Hub : Genes

Ovol3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Ovol3	0.04	0.03	2.9e-04	0.01	0.01	0	0.01	1.2e-02	7.1e-03	1.0e-01	2.6e-02
2	NAcc	gene expression	Ovol3	0.04	0.03	1.4e-05	0.04	0.04	0.04	0.04	7.3e-06	4.5e-05	4.9e-05	3.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.7	1.2	1.2	-1.1	1.1
Area under the delay curve	0.1	0.1	0.1	-0.4	0.1
BMI with tail	0.3	0.9	0.9	1.0	-0.9
BMI without tail	0.0	0.0	0.1	-0.3	0.1
Body weight	2.8	11.7	11.7	-3.4	3.4
Weight adjusted by age	0.2	0.2	0.4	-0.1	0.7
Bone surface	1.5	2.6	2.7	-1.7	1.6
Bone volume	1.6	2.7	2.8	-1.7	1.7
Breakpoint value in progressive ratio session	0.9	1.0	1.4	-1.2	0.7
Number of licking bursts	3.3	3.8	5.0	2.2	-1.6
Context. condit. distance diff. score	0.0	0.0	0.1	0.2	0.0
Locomotion velocity, session 1	0.3	0.3	0.4	0.6	-0.5
Locomotion distance, session 1	0.6	0.8	1.1	-0.7	1.0
Locomotion velocity, session 2	0.7	0.9	1.2	0.7	-1.1
Locomotion distance, session 2	1.6	2.2	2.2	1.5	-1.5
Locomotion velocity, session 3	0.4	0.5	0.7	0.6	-0.9
Locomotion distance, session 3	1.6	1.7	2.1	-1.5	1.2
Stereotopy head waving bouts, day 3	0.5	0.6	0.9	0.6	-0.9
Stereotopy head waving duration, day 3	1.3	1.5	1.9	1.1	-1.4
Locomotion velocity, session 7	0.2	0.3	0.4	-0.4	0.6
Locomotion distance, session 7	0.1	0.2	0.2	-0.4	0.5
Stereotopy head waving bouts, day 7	1.1	1.3	1.5	1.2	-1.0
Stereotopy head waving duration, day 7	2.4	3.0	3.2	1.8	-1.7
Locomotion velocity, session 8	4.3	5.1	5.4	2.3	-2.2
Locomotion distance, session 8	0.9	1.3	1.5	1.2	-1.0
Degree of sensitization distance	0.1	0.1	0.2	0.5	-0.2
Degree of sensitization stereotypy	1.4	1.6	2.0	1.4	-1.1
Conditioned locomotion	0.6	0.7	0.8	0.9	-0.8
Cocaine response after cond. corrected	0.1	0.1	0.2	0.0	-0.4
Cocaine response after cond. not corrected	0.1	0.1	0.1	-0.2	-0.4
Cocaine response before conditioning	1.2	1.4	1.8	-1.4	1.0
Saline control response	0.0	0.0	0.0	-0.2	-0.0
Bone: connectivity density	0.2	0.3	0.4	-0.7	0.4
Bone: cortical apparent density	2.0	2.6	2.9	1.7	-1.5
Bone: cortical area	1.3	1.9	2.3	-1.5	1.3
Bone: cortical porosity	2.1	2.3	2.3	1.5	-1.5
Bone: cortical porosity	2.6	2.9	3.0	1.7	-1.6
Bone: cortical thickness	0.3	0.4	0.6	-0.8	0.5
Bone: cortical thickness	0.5	0.6	0.7	0.8	-0.8
Bone: cortical tissue density	2.3	3.1	3.4	1.8	-1.7
Condit. Reinf. active minus inactive responses	0.3	0.4	0.5	0.5	-0.7
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.4	0.3	-0.7
Condit. Reinf. active responses	2.7	3.3	3.5	1.8	-1.9
Condit. Reinf. inactive responses	2.8	3.3	3.4	1.8	-1.8
Incentive salience index mean	0.4	0.4	0.6	0.5	-0.8
Condit. Reinf. lever presses	0.1	0.1	0.2	0.1	-0.4
Condit. Reinf. active minus inactive responses	1.0	1.2	2.0	-1.4	0.6
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.3	0.1	-0.5
Condit. Reinf. active responses	2.8	3.9	5.0	-2.2	1.6
Condit. Reinf. inactive responses	3.6	4.5	4.8	-2.2	2.0
Condit. Reinf. lever presses	6.9	9.3	11.1	-3.3	2.7
Condit. Reinf. lever reinforcers received	2.9	4.1	5.1	-2.2	1.8
Conditioned reinforcement - actives	0.1	0.1	0.1	0.4	-0.3
Conditioned reinforcement - inactives	0.1	0.1	0.2	-0.3	0.4
Conditioned locomotion	2.6	3.1	3.4	1.8	-1.6
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.3	-0.1
Patch foraging indifference point AUC	0.6	0.7	0.9	0.6	-0.9
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.1	0.2
Delay disc. indifference point, 16s delay	0.3	0.3	0.5	-0.7	0.1
Delay disc. indifference point, 2s delay	0.7	0.8	1.0	-0.8	1.0
Delay disc. indifference point, 24s delay	1.7	1.6	1.9	-1.4	1.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	0.3	-0.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.4	0.2
Indifference point function ln k	0.4	0.5	0.6	-0.8	0.7
Indifference point function log k	0.4	0.5	0.6	-0.8	0.7
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	-0.4	0.1
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	-0.0	-0.5
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	0.2	0.0
Patch foraging total patch changes 24 sec	0.8	0.9	1.2	-0.8	1.1
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	-0.1	-0.3
Patch foraging time to switch 0 sec	0.5	0.7	0.9	0.7	-1.0
Patch foraging water rate 0 sec	0.7	1.2	1.2	1.1	-1.1
Patch foraging water rate 12 sec	0.7	1.1	1.6	-0.7	1.3
Patch foraging water rate 18 sec	0.2	0.2	0.2	0.5	-0.5
Patch foraging water rate 24 sec	0.1	0.1	0.1	0.3	0.3
Patch foraging water rate 6 sec	1.0	1.4	2.0	-0.9	1.4
Seeking ratio, delayed vs. immediate footshock	1.2	1.3	1.8	-0.9	1.4
Distance traveled before self-admin	0.0	0.0	0.0	-0.2	0.1
Distance traveled after self-admin	3.8	4.2	4.5	-2.1	2.0
Extensor digitorum longus weight	0.1	0.4	0.6	0.5	-0.8
Bone: elastic displacement	0.0	0.0	0.0	-0.1	-0.2
Bone: elastic work	1.9	2.5	2.6	-1.6	1.6
Bone: endosteal estimation	1.6	3.6	3.6	-1.9	1.9
Bone: endosteal perimeter	1.4	2.9	3.0	-1.7	1.7
Epididymis fat weight	0.2	0.4	0.7	-0.3	0.8
Delta time in closed arm before/after self-admin	2.8	2.7	2.9	-1.7	1.6
Delta time in open arm before/after self-admin	0.6	0.6	0.7	0.8	-0.7
Diff in mean of infusions in LGA sessions	0.6	0.6	0.8	0.7	-0.9
Delay discount exponential model param	0.1	0.1	0.2	0.5	-0.2
Extinction: sum of active levers before priming	3.9	3.9	4.1	-2.0	1.9
Active lever presses in extinction session 6	3.1	3.0	4.1	-2.0	1.4
Bone: final force	1.6	2.5	2.6	-1.6	1.6
Bone: final moment	2.0	3.3	3.5	-1.9	1.8
Food consumed during 24 hour testing period	0.5	0.6	0.7	-0.8	0.8
Glucose	0.0	0.1	0.1	0.3	-0.2
Heart weight	0.1	0.2	0.2	-0.3	0.5
Delay discount hyperbolic model param	0.1	0.1	0.2	0.4	-0.2
Intermittent access intake day 1-15 change	2.8	2.8	3.4	-1.5	1.8
Intermittent access intake escalation	2.7	2.7	3.3	-1.4	1.8
Intermittent access intake escalation 2	1.8	1.8	1.9	-1.4	1.3
Intermitt. access day 1 inactive lever presses	2.4	2.6	3.6	-1.9	1.3
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.2	-0.4	0.2
Intermitt. access escalation Index	0.1	0.1	0.2	0.4	-0.1
Intermittent access day 1 total infusions	2.4	2.7	3.5	1.9	-1.4
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.4	0.1
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.6	0.7	-0.4
Intermittent access total infusions	0.6	0.6	1.0	1.0	-0.5
Intermittent access day 1 locomotion	1.4	1.4	1.8	1.3	-1.1
Intermittent access day 15 total locomotion	0.1	0.1	0.2	0.4	0.1
Intermittent access total locomotion	1.4	1.6	1.9	1.4	-1.1
Intermittent access standard deviation	5.0	5.3	5.6	-2.2	2.4
Left kidney weight	3.4	9.5	10.2	-3.0	3.2
Right kidney weight	5.7	16.1	16.3	-4.0	4.0
Cocaine induced anxiety	0.4	0.5	0.6	-0.8	0.5
Post-drug Anxiety	0.3	0.3	0.6	0.1	-0.7
Baseline Anxiety	1.8	1.9	2.2	1.3	-1.5
Tail length	5.1	15.4	16.2	-4.0	3.8
Length with tail	8.5	31.2	31.9	-5.7	5.5
Length without tail	5.7	12.5	13.0	-3.4	3.6
Times rat made contact with spout	0.2	0.2	0.3	0.6	-0.0
Lifetime Intake	0.6	0.7	1.1	1.0	-0.6
Liver weight, left	0.2	0.4	0.4	0.6	-0.6
Liver weight, right	0.1	0.2	0.2	0.3	-0.5
Locomotor activity	0.3	0.5	0.7	0.5	-0.8
Locomotor testing distance	0.1	0.2	0.3	0.5	-0.5
Locomotor testing rearing	1.2	1.9	2.7	1.7	-1.0
Locomotion in novel chamber	0.4	0.5	1.0	0.3	-1.0
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.2	-0.4
Fecal boli incidents, locomotor time 1	2.5	2.8	3.7	1.4	-1.9
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.4	-0.0
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.2	-0.2
Bouts of movement, locomotor time 1	0.4	0.4	0.5	-0.6	0.7
Total resting periods, locomotor time 1	0.3	0.3	0.3	-0.6	0.5
Rest time, locomotor task time 1	1.4	1.6	2.2	1.0	-1.5
Distance moved, locomotor task time 1	0.2	0.2	0.3	-0.1	0.6
Vertical activity count, locomotor time 1	2.0	2.1	2.5	-1.3	1.6
Time >=10cm from walls, locomotor time 2	2.2	2.4	2.7	1.4	-1.6
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.0	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	0.1	-0.2
Rest time, locomotor task time 2	0.6	0.7	1.0	0.6	-1.0
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.4	0.1
Vertical activity count, locomotor time 2	0.7	0.8	1.0	-0.8	1.0
Light reinforcement 1	0.2	0.4	0.5	0.5	-0.7
Light reinforcement 2	3.3	4.4	5.1	1.9	-2.3
Bone: marrow area	1.7	3.8	3.8	-2.0	1.9
Bone: maximum diameter	1.3	2.5	2.6	-1.6	1.5
Bone: maximum force	2.5	4.4	4.4	-2.1	2.1
Bone: maximum moment	3.0	5.1	5.3	-2.3	2.2
Mean time between licks in bursts	0.0	0.0	0.0	0.1	-0.0
Mean num. licks in bursts	1.8	2.1	2.3	-1.5	1.4
Cd content in liver	0.2	0.2	0.4	-0.3	0.6
Co content in liver	0.5	0.5	0.7	0.7	-0.8
Cu content in liver	0.6	0.7	1.0	-0.7	1.0
Fe content in liver	0.0	0.0	0.0	0.2	-0.1
K content in liver	0.0	0.0	0.0	-0.1	-0.2
Mg content in liver	0.8	0.8	1.2	0.7	-1.1
Mn content in liver	1.1	1.2	1.6	0.9	-1.3
Na content in liver	1.4	1.4	1.5	-1.2	1.2
Rb content in liver	0.1	0.2	0.2	0.4	-0.3
Se content in liver	7.8	9.6	9.9	3.0	-3.2
Sr content in liver	0.9	0.8	1.0	0.8	-1.0
Zn content in liver	0.1	0.1	0.2	0.4	-0.4
Bone: minimum diameter	2.6	4.9	5.3	-2.3	2.1
Time in familiar zone, hab. session 1	0.6	0.5	0.6	-0.8	0.7
Time in novel zone, hab. session 1	1.9	1.9	2.0	1.4	-1.4
Total zone transitions, hab. session 1	0.0	0.0	0.0	0.2	-0.2
Total locomotion distance, hab. session 1	0.8	1.2	1.4	-1.2	1.0
Locomotion velocity, hab. session 1	0.6	0.8	1.0	-1.0	0.9
Time in familiar zone, hab. session 2	1.8	1.9	2.6	-1.6	1.1
Time in novel zone, hab. session 2	1.3	1.2	1.5	1.2	-1.0
Total zone transitions, hab. session 2	3.5	4.5	4.6	2.1	-2.1
Total locomotion distance, hab. session 2	0.2	0.2	0.3	0.5	-0.4
Locomotion velocity, hab. session 2	0.2	0.3	0.4	0.6	-0.5
Novel to familiar place preference ratio	0.0	0.0	0.1	-0.3	-0.1
Novelty place preference	0.0	0.0	0.0	-0.1	-0.1
Time in novel zone, NPP test	0.0	0.0	0.1	0.1	-0.3
Total zone transitions, NPP test	0.1	0.1	0.1	0.3	-0.3
Total locomotion distance, NPP test	2.4	3.3	3.6	-1.9	1.8
Locomotion velocity, NPP test	2.4	3.4	3.9	-2.0	1.7
Intraocular pressure	0.0	0.0	0.1	0.2	-0.2
Delta distance traveled before/after self-admin	4.3	4.7	4.7	-2.2	2.2
Delta ambulatory time before/after self-admin	5.0	5.5	5.7	-2.3	2.4
Parametrial fat weight	0.0	0.0	0.1	-0.1	-0.2
Pavlov. Cond. lever latency	0.4	0.5	0.7	-0.5	0.8
Pavlov. Cond. magazine entry latency	0.4	0.5	0.5	0.7	-0.7
Pavlov. Cond. change in total contacts	0.7	0.8	1.0	0.7	-1.0
Pavlov. Cond. index score	0.7	0.9	1.2	0.8	-1.1
Pavlov. Cond. latency score	0.4	0.6	0.7	0.6	-0.9
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.0	-0.5
Pavlov. Cond. magazine entry number	0.6	0.7	0.7	-0.8	0.8
Pavlov. Cond. intertrial magazine entries	0.9	1.0	1.2	0.9	-1.1
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	1.4	1.0	-1.2
Pavlov. Cond. response bias	0.3	0.3	0.5	0.3	-0.7
Pavlov. Cond. lever latency	4.5	6.0	6.6	2.6	-2.3
Pavlov. Cond. magazine entry latency	2.4	2.8	3.3	-1.8	1.5
Pavlov. Cond. change in total contacts	7.5	10.3	10.7	-3.3	3.2
Pavlov. Cond. index score	4.8	6.2	6.5	-2.5	2.4
Pavlov. Cond. latency score	4.4	5.4	5.8	-2.4	2.2
Pavlov. Cond. lever contacts	4.1	5.6	5.8	-2.4	2.3
Pavlov. Cond. magazine entry number	4.0	4.9	5.1	2.2	-2.3
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.3	1.1	-1.1
Pavlov. Cond. lever-magazine prob. diff.	4.8	6.1	6.4	-2.5	2.4
Pavlov. Cond. response bias	4.8	6.5	6.6	-2.5	2.6
Time in closed arm before self-admin	2.8	3.2	3.4	1.9	-1.7
Time in closed arm after self-admin	0.0	0.0	0.0	-0.1	-0.2
Time in open arm before self-admin	4.6	5.0	6.0	-2.4	2.0
Time in open arm after self-admin	1.3	1.4	1.5	-1.1	1.2
Bone: periosteal estimation	2.0	4.2	4.5	-2.1	2.0
Bone: periosteal perimeter	1.3	2.1	2.6	-1.6	1.3
Bone: post-yield work	1.4	1.9	2.0	-1.3	1.4
Progressive ratio test 1 active lever presses	0.3	0.3	0.5	-0.4	0.7
Progressive ratio test 1 breakpoint	0.6	0.6	0.8	-0.7	0.9
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.1	-0.3	0.3
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.1	0.3
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.2	0.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.4	0.3
Incentive Sensitization - Responses	0.0	0.0	0.1	0.3	0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.3	0.1
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.2	-0.4	0.4
Progressive ratio	0.0	0.0	0.0	-0.1	-0.1
Food seeking constrained by brief footshock	2.9	3.5	4.2	-2.0	1.7
Seeking ratio, punishment vs. effort	0.5	0.6	0.6	-0.8	0.7
Retroperitoneal fat weight	1.0	3.4	3.5	1.9	-1.8
Reaction time number correct	0.0	0.0	0.0	0.1	0.1
Reaction time mean minus median	0.5	0.6	0.7	-0.8	0.8
Reaction time mean minus median AUC	1.1	1.5	1.7	-1.1	1.3
Reaction time num false alarms	0.7	1.0	1.4	1.2	-0.8
Reaction time num false alarms AUC	1.0	1.3	1.6	1.3	-1.0
Reaction time trials correct on left	0.0	0.0	0.0	0.1	0.1
Reaction time trials on left	0.0	0.0	0.0	0.1	0.1
Reaction time mean	0.4	0.6	1.0	-0.4	1.0
Reaction time mean AUC	0.3	0.4	0.6	-0.3	0.8
Median of all reaction times	0.2	0.3	0.6	-0.1	0.8
Reaction time omissions	0.0	0.0	0.1	0.0	0.3
Reaction time false alarm rate	0.6	0.9	1.0	1.0	-0.8
Reaction time premature initiation rate	0.0	0.0	0.0	-0.0	-0.0
Reaction time premature initiations	0.0	0.0	0.0	0.1	0.0
Std. dev. reaction times	0.8	1.2	1.6	-0.9	1.3
Reaction time trials completed	0.0	0.0	0.0	0.1	0.1
Reaction time trials AUC	0.0	0.0	0.0	0.2	0.0
Run reversals in cocaine runway, females	0.7	0.7	1.1	-0.6	1.1
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.1	-0.4
Latency to leave start box in cocaine runway	0.3	0.3	0.7	-0.1	0.8
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.3	0.2
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	-0.2	0.7
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.2	-0.0
Total sessions with >9 infusions	1.0	1.1	1.4	1.2	-0.9
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.1	0.0
Short access day 10 total inactive lever presses	1.0	1.1	1.4	-1.2	0.9
Short access day 1 total infusions	0.1	0.1	0.2	0.4	-0.2
Short access day 10 total infusions	0.3	0.4	0.6	0.8	-0.5
Short access total infusions	0.7	0.8	1.1	1.1	-0.7
Short access day 1 locomotion	0.3	0.4	0.5	0.7	-0.5
Short access day 10 total locomotion	0.3	0.3	0.3	-0.6	0.5
Short access total locomotion	1.1	1.1	1.1	1.1	-1.1
One hour access (0.3 mA shock)	0.8	0.9	1.2	-0.8	1.1
Compulsive drug intake	0.0	0.0	0.1	-0.2	0.1
One hour access (shock baseline)	0.0	0.0	0.0	0.1	0.2
Social response proportion	1.4	1.5	2.3	-1.5	0.8
Social responses	0.3	0.4	0.8	-0.9	-0.2
Social time	2.2	3.0	3.2	-1.8	1.7
Soleus weight	0.1	0.4	0.5	0.5	-0.7
Bone: stiffness	1.3	2.0	2.0	-1.4	1.4
Tibialis anterior weight	0.0	0.0	0.0	-0.0	-0.2
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.1	1.0	-1.0
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.1	-0.5
Time to tail flick, test, before self-admin	0.4	0.4	0.7	0.8	0.0
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.2	-0.1
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.7	-0.8	0.5
Delta time to tail flick, test, before/after SA	0.3	0.3	0.5	0.0	-0.7
Tibia length	3.1	8.8	9.8	-2.8	3.1
Ambulatory time before self-admin	0.0	0.0	0.0	-0.0	-0.2
Ambulatory time after self-admin	6.9	7.5	7.8	-2.8	2.7
Bone: tissue strength	3.1	3.0	3.4	-1.6	1.8
Total heroin consumption	0.3	0.3	0.4	-0.5	0.6
Bone: trabecular number	1.5	2.4	2.6	-1.5	1.6
Bone: trabecular spacing	0.2	0.2	0.3	-0.6	0.3
Bone: trabecular thickness	0.0	0.0	0.1	0.2	0.2
Bone: trabecular tissue density	1.6	2.3	2.5	1.4	-1.6
Water consumed over 24 hours	0.5	0.5	0.6	-0.7	0.8
Number of responses in last shaping day	0.1	0.1	0.1	0.4	-0.2