Hub : Genes

P4ha2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression P4ha2 0.02 0.02 2.6e-04 0.02 0.02 0.01 0.02 2.1e-04 2.7e-04 2.6e-03 4.2e-04
2 LHb gene expression P4ha2 0.2 0.17 1.5e-03 0.06 0.08 0.06 0.06 1.8e-02 7.2e-03 1.3e-02 2.0e-02
3 PL intron excision ratio chr10_38756592_38759859 0.02 0.02 9.7e-03 0 0.01 0 0 7.5e-02 5.5e-02 2.1e-01 1.6e-01
4 PL mRNA stability P4ha2 0.05 0.04 8.5e-06 0.05 0.04 0.05 0.05 5.0e-06 2.5e-05 4.3e-06 7.1e-06
5 IC intron excision ratio chr10_38767889_38770202 0.06 0.06 5.4e-03 0.08 0.06 0.06 0.07 2.7e-04 1.7e-03 1.3e-03 5.5e-04
6 IC intron excision ratio chr10_38768003_38770202 0.06 0.06 5.6e-03 0.08 0.06 0.06 0.07 2.7e-04 1.8e-03 1.2e-03 5.8e-04
7 pVTA gene expression P4ha2 0.15 0.17 1.5e-08 0.09 0.1 0.1 0.1 1.5e-07 1.7e-08 2.2e-08 3.9e-08
8 Liver intron excision ratio chr10_38767410_38767938 0.02 0.02 6.3e-03 0.01 0.01 0.01 0.01 1.1e-02 2.1e-02 2.0e-02 1.7e-02
9 Liver intron excision ratio chr10_38767410_38767830 0.03 0.03 5.1e-03 0.01 0.01 0.01 0.01 8.7e-03 1.7e-02 1.4e-02 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.10.10.20.30.3-0.2-0.4-0.30.30.20.5-0.5
Area under the delay curve0.10.10.2-0.3-0.40.40.40.2-0.2-0.4-0.40.4
BMI with tail0.00.10.2-0.3-0.40.30.20.4-0.4-0.3-0.20.2
BMI without tail0.31.01.1-0.9-1.01.00.90.9-0.9-1.0-1.01.0
Body weight0.83.53.8-1.8-1.91.91.81.9-1.9-1.8-2.02.0
Weight adjusted by age0.00.00.1-0.2-0.00.10.00.2-0.2-0.00.0-0.0
Bone surface0.00.00.0-0.2-0.10.10.10.2-0.2-0.2-0.10.1
Bone volume0.30.50.60.70.7-0.6-0.8-0.60.60.60.7-0.7
Breakpoint value in progressive ratio session1.11.31.81.11.3-1.3-1.2-0.90.91.31.0-1.0
Number of licking bursts0.10.20.2-0.3-0.40.40.40.3-0.3-0.4-0.40.4
Context. condit. distance diff. score0.00.00.0-0.1-0.10.20.00.1-0.1-0.20.1-0.1
Locomotion velocity, session 10.10.10.10.30.3-0.3-0.2-0.30.30.30.1-0.1
Locomotion distance, session 10.40.50.8-0.6-0.50.50.70.6-0.6-0.6-0.90.9
Locomotion velocity, session 20.81.01.3-0.9-1.01.00.90.9-0.9-1.0-1.11.1
Locomotion distance, session 20.60.81.2-0.8-0.80.70.90.8-0.8-0.8-1.11.1
Locomotion velocity, session 32.73.13.4-1.8-1.71.71.71.8-1.8-1.7-1.91.9
Locomotion distance, session 32.12.32.5-1.5-1.51.61.51.5-1.5-1.6-1.51.5
Stereotopy head waving bouts, day 30.20.20.40.50.6-0.6-0.5-0.40.40.60.4-0.4
Stereotopy head waving duration, day 31.72.02.41.51.5-1.6-1.5-1.41.41.51.2-1.2
Locomotion velocity, session 70.00.00.1-0.0-0.00.00.10.1-0.1-0.0-0.40.4
Locomotion distance, session 70.00.10.10.30.3-0.4-0.1-0.30.30.3-0.00.0
Stereotopy head waving bouts, day 70.20.20.20.50.4-0.4-0.5-0.50.50.40.5-0.5
Stereotopy head waving duration, day 71.11.41.51.21.2-1.2-1.2-1.21.21.21.1-1.1
Locomotion velocity, session 82.22.73.0-1.6-1.71.71.61.6-1.6-1.7-1.61.6
Locomotion distance, session 80.91.31.4-1.1-1.11.11.21.1-1.1-1.1-1.21.2
Degree of sensitization distance2.52.63.31.61.7-1.8-1.6-1.61.61.81.4-1.4
Degree of sensitization stereotypy0.10.10.10.20.2-0.2-0.3-0.30.30.20.3-0.3
Conditioned locomotion0.40.50.7-0.8-0.70.70.70.8-0.8-0.6-0.50.5
Cocaine response after cond. corrected0.00.00.10.20.2-0.1-0.3-0.20.20.20.2-0.2
Cocaine response after cond. not corrected0.60.80.90.90.8-0.8-0.9-0.90.90.80.8-0.8
Cocaine response before conditioning2.12.52.61.61.6-1.6-1.5-1.61.61.61.6-1.6
Saline control response0.91.21.71.01.3-1.3-1.1-0.90.91.31.0-1.0
Bone: connectivity density0.00.00.10.20.2-0.2-0.3-0.20.20.20.3-0.3
Bone: cortical apparent density0.81.11.61.01.0-0.9-1.1-1.01.01.01.2-1.2
Bone: cortical area0.61.01.1-0.9-1.00.91.10.9-0.9-1.0-1.01.0
Bone: cortical porosity0.30.30.4-0.4-0.50.50.50.5-0.5-0.5-0.60.6
Bone: cortical porosity0.50.50.70.90.7-0.7-0.8-0.80.80.70.6-0.6
Bone: cortical thickness0.40.70.8-0.8-0.80.80.90.8-0.8-0.8-0.90.9
Bone: cortical thickness0.10.10.10.30.3-0.4-0.3-0.30.30.40.4-0.4
Bone: cortical tissue density1.01.42.01.11.1-1.0-1.2-1.11.11.11.4-1.4
Condit. Reinf. active minus inactive responses0.20.30.3-0.5-0.50.60.50.6-0.6-0.6-0.40.4
Condit. Reinf. active-inactive response ratio0.90.91.2-1.0-1.11.10.91.1-1.1-1.0-0.70.7
Condit. Reinf. active responses0.00.00.10.20.2-0.2-0.1-0.20.20.20.3-0.3
Condit. Reinf. inactive responses1.82.22.61.41.6-1.6-1.4-1.41.41.61.3-1.3
Incentive salience index mean1.31.61.8-1.3-1.31.31.31.3-1.3-1.3-1.11.1
Condit. Reinf. lever presses2.83.94.2-2.0-2.01.92.12.0-2.0-1.9-1.91.9
Condit. Reinf. active minus inactive responses0.50.60.70.70.8-0.8-0.8-0.70.70.80.9-0.9
Condit. Reinf. active-inactive response ratio0.10.10.1-0.3-0.40.40.30.3-0.3-0.3-0.30.3
Condit. Reinf. active responses1.72.32.51.51.6-1.6-1.6-1.51.51.61.5-1.5
Condit. Reinf. inactive responses4.05.25.72.32.4-2.4-2.3-2.32.32.42.1-2.1
Condit. Reinf. lever presses0.20.20.30.50.5-0.5-0.5-0.50.50.50.4-0.4
Condit. Reinf. lever reinforcers received1.52.12.21.41.5-1.5-1.5-1.41.41.51.4-1.4
Conditioned reinforcement - actives0.00.00.20.40.0-0.1-0.1-0.20.20.00.0-0.0
Conditioned reinforcement - inactives0.91.32.81.71.1-1.1-1.1-1.21.21.10.9-0.9
Conditioned locomotion0.60.81.01.00.8-0.8-1.0-0.60.60.91.0-1.0
Patch foraging indifference point 0 sec3.36.06.52.32.5-2.5-2.4-2.32.32.52.5-2.5
Patch foraging indifference point AUC0.00.00.1-0.3-0.10.10.00.3-0.3-0.10.1-0.1
Delay disc. indifference point, 0s delay0.00.00.1-0.10.1-0.1-0.00.1-0.10.10.4-0.4
Delay disc. indifference point, 16s delay0.00.00.10.0-0.10.10.1-0.20.2-0.1-0.30.3
Delay disc. indifference point, 2s delay1.21.31.5-1.2-1.21.21.21.1-1.1-1.2-1.11.1
Delay disc. indifference point, 24s delay0.10.10.2-0.1-0.40.40.40.0-0.0-0.4-0.40.4
Delay disc. indifference point, 4s delay1.21.21.61.31.1-1.1-1.1-1.21.21.10.9-0.9
Delay disc. indifference point, 8s delay0.30.30.4-0.5-0.60.60.60.6-0.6-0.6-0.60.6
Indifference point function ln k0.20.40.4-0.5-0.50.50.60.6-0.6-0.6-0.60.6
Indifference point function log k0.20.40.4-0.5-0.50.50.60.6-0.6-0.6-0.60.6
Patch foraging total patch changes 0 sec3.46.47.12.42.6-2.6-2.5-2.42.42.62.7-2.7
Patch foraging total patch changes 12 sec4.86.26.52.52.5-2.6-2.5-2.52.52.52.5-2.5
Patch foraging total patch changes 18 sec1.72.73.91.31.6-1.6-1.7-1.41.41.72.0-2.0
Patch foraging total patch changes 24 sec2.44.14.61.92.1-2.1-2.0-1.91.92.02.1-2.1
Patch foraging total patch changes 6 sec4.16.26.72.52.6-2.6-2.5-2.52.52.52.4-2.4
Patch foraging time to switch 0 sec0.40.81.51.20.8-0.8-0.7-1.21.20.70.3-0.3
Patch foraging water rate 0 sec0.40.81.2-1.1-0.80.80.81.1-1.1-0.8-0.70.7
Patch foraging water rate 12 sec0.20.40.7-0.7-0.60.60.60.9-0.9-0.6-0.50.5
Patch foraging water rate 18 sec1.01.51.71.31.2-1.3-1.3-1.21.21.31.2-1.2
Patch foraging water rate 24 sec0.40.60.80.70.7-0.7-0.8-0.50.50.80.9-0.9
Patch foraging water rate 6 sec1.72.43.0-1.4-1.41.41.61.7-1.7-1.5-1.61.6
Seeking ratio, delayed vs. immediate footshock0.50.61.10.70.7-0.7-0.8-0.50.50.71.1-1.1
Distance traveled before self-admin1.72.22.5-1.5-1.51.51.41.6-1.6-1.5-1.41.4
Distance traveled after self-admin0.00.00.0-0.1-0.10.10.10.2-0.2-0.1-0.20.2
Extensor digitorum longus weight0.20.91.01.00.9-0.9-0.9-1.01.00.90.9-0.9
Bone: elastic displacement0.00.00.00.1-0.10.1-0.10.0-0.0-0.10.1-0.1
Bone: elastic work0.60.81.0-0.9-1.01.00.90.9-0.9-1.0-0.60.6
Bone: endosteal estimation0.61.31.7-1.1-1.11.11.11.1-1.1-1.1-1.31.3
Bone: endosteal perimeter1.02.13.0-1.3-1.41.31.51.3-1.3-1.4-1.71.7
Epididymis fat weight0.10.50.6-0.6-0.70.70.60.8-0.8-0.7-0.60.6
Delta time in closed arm before/after self-admin0.10.10.5-0.70.3-0.30.10.3-0.30.30.2-0.2
Delta time in open arm before/after self-admin0.10.10.30.2-0.50.50.20.2-0.2-0.4-0.20.2
Diff in mean of infusions in LGA sessions0.00.00.1-0.20.0-0.0-0.10.3-0.30.00.0-0.0
Delay discount exponential model param0.10.10.20.20.4-0.4-0.4-0.20.20.40.4-0.4
Extinction: sum of active levers before priming0.00.00.1-0.4-0.00.00.20.2-0.2-0.0-0.00.0
Active lever presses in extinction session 61.21.21.41.11.1-1.2-1.0-1.21.21.10.9-0.9
Bone: final force1.52.32.5-1.5-1.51.51.51.5-1.5-1.5-1.61.6
Bone: final moment1.42.22.4-1.4-1.51.51.51.5-1.5-1.5-1.61.6
Food consumed during 24 hour testing period5.98.18.5-2.9-2.92.92.92.9-2.9-2.9-2.72.7
Glucose0.20.30.6-0.3-0.50.50.60.3-0.3-0.6-0.80.8
Heart weight1.32.02.8-1.3-1.61.71.61.0-1.0-1.7-1.41.4
Delay discount hyperbolic model param0.00.00.00.10.2-0.2-0.2-0.00.00.20.2-0.2
Intermittent access intake day 1-15 change0.50.91.31.10.9-1.0-1.0-1.11.10.90.7-0.7
Intermittent access intake escalation0.51.01.31.11.0-1.0-1.0-1.11.10.90.8-0.8
Intermittent access intake escalation 21.92.12.41.31.5-1.5-1.4-1.51.51.51.4-1.4
Intermitt. access day 1 inactive lever presses0.10.50.70.80.7-0.7-0.8-0.60.60.70.8-0.8
Intermitt. access day 15 inactive lever presses0.00.00.10.30.1-0.1-0.2-0.10.10.10.3-0.3
Intermitt. access escalation Index0.20.20.7-0.4-0.30.30.40.0-0.0-0.3-0.80.8
Intermittent access day 1 total infusions0.00.00.1-0.1-0.20.20.20.3-0.3-0.1-0.20.2
Intermittent access day 15 total infusions0.10.20.50.70.4-0.4-0.3-0.50.50.3-0.10.1
Intermittent access terminal intake (last 3 days)0.30.30.70.80.6-0.6-0.4-0.80.80.50.0-0.0
Intermittent access total infusions0.10.10.20.4-0.00.00.2-0.20.2-0.1-0.40.4
Intermittent access day 1 locomotion0.00.00.1-0.00.1-0.1-0.00.0-0.00.10.3-0.3
Intermittent access day 15 total locomotion2.85.26.72.62.3-2.3-2.2-2.42.42.22.0-2.0
Intermittent access total locomotion3.34.04.82.22.1-2.1-1.9-2.02.02.01.8-1.8
Intermittent access standard deviation0.30.60.9-0.8-0.60.60.70.9-0.9-0.7-1.01.0
Left kidney weight5.625.928.9-5.4-5.05.05.15.2-5.2-4.9-5.05.0
Right kidney weight4.419.921.3-4.5-4.64.64.44.3-4.3-4.5-4.54.5
Cocaine induced anxiety0.20.30.91.00.3-0.3-0.6-0.60.60.30.3-0.3
Post-drug Anxiety0.40.40.80.90.6-0.6-0.7-0.60.60.50.6-0.6
Baseline Anxiety0.70.81.3-1.1-0.80.81.01.1-1.1-0.8-0.60.6
Tail length1.14.25.0-2.0-2.12.12.01.9-1.9-2.0-2.22.2
Length with tail1.04.35.2-1.9-2.22.12.11.8-1.8-2.0-2.32.3
Length without tail0.30.81.0-0.9-0.90.90.91.0-1.0-0.8-0.90.9
Times rat made contact with spout1.01.11.4-1.0-1.11.11.21.0-1.0-1.1-1.11.1
Lifetime Intake0.20.30.70.0-0.40.40.60.3-0.3-0.5-0.90.9
Liver weight, left0.10.10.20.30.4-0.4-0.4-0.30.30.40.1-0.1
Liver weight, right0.10.10.2-0.1-0.30.30.30.2-0.2-0.3-0.40.4
Locomotor activity1.92.93.31.81.7-1.6-1.8-1.81.81.71.6-1.6
Locomotor testing distance3.66.47.42.42.4-2.4-2.7-2.42.42.52.7-2.7
Locomotor testing rearing2.04.05.51.71.9-1.9-2.2-1.81.82.02.3-2.3
Locomotion in novel chamber0.10.10.40.60.0-0.1-0.1-0.40.4-0.0-0.00.0
Locomotion in novel chamber post-restriction0.00.00.00.10.0-0.00.10.0-0.00.0-0.00.0
Fecal boli incidents, locomotor time 10.00.00.10.30.2-0.2-0.30.0-0.00.20.1-0.1
Change in fecal boli incidents, locomotor task1.11.11.5-0.9-1.21.21.10.7-0.7-1.2-1.11.1
Time >=10cm from walls, locomotor time 12.93.13.61.91.8-1.8-1.8-1.91.91.81.5-1.5
Bouts of movement, locomotor time 10.30.30.60.80.5-0.5-0.5-0.50.50.50.5-0.5
Total resting periods, locomotor time 10.10.10.40.60.4-0.3-0.3-0.40.40.30.2-0.2
Rest time, locomotor task time 10.20.30.40.50.6-0.6-0.5-0.40.40.60.4-0.4
Distance moved, locomotor task time 10.00.00.1-0.1-0.20.20.2-0.10.1-0.2-0.30.3
Vertical activity count, locomotor time 10.30.71.00.90.7-0.7-0.9-1.01.00.70.9-0.9
Time >=10cm from walls, locomotor time 20.00.00.0-0.0-0.00.0-0.00.1-0.1-0.00.0-0.0
Bouts of movement, locomotor time 20.10.20.50.70.3-0.3-0.4-0.50.50.30.5-0.5
Total resting periods, locomotor time 20.10.20.40.70.2-0.3-0.4-0.50.50.30.4-0.4
Rest time, locomotor task time 21.21.52.01.41.3-1.3-1.2-1.41.41.20.9-0.9
Distance moved, locomotor task time 20.10.10.10.20.3-0.3-0.2-0.20.20.30.3-0.3
Vertical activity count, locomotor time 20.20.30.50.40.5-0.5-0.6-0.30.30.50.7-0.7
Light reinforcement 10.92.22.61.41.5-1.5-1.5-1.31.31.51.6-1.6
Light reinforcement 20.10.10.2-0.0-0.30.30.30.1-0.1-0.3-0.50.5
Bone: marrow area0.81.62.1-1.2-1.21.21.31.2-1.2-1.2-1.41.4
Bone: maximum diameter1.63.03.4-1.6-1.71.71.81.6-1.6-1.7-1.81.8
Bone: maximum force0.61.11.4-1.0-1.01.01.01.0-1.0-1.0-1.21.2
Bone: maximum moment0.61.01.2-0.9-0.90.91.01.0-1.0-0.9-1.11.1
Mean time between licks in bursts1.43.33.5-1.8-1.91.91.81.8-1.8-1.9-1.81.8
Mean num. licks in bursts0.00.00.00.20.2-0.2-0.2-0.20.20.20.2-0.2
Cd content in liver2.02.22.71.31.5-1.5-1.5-1.41.41.51.6-1.6
Co content in liver0.00.00.0-0.0-0.00.00.10.1-0.1-0.0-0.00.0
Cu content in liver0.00.00.00.0-0.10.10.0-0.00.0-0.10.1-0.1
Fe content in liver0.00.00.00.1-0.10.10.0-0.10.1-0.10.1-0.1
K content in liver12.712.212.5-3.5-3.53.43.53.5-3.5-3.4-3.53.5
Mg content in liver2.62.73.0-1.7-1.61.51.61.7-1.7-1.5-1.61.6
Mn content in liver0.00.00.10.10.2-0.3-0.1-0.00.00.2-0.10.1
Na content in liver1.61.72.0-1.3-1.31.31.31.3-1.3-1.3-1.41.4
Rb content in liver2.32.64.61.51.4-1.4-1.5-1.41.41.52.1-2.1
Se content in liver1.31.51.9-1.2-1.41.41.31.3-1.3-1.4-0.80.8
Sr content in liver0.00.00.1-0.3-0.0-0.00.20.2-0.20.0-0.20.2
Zn content in liver0.60.60.8-0.8-0.80.80.90.8-0.8-0.8-0.70.7
Bone: minimum diameter0.91.72.0-1.3-1.31.31.41.3-1.3-1.3-1.31.3
Time in familiar zone, hab. session 18.27.98.72.92.9-2.9-2.9-2.92.92.82.5-2.5
Time in novel zone, hab. session 15.55.55.8-2.3-2.42.42.42.4-2.4-2.3-2.22.2
Total zone transitions, hab. session 10.00.10.10.30.2-0.2-0.0-0.30.30.2-0.20.2
Total locomotion distance, hab. session 10.40.60.80.80.9-0.9-0.7-0.90.90.80.4-0.4
Locomotion velocity, hab. session 10.10.10.20.40.4-0.5-0.3-0.40.40.4-0.10.1
Time in familiar zone, hab. session 21.21.21.71.31.2-1.2-1.1-1.31.31.10.7-0.7
Time in novel zone, hab. session 23.33.33.6-1.9-1.91.91.91.9-1.9-1.8-1.61.6
Total zone transitions, hab. session 20.20.20.6-0.2-0.30.40.50.2-0.2-0.4-0.80.8
Total locomotion distance, hab. session 20.20.20.40.60.6-0.5-0.4-0.60.60.50.2-0.2
Locomotion velocity, hab. session 20.00.00.10.30.2-0.2-0.2-0.30.30.2-0.10.1
Novel to familiar place preference ratio0.20.20.50.40.4-0.4-0.4-0.40.40.40.7-0.7
Novelty place preference0.10.10.20.30.3-0.3-0.2-0.30.30.30.5-0.5
Time in novel zone, NPP test0.10.10.20.30.3-0.3-0.2-0.30.30.30.5-0.5
Total zone transitions, NPP test0.10.10.20.40.3-0.4-0.2-0.40.40.3-0.00.0
Total locomotion distance, NPP test0.20.20.20.50.5-0.5-0.4-0.40.40.50.4-0.4
Locomotion velocity, NPP test0.10.20.20.40.5-0.5-0.4-0.40.40.50.4-0.4
Intraocular pressure0.20.30.40.40.5-0.5-0.4-0.50.50.50.6-0.6
Delta distance traveled before/after self-admin1.41.41.81.31.2-1.2-1.2-1.21.21.21.1-1.1
Delta ambulatory time before/after self-admin1.82.32.51.61.5-1.5-1.5-1.51.51.51.4-1.4
Parametrial fat weight2.14.95.6-2.4-2.32.22.12.3-2.3-2.1-2.12.1
Pavlov. Cond. lever latency0.20.20.30.50.5-0.5-0.4-0.50.50.40.3-0.3
Pavlov. Cond. magazine entry latency0.00.10.1-0.3-0.30.30.30.3-0.3-0.20.1-0.1
Pavlov. Cond. change in total contacts0.00.00.20.10.1-0.0-0.2-0.10.10.10.4-0.4
Pavlov. Cond. index score0.10.10.2-0.4-0.30.40.30.4-0.4-0.30.0-0.0
Pavlov. Cond. latency score0.10.20.3-0.5-0.40.40.40.5-0.5-0.4-0.10.1
Pavlov. Cond. lever contacts0.10.20.2-0.4-0.40.40.40.5-0.5-0.4-0.20.2
Pavlov. Cond. magazine entry number0.00.00.2-0.0-0.0-0.00.1-0.00.0-0.0-0.50.5
Pavlov. Cond. intertrial magazine entries1.21.41.71.21.3-1.3-1.2-1.21.21.30.9-0.9
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.2-0.20.20.10.2-0.2-0.10.2-0.2
Pavlov. Cond. response bias0.00.00.1-0.1-0.10.10.00.1-0.1-0.10.3-0.3
Pavlov. Cond. lever latency0.81.01.11.01.0-1.0-1.0-1.11.11.01.0-1.0
Pavlov. Cond. magazine entry latency0.60.71.0-0.8-1.01.00.90.8-0.8-1.0-0.50.5
Pavlov. Cond. change in total contacts0.00.00.2-0.1-0.00.0-0.00.1-0.10.00.4-0.4
Pavlov. Cond. index score0.50.70.9-0.9-0.90.90.90.9-0.9-0.9-0.60.6
Pavlov. Cond. latency score0.70.91.1-1.0-1.11.11.01.0-1.0-1.0-0.70.7
Pavlov. Cond. lever contacts0.70.91.0-1.0-1.01.01.01.0-1.0-1.0-0.90.9
Pavlov. Cond. magazine entry number0.00.10.10.20.4-0.4-0.2-0.20.20.3-0.10.1
Pavlov. Cond. intertrial magazine entries2.74.14.61.92.1-2.1-2.0-1.91.92.12.0-2.0
Pavlov. Cond. lever-magazine prob. diff.0.50.70.9-0.9-0.90.90.90.9-0.9-0.9-0.60.6
Pavlov. Cond. response bias1.01.31.5-1.2-1.21.21.21.2-1.2-1.2-1.01.0
Time in closed arm before self-admin0.50.71.1-0.3-1.11.10.70.6-0.6-1.0-0.90.9
Time in closed arm after self-admin0.80.91.6-1.3-0.80.80.91.1-1.1-0.8-0.70.7
Time in open arm before self-admin0.60.71.10.21.1-1.1-0.7-0.60.61.00.8-0.8
Time in open arm after self-admin1.31.42.01.41.1-1.1-1.1-1.21.21.11.2-1.2
Bone: periosteal estimation1.02.22.5-1.4-1.41.41.51.5-1.5-1.4-1.61.6
Bone: periosteal perimeter0.91.52.2-1.1-1.21.21.31.1-1.1-1.2-1.51.5
Bone: post-yield work0.81.21.31.11.1-1.1-1.2-1.11.11.11.0-1.0
Progressive ratio test 1 active lever presses0.30.41.11.10.6-0.6-0.5-0.70.70.50.3-0.3
Progressive ratio test 1 breakpoint0.50.61.51.20.7-0.7-0.6-0.90.90.70.5-0.5
Progressive ratio test 1 inactive lever presses0.10.10.30.2-0.50.50.30.3-0.3-0.5-0.30.3
Progressive ratio test 2 active lever presses0.40.51.11.10.7-0.7-0.6-0.70.70.60.5-0.5
Progressive ratio test 2 breakpoint0.70.81.51.20.9-0.9-0.8-0.90.90.80.6-0.6
Progressive ratio test 2 inactive lever presses0.10.20.91.00.3-0.3-0.3-0.50.50.20.1-0.1
Incentive Sensitization - Responses1.01.31.91.41.1-1.1-1.2-1.21.21.01.2-1.2
Incentive Sensitization - Breakpoint0.91.11.51.21.0-1.0-1.1-1.01.00.91.1-1.1
Sum of active levers in priming session hrs 5-60.10.10.1-0.10.3-0.3-0.2-0.30.30.30.3-0.3
Progressive ratio0.40.61.31.10.5-0.5-0.8-1.01.00.50.8-0.8
Food seeking constrained by brief footshock0.10.10.2-0.00.4-0.4-0.3-0.00.00.40.4-0.4
Seeking ratio, punishment vs. effort0.60.92.0-1.4-0.60.60.81.3-1.3-0.6-0.80.8
Retroperitoneal fat weight1.35.76.6-2.2-2.32.32.32.4-2.4-2.3-2.62.6
Reaction time number correct0.20.50.80.80.7-0.7-0.6-0.90.90.60.4-0.4
Reaction time mean minus median0.10.20.3-0.4-0.30.30.50.1-0.1-0.4-0.60.6
Reaction time mean minus median AUC0.00.10.30.30.1-0.10.1-0.50.50.0-0.20.2
Reaction time num false alarms0.40.50.60.70.7-0.7-0.8-0.80.80.70.6-0.6
Reaction time num false alarms AUC0.81.21.51.21.0-1.1-1.1-1.21.21.10.9-0.9
Reaction time trials correct on left0.20.50.80.80.7-0.7-0.6-0.90.90.60.4-0.4
Reaction time trials on left0.20.40.80.80.6-0.6-0.6-0.90.90.50.4-0.4
Reaction time mean1.11.82.0-1.4-1.21.31.41.3-1.3-1.3-1.41.4
Reaction time mean AUC0.91.41.8-1.2-1.11.11.31.1-1.1-1.2-1.31.3
Median of all reaction times1.72.52.7-1.6-1.51.51.61.6-1.6-1.5-1.61.6
Reaction time omissions0.50.70.9-0.8-0.90.90.90.7-0.7-0.9-0.90.9
Reaction time false alarm rate0.10.20.20.40.3-0.3-0.5-0.40.40.40.4-0.4
Reaction time premature initiation rate0.50.71.20.81.1-1.1-0.7-0.80.81.00.6-0.6
Reaction time premature initiations0.81.52.11.31.4-1.4-1.1-1.31.31.30.9-0.9
Std. dev. reaction times0.00.00.1-0.1-0.00.00.2-0.10.1-0.1-0.30.3
Reaction time trials completed0.20.40.80.80.6-0.6-0.6-0.90.90.50.4-0.4
Reaction time trials AUC0.30.60.90.90.8-0.8-0.7-1.01.00.70.5-0.5
Run reversals in cocaine runway, females0.10.10.2-0.2-0.40.50.40.1-0.1-0.4-0.20.2
Run reversals in cocaine runway, males0.10.10.10.40.2-0.2-0.4-0.20.20.20.3-0.3
Latency to leave start box in cocaine runway1.11.21.6-1.2-1.11.11.31.0-1.0-1.1-1.11.1
Latency to leave start box in cocaine runway, F2.02.32.8-1.5-1.71.71.71.2-1.2-1.7-1.61.6
Latency to leave start box in cocaine runway, M0.10.10.3-0.5-0.00.00.30.4-0.4-0.1-0.20.2
Std. dev. time between licks in bursts1.82.42.4-1.6-1.51.51.61.6-1.6-1.5-1.61.6
Total sessions with >9 infusions0.10.10.40.2-0.10.10.30.1-0.1-0.2-0.60.6
Short access day 1 total inactive lever presses3.74.85.32.22.3-2.3-2.3-2.02.02.22.1-2.1
Short access day 10 total inactive lever presses0.10.20.4-0.5-0.60.60.40.6-0.6-0.6-0.30.3
Short access day 1 total infusions0.10.10.40.2-0.10.10.30.1-0.1-0.2-0.70.7
Short access day 10 total infusions0.00.00.10.40.1-0.0-0.20.0-0.00.1-0.20.2
Short access total infusions0.40.41.0-0.1-0.60.60.60.5-0.5-0.7-1.01.0
Short access day 1 locomotion0.50.61.11.00.8-0.8-0.7-0.80.80.80.6-0.6
Short access day 10 total locomotion0.00.00.10.30.2-0.2-0.2-0.10.10.20.2-0.2
Short access total locomotion0.20.20.70.90.4-0.4-0.3-0.40.40.30.1-0.1
One hour access (0.3 mA shock)0.20.20.60.70.4-0.4-0.3-0.70.70.30.1-0.1
Compulsive drug intake0.40.50.8-0.7-0.70.70.60.5-0.5-0.7-0.90.9
One hour access (shock baseline)0.71.12.01.41.0-1.0-0.8-1.31.30.90.6-0.6
Social response proportion0.20.20.70.1-0.30.20.5-0.00.0-0.4-0.80.8
Social responses0.60.81.21.10.9-0.9-0.8-1.01.00.80.7-0.7
Social time2.22.94.02.01.7-1.7-1.6-1.91.91.61.4-1.4
Soleus weight0.51.51.6-1.2-1.31.21.21.3-1.3-1.2-1.11.1
Bone: stiffness0.00.00.1-0.1-0.10.10.10.1-0.1-0.1-0.30.3
Tibialis anterior weight0.82.73.51.51.5-1.6-1.6-1.51.51.61.9-1.9
Time to tail flick, vehicle, before self-admin0.90.91.3-0.6-1.11.11.00.7-0.7-1.1-1.11.1
Time to tail flick, vehicle, after self-admin1.01.32.3-0.7-1.21.21.10.8-0.8-1.2-1.51.5
Time to tail flick, test, before self-admin0.20.20.70.80.3-0.3-0.3-0.70.70.2-0.10.1
Time to tail flick, test, after self-admin0.30.30.60.80.4-0.4-0.5-0.80.80.50.4-0.4
Delta time to tail flick, vehicle, before/after SA0.30.30.40.60.6-0.6-0.5-0.60.60.50.3-0.3
Delta time to tail flick, test, before/after SA0.00.00.1-0.3-0.20.20.10.1-0.1-0.10.3-0.3
Tibia length0.61.62.6-1.2-1.11.11.31.0-1.0-1.2-1.61.6
Ambulatory time before self-admin1.11.72.1-1.3-1.31.31.21.5-1.5-1.3-1.21.2
Ambulatory time after self-admin0.00.00.1-0.2-0.10.10.10.3-0.3-0.1-0.10.1
Bone: tissue strength0.40.40.5-0.5-0.70.70.60.6-0.6-0.7-0.60.6
Total heroin consumption1.21.41.81.31.2-1.2-1.3-1.11.11.21.1-1.1
Bone: trabecular number0.10.20.40.50.4-0.3-0.6-0.40.40.30.7-0.7
Bone: trabecular spacing0.00.00.10.10.1-0.1-0.1-0.10.10.10.2-0.2
Bone: trabecular thickness0.00.00.0-0.1-0.0-0.00.10.1-0.1-0.0-0.10.1
Bone: trabecular tissue density0.00.00.00.10.0-0.0-0.1-0.10.10.00.2-0.2
Water consumed over 24 hours2.53.43.6-1.8-1.81.81.91.8-1.8-1.9-1.91.9
Number of responses in last shaping day0.50.51.31.10.4-0.4-0.5-1.11.10.40.2-0.2