Hub : Genes

Osbpl9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Osbpl9	0.06	0.04	2.8e-05	0.01	0.02	0.03	0.02	1.9e-02	3.6e-04	1.0e-04	3.5e-04
2	Liver	gene expression	Osbpl9	0.45	0.18	0.0e+00	0.19	0.22	0.22	0.22	7.8e-21	2.7e-24	1.7e-24	2.1e-24
3	Brain	gene expression	Osbpl9	0.14	0.09	1.4e-08	0.07	0.1	0.09	0.09	2.6e-07	2.5e-09	2.1e-08	8.4e-09
4	Liver	intron excision ratio	chr5_129087292_129119547	0.06	0.04	4.2e-04	0.01	0.02	0.02	0.02	2.8e-02	9.6e-04	1.3e-03	4.5e-03
5	Liver	alternative TSS	XM_039109564.2	0.07	0.05	9.6e-05	0	0.02	0.01	0.01	3.0e-01	2.9e-03	9.9e-03	4.0e-02
6	IC	gene expression	Osbpl9	0.22	0.14	4.3e-04	0.09	0.09	0.08	0.09	1.7e-04	1.0e-04	2.6e-04	1.5e-04
7	pVTA	intron excision ratio	chr5_129119623_129120517	0.03	0.03	4.8e-03	0.03	0.02	0.03	0.03	8.4e-04	1.4e-02	1.5e-03	1.9e-03
8	Liver	alternative TSS	XM_039109559.2	0.04	0.03	2.8e-03	0	0	0.01	0.01	3.3e-01	2.1e-01	3.1e-02	6.2e-02
9	PL	intron excision ratio	chr5_129119623_129147542	0.03	0.02	3.7e-03	0	0.01	0.01	0.01	2.2e-01	4.7e-02	2.5e-02	3.2e-02
10	pVTA	gene expression	Osbpl9	0.07	0.09	2.1e-04	0.05	0.05	0.05	0.05	8.5e-05	8.7e-05	7.3e-05	5.3e-05
11	Liver	alternative TSS	XM_039109564.2	0.04	0.03	6.4e-04	0.01	0.01	0.01	0.01	9.3e-03	1.1e-02	1.9e-02	1.8e-02
12	Liver	intron excision ratio	chr5_129087292_129103184	0.04	0.03	2.1e-03	0.01	0.01	0.01	0.01	1.2e-02	4.7e-02	6.0e-02	3.3e-02
13	Liver	mRNA stability	Osbpl9	0.04	0.03	1.8e-03	0.02	0.01	0.01	0.01	5.4e-03	2.1e-02	1.6e-02	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bone: apparent density	0.4	0.8	2.0	0.6	0.8	-0.6	-0.3	0.3	0.1	-1.0	1.1	1.2	-1.4	-1.0	-1.0	1.0
Area under the delay curve	0.2	0.2	0.7	0.8	0.5	-0.7	-0.8	0.8	-0.8	0.0	0.1	-0.2	-0.2	-0.1	-0.1	0.1
BMI with tail	1.4	5.0	6.7	-2.4	-2.6	2.3	1.9	-2.0	1.0	2.6	-2.5	-2.0	2.1	2.5	2.3	-2.3
BMI without tail	0.4	2.1	2.8	-1.4	-1.5	1.4	1.0	-1.1	0.4	1.7	-1.7	-1.5	1.5	1.7	1.6	-1.6
Body weight	0.7	3.2	4.2	-1.8	-2.1	1.9	1.5	-1.6	0.8	2.1	-2.0	-1.7	2.0	2.0	1.7	-1.7
Weight adjusted by age	0.3	0.7	1.4	-1.1	-1.0	1.2	1.2	-1.2	1.0	0.6	-0.7	-0.4	0.6	0.6	0.7	-0.7
Bone surface	0.2	0.5	0.8	0.7	0.7	-0.7	-0.6	0.6	-0.4	-0.7	0.8	0.7	-0.9	-0.7	-0.6	0.6
Bone volume	0.0	0.1	0.3	0.1	0.2	-0.2	-0.1	0.1	-0.0	-0.2	0.3	0.3	-0.6	-0.2	-0.1	0.1
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.1	-0.0	0.1	0.2	-0.1	0.2	-0.1	0.1	0.3	-0.2	-0.1	-0.1	0.1
Number of licking bursts	0.1	0.4	0.7	-0.8	-0.8	0.8	0.8	-0.8	0.7	0.5	-0.5	-0.1	0.2	0.5	0.3	-0.3
Context. condit. distance diff. score	0.2	0.2	0.7	0.1	0.3	-0.0	0.2	-0.2	0.5	-0.7	0.4	0.3	-0.4	-0.5	-0.8	0.8
Locomotion velocity, session 1	1.9	2.1	4.5	0.6	1.2	-0.6	0.0	0.1	0.9	-1.8	1.8	2.1	-1.8	-1.8	-2.0	2.0
Locomotion distance, session 1	0.1	0.1	0.3	-0.3	-0.1	0.3	0.4	-0.4	0.6	-0.1	0.1	0.3	0.0	-0.1	-0.4	0.4
Locomotion velocity, session 2	1.8	2.1	4.2	0.5	1.1	-0.5	0.1	-0.0	1.0	-1.8	1.7	2.0	-1.9	-1.7	-2.0	2.0
Locomotion distance, session 2	0.3	0.4	1.0	0.1	-0.2	-0.1	-0.5	0.4	-0.9	0.8	-0.7	-1.0	0.6	0.7	0.5	-0.5
Locomotion velocity, session 3	0.6	0.7	1.2	0.6	0.9	-0.6	-0.4	0.4	0.0	-1.0	1.0	1.1	-1.0	-1.0	-1.1	1.1
Locomotion distance, session 3	0.2	0.2	0.8	0.4	0.3	-0.5	-0.7	0.7	-0.9	0.1	-0.1	-0.6	0.4	0.1	0.1	-0.1
Stereotopy head waving bouts, day 3	0.1	0.1	0.4	-0.5	-0.3	0.3	0.4	-0.4	0.6	0.0	0.3	0.7	-0.3	-0.3	0.1	-0.1
Stereotopy head waving duration, day 3	0.5	0.7	2.1	-0.8	-0.3	0.6	1.0	-1.0	1.4	-0.3	0.6	1.3	-0.7	-0.6	-0.4	0.4
Locomotion velocity, session 7	0.7	0.8	1.6	1.1	0.9	-1.1	-1.3	1.3	-1.3	-0.5	0.2	-0.9	-0.6	-0.4	-0.7	0.7
Locomotion distance, session 7	1.5	1.9	5.6	1.8	1.3	-1.8	-2.1	2.1	-2.4	-0.4	0.1	-1.4	-0.2	-0.3	-0.4	0.4
Stereotopy head waving bouts, day 7	1.1	1.3	2.9	0.3	0.8	-0.5	-0.1	0.2	0.6	-1.3	1.6	1.7	-1.6	-1.6	-1.2	1.2
Stereotopy head waving duration, day 7	1.1	1.3	3.5	0.2	0.8	-0.4	0.1	-0.0	0.8	-1.3	1.6	1.9	-1.5	-1.5	-1.3	1.3
Locomotion velocity, session 8	1.5	1.8	3.6	1.1	1.3	-1.1	-0.7	0.7	-0.0	-1.7	1.5	1.0	-1.7	-1.6	-1.9	1.9
Locomotion distance, session 8	0.1	0.1	0.4	0.3	0.3	-0.3	-0.3	0.3	-0.2	-0.2	0.0	-0.4	-0.1	-0.1	-0.6	0.6
Degree of sensitization distance	0.2	0.2	0.9	0.4	0.2	-0.3	-0.6	0.5	-0.8	0.1	-0.4	-0.9	0.1	0.3	0.1	-0.1
Degree of sensitization stereotypy	0.5	0.6	1.3	0.3	0.6	-0.4	-0.1	0.2	0.3	-0.9	1.0	1.2	-1.0	-1.0	-0.9	0.9
Conditioned locomotion	0.6	0.6	1.6	-1.1	-0.9	1.1	1.2	-1.2	1.3	0.4	-0.5	-0.1	0.1	0.4	0.3	-0.3
Cocaine response after cond. corrected	0.8	1.2	2.3	-0.3	-0.7	0.2	-0.3	0.2	-1.1	1.5	-1.3	-1.4	1.5	1.4	1.3	-1.3
Cocaine response after cond. not corrected	1.1	1.6	3.1	-0.7	-1.1	0.7	0.1	-0.2	-0.6	1.8	-1.5	-1.5	1.6	1.6	1.6	-1.6
Cocaine response before conditioning	0.2	0.3	0.6	-0.7	-0.6	0.7	0.8	-0.7	0.8	0.3	-0.3	-0.0	0.1	0.2	0.5	-0.5
Saline control response	0.9	1.3	4.0	1.4	0.9	-1.4	-1.7	1.7	-2.0	-0.1	0.0	-1.3	-0.2	-0.2	-0.3	0.3
Bone: connectivity density	1.1	1.8	2.8	1.3	1.4	-1.3	-1.0	1.1	-0.5	-1.4	1.5	1.5	-1.7	-1.4	-1.5	1.5
Bone: cortical apparent density	1.0	1.6	4.4	0.6	1.1	-0.6	-0.1	0.2	0.6	-1.6	1.6	1.7	-2.1	-1.6	-1.3	1.3
Bone: cortical area	0.7	1.2	3.2	-0.6	-1.1	0.6	0.2	-0.3	-0.4	1.4	-1.5	-1.8	1.4	1.4	1.1	-1.1
Bone: cortical porosity	1.0	1.1	3.8	-1.3	-0.9	1.3	1.7	-1.6	1.9	0.0	-0.0	0.9	-0.3	0.0	0.1	-0.1
Bone: cortical porosity	0.7	0.8	2.9	-0.8	-0.5	0.9	1.3	-1.2	1.7	-0.4	0.3	1.0	-0.7	-0.4	-0.4	0.4
Bone: cortical thickness	2.2	3.6	5.9	-1.7	-2.1	1.6	1.1	-1.2	0.3	2.2	-2.3	-2.4	2.2	2.2	2.1	-2.1
Bone: cortical thickness	2.2	2.7	3.8	-1.7	-1.9	1.6	1.4	-1.4	0.9	1.7	-1.8	-1.6	1.6	1.7	1.9	-1.9
Bone: cortical tissue density	1.1	1.7	4.8	0.6	1.1	-0.6	-0.0	0.1	0.7	-1.7	1.6	1.8	-2.2	-1.7	-1.4	1.4
Condit. Reinf. active minus inactive responses	0.3	0.4	0.8	-0.6	-0.7	0.4	0.2	-0.3	-0.0	0.8	-0.6	-0.6	0.6	0.6	0.9	-0.9
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.2	-0.6	-0.8	0.6	0.4	-0.4	0.0	0.9	-0.9	-0.9	1.1	0.9	1.1	-1.1
Condit. Reinf. active responses	0.7	0.9	1.5	-0.8	-1.0	0.7	0.4	-0.5	-0.0	1.2	-1.1	-1.0	1.0	1.1	1.2	-1.2
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.2	0.0	-0.0	-0.2	0.2	-0.4	0.2	-0.4	-0.6	0.3	0.5	0.1	-0.1
Incentive salience index mean	1.2	1.5	2.5	-1.1	-1.3	1.0	0.7	-0.8	0.1	1.6	-1.4	-1.2	1.4	1.4	1.6	-1.6
Condit. Reinf. lever presses	1.2	1.8	2.8	-1.2	-1.4	1.2	0.8	-0.8	0.1	1.7	-1.6	-1.3	1.6	1.7	1.5	-1.5
Condit. Reinf. active minus inactive responses	0.4	0.7	2.7	0.6	0.2	-0.6	-1.0	0.9	-1.3	0.4	-0.6	-1.6	0.1	0.5	0.6	-0.6
Condit. Reinf. active-inactive response ratio	0.2	0.3	1.1	0.7	0.4	-0.6	-0.9	0.8	-1.0	0.0	-0.2	-1.0	-0.2	0.1	0.1	-0.1
Condit. Reinf. active responses	0.2	0.3	1.5	0.1	-0.2	-0.1	-0.3	0.3	-0.6	0.5	-0.7	-1.2	0.2	0.5	0.7	-0.7
Condit. Reinf. inactive responses	0.3	0.5	0.8	-0.7	-0.7	0.7	0.6	-0.6	0.4	0.7	-0.7	-0.5	0.4	0.7	0.9	-0.9
Condit. Reinf. lever presses	0.9	1.2	2.9	1.5	1.3	-1.5	-1.7	1.6	-1.7	-0.6	0.6	-0.0	-0.7	-0.5	-0.5	0.5
Condit. Reinf. lever reinforcers received	0.2	0.3	1.3	0.4	0.1	-0.3	-0.6	0.6	-0.9	0.3	-0.5	-1.1	0.1	0.5	0.5	-0.5
Conditioned reinforcement - actives	0.5	2.0	5.1	-0.1	-0.7	0.0	-0.6	0.5	-1.5	1.7	-1.7	-2.2	1.7	1.7	1.8	-1.8
Conditioned reinforcement - inactives	0.0	0.1	0.1	-0.3	-0.3	0.2	0.2	-0.2	0.0	0.3	-0.3	-0.3	0.3	0.3	0.2	-0.2
Conditioned locomotion	0.5	0.7	1.7	-0.2	-0.5	0.2	-0.2	0.1	-0.7	1.0	-1.0	-1.3	1.1	1.0	1.0	-1.0
Patch foraging indifference point 0 sec	0.1	0.3	0.6	-0.4	-0.6	0.4	0.2	-0.2	-0.2	0.7	-0.7	-0.8	0.5	0.7	0.7	-0.7
Patch foraging indifference point AUC	0.1	0.2	0.4	0.4	0.5	-0.4	-0.3	0.3	-0.1	-0.6	0.6	0.6	-0.5	-0.6	-0.6	0.6
Delay disc. indifference point, 0s delay	0.8	0.9	1.7	1.3	1.0	-1.2	-1.3	1.3	-1.2	-0.3	0.6	0.1	-0.6	-0.6	-0.8	0.8
Delay disc. indifference point, 16s delay	0.5	0.8	1.7	-0.4	-0.8	0.5	0.2	-0.3	-0.3	1.3	-1.1	-1.1	1.0	1.1	1.1	-1.1
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.5	0.4	-0.4	-0.4	0.4	-0.4	-0.1	0.2	-0.1	-0.3	-0.2	-0.3	0.3
Delay disc. indifference point, 24s delay	0.1	0.2	0.4	0.6	0.6	-0.6	-0.5	0.6	-0.4	-0.3	0.3	-0.1	-0.5	-0.4	-0.2	0.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.2	0.1	-0.2	-0.3	0.3	-0.4	0.1	-0.2	-0.3	-0.0	0.2	0.4	-0.4
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	0.6	0.3	-0.5	-0.6	0.6	-0.6	0.2	0.0	-0.3	-0.1	-0.0	-0.1	0.1
Indifference point function ln k	0.1	0.4	0.7	-0.5	-0.7	0.6	0.4	-0.4	0.0	0.8	-0.9	-0.8	0.6	0.8	0.7	-0.7
Indifference point function log k	0.1	0.4	0.7	-0.5	-0.7	0.6	0.4	-0.4	0.0	0.8	-0.9	-0.8	0.6	0.8	0.7	-0.7
Patch foraging total patch changes 0 sec	0.1	0.3	0.5	-0.5	-0.6	0.4	0.3	-0.3	-0.0	0.7	-0.6	-0.7	0.4	0.6	0.7	-0.7
Patch foraging total patch changes 12 sec	0.7	1.0	1.6	0.8	1.1	-0.9	-0.6	0.7	-0.1	-1.2	1.3	1.0	-1.2	-1.3	-1.1	1.1
Patch foraging total patch changes 18 sec	0.1	0.2	0.3	-0.4	-0.4	0.3	0.2	-0.2	-0.0	0.5	-0.5	-0.5	0.5	0.6	0.6	-0.6
Patch foraging total patch changes 24 sec	0.3	1.0	1.4	-1.1	-1.2	1.0	0.8	-0.9	0.4	1.1	-1.1	-1.0	1.0	1.1	1.1	-1.1
Patch foraging total patch changes 6 sec	0.1	0.2	0.8	0.4	0.2	-0.5	-0.7	0.6	-0.9	0.2	-0.1	-0.6	0.1	0.1	0.2	-0.2
Patch foraging time to switch 0 sec	0.3	1.2	2.5	0.6	1.0	-0.6	-0.2	0.3	0.4	-1.3	1.4	1.6	-1.3	-1.4	-1.4	1.4
Patch foraging water rate 0 sec	0.7	2.5	3.5	-1.5	-1.7	1.5	1.1	-1.2	0.4	1.8	-1.9	-1.7	1.5	1.8	1.9	-1.9
Patch foraging water rate 12 sec	0.6	2.5	4.1	-1.2	-1.6	1.2	0.6	-0.7	-0.2	2.0	-1.9	-2.0	2.0	1.9	1.8	-1.8
Patch foraging water rate 18 sec	0.1	0.1	0.4	-0.4	-0.3	0.4	0.5	-0.5	0.6	0.0	-0.1	0.0	-0.3	0.0	0.3	-0.3
Patch foraging water rate 24 sec	0.1	0.2	0.4	-0.6	-0.5	0.6	0.7	-0.7	0.7	0.1	-0.2	0.0	-0.1	0.2	0.1	-0.1
Patch foraging water rate 6 sec	1.0	1.5	2.3	-1.1	-1.3	1.1	0.8	-0.9	0.3	1.5	-1.5	-1.4	1.0	1.5	1.4	-1.4
Seeking ratio, delayed vs. immediate footshock	1.4	2.0	3.9	-1.0	-1.4	1.0	0.5	-0.6	-0.3	1.8	-1.9	-2.0	1.8	1.8	1.4	-1.4
Distance traveled before self-admin	0.2	0.3	0.7	-0.7	-0.6	0.8	0.8	-0.8	0.7	0.4	-0.4	0.2	0.4	0.5	0.4	-0.4
Distance traveled after self-admin	0.6	1.0	1.4	-1.0	-1.2	1.1	0.9	-1.0	0.5	1.1	-1.1	-0.7	0.9	1.2	1.1	-1.1
Extensor digitorum longus weight	1.3	5.3	8.2	-2.5	-2.6	2.4	2.1	-2.1	1.3	2.4	-2.4	-1.8	1.9	2.3	2.9	-2.9
Bone: elastic displacement	0.5	0.7	1.7	-1.1	-0.8	1.1	1.2	-1.2	1.3	0.3	-0.3	0.5	0.4	0.3	0.4	-0.4
Bone: elastic work	0.2	0.2	0.3	-0.6	-0.5	0.5	0.5	-0.5	0.4	0.4	-0.4	-0.3	0.5	0.4	0.4	-0.4
Bone: endosteal estimation	0.1	0.3	0.8	0.5	0.5	-0.4	-0.4	0.4	-0.3	-0.4	0.6	0.9	-0.3	-0.4	-0.6	0.6
Bone: endosteal perimeter	0.4	1.1	1.8	1.3	1.2	-1.2	-1.3	1.3	-1.2	-0.8	1.0	0.8	-0.7	-0.8	-0.9	0.9
Epididymis fat weight	0.1	0.5	1.0	1.0	0.9	-0.9	-1.0	1.0	-0.9	-0.4	0.4	0.1	-0.3	-0.4	-0.6	0.6
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.2	0.1	-0.2	-0.2	0.2	-0.3	0.0	-0.0	-0.2	-0.1	-0.0	-0.0	0.0
Delta time in open arm before/after self-admin	0.0	0.1	0.2	-0.1	-0.1	0.1	-0.0	0.0	-0.2	0.3	-0.2	-0.0	0.2	0.3	0.4	-0.4
Diff in mean of infusions in LGA sessions	0.2	0.3	1.0	0.7	0.4	-0.7	-0.9	0.8	-1.0	0.0	-0.2	-0.8	0.0	0.1	0.1	-0.1
Delay discount exponential model param	0.2	0.2	0.7	-0.7	-0.5	0.7	0.8	-0.8	0.8	-0.0	-0.1	0.3	0.2	0.1	0.0	-0.0
Extinction: sum of active levers before priming	0.6	0.9	2.2	-1.4	-1.0	1.3	1.5	-1.4	1.5	0.4	-0.3	0.5	0.3	0.3	0.3	-0.3
Active lever presses in extinction session 6	1.1	1.1	2.3	-0.2	-0.7	0.3	-0.2	0.1	-0.9	1.2	-1.3	-1.5	1.3	1.4	1.4	-1.4
Bone: final force	0.1	0.2	0.3	0.6	0.4	-0.5	-0.6	0.6	-0.6	-0.2	0.2	0.0	0.1	-0.2	-0.3	0.3
Bone: final moment	0.1	0.1	0.4	0.5	0.3	-0.4	-0.6	0.5	-0.7	-0.0	0.1	-0.2	0.3	-0.0	-0.1	0.1
Food consumed during 24 hour testing period	0.7	1.4	5.0	1.2	0.7	-1.2	-1.7	1.6	-2.2	0.3	-0.5	-1.5	0.5	0.5	0.6	-0.6
Glucose	0.1	0.2	0.6	0.3	0.0	-0.3	-0.5	0.5	-0.8	0.3	-0.3	-0.7	0.4	0.4	0.4	-0.4
Heart weight	1.9	3.1	4.5	-2.1	-2.0	2.1	1.9	-2.0	1.5	1.6	-1.7	-1.1	1.4	1.6	1.7	-1.7
Delay discount hyperbolic model param	0.2	0.2	0.5	-0.7	-0.5	0.6	0.7	-0.7	0.7	0.0	-0.1	0.2	0.3	0.1	0.1	-0.1
Intermittent access intake day 1-15 change	0.1	0.4	1.1	-0.1	-0.4	0.1	-0.2	0.2	-0.7	0.9	-0.8	-1.0	0.8	0.8	0.7	-0.7
Intermittent access intake escalation	0.1	0.4	0.9	-0.4	-0.6	0.4	0.1	-0.2	-0.3	0.9	-0.8	-1.0	0.8	0.8	0.7	-0.7
Intermittent access intake escalation 2	0.0	0.1	0.2	-0.2	-0.3	0.1	-0.0	0.0	-0.2	0.4	-0.4	-0.5	0.3	0.4	0.3	-0.3
Intermitt. access day 1 inactive lever presses	0.1	1.5	2.7	-0.7	-1.1	0.7	0.3	-0.4	-0.3	1.4	-1.5	-1.6	1.5	1.5	1.6	-1.6
Intermitt. access day 15 inactive lever presses	0.2	1.0	1.4	-1.1	-1.2	1.1	1.0	-1.0	0.6	1.0	-1.1	-0.9	0.8	1.0	1.0	-1.0
Intermitt. access escalation Index	0.1	0.2	0.7	-0.4	-0.3	0.5	0.7	-0.7	0.8	-0.1	-0.0	0.3	0.0	-0.0	0.0	-0.0
Intermittent access day 1 total infusions	0.1	0.2	0.6	-0.6	-0.3	0.5	0.6	-0.6	0.8	-0.1	0.1	0.4	-0.2	-0.1	-0.0	0.0
Intermittent access day 15 total infusions	0.2	0.5	0.8	-0.9	-0.8	0.8	0.7	-0.7	0.5	0.7	-0.6	-0.5	0.6	0.6	0.7	-0.7
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	-0.5	-0.4	0.4	0.4	-0.4	0.3	0.2	-0.2	-0.1	0.2	0.2	0.3	-0.3
Intermittent access total infusions	0.1	0.2	0.4	-0.6	-0.4	0.5	0.6	-0.6	0.7	0.1	0.0	0.2	-0.1	-0.0	0.1	-0.1
Intermittent access day 1 locomotion	0.0	0.1	0.3	-0.4	-0.3	0.4	0.5	-0.4	0.5	0.0	-0.0	0.2	-0.0	-0.0	0.1	-0.1
Intermittent access day 15 total locomotion	0.0	0.2	0.4	0.1	-0.1	-0.2	-0.4	0.4	-0.7	0.4	-0.4	-0.6	0.5	0.4	0.5	-0.5
Intermittent access total locomotion	0.1	0.2	0.4	-0.7	-0.5	0.6	0.6	-0.6	0.6	0.2	-0.2	0.0	0.1	0.1	0.2	-0.2
Intermittent access standard deviation	0.4	2.1	3.5	-1.1	-1.4	1.0	0.6	-0.6	-0.2	1.8	-1.8	-1.9	1.8	1.7	1.7	-1.7
Left kidney weight	2.3	18.6	28.0	-3.5	-4.5	3.5	2.2	-2.5	0.1	5.2	-5.2	-5.2	5.3	5.1	5.0	-5.0
Right kidney weight	1.6	11.4	16.9	-3.0	-3.7	3.0	2.1	-2.3	0.6	4.1	-4.0	-3.8	4.1	3.9	3.7	-3.7
Cocaine induced anxiety	0.6	1.6	3.4	-1.8	-1.5	1.6	1.6	-1.7	1.4	0.8	-1.0	-0.6	0.8	0.8	0.9	-0.9
Post-drug Anxiety	2.4	2.7	5.3	-2.3	-1.9	2.2	2.2	-2.2	1.9	1.0	-1.2	-0.7	1.0	1.0	1.2	-1.2
Baseline Anxiety	0.1	0.1	0.3	-0.1	-0.3	0.3	0.2	-0.2	0.0	0.4	-0.4	-0.4	0.4	0.4	0.5	-0.5
Tail length	0.0	0.0	0.1	0.0	0.0	0.0	0.1	-0.1	0.1	-0.2	0.1	0.2	0.1	-0.1	-0.3	0.3
Length with tail	0.1	0.3	1.0	-0.3	-0.6	0.4	0.1	-0.2	-0.3	0.7	-0.7	-0.9	1.0	0.7	0.5	-0.5
Length without tail	0.5	2.6	5.9	-0.8	-1.5	0.9	0.2	-0.4	-0.7	2.1	-2.1	-2.4	2.1	2.0	1.7	-1.7
Times rat made contact with spout	0.6	0.7	3.0	0.8	0.4	-0.8	-1.3	1.2	-1.7	0.5	-0.3	-0.8	0.4	0.4	0.5	-0.5
Lifetime Intake	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1	-0.1	0.1	-0.0	0.1	0.1	-0.1	-0.1	0.0	-0.0
Liver weight, left	0.2	0.4	0.8	0.9	0.8	-0.8	-0.9	0.9	-0.9	-0.5	0.4	-0.0	-0.1	-0.4	-0.2	0.2
Liver weight, right	0.3	0.6	1.0	1.0	0.8	-0.9	-1.0	1.0	-0.9	-0.6	0.5	0.1	-0.2	-0.5	-0.7	0.7
Locomotor activity	0.6	0.9	3.1	1.2	0.8	-1.2	-1.5	1.5	-1.8	-0.2	0.1	-0.6	-0.1	-0.0	-0.0	0.0
Locomotor testing distance	0.3	0.9	3.4	1.0	0.5	-1.0	-1.4	1.3	-1.8	0.2	-0.4	-1.0	0.4	0.4	0.2	-0.2
Locomotor testing rearing	0.4	1.5	5.5	1.5	0.9	-1.5	-1.9	1.9	-2.3	0.2	-0.1	-1.1	0.1	0.2	-0.0	0.0
Locomotion in novel chamber	1.7	2.3	4.1	-0.5	-1.1	0.5	-0.2	0.1	-1.2	2.0	-1.9	-2.0	2.0	2.0	1.9	-1.9
Locomotion in novel chamber post-restriction	0.4	1.1	2.4	-1.5	-1.2	1.4	1.5	-1.5	1.5	0.6	-0.5	0.4	0.7	0.6	0.4	-0.4
Fecal boli incidents, locomotor time 1	0.1	0.4	1.1	0.7	0.4	-0.7	-0.9	0.9	-1.1	0.2	-0.1	-0.8	0.1	0.1	-0.1	0.1
Change in fecal boli incidents, locomotor task	0.4	0.4	0.7	0.7	0.6	-0.6	-0.5	0.5	-0.3	-0.7	0.6	0.5	-0.7	-0.6	-0.9	0.9
Time >=10cm from walls, locomotor time 1	0.9	1.1	3.1	-0.2	0.3	0.2	0.7	-0.6	1.2	-1.1	1.2	1.8	-1.3	-1.1	-1.2	1.2
Bouts of movement, locomotor time 1	0.8	1.0	1.5	1.0	1.2	-1.1	-0.9	1.0	-0.6	-1.2	1.1	1.2	-0.7	-1.0	-0.8	0.8
Total resting periods, locomotor time 1	0.5	0.6	1.4	0.7	0.9	-0.7	-0.6	0.6	-0.3	-1.1	0.9	1.2	-0.6	-0.8	-0.6	0.6
Rest time, locomotor task time 1	0.2	0.3	0.6	0.7	0.6	-0.8	-0.8	0.8	-0.8	-0.4	0.3	-0.0	-0.1	-0.3	-0.3	0.3
Distance moved, locomotor task time 1	0.2	0.5	1.6	-0.7	-0.5	0.8	1.0	-1.0	1.3	-0.4	0.1	0.6	-0.4	-0.1	-0.3	0.3
Vertical activity count, locomotor time 1	0.1	0.4	0.8	-0.6	-0.7	0.6	0.5	-0.5	0.3	0.5	-0.9	-0.7	0.5	0.9	0.5	-0.5
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.6	-0.5	-0.4	0.6	0.7	-0.7	0.8	0.1	-0.2	0.1	0.1	0.3	-0.2	0.2
Bouts of movement, locomotor time 2	0.1	0.4	1.7	-0.4	0.2	0.2	0.5	-0.5	0.9	-0.7	0.7	1.3	-0.5	-0.6	-0.1	0.1
Total resting periods, locomotor time 2	0.1	0.4	1.8	-0.3	0.3	0.1	0.4	-0.4	0.8	-0.7	0.8	1.3	-0.5	-0.7	-0.0	0.0
Rest time, locomotor task time 2	0.2	0.4	0.7	0.8	0.7	-0.8	-0.8	0.8	-0.7	-0.3	0.6	0.2	-0.5	-0.6	-0.1	0.1
Distance moved, locomotor task time 2	0.9	1.2	1.8	-1.2	-1.3	1.3	1.2	-1.2	0.9	0.8	-1.3	-0.7	1.3	1.3	0.7	-0.7
Vertical activity count, locomotor time 2	0.7	1.6	3.4	-0.8	-1.2	0.9	0.5	-0.6	-0.1	1.2	-1.9	-1.7	1.8	1.8	1.3	-1.3
Light reinforcement 1	0.1	0.5	1.0	-1.0	-0.9	1.0	1.0	-1.0	0.9	0.6	-0.5	-0.1	0.6	0.5	0.4	-0.4
Light reinforcement 2	0.8	1.9	2.5	-1.4	-1.6	1.5	1.2	-1.3	0.7	1.6	-1.5	-1.2	1.5	1.5	1.3	-1.3
Bone: marrow area	0.1	0.2	0.8	0.4	0.4	-0.3	-0.3	0.3	-0.2	-0.3	0.5	0.9	-0.2	-0.3	-0.5	0.5
Bone: maximum diameter	0.1	0.2	0.3	-0.5	-0.6	0.5	0.5	-0.5	0.3	0.5	-0.4	-0.2	0.5	0.5	0.3	-0.3
Bone: maximum force	0.0	0.1	0.3	0.4	0.3	-0.4	-0.5	0.4	-0.5	-0.1	0.1	-0.1	0.1	-0.1	-0.1	0.1
Bone: maximum moment	0.0	0.1	0.3	0.4	0.1	-0.3	-0.4	0.4	-0.6	0.1	-0.1	-0.3	0.3	0.1	0.1	-0.1
Mean time between licks in bursts	0.5	2.7	3.6	1.9	1.8	-1.9	-1.7	1.8	-1.3	-1.6	1.6	0.6	-1.8	-1.7	-1.6	1.6
Mean num. licks in bursts	0.2	0.5	1.8	0.6	0.3	-0.6	-1.0	0.9	-1.4	0.4	-0.3	-0.8	0.7	0.4	0.6	-0.6
Cd content in liver	0.5	0.6	0.8	0.8	0.9	-0.8	-0.6	0.7	-0.3	-0.9	0.8	0.4	-0.8	-0.9	-0.8	0.8
Co content in liver	0.1	0.1	0.3	0.5	0.4	-0.5	-0.5	0.5	-0.6	-0.2	0.2	-0.1	0.3	-0.2	0.1	-0.1
Cu content in liver	1.6	1.9	4.4	1.8	1.5	-1.8	-2.1	2.0	-2.1	-0.7	0.8	-0.2	-0.9	-0.7	-0.6	0.6
Fe content in liver	0.9	1.1	1.6	-1.3	-1.1	1.2	1.2	-1.2	1.0	0.9	-0.8	0.1	1.2	0.9	1.0	-1.0
K content in liver	2.1	2.0	4.6	1.9	1.6	-1.9	-2.1	2.1	-2.1	-0.7	0.8	-0.2	-0.6	-0.7	-0.7	0.7
Mg content in liver	1.2	1.3	4.9	1.0	0.4	-1.0	-1.6	1.5	-2.2	0.6	-0.6	-1.6	0.8	0.6	0.5	-0.5
Mn content in liver	0.2	0.2	0.4	0.3	0.4	-0.3	-0.2	0.2	0.1	-0.5	0.5	0.5	-0.6	-0.5	-0.5	0.5
Na content in liver	0.6	0.7	1.1	1.0	1.0	-1.0	-1.0	1.0	-0.7	-0.8	0.9	0.5	-0.7	-0.8	-0.7	0.7
Rb content in liver	0.3	0.3	1.0	0.7	0.6	-0.8	-0.9	0.9	-1.0	-0.2	0.2	-0.3	-0.1	-0.2	0.0	-0.0
Se content in liver	0.5	0.6	1.2	1.0	0.8	-1.0	-1.1	1.1	-1.1	-0.4	0.4	-0.3	-0.5	-0.4	-0.5	0.5
Sr content in liver	0.0	0.0	0.0	-0.1	-0.1	0.1	0.2	-0.2	0.2	0.0	0.0	0.1	-0.0	0.0	-0.0	0.0
Zn content in liver	1.8	2.1	3.7	1.9	1.6	-1.9	-1.9	1.9	-1.8	-1.1	1.0	-0.0	-1.1	-1.1	-1.2	1.2
Bone: minimum diameter	0.3	0.6	2.4	0.7	0.2	-0.6	-1.1	1.0	-1.6	0.6	-0.5	-1.0	0.6	0.6	0.3	-0.3
Time in familiar zone, hab. session 1	0.2	0.3	0.6	0.1	0.4	-0.2	0.1	-0.0	0.4	-0.7	0.6	0.6	-0.8	-0.7	-0.6	0.6
Time in novel zone, hab. session 1	0.2	0.2	0.6	0.7	0.5	-0.6	-0.7	0.7	-0.8	-0.2	0.3	0.1	-0.2	-0.2	-0.1	0.1
Total zone transitions, hab. session 1	0.2	0.2	0.8	-0.5	-0.3	0.5	0.7	-0.6	0.9	-0.1	0.3	0.8	-0.3	-0.2	-0.3	0.3
Total locomotion distance, hab. session 1	0.7	0.9	1.9	-1.3	-1.1	1.3	1.4	-1.4	1.4	0.7	-0.5	0.2	0.5	0.5	0.6	-0.6
Locomotion velocity, hab. session 1	0.4	0.6	1.3	-1.1	-0.9	1.0	1.1	-1.1	1.1	0.5	-0.3	0.3	0.5	0.4	0.4	-0.4
Time in familiar zone, hab. session 2	1.1	1.3	2.6	1.5	1.3	-1.5	-1.6	1.6	-1.5	-0.8	0.7	-0.2	-0.7	-0.8	-0.6	0.6
Time in novel zone, hab. session 2	0.4	0.5	1.1	-0.9	-0.7	0.9	1.0	-1.0	1.1	0.4	-0.2	0.5	0.3	0.3	0.3	-0.3
Total zone transitions, hab. session 2	0.2	0.2	0.6	0.5	0.4	-0.6	-0.7	0.7	-0.8	-0.0	0.1	-0.3	-0.0	-0.1	-0.3	0.3
Total locomotion distance, hab. session 2	0.1	0.2	0.4	-0.4	-0.4	0.2	0.1	-0.1	-0.1	0.6	-0.5	-0.6	0.6	0.5	0.5	-0.5
Locomotion velocity, hab. session 2	0.2	0.3	0.5	-0.4	-0.5	0.3	0.2	-0.2	-0.1	0.7	-0.6	-0.7	0.7	0.6	0.6	-0.6
Novel to familiar place preference ratio	0.6	0.8	1.5	-0.0	-0.4	0.1	-0.4	0.3	-1.1	1.1	-1.1	-1.2	1.2	1.2	1.1	-1.1
Novelty place preference	0.3	0.4	0.8	-0.0	-0.3	0.1	-0.3	0.2	-0.8	0.8	-0.8	-0.8	0.9	0.9	0.8	-0.8
Time in novel zone, NPP test	0.3	0.3	0.6	0.1	-0.2	-0.0	-0.3	0.3	-0.8	0.7	-0.6	-0.6	0.7	0.7	0.7	-0.7
Total zone transitions, NPP test	0.7	1.0	1.5	-1.1	-1.2	1.1	1.0	-1.0	0.7	1.1	-1.0	-0.7	1.0	1.0	1.0	-1.0
Total locomotion distance, NPP test	0.8	1.1	1.6	-1.2	-1.2	1.1	0.9	-0.9	0.5	1.2	-1.0	-0.7	1.2	1.0	1.3	-1.3
Locomotion velocity, NPP test	1.3	1.8	2.5	-1.4	-1.5	1.3	1.0	-1.1	0.6	1.5	-1.4	-1.1	1.5	1.4	1.6	-1.6
Intraocular pressure	0.1	0.2	0.6	-0.0	-0.2	-0.0	-0.2	0.2	-0.5	0.5	-0.5	-0.8	0.5	0.5	0.7	-0.7
Delta distance traveled before/after self-admin	0.8	0.9	1.9	-0.6	-0.9	0.5	0.2	-0.3	-0.3	1.2	-1.2	-1.4	1.1	1.2	1.3	-1.3
Delta ambulatory time before/after self-admin	0.4	0.6	1.2	-0.4	-0.7	0.4	0.1	-0.2	-0.3	1.0	-1.0	-1.1	0.9	1.0	1.0	-1.0
Parametrial fat weight	0.0	0.1	0.2	-0.2	-0.1	0.1	0.3	-0.2	0.4	-0.3	0.3	0.4	-0.2	-0.3	-0.3	0.3
Pavlov. Cond. lever latency	1.6	2.0	2.9	1.6	1.7	-1.4	-1.2	1.2	-0.7	-1.7	1.4	1.0	-1.5	-1.4	-1.6	1.6
Pavlov. Cond. magazine entry latency	0.2	0.3	0.5	0.5	0.6	-0.6	-0.5	0.5	-0.3	-0.6	0.7	0.7	-0.5	-0.6	-0.5	0.5
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1	-0.1	0.0	0.2	-0.1	-0.0	-0.0	0.1	0.1	-0.1
Pavlov. Cond. index score	0.2	0.3	0.5	-0.6	-0.6	0.5	0.4	-0.4	0.2	0.7	-0.5	-0.3	0.7	0.6	0.7	-0.7
Pavlov. Cond. latency score	0.3	0.3	0.7	-0.7	-0.7	0.5	0.4	-0.4	0.1	0.8	-0.5	-0.4	0.7	0.6	0.7	-0.7
Pavlov. Cond. lever contacts	1.2	1.5	2.1	-1.4	-1.4	1.3	1.1	-1.1	0.7	1.4	-1.1	-0.7	1.3	1.2	1.4	-1.4
Pavlov. Cond. magazine entry number	0.2	0.3	0.8	-0.3	-0.5	0.4	0.2	-0.3	0.0	0.5	-0.7	-0.9	0.4	0.6	0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.9	0.2	-0.2	-0.3	-0.7	0.6	-1.1	0.8	-0.7	-1.4	0.7	0.7	0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.4	0.8	-0.7	-0.7	0.6	0.4	-0.5	0.1	0.9	-0.6	-0.4	0.9	0.7	0.8	-0.8
Pavlov. Cond. response bias	0.1	0.2	0.3	-0.6	-0.5	0.5	0.5	-0.5	0.5	0.4	-0.2	0.2	0.4	0.3	0.4	-0.4
Pavlov. Cond. lever latency	1.2	1.7	5.6	-1.7	-1.2	1.7	2.1	-2.0	2.4	0.2	-0.2	0.7	0.3	0.1	0.2	-0.2
Pavlov. Cond. magazine entry latency	2.8	4.0	8.1	2.7	2.3	-2.6	-2.8	2.8	-2.8	-1.3	1.3	0.2	-1.1	-1.2	-1.1	1.1
Pavlov. Cond. change in total contacts	0.9	2.3	6.7	2.0	1.5	-1.9	-2.3	2.3	-2.6	-0.5	0.3	-0.8	-0.5	-0.3	-0.5	0.5
Pavlov. Cond. index score	2.4	3.8	9.5	2.6	2.2	-2.6	-3.0	2.9	-3.1	-1.0	0.9	-0.2	-0.8	-0.8	-0.9	0.9
Pavlov. Cond. latency score	2.2	3.5	8.9	2.5	2.1	-2.5	-2.8	2.8	-3.0	-0.9	0.9	-0.2	-0.8	-0.8	-0.8	0.8
Pavlov. Cond. lever contacts	0.9	1.4	4.4	1.6	1.2	-1.5	-1.9	1.8	-2.1	-0.3	0.3	-0.5	-0.4	-0.2	-0.3	0.3
Pavlov. Cond. magazine entry number	4.2	5.5	9.4	-3.0	-2.7	3.0	3.1	-3.1	2.8	1.8	-1.8	-0.7	1.7	1.7	1.9	-1.9
Pavlov. Cond. intertrial magazine entries	0.4	0.8	2.7	-1.2	-0.8	1.1	1.4	-1.4	1.6	0.1	-0.2	0.3	-0.3	0.1	0.3	-0.3
Pavlov. Cond. lever-magazine prob. diff.	2.8	4.3	10.7	2.8	2.3	-2.7	-3.1	3.1	-3.3	-1.0	1.0	-0.3	-0.8	-0.9	-0.9	0.9
Pavlov. Cond. response bias	2.0	2.7	6.3	2.2	1.8	-2.2	-2.4	2.4	-2.5	-0.9	0.8	-0.2	-0.9	-0.7	-0.9	0.9
Time in closed arm before self-admin	0.1	0.2	0.5	0.1	0.3	-0.1	0.2	-0.1	0.5	-0.6	0.6	0.5	-0.6	-0.7	-0.7	0.7
Time in closed arm after self-admin	0.1	0.1	0.3	-0.2	-0.0	0.2	0.4	-0.3	0.6	-0.4	0.3	0.2	-0.5	-0.4	-0.5	0.5
Time in open arm before self-admin	0.3	0.4	1.2	0.8	0.5	-0.8	-1.0	0.9	-1.1	-0.0	0.0	-0.3	-0.0	0.1	0.0	-0.0
Time in open arm after self-admin	0.4	0.4	0.9	-0.1	-0.4	0.1	-0.2	0.1	-0.7	0.9	-0.7	-0.5	0.8	0.9	0.9	-0.9
Bone: periosteal estimation	0.1	0.3	0.6	-0.4	-0.6	0.5	0.2	-0.3	-0.1	0.8	-0.7	-0.5	0.8	0.8	0.5	-0.5
Bone: periosteal perimeter	0.0	0.1	0.3	0.3	0.1	-0.2	-0.4	0.4	-0.6	0.2	-0.1	-0.2	0.2	0.2	0.0	-0.0
Bone: post-yield work	0.1	0.1	0.3	0.4	0.4	-0.3	-0.3	0.3	-0.3	-0.2	0.4	0.5	-0.1	-0.2	-0.4	0.4
Progressive ratio test 1 active lever presses	0.5	0.8	1.2	-1.1	-1.1	1.0	0.8	-0.8	0.5	1.0	-0.9	-0.8	0.9	0.9	0.9	-0.9
Progressive ratio test 1 breakpoint	0.5	0.8	1.3	-1.1	-1.1	1.0	0.9	-0.9	0.5	1.0	-0.9	-0.7	0.9	0.9	0.9	-0.9
Progressive ratio test 1 inactive lever presses	0.2	0.6	0.9	-0.9	-0.9	0.9	0.8	-0.8	0.5	0.7	-0.8	-0.6	0.6	0.8	0.7	-0.7
Progressive ratio test 2 active lever presses	0.4	0.6	1.0	-1.0	-0.9	0.8	0.7	-0.7	0.5	0.8	-0.8	-0.6	0.6	0.7	0.7	-0.7
Progressive ratio test 2 breakpoint	0.6	0.7	1.4	-1.2	-1.1	1.0	0.9	-1.0	0.7	0.8	-0.8	-0.6	0.6	0.7	0.8	-0.8
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	-0.3	-0.3	0.2	0.1	-0.1	-0.0	0.3	-0.3	-0.3	0.1	0.2	0.3	-0.3
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1	-0.1	0.1	0.1	-0.0	-0.0	-0.1	0.0	0.0	-0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.3	-0.2	0.1	0.1	-0.1	0.1	0.1	-0.1	-0.1	-0.0	0.1	0.1	-0.1
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.1	-1.1	-0.8	1.0	1.1	-1.1	1.0	0.4	-0.3	0.4	0.3	0.4	0.5	-0.5
Progressive ratio	0.1	0.2	0.7	-0.1	-0.4	0.2	0.0	-0.1	-0.2	0.6	-0.6	-0.6	0.8	0.6	0.4	-0.4
Food seeking constrained by brief footshock	1.9	2.3	3.9	1.2	1.5	-1.1	-0.6	0.7	0.2	-1.9	1.9	1.8	-1.6	-1.9	-2.0	2.0
Seeking ratio, punishment vs. effort	1.2	2.7	4.3	1.0	1.6	-1.1	-0.6	0.7	0.3	-2.1	2.1	2.0	-2.1	-2.1	-1.9	1.9
Retroperitoneal fat weight	0.0	0.2	0.4	0.3	0.3	-0.2	-0.1	0.1	0.2	-0.6	0.6	0.6	-0.5	-0.6	-0.7	0.7
Reaction time number correct	0.1	0.5	1.5	-0.9	-0.6	0.9	1.1	-1.1	1.2	0.1	-0.1	0.4	-0.3	0.1	0.3	-0.3
Reaction time mean minus median	0.4	2.3	6.4	2.0	1.6	-2.0	-2.4	2.3	-2.5	-0.4	0.5	-0.6	-0.3	-0.5	-0.2	0.2
Reaction time mean minus median AUC	0.2	1.6	4.2	1.7	1.4	-1.7	-2.0	1.9	-2.1	-0.4	0.5	-0.4	-0.5	-0.5	-0.3	0.3
Reaction time num false alarms	0.5	0.9	2.4	0.3	-0.2	-0.3	-0.8	0.7	-1.4	0.8	-1.1	-1.5	1.3	1.1	1.0	-1.0
Reaction time num false alarms AUC	0.7	1.6	4.3	0.1	-0.5	-0.1	-0.7	0.6	-1.5	1.3	-1.5	-2.1	1.7	1.5	1.4	-1.4
Reaction time trials correct on left	0.1	0.5	1.5	-0.9	-0.6	0.9	1.1	-1.1	1.2	0.1	-0.1	0.4	-0.3	0.1	0.3	-0.3
Reaction time trials on left	0.1	0.4	1.2	-0.8	-0.5	0.8	1.0	-0.9	1.1	0.1	-0.1	0.3	-0.3	0.1	0.3	-0.3
Reaction time mean	0.8	1.8	4.0	1.8	1.5	-1.8	-2.0	2.0	-2.0	-0.6	0.7	-0.1	-0.7	-0.6	-0.8	0.8
Reaction time mean AUC	0.7	1.7	3.3	1.7	1.5	-1.7	-1.8	1.8	-1.7	-0.8	0.8	0.2	-0.9	-0.8	-0.9	0.9
Median of all reaction times	0.8	1.2	2.2	1.5	1.2	-1.4	-1.5	1.5	-1.4	-0.7	0.7	0.2	-0.8	-0.6	-0.9	0.9
Reaction time omissions	0.9	1.5	5.5	1.5	1.0	-1.5	-2.0	1.9	-2.3	0.2	-0.1	-1.2	0.1	0.1	0.1	-0.1
Reaction time false alarm rate	1.2	1.7	4.5	0.4	-0.3	-0.4	-1.1	1.0	-1.9	1.2	-1.4	-2.1	1.8	1.4	1.2	-1.2
Reaction time premature initiation rate	0.3	0.5	1.1	1.0	0.7	-1.0	-1.1	1.1	-1.0	-0.3	0.5	-0.1	-0.5	-0.6	-0.3	0.3
Reaction time premature initiations	0.1	0.2	0.4	0.5	0.5	-0.5	-0.5	0.5	-0.3	-0.4	0.5	0.2	-0.7	-0.6	-0.3	0.3
Std. dev. reaction times	0.7	2.3	6.9	2.0	1.5	-2.0	-2.4	2.3	-2.6	-0.2	0.3	-0.8	-0.2	-0.3	-0.2	0.2
Reaction time trials completed	0.1	0.4	1.2	-0.8	-0.5	0.8	1.0	-0.9	1.1	0.1	-0.1	0.3	-0.3	0.1	0.3	-0.3
Reaction time trials AUC	0.1	0.4	1.1	-0.8	-0.6	0.9	1.0	-1.0	1.0	0.2	-0.3	0.1	-0.1	0.3	0.5	-0.5
Run reversals in cocaine runway, females	0.4	0.4	0.8	0.8	0.8	-0.9	-0.9	0.9	-0.9	-0.4	0.5	0.3	-0.3	-0.4	-0.5	0.5
Run reversals in cocaine runway, males	1.2	1.3	2.4	-0.1	-0.5	0.1	-0.5	0.4	-1.2	1.4	-1.3	-1.3	1.5	1.4	1.5	-1.5
Latency to leave start box in cocaine runway	1.0	1.4	2.3	-1.5	-1.4	1.4	1.3	-1.4	1.0	1.1	-1.0	-0.3	0.9	1.1	1.2	-1.2
Latency to leave start box in cocaine runway, F	2.0	2.5	4.0	-2.0	-1.8	1.9	1.8	-1.8	1.4	1.5	-1.3	-0.5	1.2	1.4	1.5	-1.5
Latency to leave start box in cocaine runway, M	0.4	0.3	0.8	0.8	0.6	-0.8	-0.9	0.9	-0.9	-0.2	0.2	-0.2	-0.2	-0.2	-0.1	0.1
Std. dev. time between licks in bursts	1.6	2.9	4.2	1.8	1.9	-1.7	-1.4	1.5	-0.8	-1.9	1.8	1.1	-2.0	-1.9	-1.9	1.9
Total sessions with >9 infusions	0.1	0.1	0.3	0.5	0.4	-0.5	-0.5	0.5	-0.5	-0.1	0.1	-0.0	-0.1	-0.1	-0.1	0.1
Short access day 1 total inactive lever presses	0.9	1.9	2.7	-1.4	-1.5	1.3	1.0	-1.1	0.5	1.5	-1.6	-1.4	1.4	1.5	1.6	-1.6
Short access day 10 total inactive lever presses	0.0	0.2	0.4	-0.3	-0.4	0.3	0.1	-0.1	-0.1	0.5	-0.6	-0.6	0.4	0.6	0.5	-0.5
Short access day 1 total infusions	0.0	0.0	0.1	-0.2	-0.2	0.2	0.2	-0.2	0.2	0.1	-0.1	-0.0	0.1	0.1	0.1	-0.1
Short access day 10 total infusions	0.4	0.6	1.4	-1.1	-0.9	1.1	1.2	-1.2	1.1	0.4	-0.4	-0.0	0.4	0.4	0.3	-0.3
Short access total infusions	0.0	0.0	0.1	0.1	0.2	-0.2	-0.1	0.1	-0.1	-0.2	0.2	0.2	-0.2	-0.2	-0.2	0.2
Short access day 1 locomotion	0.5	0.8	1.7	-0.2	-0.6	0.2	-0.2	0.1	-0.7	1.1	-1.1	-1.3	1.2	1.1	1.1	-1.1
Short access day 10 total locomotion	0.1	0.6	1.1	-0.7	-0.8	0.7	0.5	-0.6	0.2	0.9	-0.9	-0.8	1.0	0.9	0.7	-0.7
Short access total locomotion	0.0	0.0	0.1	0.0	0.1	-0.0	0.1	-0.0	0.1	-0.2	0.2	0.3	-0.1	-0.2	-0.2	0.2
One hour access (0.3 mA shock)	0.1	0.2	0.3	0.3	0.4	-0.5	-0.4	0.4	-0.3	-0.3	0.5	0.3	-0.5	-0.4	-0.3	0.3
Compulsive drug intake	0.3	0.5	1.1	0.2	0.5	-0.2	0.2	-0.1	0.6	-0.9	0.9	1.1	-0.9	-0.9	-0.7	0.7
One hour access (shock baseline)	0.3	0.8	1.5	-0.6	-0.9	0.5	0.2	-0.2	-0.3	1.2	-1.1	-1.2	1.1	1.1	1.0	-1.0
Social response proportion	0.3	0.4	0.6	0.8	0.7	-0.7	-0.7	0.7	-0.7	-0.4	0.5	0.3	-0.6	-0.5	-0.5	0.5
Social responses	1.3	1.8	2.5	1.4	1.4	-1.4	-1.2	1.2	-0.8	-1.5	1.4	1.1	-1.6	-1.4	-1.4	1.4
Social time	0.0	0.1	0.2	0.2	0.1	-0.2	-0.3	0.3	-0.5	0.1	-0.2	-0.3	0.2	0.2	0.1	-0.1
Soleus weight	2.4	7.0	11.5	-2.3	-2.8	2.2	1.5	-1.7	0.3	3.1	-3.2	-3.1	2.6	3.1	3.4	-3.4
Bone: stiffness	0.1	0.1	0.2	0.4	0.2	-0.4	-0.4	0.4	-0.4	-0.1	0.1	-0.2	-0.2	-0.1	-0.3	0.3
Tibialis anterior weight	4.4	15.2	20.0	-4.4	-4.5	4.2	3.7	-3.9	2.6	4.0	-4.0	-2.9	3.5	3.8	4.4	-4.4
Time to tail flick, vehicle, before self-admin	1.9	2.3	3.6	-1.9	-1.8	1.7	1.5	-1.6	1.0	1.6	-1.5	-0.9	1.6	1.5	1.5	-1.5
Time to tail flick, vehicle, after self-admin	0.5	1.1	1.8	-1.3	-1.2	1.4	1.3	-1.3	1.1	0.8	-0.8	-0.2	0.8	0.8	0.8	-0.8
Time to tail flick, test, before self-admin	4.7	5.4	9.9	-3.1	-2.7	3.0	3.0	-3.0	2.6	1.8	-1.7	-0.4	1.7	1.8	1.8	-1.8
Time to tail flick, test, after self-admin	1.5	1.6	2.4	-1.4	-1.5	1.6	1.4	-1.5	1.1	1.1	-1.3	-1.0	1.0	1.2	1.0	-1.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.2	-0.2	0.3	0.3	-0.3	0.3	0.1	-0.1	0.2	0.0	0.1	0.1	-0.1
Delta time to tail flick, test, before/after SA	0.7	0.9	2.1	1.4	1.0	-1.3	-1.4	1.4	-1.4	-0.4	0.3	-0.4	-0.4	-0.4	-0.5	0.5
Tibia length	0.1	0.2	0.4	-0.3	-0.5	0.4	0.2	-0.2	0.0	0.6	-0.5	-0.4	0.6	0.5	0.1	-0.1
Ambulatory time before self-admin	0.0	0.1	0.2	-0.4	-0.3	0.5	0.5	-0.5	0.4	0.2	-0.2	0.2	0.2	0.3	0.2	-0.2
Ambulatory time after self-admin	0.4	0.6	0.9	-0.8	-0.9	0.9	0.8	-0.8	0.5	0.8	-0.8	-0.4	0.7	0.9	0.9	-0.9
Bone: tissue strength	1.2	1.3	1.9	1.4	1.3	-1.4	-1.3	1.3	-1.1	-1.0	1.1	0.6	-0.8	-1.0	-0.9	0.9
Total heroin consumption	0.3	0.3	0.6	0.5	0.6	-0.4	-0.3	0.3	-0.1	-0.7	0.6	0.7	-0.8	-0.6	-0.6	0.6
Bone: trabecular number	0.6	1.2	2.9	0.9	1.1	-0.9	-0.7	0.7	-0.2	-1.2	1.2	1.0	-1.7	-1.2	-1.3	1.3
Bone: trabecular spacing	1.2	1.8	2.9	-1.4	-1.5	1.4	1.2	-1.2	0.7	1.4	-1.5	-1.2	1.7	1.4	1.4	-1.4
Bone: trabecular thickness	0.7	1.0	1.3	1.1	1.2	-1.1	-1.0	1.1	-0.8	-0.9	1.0	0.7	-1.1	-0.9	-0.9	0.9
Bone: trabecular tissue density	0.2	0.3	1.0	-0.4	-0.1	0.4	0.7	-0.6	1.0	-0.4	0.3	0.7	-0.5	-0.4	-0.2	0.2
Water consumed over 24 hours	0.4	0.8	2.4	0.4	-0.1	-0.4	-0.9	0.8	-1.5	0.9	-0.9	-1.6	0.8	0.9	0.8	-0.8
Number of responses in last shaping day	1.5	2.0	3.6	-0.9	-1.3	0.9	0.4	-0.5	-0.3	1.7	-1.7	-1.9	1.6	1.7	1.9	-1.9