Hub : Genes

Osm

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Osm	0.03	0.02	2.3e-03	0.03	0.02	0.03	0.03	8.3e-05	7.1e-04	2.2e-04	9.6e-05
2	Brain	alternative TSS	XM_006251200.3	0.04	0.04	7.3e-03	0.03	0.02	0.02	0.03	1.1e-03	7.5e-03	4.7e-03	1.2e-03
3	Adipose	gene expression	Osm	0.04	0.03	2.1e-04	0.01	0.02	0.02	0.01	6.5e-02	1.3e-03	5.5e-03	1.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.7	1.1	1.6	1.0	-0.8	-1.3
Area under the delay curve	9.6	10.1	10.6	-3.3	3.2	3.1
BMI with tail	0.5	1.6	3.4	-0.8	0.9	1.9
BMI without tail	0.0	0.1	0.1	-0.2	0.1	0.3
Body weight	1.2	5.2	5.8	-2.3	2.4	2.1
Weight adjusted by age	0.6	0.6	0.8	-0.7	0.8	0.9
Bone surface	0.1	0.2	0.4	-0.4	0.7	0.4
Bone volume	0.0	0.0	0.1	-0.1	0.3	-0.1
Breakpoint value in progressive ratio session	0.3	0.3	0.6	-0.8	0.1	0.5
Number of licking bursts	1.1	1.2	2.2	-1.5	1.2	0.2
Context. condit. distance diff. score	2.5	3.0	3.7	1.9	-1.9	-1.3
Locomotion velocity, session 1	0.1	0.1	0.3	0.2	-0.1	0.6
Locomotion distance, session 1	2.0	2.6	3.8	1.9	-1.6	-1.2
Locomotion velocity, session 2	0.0	0.0	0.1	-0.1	-0.3	0.0
Locomotion distance, session 2	1.2	1.7	2.6	1.6	-1.5	-0.6
Locomotion velocity, session 3	1.2	1.4	2.2	1.5	-1.2	-0.7
Locomotion distance, session 3	0.6	0.7	1.1	-0.6	0.8	1.1
Stereotopy head waving bouts, day 3	1.9	2.2	2.7	1.6	-1.4	-1.4
Stereotopy head waving duration, day 3	3.0	3.6	4.7	2.2	-2.0	-1.5
Locomotion velocity, session 7	0.0	0.1	0.1	-0.0	0.3	0.3
Locomotion distance, session 7	0.5	0.6	1.2	1.1	-0.7	-0.2
Stereotopy head waving bouts, day 7	0.0	0.1	0.2	0.0	0.0	0.4
Stereotopy head waving duration, day 7	0.1	0.2	0.3	-0.3	0.4	0.5
Locomotion velocity, session 8	1.0	1.2	1.7	1.0	-1.3	-0.9
Locomotion distance, session 8	7.2	10.6	12.8	3.6	-3.6	-2.5
Degree of sensitization distance	5.4	5.4	5.9	2.4	-2.4	-2.1
Degree of sensitization stereotypy	0.5	0.5	0.6	-0.8	0.7	0.7
Conditioned locomotion	0.3	0.4	0.6	0.8	-0.6	-0.3
Cocaine response after cond. corrected	0.6	0.7	1.1	-0.7	1.1	0.7
Cocaine response after cond. not corrected	1.1	1.2	1.9	-1.1	1.4	0.7
Cocaine response before conditioning	0.0	0.0	0.1	-0.0	-0.1	-0.4
Saline control response	0.9	1.2	2.2	1.5	-1.1	-0.2
Bone: connectivity density	0.5	0.7	1.0	1.0	-0.7	-0.9
Bone: cortical apparent density	0.0	0.0	0.1	-0.2	0.1	0.3
Bone: cortical area	2.1	3.2	4.2	-1.8	2.0	1.4
Bone: cortical porosity	0.2	0.2	0.4	-0.6	0.6	-0.0
Bone: cortical porosity	0.1	0.1	0.1	-0.3	0.3	-0.1
Bone: cortical thickness	1.2	2.0	2.9	-1.4	1.7	1.1
Bone: cortical thickness	0.3	0.3	0.6	0.8	-0.5	-0.4
Bone: cortical tissue density	0.1	0.1	0.1	-0.3	0.1	0.4
Condit. Reinf. active minus inactive responses	0.3	0.4	0.9	0.2	0.4	0.9
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.9	0.3	-0.0	1.0
Condit. Reinf. active responses	0.1	0.2	0.3	0.6	0.0	0.4
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.1	-0.0	-0.5
Incentive salience index mean	0.7	0.8	1.6	-0.3	0.9	1.3
Condit. Reinf. lever presses	0.4	0.5	0.8	-0.3	0.8	0.9
Condit. Reinf. active minus inactive responses	0.8	1.0	1.2	1.1	-1.0	-0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.2	0.1	0.4
Condit. Reinf. active responses	1.8	2.5	3.4	1.8	-1.7	-1.1
Condit. Reinf. inactive responses	2.4	3.0	3.5	1.9	-1.9	-1.4
Condit. Reinf. lever presses	0.5	0.7	1.1	1.0	-0.9	-0.5
Condit. Reinf. lever reinforcers received	1.5	2.1	3.1	1.8	-1.5	-0.9
Conditioned reinforcement - actives	2.2	2.2	2.8	-1.2	1.7	1.6
Conditioned reinforcement - inactives	2.8	3.2	3.8	-1.6	1.9	1.8
Conditioned locomotion	0.3	0.4	0.6	-0.7	0.7	0.3
Patch foraging indifference point 0 sec	0.0	0.1	0.2	-0.4	0.2	0.1
Patch foraging indifference point AUC	0.2	0.2	0.5	0.5	-0.7	-0.1
Delay disc. indifference point, 0s delay	6.6	7.2	8.7	-2.5	2.6	3.0
Delay disc. indifference point, 16s delay	6.7	6.7	7.2	-2.7	2.5	2.6
Delay disc. indifference point, 2s delay	5.2	5.7	6.7	-2.3	2.6	2.3
Delay disc. indifference point, 24s delay	5.6	5.5	6.3	-2.1	2.4	2.5
Delay disc. indifference point, 4s delay	5.0	5.2	6.3	-2.3	2.5	2.0
Delay disc. indifference point, 8s delay	2.5	2.5	3.1	-1.8	1.4	1.7
Indifference point function ln k	0.3	0.4	0.8	0.5	-0.0	-0.9
Indifference point function log k	0.3	0.4	0.8	0.5	-0.0	-0.9
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.6	0.4	0.3
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	-0.3	-0.0	0.2
Patch foraging total patch changes 18 sec	0.9	1.2	1.6	-1.2	0.7	1.3
Patch foraging total patch changes 24 sec	1.7	2.0	3.4	1.6	-1.8	-0.5
Patch foraging total patch changes 6 sec	0.0	0.1	0.1	-0.3	0.1	0.3
Patch foraging time to switch 0 sec	0.0	0.0	0.1	-0.3	-0.1	0.1
Patch foraging water rate 0 sec	0.1	0.2	0.2	-0.5	0.5	0.3
Patch foraging water rate 12 sec	0.1	0.2	0.3	0.5	-0.2	-0.4
Patch foraging water rate 18 sec	2.4	3.2	4.9	1.7	-1.4	-2.2
Patch foraging water rate 24 sec	0.2	0.2	0.5	0.3	-0.3	-0.7
Patch foraging water rate 6 sec	0.2	0.3	0.7	0.4	-0.0	-0.8
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.3	0.1	-0.5	-0.6
Distance traveled before self-admin	0.0	0.0	0.1	-0.1	-0.3	-0.1
Distance traveled after self-admin	0.3	0.3	0.4	-0.7	0.2	0.7
Extensor digitorum longus weight	1.9	7.6	10.8	-2.8	3.3	2.1
Bone: elastic displacement	0.7	0.8	1.5	0.7	-0.7	-1.2
Bone: elastic work	0.4	0.5	1.4	0.2	-0.2	-1.2
Bone: endosteal estimation	0.0	0.0	0.0	-0.1	0.1	-0.2
Bone: endosteal perimeter	0.6	1.1	1.4	-1.2	1.2	0.8
Epididymis fat weight	0.0	0.1	0.3	-0.5	0.1	-0.1
Delta time in closed arm before/after self-admin	5.6	5.5	7.0	2.3	-2.7	-2.0
Delta time in open arm before/after self-admin	6.9	6.6	8.4	-2.9	2.3	2.5
Diff in mean of infusions in LGA sessions	0.3	0.4	0.6	-0.6	-0.4	0.8
Delay discount exponential model param	8.9	9.3	9.7	3.1	-3.0	-3.0
Extinction: sum of active levers before priming	1.8	1.8	2.8	-1.2	1.1	1.7
Active lever presses in extinction session 6	1.5	1.5	2.6	-1.1	1.6	0.7
Bone: final force	0.1	0.1	0.2	-0.4	0.4	0.4
Bone: final moment	0.1	0.2	0.4	-0.6	0.5	0.2
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.5	0.3	0.3
Glucose	18.2	27.5	29.3	-5.4	4.9	5.4
Heart weight	0.2	0.3	0.4	0.7	-0.6	-0.2
Delay discount hyperbolic model param	9.1	9.7	9.8	3.1	-3.1	-3.1
Intermittent access intake day 1-15 change	1.3	1.2	1.9	-1.0	0.9	1.4
Intermittent access intake escalation	0.7	0.7	1.1	-0.8	0.6	1.0
Intermittent access intake escalation 2	0.0	0.0	0.1	-0.3	-0.0	0.0
Intermitt. access day 1 inactive lever presses	0.6	0.7	1.5	1.2	-0.6	-0.4
Intermitt. access day 15 inactive lever presses	0.8	0.9	1.5	-0.6	0.9	1.2
Intermitt. access escalation Index	0.1	0.1	0.2	0.4	-0.3	0.3
Intermittent access day 1 total infusions	0.6	0.7	1.0	-1.0	0.6	0.9
Intermittent access day 15 total infusions	2.3	2.6	3.1	-1.6	1.4	1.8
Intermittent access terminal intake (last 3 days)	0.8	0.9	1.2	-1.1	0.7	1.0
Intermittent access total infusions	0.9	1.0	1.4	-1.2	0.9	0.9
Intermittent access day 1 locomotion	0.6	0.6	1.0	0.7	-1.0	-0.6
Intermittent access day 15 total locomotion	2.8	3.0	3.8	-1.9	1.4	1.9
Intermittent access total locomotion	1.0	1.2	1.6	-1.3	0.6	1.2
Intermittent access standard deviation	0.4	0.4	0.5	0.7	-0.7	-0.5
Left kidney weight	0.7	1.9	2.8	1.3	-1.1	-1.7
Right kidney weight	1.0	2.7	3.1	1.7	-1.5	-1.8
Cocaine induced anxiety	0.6	0.7	1.1	-1.1	0.7	0.8
Post-drug Anxiety	0.6	0.7	0.9	-0.9	0.8	0.7
Baseline Anxiety	0.9	1.0	1.2	-0.9	1.1	0.9
Tail length	0.2	0.6	0.7	-0.8	0.9	-0.7
Length with tail	0.5	2.0	3.0	-1.7	1.7	0.1
Length without tail	1.1	2.4	3.0	-1.7	1.7	1.1
Times rat made contact with spout	0.2	0.3	0.4	-0.6	0.2	0.6
Lifetime Intake	0.7	0.8	1.0	-1.0	0.9	0.7
Liver weight, left	5.2	8.4	8.7	2.9	-2.8	-3.0
Liver weight, right	4.8	8.0	9.7	3.1	-2.7	-2.6
Locomotor activity	0.6	0.9	1.6	-1.2	1.0	0.5
Locomotor testing distance	0.2	0.3	0.5	-0.6	0.7	-0.1
Locomotor testing rearing	1.6	2.5	3.5	-1.6	1.9	1.2
Locomotion in novel chamber	0.6	0.7	0.9	1.0	-0.8	-0.7
Locomotion in novel chamber post-restriction	0.8	0.9	1.6	1.1	-1.3	-0.1
Fecal boli incidents, locomotor time 1	0.5	0.6	0.7	0.8	-0.8	-0.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.2	-0.4	-0.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.0	-0.3	0.4
Bouts of movement, locomotor time 1	0.4	0.5	1.1	-0.2	0.6	1.0
Total resting periods, locomotor time 1	0.8	0.9	1.9	-0.4	0.8	1.4
Rest time, locomotor task time 1	0.1	0.1	0.2	0.4	0.1	0.3
Distance moved, locomotor task time 1	0.2	0.2	0.4	-0.3	-0.2	-0.6
Vertical activity count, locomotor time 1	0.2	0.2	0.2	-0.5	-0.3	-0.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	0.1	-0.5	-0.3
Bouts of movement, locomotor time 2	0.1	0.1	0.2	0.4	-0.2	0.2
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.4	-0.1	0.5
Rest time, locomotor task time 2	0.4	0.4	0.9	0.9	-0.5	-0.4
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.2	-0.2	-0.2
Vertical activity count, locomotor time 2	0.1	0.1	0.3	-0.6	0.1	0.1
Light reinforcement 1	0.0	0.0	0.1	0.3	0.2	0.1
Light reinforcement 2	0.2	0.3	0.4	0.4	-0.5	-0.6
Bone: marrow area	0.0	0.0	0.0	-0.1	0.1	-0.2
Bone: maximum diameter	3.5	6.3	7.2	-2.6	2.7	2.2
Bone: maximum force	0.0	0.1	0.1	-0.4	0.2	-0.1
Bone: maximum moment	0.1	0.2	0.3	-0.6	0.3	-0.3
Mean time between licks in bursts	0.0	0.1	0.1	0.1	-0.3	-0.2
Mean num. licks in bursts	0.6	0.7	1.0	1.0	-1.0	0.2
Cd content in liver	1.2	1.3	1.7	1.3	-1.2	-0.9
Co content in liver	0.1	0.2	0.3	-0.1	0.4	0.5
Cu content in liver	0.0	0.0	0.1	0.1	0.2	0.3
Fe content in liver	0.1	0.2	0.4	0.3	-0.6	-0.1
K content in liver	0.4	0.4	0.9	-0.4	0.9	0.4
Mg content in liver	1.5	1.6	2.3	-1.1	1.5	1.1
Mn content in liver	0.0	0.1	0.1	0.1	0.2	-0.3
Na content in liver	7.0	7.4	8.1	-2.6	2.8	2.7
Rb content in liver	0.9	1.1	1.5	-1.0	1.2	0.9
Se content in liver	1.2	1.5	2.1	-1.3	1.5	0.7
Sr content in liver	1.2	1.1	1.7	-1.3	0.9	0.9
Zn content in liver	0.1	0.2	0.3	-0.4	0.2	-0.6
Bone: minimum diameter	0.1	0.2	0.4	0.3	-0.3	-0.6
Time in familiar zone, hab. session 1	0.5	0.5	0.8	0.5	-0.9	-0.7
Time in novel zone, hab. session 1	0.3	0.2	0.5	-0.5	0.7	0.0
Total zone transitions, hab. session 1	0.2	0.3	0.4	0.6	-0.6	-0.3
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	-0.0	0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.4	-0.2	0.2
Time in familiar zone, hab. session 2	3.2	3.3	4.3	1.8	-2.1	-1.4
Time in novel zone, hab. session 2	2.4	2.4	3.0	-1.7	1.7	1.0
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.2	0.3	0.5
Total locomotion distance, hab. session 2	0.4	0.6	0.7	-0.7	0.7	0.8
Locomotion velocity, hab. session 2	0.7	0.9	1.1	-0.9	0.9	1.0
Novel to familiar place preference ratio	2.7	2.8	4.1	-1.3	1.6	2.0
Novelty place preference	2.3	2.4	3.3	-1.2	1.5	1.8
Time in novel zone, NPP test	1.9	2.0	2.7	-1.1	1.4	1.6
Total zone transitions, NPP test	0.3	0.5	0.8	0.9	-0.6	-0.5
Total locomotion distance, NPP test	0.0	0.0	0.1	0.3	-0.0	0.1
Locomotion velocity, NPP test	0.1	0.1	0.2	0.0	0.3	0.5
Intraocular pressure	0.3	0.4	0.8	-0.5	0.5	0.9
Delta distance traveled before/after self-admin	0.6	0.7	0.8	-0.7	0.8	0.9
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	-0.2	0.3	0.4
Parametrial fat weight	1.9	3.7	6.2	-1.4	1.7	2.5
Pavlov. Cond. lever latency	0.4	0.5	0.7	-0.8	0.7	0.5
Pavlov. Cond. magazine entry latency	1.0	1.3	1.5	1.2	-1.2	-0.9
Pavlov. Cond. change in total contacts	1.1	1.2	1.4	-1.0	1.0	1.2
Pavlov. Cond. index score	1.1	1.4	1.9	1.4	-1.3	-0.8
Pavlov. Cond. latency score	1.1	1.4	1.8	1.3	-1.3	-0.9
Pavlov. Cond. lever contacts	0.5	0.5	0.7	0.8	-0.8	-0.5
Pavlov. Cond. magazine entry number	0.9	1.1	1.4	-1.2	1.2	0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.4	0.2	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	2.0	1.4	-1.4	-0.9
Pavlov. Cond. response bias	0.2	0.2	0.3	0.6	-0.5	-0.2
Pavlov. Cond. lever latency	1.2	1.6	2.5	-1.4	1.6	0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.4	0.3	0.1
Pavlov. Cond. change in total contacts	0.4	0.5	0.8	0.8	-0.9	-0.4
Pavlov. Cond. index score	0.6	0.7	1.1	0.9	-1.0	-0.5
Pavlov. Cond. latency score	0.6	0.8	1.1	0.9	-1.1	-0.6
Pavlov. Cond. lever contacts	1.4	2.0	2.9	1.6	-1.7	-0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.5	-0.2	-0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	0.6	-0.3	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.1	0.9	-1.1	-0.6
Pavlov. Cond. response bias	0.4	0.5	1.0	0.7	-1.0	-0.3
Time in closed arm before self-admin	0.3	0.3	0.6	0.3	-0.5	-0.8
Time in closed arm after self-admin	4.9	5.0	5.8	2.0	-2.4	-2.3
Time in open arm before self-admin	0.2	0.2	0.5	0.7	-0.1	-0.3
Time in open arm after self-admin	1.7	1.9	3.0	-1.2	1.1	1.7
Bone: periosteal estimation	0.5	1.0	1.3	-1.1	1.2	0.6
Bone: periosteal perimeter	2.1	3.5	4.1	-1.9	2.0	1.6
Bone: post-yield work	0.2	0.3	0.7	-0.8	0.4	-0.1
Progressive ratio test 1 active lever presses	2.0	2.1	2.4	-1.3	1.4	1.6
Progressive ratio test 1 breakpoint	1.4	1.5	1.9	-1.0	1.2	1.4
Progressive ratio test 1 inactive lever presses	2.7	3.0	3.6	-1.7	1.9	1.6
Progressive ratio test 2 active lever presses	1.8	1.9	2.1	-1.5	1.4	1.3
Progressive ratio test 2 breakpoint	1.7	2.0	2.0	-1.4	1.4	1.4
Progressive ratio test 2 inactive lever presses	4.1	4.7	5.8	-2.2	1.8	2.4
Incentive Sensitization - Responses	1.6	1.6	1.8	-1.3	1.2	1.2
Incentive Sensitization - Breakpoint	1.6	1.6	1.8	-1.4	1.3	1.2
Sum of active levers in priming session hrs 5-6	1.3	1.3	1.6	-1.1	1.3	1.0
Progressive ratio	0.4	0.5	1.2	-1.1	0.6	0.2
Food seeking constrained by brief footshock	2.6	3.2	4.5	-1.9	2.1	1.1
Seeking ratio, punishment vs. effort	0.2	0.2	0.5	0.0	0.7	0.4
Retroperitoneal fat weight	0.1	0.4	1.1	-0.2	0.3	1.0
Reaction time number correct	0.2	0.3	0.6	0.1	-0.5	-0.8
Reaction time mean minus median	0.1	0.1	0.3	-0.5	0.1	0.3
Reaction time mean minus median AUC	0.2	0.2	0.3	-0.6	0.4	0.5
Reaction time num false alarms	0.5	0.7	1.1	-0.6	0.9	1.1
Reaction time num false alarms AUC	0.3	0.4	0.6	-0.4	0.8	0.7
Reaction time trials correct on left	0.2	0.3	0.6	0.1	-0.5	-0.8
Reaction time trials on left	0.2	0.3	0.7	0.2	-0.5	-0.8
Reaction time mean	0.0	0.0	0.0	0.0	-0.1	0.0
Reaction time mean AUC	0.0	0.1	0.1	0.2	-0.3	-0.2
Median of all reaction times	0.0	0.0	0.1	0.3	-0.2	-0.1
Reaction time omissions	0.1	0.1	0.2	0.5	-0.4	-0.1
Reaction time false alarm rate	0.5	0.7	1.0	-0.5	0.9	1.0
Reaction time premature initiation rate	5.0	6.6	8.9	3.0	-2.6	-2.0
Reaction time premature initiations	3.6	5.1	6.1	2.5	-2.3	-2.0
Std. dev. reaction times	0.2	0.2	0.3	-0.5	0.3	0.5
Reaction time trials completed	0.2	0.3	0.7	0.2	-0.5	-0.8
Reaction time trials AUC	0.2	0.3	0.7	0.1	-0.4	-0.8
Run reversals in cocaine runway, females	0.1	0.1	0.3	0.1	-0.2	0.5
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.1	-0.1	0.1
Latency to leave start box in cocaine runway	0.2	0.2	0.3	-0.0	0.4	0.6
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.1	0.3	0.5
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.1	0.2	0.2
Std. dev. time between licks in bursts	0.6	0.7	0.8	0.8	-0.9	-0.9
Total sessions with >9 infusions	0.1	0.1	0.2	0.5	-0.1	-0.3
Short access day 1 total inactive lever presses	0.9	1.0	1.5	-1.2	1.2	0.5
Short access day 10 total inactive lever presses	1.2	1.3	1.9	1.4	-1.1	-1.0
Short access day 1 total infusions	0.0	0.0	0.1	0.2	0.3	-0.2
Short access day 10 total infusions	0.1	0.1	0.2	0.2	-0.3	-0.4
Short access total infusions	0.1	0.1	0.2	0.2	0.0	-0.5
Short access day 1 locomotion	2.8	3.0	3.5	1.4	-1.9	-1.9
Short access day 10 total locomotion	2.2	2.5	3.5	1.4	-1.9	-1.4
Short access total locomotion	6.0	6.3	6.8	2.4	-2.6	-2.5
One hour access (0.3 mA shock)	0.7	0.8	1.0	-1.0	0.8	0.9
Compulsive drug intake	4.7	4.8	6.6	2.6	-1.9	-2.0
One hour access (shock baseline)	4.9	5.7	6.9	-2.6	2.3	2.2
Social response proportion	0.4	0.4	0.7	-0.8	0.5	0.5
Social responses	0.5	0.7	1.2	-1.1	0.6	0.6
Social time	0.1	0.1	0.3	-0.0	-0.5	-0.4
Soleus weight	0.3	1.0	1.7	-1.3	1.1	-0.3
Bone: stiffness	0.1	0.1	0.2	0.5	-0.4	0.2
Tibialis anterior weight	1.5	5.2	6.2	-2.5	2.5	1.7
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.4	-0.6	0.5	0.3
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.1	0.0	0.1
Time to tail flick, test, before self-admin	1.0	0.9	1.2	1.1	-0.7	-1.1
Time to tail flick, test, after self-admin	0.6	0.6	1.0	-0.9	1.0	0.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.4	-0.2	0.0
Delta time to tail flick, test, before/after SA	0.8	0.7	1.0	-1.0	0.9	0.6
Tibia length	0.3	0.8	1.5	0.7	-0.7	-1.2
Ambulatory time before self-admin	0.0	0.1	0.1	-0.2	-0.2	-0.3
Ambulatory time after self-admin	0.1	0.1	0.2	-0.5	0.1	0.4
Bone: tissue strength	0.6	0.6	1.4	0.1	-0.6	-1.2
Total heroin consumption	0.1	0.2	0.4	0.1	-0.6	-0.3
Bone: trabecular number	0.4	0.6	1.0	0.7	-0.5	-1.0
Bone: trabecular spacing	1.1	1.5	1.9	-1.4	1.1	1.2
Bone: trabecular thickness	2.3	2.7	3.7	1.5	-1.5	-1.9
Bone: trabecular tissue density	0.0	0.0	0.1	-0.1	-0.2	0.2
Water consumed over 24 hours	0.0	0.1	0.1	-0.3	-0.2	-0.2
Number of responses in last shaping day	0.2	0.2	0.5	0.4	-0.7	0.1