80.8-0.4
Bone: endosteal perimeter1.22.64.81.90.81.71.80.81.5-1.7-2.00.92.2-1.7
Epididymis fat weight0.72.54.91.82.21.91.72.21.8-1.1-0.91.20.70.7
Delta time in closed arm before/after self-admin0.30.31.3-0.4-1.0-0.4-0.3-0.4-0.3-0.1-0.3-0.3-0.1-1.1
Delta time in open arm before/after self-admin0.70.73.3-0.60.9-0.5-0.50.9-0.6-0.30.11.8-1.10.9
Diff in mean of infusions in LGA sessions0.40.41.5-0.4-1.2-0.4-0.2-1.0-0.60.8-0.0-0.80.1-0.6
Delay discount exponential model param0.40.51.00.80.80.80.90.81.0-0.6-0.70.10.20.2
Extinction: sum of active levers before priming0.40.41.20.2-0.41.11.0-0.10.4-0.8-0.2-0.80.5-0.6
Active lever presses in extinction session 60.30.31.3-0.1-0.10.50.6-0.10.2-1.2-0.80.20.2-0.5
Bone: final force0.10.10.3-0.0-0.30.50.2-0.30.10.10.3-0.40.1-0.2
Bone: final moment0.10.10.60.1-0.20.80.4-0.20.30.00.4-0.60.2-0.1
Food consumed during 24 hour testing period0.60.81.7-1.0-1.0-0.9-1.0-1.0-0.51.30.9-0.9-0.70.4
Glucose0.91.42.61.41.51.31.11.41.6-1.0-0.81.20.40.3
Heart weight0.81.23.30.9-0.11.41.3-0.11.3-0.9-1.0-1.01.8-1.1
Delay discount hyperbolic model param0.40.40.90.70.60.80.90.61.0-0.7-0.7-0.10.30.0
Intermittent access intake day 1-15 change0.10.20.6-0.8-0.4-0.3-0.3-0.7-0.5-0.0-0.50.2-0.2-0.1
Intermittent access intake escalation0.10.20.8-0.9-0.3-0.3-0.3-0.6-0.6-0.0-0.50.3-0.40.1
Intermittent access intake escalation 21.31.43.7-1.9-1.6-1.3-1.3-1.7-1.50.6-0.1-0.7-0.5-0.4
Intermitt. access day 1 inactive lever presses0.20.92.31.21.20.70.71.00.5-1.1-1.11.50.4-0.3
Intermitt. access day 15 inactive lever presses0.20.41.4-0.6-1.0-0.7-0.5-0.7-0.50.3-0.3-0.20.3-1.2
Intermitt. access escalation Index0.50.72.0-0.30.7-0.8-0.90.6-0.81.10.60.8-1.01.4
Intermittent access day 1 total infusions0.20.41.21.10.60.10.21.10.9-0.1-0.2-0.00.5-0.2
Intermittent access day 15 total infusions0.20.31.10.60.70.00.11.10.50.2-0.70.30.20.2
Intermittent access terminal intake (last 3 days)0.20.20.70.40.1-0.00.10.40.60.1-0.8-0.30.7-0.4
Intermittent access total infusions0.40.41.11.00.50.20.41.01.0-0.3-0.5-0.00.8-0.5
Intermittent access day 1 locomotion0.91.12.61.61.30.70.81.61.2-1.1-0.90.70.8-0.3
Intermittent access day 15 total locomotion0.50.81.71.30.60.60.80.90.9-1.0-1.30.60.9-0.8
Intermittent access total locomotion0.81.01.81.30.90.60.91.21.1-1.1-1.20.31.0-0.7
Intermittent access standard deviation0.30.52.40.3-0.80.20.2-0.30.2-0.7-1.0-0.80.8-1.5
Left kidney weight2.511.817.04.13.14.14.12.53.8-3.9-3.51.93.9-1.7
Right kidney weight3.013.620.94.63.44.34.43.04.0-4.2-3.82.23.8-1.7
Cocaine induced anxiety0.60.92.4-1.6-1.2-0.9-1.0-1.1-0.40.90.2-1.2-0.0-0.3
Post-drug Anxiety0.40.41.0-0.7-0.8-0.8-0.9-0.5-0.11.00.2-0.90.1-0.3
Baseline Anxiety0.50.52.31.50.70.70.60.90.7-0.4-0.20.50.5-0.3
Tail length0.20.93.6-0.2-0.3-0.2-0.4-0.8-0.01.11.6-1.9-0.41.1
Length with tail0.20.94.3-0.3-1.10.60.4-1.30.40.1-0.0-2.11.0-0.7
Length without tail0.72.25.20.2-1.41.31.2-1.60.6-0.8-1.4-1.72.3-2.2
Times rat made contact with spout0.80.93.80.0-0.90.60.6-0.50.8-0.7-1.2-0.61.4-2.0
Lifetime Intake0.20.30.80.80.50.20.20.80.9-0.1-0.3-0.00.7-0.3
Liver weight, left1.52.53.91.81.51.51.51.12.0-1.9-1.91.51.5-0.9
Liver weight, right1.83.15.02.22.11.71.71.92.2-1.8-1.81.71.3-0.3
Locomotor activity0.71.12.31.21.51.31.00.91.4-0.5-0.30.70.61.0
Locomotor testing distance0.30.51.10.81.10.60.40.80.70.10.20.80.01.1
Locomotor testing rearing1.02.05.11.91.91.21.22.21.5-0.6-0.51.70.60.7
Locomotion in novel chamber1.62.03.6-1.4-1.2-1.8-1.9-0.8-1.41.71.7-1.0-1.50.8
Locomotion in novel chamber post-restriction0.50.83.2-0.5-0.2-1.1-1.1-0.4-0.91.80.4-0.4-0.71.0
Fecal boli incidents, locomotor time 10.60.92.40.91.50.80.91.60.5-0.3-1.01.20.40.2
Change in fecal boli incidents, locomotor task0.40.41.00.71.00.90.60.60.7-0.5-0.30.60.30.6
Time >=10cm from walls, locomotor time 10.40.51.30.60.30.60.80.40.7-1.2-0.80.40.5-0.6
Bouts of movement, locomotor time 10.10.10.20.2-0.1-0.1-0.10.4-0.10.3-0.5-0.40.1-0.2
Total resting periods, locomotor time 10.10.10.60.40.10.10.20.60.1-0.0-0.80.10.3-0.4
Rest time, locomotor task time 11.72.15.10.90.21.61.50.51.4-1.5-2.30.41.9-2.0
Distance moved, locomotor task time 10.71.03.10.40.7-0.9-0.90.5-0.60.81.50.6-1.51.7
Vertical activity count, locomotor time 10.41.02.0-0.5-0.9-1.4-1.3-0.7-0.80.81.4-0.9-1.20.4
Time >=10cm from walls, locomotor time 20.30.41.6-0.4-1.0-0.2-0.1-0.90.1-0.2-0.6-0.30.3-1.3
Bouts of movement, locomotor time 20.40.71.11.00.40.90.70.91.0-1.0-1.0-0.20.8-0.6
Total resting periods, locomotor time 20.40.81.30.90.10.90.70.71.1-1.1-1.1-0.51.0-0.9
Rest time, locomotor task time 20.20.20.6-0.1-0.10.50.6-0.00.3-0.6-0.8-0.30.7-0.7
Distance moved, locomotor task time 20.80.91.90.1-0.4-1.4-1.4-0.2-1.11.11.20.1-1.30.7
Vertical activity count, locomotor time 20.70.91.9-0.4-1.4-1.2-1.2-0.9-0.81.01.1-1.1-0.7-0.2
Light reinforcement 10.00.10.30.4-0.0-0.3-0.20.3-0.20.5-0.00.00.0-0.0
Light reinforcement 20.20.30.80.5-0.90.20.3-0.60.00.00.0-0.90.7-0.8
Bone: marrow area0.40.82.01.40.80.90.90.81.0-0.5-0.70.80.9-0.4
Bone: maximum diameter3.46.38.72.92.12.62.72.02.6-2.6-3.02.22.7-1.9
Bone: maximum force0.10.30.80.1-0.30.60.4-0.30.5-0.6-0.3-0.20.7-0.9
Bone: maximum moment0.20.40.80.3-0.20.90.7-0.30.7-0.7-0.3-0.30.8-0.8
Mean time between licks in bursts0.30.82.5-0.1-1.00.50.2-0.9-0.5-0.5-0.8-1.11.1-1.6
Mean num. licks in bursts0.81.22.20.70.01.31.20.31.4-1.1-1.30.11.5-1.4
Cd content in liver0.91.02.0-1.1-1.4-1.2-1.1-1.3-1.00.81.3-0.5-0.5-0.3
Co content in liver0.30.30.70.3-0.30.70.70.40.9-0.3-0.3-0.80.7-0.7
Cu content in liver1.31.63.4-1.3-1.8-1.3-1.1-1.6-1.11.40.8-1.6-0.5-0.4
Fe content in liver0.40.51.3-0.7-1.1-0.5-0.5-1.0-0.21.10.4-1.10.1-0.3
K content in liver2.62.56.61.72.60.81.02.60.8-0.8-0.82.6-0.51.2
Mg content in liver0.60.72.50.71.20.10.31.30.3-0.3-0.01.6-0.60.7
Mn content in liver2.83.15.82.11.91.81.92.42.0-1.5-1.62.11.0-0.5
Na content in liver0.80.83.00.31.4-0.3-0.01.30.00.0-0.11.7-1.11.2
Rb content in liver0.10.10.20.20.30.50.30.30.30.20.20.20.10.2
Se content in liver1.21.43.2-1.1-0.8-1.5-1.3-0.9-1.11.81.1-0.6-1.31.0
Sr content in liver0.20.20.40.10.2-0.5-0.50.4-0.20.6-0.20.4-0.50.4
Zn content in liver0.80.92.6-0.30.3-1.1-0.80.4-0.61.01.20.5-1.41.6
Bone: minimum diameter0.30.51.4-0.3-1.00.20.2-0.90.1-0.1-0.2-0.90.8-1.2
Time in familiar zone, hab. session 14.84.66.7-2.3-1.5-2.3-2.4-2.1-2.32.62.4-1.5-2.21.7
Time in novel zone, hab. session 13.53.55.62.11.12.12.21.52.4-2.2-1.80.72.3-1.5
Total zone transitions, hab. session 14.66.410.82.83.22.62.43.32.8-2.5-2.33.01.1-0.1
Total locomotion distance, hab. session 13.14.49.12.53.02.12.02.91.8-2.0-1.72.30.70.5
Locomotion velocity, hab. session 14.05.611.72.63.42.42.23.32.0-2.2-1.92.90.60.5
Time in familiar zone, hab. session 20.70.71.7-0.9-0.8-0.6-0.7-1.0-1.01.30.9-1.0-0.60.6
Time in novel zone, hab. session 22.22.34.31.40.91.61.71.12.0-2.1-1.60.81.6-1.2
Total zone transitions, hab. session 24.55.89.52.93.02.62.53.12.4-2.2-2.32.41.4-0.2
Total locomotion distance, hab. session 23.03.99.02.33.02.01.92.81.7-1.6-1.52.30.70.7
Locomotion velocity, hab. session 23.14.29.72.43.12.01.92.91.6-1.6-1.62.50.60.7
Novel to familiar place preference ratio0.10.10.20.2-0.20.40.1-0.3-0.1-0.3-0.2-0.30.3-0.2
Novelty place preference0.20.20.40.3-0.20.60.4-0.30.2-0.5-0.4-0.50.6-0.4
Time in novel zone, NPP test0.40.41.00.5-0.10.90.7-0.20.6-0.7-0.6-0.61.0-0.6
Total zone transitions, NPP test9.413.518.64.34.14.14.03.74.1-3.9-3.63.33.0-1.0
Total locomotion distance, NPP test6.89.416.83.74.13.23.14.03.1-2.8-2.73.01.70.3
Locomotion velocity, NPP test5.47.615.13.43.92.72.63.72.6-2.4-2.33.01.20.5
Intraocular pressure0.60.91.61.01.21.21.01.11.1-1.0-0.70.80.7-0.1
Delta distance traveled before/after self-admin1.51.53.5-1.9-1.3-1.0-1.1-1.8-1.40.61.4-1.0-1.00.4
Delta ambulatory time before/after self-admin0.70.91.5-1.2-0.5-0.8-0.9-1.1-1.10.61.2-0.7-1.10.9
Parametrial fat weight0.20.50.90.70.90.80.61.00.7-0.0-0.40.70.20.6
Pavlov. Cond. lever latency0.81.01.8-0.7-0.2-1.3-1.2-0.2-1.01.31.20.0-1.31.2
Pavlov. Cond. magazine entry latency1.51.94.20.9-0.21.71.80.31.0-1.5-1.5-0.72.1-1.9
Pavlov. Cond. change in total contacts0.50.51.70.2-0.40.60.7-0.10.4-0.7-1.1-0.31.2-1.3
Pavlov. Cond. index score1.21.63.20.8-0.11.51.60.21.1-1.4-1.4-0.61.8-1.7
Pavlov. Cond. latency score1.31.63.40.90.11.61.60.21.2-1.5-1.4-0.41.8-1.6
Pavlov. Cond. lever contacts1.11.32.50.90.21.61.40.31.1-1.5-1.3-0.11.5-1.4
Pavlov. Cond. magazine entry number0.91.12.9-0.20.8-1.0-1.20.3-0.50.90.91.3-1.61.7
Pavlov. Cond. intertrial magazine entries3.64.36.3-2.3-2.1-2.3-2.3-2.0-1.82.52.4-1.8-1.91.0
Pavlov. Cond. lever-magazine prob. diff.1.11.43.20.6-0.31.41.40.10.9-1.3-1.4-0.61.7-1.8
Pavlov. Cond. response bias0.80.92.80.1-0.71.01.0-0.20.5-0.8-1.0-1.11.4-1.7
Pavlov. Cond. lever latency0.10.20.7-0.10.4-0.5-0.50.4-0.5-0.3-0.10.9-0.40.2
Pavlov. Cond. magazine entry latency1.11.33.20.8-0.31.11.4-0.21.1-1.3-1.1-0.61.8-1.7
Pavlov. Cond. change in total contacts0.71.12.61.30.81.51.60.91.4-0.6-0.70.21.1-0.3
Pavlov. Cond. index score0.40.51.20.3-0.70.70.8-0.60.6-0.3-0.3-1.11.1-0.9
Pavlov. Cond. latency score0.40.61.20.3-0.60.80.9-0.50.7-0.4-0.4-0.91.1-0.9
Pavlov. Cond. lever contacts0.30.51.10.3-0.60.80.8-0.60.6-0.1-0.2-1.00.9-0.7
Pavlov. Cond. magazine entry number0.50.61.9-0.40.5-0.5-0.70.2-0.50.70.80.4-1.21.4
Pavlov. Cond. intertrial magazine entries3.75.68.3-2.6-1.6-2.8-2.9-1.7-2.52.52.8-1.1-2.91.7
Pavlov. Cond. lever-magazine prob. diff.0.40.61.20.3-0.70.80.9-0.60.6-0.3-0.4-1.11.1-1.0
Pavlov. Cond. response bias0.40.51.20.6-0.50.90.9-0.30.6-0.2-0.5-0.91.1-1.0
Time in closed arm before self-admin0.60.83.10.91.80.30.51.10.6-0.0-0.21.20.01.3
Time in closed arm after self-admin0.60.61.51.21.10.30.60.90.9-0.6-0.70.80.5-0.1
Time in open arm before self-admin0.80.93.2-0.8-1.5-0.2-0.7-1.2-0.60.80.4-1.8-0.3-0.4
Time in open arm after self-admin1.21.33.1-1.8-1.1-1.1-1.5-0.8-1.70.80.7-0.2-1.40.3
Bone: periosteal estimation1.02.02.91.60.91.61.51.11.7-1.4-1.61.01.6-1.3
Bone: periosteal perimeter1.83.05.01.80.81.92.01.12.0-1.8-2.10.82.2-1.9
Bone: post-yield work0.60.82.1-0.9-1.3-0.8-0.7-1.5-1.20.50.2-0.80.1-1.0
Progressive ratio test 1 active lever presses0.00.10.20.20.3-0.00.10.30.40.0-0.0-0.30.30.1
Progressive ratio test 1 breakpoint0.10.10.20.20.40.00.10.40.5-0.0-0.0-0.20.30.1
Progressive ratio test 1 inactive lever presses0.20.30.8-0.50.2-0.7-0.7-0.2-0.40.50.7-0.2-0.90.8
Progressive ratio test 2 active lever presses0.30.31.80.3-0.40.40.4-0.30.50.60.3-1.40.4-0.0
Progressive ratio test 2 breakpoint0.30.31.90.2-0.40.20.3-0.30.40.70.4-1.40.30.1
Progressive ratio test 2 inactive lever presses0.10.20.6-0.6-0.6-0.4-0.3-0.7-0.30.60.2-0.6-0.2-0.1
Incentive Sensitization - Responses0.40.52.00.4-0.90.70.5-0.40.70.80.1-1.40.6-0.5
Incentive Sensitization - Breakpoint0.40.62.20.3-0.90.70.6-0.50.70.7-0.0-1.50.7-0.6
Sum of active levers in priming session hrs 5-60.60.61.20.8-0.30.71.10.50.9-0.9-0.5-0.70.8-0.9
Progressive ratio1.01.63.80.90.71.71.50.71.2-1.2-2.00.51.5-1.1
Food seeking constrained by brief footshock0.40.51.30.10.30.20.30.50.6-0.7-0.90.90.8-1.1
Seeking ratio, punishment vs. effort0.20.21.0-0.3-0.4-1.0-0.8-0.2-0.40.50.50.1-0.4-0.3
Retroperitoneal fat weight1.04.47.52.72.72.62.12.72.2-1.6-1.71.71.20.4
Reaction time number correct0.20.41.31.01.00.10.21.10.50.0-0.20.80.10.7
Reaction time mean minus median0.61.64.10.91.00.20.81.30.9-1.7-2.01.81.0-0.9
Reaction time mean minus median AUC0.92.35.21.31.50.61.11.71.6-1.9-2.02.31.0-0.7
Reaction time num false alarms1.11.52.8-1.7-1.2-1.0-1.5-1.4-1.01.61.0-1.1-0.90.6
Reaction time num false alarms AUC1.21.93.9-2.0-1.3-1.5-1.9-1.5-1.31.51.0-0.8-1.20.5
Reaction time trials correct on left0.20.41.31.01.00.10.21.10.50.0-0.20.80.10.7
Reaction time trials on left0.20.51.31.01.00.10.21.10.50.0-0.20.90.10.7
Reaction time mean0.40.72.3-0.4-0.5-0.1-0.00.1-0.2-1.2-1.41.00.5-1.5
Reaction time mean AUC0.30.41.2-0.7-0.6-0.4-0.4-0.1-0.5-0.7-0.90.80.1-1.1
Median of all reaction times0.40.51.8-0.9-1.0-0.4-0.5-0.4-0.8-0.6-0.70.40.1-1.3
Reaction time omissions0.20.31.3-0.10.6-0.3-0.30.3-0.5-0.10.01.2-0.70.8
Reaction time false alarm rate1.41.94.6-2.2-1.5-1.2-1.6-1.8-1.31.40.9-1.1-1.00.2
Reaction time premature initiation rate0.20.31.1-0.1-0.3-0.7-0.5-0.6-0.91.10.3-0.0-0.30.2
Reaction time premature initiations0.10.20.60.70.4-0.4-0.20.2-0.30.80.10.6-0.10.5
Std. dev. reaction times0.50.92.80.20.5-0.00.30.80.2-1.3-1.71.70.5-0.9
Reaction time trials completed0.20.51.31.01.00.10.21.10.50.0-0.20.90.10.7
Reaction time trials AUC0.20.30.90.80.8-0.10.00.90.30.2-0.10.7-0.00.7
Run reversals in cocaine runway, females0.80.83.00.71.40.50.41.00.3-0.00.60.9-0.91.7
Run reversals in cocaine runway, males1.31.35.10.3-0.90.70.8-0.50.8-0.9-1.5-0.51.8-2.3
Latency to leave start box in cocaine runway1.82.03.3-1.8-1.5-1.6-1.5-1.4-1.51.01.7-1.2-1.70.4
Latency to leave start box in cocaine runway, F1.11.32.7-1.4-0.6-1.2-1.3-0.8-1.20.71.3-0.5-1.61.1
Latency to leave start box in cocaine runway, M1.11.02.0-1.0-1.4-1.1-1.0-0.9-0.90.91.1-1.2-0.8-0.5
Std. dev. time between licks in bursts0.10.10.2-0.1-0.1-0.1-0.40.2-0.50.40.30.1-0.50.0
Total sessions with >9 infusions0.30.30.8-0.00.9-0.3-0.30.70.2-0.00.60.8-0.50.9
Short access day 1 total inactive lever presses1.01.35.80.81.8-0.1-0.01.80.2-0.9-0.12.4-0.60.7
Short access day 10 total inactive lever presses0.30.83.10.60.50.90.70.60.5-1.2-1.80.90.5-0.9
Short access day 1 total infusions0.40.51.2-0.50.4-1.1-1.10.4-0.40.60.50.9-0.90.8
Short access day 10 total infusions0.40.61.31.01.00.60.51.01.2-0.6-0.40.50.8-0.2
Short access total infusions0.20.20.60.30.8-0.3-0.30.80.40.20.30.6-0.20.6
Short access day 1 locomotion1.01.33.50.31.9-0.3-0.31.80.1-0.00.11.9-1.01.6
Short access day 10 total locomotion0.81.64.20.71.01.11.20.90.9-2.0-1.81.40.9-1.2
Short access total locomotion1.31.63.71.01.90.91.01.71.2-1.4-1.01.70.40.3
One hour access (0.3 mA shock)0.30.40.9-0.7-0.5-0.8-0.6-0.6-0.30.90.5-0.7-0.30.4
Compulsive drug intake3.54.29.1-1.8-0.8-2.1-2.2-1.1-2.21.82.7-0.7-3.02.6
One hour access (shock baseline)0.30.51.6-0.3-1.00.00.1-0.70.40.6-0.3-1.01.1-1.3
Social response proportion0.50.61.7-1.0-1.3-0.5-0.5-1.3-0.6-0.10.1-0.70.2-0.9
Social responses0.10.20.8-0.4-0.8-0.3-0.2-0.4-0.1-0.1-0.1-0.10.3-0.9
Social time0.50.61.8-1.1-1.3-0.6-0.5-0.8-0.5-0.2-0.4-0.50.4-1.3
Soleus weight1.02.95.42.01.91.91.81.92.3-1.6-1.61.51.2-0.3
Bone: stiffness0.30.41.5-0.6-1.0-0.3-0.3-0.9-0.3-0.1-0.3-0.70.5-1.2
Tibialis anterior weight1.13.67.02.41.92.12.21.62.6-2.0-1.71.11.9-0.4
Time to tail flick, vehicle, before self-admin0.10.10.40.00.40.10.10.5-0.10.1-0.60.5-0.30.3
Time to tail flick, vehicle, after self-admin1.01.32.30.91.51.31.31.51.4-1.3-1.10.90.70.1
Time to tail flick, test, before self-admin0.10.10.30.0-0.0-0.6-0.50.2-0.20.5-0.60.20.0-0.3
Time to tail flick, test, after self-admin0.20.21.00.5-0.40.50.6-0.20.20.5-0.0-1.00.3-0.3
Delta time to tail flick, vehicle, before/after SA0.50.51.30.50.80.70.70.61.0-1.1-0.40.50.5-0.1
Delta time to tail flick, test, before/after SA0.10.10.30.50.30.60.6-0.00.10.20.5-0.1-0.10.5
Tibia length0.30.71.41.11.01.21.10.51.0-0.9-0.50.20.90.2
Ambulatory time before self-admin0.91.42.30.91.11.21.21.21.3-1.5-1.41.21.1-0.7
Ambulatory time after self-admin0.10.10.9-0.40.00.0-0.0-0.4-0.0-0.90.20.0-0.00.1
Bone: tissue strength0.10.10.30.60.40.40.40.40.4-0.2-0.4-0.10.30.1
Total heroin consumption1.01.24.80.1-1.60.50.6-1.20.70.40.0-2.21.2-1.4
Bone: trabecular number2.13.56.3-2.2-2.2-1.5-1.9-2.1-2.52.01.7-1.9-1.40.2
Bone: trabecular spacing0.60.82.51.11.40.30.61.00.7-1.0-0.31.6-0.10.5
Bone: trabecular thickness0.50.62.80.51.10.60.30.80.40.50.80.1-0.71.7
Bone: trabecular tissue density1.82.64.21.71.81.92.01.52.0-1.9-1.31.21.3-0.3
Water consumed over 24 hours0.40.62.8-0.5-1.2-0.2-0.4-0.80.10.80.1-1.70.3-0.7
Number of responses in last shaping day1.01.14.41.11.40.40.41.40.4-1.1-1.12.10.3-0.1