Hub : Genes

Osm

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Osm 0.06 0.03 1.4e-06 0.03 0.04 0.03 0.03 5.6e-04 2.5e-05 8.4e-04 3.7e-04
2 IC alternative TSS XM_039091735.2 0.11 0.07 2.7e-03 0.06 0.07 0.06 0.09 1.4e-03 6.2e-04 1.1e-03 1.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.81.52.0-1.41.0
Area under the delay curve8.312.815.03.3-3.9
BMI with tail1.34.54.72.2-2.1
BMI without tail0.21.01.11.0-0.9
Body weight2.812.112.53.5-3.4
Weight adjusted by age0.82.43.31.2-1.8
Bone surface0.00.10.10.2-0.3
Bone volume0.00.10.1-0.30.3
Breakpoint value in progressive ratio session0.10.20.20.4-0.5
Number of licking bursts0.41.32.30.6-1.5
Context. condit. distance diff. score1.31.62.3-1.50.9
Locomotion velocity, session 10.00.00.10.20.2
Locomotion distance, session 10.91.22.1-1.40.5
Locomotion velocity, session 20.91.01.9-0.41.4
Locomotion distance, session 21.11.61.6-1.31.2
Locomotion velocity, session 30.40.50.9-1.00.0
Locomotion distance, session 30.80.90.90.9-0.9
Stereotopy head waving bouts, day 31.72.12.1-1.51.4
Stereotopy head waving duration, day 32.22.72.9-1.71.6
Locomotion velocity, session 70.10.10.10.3-0.2
Locomotion distance, session 70.10.10.2-0.40.1
Stereotopy head waving bouts, day 70.50.60.60.7-0.8
Stereotopy head waving duration, day 70.30.40.50.5-0.7
Locomotion velocity, session 82.32.84.1-1.22.0
Locomotion distance, session 85.78.39.5-3.12.7
Degree of sensitization distance4.75.05.1-2.22.3
Degree of sensitization stereotypy0.70.70.80.8-0.9
Conditioned locomotion0.20.30.4-0.7-0.3
Cocaine response after cond. corrected0.50.80.90.8-1.0
Cocaine response after cond. not corrected1.21.72.21.1-1.5
Cocaine response before conditioning0.10.10.20.0-0.5
Saline control response0.10.10.3-0.50.0
Bone: connectivity density0.30.51.0-1.00.2
Bone: cortical apparent density0.10.20.20.4-0.4
Bone: cortical area2.13.43.61.8-1.9
Bone: cortical porosity0.10.10.20.2-0.5
Bone: cortical porosity0.00.00.1-0.1-0.3
Bone: cortical thickness1.83.03.91.4-2.0
Bone: cortical thickness0.50.60.8-0.7-0.9
Bone: cortical tissue density0.10.20.20.5-0.5
Condit. Reinf. active minus inactive responses0.50.50.50.7-0.7
Condit. Reinf. active-inactive response ratio0.10.10.30.50.1
Condit. Reinf. active responses0.10.10.10.3-0.3
Condit. Reinf. inactive responses0.00.00.0-0.2-0.0
Incentive salience index mean1.11.51.51.2-1.2
Condit. Reinf. lever presses1.11.62.01.1-1.4
Condit. Reinf. active minus inactive responses0.40.61.0-1.00.4
Condit. Reinf. active-inactive response ratio0.30.40.80.2-0.9
Condit. Reinf. active responses0.91.32.0-1.40.7
Condit. Reinf. inactive responses1.62.42.5-1.61.5
Condit. Reinf. lever presses0.10.20.3-0.6-0.0
Condit. Reinf. lever reinforcers received0.50.71.3-1.20.3
Conditioned reinforcement - actives0.41.52.41.6-0.8
Conditioned reinforcement - inactives1.33.55.02.2-1.4
Conditioned locomotion0.50.81.21.1-0.6
Patch foraging indifference point 0 sec0.00.10.20.2-0.4
Patch foraging indifference point AUC0.00.00.1-0.20.2
Delay disc. indifference point, 0s delay7.88.810.32.7-3.2
Delay disc. indifference point, 16s delay5.47.78.72.6-3.0
Delay disc. indifference point, 2s delay6.87.69.32.4-3.0
Delay disc. indifference point, 24s delay5.79.112.42.4-3.5
Delay disc. indifference point, 4s delay5.25.56.72.1-2.6
Delay disc. indifference point, 8s delay1.62.73.01.7-1.6
Indifference point function ln k0.10.30.5-0.70.3
Indifference point function log k0.10.30.5-0.70.3
Patch foraging total patch changes 0 sec0.10.20.20.4-0.4
Patch foraging total patch changes 12 sec0.10.10.10.2-0.4
Patch foraging total patch changes 18 sec0.30.61.21.1-0.2
Patch foraging total patch changes 24 sec0.20.71.0-1.00.6
Patch foraging total patch changes 6 sec0.10.10.20.3-0.4
Patch foraging time to switch 0 sec0.10.30.5-0.00.7
Patch foraging water rate 0 sec0.10.40.60.7-0.5
Patch foraging water rate 12 sec0.10.20.4-0.20.6
Patch foraging water rate 18 sec0.92.03.3-1.80.9
Patch foraging water rate 24 sec0.91.32.5-0.31.6
Patch foraging water rate 6 sec0.40.61.0-0.41.0
Seeking ratio, delayed vs. immediate footshock0.10.20.3-0.50.4
Distance traveled before self-admin0.10.10.1-0.40.3
Distance traveled after self-admin0.00.10.1-0.1-0.3
Extensor digitorum longus weight1.76.87.32.7-2.5
Bone: elastic displacement0.50.60.7-0.80.7
Bone: elastic work0.20.20.3-0.50.5
Bone: endosteal estimation0.10.30.5-0.20.7
Bone: endosteal perimeter0.20.60.80.9-0.6
Epididymis fat weight0.52.52.61.6-1.5
Delta time in closed arm before/after self-admin2.32.13.9-2.00.6
Delta time in open arm before/after self-admin4.25.07.32.7-1.6
Diff in mean of infusions in LGA sessions0.10.10.30.2-0.5
Delay discount exponential model param8.912.114.2-3.23.8
Extinction: sum of active levers before priming2.03.14.21.4-2.1
Active lever presses in extinction session 60.20.30.40.7-0.3
Bone: final force0.10.20.30.6-0.2
Bone: final moment0.10.10.20.4-0.1
Food consumed during 24 hour testing period0.10.20.20.4-0.5
Glucose11.017.428.85.4-2.5
Heart weight0.61.01.21.1-0.9
Delay discount hyperbolic model param9.412.114.1-3.23.7
Intermittent access intake day 1-15 change0.21.01.91.40.4
Intermittent access intake escalation0.21.01.91.4-0.1
Intermittent access intake escalation 20.20.40.40.60.7
Intermitt. access day 1 inactive lever presses0.00.50.90.4-0.9
Intermitt. access day 15 inactive lever presses0.73.74.11.8-2.0
Intermitt. access escalation Index0.10.20.4-0.1-0.6
Intermittent access day 1 total infusions0.61.72.11.4-1.1
Intermittent access day 15 total infusions1.12.85.02.2-0.8
Intermittent access terminal intake (last 3 days)0.81.32.71.6-0.1
Intermittent access total infusions1.21.42.71.6-0.3
Intermittent access day 1 locomotion0.10.10.1-0.30.3
Intermittent access day 15 total locomotion1.03.74.72.2-1.7
Intermittent access total locomotion1.31.51.91.4-1.0
Intermittent access standard deviation0.00.20.30.20.6
Left kidney weight0.00.10.2-0.4-0.2
Right kidney weight0.10.50.6-0.5-0.8
Cocaine induced anxiety0.92.32.41.5-1.5
Post-drug Anxiety3.43.94.31.9-2.1
Baseline Anxiety0.10.20.40.6-0.2
Tail length0.10.70.90.9-0.6
Length with tail0.41.92.21.5-1.3
Length without tail0.41.92.31.3-1.5
Times rat made contact with spout0.10.10.20.3-0.5
Lifetime Intake0.81.02.01.4-0.2
Liver weight, left0.40.61.2-1.10.3
Liver weight, right0.50.81.2-1.10.7
Locomotor activity0.40.70.90.71.0
Locomotor testing distance0.10.20.40.60.1
Locomotor testing rearing0.31.22.11.5-0.6
Locomotion in novel chamber0.30.40.7-0.8-0.2
Locomotion in novel chamber post-restriction0.20.50.5-0.70.6
Fecal boli incidents, locomotor time 10.20.40.4-0.60.7
Change in fecal boli incidents, locomotor task0.10.20.3-0.10.5
Time >=10cm from walls, locomotor time 10.40.50.90.30.9
Bouts of movement, locomotor time 10.60.81.00.8-1.0
Total resting periods, locomotor time 11.11.21.41.0-1.2
Rest time, locomotor task time 10.30.51.00.2-1.0
Distance moved, locomotor task time 10.30.71.3-0.31.2
Vertical activity count, locomotor time 10.21.32.4-0.51.5
Time >=10cm from walls, locomotor time 20.10.30.5-0.30.7
Bouts of movement, locomotor time 20.00.10.20.2-0.4
Total resting periods, locomotor time 20.10.40.70.4-0.8
Rest time, locomotor task time 20.10.10.2-0.5-0.0
Distance moved, locomotor task time 20.10.10.2-0.20.4
Vertical activity count, locomotor time 20.00.00.0-0.1-0.0
Light reinforcement 10.10.20.30.4-0.5
Light reinforcement 20.10.20.4-0.30.6
Bone: marrow area0.10.20.4-0.20.6
Bone: maximum diameter2.44.86.52.6-1.7
Bone: maximum force0.00.00.00.10.0
Bone: maximum moment0.00.00.1-0.00.2
Mean time between licks in bursts0.00.00.1-0.3-0.0
Mean num. licks in bursts0.20.71.2-0.41.1
Cd content in liver0.30.30.70.8-0.0
Co content in liver0.60.71.00.7-1.0
Cu content in liver0.30.40.60.4-0.8
Fe content in liver0.20.20.5-0.70.1
K content in liver3.53.55.21.3-2.3
Mg content in liver3.43.74.61.7-2.1
Mn content in liver0.00.00.0-0.1-0.1
Na content in liver6.06.77.32.5-2.7
Rb content in liver0.80.91.00.9-1.0
Se content in liver1.72.02.61.2-1.6
Sr content in liver1.81.62.71.7-0.6
Zn content in liver0.10.10.2-0.20.5
Bone: minimum diameter0.10.30.3-0.50.5
Time in familiar zone, hab. session 11.11.21.6-0.91.3
Time in novel zone, hab. session 10.30.30.50.4-0.7
Total zone transitions, hab. session 10.30.40.6-0.50.7
Total locomotion distance, hab. session 10.00.00.1-0.10.3
Locomotion velocity, hab. session 10.00.00.00.00.2
Time in familiar zone, hab. session 22.22.53.1-1.81.4
Time in novel zone, hab. session 21.41.52.31.5-0.8
Total zone transitions, hab. session 20.10.10.20.50.0
Total locomotion distance, hab. session 20.30.40.70.90.1
Locomotion velocity, hab. session 20.40.61.11.1-0.2
Novel to familiar place preference ratio2.43.23.31.8-1.7
Novelty place preference2.22.82.91.7-1.6
Time in novel zone, NPP test1.92.32.51.6-1.5
Total zone transitions, NPP test0.10.20.3-0.5-0.3
Total locomotion distance, NPP test0.10.20.30.0-0.6
Locomotion velocity, NPP test0.30.40.70.3-0.9
Intraocular pressure0.30.40.60.80.6
Delta distance traveled before/after self-admin0.20.20.20.5-0.5
Delta ambulatory time before/after self-admin0.00.00.1-0.1-0.3
Parametrial fat weight2.66.19.93.1-1.5
Pavlov. Cond. lever latency0.00.00.00.20.0
Pavlov. Cond. magazine entry latency0.91.21.5-1.20.9
Pavlov. Cond. change in total contacts1.01.11.31.1-1.0
Pavlov. Cond. index score0.40.60.9-1.00.4
Pavlov. Cond. latency score0.50.60.9-0.90.5
Pavlov. Cond. lever contacts0.10.20.3-0.50.2
Pavlov. Cond. magazine entry number0.40.50.80.9-0.5
Pavlov. Cond. intertrial magazine entries0.40.51.1-0.1-1.0
Pavlov. Cond. lever-magazine prob. diff.0.60.71.2-1.10.4
Pavlov. Cond. response bias0.10.10.2-0.5-0.1
Pavlov. Cond. lever latency0.71.01.10.9-1.0
Pavlov. Cond. magazine entry latency0.10.20.30.3-0.5
Pavlov. Cond. change in total contacts0.10.20.2-0.50.3
Pavlov. Cond. index score0.10.20.3-0.50.4
Pavlov. Cond. latency score0.20.40.5-0.70.4
Pavlov. Cond. lever contacts0.71.01.1-1.10.9
Pavlov. Cond. magazine entry number0.00.00.0-0.1-0.1
Pavlov. Cond. intertrial magazine entries0.00.10.1-0.30.2
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.70.5
Pavlov. Cond. response bias0.20.30.4-0.60.6
Time in closed arm before self-admin0.40.61.0-1.00.5
Time in closed arm after self-admin2.12.44.4-2.10.6
Time in open arm before self-admin0.10.20.3-0.10.6
Time in open arm after self-admin1.61.73.41.8-0.3
Bone: periosteal estimation0.20.40.60.8-0.6
Bone: periosteal perimeter1.63.23.21.8-1.8
Bone: post-yield work0.10.20.3-0.30.6
Progressive ratio test 1 active lever presses1.12.02.01.4-1.4
Progressive ratio test 1 breakpoint1.22.12.21.5-1.5
Progressive ratio test 1 inactive lever presses1.94.95.22.3-2.1
Progressive ratio test 2 active lever presses1.11.62.81.7-0.6
Progressive ratio test 2 breakpoint1.21.52.71.6-0.5
Progressive ratio test 2 inactive lever presses1.75.47.72.8-1.7
Incentive Sensitization - Responses0.41.12.01.4-0.4
Incentive Sensitization - Breakpoint0.40.91.81.3-0.2
Sum of active levers in priming session hrs 5-60.60.60.60.7-0.8
Progressive ratio0.00.10.10.20.3
Food seeking constrained by brief footshock2.73.44.91.4-2.2
Seeking ratio, punishment vs. effort0.40.81.60.3-1.3
Retroperitoneal fat weight0.83.85.92.4-1.3
Reaction time number correct0.41.42.4-0.71.6
Reaction time mean minus median0.00.20.30.5-0.4
Reaction time mean minus median AUC0.10.50.70.8-0.6
Reaction time num false alarms0.71.21.61.0-1.2
Reaction time num false alarms AUC0.30.60.80.7-0.9
Reaction time trials correct on left0.41.42.4-0.71.6
Reaction time trials on left0.41.52.6-0.71.6
Reaction time mean0.00.00.00.10.2
Reaction time mean AUC0.00.10.1-0.00.4
Median of all reaction times0.10.10.2-0.10.4
Reaction time omissions0.00.10.1-0.30.2
Reaction time false alarm rate1.42.03.01.0-1.7
Reaction time premature initiation rate2.03.15.0-2.21.1
Reaction time premature initiations1.23.74.4-2.11.8
Std. dev. reaction times0.10.20.50.7-0.1
Reaction time trials completed0.41.52.6-0.71.6
Reaction time trials AUC0.41.42.3-0.71.5
Run reversals in cocaine runway, females0.00.00.00.10.0
Run reversals in cocaine runway, males0.10.10.20.0-0.5
Latency to leave start box in cocaine runway0.20.30.60.2-0.7
Latency to leave start box in cocaine runway, F0.30.40.50.5-0.7
Latency to leave start box in cocaine runway, M0.30.30.5-0.0-0.7
Std. dev. time between licks in bursts0.30.51.0-1.00.0
Total sessions with >9 infusions0.10.10.2-0.40.3
Short access day 1 total inactive lever presses0.81.62.01.4-1.1
Short access day 10 total inactive lever presses0.00.00.0-0.2-0.1
Short access day 1 total infusions0.20.30.5-0.40.7
Short access day 10 total infusions0.10.20.3-0.20.6
Short access total infusions0.10.10.30.10.5
Short access day 1 locomotion0.91.61.8-1.41.1
Short access day 10 total locomotion0.72.84.4-2.11.1
Short access total locomotion2.23.34.6-2.11.4
One hour access (0.3 mA shock)0.80.91.81.30.3
Compulsive drug intake1.21.83.4-1.80.5
One hour access (shock baseline)1.12.95.52.3-0.5
Social response proportion0.10.10.20.40.1
Social responses0.20.20.50.7-0.0
Social time0.20.20.3-0.60.4
Soleus weight0.00.10.10.30.1
Bone: stiffness0.10.20.30.0-0.6
Tibialis anterior weight1.24.04.52.1-1.9
Time to tail flick, vehicle, before self-admin0.10.10.10.20.3
Time to tail flick, vehicle, after self-admin0.00.00.0-0.0-0.1
Time to tail flick, test, before self-admin0.40.50.8-0.90.5
Time to tail flick, test, after self-admin0.50.50.60.6-0.8
Delta time to tail flick, vehicle, before/after SA0.00.00.0-0.2-0.2
Delta time to tail flick, test, before/after SA0.60.71.01.0-0.7
Tibia length0.20.61.1-1.00.3
Ambulatory time before self-admin0.00.10.1-0.10.3
Ambulatory time after self-admin0.00.10.1-0.30.1
Bone: tissue strength2.02.13.4-0.81.9
Total heroin consumption0.50.60.7-0.70.8
Bone: trabecular number0.30.61.0-1.00.4
Bone: trabecular spacing0.60.91.71.3-0.2
Bone: trabecular thickness1.82.53.7-1.91.2
Bone: trabecular tissue density0.00.00.00.20.1
Water consumed over 24 hours0.20.40.5-0.50.7
Number of responses in last shaping day0.20.30.40.4-0.6